TR 388 Mouse Pathology Tables
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + M + + + + + + A A + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A A + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Hyperplasia, Lymphoid | |
Infarct | 2|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 |
Necrosis | 1 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Active, Multifocal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Acute, Multiple | X |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 3 |
Hyperplasia | 2 |
Hypertrophy | 2 2 2|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +|
Pars Distalis, Hyperplasia | 2 3 3 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Follicle, Cyst | X X X X X X X X X X X X|
Periovarian Tissue, Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 3 2 2 3 3 2 3 3 3 3 3 2 3 3 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Sinus, Lymphatic, Ectasia | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Thoracic | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 4 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + + M M A A + M + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M M M + + + M + + + + M M M M + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 |
Parasite External | X X X X X |
Ulcer | 3 |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Hydrocephalus | |
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Acute | 3 |
Mediastinum, Hyperplasia, Lymphoid | |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 1 1 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Pelvis, Inflammation, Suppurative | 3 |
Renal Tubule, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + A + + A + + + + + + + + + A| 41 |
__________________________________________________________________________|____________|
Intestine Large | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + A + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 2 2 | 8 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infarct | 2 3 | 3 2.3|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.0|
Necrosis | 1 | 2 1.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 4 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 6 |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 | 2 4.0|
Duct, Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perivascular, Inflammation, Chronic | | |
Active, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dysplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Acute, Multiple | | 1 |
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 3 3 | 4 2.8|
Hyperplasia | | 1 2.0|
Hypertrophy | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 2 3 2 3 2 1 1 2 | 19 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 3 | 2 2.5|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 4.0|
Follicle, Cyst | X X X X | 16 |
Periovarian Tissue, Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | 3 | 2 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 2 3 2 3 3 2 2 3 2 3 3 3 3 2 3 2| 39 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumbar, Sinus, Lymphatic, Ectasia | 4 | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + +| 14 |
Hematopoietic Cell Proliferation | | 2 2.5|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Thoracic | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 5 3.0|
Hyperplasia, Lymphoid | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + M + M + + + + + + M +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M M M + M + + + + + + + + + + + + + + + + M| 35 |
Hyperplasia, Cystic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 5 2.0|
Parasite External | X | 6 |
Ulcer | | 1 3.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 2 |
Hemorrhage | 2 2 | 2 2.0|
Hydrocephalus | 2 3 | 2 2.5|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Interstitium, Inflammation, Acute | | 1 3.0|
Mediastinum, Hyperplasia, Lymphoid | 2 | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2 2 1 1 2 3 2 | 13 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Pelvis, Inflammation, Suppurative | | 1 3.0|
Renal Tubule, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A A M + A + + + |
__________________________________________________________________________|
Intestine Large | A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + |
__________________________________________________________________________|
Intestine Small | A A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 |
Infarct | 4 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | A A + + + + + + |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + |
__________________________________________________________________________|
Stomach | + A A + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + A A + + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperkeratosis, Focal | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | A A + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | A + A + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 3 3 2 2 2 1 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 2 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + |
Follicle, Cyst | X X X X X |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 3 3 2 2 3 3 3 3 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Femoral, Necrosis, Acute | 3 |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + |
Mandibular, Angiectasis | |
Mandibular, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | A + M + M + I M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Artery, Embolus | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 2 2 1 |
__________________________________________________________________________|
Nose | A + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | A + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Atrophy | |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + |
Glomerulus, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 13 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A A | 7 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 12 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 2 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Infarct | 3 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 13 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 15 |
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 13 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 1 1 2 2 2 2 2 2 2 | 19 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 2 2 | 8 1.6|
Follicular Cell, Vacuolization | | |
Cytoplasmic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 26 |
Follicle, Cyst | X X X | 8 |
Periovarian Tissue, Cyst | X X X X X| 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 33 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3| 28 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 13 |
Femoral, Necrosis, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 18 |
Mandibular, Angiectasis | 3 | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 23 |
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 13 |
__________________________________________________________________________|____________|
Skin | + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 13 |
Compression | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Artery, Embolus | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 5 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + | 12 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | 4 | 1 4.0|
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 12 |
Glomerulus, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Infarct | 3 |
Centrilobular, Cytomegaly | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Squamous | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Vacuolization | |
Cytoplasmic | 1 2 1 1 1 1 2 1 1 3 2 1 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Thrombosis | X |
Follicle, Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 3 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
__________________________________________________________________________|
Thymus | + M + M + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + |
Acanthosis | 2 2 2 2 |
Parasite External | X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
