TR 386 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst TETRANITROMETHANE DATE: 09/09/94
EXPERIMENT: 05072 TEST: 01 TIME: 01:29:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55947
PATHOLOGIST: M. STEDHAM CAS: 509-14-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst TETRANITROMETHANE DATE: 09/09/94
EXPERIMENT: 05072 TEST: 01 TIME: 01:29:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55947
PATHOLOGIST: M. STEDHAM CAS: 509-14-8
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst TETRANITROMETHANE DATE: 09/09/94
EXPERIMENT: 05072 TEST: 01 TIME: 01:29:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55947
PATHOLOGIST: M. STEDHAM CAS: 509-14-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRANITROMETHANE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Squamous Cell Carcinoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,
Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma
Testes Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst TETRANITROMETHANE DATE: 09/09/94
EXPERIMENT: 05072 TEST: 01 TIME: 01:29:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55947
PATHOLOGIST: M. STEDHAM CAS: 509-14-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TETRANITROMETHANE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Squamous Cell Carcinoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/49 (2%) 0/48 (0%) | 0/50 (0%) 0/49 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.5% 5.9% 0.0% | 0.0% 0.0% 13.5% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 618 727 (T) --- | --- --- 616 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531N P=0.748 P=0.602N | P=0.016 * (e) P=0.085 |
|INCIDENTAL TUMOR | P=0.343N P=0.742N P=0.318N | P=0.047 * (e) P=0.139 |
|LOGISTIC REGRESSION | P=0.390N P=0.761 P=0.494N | P=0.032 * (e) P=0.123 |
|COCHRAN-ARMITAGE | P=0.352N | P=0.033 * |
|FISHER EXACT | P=0.747 P=0.510N | (e) P=0.121 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/46 (26%) 16/48 (33%) 10/48 (21%) | 2/43 (5%) 4/48 (8%) 3/47 (6%) |
|ADJUSTED (b) | 45.5% 58.3% 83.2% | 9.1% 10.8% 18.4% |
|TERMINAL (d) | 6/18 (33%) 7/17 (41%) 2/3 (67%) | 2/22 (9%) 3/34 (9%) 2/15 (13%) |
|FIRST INCIDENCE (DAYS) | 483 541 548 | 727 (T) 563 722 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.022 * P=0.252 P=0.031 * | P=0.280 P=0.524 P=0.324 |
|INCIDENTAL TUMOR | P=0.431 P=0.297 P=0.396 | P=0.390 P=0.512 P=0.440 |
|LOGISTIC REGRESSION | P=0.412 P=0.290 P=0.433 | P=0.484 P=0.447 P=0.399 |
|COCHRAN-ARMITAGE | P=0.277N | P=0.506 |
|FISHER EXACT | P=0.294 P=0.360N | P=0.392 P=0.543 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/46 (2%) 2/48 (4%) 1/48 (2%) | 0/43 (0%) 0/48 (0%) 0/47 (0%) |
|ADJUSTED (b) | 5.6% 10.2% 2.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/18 (6%) 1/17 (6%) 0/3 (0%) | 0/22 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 699 548 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.369 P=0.477 P=0.577 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.582 P=0.501 P=0.760 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.612 P=0.490 P=0.763N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.601N | (e) |
|FISHER EXACT | P=0.516 P=0.742N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/46 (28%) 17/48 (35%) 10/48 (21%) | 2/43 (5%) 4/48 (8%) 4/47 (9%) |
|ADJUSTED (b) | 50.1% 60.2% 83.2% | 9.1% 10.8% 24.7% |
|TERMINAL (d) | 7/18 (39%) 7/17 (41%) 2/3 (67%) | 2/22 (9%) 3/34 (9%) 3/15 (20%) |
|FIRST INCIDENCE (DAYS) | 483 541 548 | 727 (T) 563 722 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029 * P=0.253 P=0.037 * | P=0.135 P=0.524 P=0.173 |
