TR 388 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ETHYLENETHIOUREA
NTP Experiment-Test: 05076-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 20 15 13 8 10 13
Natural Death 6 5 3 9 13 4
Survivors
Moribund Sacrifice 2 1
Terminal Sacrifice 23 30 34 30 26 32
Natural Death 1 1 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (50) (49) (50)
Intestine Large, Colon (47) (47) (50) (45) (43) (47)
Intestine Small, Duodenum (49) (49) (50) (48) (48) (49)
Intestine Small, Ileum (45) (47) (48) (42) (42) (44)
Jejunum, Sarcoma Stromal, Metastatic 1 (2%)
Intestine Small, Jejunum (47) (47) (50) (44) (45) (48)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (3) (2) (2) (1) (4) (8)
Adenocarcinoma, Metastatic, Uterus 1 (33%)
Sarcoma Stromal, Metastatic, Uterus 1 (50%)
Pancreas (50) (49) (50) (49) (49) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Salivary Glands (50) (50) (50) (50) (50) (49)
Stomach, Forestomach (49) (49) (50) (49) (48) (50)
Glandular, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Stomach, Glandular (48) (49) (50) (48) (48) (50)
Tongue (1) (1) (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (49) (48) (49) (50)
Adenoma 2 (4%) 1 (2%) 6 (12%) 2 (4%)
Capsule, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Adrenal Gland, Medulla (50) (49) (49) (49) (49) (50)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Benign 2 (4%) 8 (16%) 1 (2%) 1 (2%) 5 (10%) 7 (14%)
Bilateral, Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Islets, Pancreatic (50) (49) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (46) (47) (48) (46) (46) (47)
Adenoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (49) (49) (49) (49)
Pars Distalis, Adenoma 24 (48%) 23 (46%) 26 (53%) 25 (51%) 20 (41%) 25 (51%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (48) (49) (44) (46) (47)
Bilateral, C-Cell, Adenoma 3 (6%) 2 (4%)
Bilateral, Follicular Cell, Adenoma, Multiple 1 (2%)
C-Cell, Adenoma 11 (22%) 10 (21%) 14 (29%) 12 (27%) 6 (13%) 6 (13%)
C-Cell, Carcinoma 1 (2%) 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Adenocarcinoma 2 (4%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 5 (11%) 5 (11%) 7 (15%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (50) (49) (47) (49) (45)
Adenoma 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Cystadenoma 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (50) (50) (50) (50) (50) (50)
Adenocarcinoma 1 (2%)
Page 3
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyoma 1 (2%) 1 (2%) 1 (2%)
Polyp Stromal 8 (16%) 6 (12%) 13 (26%) 15 (30%) 7 (14%) 6 (12%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%) 1 (2%)
Cervix, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (10) (10) (16) (14) (18) (11)
Bone Marrow (50) (50) (49) (50) (47) (50)
Lymph Node (50) (49) (50) (50) (50) (50)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (5) (8) (6) (14) (14) (6)
Spleen (50) (50) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Fibrosarcoma 2 (4%)
Hemangiosarcoma 1 (2%)
Thymus (43) (46) (44) (44) (45) (42)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (47) (50) (50) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%) 2 (4%)
Adenoma 1 (2%) 1 (2%) 2 (4%)
Fibroadenoma 10 (20%) 11 (23%) 7 (14%) 11 (22%) 11 (22%) 9 (18%)
Fibroadenoma, Multiple 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Mixed Tumor Malignant 1 (2%)
Skin (50) (49) (50) (50) (50) (48)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lip, Osteosarcoma,
Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50) (50) (50)
Chondrosarcoma 2 (4%)
Mandible, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Page 4
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Diaphragm, Sarcoma Stromal, Metastatic,
Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Meningioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mixed Tumor Malignant, Metastatic, Mammary
Gland 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Nose (50) (50) (49) (50) (49) (50)
Trachea (50) (50) (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Fibrosarcoma 1 (100%)
Harderian Gland (50) (50) (50) (50) (50) (50)
Zymbal's Gland (1) (3)
Adenoma 2 (67%)
Carcinoma 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Lipoma 1 (2%)
