TR 387 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DL AMPHETAMINE SULFATE
NTP Experiment-Test: 05029-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
Facility: Microbiological Associates
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 10 11 5
Moribund 5 3 1
Survivors
Terminal Sacrifice 35 36 44
Animals Examined Microscopically 50 50 47
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (40) (43)
Inflammation, Chronic 1 (2%) 1 (3%)
Intestine Large, Cecum (44) (44) (44)
Hyperplasia, Lymphoid 1 (2%) 5 (11%)
Intestine Small, Jejunum (45) (43) (44)
Inflammation, Acute 1 (2%)
Liver (50) (50) (47)
Basophilic Focus 1 (2%)
Cytologic Alterations, Focal 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 5 (10%)
Inflammation, Acute 3 (6%) 1 (2%) 1 (2%)
Inflammation, Chronic 7 (14%) 11 (22%) 7 (15%)
Mitotic Alteration 1 (2%)
Necrosis 3 (6%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 5 (10%)
Serosa, Inflammation, Acute 1 (2%) 1 (2%)
Mesentery (4) (1)
Infiltration Cellular, Lymphocyte 1 (100%)
Inflammation, Acute 1 (25%)
Fat, Necrosis 3 (75%)
Pancreas (49) (48) (45)
Cyst 1 (2%)
Inflammation, Acute 2 (4%) 3 (6%)
Inflammation, Chronic 7 (15%) 5 (11%)
Acinus, Atrophy, Focal 2 (4%)
Acinus, Necrosis 1 (2%)
Acinus, Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Artery, Inflammation, Acute 1 (2%)
Salivary Glands (49) (46) (43)
Infiltration Cellular, Lymphocyte 26 (53%) 25 (54%) 21 (49%)
Artery, Inflammation, Acute 1 (2%)
Stomach, Forestomach (50) (49) (46)
Inflammation, Acute 1 (2%)
Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (50) (49) (46)
Erosion 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Tooth (2) (2) (1)
Inflammation, Acute 2 (100%) 1 (50%) 1 (100%)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (47)
Fibrosis 2 (4%)
Aortic Valve, Thrombosis 1 (2%)
Epicardium, Inflammation, Acute 2 (4%)
Myocardium, Inflammation, Chronic 1 (2%)
Myocardium, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (46) (47)
Capsule, Hyperplasia 50 (100%) 42 (91%) 46 (98%)
Adrenal Gland, Cortex (50) (46) (46)
Cyst 2 (4%)
Hematopoietic Cell Proliferation 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (48) (43) (43)
Hyperplasia 1 (2%)
Parathyroid Gland (46) (42) (44)
Infiltration Cellular, Lymphocyte 1 (2%)
Pituitary Gland (49) (49) (46)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 5 (10%) 3 (7%)
Pars Intermedia, Pigmentation 1 (2%)
Thyroid Gland (50) (49) (47)
Cyst 8 (16%) 9 (18%) 10 (21%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 8 (16%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (48) (46)
Abscess 2 (4%)
Atrophy 14 (29%) 12 (25%) 25 (54%)
Cyst 11 (22%) 16 (33%) 12 (26%)
Hemorrhage 3 (6%) 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation, Acute 1 (2%) 4 (8%)
Inflammation, Chronic 1 (2%)
Uterus (50) (50) (47)
Abscess 2 (4%)
Hemorrhage 1 (2%)
Inflammation, Acute 8 (16%) 10 (20%) 4 (9%)
Artery, Inflammation, Acute 1 (2%) 1 (2%)
Cervix, Inflammation, Chronic 1 (2%)
Endometrium, Hyperplasia, Cystic 35 (70%) 34 (68%) 34 (72%)
Endometrium, Necrosis 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (47)
Hyperplasia 6 (12%) 6 (12%)
Lymph Node (50) (49) (47)
Iliac, Hyperplasia, Lymphoid 2 (4%)
Mediastinal, Abscess 1 (2%)
Lymph Node, Mandibular (47) (43) (41)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Lymphocyte, Necrosis 1 (2%)
Lymph Node, Mesenteric (50) (46) (40)
Dilatation 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Lymphoid 8 (16%) 4 (9%) 1 (3%)
Lymphocyte, Necrosis 1 (2%) 2 (4%)
Spleen (50) (49) (46)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Amyloid Deposition 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 5 (10%) 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 5 (10%) 2 (4%)
Lymphocyte, Necrosis 1 (2%) 1 (2%)
Thymus (46) (46) (45)
Atrophy 8 (17%) 1 (2%) 14 (31%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (47)
Abscess 1 (2%)
Foreign Body 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (47)
Fibrous Osteodystrophy 18 (36%) 11 (22%) 11 (23%)
Metatarsal, Inflammation, Acute 1 (2%)
Skeletal Muscle (5) (1)
Inflammation, Acute 1 (20%)
Inflammation, Chronic 2 (40%)
Artery, Inflammation, Acute 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (47)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%) 3 (6%) 2 (4%)
Thalamus, Mineralization 14 (28%) 7 (14%) 17 (36%)
Spinal Cord (49) (46) (43)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%) 7 (15%) 8 (19%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (47)
Congestion 1 (2%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Adenomatous 1 (2%) 2 (4%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Lymphocyte 29 (58%) 36 (72%) 36 (77%)
Infiltration Cellular, Histiocyte 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%) 1 (2%)
Interstitium, Inflammation, Subacute 1 (2%)
Pleura, Inflammation, Acute 1 (2%) 2 (4%)
Nose (50) (50) (47)
Hemorrhage 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Sinus, Inflammation, Acute 1 (2%)