|INCIDENTAL TUMOR | P=0.499 P=0.302 P=0.428 | P=0.212 P=0.512 P=0.252 |
|LOGISTIC REGRESSION | P=0.475 P=0.294 P=0.493 | P=0.311 P=0.447 P=0.223 |
|COCHRAN-ARMITAGE | P=0.203N | P=0.343 |
|FISHER EXACT | P=0.301 P=0.275N | P=0.392 P=0.382 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 5.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 567 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.092 (e) P=0.245 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.098 (e) P=0.259 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.070 (e) P=0.201 |
|COCHRAN-ARMITAGE | (e) | P=0.092 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.0% 0.0% 5.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 727 (T) --- 567 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.289 P=0.439N P=0.447 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.303 P=0.439N P=0.469 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.320 P=0.439N P=0.490 |
|COCHRAN-ARMITAGE | (e) | P=0.335 |
|FISHER EXACT | (e) (e) | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/48 (0%) 0/49 (0%) | 1/47 (2%) 4/48 (8%) 0/44 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.0% 11.0% 0.0% |
|TERMINAL (d) | 0/17 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 3/33 (9%) 0/14 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 727 (T) 559 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.457N P=0.264 P=0.616N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.453N P=0.271 P=0.616N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.341N P=0.204 P=0.616N |
|COCHRAN-ARMITAGE | (e) | P=0.338N |
|FISHER EXACT | (e) (e) | P=0.187 P=0.516N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/48 (4%) 1/49 (2%) | 2/47 (4%) 1/48 (2%) 0/44 (0%) |
|ADJUSTED (b) | 14.6% 8.1% 3.7% | 8.0% 3.0% 0.0% |
|TERMINAL (d) | 2/17 (12%) 1/17 (6%) 0/4 (0%) | 2/25 (8%) 1/33 (3%) 0/14 (0%) |
|FIRST INCIDENCE (DAYS) | 658 556 605 | 727 (T) 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.523N P=0.492N P=0.667N | P=0.236N P=0.403N P=0.372N |
|INCIDENTAL TUMOR | P=0.289N P=0.485N P=0.469N | P=0.236N P=0.403N P=0.372N |
|LOGISTIC REGRESSION | P=0.287N P=0.504N P=0.444N | P=0.236N P=0.403N P=0.372N |
|COCHRAN-ARMITAGE | P=0.239N | P=0.170N |
|FISHER EXACT | P=0.510N P=0.309N | P=0.492N P=0.264N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/48 (4%) 1/49 (2%) | 3/47 (6%) 5/48 (10%) 0/44 (0%) |
|ADJUSTED (b) | 14.6% 8.1% 3.7% | 12.0% 14.0% 0.0% |
|TERMINAL (d) | 2/17 (12%) 1/17 (6%) 0/4 (0%) | 3/25 (12%) 4/33 (12%) 0/14 (0%) |
|FIRST INCIDENCE (DAYS) | 658 556 605 | 727 (T) 559 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.523N P=0.492N P=0.667N | P=0.202N P=0.507 P=0.238N |
|INCIDENTAL TUMOR | P=0.289N P=0.485N P=0.469N | P=0.199N P=0.514 P=0.238N |
|LOGISTIC REGRESSION | P=0.287N P=0.504N P=0.444N | P=0.119N P=0.434 P=0.238N |
|COCHRAN-ARMITAGE | P=0.239N | P=0.115N |
|FISHER EXACT | P=0.510N P=0.309N | P=0.369 P=0.133N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 5/48 (10%) 6/50 (12%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 13.2% 21.2% 42.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/18 (11%) 2/17 (12%) 1/4 (25%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 569 633 521 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014 * P=0.347 P=0.031 * | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.193 P=0.363 P=0.225 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.168 P=0.340 P=0.244 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.225 | (e) |
|FISHER EXACT | P=0.346 P=0.254 | (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 3/48 (6%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 1/49 (2%) |