Mixed Tumor Benign 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (49) (48) (50) (47) (48) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Page 5
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Hemangioma 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 18 (36%) 18 (36%) 19 (38%) 22 (44%) 29 (58%) 23 (46%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 46 46 46 46 47
Total Primary Neoplasms 95 95 107 112 102 109
Total Animals with Benign Neoplasms 40 38 39 39 40 38
Total Benign Neoplasms 68 69 80 81 65 74
Total Animals with Malignant Neoplasms 25 23 24 28 35 30
Total Malignant Neoplasms 27 26 27 31 37 35
Total Animals with Metastatic Neoplasms 3 2 1 2 1 2
Total Metastatic Neoplasm 12 5 1 2 1 2
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 26 30
Natural Death 4 6
Survivors
Terminal Sacrifice 20 13
Natural Death 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (45) (49)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (45) (50)
Liver (50) (50)
Hepatocellular Carcinoma 1 (2%)
Pancreas (49) (50)
Salivary Glands (50) (50)
Stomach, Forestomach (50) (50)
Stomach, Glandular (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (50) (50)
Pheochromocytoma Benign 6 (12%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Pituitary Gland (50) (50)
Pars Distalis, Adenoma 18 (36%) 24 (48%)
Pars Distalis, Carcinoma 3 (6%) 2 (4%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 2 (4%)
Page 8
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Follicular Cell, Adenocarcinoma 1 (2%) 4 (8%)
Bilateral, Follicular Cell, Adenoma 6 (12%) 9 (18%)
Bilateral, Follicular Cell, Adenoma, Multiple 7 (14%) 2 (4%)
C-Cell, Adenoma 9 (18%) 6 (12%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenocarcinoma 7 (14%) 13 (26%)
Follicular Cell, Adenoma 12 (24%) 11 (22%)
Follicular Cell, Adenoma, Multiple 3 (6%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47)
Adenoma 2 (4%) 2 (4%)
Ovary (50) (50)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (50) (50)
Polyp Stromal 7 (14%) 3 (6%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (22) (17)
Bone Marrow (49) (50)
Lymph Node (50) (50)
Lymph Node, Mesenteric (3) (8)
Spleen (50) (50)
Thymus (41) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50)
Adenocarcinoma 2 (4%) 2 (4%)
Fibroadenoma 7 (14%) 9 (18%)
Fibroadenoma, Multiple 1 (2%)
Skin (49) (50)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Carcinoma, Metastatic, Pituitary Gland 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Carcinoma, Metastatic 1 (2%)
Nose (50) (50)
Nasolacrimal Duct, Squamous Cell Papilloma 1 (2%)
Trachea (50) (50)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Squamous Cell Papilloma 1 (100%)
Eye (12) (8)
Harderian Gland (50) (50)
Zymbal's Gland (2) (4)
Carcinoma 2 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Urinary Bladder (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 27 (54%) 25 (50%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50
Total Primary Neoplasms 129 136
Total Animals with Benign Neoplasms 44 42
Total Benign Neoplasms 84 84
Total Animals with Malignant Neoplasms 35 41
Total Malignant Neoplasms 45 52
Total Animals with Metastatic Neoplasms 3 3
Total Metastatic Neoplasm 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Natural Death 10 5 8 7 7 10
Moribund Sacrifice 21 27 20 26 23 25
Survivors
Terminal Sacrifice 18 15 17 15 18 14
Natural Death 1 1 3 1 1
Moribund Sacrifice 2 2 2 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (45) (47) (40) (44) (43) (43)
Intestine Large, Colon (48) (49) (42) (45) (45) (50)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (47) (46) (40) (43) (44) (45)
Intestine Small, Duodenum (48) (49) (46) (47) (49) (49)
Intestine Small, Ileum (45) (47) (42) (43) (45) (46)
Intestine Small, Jejunum (48) (49) (44) (46) (47) (50)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50) (50) (50)
Hepatocellular Adenoma 3 (6%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (3) (5) (6) (2) (2) (3)
Sarcoma 1 (33%)
Pancreas (48) (50) (50) (50) (49) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (49) (50) (50) (50) (50)
Adenoma 1 (2%)
Stomach, Forestomach (49) (50) (47) (50) (48) (49)
Stomach, Glandular (49) (50) (47) (49) (49) (49)