Trachea (50) (50) (47)
Inflammation, Acute 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (47) (44) (45)
Cataract 1 (2%)
Cornea, Inflammation, Acute 2 (5%)
Harderian Gland (7) (2)
Hyperplasia 1 (14%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (47)
Amyloid Deposition 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 16 (32%) 23 (48%) 14 (30%)
Glomerulus, Inflammation, Membranous 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Ureter (1)
Inflammation, Acute 1 (100%)
Urinary Bladder (48) (47) (45)
Infiltration Cellular, Lymphocyte 18 (38%) 13 (28%) 11 (24%)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Artery, Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 2 1 1
Accident 1
Survivors
Terminal Sacrifice 48 48 49
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (48) (48)
Inflammation, Chronic 2 (4%)
Intestine Large, Cecum (49) (48) (50)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Intestine Large, Rectum (47) (46) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (49) (48) (50)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (49) (48) (50)
Amyloid Deposition 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Jejunum (49) (48) (50)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 3 (6%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%)
Cytologic Alterations, Focal 4 (8%) 3 (6%)
Fibrosis, Focal 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 8 (16%) 3 (6%)
Necrosis, Focal 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Mesentery (1) (3)
Fat, Necrosis 1 (100%) 1 (33%)
Pancreas (50) (50) (50)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Acinus, Inflammation, Chronic 1 (2%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Salivary Glands (50) (50) (49)
Infiltration Cellular, Lymphocyte 38 (76%) 27 (54%) 15 (31%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (2%) 3 (6%)
Stomach, Glandular (49) (50) (50)
Cyst 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Tooth (5) (5)
Developmental Malformation 1 (20%) 4 (80%)
Inflammation, Acute 3 (60%) 1 (20%)
Inflammation, Chronic Active 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic 1 (100%)
Heart (50) (50) (50)
Inflammation, Chronic 1 (2%)
Atrium, Bacterium 1 (2%)
Atrium, Thrombosis 1 (2%)
Myocardium, Infarct 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (49)
Capsule, Hyperplasia 28 (56%) 32 (65%) 36 (73%)
Adrenal Gland, Cortex (50) (49) (49)
Hyperplasia 2 (4%) 3 (6%)
Hypertrophy 3 (6%) 1 (2%)
Hypertrophy, Focal 5 (10%) 2 (4%) 2 (4%)
Capsule, Hyperplasia 1 (2%)
Islets, Pancreatic (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (42) (44) (41)
Cyst 1 (2%)
Pituitary Gland (48) (49) (50)
Pars Distalis, Cyst 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50)
Cyst 7 (14%) 6 (12%) 7 (14%)
Inflammation, Chronic 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Inflammation, Chronic 1 (2%) 2 (4%) 3 (6%)
Preputial Gland (1) (1)
Cyst 1 (100%)
Inflammation, Acute 1 (100%)
Prostate (50) (50) (49)
Inflammation, Chronic 3 (6%) 2 (4%)
Seminal Vesicle (50) (50) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Testes (50) (50) (50)
Atrophy 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mandibular (41) (44) (45)
Hyperplasia, Lymphoid 2 (4%)
Lymph Node, Mesenteric (47) (49) (48)
Amyloid Deposition 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hemorrhage 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 4 (9%) 4 (8%)
Spleen (48) (50) (50)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Thymus (44) (44) (41)
Cyst 2 (5%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Tail, Inflammation, Chronic 1 (2%)
Tail, Epidermis, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Osteomalacia 1 (2%)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Choroid Plexus, Infiltration Cellular,
Lymphocyte 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%)
Thalamus, Mineralization 43 (86%) 33 (66%) 36 (72%)
Spinal Cord (49) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50)
Inflammation, Acute 1 (2%)
Lung (50) (50) (50)
Congestion 1 (2%)
Fibrosis, Focal 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia, Adenomatous 3 (6%) 3 (6%)
Infiltration Cellular, Lymphocyte 39 (78%) 30 (60%) 33 (66%)
Infiltration Cellular, Histiocyte 4 (8%)
Inflammation, Acute 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%)
Nose (50) (50) (50)
Glands, Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 2 (4%)
Sinus, Hemorrhage 1 (2%)
Sinus, Inflammation, Acute 2 (4%) 1 (2%)
Turbinate, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (49) (50)
Cornea, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 2 (4%) 3 (6%) 1 (2%)
Fibrosis, Focal 1 (2%)
Inflammation, Chronic 34 (68%) 25 (50%) 27 (54%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Cortex, Cyst 1 (2%)
Cortex, Necrosis, Focal 1 (2%)
Papilla, Bacterium 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Regeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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