TR 388 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05076 ETHYLENETHIOUREA TIME: 02:18:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 03372
CONT: N01ES82151 CAS: 96-45-7
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05076 ETHYLENETHIOUREA TIME: 02:18:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 03372
CONT: N01ES82151 CAS: 96-45-7
PATHOLOGIST: R. PERSING S. EUSTIS
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 20 178 184 281 283 302 311 427 520 565 |
| 566 618 630 656 662 666 666 672 705 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 6 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 180 234 235 279 307 309 351 351 351 368 |
| 578 628 663 711 716 722 735 |
| CENSORED DEATHS |
| 51 51 51 51 51 171 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM 1-1 |
| ---------------------------- |
| |
| TOTAL 34 UNCENSORED DEATHS 7 CENSORED DEATHS 1 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 345 424 516 532 557 593 705 |
| CENSORED DEATHS |
| 641 |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 333 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 95 142 241 602 619 622 623 627 662 677 |
| 690 690 695 704 718 729 734 740 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 333 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 8 13 14 25 124 311 526 584 595 649 |
| 651 666 676 677 681 690 704 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 333 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 395 532 535 536 562 573 576 613 658 663 |
| 669 674 693 705 707 724 728 740 |
| CENSORED DEATHS |
| 311 |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 3 199 226 241 525 576 582 618 636 636 |
| 650 669 671 671 672 672 688 689 690 694 |
| 694 700 710 715 723 726 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 260 295 297 449 507 522 529 557 597 641 |
| 658 663 669 685 685 685 693 694 697 697 |
| 701 718 727 727 737 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 743 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 743 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 98.0 96.0 94.0 86.0 86.0 84.0 82.0 78.0 70.0 62.0 |
| | |
| | |
|0 | 100.0 97.7 93.2 79.5 77.3 77.3 77.3 75.0 70.5 61.4 |
|PPM 10-0 | |
| | |
|100 | 100.0 100.0 100.0 97.1 94.1 94.1 88.2 82.4 82.4 79.3 |
|PPM 1-1 | |
| | |
|333 | 100.0 96.0 94.0 94.0 94.0 94.0 94.0 92.0 82.0 64.0 |
|PPM 0-3 | |
| | |
|333 | 92.0 90.0 90.0 88.0 88.0 88.0 86.0 82.0 78.0 64.0 |
|PPM 3-3 | |
| | |
|333 | 100.0 100.0 100.0 100.0 98.0 98.0 91.8 85.7 79.6 63.3 |
|PPM 10-3 | |
| | |
|1000 | 98.0 98.0 92.0 92.0 92.0 92.0 90.0 86.0 78.0 46.0 |
|PPM 0-10 | |
| | |
|1000 | 100.0 100.0 98.0 94.0 94.0 92.0 86.0 82.0 76.0 50.0 |
|PPM 10-10| |
| | |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 743 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 100 333 333 333 1000 1000 |
| PPM 10-0 PPM 1-1 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 61.4% 79.3% 64.0% 64.0% 63.3% 46.0% 50.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.022 ----- P=0.148N P=0.726N P=0.894N P=0.757N P=0.353 P=0.553 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 469.1 454.0 524.6 589.4 461.4 626.8 592.7 603.6 |
|NATURAL DEATHS (C) | (48.6) (49.2) (43.9) (48.1) (67.6) (21.8) (36.7) (28.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 638.9 564.1 695.0 687.7 641.6 692.5 661.8 673.3 |
|(STANDARD ERROR) | (26.3) (36.1) (17.6) (20.0) (30.7) (13.5) (22.4) (17.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 327 411 487 499 499 624 648 665 667 667 |
| 670 698 701 705 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 491 523 540 555 587 609 611 642 698 712 |
| 725 737 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM 1-1 |
| ---------------------------- |
| |