Tarsal, Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | X |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peribronchiolar, Inflammation, | |
Chronic Active | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Hemorrhage | 3 |
Nephropathy, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 8 |
__________________________________________________________________________|____________|
Gallbladder | + | 8 |
__________________________________________________________________________|____________|
Intestine Large | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 10 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + | 28 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 2 | 2 2.5|
Centrilobular, Cytomegaly | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 8 |
Acinus, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 8 |
__________________________________________________________________________|____________|
Stomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 10 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 8 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 28 |
Pars Distalis, Hyperplasia | 3 | 8 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 29 |
Follicular Cell, Vacuolization | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cytoplasmic | 2 2 | 19 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 20 |
Angiectasis | | 2 2.5|
Thrombosis | | 1 |
Follicle, Cyst | X | 8 |
__________________________________________________________________________|____________|
Uterus | + + | 13 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 | 7 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 8 |
Hematopoietic Cell Proliferation | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + | 13 |
__________________________________________________________________________|____________|
Thymus | M | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 8 |
__________________________________________________________________________|____________|
Skin | + | 8 |
Acanthosis | | 4 2.0|
Parasite External | | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 9 |
Tarsal, Hyperostosis | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 8 |
Compression | | 1 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 29 |
Peribronchiolar, Inflammation, | | |
Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + | 8 |
__________________________________________________________________________|____________|
Trachea | + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 8 |
Hemorrhage | | 1 3.0|
Nephropathy, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 2 |
Infarct | 3 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Mineralization, Multifocal| 2 |
Centrilobular, Cytomegaly | 2 2 2 2 2 1 2 2 |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
Oval Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + |
Acinus, Atrophy | 3 |
Acinus, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Acanthosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Subserosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Mineralization | 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 1 2 3 2 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 2 1 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 2 2 2 3 3 3 2 3 3 3 2 3 4 3 4 2 3 3 2 1 3 3 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Follicle, Cyst | X X X X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 3 3 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Angiectasis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peribronchiolar, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Nephropathy, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 8 |
__________________________________________________________________________|____________|
Gallbladder | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 3 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X X | 11 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 2 3 2 3 | 5 2.6|
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Mineralization, Multifocal| | 1 2.0|
Centrilobular, Cytomegaly | 2 2 2 | 11 1.9|
Centrilobular, Necrosis | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 3.0|
Oval Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + A | 7 |
Acinus, Atrophy | | 1 3.0|
Acinus, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 8 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 11 |
Acanthosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 8 |
Subserosa, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 8 |
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 8 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 1 3 2| 22 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 3 2 2 2 2 2 2 2 | 13 2.1|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 3 3 3 1 3 3 3 1 3 3 3 3 3 4 3 3 2 3 4 4 4 2 3| 49 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 15 |
Follicle, Cyst | X X | 6 |
Periovarian Tissue, Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 19 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 3 3 3 2 | 13 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 8 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 12 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 28 |
Hematopoietic Cell Proliferation | 3 3 3 2 | 6 2.8|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 9 |
Tarsal, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peribronchiolar, Inflammation, | | |
Chronic Active | 3 3 2 2 3 2| 7 2.4|
__________________________________________________________________________|____________|
Nose | + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Atrophy | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 11 |
Nephropathy, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 2 4 3 |
Infarct | 3 2 |
Inflammation, Chronic Active | 3 |
Centrilobular, Cytomegaly | 2 2 1 2 1 |
Centrilobular, Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + +|
Acinus, Atrophy | 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Diverticulum | 2 |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Bacterium, Acute, Multiple | |
Degeneration, Chronic | 4 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 2 2 3 2 2 4 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 3 2 2 2 2|
Follicular Cell, Vacuolization | |
Cytoplasmic | 3 3 2 2 4 3 2 3 3 2 3 3 3 3 2 4 2 3 3 3 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + +|
Follicle, Cyst | X X X X X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 4 |
Necrosis, Acute | |
__________________________________________________________________________|
Thymus | + + M + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + +|
Acanthosis | 2 2 2 |
Parasite External | X X X X X|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A M + A | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + A | 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 16 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + A | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Eosinophilic Focus | X X X | 4 |
Fatty Change, Focal | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 4 2.8|
Infarct | 3 3 3 4 | 6 3.0|
Inflammation, Chronic Active | | 1 3.0|
Centrilobular, Cytomegaly | 2 1 1 | 8 1.5|
Centrilobular, Necrosis, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A | 16 |
Acinus, Atrophy | | 1 3.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + | 17 |
Diverticulum | | 1 2.0|
Hyperplasia, Squamous | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 16 |
Bacterium, Acute, Multiple | 3 3 | 2 3.0|
Degeneration, Chronic | | 1 4.0|
Inflammation, Acute | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 16 |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 16 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 2 2| 23 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 2 1 2 2 1 2 2 3 2 | 17 2.0|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 3 3 3 3 2 3 3 3 3 3 2 3 3 3 2 2 4 2 3 4 2 4 3 2| 49 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 24 |
Follicle, Cyst | X X X X X X| 11 |