Tongue (2) (1)
Squamous Cell Papilloma 1 (50%) 1 (100%)
Tooth (50) (50) (49) (50) (50) (50)
Gingiva, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49) (50) (49) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (49) (49) (49) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%) 1 (2%) 1 (2%) 4 (8%) 1 (2%)
Pheochromocytoma Benign 16 (32%) 16 (32%) 18 (37%) 15 (31%) 13 (27%) 19 (38%)
Bilateral, Pheochromocytoma Benign 6 (12%) 15 (30%) 6 (12%) 7 (14%) 11 (22%) 5 (10%)
Islets, Pancreatic (48) (50) (50) (50) (49) (50)
Adenoma 2 (4%) 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Parathyroid Gland (44) (46) (48) (45) (45) (47)
Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (48) (47) (49) (49)
Pars Distalis, Adenoma 19 (38%) 15 (30%) 10 (21%) 10 (21%) 13 (27%) 11 (22%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (49) (46) (46) (47) (50)
Bilateral, C-Cell, Adenoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Bilateral, Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
C-Cell, Adenoma 8 (16%) 10 (20%) 9 (20%) 12 (26%) 16 (34%) 12 (24%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenocarcinoma 1 (2%) 3 (6%) 2 (4%) 3 (7%) 4 (9%) 6 (12%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 8 (17%) 9 (19%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50) (49) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Preputial Gland (49) (49) (49) (49) (46) (50)
Adenoma 2 (4%) 4 (8%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Prostate (50) (50) (50) (50) (50) (49)
Page 13
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Seminal Vesicle (1) (1) (4) (1)
Testes (50) (50) (50) (50) (50) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Bilateral, Interstitial Cell, Adenoma 35 (70%) 34 (68%) 39 (78%) 36 (72%) 40 (80%) 40 (80%)
Interstitial Cell, Adenoma 7 (14%) 11 (22%) 5 (10%) 4 (8%) 5 (10%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (17) (25) (24) (21) (24) (26)
Bone Marrow (50) (50) (50) (50) (49) (50)
Lymph Node (50) (50) (50) (50) (48) (50)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Deep Cervical, Mediastinal, Mandibular,
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lumbar, Fibrosarcoma, Metastatic, Skin 1 (2%)
Mandibular, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
Mediastinal, Pheochromocytoma Malignant,
Metastatic, Adrenal Gland 1 (2%)
Mediastinal, Sarcoma, Metastatic, Mesentery 1 (2%)
Lymph Node, Mesenteric (2) (10) (14) (10) (9) (10)
Hemangiosarcoma 1 (10%)
Spleen (50) (50) (50) (50) (50) (50)
Fibrosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Thymus (40) (39) (45) (42) (40) (38)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (40) (42) (37) (45) (41)
Adenocarcinoma 1 (2%)
Adenoma 1 (3%)
Fibroadenoma 1 (3%) 4 (10%) 2 (5%) 1 (2%) 1 (2%)
Skin (50) (49) (50) (50) (49) (50)
Basal Cell Adenoma, Multiple 1 (2%)
Basosquamous Tumor Benign 1 (2%) 2 (4%)
Basosquamous Tumor Benign, Multiple 1 (2%)
Keratoacanthoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Lipoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 3 (6%) 1 (2%) 8 (16%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Page 14
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Leiomyosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Osteosarcoma,
Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Cervical, Osteoma 1 (2%)
Femur, Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1)
Diaphragm, Sarcoma, Metastatic, Mesentery 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Meningioma Benign 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Nose (50) (50) (50) (50) (49) (50)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Trachea (50) (50) (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 15
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2) (1)
Squamous Cell Papilloma 1 (50%)
Harderian Gland (48) (50) (49) (49) (50) (50)
Zymbal's Gland (1) (1) (1) (3) (2) (2)
Carcinoma 1 (100%) 1 (100%) 1 (100%) 3 (100%) 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50) (50) (50)
Cystadenocarcinoma 1 (2%)
Myxoma 1 (2%)
Nephroblastoma 1 (2%)
Capsule, Sarcoma, Metastatic, Mesentery 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Carcinoma, Multiple 1 (2%)