|ADJUSTED (b) | 18.3% 9.3% 21.7% | 0.0% 0.0% 2.5% |
|TERMINAL (d) | 1/18 (6%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 546 535 500 | --- --- 584 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.373 P=0.345N P=0.387 | P=0.276 (e) P=0.495 |
|INCIDENTAL TUMOR | P=0.502N P=0.406N P=0.589N | P=0.299 (e) P=0.523 |
|LOGISTIC REGRESSION | P=0.437N P=0.371N P=0.529N | P=0.243 (e) P=0.461 |
|COCHRAN-ARMITAGE | P=0.457N | P=0.281 |
|FISHER EXACT | P=0.369N P=0.487N | (e) P=0.495 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/49 (16%) 8/48 (17%) 10/50 (20%) | 0/50 (0%) 0/50 (0%) 1/49 (2%) |
|ADJUSTED (b) | 29.7% 28.5% 54.8% | 0.0% 0.0% 2.5% |
|TERMINAL (d) | 3/18 (17%) 2/17 (12%) 1/4 (25%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 546 535 500 | --- --- 584 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024 * P=0.597N P=0.038 * | P=0.276 (e) P=0.495 |
|INCIDENTAL TUMOR | P=0.314 P=0.573 P=0.337 | P=0.299 (e) P=0.523 |
|LOGISTIC REGRESSION | P=0.327 P=0.591 P=0.383 | P=0.243 (e) P=0.461 |
|COCHRAN-ARMITAGE | P=0.365 | P=0.281 |
|FISHER EXACT | P=0.590 P=0.416 | (e) P=0.495 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.0% 0.0% | 4.0% 2.9% 0.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 605 --- | 727 (T) 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.659 P=0.227 (e) | P=0.442N P=0.692N P=0.602N |
|INCIDENTAL TUMOR | P=0.504N P=0.264 (e) | P=0.442N P=0.692N P=0.602N |
|LOGISTIC REGRESSION | P=0.630N P=0.237 (e) | P=0.442N P=0.692N P=0.602N |
|COCHRAN-ARMITAGE | P=0.614N | P=0.343N |
|FISHER EXACT | P=0.247 (e) | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 4.3% 7.0% 0.0% | 4.0% 2.9% 3.8% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 708 605 --- | 727 (T) 727 (T) 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556N P=0.471 P=0.736N | P=0.582 P=0.692N P=0.705 |
|INCIDENTAL TUMOR | P=0.265N P=0.526 P=0.525N | P=0.663N P=0.692N P=0.742N |
|LOGISTIC REGRESSION | P=0.384N P=0.501 P=0.663N | P=0.651 P=0.692N P=0.755 |
|COCHRAN-ARMITAGE | P=0.335N | P=0.665 |
|FISHER EXACT | P=0.500 P=0.500N | P=0.753N P=0.753N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 4.3% 7.0% 0.0% | 4.0% 2.9% 3.8% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 708 605 --- | 727 (T) 727 (T) 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556N P=0.471 P=0.736N | P=0.582 P=0.692N P=0.705 |
|INCIDENTAL TUMOR | P=0.265N P=0.526 P=0.525N | P=0.663N P=0.692N P=0.742N |
|LOGISTIC REGRESSION | P=0.384N P=0.501 P=0.663N | P=0.651 P=0.692N P=0.755 |
|COCHRAN-ARMITAGE | P=0.335N | P=0.665 |
|FISHER EXACT | P=0.500 P=0.500N | P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 13/50 (26%) 11/50 (22%) | 0/50 (0%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 5.6% 51.8% 30.4% | 0.0% 17.6% 9.9% |
|TERMINAL (d) | 1/18 (6%) 7/17 (41%) 0/4 (0%) | 0/25 (0%) 6/34 (18%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 535 497 | --- 727 (T) 567 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.094 P=0.039 * P=0.110 |
|INCIDENTAL TUMOR | P=0.013 * P<0.001 ** P=0.024 * | P=0.146 P=0.039 * P=0.181 |
|LOGISTIC REGRESSION | P=0.015 * P<0.001 ** P=0.005 ** | P=0.218 P=0.039 * P=0.111 |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.226 |
|FISHER EXACT | P<0.001 ** P=0.002 ** | P=0.013 * P=0.121 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 26/50 (52%) 46/50 (92%) | 0/50 (0%) 19/50 (38%) 50/50 (100%) |
|ADJUSTED (b) | 0.0% 76.0% 100.0% | 0.0% 52.7% 100.0% |
|TERMINAL (d) | 0/18 (0%) 10/17 (59%) 4/4 (100%) | 0/25 (0%) 17/34 (50%) 15/15 (100%) |