Periovarian Tissue, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 20 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 | 8 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Lymph Node | + A + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + | 14 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 31 |
Hematopoietic Cell Proliferation | 3 2 2 3 | 6 2.7|
Hyperplasia, Lymphoid | 2 | 3 2.7|
Necrosis, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M + M | 12 |
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 16 |
Acanthosis | 3 2 2 2 2 | 8 2.1|
Parasite External | X X X X X X | 11 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 16 |
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + A | 13 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + A M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X|
Hematopoietic Cell Proliferation | 2 3 |
Infarct | 3 3 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 1 |
Centrilobular, Cytomegaly | 2 2 1 1 1 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Acinus, Atrophy | 3 2 |
Duct, Ectasia | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Inflammation, Chronic | 2 |
Interstitium, Hyperplasia, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Hypertrophy | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + I + +|
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 2 2 2 3 2 2 3 2 2|
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 3 2 2 2 2 2 1 3 3 2 3 3 3 3 2 3 3 3 2 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + |
Hemorrhage | 4 |
Inflammation, Suppurative | 4 4 |
Follicle, Cyst | X X X X X X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + |
Angiectasis | 2 |
Dilatation | 3 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 3 3 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Femoral, Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Reticulum | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + M + M + M M |
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Parasite External | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Glomerulus, Inflammation, Acute | 3 |
Glomerulus, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 14 |
__________________________________________________________________________|____________|
Gallbladder | A A A A | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + A A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small | + A A + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + | 13 |
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X X X X X X X| 14 |
Hematopoietic Cell Proliferation | | 2 2.5|
Infarct | 3 | 4 2.8|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
Centrilobular, Cytomegaly | 2 2 2| 9 1.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A A + | 13 |
Acinus, Atrophy | | 2 2.5|
Duct, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + A | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 14 |
Inflammation, Chronic | | 1 2.0|
Interstitium, Hyperplasia, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | I + + A | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | I + + A | 11 |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + A | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A A + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 2 | 18 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 2 3 2 2 2 2 3 2 2 2 3| 22 2.2|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 3 2 2 1 3 3 3 3 3 2 3 3 2 3 2 3 1 3| 44 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + +| 25 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 2 4.0|
Follicle, Cyst | X X | 8 |
Periovarian Tissue, Cyst | X X| 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + A | 20 |
Angiectasis | 2 | 2 2.0|
Dilatation | | 2 2.5|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 3 | 9 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + | 13 |
Femoral, Hyperplasia, Neutrophil | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + A | 19 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Reticulum | | |
Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 9 |
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + M| 34 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 4 | 5 3.0|
Hyperplasia, Lymphoid | 2 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Thymus | M M M M | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + | 15 |
Parasite External | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2| 2 2.0|
__________________________________________________________________________|____________|
Nose | M + + + | 13 |
__________________________________________________________________________|____________|
Trachea | M + + A | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 15 |
Glomerulus, Inflammation, Acute | | 1 3.0|
Glomerulus, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A A A | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M + + + + + M + + A M + + + + + + + + M + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | 2 2 3 3 3 3 2 2 |
Mixed Cell Focus | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hematopoietic Cell Proliferation | 3 |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + + M + + M + M M M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 3 3 3 2 2 3 2 3 3 2 3 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 2 3 4 2 3 3 4 4 3 4 2 3 3 3 3 3 3 3 2 3|
Follicular Cell, Vacuolization | |
Cytoplasmic | 1 2 2 3 3 2 2 3 3 3 3 3 3 3 1 2 3 2 3 3 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Tubular | 2 |
Follicle, Cyst | X X X X X X |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + I + + + + + +|
Femoral, Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + M M + M M + M M M M + M + M M M M M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + M + M + M M + + M + + + + + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 2 2 2 2 2|
Parasite External | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Lip, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 4 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic Active | 4 |
Acinus, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + M + A + M + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Eosinophilic Focus | X | 3 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infarct | 2 3 3 2 3 | 13 2.5|
Mixed Cell Focus | X | 1 |
Centrilobular, Vacuolization | | |
Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 4.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 2.0|
Diverticulum | 2| 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Chronic | | 1 3.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + + M M M + + + M + + M + + M M + + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 2 2 2 3 3 2 2 3 3 3| 27 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 3 3 3 3 3 3 2 3 2 3 2 3 3 2 2 2 3 2 3 3 2 3 2 3 2| 46 2.8|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 3 3 2 3 3 3 3 3 3 3 3 3 2 2 3 2 3 3 3 3 3 3 3 3| 47 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Tubular | | 1 2.0|
Follicle, Cyst | X X | 8 |
Periovarian Tissue, Cyst | X | 2 |
Periovarian Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | 3 | 2 3.5|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 3 2 2 2 3 | 8 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + M + M + + + + + + + + + + A + + + + + + + + + +| 47 |
Mandibular, Hyperplasia, Lymphoid | | 4 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + M M + + + + + M + M + M M M + M + M M +| 23 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M + M M M + + + + M + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 3 2 2 1 2 2 2 2 2| 17 1.9|
Parasite External | X X X X X X X X X X X X| 22 |
Lip, Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 5 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 1 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Mucosa, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Inflammation, Chronic Active | | 1 4.0|
Acinus, Dilatation | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + A + + + + + A + + M + + + M M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3|
Infarct | 4 2 4 3 3 3 3 4 3 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Inflammation, Chronic Active | |
Centrilobular, Cytomegaly | 3 2 1 |
__________________________________________________________________________|
Mesentery | +|
