TR 387 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) DL AMPHETAMINE SULFATE NTP Experiment-Test: 05029-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 Facility: Microbiological Associates Chemical CAS #: 60-13-9 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 10 11 5 Moribund 5 3 1 Survivors Terminal Sacrifice 35 36 44 Animals Examined Microscopically 50 50 47 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (44) (40) (43) Inflammation, Chronic 1 (2%) 1 (3%) Intestine Large, Cecum (44) (44) (44) Hyperplasia, Lymphoid 1 (2%) 5 (11%) Intestine Small, Jejunum (45) (43) (44) Inflammation, Acute 1 (2%) Liver (50) (50) (47) Basophilic Focus 1 (2%) Cytologic Alterations, Focal 1 (2%) Hematopoietic Cell Proliferation 4 (8%) 5 (10%) Inflammation, Acute 3 (6%) 1 (2%) 1 (2%) Inflammation, Chronic 7 (14%) 11 (22%) 7 (15%) Mitotic Alteration 1 (2%) Necrosis 3 (6%) 2 (4%) 1 (2%) Vacuolization Cytoplasmic 5 (10%) Serosa, Inflammation, Acute 1 (2%) 1 (2%) Mesentery (4) (1) Infiltration Cellular, Lymphocyte 1 (100%) Inflammation, Acute 1 (25%) Fat, Necrosis 3 (75%) Pancreas (49) (48) (45) Cyst 1 (2%) Inflammation, Acute 2 (4%) 3 (6%) Inflammation, Chronic 7 (15%) 5 (11%) Acinus, Atrophy, Focal 2 (4%) Acinus, Necrosis 1 (2%) Acinus, Vacuolization Cytoplasmic 2 (4%) 1 (2%) Artery, Inflammation, Acute 1 (2%) Salivary Glands (49) (46) (43) Infiltration Cellular, Lymphocyte 26 (53%) 25 (54%) 21 (49%) Artery, Inflammation, Acute 1 (2%) Stomach, Forestomach (50) (49) (46) Inflammation, Acute 1 (2%) Epithelium, Hyperplasia 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Stomach, Glandular (50) (49) (46) Erosion 1 (2%) Infiltration Cellular, Lymphocyte 1 (2%) Inflammation, Chronic 1 (2%) Ulcer 1 (2%) Tooth (2) (2) (1) Inflammation, Acute 2 (100%) 1 (50%) 1 (100%) Inflammation, Chronic 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (47) Fibrosis 2 (4%) Aortic Valve, Thrombosis 1 (2%) Epicardium, Inflammation, Acute 2 (4%) Myocardium, Inflammation, Chronic 1 (2%) Myocardium, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (46) (47) Capsule, Hyperplasia 50 (100%) 42 (91%) 46 (98%) Adrenal Gland, Cortex (50) (46) (46) Cyst 2 (4%) Hematopoietic Cell Proliferation 2 (4%) Infiltration Cellular, Lymphocyte 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Vacuolization Cytoplasmic 1 (2%) Adrenal Gland, Medulla (48) (43) (43) Hyperplasia 1 (2%) Parathyroid Gland (46) (42) (44) Infiltration Cellular, Lymphocyte 1 (2%) Pituitary Gland (49) (49) (46) Pars Distalis, Angiectasis 1 (2%) Pars Distalis, Hyperplasia 11 (22%) 5 (10%) 3 (7%) Pars Intermedia, Pigmentation 1 (2%) Thyroid Gland (50) (49) (47) Cyst 8 (16%) 9 (18%) 10 (21%) Inflammation, Acute 2 (4%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Follicular Cell, Hyperplasia 8 (16%) 5 (10%) 3 (6%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (49) (48) (46) Abscess 2 (4%) Atrophy 14 (29%) 12 (25%) 25 (54%) Cyst 11 (22%) 16 (33%) 12 (26%) Hemorrhage 3 (6%) 1 (2%) Infiltration Cellular, Lymphocyte 2 (4%) Inflammation, Acute 1 (2%) 4 (8%) Inflammation, Chronic 1 (2%) Uterus (50) (50) (47) Abscess 2 (4%) Hemorrhage 1 (2%) Inflammation, Acute 8 (16%) 10 (20%) 4 (9%) Artery, Inflammation, Acute 1 (2%) 1 (2%) Cervix, Inflammation, Chronic 1 (2%) Endometrium, Hyperplasia, Cystic 35 (70%) 34 (68%) 34 (72%) Endometrium, Necrosis 1 (2%) Serosa, Inflammation, Acute 1 (2%) Serosa, Inflammation, Chronic 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (47) Hyperplasia 6 (12%) 6 (12%) Lymph Node (50) (49) (47) Iliac, Hyperplasia, Lymphoid 2 (4%) Mediastinal, Abscess 1 (2%) Lymph Node, Mandibular (47) (43) (41) Cyst 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) Pigmentation 1 (2%) Thrombosis 1 (2%) Lymphocyte, Necrosis 1 (2%) Lymph Node, Mesenteric (50) (46) (40) Dilatation 1 (2%) Hematopoietic Cell Proliferation 2 (4%) Hyperplasia, Lymphoid 