TR 387 Mouse Pathology Tables
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
Facility: BIORELIANCE
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + A + + + + + A + + + + + + + + + A + + + + A|
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + A + + + + + + + + + A + + + A +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + A +|
Inflammation, Acute | 4|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Cytologic Alterations, Focal | |
Hematopoietic Cell Proliferation | 2 1 |
Inflammation, Acute | 2 1 |
Inflammation, Chronic | 1 2 1 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 2 1 2 2|
Serosa, Inflammation, Acute | |
|__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | |
Fat, Necrosis | 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | |
Acinus, Atrophy, Focal | 1 |
Acinus, Necrosis | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 1 1 1 1 1 2 1 1 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
|__________________________________________________________________________|
Tooth | + + |
Inflammation, Acute | 4 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 1 1 2 2 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 1 1|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 |
Pars Intermedia, Pigmentation | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | 1 2 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +|
Abscess | 4 4 |
Atrophy | 2 2 2 2 2 2 2 2 |
Cyst | 3 4 4 4 2 2 |
Hemorrhage | 3 4 |
Inflammation, Acute | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Acute | 1 3 3 2 3|
Cervix, Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 3 3 2 2 1 3 2 2 3 2 2 3 2 2 3 2 |
Serosa, Inflammation, Acute | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 3 4 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Mediastinal, Abscess | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + M + + + + + + + + + + + + + + M +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Thrombosis | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 2 2 3 3|
Lymphocyte, Necrosis | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 2 2 2 4 2 |
Hyperplasia, Lymphoid | 2 2 3|
Lymphocyte, Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + M + + + M + +|
Atrophy | 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Fibrous Osteodystrophy | 1 2 1 1 2 2 2 1 1 2 |
Metatarsal, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
Thalamus, Mineralization | 1 1 1 1 1 |
|__________________________________________________________________________|
Spinal Cord | + + + + M + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Hemorrhage | |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular | |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 2 2 2 1 1 2 1 2 2 2 1 |
Infiltration Cellular, Histiocyte | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | |
Pleura, Inflammation, Acute | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| 3| 2| 1|
| 2| 2| 2| 1| 3| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 8| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 |
|__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 1 1 1 |
Pelvis, Inflammation, Acute | |
|__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 |
Inflammation, Acute | |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + + + + + + + + + A + + + + +| 44 |
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + A + + + + +| 44 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + A + + + + +| 45 |
Inflammation, Acute | | 1 4.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 2.0|
Cytologic Alterations, Focal | X | 1 |
Hematopoietic Cell Proliferation | 2 2 | 4 1.8|
Inflammation, Acute | 1 | 3 1.3|
Inflammation, Chronic | 1 1 1 | 7 1.1|
Necrosis | 3 2 | 3 2.3|
Vacuolization Cytoplasmic | | 5 1.8|
Serosa, Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + | 4 |
Inflammation, Acute | 4 | 1 4.0|
Fat, Necrosis | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Inflammation, Acute | 4 4 | 2 4.0|
Acinus, Atrophy, Focal | 1 | 2 1.0|
Acinus, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 2 1 1 2 2 1 2 2 2 1 1| 26 1.4|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation, Acute | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Chronic | | |
Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Capsule, Hyperplasia | 1 2 2 2 2 2 2 2 1 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2| 50 1.8|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + M M + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Hyperplasia | 2 1 2 2 | 11 1.9|
Pars Intermedia, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 1 2 | 8 1.9|
Inflammation, Acute | 2 | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Follicular Cell, Hyperplasia | 2 2 1 4 | 8 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 2 4.0|
Atrophy | 2 2 2 2 2 2 | 14 2.0|
Cyst | X 4 3 2 3 | 11 3.1|
Hemorrhage | 4 | 3 3.7|
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 2 3| 2 2.5|
Inflammation, Acute | 2 2 4 | 8 2.5|
Cervix, Inflammation, Chronic | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 2 2 2 1 3 2 2 1 2 4 2 2 2 2 2 2| 35 2.2|
Serosa, Inflammation, Acute | 3 | 1 3.0|
Serosa, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 6 3.2|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 2 | 2 2.0|
Mediastinal, Abscess | 3| 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 8 2.4|
Lymphocyte, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 4 2 | 8 2.5|
Hyperplasia, Lymphoid | 2 2 2 | 6 2.2|
Lymphocyte, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 2 2 2 2| 8 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 1 2 2 2 1 1 | 18 1.6|