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Ectasia | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Active, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M M M M + M M + + + + + M + + + M M M M +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 3 3 2 3 2 3 2 2 2 2 2 2 3 |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 4 3 3 3 3 2 1 3 3 3 2 3 3 2 2 3 3 3 3 4 3 3 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 2 2 3 2 2 2 4 3 3 3 2 3 3 2 3 3 2 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 4 |
Dilatation | 3 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 4 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 4|
Femoral, Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 2 |
Mandibular, Hyperplasia | |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M M I M + + + M + + M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + + + + M + + + + + M + M + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | X |
Parasite External | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 2 |
Perivascular, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Alveolar Epithelium, Hyperplasia | |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 1 1 1 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Nephropathy, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + M + + + + + + + M + + + + M + + M + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Infarct | 2 3 3 3 2 2 2 2 2 4 2 2 | 22 2.7|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2| 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Centrilobular, Cytomegaly | 1 2 3 1 3 | 8 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 | 1 4.0|
Duct, Ectasia | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perivascular, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + M M + M M + M M M + + + M + + + M + + +| 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 2 1 3 2 3 3 3 3 2 3 2 3 3| 28 2.5|
Pars Distalis, Vacuolization | | |
Cytoplasmic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 2 3 3 4 3 4 2 3 2 3 3 4 3 3 3 3 3 3 3 3 3 4 | 46 2.9|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 2 2 3 3 2 1 2 2 3 3 3 2 3 3 3 3 3 3 3 1 3 2 3| 48 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
Inflammation, Suppurative | | 1 3.0|
Follicle, Cyst | X X X X X | 7 |
Periovarian Tissue, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 2 3.0|
Dilatation | 2 3 2 | 5 2.4|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 2 2 2 2 2 2| 11 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Neutrophil | | 1 4.0|
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mandibular, Hyperplasia, Lymphoid | | 2 2.0|
Mandibular, Hyperplasia | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + M + + M + + M + M M + + + + M + M + M + +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M + + + M + + + M + + + + + + + M + + + +| 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 3 1 2 2 2 | 7 2.0|
Cyst Epithelial Inclusion | | 1 |
Parasite External | X X X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 |
Hydrocephalus | | 2 2.0|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 6 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.0|
Nephropathy, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + A + + M A M M + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + A + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + A + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | |
Eosinophilic Focus | X |
Fatty Change, Focal | 3 |
Hematopoietic Cell Proliferation | 2 |
Infarct | 2 3 3 3 3 3 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Mesentery | + + |
Angiectasis | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + A + + + + + + + + + + + + +|
Acinus, Atrophy | 4 1|
Acinus, Focal Cellular Change | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + +|
Incisor, Upper, Dysplasia | 1|
Peridontal Tissue, Infiltration | |
Cellular, Mast Cell | |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Acute, Multiple | 4 |
Mineralization | 1 |
Valve, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corticomedullary Junction, Cyst | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 |
Hypertrophy | 2 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + +|
Dilatation | 2 3|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hematopoietic Cell Proliferation | 3 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 1 3 2 |
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + + M + + M + M M M + + M + M M + + M M M + +|
Necrosis, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite External | |
Ulcer | |
Subcutaneous Tissue, Fibrosis | 2|
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | 1 2 1 2 2 2 2 3 3 2 1 1 3 2 3 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Metaplasia, Osseous | 1 |
Nephropathy, Chronic | 2 2 2 1 1 1 1 1 2 1 1 1 1 1 1|
Pelvis, Bacterium | 2 |
Pelvis, Inflammation, Suppurative | 1 2 |
Renal Tubule, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + + |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + I + + + + + + +|
Dilatation | 3 1 |
Inflammation, Chronic Active | 3 3 3 |
Mineralization | 3 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + A + + + + + + + + + + M + M + + + + + +| 40 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + A + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + M + A + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + A + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 3 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 2 |
Fatty Change, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Infarct | 3 3 3 3 3 3 2| 14 2.9|
Inflammation, Chronic Active | 2 2 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Angiectasis | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 2 2 1 | 5 2.0|
Acinus, Focal Cellular Change | X | 1 |
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Incisor, Upper, Dysplasia | 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Peridontal Tissue, Infiltration | | |
Cellular, Mast Cell | 3 | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Acute, Multiple | | 1 4.0|
Mineralization | | 1 1.0|
Valve, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corticomedullary Junction, Cyst | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 6 1.3|
Hypertrophy | 1 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + M + M + + + + I + + + + + M + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 4 |
Dilatation | | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 14 |
Hematopoietic Cell Proliferation | 3 2 2 2 1 3 2 2 2| 11 2.2|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | | 4 2.3|
Hematopoietic Cell Proliferation | 4 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + M + + + M I I + M + + + + + M| 29 |
Necrosis, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite External | X | 1 |
Ulcer | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X X| 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Peribronchiolar, Inflammation, | | |
Chronic Active | 3 1 2 2 1 1 3 1 2 | 26 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Acute | 3 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 4 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy, Chronic | 2 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 | 32 1.2|
Pelvis, Bacterium | | 1 2.0|
Pelvis, Inflammation, Suppurative | | 2 1.5|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 2 2.0|
Inflammation, Chronic Active | | 3 3.0|
Mineralization | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + M A A A A A A + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Infarct | 3 4 |
Inflammation, Chronic Active | |
Necrosis | |
Bile Duct, Cyst | X |
Centrilobular, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + M + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + |
Seminiferous Tubule, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + M + + + + + M + + + + M M M + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 |
Hyperplasia, Lymphoid | 2 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + M M + + + + + M M |
Depletion Lymphoid | |
Necrosis, Diffuse | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Acanthosis | 3 3 |
Parasite External | X X X |