|FIRST INCIDENCE (DAYS) | --- 533 497 | --- 703 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 33/50 (66%) 46/50 (92%) | 0/50 (0%) 22/50 (44%) 50/50 (100%) |
|ADJUSTED (b) | 5.6% 83.2% 100.0% | 0.0% 61.0% 100.0% |
|TERMINAL (d) | 1/18 (6%) 11/17 (65%) 4/4 (100%) | 0/25 (0%) 20/34 (59%) 15/15 (100%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 533 497 | --- 703 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 19/50 (38%) | 0/50 (0%) 1/50 (2%) 12/50 (24%) |
|ADJUSTED (b) | 0.0% 5.9% 77.1% | 0.0% 2.5% 45.8% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 1/4 (25%) | 0/25 (0%) 0/34 (0%) 4/15 (27%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 518 | --- 639 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.489 P<0.001 ** | P<0.001 ** P=0.527 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.489 P<0.001 ** | P<0.001 ** P=0.523 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.489 P<0.001 ** | P<0.001 ** P=0.478 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.500 P<0.001 ** | P=0.500 P<0.001 ** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 8/50 (16%) 12/50 (24%) 6/50 (12%) |
|ADJUSTED (b) | 4.0% 0.0% 2.6% | 28.1% 30.7% 22.5% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 6/25 (24%) 8/34 (24%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 694 --- 548 | 590 428 534 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566 P=0.525N P=0.661 | P=0.562N P=0.467 P=0.603N |
|INCIDENTAL TUMOR | P=0.639N P=0.500N P=0.672N | P=0.292N P=0.297 P=0.397N |
|LOGISTIC REGRESSION | P=0.676 P=0.501N P=0.752N | P=0.285N P=0.303 P=0.373N |
|COCHRAN-ARMITAGE | P=0.657 | P=0.294N |
|FISHER EXACT | P=0.500N P=0.753N | P=0.227 P=0.387N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 8/50 (16%) 12/50 (24%) 7/50 (14%) |
|ADJUSTED (b) | 4.0% 0.0% 18.8% | 28.1% 30.7% 28.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 6/25 (24%) 8/34 (24%) 2/15 (13%) |
|FIRST INCIDENCE (DAYS) | 694 --- 548 | 590 428 534 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166 P=0.525N P=0.262 | P=0.436 P=0.467 P=0.481 |
|INCIDENTAL TUMOR | P=0.409 P=0.500N P=0.582 | P=0.417N P=0.297 P=0.542N |
|LOGISTIC REGRESSION | P=0.318 P=0.501N P=0.465 | P=0.390N P=0.303 P=0.488N |
|COCHRAN-ARMITAGE | P=0.335 | P=0.398N |
|FISHER EXACT | P=0.500N P=0.500 | P=0.227 P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 8/50 (16%) 13/50 (26%) 7/50 (14%) |
|ADJUSTED (b) | 4.0% 0.0% 18.8% | 28.1% 33.4% 28.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 6/25 (24%) 9/34 (26%) 2/15 (13%) |
|FIRST INCIDENCE (DAYS) | 694 --- 548 | 590 428 534 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166 P=0.525N P=0.262 | P=0.434 P=0.387 P=0.481 |
|INCIDENTAL TUMOR | P=0.409 P=0.500N P=0.582 | P=0.420N P=0.231 P=0.542N |
|LOGISTIC REGRESSION | P=0.318 P=0.501N P=0.465 | P=0.379N P=0.234 P=0.488N |
|COCHRAN-ARMITAGE | P=0.335 | P=0.386N |
|FISHER EXACT | P=0.500N P=0.500 | P=0.163 P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/48 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 18.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 506 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * (e) P=0.117 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.118 (e) P=0.269 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.125 (e) P=0.278 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/49 (59%) 24/49 (49%) 18/48 (38%) | 28/50 (56%) 29/48 (60%) 25/50 (50%) |
|ADJUSTED (b) | 76.2% 74.9% 70.7% | 79.4% 66.8% 87.0% |
|TERMINAL (d) | 10/18 (56%) 10/17 (59%) 1/4 (25%) | 18/25 (72%) 19/33 (58%) 12/15 (80%) |
