TR 388 Rat Pathology Tables
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 Facility: Battelle Columbus Laboratory Chemical CAS #: 96-45-7 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4| | 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A A + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | | Degeneration, Cystic | 2 | Fibrosis | 2 | Hepatodiaphragmatic Nodule | | Inflammation, Chronic | 2 2 1 1 2 2 2 1 2 | Necrosis, Coagulative | | Vacuolization Cytoplasmic | 2 2 3 4 2 2 | __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 3 2 3 3 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | 3 | Necrosis, Coagulative | | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 3 3 2 2 2 2 2 2| Mineralization | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4| | 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 2 2 2 | Hyperplasia | 3 2 2 1 2 2 2 2 2 2 2| Hypertrophy | 2 2 | Necrosis, Coagulative | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + M M + + + M + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X X X X X X X X X X X| Pars Distalis, Hyperplasia | 2 3 2 3 3 2 3 3 2 2 3 2| Pars Intermedia, Angiectasis | | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 2 3 1 2 2 2 2 2 2 2 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 1 2 2 | Duct, Dilatation | 4 4 4 4 4 4 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Cervix, Diverticulum | | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 2 1 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | 2 | Femoral, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Cyst | | __________________________________________________________________________| Lymph Node, Mesenteric | + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4| | 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Atrophy | 3 | Fibrosis | 3 | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | M + M + M + + M + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 4 2 3 4 2 1 2 3 3 2 3 2 2 3 3 2 1 4 3 3 2 2 3 4 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Alopecia | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X X | Hemorrhage | | Hydrocephalus | 3 1 1 3 3 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 2 2| Mediastinum, Perivascular, | | Inflammation, Chronic Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + | Hemorrhage | 4 2 | Lens, Cataract | 4 4 4 | Retina, Atrophy | 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4| | 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Mineralization | 3 | Necrosis, Coagulative | | Nephropathy, Chronic | 2 2 1 2 2 2 2 1 3 3 3 3 2 3 3 1 2 3 3 1 2 3 1 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| | | 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + M + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + M + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X | 36 | Clear Cell Focus | X X | 2 | Degeneration, Cystic | | 1 2.0| Fibrosis | | 1 2.0| Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic | 1 1 1 2 1 | 14 1.5| Necrosis, Coagulative | 4 2 | 2 3.0| Vacuolization Cytoplasmic | 4 3| 8 2.8| __________________________________________________________________________|____________| Mesentery | + | 3 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 2 4 1 2 1 1 2 2 2 | 16 2.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | | 1 4.0| __________________________________________________________________________|____________| Stomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 | 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 1 2 1| 4 1.3| Mineralization | | 1 3.0| Necrosis, Coagulative | 4 | 1 4.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| | | 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 3 3 3 2 2 2 2 2 2| 30 2.2| Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 1 2 2 1 2 2 2 3 2 2 2| 16 1.9| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 | 25 2.0| Hypertrophy | 2 | 3 2.0| Necrosis, Coagulative | 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1 2 | 11 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 3 3 | 2 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X X X X X X X X X X X X X | 27 | Pars Distalis, Hyperplasia | 2 3 3 3 2 2 | 18 2.5| Pars Intermedia, Angiectasis | 4 | 1 4.0| Pars Intermedia, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | X | 1 | C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 | 31 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Hyperplasia | 2 2 3 | 3 2.3| Inflammation, Chronic Active | 2 2 4 3 3 4 | 11 2.5| Duct, Dilatation | 4 4 4 4 4 | 11 4.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X X X X X| 11 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 3 | 2 3.5| Cervix, Diverticulum | 4 | 1 4.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 4 2 2 3 | 12 2.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| | | 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + A + | 10 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Reticulum Cell | | 1 2.0| Femoral, Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Cyst | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Fibrosis | | 1 3.0| Hematopoietic Cell Proliferation | 3 3 | 3 3.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + M + + + + + + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 2 2 2 3 4 4 4 3 2 3 4 4 4 3 4 2 3 2 2 3 2 4| 48 2.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alopecia | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 1 | Femur, Fibrous Osteodystrophy | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X X X | 11 | Hemorrhage | 4 | 1 4.0| Hydrocephalus | 2 3 3 2 3 | 10 2.4| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2 | 7 1.7| Mediastinum, Perivascular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| | | 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 1 | 3 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 2 2 2 2 | 7 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + | 8 | Hemorrhage | 2 | 3 2.7| Lens, Cataract | 4 4 4 | 6 4.0| Retina, Atrophy | 4 4 4 | 6 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Mineralization | | 1 3.0| Necrosis, Coagulative | 4 | 1 4.0| Nephropathy, Chronic | 2 2 2 2 4 3 2 3 3 3 2 2 2 1 1 3 4 3 2 2 3 3 1 3 3| 49 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7| DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2| | 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + A + + + + A + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + A + + A +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + M + + + + + + + + + A +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + A + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 3 | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 2 1 2 1 1 1 1| Necrosis, Coagulative | | Vacuolization Cytoplasmic | 3 4 4 4| __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| Cyst | | Acinus, Atrophy | 1 1 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| Acanthosis | 3 | Hyperkeratosis | 3 | Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| Infiltration