Ulcer | 2 3 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
Tarsal, Hyperostosis | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Embolus | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + |
Hydronephrosis | |
Inflammation, Chronic Active | |
Nephropathy, Chronic | 1 2 2 |
Capsule, Fibrosis, Focal | 3 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | |
Bulbourethral Gland, Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + |
Calculus Gross Observation | |
Dilatation | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + A A + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + M + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + A + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + M + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A M + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + M + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + + A + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X | 5 |
Infarct | 3 3| 4 3.3|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 3 3 | 2 3.0|
Bile Duct, Cyst | X X | 3 |
Centrilobular, Cytomegaly | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + | 24 |
Acanthosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 23 |
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + M + + + + + + + + + + + + + + + + + +| 42 |
Pars Distalis, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Follicular Cell, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 22 |
Inflammation, Suppurative | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
Dilatation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 22 |
Seminiferous Tubule, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + | 21 |
Femoral, Hyperplasia, Neutrophil | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + M + + + + + + | 25 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 11 |
Hematopoietic Cell Proliferation | 2 2 2 | 7 2.6|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + | 25 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + M M M M | 11 |
Depletion Lymphoid | 3 | 1 3.0|
Necrosis, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + + +| 26 |
Acanthosis | 3 | 3 3.0|
Parasite External | X | 4 |
Ulcer | | 3 2.7|
Subcutaneous Tissue, Edema | 2| 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acute | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Femur, Hyperostosis | X | 1 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X| 24 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + A + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Artery, Embolus | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2 1 1 1 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 23 |
Hydronephrosis | 3 3 | 2 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Nephropathy, Chronic | | 3 1.7|
Capsule, Fibrosis, Focal | | 1 3.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
Bulbourethral Gland, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + | 20 |
Calculus Gross Observation | X X | 2 |
Dilatation | 4 3 | 3 3.7|
Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Infarct | 3 3 |
Centrilobular, Cytomegaly | 1 2 2 1 |
Centrilobular, Necrosis, Acute | 2 |
__________________________________________________________________________|
Pancreas | + + + + + A |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Degeneration, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | M M + + + + + + + + + I I + + + + + + + M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 1 2 1 1 2 2 2 1 2 2 2 2 2 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mandibular, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | M + M + + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + |
Acanthosis | 3 |
Alopecia | |
Hyperplasia, Basal Cell | |
Parasite External | X X |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Tarsal, Hyperostosis | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 1 |
Mediastinum, Inflammation | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 2 2 1|
__________________________________________________________________________|
Nose | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Capsule, Fibrosis, Focal | 2 |
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 8 |
__________________________________________________________________________|____________|
Gallbladder | A + | 6 |
__________________________________________________________________________|____________|
Intestine Large | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 7 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 7 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 33 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X | 1 |
Infarct | | 2 3.0|
Centrilobular, Cytomegaly | 2 1 | 6 1.5|
Centrilobular, Necrosis, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 8 |
__________________________________________________________________________|____________|
Stomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 7 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 8 |
Degeneration, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 8 |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 28 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 33 |
Follicular Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 1 2 2 2 2 2 | 25 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 8 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + | 8 |
__________________________________________________________________________|____________|
Testes | + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 15 |
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 7 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 12 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M M | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
Acanthosis | 2 3 2 | 4 2.5|
Alopecia | X | 1 |
Hyperplasia, Basal Cell | 4 | 1 4.0|
Parasite External | X X X X | 6 |
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Granuloma | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 25 |
Tarsal, Hyperostosis | X X X X X | 18 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 33 |
Alveolar Epithelium, Hyperplasia | 2 | 3 1.3|
Mediastinum, Inflammation | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 5 1.8|
__________________________________________________________________________|____________|
Nose | + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 11 |
Capsule, Fibrosis, Focal | | 1 2.0|
Cortex, Cyst | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 8 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + + |
__________________________________________________________________________|
Gallbladder | M A A + + + A A + + A |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + A |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 4 |
Infarct | 3 |
Inflammation, Chronic Active | |
Bile Duct, Hyperplasia | |
Central Vein, Thrombosis | |
Centrilobular, Cytomegaly | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2|
Centrilobular, Necrosis, Acute | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + A |
Acinus, Inflammation, Chronic Active | 3 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + A + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + A |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + A |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + A |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + M + + + M M + + + + + + + + +|
Ectasia | 3 |
Craniopharyngeal Duct, Inflammation, | |
Chronic Active | 3 |
Pars Distalis, Cyst | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Follicular Cell, Vacuolization | |
Cytoplasmic | 3 3 3 3 3 3 2 3 3 2 3 3 3 3 2 2 3 3 2 3 3 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | 3 3 |
Duct, Dilatation | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + A + + + |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
Seminiferous Tubule, Degeneration | 2 3 |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + |
Femoral, Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + |
Mandibular, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + A |
Hematopoietic Cell Proliferation | 2 2 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M M + + M M M M + + + |
Depletion Lymphoid | 3 |