|FIRST INCIDENCE (DAYS) | 422 591 521 | 525 559 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.165 P=0.299N P=0.223 | P=0.206 P=0.189N P=0.246 |
|INCIDENTAL TUMOR | P=0.029N* P=0.169N P=0.022N* | P=0.387N P=0.497N P=0.542N |
|LOGISTIC REGRESSION | P=0.062N P=0.185N P=0.051N | P=0.252N P=0.522N P=0.290N |
|COCHRAN-ARMITAGE | P=0.022N* | P=0.282N |
|FISHER EXACT | P=0.209N P=0.026N* | P=0.406 P=0.344N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/49 (2%) 0/48 (0%) | 1/50 (2%) 2/48 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% | 2.9% 6.1% 0.0% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 0/4 (0%) | 0/25 (0%) 2/33 (6%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) --- | 646 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.716 P=0.489 (e) | P=0.413N P=0.580 P=0.494N |
|INCIDENTAL TUMOR | P=0.716 P=0.489 (e) | P=0.316N P=0.498 P=0.341N |
|LOGISTIC REGRESSION | P=0.716 P=0.489 (e) | P=0.334N P=0.533 P=0.503N |
|COCHRAN-ARMITAGE | P=0.719N | P=0.335N |
|FISHER EXACT | P=0.500 (e) | P=0.485 P=0.500N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/49 (59%) 25/49 (51%) 18/48 (38%) | 29/50 (58%) 31/48 (65%) 25/50 (50%) |
|ADJUSTED (b) | 76.2% 78.5% 70.7% | 80.0% 71.5% 87.0% |
|TERMINAL (d) | 10/18 (56%) 11/17 (65%) 1/4 (25%) | 18/25 (72%) 21/33 (64%) 12/15 (80%) |
|FIRST INCIDENCE (DAYS) | 422 591 521 | 525 559 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.154 P=0.356N P=0.223 | P=0.257 P=0.223N P=0.310 |
|INCIDENTAL TUMOR | P=0.033N* P=0.227N P=0.022N* | P=0.288N P=0.586N P=0.421N |
|LOGISTIC REGRESSION | P=0.064N P=0.243N P=0.051N | P=0.176N P=0.575 P=0.220N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.206N |
|FISHER EXACT | P=0.271N P=0.026N* | P=0.323 P=0.274N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.1% 9.4% 0.0% | 4.0% 0.0% 6.7% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 1/25 (4%) 0/34 (0%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 618 692 --- | 727 (T) --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.357N P=0.670 P=0.379N | P=0.558 P=0.439N P=0.644 |
|INCIDENTAL TUMOR | P=0.088N P=0.655N P=0.058N | P=0.558 P=0.439N P=0.644 |
|LOGISTIC REGRESSION | P=0.202N P=0.694N P=0.228N | P=0.558 P=0.439N P=0.644 |
|COCHRAN-ARMITAGE | P=0.172N | P=0.657 |
|FISHER EXACT | P=0.691N P=0.247N | P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% | 4.0% 5.0% 2.4% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 0/4 (0%) | 1/25 (4%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) --- | 727 (T) 563 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.716 P=0.489 (e) | P=0.610 P=0.587 P=0.708 |
|INCIDENTAL TUMOR | P=0.716 P=0.489 (e) | P=0.626 P=0.584 P=0.720 |
|LOGISTIC REGRESSION | P=0.716 P=0.489 (e) | P=0.626N P=0.505 P=0.761 |
|COCHRAN-ARMITAGE | P=0.716N | P=0.613N |
|FISHER EXACT | P=0.500 (e) | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% | 0.0% 5.0% 2.4% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 0/4 (0%) | 0/25 (0%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) --- | --- 563 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.716 P=0.489 (e) | P=0.398 P=0.289 P=0.505 |
|INCIDENTAL TUMOR | P=0.716 P=0.489 (e) | P=0.415 P=0.287 P=0.523 |
|LOGISTIC REGRESSION | P=0.716 P=0.489 (e) | P=0.409 P=0.211 P=0.456 |
|COCHRAN-ARMITAGE | P=0.716N | P=0.444 |
|FISHER EXACT | P=0.500 (e) | P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 11.8% 0.0% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 0/18 (0%) 2/17 (12%) 0/4 (0%) | 0/25 (0%) 1/34 (3%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 653 727 (T) --- | --- 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382N P=0.689N P=0.377N | P=0.789 P=0.561 (e) |