8 (16%) 4 (9%) 1 (3%) Lymphocyte, Necrosis 1 (2%) 2 (4%) Spleen (50) (49) (46) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Amyloid Deposition 1 (2%) Hematopoietic Cell Proliferation 8 (16%) 5 (10%) 1 (2%) Hyperplasia, Lymphoid 6 (12%) 5 (10%) 2 (4%) Lymphocyte, Necrosis 1 (2%) 1 (2%) Thymus (46) (46) (45) Atrophy 8 (17%) 1 (2%) 14 (31%) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (47) Abscess 1 (2%) Foreign Body 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (47) Fibrous Osteodystrophy 18 (36%) 11 (22%) 11 (23%) Metatarsal, Inflammation, Acute 1 (2%) Skeletal Muscle (5) (1) Inflammation, Acute 1 (20%) Inflammation, Chronic 2 (40%) Artery, Inflammation, Acute 1 (20%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (47) Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 3 (6%) Thrombosis 1 (2%) Meninges, Infiltration Cellular, Lymphocyte 1 (2%) 3 (6%) 2 (4%) Thalamus, Mineralization 14 (28%) 7 (14%) 17 (36%) Spinal Cord (49) (46) (43) Meninges, Infiltration Cellular, Lymphocyte 1 (2%) 7 (15%) 8 (19%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (47) Congestion 1 (2%) 3 (6%) Hemorrhage 1 (2%) 1 (2%) Hyperplasia, Adenomatous 1 (2%) 2 (4%) Infiltration Cellular 1 (2%) Infiltration Cellular, Lymphocyte 29 (58%) 36 (72%) 36 (77%) Infiltration Cellular, Histiocyte 1 (2%) 3 (6%) 1 (2%) Inflammation, Chronic 1 (2%) Metaplasia, Osseous 1 (2%) Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%) 1 (2%) Interstitium, Inflammation, Subacute 1 (2%) Pleura, Inflammation, Acute 1 (2%) 2 (4%) Nose (50) (50) (47) Hemorrhage 1 (2%) Nasolacrimal Duct, Inflammation 1 (2%) Nasolacrimal Duct, Inflammation, Acute 1 (2%) Sinus, Inflammation, Acute 1 (2%) Trachea (50) (50) (47) Inflammation, Acute 1 (2%) Artery, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (47) (44) (45) Cataract 1 (2%) Cornea, Inflammation, Acute 2 (5%) Harderian Gland (7) (2) Hyperplasia 1 (14%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (48) (47) Amyloid Deposition 1 (2%) Inflammation, Acute 2 (4%) Inflammation, Chronic 16 (32%) 23 (48%) 14 (30%) Glomerulus, Inflammation, Membranous 1 (2%) Pelvis, Inflammation, Acute 1 (2%) Renal Tubule, Degeneration 1 (2%) Ureter (1) Inflammation, Acute 1 (100%) Urinary Bladder (48) (47) (45) Infiltration Cellular, Lymphocyte 18 (38%) 13 (28%) 11 (24%) Inflammation, Acute 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Artery, Inflammation, Acute 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 2 1 1 Accident 1 Survivors Terminal Sacrifice 48 48 49 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (48) (48) (48) Inflammation, Chronic 2 (4%) Intestine Large, Cecum (49) (48) (50) Hyperplasia, Lymphoid 1 (2%) 2 (4%) Intestine Large, Rectum (47) (46) (50) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) Intestine Small, Duodenum (49) (48) (50) Hyperplasia, Lymphoid 1 (2%) Intestine Small, Ileum (49) (48) (50) Amyloid Deposition 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Intestine Small, Jejunum (49) (48) (50) Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic 1 (2%) Liver (50) (50) (50) Basophilic Focus 3 (6%) Clear Cell Focus 1 (2%) Cyst 1 (2%) Cytologic Alterations, Focal 4 (8%) 3 (6%) Fibrosis, Focal 1 (2%) Inflammation, Acute 1 (2%) 1 (2%) Inflammation, Chronic 8 (16%) 3 (6%) Necrosis, Focal 1 (2%) Centrilobular, Vacuolization Cytoplasmic 1 (2%) Mesentery (1) (3) Fat, Necrosis 1 (100%) 1 (33%) Pancreas (50) (50) (50) Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%) Acinus, Inflammation, Chronic 1 (2%) Acinus, Vacuolization Cytoplasmic 1 (2%) Salivary Glands (50) (50) (49) Infiltration Cellular, Lymphocyte 38 (76%) 27 (54%) 15 (31%) Inflammation, Chronic Active 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Artery, Inflammation, Chronic 1 (2%) 3 (6%) Stomach, Glandular (49) (50) (50) Cyst 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Tooth (5) (5) Developmental Malformation 1 (20%) 4 (80%) Inflammation, Acute 3 (60%) 1 (20%) Inflammation, Chronic Active 1 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Aorta, Inflammation, Chronic 1 (100%) Heart (50) (50) (50) Inflammation, Chronic 1 (2%) Atrium, Bacterium 1 (2%) Atrium, Thrombosis 1 (2%) Myocardium, Infarct 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (49) (49) Capsule, Hyperplasia 28 (56%) 32 (65%) 36 (73%) Adrenal Gland, Cortex (50) (49) (49) Hyperplasia 2 (4%) 3 (6%) Hypertrophy 3 (6%) 1 (2%) Hypertrophy, Focal 5 (10%) 2 (4%) 2 (4%) Capsule, Hyperplasia 1 (2%) Islets, Pancreatic (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (42) (44) (41) Cyst 1 (2%) Pituitary Gland (48) (49) (50) Pars Distalis, Cyst 1 (2%) 2 (4%) 1 (2%) Pars Distalis, Hyperplasia 1 (2%) Thyroid Gland (50) (50) (50) Cyst 7 (14%) 6 (12%) 7 (14%) Inflammation, Chronic 1 (2%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) Inflammation, Chronic 1 (2%) 2 (4%) 3 (6%) Preputial Gland (1) (1) Cyst 1 (100%) Inflammation, Acute 1 (100%) Prostate (50) (50) (49) Inflammation, Chronic 3 (6%) 2 (4%) Seminal Vesicle (50) (50) (50) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Testes (50) (50) (50) Atrophy 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (50) (50) (50) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Lymph Node, Mandibular (41) (44) (45) Hyperplasia, Lymphoid 2 (4%) Lymph Node, Mesenteric (47) (49) (48) Amyloid Deposition 1 (2%) Hematopoietic Cell Proliferation 2 (4%) Hemorrhage 2 (4%) 1 (2%) Hyperplasia, Lymphoid 4 (9%) 4 (8%) Spleen (48) (50) (50) Depletion Lymphoid 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Thymus (44) (44) (41) Cyst 2 (5%) 1 (2%) Epithelial Cell, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) Inflammation, Acute 2 (4%) Inflammation, Chronic 2 (4%) 1 (2%) Subcutaneous Tissue, Abscess 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Tail, Inflammation, Chronic 1 (2%) Tail, Epidermis, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) Fibrous Osteodystrophy 1 (2%) 1 (2%) Osteomalacia 1 (2%) Cranium, Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Infiltration Cellular, Lymphocyte 1 (2%) Choroid Plexus, Infiltration Cellular, Lymphocyte 1 (2%) Meninges, Infiltration Cellular, Lymphocyte 1 (2%) Thalamus, Mineralization 43 (86%) 33 (66%) 36 (72%) Spinal Cord (49) (50) (50) Infiltration Cellular, Lymphocyte 1 (2%) Meninges, Infiltration Cellular, Lymphocyte 3 (6%) 4 (8%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) Inflammation, Acute 1 (2%) Lung (50) (50) (50) Congestion 1 (2%) Fibrosis, Focal 1 (2%) Hemorrhage 2 (4%) Hyperplasia, Adenomatous 3 (6%) 3 (6%) Infiltration Cellular, Lymphocyte 39 (78%) 30 (60%) 33 (66%) Infiltration Cellular, Histiocyte 4 (8%) Inflammation, Acute 1 (2%) Pigmentation 1 (2%) Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%) 1 (2%) Interstitium, Inflammation, Chronic 1 (2%) Nose (50) (50) (50) Glands, Inflammation, Acute 1 (2%) Nasolacrimal Duct, Inflammation, Acute 2 (4%) Sinus, Hemorrhage 1 (2%) Sinus, Inflammation, Acute 2 (4%) 1 (2%) Turbinate, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94 Route: DOSED FEED Time: 12:33:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F CONTROL 20PPM 100 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (49) (49) (50) Cornea, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Cyst 2 (4%) 3 (6%) 1 (2%) Fibrosis, Focal 1 (2%) Inflammation, Chronic 34 (68%) 25 (50%) 27 (54%) Metaplasia, Osseous 1 (2%) 1 (2%) Artery, Inflammation, Chronic 1 (2%) Cortex, Cyst 1 (2%) Cortex, Necrosis, Focal 1 (2%) Papilla, Bacterium 1 (2%) Papilla, Necrosis 1 (2%) Pelvis, Dilatation 1 (2%) Renal Tubule, Hyperplasia 1 (2%) Renal Tubule, Regeneration 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 74493-74493/74493 --multipart-boundary--