TR 387 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DL AMPHETAMINE SULFATE
NTP Experiment-Test: 05029-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
Facility: Microbiological Associates
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 10 11 5
Moribund 5 3 1
Survivors
Terminal Sacrifice 35 36 44
Animals Examined Microscopically 50 50 47
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (44) (44) (44)
Intestine Small, Jejunum (45) (43) (44)
Liver (50) (50) (47)
Hemangiosarcoma 1 (2%)
Hepatocellular Adenoma 5 (10%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Pancreas (49) (48) (45)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (49) (46) (43)
Stomach, Forestomach (50) (49) (46)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (49) (46)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (47)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (46) (46)
Adrenal Gland, Medulla (48) (43) (43)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Benign 1 (2%)
Parathyroid Gland (46) (42) (44)
Pituitary Gland (49) (49) (46)
Pars Distalis, Adenoma 12 (24%) 6 (12%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (49) (47)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (48) (46)
Cystadenoma 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Neoplasm NOS 1 (2%)
Uterus (50) (50) (47)
Histiocytic Sarcoma 2 (4%)
Cervix, Fibrosarcoma 1 (2%)
Cervix, Leiomyoma 1 (2%)
Endometrium, Polyp Stromal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (47)
Lymph Node (50) (49) (47)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (47) (43) (41)
Histiocytic Sarcoma 2 (4%)
Lymph Node, Mesenteric (50) (46) (40)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (49) (46)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 3 (6%)
Thymus (46) (46) (45)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (45)
Adenocarcinoma 1 (2%) 1 (2%)
Adenoma 1 (2%) 1 (2%)
Skin (50) (50) (47)
Melanoma Benign 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (47)
Joint, Neoplasm NOS 1 (2%)
Skeletal Muscle (5) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (47)
Spinal Cord (49) (46) (43)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (47)
Lung (50) (50) (47)
Alveolar/Bronchiolar Adenoma 7 (14%) 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Ear 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Nose (50) (50) (47)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Fibrous Histiocytoma 1 (100%)
Harderian Gland (7) (2)
Adenoma 5 (71%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (47)
Histiocytic Sarcoma 1 (2%) 3 (6%)
Urinary Bladder (48) (47) (45)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(47)
Histiocytic Sarcoma 2 (4%) 3 (6%)
Lymphoma Malignant 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 4 (8%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 2 (4%)
Lymphoma Malignant Mixed 10 (20%) 9 (18%) 7 (15%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(47)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 27 15
Total Primary Neoplasms 60 39 18
Total Animals with Benign Neoplasms 30 13 5
Total Benign Neoplasms 37 19 5
Total Animals with Malignant Neoplasms 19 17 11
Total Malignant Neoplasms 23 19 12
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 2 1 1
Accident 1
Survivors
Terminal Sacrifice 48 48 49
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (48) (48)
Adenoma, Papillary 1 (2%) 1 (2%)
Intestine Large, Cecum (49) (48) (50)
Intestine Small, Duodenum (49) (48) (50)
Intestine Small, Ileum (49) (48) (50)
Intestine Small, Jejunum (49) (48) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50)
Hemangiosarcoma 3 (6%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 4 (8%) 5 (10%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 10 (20%) 7 (14%) 1 (2%)
Mesentery (1) (3)
Hemangiosarcoma 1 (33%)
Pancreas (50) (50) (50)
Salivary Glands (50) (50) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (49)
Capsule, Adenoma 4 (8%) 1 (2%)
Adrenal Gland, Cortex (50) (49) (49)
Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (49) (47)
Neuroblastoma Benign 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Page 7
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%)
Thyroid Gland (50) (50) (50)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Seminal Vesicle (50) (50) (50)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (41) (44) (45)
Lymph Node, Mesenteric (47) (49) (48)
Spleen (48) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (44) (44) (41)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Spinal Cord (49) (50) (50)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (2)
Adenoma 4 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Mixed 4 (8%) 5 (10%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05029-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 12:33:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 25 18
Total Primary Neoplasms 41 33 18
Total Animals with Benign Neoplasms 23 15 9
Total Benign Neoplasms 26 16 9
Total Animals with Malignant Neoplasms 13 17 9
Total Malignant Neoplasms 15 17 9
Total Animals with Metastatic Neoplasms 2 3
Total Metastatic Neoplasm 2 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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