|INCIDENTAL TUMOR | P=0.315N P=0.684 P=0.264N | P=0.789 P=0.561 (e) |
|LOGISTIC REGRESSION | P=0.257N P=0.694 P=0.257N | P=0.789 P=0.561 (e) |
|COCHRAN-ARMITAGE | P=0.172N | P=0.716N |
|FISHER EXACT | P=0.691N P=0.247N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 11.0% 25.4% 0.0% | 8.0% 7.9% 8.9% |
|TERMINAL (d) | 0/18 (0%) 3/17 (18%) 0/4 (0%) | 2/25 (8%) 2/34 (6%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 618 692 --- | 727 (T) 563 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.266N P=0.482 P=0.168N | P=0.489 P=0.623 P=0.554 |
|INCIDENTAL TUMOR | P=0.072N P=0.519 P=0.020N* | P=0.501 P=0.621 P=0.564 |
|LOGISTIC REGRESSION | P=0.106N P=0.500 P=0.062N | P=0.584N P=0.548 P=0.691N |
|COCHRAN-ARMITAGE | P=0.056N | P=0.587N |
|FISHER EXACT | P=0.500 P=0.059N | P=0.500 P=0.691N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 16.6% 7.8% 28.3% | 0.0% 2.9% 6.7% |
|TERMINAL (d) | 2/18 (11%) 0/17 (0%) 1/4 (25%) | 0/25 (0%) 1/34 (3%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 401 659 506 | --- 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 P=0.361N P=0.425 | P=0.257 P=0.561 P=0.398 |
|INCIDENTAL TUMOR | P=0.601N P=0.361N P=0.610 | P=0.257 P=0.561 P=0.398 |
|LOGISTIC REGRESSION | P=0.442N P=0.338N P=0.463N | P=0.257 P=0.561 P=0.398 |
|COCHRAN-ARMITAGE | P=0.467N | P=0.386 |
|FISHER EXACT | P=0.339N P=0.500N | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 3/50 (6%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 16.6% 9.8% 28.3% | 5.2% 2.9% 6.7% |
|TERMINAL (d) | 2/18 (11%) 0/17 (0%) 1/4 (25%) | 0/25 (0%) 1/34 (3%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 401 535 506 | 520 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.417 P=0.517N P=0.425 | P=0.491N P=0.433N P=0.547N |
|INCIDENTAL TUMOR | P=0.546N P=0.537N P=0.610 | P=0.400N P=0.651N P=0.469N |
|LOGISTIC REGRESSION | P=0.401N P=0.509N P=0.463N | P=0.424N P=0.545N P=0.514N |
|COCHRAN-ARMITAGE | P=0.447N | P=0.419N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.1% 0.0% | 5.2% 0.0% 0.0% |
|TERMINAL (d) | 0/18 (0%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 535 --- | 520 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.725N P=0.509 (e) | P=0.130N P=0.210N P=0.229N |
|INCIDENTAL TUMOR | P=0.635N P=0.464 (e) | P=0.096N P=0.434N P=0.156N |
|LOGISTIC REGRESSION | P=0.725N P=0.454 (e) | P=0.162N P=0.290N P=0.265N |
|COCHRAN-ARMITAGE | P=0.716N | P=0.136N |
|FISHER EXACT | P=0.500 (e) | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 38/50 (76%) 39/50 (78%) | |
|ADJUSTED (b) | 96.8% 97.3% 100.0% | |
|TERMINAL (d) | 17/18 (94%) 16/17 (94%) 4/4 (100%) | |
|FIRST INCIDENCE (DAYS) | 483 535 500 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.216 P<0.001 ** | |
|INCIDENTAL TUMOR | P=0.009 ** P=0.143 P=0.018 * | |
|LOGISTIC REGRESSION | P=0.010 ** P=0.180 P=0.020 * | |
|COCHRAN-ARMITAGE | P=0.124 | |
|FISHER EXACT | P=0.189 P=0.133 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/49 (2%) 3/50 (6%) | 3/49 (6%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 10.7% 5.9% 15.6% | 11.3% 15.9% 23.1% |
|TERMINAL (d) | 1/17 (6%) 1/17 (6%) 0/4 (0%) | 2/25 (8%) 4/34 (12%) 3/15 (20%) |
|FIRST INCIDENCE (DAYS) | 618 727 (T) 629 | 674 563 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240 P=0.322N P=0.321 | P=0.280 P=0.408 P=0.313 |
|INCIDENTAL TUMOR | P=0.535N P=0.265N P=0.465N | P=0.441 P=0.287 P=0.420 |
|LOGISTIC REGRESSION | P=0.504 P=0.297N P=0.616 | P=0.475 P=0.301 P=0.470 |
|COCHRAN-ARMITAGE | P=0.572 | P=0.502 |