| TOTAL 29 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 359 529 552 562 612 655 668 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 333 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 503 529 569 667 667 668 674 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 333 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 605 621 647 648 648 660 663 677 680 688 |
| 688 698 706 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 333 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 440 619 625 650 653 653 665 698 701 710 |
| 734 738 738 738 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 13 499 539 611 614 619 653 657 663 663 |
| 674 691 691 691 697 698 726 733 735 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 275 443 457 542 570 579 598 640 642 663 |
| 677 678 680 683 697 697 701 709 709 712 |
| 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 740 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 100.0 98.0 96.0 96.0 90.0 90.0 84.0 70.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 84.0 76.0 |
|PPM 10-0 | |
| | |
|100 | 100.0 100.0 100.0 96.6 96.6 96.6 93.1 86.2 79.3 72.4 |
|PPM 1-1 | |
| | |
|333 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 94.0 86.0 |
|PPM 0-3 | |
| | |
|333 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 86.0 72.0 |
|PPM 3-3 | |
| | |
|333 | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 86.0 72.0 |
|PPM 10-3 | |
| | |
|1000 | 98.0 98.0 98.0 98.0 98.0 98.0 94.0 94.0 80.0 62.0 |
|PPM 0-10 | |
| | |
|1000 | 100.0 100.0 100.0 98.0 98.0 94.0 92.0 86.0 80.0 58.0 |
|PPM 10-10| |
| | |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 740 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 100 333 333 333 1000 1000 |
| PPM 10-0 PPM 1-1 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 76.0% 72.4% 86.0% 72.0% 72.0% 62.0% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.026 ----- P=1.000N P=0.087N P=0.904N P=0.849N P=0.566 P=0.327 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.8 619.2 580.3 611.0 667.0 668.7 624.6 623.1 |
|NATURAL DEATHS (C) | (31.5) (24.3) (38.4) (28.3) ( 8.3) (20.9) (36.8) (24.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 697.6 711.0 695.9 721.9 719.6 720.0 696.1 690.9 |
|(STANDARD ERROR) | (13.1) ( 9.3) (16.8) ( 7.4) ( 5.2) ( 7.3) (15.9) (13.2) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLENETHIOUREA
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
100 PPM 1-1 = 3
333 PPM 0-3 = 4
333 PPM 3-3 = 5
333 PPM 10-3 = 6
1000 PPM 0-10 = 7
1000 PPM 10-10 = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1751 4 2 8 3 6
| 7 1 4 4 1 7 2 8 8 3 6 3 6
| 5 5 4 11 7 7 4 1 8 3 8 3 66 4
| 5 5 27 2 8 8 7 6 6 4 4
P 90 + 5 21 15 8373 667
E | 11 2 83 3 667
R | 1 1 15 3 6538 6447 4
C | 1 1 38 6 8564 4 3
E 80 + 2 2 7878664 4 3 3
N | 2 1 2 1 58856
T | 2 11 18558444
| 2 11 556 4 4
S 70 + 11 55 62464
U | 7 85 522
R | 1 881522444
V | 771 2261
I 60 + 88
V | 8 8
A | 7 778
L | 77 8
50 + 88
|
| 7 7
|
40 +
|
---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 61 obs hidden.
ETHYLENETHIOUREA
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
100 PPM 1-1 = 3
333 PPM 0-3 = 4
333 PPM 3-3 = 5
333 PPM 10-3 = 6
1000 PPM 0-10 = 7
1000 PPM 10-10 = 8
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 7 8 1 3 6 24 5
|
| 7 8 1 1 68 24 24 5 5
| 3 1 8 8 1 7 2372 4 56 5
95 +
| 8 1 1 72 2 4 7 6 6 4
| 3 832 8 2 66
|
90 + 1 3 3882 2771 5 5
|
P | 8 82271 16 644
E | 3 8 2 21 1 4 6 4
R 85 +
C | 2 7 1155 26
E | 3 8 3 8 55262
N |
T 80 + 7 7 2 2 6
| 3 3
S | 17 51 2 62
U | 388 11 2
R 75 +
V | 55
I | 87711 3
V |
A 70 + 1 1
L |
| 78 7
| 88 7 7
65 +
|
| 77
|
60 + 8 8
|
| 88
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 36 obs hidden.
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