Cellular, Lymphocyte | 2| Inflammation, Chronic Active | 4 2 3 | Mineralization | | Mucosa, Degeneration, Chronic | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 1 1 2 1 2 2 1 1| Mineralization | | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7| DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2| | 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| Degeneration, Fatty | 3 2 2 1 1 1 1| Hematocyst | | Hyperplasia | 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2| Hypertrophy | 2 1 2 3 2 | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| Hematocyst | X | Hyperplasia | 2 2 2 1 2 2 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia | 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | X X X X X X X | Pars Distalis, Hyperplasia | 3 2 2 3 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + A + + + + + + + + + + + + + + + A + + + +| Inflammation, Chronic Active | | Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 2 2 2 2 3 1 2 2 2 2 3 2 2 3| Follicular Cell, Hyperplasia | 1 1 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 | Inflammation, Chronic Active | 2 3 2 3 1 | Duct, Dilatation | 3 3 3 4 3 3 3 4 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cyst | X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 3 4 4 | Hemorrhage | | Inflammation, Chronic Active | 1 | Prolapse | | Cervix, Diverticulum | 4 4 | Cervix, Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7| DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2| | 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Endometrium, Hyperplasia, Cystic, | | Glandular | 3 4 4 3 4 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | 4 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + M M +| Hyperplasia, Cystic | 3 3 3 2 2 3 2 2 4 3 3 2 2 3 3 1 2 2 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | Cranium, Fibrous Osteodystrophy | X | Femur, Fibrous Osteodystrophy | X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X| Hydrocephalus | 3 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 1 | Alveolar Epithelium, Hyperplasia | 2 | Artery, Mediastinum, Mineralization | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7| DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2| | 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + + | Lens, Cataract | 4 4 | Retina, Atrophy | 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| Nephropathy, Chronic | 3 2 2 1 2 2 3 3 4 3 2 2 2 2 2 1 2 2 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + A +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| | DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| | | 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 | Parasite Metazoan | X X X | 6 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X| 31 | Clear Cell Focus | X X X | 4 | Degeneration, Cystic | 2 2 | 2 2.0| Eosinophilic Focus | X | 1 | Hematopoietic Cell Proliferation | | 1 3.0| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Chronic | 2 2 1 1 1 1 2 2 2| 17 1.4| Necrosis, Coagulative | 2 | 1 2.0| Vacuolization Cytoplasmic | | 4 3.8| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X | 1 | Acinus, Atrophy | 1 1 2 2 1 2 2 1| 12 1.4| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 3 | 2 3.0| Hyperkeratosis | 3 | 2 3.0| Inflammation, Chronic Active | 2 | 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Lymphocyte | | 1 2.0| Inflammation, Chronic Active | 2 | 4 2.8| Mineralization | 2 3 1 | 3 2.0| Mucosa, Degeneration, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| | DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| | | 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 2 1 2 3 2 2 2 2 2 2 2 2 2| 25 1.8| Mineralization | 4 | 1 4.0| Atrium, Thrombosis | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | 2 1 1 2 2 1 2 1 1 2 1 2 2| 20 1.6| Hematocyst | X | 1 | Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 3 3 2 3 2 2 2| 33 2.1| Hypertrophy | 2 1 1 2 2 3 | 11 1.9| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematocyst | | 1 | Hyperplasia | 2 2 2 2 2 1 1 | 16 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + M + + + + + + + +| 47 | Hyperplasia | 3 | 3 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 3 | 1 3.0| Pars Distalis, Cyst | X X X X X X X X X X| 17 | Pars Distalis, Hyperplasia | 2 2 2 2 2 2| 12 2.2| Pars Intermedia, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 | 1 2.0| Ultimobranchial Cyst | X X | 3 | C-Cell, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0| Follicular Cell, Hyperplasia | 1 2 1 | 8 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 4 2.0| Inflammation, Chronic Active | 2 4 2 3 2 2 | 11 2.4| Duct, Dilatation | 3 4 4 3 4 4 | 14 3.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| | DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| | | 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 2 3.0| Cyst | X X X X X X X X X X X X | 19 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3| 5 3.2| Hemorrhage | 3 | 1 3.0| Inflammation, Chronic Active | 2 1 | 3 1.3| Prolapse | X | 1 | Cervix, Diverticulum | 4 | 3 4.0| Cervix, Inflammation, Suppurative | 4 | 2 4.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 4 2 3 2 3| 12 3.0| __________________________________________________________________________|____________| Vagina | + + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + | 10 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Reticulum Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Hematopoietic Cell Proliferation | 3 3 3 | 4 3.0| Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + M M + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Cystic | 4 3 1 4 3 2 3 3 2 2 4 2 3 2 3 2 2 2 3 2 2 2 2 2 2| 45 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cranium, Fibrous Osteodystrophy | X | 2 | Femur, Fibrous Osteodystrophy | X | 2 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| | DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| | | 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Compression | X X X | 7 | Hydrocephalus | 2 2 2 | 6 2.2| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 1 1 2 3 1 1 1| 11 1.5| Alveolar Epithelium, Hyperplasia | | 1 2.0| Artery, Mediastinum, Mineralization | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 3 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 2| 4 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + | 9 | Lens, Cataract | 4 4 4 4 4 | 7 4.0| Retina, Atrophy | 4 4 4 4 4 4 | 8 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy, Chronic | 3 2 2 2 2 1 2 3 2 1 1 3 2 3 2 2 3 2 4 2 2 1 3 2| 43 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| | 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Artery, Necrosis, Fibrinoid | 4 | Perivascular, Inflammation, Chronic | | Active | 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | | Hyperplasia | | Inflammation, Chronic | 1 1 1 1 1 1 1 2 | Necrosis, Coagulative | 3 | Thrombosis | X | Vacuolization Cytoplasmic | 4 3 3 4 4| __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 1 2 1 2 2 2 2 | Artery, Necrosis, Fibrinoid | 4 | Perivascular, Inflammation, Chronic | | Active | 3 3 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 | Hyperkeratosis | 3 2 | Hyperplasia, Focal, Squamous | | Inflammation, Chronic Active | 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 2| Mineralization | 2 1 | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| | 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy, Chronic | 2 2 2 1 2 2 2 2 2 1 2 2 2 2 | Atrium, Thrombosis | X| Ventricle, Thrombosis | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | X | Degeneration, Fatty | 3 2 3 1 2 2 3 1 2 2 2| Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 | Hypertrophy | 2 2 3 2 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + I + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X X X X X X X X X X X X X | Pars Distalis, Hyperplasia | 2 3 2 2 2 2 | Pars Intermedia, Cyst | X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | 2 | C-Cell, Hyperplasia | 2 2 1 2 2 1 1 2 1 2 1 2 1 1 2 1 1 2 1 2 2 2| Follicular Cell, Hyperplasia | 1 1 1 2 1 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2| Inflammation, Chronic Active | 1 1 1 1 1 1 1 | Duct, Dilatation | 1 4 1 2 1 1 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 | Cyst | X X X X X X X | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Inflammation, Chronic Active | 4 | Cervix, Diverticulum | | Cervix, Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 4 1 3 | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| | 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | 4 | __________________________________________________________________________| Thymus | + + + + M + M + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 3 3 3 4 3 2 3 2 2 3 1 4 2 2 2 3 3 1 4 4 2 2 4 3| Inflammation, Chronic Active | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hydrocephalus | 3 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 1 1 | Alveolar Epithelium, Hyperplasia | 2 | Artery, Mediastinum, Necrosis, | | Fibrinoid | | Mediastinum, Perivascular, | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 2 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Hemorrhage | 4 | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| | 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Inflammation, Chronic Active | 3 | Lens, Cataract | 4 | Retina, Atrophy | 3 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy, Chronic | 1 3 4 1 1 2 2 2 2 3 2 2 2 3 3 2 1 4 2 3 1 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| | | 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Artery, Necrosis, Fibrinoid | | 1 4.0| Perivascular, Inflammation, Chronic | | | Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Parasite Metazoan | X X| 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X| 34 | Clear Cell Focus | X | 2 | Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 3 | 1 3.0| Inflammation, Chronic | 1 1 1 2 1 1 2 1 3 2 1 1 1| 21 1.3| Necrosis, Coagulative | 2 | 2 2.5| Thrombosis | | 1 | Vacuolization Cytoplasmic | 3 2 2 2 | 9 3.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 2 1 2 2 3 1 1| 17 1.7| Artery, Necrosis, Fibrinoid | | 1 4.0| Perivascular, Inflammation, Chronic | | | Active | | 3 3.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 | 3 2.7| Hyperkeratosis | 2 | 3 2.3| Hyperplasia, Focal, Squamous | 4 | 1 4.0| Inflammation, Chronic Active | 2 2 1 | 5 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 3 2.7| Mineralization | 2 2 2 | 5 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| | | 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 3 2 2 2 1 2 2 1 1 2 1 2 | 27 1.8| Atrium, Thrombosis | | 1 | Ventricle, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atypia Cellular | X| 2 | Degeneration, Fatty | 1 1 2 1 1 2 1 2 1 3 1 2| 23 1.8| Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 26 2.0| Hypertrophy | 2 2 3 | 8 2.4| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 1 2| 8 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | X X X X X X X X X X X| 27 | Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2| 13 2.2| Pars Intermedia, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Ultimobranchial Cyst | | 1 2.0| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2| 41 1.7| Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 | 15 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 | 3 2.0| Inflammation, Chronic Active | 1 1 | 9 1.0| Duct, Dilatation | 3 | 8 1.8| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| | | 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | 3 | 3 3.0| Cyst | X X X X X X X X X X X | 18 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 | 3 2.3| Inflammation, Chronic Active | | 1 4.0| Cervix, Diverticulum | 4 | 1 4.0| Cervix, Inflammation, Suppurative | 3 | 1 3.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 4 2 2 2 1 | 10 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 16 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 2 2.0| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis, Coagulative | 4 | 2 4.0| __________________________________________________________________________|____________| Thymus | + M + + + + + M + + + + + + + + + + + M + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 2 3 2 2 2 2 4 2 4 2 3 1 2 2 2 3 3 4 4 2 3 2 3 3| 50 2.6| Inflammation, Chronic Active | 2 3 | 2 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X X X | 8 | Hydrocephalus | 3 2 2 2 3 3 3 | 9 2.7| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| | | 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 3| 13 1.4| Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| Artery, Mediastinum, Necrosis, | | | Fibrinoid | 3 | 1 3.0| Mediastinum, Perivascular, | | | Inflammation, Chronic Active | 3 | 2 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 | 5 2.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + | 7 | Hemorrhage | | 1 4.0| Inflammation, Chronic Active | | 1 3.0| Lens, Cataract | 4 4 4 | 4 4.0| Retina, Atrophy | 4 4 4 | 5 3.8| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Nephropathy, Chronic | 2 1 2 2 2 1 2 3 2 3 3 1 2 2 3 1 2 2 1 3 3 3 2| 46 2.