Metatarsal, Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Thalamus, Mineralization | 1 1 2 2 1 2 2 2 1| 14 1.4|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Adenomatous | | 1 1.0|
Infiltration Cellular | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 2 2 3 2 2 2 2 3 2 1 2| 29 1.7|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 2 | 1 2.0|
Pleura, Inflammation, Acute | 3| 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
Cataract | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 7 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 2 2 1 1 1 1 2 2 1 | 16 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| |
| 2| 2| 1| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 4| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pelvis, Inflammation, Acute | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 2 2 | 18 1.2|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + A A + + + + + + + + + + + + + + A|
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + A + A|
Hyperplasia, Lymphoid | 2 2 2 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + + + M + + + + A + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 1 1 1 2 1 |
Necrosis | |
Serosa, Inflammation, Acute | |
|__________________________________________________________________________|
Mesentery | |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 |
Acinus, Vacuolization Cytoplasmic | 2 2 |
Artery, Inflammation, Acute | |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + M + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 1 2 1 1 1 1 |
Artery, Inflammation, Acute | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Aortic Valve, Thrombosis | |
Epicardium, Inflammation, Acute | |
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + M + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + M + + + + + +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + M M + + + + M|
Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 1 2 |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2|
Cyst | 2 2 2 2 2 2 |
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 2 2 4 |
Artery, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 |
Serosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + M M + + + + + + M + + + + + M +|
Cyst | |
Hyperplasia, Lymphoid | |
Pigmentation | |
Lymphocyte, Necrosis | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + M + + + + + + A|
Hyperplasia, Lymphoid | 2 2 |
Lymphocyte, Necrosis | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Lymphocyte, Necrosis | |
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Acute | |
Mineralization | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 2 1|
|__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Artery, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Thrombosis | |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 1 |
Thalamus, Mineralization | |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + M + + + + M|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Lymphocyte | 3 2 2 2 2 2 1 2 1 3 2 2 2 2 2 3 1 2 2 1 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Chronic | |
Pleura, Inflammation, Acute | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + A + + + + + + + + + M + + A + M|
Cornea, Inflammation, Acute | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 1| 3| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 1 1 3 1 1 1 1 1 1 |
Glomerulus, Inflammation, Membranous | |
|__________________________________________________________________________|
Ureter | |
Inflammation, Acute | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + A + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 1 2 1 |
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + M + A + + M + + A + + + + + + M + + A + + + + A| 40 |
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A + + + + A + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + A + + + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2| 5 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 1 1 1 | 11 1.1|
Necrosis | 2 2 | 2 2.0|
Serosa, Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Acute | 2 2 4| 3 2.7|
Inflammation, Chronic | 1 2 1 | 7 1.1|
Acinus, Vacuolization Cytoplasmic | | 2 2.0|
Artery, Inflammation, Acute | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + M + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | 2 2 1 1 1 2 2 1 1 2 1 1 2 1 | 25 1.4|
Artery, Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 2 1.5|
Aortic Valve, Thrombosis | 3 | 1 3.0|
Epicardium, Inflammation, Acute | 3 2| 2 2.5|
Myocardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + M + + + +| 46 |
Capsule, Hyperplasia | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| 42 1.9|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + M + + + +| 46 |
Hematopoietic Cell Proliferation | 2 2| 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + M + + + + + + + + + + + M + + + +| 43 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + M M + + + + M M + + + + +| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Pars Distalis, Hyperplasia | 1 2 | 5 1.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Cyst | 2 2 2 2 2 | 9 1.8|
Inflammation, Chronic | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 3 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 2 2 2 2 | 12 2.0|
Cyst | 1 1 2 2 2 X 2 1 2 2 | 16 1.8|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Inflammation, Acute | 2 4 3 3| 4 3.0|
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 4 4 4 4 4 4| 10 3.4|
