TR 387 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05029 DL AMPHETAMINE SULFATE TIME: 12:43:17
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55710
CONT: N01CP9565001 CAS: 60-13-9
PATHOLOGIST: W. HALL S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05029 DL AMPHETAMINE SULFATE TIME: 12:43:17
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55710
CONT: N01CP9565001 CAS: 60-13-9
PATHOLOGIST: W. HALL S. EUSTIS
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 48 |
| |
| UNCENSORED DEATHS |
| 36 383 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = LOW M/F20PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 1 CENSORED DEATHS 1 TERMINAL 48 |
| |
| UNCENSORED DEATHS |
| 695 |
| CENSORED DEATHS |
| 6 |
| |
|--------------------------------------------------------------------------------|
| DOSE = HIGH M/F100 PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 49 |
| |
| UNCENSORED DEATHS |
| 624 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 98.0 98.0 96.0 96.0 96.0 96.0 96.0 96.0 |
|CONTROL | |
| | |
|LOW | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 |
|M/F20PPM | |
| | |
|HIGH | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 |
|M/F100 PPM | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE LOW HIGH |
| CONTROL M/F20PPM M/F100 PPM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 96.0% 98.0% 98.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.986N P=1.000N P=0.986N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 209.5 695.0 624.0 |
|NATURAL DEATHS (C) | ( 174) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.2 713.9 726.9 |
|(STANDARD ERROR) | (15.4) (14.5) ( 2.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 732 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 519 527 534 579 603 632 632 671 681 686 |
| 687 699 711 711 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = LOW M/F20PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 495 497 511 613 634 643 646 654 690 700 |
| 701 704 704 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = HIGH M/F100 PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 253 253 555 687 708 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 732 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 732 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 86.0 70.0 |
|CONTROL | |
| | |
|LOW | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 94.0 84.0 72.0 |
|M/F20PPM | |
| | |
|HIGH | 100.0 100.0 96.0 96.0 96.0 96.0 96.0 94.0 94.0 88.0 |
|M/F100 PPM | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE LOW HIGH |
| CONTROL M/F20PPM M/F100 PPM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 72.0% 88.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.035N P=0.971N P=0.051N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 640.0 636.3 530.0 |
|NATURAL DEATHS (C) | (18.5) (21.3) (90.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.4 705.2 707.8 |
|(STANDARD ERROR) | ( 8.1) ( 8.5) (13.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DL AMPHETAMINE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
LOW M/F20PPM = 2
HIGH M/F100 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 1 3 2
|
|
|
99.5 +
|
|
|
P 99.0 +
E |
R |
C |
E 98.5 +
N |
T |
|
S 98.0 + 1 1 3 2 2
U |
R |
V |
I 97.5 +
V |
A |
L |
97.0 +
|
|
|
96.5 +
|
|
|
96.0 + 1 1
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
DL AMPHETAMINE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
LOW M/F20PPM = 2
HIGH M/F100 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
| 11
|
96 + 3 2 2 11 3
|
| 2 1 3 1 2 3
|
P 92 + 1 12 2 3 3
E |
R | 1 12 3 3
C |
E 88 + 22 3 3
N |
T | 1 22 1
|
S 84 + 2 1 12
U |
R | 22
V |
I 80 + 1122
V |
A | 11
L |
76 + 1 1
|
| 2 2
|
72 + 121 2
|
| 1 1
|
68 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
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