Necrosis, Diffuse | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Acanthosis | 2 3 |
Parasite External | X X X X |
Ulcer | 2 2 |
Prepuce, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Subcutaneous Tissue, | |
Foreign Body | 4 |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Sebaceous Gland,| |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Peribronchiolar, Inflammation, | |
Chronic Active | 3 1 4 2 2 2 1 1 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Nephropathy, Chronic | 1 1 |
Pelvis, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + A |
Dilatation | 3 3 |
Inflammation, Chronic Active | 3 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Gallbladder | A + M + + A + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 17 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 5 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X X | 8 |
Hematopoietic Cell Proliferation | | 1 4.0|
Infarct | 3 4 2 3 4 3 | 7 3.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 2 | 2 2.0|
Central Vein, Thrombosis | X | 1 |
Centrilobular, Cytomegaly | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 36 2.0|
Centrilobular, Necrosis, Acute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 17 |
Acinus, Inflammation, Chronic Active | | 1 3.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M M I + M + + + +| 42 |
Ectasia | | 1 3.0|
Craniopharyngeal Duct, Inflammation, | | |
Chronic Active | | 1 3.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 3 2 3 3 3 3 3 2 2 3 2 2 2 2 3 3 3 3 3 2 3 3| 46 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 18 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Inflammation, Chronic Active | | 2 3.0|
Duct, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 18 |
Inflammation, Chronic Active | 1 | 2 2.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 20 |
Seminiferous Tubule, Degeneration | | 2 2.5|
Seminiferous Tubule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 18 |
Femoral, Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 22 |
Mandibular, Hyperplasia, Lymphoid | 2 3| 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 4 |
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 21 |
Hematopoietic Cell Proliferation | | 4 2.5|
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 3.0|
Necrosis, Diffuse | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 23 |
Acanthosis | 3 3 | 4 2.8|
Parasite External | X | 5 |
Ulcer | 2 | 3 2.0|
Prepuce, Inflammation, Acute | | 1 3.0|
Prepuce, Subcutaneous Tissue, | | |
Foreign Body | | 1 4.0|
Subcutaneous Tissue, Fibrosis | 2 | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Subcutaneous Tissue, Sebaceous Gland,| | |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 42 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X X X X | 28 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 3 | 2 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2 1 2 2 2 2 3| 17 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + +| 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 21 |
Nephropathy, Chronic | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 17 |
Dilatation | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M M + M + + + + |
__________________________________________________________________________|
Gallbladder | + + M M + M + A A + |
__________________________________________________________________________|
Intestine Large | + + + + + M + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + M M + M + + A + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + M + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + M + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + M + M + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + M M + M + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + M M + M + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A M + M + + + + |
__________________________________________________________________________|
Liver | + + + + + + M M + M + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 |
Infarct | 4 |
Centrilobular, Cytomegaly | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + M M + M + + + + |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + M M + M + + + + |
__________________________________________________________________________|
Stomach | + + M M + M + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + M M + M + + + + |
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M M + M + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + M M + M + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M M + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + M M + M + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + + M M + M I + + + M + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M M + M + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 3 |
Follicular Cell, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic | 2 2 3 2 1 2 2 2 2 3 3 2 2 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M M + M + + + + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + M M + M + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
__________________________________________________________________________|
Testes | + + M M M + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + I + I + A + |
__________________________________________________________________________|
Lymph Node | + + M M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Hematopoietic Cell Proliferation | 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + M M + M + + + + + + + + + |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 4 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + M M + M + + M M |
Depletion Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M |
__________________________________________________________________________|
Skin | + + M M + M + + + + + + + + + + |
Acanthosis | 3 2 2 |
Parasite External | X X X X |
Ulcer | 2 |
Subcutaneous Tissue, Fibrosis | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Metaplasia, | |
Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + I + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Tarsal, Hyperostosis | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + M M + M + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Hyperplasia, Macrophage | |
Peribronchial, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 2 2 2 1 1 1 3 2 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + M + + M + + + + |
__________________________________________________________________________|
Trachea | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + M M + M + + + + + |
Cortex, Cyst | X |
Cortex, Infiltration Cellular, Focal,| |
Histiocyte | |
__________________________________________________________________________|
Urinary Bladder | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + +| 14 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + +| 15 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Basophilic Focus | X X | 4 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 3 |
Hematopoietic Cell Proliferation | 2 3 | 3 2.3|
Infarct | 2 4 | 3 3.3|
Centrilobular, Cytomegaly | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1| 33 1.9|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 15 |
Inflammation, Chronic Active | 2 | 1 2.0|
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + +| 16 |
Acanthosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + +| 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I I + + + + + + + + + + + + + + I + + + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Follicular Cell, Hyperplasia | | 3 2.3|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 3 2 2 2 3 2 3 3 3 3 3 3 3 3 3 3 3 2 3 2 3 3 1 3| 43 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Inflammation, Chronic Active | 3 3 | 2 3.0|
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + +| 15 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + +| 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + I| 13 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + | 8 |
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 24 |
Depletion Lymphoid | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 3 | 5 3.2|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M| 11 |