|FISHER EXACT | P=0.309N P=0.651N | P=0.254 P=0.511 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/49 (2%) 0/50 (0%) | 3/49 (6%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% | 12.0% 5.9% 3.4% |
|TERMINAL (d) | 0/17 (0%) 1/17 (6%) 0/4 (0%) | 3/25 (12%) 2/34 (6%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) --- | 727 (T) 727 (T) 689 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.724 P=0.500 (e) | P=0.364N P=0.360N P=0.441N |
|INCIDENTAL TUMOR | P=0.724 P=0.500 (e) | P=0.295N P=0.360N P=0.369N |
|LOGISTIC REGRESSION | P=0.724 P=0.500 (e) | P=0.262N P=0.360N P=0.329N |
|COCHRAN-ARMITAGE | P=0.712N | P=0.233N |
|FISHER EXACT | P=0.500 (e) | P=0.490N P=0.301N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/49 (4%) 3/50 (6%) | 6/49 (12%) 8/50 (16%) 5/50 (10%) |
|ADJUSTED (b) | 10.7% 11.8% 15.6% | 22.9% 21.5% 25.7% |
|TERMINAL (d) | 1/17 (6%) 2/17 (12%) 0/4 (0%) | 5/25 (20%) 6/34 (18%) 3/15 (20%) |
|FIRST INCIDENCE (DAYS) | 618 727 (T) 629 | 674 563 689 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215 P=0.515N P=0.321 | P=0.462 P=0.604N P=0.509 |
|INCIDENTAL TUMOR | P=0.578N P=0.459N P=0.465N | P=0.504N P=0.519 P=0.616N |
|LOGISTIC REGRESSION | P=0.483 P=0.490N P=0.616 | P=0.441N P=0.522 P=0.542N |
|COCHRAN-ARMITAGE | P=0.591 | P=0.399N |
|FISHER EXACT | P=0.500N P=0.651N | P=0.403 P=0.486N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/49 (0%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.6% 0.0% 2.6% | 0.0% 0.0% 9.2% |
|TERMINAL (d) | 0/17 (0%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 1/15 (7%) |
|FIRST INCIDENCE (DAYS) | 644 --- 548 | --- --- 626 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.577 P=0.522N P=0.674 | P=0.058 (e) P=0.185 |
|INCIDENTAL TUMOR | P=0.500N P=0.455N P=0.522N | P=0.063 (e) P=0.196 |
|LOGISTIC REGRESSION | P=0.683 P=0.507N P=0.736N | P=0.093 (e) P=0.242 |
|COCHRAN-ARMITAGE | P=0.661 | P=0.094 |
|FISHER EXACT | P=0.500N P=0.747N | (e) P=0.253 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 11/50 (22%) 12/50 (24%) 5/50 (10%) |
|ADJUSTED (b) | | 31.0% 32.7% 25.2% |
|TERMINAL (d) | | 5/25 (20%) 10/34 (29%) 3/15 (20%) |
|FIRST INCIDENCE (DAYS) | | 454 428 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.206N P=0.428N P=0.206N |
|INCIDENTAL TUMOR | | P=0.112N P=0.427 P=0.135N |
|LOGISTIC REGRESSION | | P=0.064N P=0.488 P=0.091N |
|COCHRAN-ARMITAGE | | P=0.065N |
|FISHER EXACT | | P=0.500 P=0.086N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 4.8% |
|TERMINAL (d) | | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | | --- --- 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.094 (e) P=0.250 |
|INCIDENTAL TUMOR | | P=0.187 (e) P=0.324 |
|LOGISTIC REGRESSION | | P=0.060 (e) P=0.181 |
|COCHRAN-ARMITAGE | | P=0.092 |
|FISHER EXACT | | (e) P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 11/50 (22%) 13/50 (26%) 5/50 (10%) |
|ADJUSTED (b) | | 31.0% 34.2% 25.2% |
|TERMINAL (d) | | 5/25 (20%) 10/34 (29%) 3/15 (20%) |
|FIRST INCIDENCE (DAYS) | | 454 428 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.202N P=0.515N P=0.206N |
|INCIDENTAL TUMOR | | P=0.108N P=0.340 P=0.135N |
|LOGISTIC REGRESSION | | P=0.064N P=0.379 P=0.091N |
|COCHRAN-ARMITAGE | | P=0.063N |
|FISHER EXACT | | P=0.408 P=0.086N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 9.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/18 (0%) 1/17 (6%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 675 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.610 P=0.249 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.668 P=0.233 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.685 P=0.234 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.614N | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 26/50 (52%) 22/50 (44%) | 18/50 (36%) 10/50 (20%) 7/50 (14%) |