Artery, Inflammation, Acute | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 1 2 2 2 2 2 3 3 2 2 2 2 | 34 2.0|
Serosa, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 4 2 | 6 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + M + + + + + + + + + + + + + + +| 43 |
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Pigmentation | 2 | 1 2.0|
Lymphocyte, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Lymphocyte, Necrosis | 2 2| 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 4 2 3 3| 5 2.8|
Hyperplasia, Lymphoid | 1 | 5 1.8|
Lymphocyte, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M + + + + + + + + + + + + + M +| 46 |
Atrophy | | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
Mineralization | | 1 3.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 1 2 2 | 11 1.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 5 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | 2 | 2 1.5|
Artery, Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Thrombosis | 2 | 1 2.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 | 3 1.7|
Thalamus, Mineralization | 2 2 1 2 1 1 1| 7 1.4|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 2 1 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 0| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 3| 3| 4| 1| 0| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Adenomatous | 2 | 2 1.5|
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 2 2 2 1 1 2 1 1 1 2 1 | 36 1.8|
Infiltration Cellular, Histiocyte | 2 | 3 1.3|
Inflammation, Chronic | 2 | 1 2.0|
Pleura, Inflammation, Acute | 3 2| 2 2.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + A + + + + +| 44 |
Cornea, Inflammation, Acute | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | | 1 3.0|
Inflammation, Acute | 4 2| 2 3.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 23 1.1|
Glomerulus, Inflammation, Membranous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ureter | + | 1 |
Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 1 | 13 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 5| 5|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Mitotic Alteration | |
Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic | 2 |
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 1 1 2 1 1 1 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 5| 5|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Erosion | 2 |
|__________________________________________________________________________|
Tooth | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 3 1 1|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + M + + + + + M + + + + + + M + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Hyperplasia | 1 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 5| 5|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Atrophy | 2 2 2 2 2 2 1 3 2 2 3 2 |
Cyst | 3 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Acute | 2 |
Artery, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 2 2 2 1 3 2 2 2 3 2 2 2 2 3 2 2 2 2 2 |
Endometrium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + M + + + + + + + + + M|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + A M|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + M +|
Atrophy | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 5| 5|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 2 2 1 2 1 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization | 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + M + + + + + + + + + + + + M M|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 1 2 2 1 2 3 1 2 1 1 1 2 1 |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | |
Interstitium, Inflammation, Subacute | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Inflammation, Acute | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 5| 5|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 2 1 1 1 1 |
Renal Tubule, Degeneration | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 |
Artery, Inflammation, Acute | |
__________________________________________|__________________________________________________________________________
Page 31
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 2| 2| 2| 4| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 1 | 7 1.1|
Mitotic Alteration | 2 | 1 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic | 1 1 1 1 | 5 1.2|
Acinus, Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + M + M + + + + + + + + + +| 43 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 2 1 2| 21 1.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 2| 2| 2| 4| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach | + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Erosion | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Capsule, Hyperplasia | 3 2 1 1 2 2 2 2 2 2 3 2 2 2 2 2 1 2 2 2 2 2| 46 1.9|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + M +| 44 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia | | 3 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 1 2 3 3 2 2 2 | 10 2.1|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 2| 2| 2| 4| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicular Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 1 2 2 2 2 2 2 2 1 2 1 2 1 | 25 1.9|
Cyst | 3 2 2 3 2 3 2 2 | 12 2.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | 1 2 1 | 4 1.5|
Artery, Inflammation, Acute | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 3 2 1 2 2 2 2 3| 34 2.1|
Endometrium, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + M + M + + + + + + + + + +| 41 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M M M + + + + M| 40 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 | 2 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 2| 2| 2| 4| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + + + + + + + + + + + + +| 45 |
Atrophy | 2 2 2 2 2 2 2 2| 14 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrous Osteodystrophy | 2 1 2 | 11 1.6|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Lymphocyte | 1 | 3 1.3|
Meninges, Infiltration Cellular, | | |
Lymphocyte | 1 2 | 2 1.5|
Thalamus, Mineralization | 1 1 1 1 2 1 1 1 1 | 17 1.1|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + A + + + + + + + + + + + + + + + + +| 43 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 1 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 2| 2| 2| 4| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Congestion | 2 | 3 2.7|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 1 2 2 2 1 1 1 2 1 1| 36 1.6|
Infiltration Cellular, Histiocyte | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 1 | 1 1.0|
Interstitium, Inflammation, Subacute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 | 1 1.0|
Sinus, Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + A + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 1 1 2 3 1 1 | 14 1.4|
Renal Tubule, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + +| 45 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 11 1.0|
Artery, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Cytologic Alterations, Focal | X X X |
Fibrosis, Focal | 2 |
Inflammation, Chronic | 1 1 2 1|
Necrosis, Focal | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | 1 |
Acinus, Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Inflammation, Chronic | |
|__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 2 1 1 2 1 1 1 1 1 3 1|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Hypertrophy, Focal | 2 2 2 1 |
Hypertrophy | |
Capsule, Hyperplasia | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + + + M + + + + + + M + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Preputial Gland | |
Cyst | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + M + M M + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + A + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | M + + + + M + + + + + + + + + + + + M + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Tail, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Thalamus, Mineralization | 1 2 1 1 1 2 2 2 2 1 2 2 2 1 2 2 1 2 1 2 2 1 2|
|__________________________________________________________________________|
Spinal Cord | + + + + + M + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Adenomatous | 2 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 2 2 1 2 1 1 1 2 1 2 2 1 1|
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | |
Interstitium, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Inflammation, Acute | 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Chronic | |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Fibrosis, Focal | |
Inflammation, Chronic | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Metaplasia, Osseous | |
Cortex, Cyst | 2 |
Renal Tubule, Regeneration | 2 |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 42
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2| 3 2.3|
Cytologic Alterations, Focal | X | 4 |
Fibrosis, Focal | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 | 8 1.1|
Necrosis, Focal | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | | 1 |
Fat, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
Acinus, Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 1 2 2 2 2 1 2 2 1 2 2 2 2 1 2| 38 1.5|
Artery, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Developmental Malformation | | 1 |
Inflammation, Acute | 2 1 | 3 1.7|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Capsule, Hyperplasia | 2 1 2 1 2 1 1 1 2 1 1 2 1 1 1 | 28 1.3|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
Hypertrophy, Focal | 2 | 5 1.8|
Hypertrophy | 2 1 1| 3 1.3|
Capsule, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M + + + + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 7 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + M + + + + + + + + + + + + + M M M| 41 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + + + M + + + + + + + + + + +| 44 |
Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
Tail, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Thalamus, Mineralization | 2 2 1 1 2 1 3 2 1 2 1 3 2 2 2 1 2 2 2 2| 43 1.7|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hyperplasia, Adenomatous | 1 | 3 1.3|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 1 1 1 1 2 2 2 2 2 2 1 1 1 1| 39 1.4|
Infiltration Cellular, Histiocyte | 1 3 3 | 4 2.3|
Pigmentation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 3 | 1 3.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 2 2.0|
Sinus, Inflammation, Acute | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cornea, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 1 1 2 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 | 34 1.2|
Metaplasia, Osseous | 2 | 1 2.0|
Cortex, Cyst | | 1 2.0|
Renal Tubule, Regeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + A + M M|
|__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 2 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 2 2 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Artery, Inflammation, Chronic | 2 2 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + |
Developmental Malformation | X X |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 1 1 1 2 1 2 1 2 2 1 1 1 2 1|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy, Focal | 1 |