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4| | 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + A + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + A + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + A + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + A + + + + + + + A + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + A + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + A + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | | Degeneration, Cystic | 2 2 | Hepatodiaphragmatic Nodule | X | Hyperplasia | 3 | Inflammation, Chronic | 1 2 2 1 3 2 2 2 1 1 1| Necrosis, Coagulative | 2 2 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 2 2 2 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Hyperkeratosis | 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| Inflammation, Chronic Active | 2 2 2 2 2 | Mineralization | 2 | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 1| Mineralization | | Atrium, Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4| | 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Degeneration, Fatty | 1 3 2 2 1 1 2 2 1 | Hematocyst | X | Hyperplasia | 2 2 3 2 1 3 2 2 2 1 2 2 2 2 1 2| Hypertrophy | 2 2 2 2 | Necrosis, Coagulative | 2 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 2 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + M + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Atypia Cellular | X | Pars Distalis, Cyst | X X X X X X X X X X X X X| Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2| Pars Intermedia, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + A + +| Ultimobranchial Cyst | X X X | C-Cell, Hyperplasia | 2 2 1 2 2 2 2 1 1 1 2 2 1 2 1 1 2| Follicular Cell, Hyperplasia | 1 1 2 2 1 2 2 2 2 2 2 2 2 2 4 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 3 2 1 3 2| Duct, Dilatation | 1 2 1 1 2 2 1 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 | Cyst | X X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3 4 3 | Hemorrhage | 4 | Inflammation, Chronic Active | 2 | Cervix, Diverticulum | 4 | Cervix, Inflammation, Suppurative | 3 | Endometrium, Hyperplasia, Cystic, | | Glandular | 1 4 1 2 1 2 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4| | 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | 2 4 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 4 | __________________________________________________________________________| Thymus | + + + + + M + + + M + + + M + + + + + + + + M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 2 2 4 3 2 2 4 4 2 2 1 3 2 2 4 3 3 4 2 4 3 1 2 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Alopecia | X | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X X X X X | Hydrocephalus | 2 2 3 3 2 2 2 | Thrombosis | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 3 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4| | 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Inflammation, Chronic Active | 4 | Lens, Cataract | 2 4 | Retina, Atrophy | 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Nephropathy, Chronic | 1 2 1 2 3 3 2 2 2 4 2 2 2 3 3 2 2 4 2 1 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| | | 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | A + + + + + + + + + A + + + + + + + A + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + A + + + A + + + A + + + A + +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | M + + + + + + + + + A + + + + + + + A + + + + + +| 45 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + + + + A + + + A + + + A + + + + + +| 43 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small | A + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + + + + + + + A + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + A + + + A + + + A + + + A + +| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + + + + + A + + + + + + + A + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X| 31 | Clear Cell Focus | X | 1 | Degeneration, Cystic | | 2 2.0| Hepatodiaphragmatic Nodule | | 1 | Hyperplasia | | 1 3.0| Inflammation, Chronic | 2 1 3 1 1 1 1| 18 1.6| Necrosis, Coagulative | 3 | 3 2.3| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 2 2 4 2 2 2 2 2| 15 1.9| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 2 | 3 2.0| Hyperkeratosis | 2 2 | 3 2.0| Inflammation, Chronic Active | 3 4 | 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 2 2 3 | 9 2.1| Mineralization | 2 | 2 2.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| | | 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy, Chronic | 2 2 2 2 1 1 1 2 2 2 1 2 2 2 2 3 2 2 2 2 2| 38 1.8| Mineralization | 2 | 1 2.0| Atrium, Thrombosis | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 48 | Accessory Adrenal Cortical Nodule | X | 1 | Degeneration, Fatty | 2 1 2 2 2 2 2 2 2 2 2 1 2 | 22 1.8| Hematocyst | X | 2 | Hyperplasia | 2 1 3 1 2 2 2 2 2 2 2 3 2 3 2 | 31 2.0| Hypertrophy | 2 3 2 | 7 2.1| Necrosis, Coagulative | | 2 2.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 2 2 2 2 | 14 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 2 | 1 2.0| Pars Distalis, Atypia Cellular | | 1 | Pars Distalis, Cyst | X X X X X X X X X X X X X X X | 28 | Pars Distalis, Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia | 2 3 3 2 2 2 | 13 2.2| Pars Intermedia, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | A + + + + + + + + + A + + + + + + + A + + + A + +| 44 | Ultimobranchial Cyst | | 3 | C-Cell, Hyperplasia | 2 2 2 2 2 1 1 1 1 2 2 2 3 1 2 1 1 1| 35 1.6| Follicular Cell, Hyperplasia | 2 2 1 2 2 3 1 1 2 2 2 2 1 2 1 | 33 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | A + + + M + + + + + + + + + + + + + + M + + + + +| 47 | Hyperplasia | 2 2 2 | 3 2.0| Inflammation, Chronic Active | 2 2 2 2 2 1 1 2 3| 15 2.0| Duct, Dilatation | | 8 1.6| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| | | 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | | 3 3.0| Cyst | X X X X X X X X X X X X X | 21 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 4 | 6 3.3| Hemorrhage | 4 4 | 3 4.0| Inflammation, Chronic Active | | 1 2.0| Cervix, Diverticulum | | 1 4.0| Cervix, Inflammation, Suppurative | | 1 3.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 1 4 2 4 2 4 2 2| 14 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 14 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Reticulum Cell | | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + +| 14 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 4 4 1 3 1 3 3 3 3 3 2 3 2 2 3 3 2 2 3 3 2 2 3| 47 2.6| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alopecia | | 1 | Inflammation, Chronic Active | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X X | 2 | Femur, Fibrous Osteodystrophy | X X | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| | | 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hydrocephalus | 3 | 8 2.4| Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 4 1| 12 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 4 | 4 2.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + | 7 | Inflammation, Chronic Active | | 1 4.0| Lens, Cataract | 3 4 3 4 | 6 3.3| Retina, Atrophy | 4 4 3 4 | 6 3.8| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| Nephropathy, Chronic | 3 2 2 1 3 2 3 1 1 1 3 1 4 1 2 2 1 4 3 1 1 2| 43 2.1| __________________________________________________________________________|____________| Urinary Bladder | A + + + + + + + + + A + + + + + + + A + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7| DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4| | 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + A + + + + + A + A + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + A + A A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + A + M + + + + + + + + + + + A +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + A + A + A + + + + + + + + + + + A +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + A + + A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + A + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X| Clear Cell Focus | X | Degeneration, Cystic | 3 | Hepatodiaphragmatic Nodule | X X| Inflammation, Chronic | 1 1 1 1 1 1 2 1| Leukocytosis | | Necrosis, Coagulative | 4 2 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic Active | 3 | Artery, Inflammation, Chronic Active | | Artery, Necrosis, Fibrinoid | | __________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Ectopic Liver | | Acinus, Atrophy | 2 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 1 1 4 2 2 | Mineralization | 1| __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Caries | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7| DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4| | 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | X| Degeneration, Fatty | 3 2 1 2 1 2 2 2 1 1 | Hyperplasia | 2 1 2 2 3 2 2 2 2 1 2| Hypertrophy | 1 3 2 2 3| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 1 1 1 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X X X X X X X X X X| Pars Distalis, Fibrosis | | Pars Distalis, Hyperplasia | 2 2 2 2| Pars Distalis, Vacuolization | | Cytoplasmic | 4 | __________________________________________________________________________| Thyroid Gland | + + + A + + + A + A + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | Artery, Inflammation, Chronic Active | | Artery, Necrosis, Fibrinoid | | C-Cell, Hyperplasia | 3 2 2 2 1 1 2 2 2 2 2 2 1 2 1| Follicular Cell, Hyperplasia | 1 2 1 1 3 3 2 2 2 2 3 3 2 2 2 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 1 1 3 | Duct, Dilatation | 3 3 4 4 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cyst | X X X X X X | Inflammation, Chronic Active | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Inflammation, Chronic Active | 2 | Cervix, Diverticulum | 4 | Cervix, Inflammation, Suppurative | 2 | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7| DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4| | 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + A +| Femoral, Hyperplasia, Reticulum Cell | | Femoral, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Fibrosis | | Hematopoietic Cell Proliferation | | Necrosis, Coagulative | 4 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 1 2 3 2 3 2 3 2 4 4 3 2 3 3 4 3 3 4 3 2 2 2 3 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X | Femur, Fibrous Osteodystrophy | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hemorrhage | 2 4 3 | Hydrocephalus | 3 2 | Artery, Inflammation, Chronic Active | | Artery, Necrosis, Fibrinoid | | __________________________________________________________________________| Peripheral Nerve | M | __________________________________________________________________________| Spinal Cord | + | White Matter, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 1| Leukocytosis | | Necrosis, Coagulative | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| Fungus | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7| DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4| | 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic Active | 3 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + | Lens, Cataract | 4 4 4 3 3 4 | Retina, Atrophy | 4 4 4 3 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hydronephrosis | 3 | Nephropathy, Chronic | 1 2 2 2 3 3 4 3 2 3 4 2 3 2 2 2 1 2| __________________________________________________________________________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| | | 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + A + + + + + + + + + + + + + A + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + A + + + + M + + + A + + + + + A + + +| 39 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + A + + + + + A + + +| 43 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + A + + + + M + + + A + + + + + + + + +| 41 | Parasite Metazoan | X X X X | 7 | __________________________________________________________________________|____________| Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 4 4 | 2 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + M + + + + + + + + + + A + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X| 23 | Clear Cell Focus | | 1 | Degeneration, Cystic | | 1 3.0| Hepatodiaphragmatic Nodule | | 2 | Inflammation, Chronic | 1 2 2 1 2 2 2 2| 16 1.4| Leukocytosis | X | 1 | Necrosis, Coagulative | 4 | 3 3.3| Vacuolization Cytoplasmic | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Inflammation, Chronic Active | 3 | 2 3.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| Artery, Necrosis, Fibrinoid | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ectopic Liver | X | 1 | Acinus, Atrophy | 2 3 1 2 1 2 2 3 1 2 2| 14 1.9| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 3 4 | 9 2.6| Mineralization | 2 1 2 | 4 1.5| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Caries | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| | | 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 1 3 2 2 1 2 2 2 2 2 2 1 2| 33 1.9| Atrium, Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atypia Cellular | | 1 | Degeneration, Fatty | 3 3 2 1 1 2 1 3 2 3| 20 1.9| Hyperplasia | 2 2 1 2 2 2 2 1 2 3 2 2 1 2 1 2| 27 1.9| Hypertrophy | 2 1 3| 8 2.1| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 1 2 2 2 1| 15 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + + + + M + + + + + + + +| 46 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Pars Distalis, Cyst | X X X X X X X X X X X X X X X X| 29 | Pars Distalis, Fibrosis | 3 | 1 3.0| Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 3 | 12 2.2| Pars Distalis, Vacuolization | | | Cytoplasmic | | 1 4.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 | Ultimobranchial Cyst | X X | 2 | Artery, Inflammation, Chronic Active | 3 | 1 3.0| Artery, Necrosis, Fibrinoid | 2 | 1 2.0| C-Cell, Hyperplasia | 2 2 1 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2| 33 1.8| Follicular Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2| 30 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 3 | 2 2.5| Inflammation, Chronic Active | 2 3 2 2 2| 8 2.0| Duct, Dilatation | 4 3 | 6 3.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| | | 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | 3 | 2 3.0| Cyst | X X X X X X X X| 14 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| Inflammation, Chronic Active | | 1 2.0| Cervix, Diverticulum | | 1 4.0| Cervix, Inflammation, Suppurative | | 1 2.