|ADJUSTED (b) | 75.5% 78.7% 79.8% | 45.2% 26.3% 27.8% |
|TERMINAL (d) | 11/18 (61%) 11/17 (65%) 2/4 (50%) | 5/25 (20%) 7/34 (21%) 2/15 (13%) |
|FIRST INCIDENCE (DAYS) | 422 486 497 | 491 545 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.032 * P=0.534N P=0.063 | P=0.040N* P=0.021N* P=0.044N* |
|INCIDENTAL TUMOR | P=0.199N P=0.489N P=0.204N | P=0.002N** P=0.154N P=0.002N** |
|LOGISTIC REGRESSION | P=0.216N P=0.492N P=0.195N | P=0.010N** P=0.067N P=0.012N* |
|COCHRAN-ARMITAGE | P=0.180N | P=0.009N** |
|FISHER EXACT | P=0.500N P=0.212N | P=0.059N P=0.010N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.9% 6.1% 18.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/18 (6%) 0/17 (0%) 0/4 (0%) | 0/25 (0%) 0/34 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 618 560 548 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085 P=0.500N P=0.131 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.436 P=0.465N P=0.507 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.288 P=0.502N P=0.375 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.253 | (e) |
|FISHER EXACT | P=0.500N P=0.357 | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 46/50 (92%) 49/50 (98%) | 37/50 (74%) 42/50 (84%) 37/50 (74%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 92.2% 91.2% 97.0% |
|TERMINAL (d) | 18/18 (100%) 17/17 (100%) 4/4 (100%) | 22/25 (88%) 30/34 (88%) 14/15 (93%) |
|FIRST INCIDENCE (DAYS) | 401 535 497 | 454 428 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.551 P<0.001 ** | P=0.043 * P=0.232N P=0.087 |
|INCIDENTAL TUMOR | P=0.209 P=0.469N P=0.420 | P=0.497 P=0.425 P=0.491 |
|LOGISTIC REGRESSION | P=0.242 P=0.325N P=0.322 | P=0.411N P=0.365 P=0.489N |
|COCHRAN-ARMITAGE | P=0.231 | P=0.494N |
|FISHER EXACT | P=0.500N P=0.309 | P=0.163 P=0.590N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2 PPM 5 PPM | CONTROL 2 PPM 5 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 43/50 (86%) 50/50 (100%) | 24/50 (48%) 31/50 (62%) 50/50 (100%) |
|ADJUSTED (b) | 89.6% 95.3% 100.0% | 58.3% 73.6% 100.0% |
|TERMINAL (d) | 14/18 (78%) 15/17 (88%) 4/4 (100%) | 9/25 (36%) 23/34 (68%) 15/15 (100%) |
|FIRST INCIDENCE (DAYS) | 422 486 497 | 251 545 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.269 P<0.001 ** | P<0.001 ** P=0.557 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.142 P=0.002 ** | P<0.001 ** P=0.060 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.002 ** P=0.164 P<0.001 ** | P<0.001 ** P=0.139 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.154 P<0.001 ** | P=0.114 P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 49/50 (98%) 50/50 (100%) | 47/50 (94%) 49/50 (98%) 50/50 (100%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 97.9% 98.0% 100.0% |
|TERMINAL (d) | 18/18 (100%) 17/17 (100%) 4/4 (100%) | 24/25 (96%) 33/34 (97%) 15/15 (100%) |
|FIRST INCIDENCE (DAYS) | 401 486 497 | 251 428 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.450 P<0.001 ** | P=0.016 * P=0.084N P=0.054 |
|INCIDENTAL TUMOR | P=0.360 P=0.500 P=0.525 | P=0.194 P=0.416 P=0.280 |
|LOGISTIC REGRESSION | P=0.265 P=0.685 P=0.274 | P=0.132 P=0.498 P=0.211 |
|COCHRAN-ARMITAGE | P=0.160 | P=0.075 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.309 P=0.121 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05072 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TETRANITROMETHANE
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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