Urinary Bladder (49) (50) (48) (49) (48) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 22 (44%) 32 (64%) 29 (58%) 25 (50%) 31 (62%) 34 (68%)
Mesothelioma Malignant 2 (4%) 2 (4%) 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 16
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50 49 49 49 50
Total Primary Neoplasms 136 173 151 147 179 170
Total Animals with Benign Neoplasms 48 50 46 48 49 49
Total Benign Neoplasms 102 126 106 106 130 118
Total Animals with Malignant Neoplasms 26 40 36 37 39 40
Total Malignant Neoplasms 34 47 45 41 49 52
Total Animals with Metastatic Neoplasms 3 4 1 2 2 2
Total Metastatic Neoplasm 4 5 1 2 4 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 17
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 23 30
Natural Death 8 14
Accidently Killed 5
Survivors
Moribund Sacrifice 1
Natural Death 1
Terminal Sacrifice 14 4
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Intestine Small, Jejunum (42) (45)
Adenocarcinoma 1 (2%)
Liver (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Mesentery (2) (3)
Pancreas (49) (50)
Salivary Glands (50) (49)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Stomach, Forestomach (49) (50)
Stomach, Glandular (49) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Bilateral, Adenoma 1 (2%)
Page 18
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adrenal Gland, Medulla (50) (50)
Pheochromocytoma Malignant 1 (2%) 2 (4%)
Pheochromocytoma Benign 11 (22%) 15 (30%)
Bilateral, Pheochromocytoma Benign 13 (26%) 7 (14%)
Islets, Pancreatic (50) (50)
Adenoma 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (33) (21)
Adenoma 1 (3%)
Pituitary Gland (50) (49)
Pars Distalis, Adenoma 11 (22%) 11 (22%)
Thyroid Gland (50) (50)
Bilateral, Follicular Cell, Adenocarcinoma 11 (22%) 23 (46%)
Bilateral, Follicular Cell, Adenocarcinoma,
Multiple 1 (2%) 1 (2%)
Bilateral, Follicular Cell, Adenoma 6 (12%) 2 (4%)
Bilateral, Follicular Cell, Adenoma, Multiple 2 (4%) 4 (8%)
C-Cell, Adenoma 9 (18%) 3 (6%)
Follicular Cell, Adenocarcinoma 14 (28%) 20 (40%)
Follicular Cell, Adenoma 11 (22%) 20 (40%)
Follicular Cell, Adenoma, Multiple 4 (8%) 8 (16%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50)
Preputial Gland (49) (50)
Adenoma 3 (6%)
Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Prostate (49) (50)
Seminal Vesicle (2)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 30 (60%) 33 (66%)
Interstitial Cell, Adenoma 10 (20%) 12 (24%)
____________________________________________________________________________________________________________________________________
Page 19
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (14) (22)
Bone Marrow (49) (50)
Femoral, Osteosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Lymph Node (50) (49)
Mediastinal, Adenocarcinoma, Metastatic,
Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (14) (10)
Spleen (50) (50)
Thymus (43) (44)
Thymoma Benign 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (49)
Keratoacanthoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Adenocarcinoma,
Metastatic, Thyroid Gland 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (5) (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Nose (50) (50)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
Trachea (50) (50)
Adenocarcinoma, Metastatic, Thyroid Gland 2 (4%)
Page 20
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (49) (50)
Zymbal's Gland (3) (5)
Adenoma 1 (33%)
Carcinoma 2 (67%) 4 (80%)
Bilateral, Carcinoma 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Renal Tubule, Adenoma 3 (6%)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 26 (52%) 29 (58%)
Lymphoma Malignant Histiocytic 1 (2%)
Mesothelioma Malignant 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 21
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:35:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 50
Total Primary Neoplasms 179 212
Total Animals with Benign Neoplasms 45 49
Total Benign Neoplasms 116 125
Total Animals with Malignant Neoplasms 41 50
Total Malignant Neoplasms 63 87
Total Animals with Metastatic Neoplasms 3 6
Total Metastatic Neoplasm 3 11
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 22
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