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 2 4 | 11 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 18 | __________________________________________________________________________|____________| Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 | Femoral, Hyperplasia, Reticulum Cell | 3 | 1 3.0| Femoral, Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | A + + + + + | 14 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 | 1 3.0| Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + M + + + + M + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 4 2 1 4 4 2 3 2 2 2 2 2 4 3 2 4 4 4 3 1 2 3 3 2| 49 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | | 1 | Femur, Fibrous Osteodystrophy | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| | | 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | 4 | 4 3.3| Hydrocephalus | 2 | 3 2.3| Artery, Inflammation, Chronic Active | 3 | 1 3.0| Artery, Necrosis, Fibrinoid | 2 | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | | __________________________________________________________________________|____________| Spinal Cord | | 1 | White Matter, Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 2 2 1 1| 10 1.2| Leukocytosis | X | 1 | Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fungus | X X | 2 | Inflammation, Chronic Active | 3 3 | 4 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 3 3 4 1 | 7 2.6| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + | 12 | Lens, Cataract | 4 4 4 3 4 | 11 3.7| Retina, Atrophy | 4 4 4 4 | 10 3.9| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lacrimal Gland | +| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Hydronephrosis | | 1 3.0| Nephropathy, Chronic | 2 2 1 1 1 2 2 2 3 2 2 3 1 2 1 3 2 2 1 2 1 2 2| 41 2.1| __________________________________________________________________________|____________| Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Dilatation | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4| | 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 4 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + A + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + A + A| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + A| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + A + + + A + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Basophilic Focus | X X X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 2 2 1 2 3 1 | Necrosis, Coagulative | | Hepatocyte, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + + | Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 1 3 3 2 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | 4 | Necrosis, Coagulative | 4 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 2 2 | Mineralization | 1 | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | X | Cardiomyopathy, Chronic | 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 2 3 3| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4| | 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Artery, Necrosis, Fibrinoid | 3 | Perivascular, Inflammation, Chronic | | Active | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Inflammation, Chronic | 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | | Degeneration, Fatty | 2 3 2 2 2 1 1 2 2 1 2 2 3 | Hematocyst | X | Hyperplasia | 3 1 2 3 2 2 1 1 2 3 2 1 2 2 1 2 2 2 3 2| Hypertrophy, Focal | | Hypertrophy | 2 2 | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 2 | Infiltration Cellular, Lymphocyte | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | X X X X X X X X X X X X X X | Pars Distalis, Hyperplasia | 2 2 2 3 2 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + A| C-Cell, Hyperplasia | 2 2 1 3 2 1 3 2 3 2 2 3 2 2 2 2 2 2 2 | Follicular Cell, Hyperplasia | 1 3 3 2 2 3 2 2 2 1 2 1 2 2 2 2 2 2 3 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + + + + + M + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 2 | Duct, Dilatation | 4 4 3 4 3| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cyst | X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Hemorrhage | 4| Endometrium, Hyperplasia, Cystic, | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4| | 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Glandular | 2 4 2 1 3 2 4 1 2 | __________________________________________________________________________| Vagina | | Dilatation | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | | Necrosis, Coagulative | 4 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 3 3 2 4 3 3 2 3 4 3 3 3 3 3 2 1 3 2 4 3 4 3 2| __________________________________________________________________________| Skin | + + + + + + + + + + M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X | Hydrocephalus | 2 2 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Spinal Cord | + | White Matter, Degeneration | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 | Bronchiole, Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Chronic Active | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 1 2 | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4| | 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + | Inflammation, Chronic Active | 4 | Lens, Cataract | 4 3 4 4 4 4 4 | Retina, Atrophy | 4 4 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Necrosis, Coagulative | 3 | Nephropathy, Chronic | 2 1 2 2 1 2 3 2 3 2 4 1 2 2 2 2 2 2 2 2 2 2 4 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| | | 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 4.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X X| 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Basophilic Focus | X X X X X X X X X X X X X X X X X| 28 | Clear Cell Focus | | 1 | Degeneration, Cystic | 2 | 1 2.0| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Chronic | 2 1 2 1 1 2 2 2 2 1 2 1 2 | 20 1.7| Necrosis, Coagulative | 1 | 1 1.0| Hepatocyte, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Inflammation, Chronic Active | 3 4 3 | 5 3.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 1 2 3 1 1 2 | 17 1.7| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 1 3.0| Hyperkeratosis | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 2 3.0| Necrosis, Coagulative | | 2 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 5 2.0| Mineralization | 2 2 2 2 2| 6 1.8| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| | | 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bacterium | | 1 | Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 1 1 2 1 2| 35 1.9| Inflammation, Chronic Active | | 1 3.0| Artery, Necrosis, Fibrinoid | | 1 3.0| Perivascular, Inflammation, Chronic | | | Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | X | 1 | Degeneration, Fatty | 2 2 2 1 3 2 1 2 1 3 | 23 1.9| Hematocyst | | 1 | Hyperplasia | 3 3 3 3 2 2 3 2 2 2 2 2 2 2 2 2| 36 2.1| Hypertrophy, Focal | 3 | 1 3.0| Hypertrophy | 2 2 | 4 2.0| Necrosis, Coagulative | 3 2 | 2 2.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 3 2 2 2 2 2 2 | 13 1.9| Infiltration Cellular, Lymphocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + M| 47 | Hyperplasia | 4 | 2 3.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Pars Distalis, Angiectasis | 2 2 | 2 2.0| Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X| 31 | Pars Distalis, Hyperplasia | 1 3 2 3 2 | 12 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | C-Cell, Hyperplasia | 2 2 2 3 2 2 1 2 2 2 2 2 1 2 2 1 2 1 2 2| 39 2.0| Follicular Cell, Hyperplasia | 2 3 3 2 1 2 3 2 3 2 2 2 3 3 3 1 1 2 2 1| 41 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| | | 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + M + + + + + + M + + + + + + + M +| 45 | Inflammation, Chronic Active | 2 1 3 2 3 3 2 2 3 2 2| 14 2.3| Duct, Dilatation | 3 4 4 3 4 3 3 3 | 13 3.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Cyst | X X X X X X| 13 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| Hemorrhage | 4 | 2 4.