Depletion Lymphoid | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + +| 25 |
Acanthosis | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Parasite External | | 4 |
Ulcer | 3 3 2 3| 5 2.6|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 2 3.0|
Subcutaneous Tissue, Metaplasia, | | |
Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + I + + + + + + + + + + + +| 39 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X X X X| 29 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic, Diffuse | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 | 5 1.2|
Alveolus, Hyperplasia, Macrophage | 3 | 1 3.0|
Peribronchial, Inflammation, Chronic | | |
Active | 1 1 | 2 1.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 1 1 2 2 2 | 16 1.7|
Perivascular, Inflammation, Chronic | | |
Active | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + +| 17 |
Cortex, Cyst | | 1 |
Cortex, Infiltration Cellular, Focal,| | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M M A + + A|
__________________________________________________________________________|
Intestine Large | + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 |
Infarct | 2|
Mixed Cell Focus | |
Bile Duct, Cyst | |
Central Vein, Thrombosis | |
Centrilobular, Cytomegaly | 2 1 2 2 1 2 2 2 2 2 3 2 1 2 2 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Acinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + I|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + I|
Hyperplasia | 3 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + I|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
Follicular Cell, Hyperplasia | 2 2 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 3 3 2 3 3 2 2 3 3 2 3 3 3 3 3 1 2 3 2 2 3 3 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M|
Mandibular, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + |
Hemorrhage | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 4|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + + + + M|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + +|
Acanthosis | 2 |
Parasite External | X X |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Hyperplasia, Macrophage | |
Peribronchial, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, | |
Chronic Active | 1 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + A|
Mucosa, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Nephropathy, Chronic | 1 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + A + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Gallbladder | A + + A + + + + + A +| 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + +| 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A + + + + A A +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + M + +| 16 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + A + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + A A +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A A +| 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + +| 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | X | 5 |
Eosinophilic Focus | | 3 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2| 4 3.0|
Infarct | 4 | 2 3.0|
Mixed Cell Focus | X X | 2 |
Bile Duct, Cyst | X X | 2 |
Central Vein, Thrombosis | X | 1 |
Centrilobular, Cytomegaly | 2 3 2 2 2 2 1 2 2 2 2 2 2| 29 1.9|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + A + +| 17 |
Acinus, Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M M + + + + +| 17 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + +| 22 |
Acanthosis | 3 | 1 3.0|
Cyst Epithelial Inclusion | X | 1 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + +| 18 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + +| 18 |
Hyperplasia | | 1 3.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + A + +| 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + +| 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 2 2 2 2 2 | 7 2.0|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 3 1 3 3 3 3 2 3 2 2 3 3 3 2 3 3 1 2 2 1 3| 46 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + +| 19 |
Inflammation, Chronic Active | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
Inflammation, Chronic Active | 4 | 2 3.5|
Duct, Dilatation | | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + +| 19 |
Inflammation, Chronic Active | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + +| 19 |
Femoral, Hyperplasia, Neutrophil | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + +| 22 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 6 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 4 3 4 3| 8 3.4|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M + A + M + + M M +| 11 |
Depletion Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Acanthosis | 2 | 2 2.0|
Parasite External | X X X | 5 |
Ulcer | 2 | 3 2.3|
Subcutaneous Tissue, Fibrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 38 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X X X X X X X | 29 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 1| 3 1.7|
Alveolus, Hyperplasia, Macrophage | 4 | 1 4.0|
Peribronchial, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2 2 1 1 2 | 7 1.4|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + +| 18 |
Mucosa, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + +| 19 |
Nephropathy, Chronic | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + +| 16 |
Dilatation | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M M + + + A + A + + + + M + + M + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + A + A + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + A + + + + + + M|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + A + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + A + + + + + + M|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 |
Infarct | 2 4 3 1 2 2 3 2 2 2 1 2 2 2 3|
Centrilobular, Cytomegaly | 1 2 1 1 2 2 1 1 2 2 1 1 2 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Angiectasis | 2 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + A + + + + + + +|
Acinus, Atrophy | 4 4 1 |
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Perivascular, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Dysplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
Incisor, Upper, Dysplasia | |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Acute, Multiple | |
Artery, Inflammation, Chronic Active | 2 |
Valve, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Hypertrophy | 2 2 1 1 1 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M + + + M M + M M M M M + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + I + + + I + I + + + + + + M + +|
Pars Distalis, Hyperplasia | 3 3 2 3 2 3 2 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 3 3 3 2 4 2 2 3 2 4 3 3 3 4 3 3 3 1 3 |
Follicular Cell, Vacuolization | |
Cytoplasmic | 2 4 3 3 3 2 3 4 3 4 2 3 3 4 3 2 4 3 4 3 3 4 3 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + M + + + + + + + +|
Arteriole, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Arteriole, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | |
Active | 1 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | M M + M + + M + + M + M + M M + M + M M M + M + M|
Necrosis, Diffuse | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite External | X X X X X X X X X X X X X X|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 3 |
Alveolar Epithelium, Hyperplasia | 2 3 |
Alveolus, Hyperplasia, Macrophage | |
Arteriole, Capillary, Inflammation, | |
Suppurative | |
Artery, Mediastinum, Inflammation, | |
Suppurative | |
Peribronchiolar, Inflammation, Acute,| |
Necrotizing | 4 |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 2 2 1 1 2 3 1 1|
Perivascular, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 2 |
Inflammation | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + |
Inflammation, Chronic Active | 4 2 4 4 3 |
Inflammation, Suppurative | 4 2 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urethra | + + + |
Inflammation, Suppurative | 3 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Arteriole, Inflammation, Chronic | |
Active | 1 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A M M + + + + + + A M + M + A + + + + A M + M + +| 33 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A A + + + A + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
