TR 387 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05029 DL AMPHETAMINE SULFATE TIME: 11:18:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55710
CONT: N01CP9565001 CAS: 60-13-9
PATHOLOGIST: R. KOVATCH
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05029 DL AMPHETAMINE SULFATE TIME: 11:18:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55710
CONT: N01CP9565001 CAS: 60-13-9
PATHOLOGIST: R. KOVATCH
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 316 512 533 558 579 625 634 637 638 659 |
| 664 676 684 684 691 695 708 717 722 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = LOW M/F20PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 236 384 415 437 467 524 576 585 655 660 |
| 666 667 674 682 688 694 695 705 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = HIGH M/F100 PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 436 436 498 582 607 621 627 639 659 660 |
| 666 675 695 703 711 722 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 90.0 78.0 60.0 |
|CONTROL | |
| | |
|LOW | 100.0 100.0 98.0 98.0 94.0 90.0 88.0 84.0 80.0 62.0 |
|M/F20PPM | |
| | |
|HIGH | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 92.0 80.0 66.0 |
|M/F100 PPM | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE LOW HIGH |
| CONTROL M/F20PPM M/F100 PPM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 62.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.623N P=1.000N P=0.680N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.9 585.9 627.2 |
|NATURAL DEATHS (C) | (21.7) (31.5) (22.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.6 674.6 694.4 |
|(STANDARD ERROR) | (10.9) (15.4) (10.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 478 485 541 547 593 655 660 666 667 677 |
| 677 694 701 710 719 719 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = LOW M/F20PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 340 578 590 624 632 666 669 706 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = HIGH M/F100 PPM |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 220 453 453 504 535 604 666 669 676 694 |
| 696 710 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DL AMPHETAMINE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 86.0 66.0 |
|CONTROL | |
| | |
|LOW | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 94.0 90.0 84.0 |
|M/F20PPM | |
| | |
|HIGH | 100.0 100.0 98.0 98.0 98.0 94.0 90.0 88.0 88.0 74.0 |
|M/F100 PPM | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE LOW HIGH |
| CONTROL M/F20PPM M/F100 PPM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 84.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.965N P=0.078N P=0.560N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 642.1 600.6 584.9 |
|NATURAL DEATHS (C) | (19.8) (40.1) (40.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.8 710.1 693.0 |
|(STANDARD ERROR) | ( 8.9) ( 9.1) (13.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DL AMPHETAMINE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
LOW M/F20PPM = 2
HIGH M/F100 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 1 2 1
|
96 + 2 2 3 3 1 1
|
| 2 2 3 1 1 3
|
92 + 2 2 1 13 3
|
| 2 2 1 3 31
|
P 88 + 2 2 311
E |
R | 22 3 3
C |
E 84 + 2 11 2 3
N |
T | 1 2 1
|
S 80 + 22
U |
R | 131
V |
I 76 + 211 3
V |
A | 22 33
L |
72 + 11 33
|
| 11 3 3
|
68 + 1 1
|
| 22113 3
|
64 + 2 11
|
| 2 2
|
60 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
DL AMPHETAMINE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
LOW M/F20PPM = 2
HIGH M/F100 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
| 3 2 3 11 2
| 1 1 2 2
95 +
| 3 3 11 2 2
P | 3 3 1 1 22
E |
R 90 + 3 1 3 2 1 2
C |
E | 3 1 13
N | 11 2
T 85 +
| 33 2 2
S | 11 3
U |
R 80 +
V |
I | 1 1 3
V | 113 3
A 75 +
L | 11 3 3
| 11
|
70 +
|
| 11
| 1 1
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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