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 4 1 4 2 3 | 15 2.5| __________________________________________________________________________|____________| Vagina | + | 1 | Dilatation | 3 | 1 3.0| Epithelium, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + | 11 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 3 | 2 3.0| Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M M + + M M + + + + + + M| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 2 2 2 2 3 4 4 3 3 4 3 3 4 3 4 2 3 2 2 1 4 1| 47 2.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 1 | Femur, Fibrous Osteodystrophy | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| | | 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Compression | X | 5 | Hydrocephalus | 2 | 4 2.3| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | White Matter, Degeneration | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 1 1 1 1 2 | 9 1.2| Bronchiole, Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X | 1 | Inflammation, Chronic Active | 1 2 | 3 1.7| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 3 2 | 6 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 10 | Inflammation, Chronic Active | | 1 4.0| Lens, Cataract | 4 4 | 9 3.9| Retina, Atrophy | 4 4 | 7 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 2 | Necrosis, Coagulative | 2 | 2 2.5| Nephropathy, Chronic | 2 2 3 2 2 2 4 2 2 3 3 2 3 4 2 1 2 3 2 2 2| 45 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1| | 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Glandular | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | 2 4 | Hepatodiaphragmatic Nodule | X X | Inflammation, Chronic | 2 1 1 1 1 1 | Leukocytosis | | Necrosis, Coagulative | 3 | Vacuolization Cytoplasmic | 3| Bile Duct, Hyperplasia | 3 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 3 2 1 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | Mineralization | 1 | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 | Inflammation, Chronic Active | 3 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1| | 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | X | Degeneration, Fatty | 1 2 3 2 2 2 2 2 2 2 3 | Hyperplasia | 3 2 2 2 2 3 3 2 2 2 2 | Hypertrophy | 2 2 3 | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 3 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + M + + M + + + + M + M + M + + + + + M +| Hyperplasia | 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X X X X | Pars Distalis, Hyperplasia | 2 2 2 2 1 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 1 1 2 1 1 2 3 2 2 2 1 3 3 1 2 3 1| Follicular Cell, Hyperplasia | 2 2 2 3 1 2 3 3 2 4 2 2 3 4 4 3 1 4 3 4 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 2 4 | Duct, Dilatation | 4 3| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Inflammation, Chronic Active | 2 | Cervix, Diverticulum | | Cervix, Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic, | | Glandular | 3 2 | __________________________________________________________________________| Vagina | +| Inflammation, Suppurative | 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1| | 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Cyst | X | __________________________________________________________________________| Lymph Node, Mesenteric | M + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + M + + + + + + + + M + M M + + + + M + + + + + +| Cyst | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 4 3 4 2 2 4 2 3 2 2 2 3 3 2 2 3 3 3 2 2 3 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X | Femur, Fibrous Osteodystrophy | X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X| Hemorrhage | | Hydrocephalus | 3 3 3 3 4| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 2 | Leukocytosis | | Alveolar Epithelium, Hyperplasia | 3 | Artery, Mediastinum, Inflammation, | | Chronic Active | 4 | Artery, Mediastinum, Necrosis, | | Fibrinoid | 3 | Mediastinum, Hemorrhage | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | X | Hemorrhage | 3 | Inflammation, Chronic Active | 4 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1| | 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + | Hemorrhage | | Lens, Cataract | 3 4 4 4 | Retina, Atrophy | 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy, Chronic | 3 2 2 3 1 2 3 2 2 2 4 1 1 2 1 2 2 1 4 1 4 1 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| | DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| | | 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + A + + + + + + + + + + + + + + + + + +| 46 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + M + + + A + + + + + + + + + + + + + + + + + +| 46 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + A + M + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Glandular | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + M + + + A + + + + + + + M + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + A + + + + + + + A + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X | 16 | Clear Cell Focus | X | 2 | Degeneration, Cystic | 2 | 3 2.7| Hepatodiaphragmatic Nodule | X | 3 | Inflammation, Chronic | 1 2 2 2 2 2 2 2 2 | 15 1.6| Leukocytosis | X X X | 3 | Necrosis, Coagulative | 3 2 3 | 4 2.8| Vacuolization Cytoplasmic | 2 2 3 | 4 2.5| Bile Duct, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic Active | 3 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 1 2 3 1 3 2 2 3 | 14 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 3 2 | 5 2.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2 2| 6 2.0| Mineralization | 1 | 2 1.0| __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3| 2 3.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| | DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| | | 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.0| Inflammation, Chronic Active | | 1 3.0| Atrium, Thrombosis | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | | 1 | Degeneration, Fatty | 2 3 1 2 2 2 2 2 2 2 2 | 22 2.0| Hyperplasia | 2 2 2 1 2 3 2 2 2 3 2 | 22 2.2| Hypertrophy | 2 | 4 2.3| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 8 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M M + + + + M + + + M + + + M + + M + +| 37 | Hyperplasia | 2 | 3 2.7| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X X X X X X X X X X| 17 | Pars Distalis, Hyperplasia | 3 2 2 2 2 2 | 12 2.0| Pars Intermedia, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | 1 2 2 2 2 1 3 1 1 1 2 2 2 1 1 | 33 1.7| Follicular Cell, Hyperplasia | 4 2 3 4 4 4 2 2 3 3 3 4 2 2 3 2 2 2 2 3 3 2 3 | 45 2.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + M + + M + + + + + + + + + + + + +| 47 | Hyperplasia | 4 3 | 2 3.5| Inflammation, Chronic Active | 3 2 4 2 2| 9 2.6| Duct, Dilatation | 3 3 4 4 | 6 3.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X X | 9 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| | DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| | | 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cervix, Diverticulum | 3 4 | 2 3.5| Cervix, Inflammation, Suppurative | 3 3 | 2 3.