Parasite Metazoan | X X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + A A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A A + + + A + + + + + + + + + +| 43 |
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A + + + + + + + + + +| 44 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | 3 2 1 2 3 4 4 2 3 3 4 1 3 3 3 1 2 4 | 33 2.5|
Centrilobular, Cytomegaly | 1 2 2 2 1 1 1 2 1 1 | 25 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Angiectasis | | 1 2.0|
Inflammation, Acute, Necrotizing | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A A + + + A + + + + + + + + + +| 45 |
Acinus, Atrophy | 1 | 4 2.5|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 1 2.0|
Perivascular, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Dysplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + +| 4 |
Incisor, Upper, Dysplasia | 1 | 1 1.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | 2| 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Acute, Multiple | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Valve, Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.7|
Hypertrophy | 2 3 1| 10 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A A + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + M + + + + + + M + + + + + + M + M +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A M + + + + + + + + M M + + + +| 41 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2| 32 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 3 2 2 3 1 2 2 2 2 2 3 2 2 3 2 2 2 2 2 4 3 3 2 2| 44 2.5|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 3 2 3 3 3 4 3 4 3 3 4 3 3 2 3 4 4 4 3 2 3 3 4| 47 3.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arteriole, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | | 1 1.0|
Arteriole, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | | |
Active | | 1 1.0|
Seminiferous Tubule, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 7 |
Hematopoietic Cell Proliferation | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | M M M + M M + M I M + M I M M M I M M M + + M M M| 16 |
Necrosis, Diffuse | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Parasite External | X X X X X X X X X X X X X X| 28 |
Subcutaneous Tissue, Edema | 4 | 1 4.0|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | X X X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Alveolus, Hyperplasia, Macrophage | 2 | 1 2.0|
Arteriole, Capillary, Inflammation, | | |
Suppurative | 4 | 1 4.0|
Artery, Mediastinum, Inflammation, | | |
Suppurative | 4 | 1 4.0|
Peribronchiolar, Inflammation, Acute,| | |
Necrotizing | | 1 4.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 2 2 1 1 1 2 2 3 2 2 3 1| 21 1.8|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Atrophy | 4 4 2 | 5 3.2|
Inflammation | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + | 18 |
Inflammation, Chronic Active | 4 4 3 1 1 | 10 3.0|
Inflammation, Suppurative | 3 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 1 1 1 1 2 2 2 1 1| 22 1.2|
Pelvis, Inflammation, Suppurative | | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 3 |
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 3.0|
Arteriole, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + A A + + M M M M M + + A + M M + M A M +|
Epithelium, Hypertrophy, Focal | 2|
__________________________________________________________________________|
Intestine Large | + A + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A A + + + + + + A + + A + A + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + A A + + + M + + + + + A + A + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + A + + + A + + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A M + + + + M + A + + A + A + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A A + + + + + + A + + A + A + + + A + +|
Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X X|
Infarct | 2 3 3 3 3 3 3 2 2 3 2 4 4 2 |
Centrilobular, Cytomegaly | 3 3 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
Oval Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + A + +|
Acinus, Atrophy | 2|
Duct, Ectasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | + A + + + A + + + + + + + + + + + + + + + A + +|
Infiltration Cellular, Mast Cell | 2|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 3 |
Mineralization | 2 |
Thrombosis | X |
Valve, Bacterium | 3 |
Valve, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Hypertrophy | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + A + + M + M + + M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + I + M + A + M M + + + + + + + + + M + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 1 2 2 3 1 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 4 3 3 2 4 3 2 2 4 3 3 3 1 3 2 3 2 2 4 4 2|
Follicular Cell, Vacuolization | |
Cytoplasmic | 3 2 2 2 2 2 3 3 2 3 2 2 2 3 3 3 3 2 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + A + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + A + + + + + + + + + M + + + + + + + + +|
Lumbar, Necrosis | 3 |
Pancreatic, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + A + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + M + M A M M M M + + M M M M M M M + M M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Parasite External | X X |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + A + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 3 |
Peribronchiolar, Inflammation, | |
Chronic Active | 1 1 2 3 3 2 1 |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + |
Inflammation, Chronic Active | 3 2 |
Inflammation, Suppurative | 4 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy, Chronic | 1 1 1 1 2 1 1 1 1 1|
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + M M A M M + + + + A + M + M| 27 |
Epithelium, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A A + + + + + + + + A + +| 40 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 |
Parasite Metazoan | X X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +| 41 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A A + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + A A + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + + + + + +| 40 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A + + + + + + A + + + +| 40 |
Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X | 11 |
Infarct | 1 2 2 2 3 3 2 2 2 2 2 2 2 3 1 4 1 3 2 2| 34 2.4|
Centrilobular, Cytomegaly | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1| 40 2.0|
Oval Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Acinus, Atrophy | 2 | 2 2.0|
Duct, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Thrombosis | | 1 |
Valve, Bacterium | | 1 3.0|
Valve, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1| 3 1.0|
Hypertrophy | 2 1 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + M M + + + + + + M + + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + M + + + + + M + + I + + + M + + + + + + +| 39 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 | 25 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 3 2 2 2 4 3 4 4 4 3 3 3 1 3 4 3 3 3 3 1 2 3 3 3| 47 2.8|
Follicular Cell, Vacuolization | | |
Cytoplasmic | 2 2 3 3 2 2 1 3 2 2 3 4 3 3 1 2 2 2 2 4 3 3 1| 46 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 2| 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lumbar, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + +| 5 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + I M M M M M M I M A M M M + + + + + I + M| 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 | 1 1.0|
Parasite External | X X X X | 6 |
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | X X X X X X X X X X X X X X X | 24 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 2 2 | 4 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | 1 2 3 2 3 2 2 2 2 1 2 | 18 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 6 |
Inflammation, Chronic Active | | 2 2.5|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05076-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 18:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 1 2.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 | 17 1.1|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
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