Hypertrophy | 2 |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + M M M + M + + + + M + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + M + M + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + M + M + + + + + + + + M|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M + M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Subcutaneous Tissue, Abscess | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteomalacia | 2 |
Cranium, Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 1 |
Thalamus, Mineralization | 2 1 2 2 2 2 1 1 1 2 2 2 2 1 2|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Hyperplasia, Adenomatous | 2 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 |
Inflammation, Acute | 2 |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Hemorrhage | 3 |
Sinus, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
Inflammation, Chronic | 1 1 1 2 1 2 1 2 1 1 1 1 |
Metaplasia, Osseous | 2 |
Artery, Inflammation, Chronic | 2 |
Cortex, Necrosis, Focal | |
Pelvis, Dilatation | 2 |
Renal Tubule, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 53
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1|
Artery, Inflammation, Chronic | | 3 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + + | 5 |
Developmental Malformation | X X | 4 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 32 1.3|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 3 2.0|
Hypertrophy, Focal | 1 | 2 1.0|
Hypertrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 2 2 | 2 2.0|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X 2 1 | 6 1.8|
Inflammation, Chronic | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + M + + + +| 44 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + M| 44 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M M + M M M M M M M M| 4 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 2 1.0|
Subcutaneous Tissue, Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteomalacia | | 1 2.0|
Cranium, Hyperostosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Lymphocyte | | 1 1.0|
Thalamus, Mineralization | 1 1 1 2 1 1 1 2 1 1 1 2 2 1 2 1 2 1| 33 1.5|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.0|
Hyperplasia, Adenomatous | 1 2 | 3 1.7|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1 1 1 1 2 1 1 2 | 30 1.1|
Inflammation, Acute | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sinus, Hemorrhage | | 1 3.0|
Sinus, Inflammation, Acute | 2 | 1 2.0|
Turbinate, Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
20 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
LOW M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 2 1 2 | 25 1.2|
Metaplasia, Osseous | | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
Cortex, Necrosis, Focal | 2 | 1 2.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytologic Alterations, Focal | X X |
Inflammation, Acute | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Vacuolization Cytoplasmic | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Bacterium | 4 |
Atrium, Thrombosis | 4 |
Myocardium, Infarct | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Capsule, Hyperplasia | 1 3 1 2 1 1 2 2 2 2 2 1 1 2 1 1 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hypertrophy, Focal | 1 |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + M + + + + + M|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M + + + M M + M + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Acute | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + M + + M + M + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + M M + + + + M M M + + + + M|
Cyst | 2 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Tail, Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Choroid Plexus, Infiltration | |
Cellular, Lymphocyte | 1 |
Thalamus, Mineralization | 1 1 2 2 2 1 2 2 2 2 1 1 2 1 2 2 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 2 1 1 2 1 1 1 1 2|
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 1 1 1 1 2 2 1 1 1 1 1 2 1|
Papilla, Bacterium | 3 |
Papilla, Necrosis | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3| 1 3.0|
Cytologic Alterations, Focal | X | 3 |
Inflammation, Acute | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 1 2 2 | 15 1.3|
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Bacterium | | 1 4.0|
Atrium, Thrombosis | | 1 4.0|
Myocardium, Infarct | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1| 36 1.3|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy, Focal | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + M + + M + + + + + + + M| 41 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 | 7 1.6|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Inflammation, Acute | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 2 1.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + M + + + +| 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + + +| 41 |
Cyst | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M + M| 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
Tail, Epidermis, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Choroid Plexus, Infiltration | | |
Cellular, Lymphocyte | | 1 1.0|
Thalamus, Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 36 1.8|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 1 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05029-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
HIGH M/F | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 2 1 2 2 1 1 2 1 2 1| 33 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1|
Papilla, Bacterium | | 1 3.0|
Papilla, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
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