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 3 2 | 4 2.5| __________________________________________________________________________|____________| Vagina | | 1 | Inflammation, Suppurative | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + +| 22 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pancreatic, Cyst | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 3 | 3 3.0| __________________________________________________________________________|____________| Thymus | + + + + + M + + + + M + + + + M + + + + + + + + M| 41 | Cyst | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 4 2 2 3 2 3 2 2 3 3 2 2 4 2 2 2 2 4 4 4 2 3 2 2 2| 47 2.6| __________________________________________________________________________|____________| Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | | 2 | Femur, Fibrous Osteodystrophy | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X | 7 | Hemorrhage | 2| 1 2.0| Hydrocephalus | 2 2 2 | 8 2.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 3 | 5 2.8| Leukocytosis | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| | DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| | | 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | | 1 3.0| Artery, Mediastinum, Inflammation, | | | Chronic Active | | 1 4.0| Artery, Mediastinum, Necrosis, | | | Fibrinoid | | 1 3.0| Mediastinum, Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 3 | 1 3.0| Fungus | X | 2 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 3 3 | 4 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 3 2| 4 2.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + + +| 12 | Hemorrhage | 4| 1 4.0| Lens, Cataract | 3 3 4 3 4 | 9 3.6| Retina, Atrophy | 4 4 4 4 4 | 8 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Nephropathy, Chronic | 1 1 2 4 3 1 1 2 3 1 2 2 2 2 2 3 3 3 1 4 2 2 1| 48 2.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6| DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1| | 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X | Clear Cell Focus | X X X | Cyst | | Inflammation, Chronic | 1 2 1 2 1 1 2 | Necrosis, Coagulative | 3 2 2 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 2 1 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2| __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 3 2 2 | Inflammation, Chronic Active | | Atrium, Thrombosis | X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 2 2 2 2 | Hyperplasia | 2 2 2 1 1 1 1 1 2 3 2| Hypertrophy | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6| DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1| | 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Atypia Cellular | X X | Pars Distalis, Cyst | X X X X X X X X X X X X X| Pars Distalis, Hyperplasia | 2 2 3 2 2 3 | Pars Intermedia, Cyst | X | Pars Nervosa, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 3 2 | Follicular Cell, Hyperplasia | 4 2 2 3 3 3 3 3 3 3 3 3 2 2 3 3 3 3 2 2 1 3 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia | | Inflammation, Chronic Active | 1 2 4 2 2 | Duct, Dilatation | 1 2 4 2 2 1 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cyst | X X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cervix, Diverticulum | 4 | Cervix, Inflammation, Suppurative | 3 | Endometrium, Hyperplasia, Cystic, | | Glandular | 1 2 2 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Inflammation, Chronic Active | 4 | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + M + + M + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6| DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1| | 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 3 4 3 3 3 4 3 2 2 3 3 2 2 3 3 3 2 2 3 3 2 3 2 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X X | Hemorrhage | | Hydrocephalus | 3 3 3 3 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Chronic Active | 4 3 1 1 2 | Alveolar Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Chronic Active | 2 1 | Mucosa, Nasolacrimal Duct, | | Hyperplasia | | Nasolacrimal Duct, Dilatation | | Nasolacrimal Duct, Hyperkeratosis | | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + | Lens, Cataract | 4 | Retina, Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Zymbal's Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6| DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1| | 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cyst | | Inflammation, Chronic Active | 4 | Necrosis, Coagulative | | Nephropathy, Chronic | 3 1 2 2 2 1 3 3 3 2 3 2 2 1 2 3 2 3 2 2 1 1 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| | | 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X| 11 | Clear Cell Focus | X | 4 | Cyst | X | 1 | Inflammation, Chronic | 2 2 2 3 1 1 1 2 | 15 1.6| Necrosis, Coagulative | 2 | 4 2.3| Vacuolization Cytoplasmic | 3 | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 2 3 2 2 | 10 1.8| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 1 3.0| Hyperkeratosis | 3 | 1 3.0| Inflammation, Chronic Active | 4 2 2 3 3 | 6 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 4 2 2 | 6 2.3| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 3 3 1 3 3 2| 27 2.1| Inflammation, Chronic Active | 3 | 1 3.0| Atrium, Thrombosis | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| | | 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 2 2 2 2 2 2 2 2 | 15 2.0| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | 23 1.8| Hypertrophy | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1 2 | 10 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + M + + + M + + + M + M + + + + M + + + + +| 42 | Hyperplasia | 3 2| 2 2.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Atypia Cellular | | 2 | Pars Distalis, Cyst | X X X X X X X X X X X X| 25 | Pars Distalis, Hyperplasia | 3 2 2 2 2 | 11 2.3| Pars Intermedia, Cyst | X X | 3 | Pars Nervosa, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 2 2 2 2 2 3 2 2 2 3 2| 27 2.1| Follicular Cell, Hyperplasia | 3 4 3 2 3 2 3 3 3 3 3 1 3 3 3 3 3 4 3 3 3 4 3| 47 2.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 2 3 2 | 8 2.3| Duct, Dilatation | 4 4 | 9 2.4| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Cyst | X X X X X X X X | 16 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cervix, Diverticulum | | 1 4.0| Cervix, Inflammation, Suppurative | | 1 3.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 3 | 8 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| | | 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lumbar, Inflammation, Chronic Active | | 1 4.0| Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0| Mandibular, Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3| 2 3.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + M + + M + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 4 3 2 3 4 2 3 3 4 2 4 2 4 2 3 2 3 3 2 3 3 3 4 2| 49 2.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 1 | Femur, Fibrous Osteodystrophy | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X X X X X | 13 | Hemorrhage | 3 | 1 3.0| Hydrocephalus | 2 2 3 3 3 4 | 11 2.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X | 1 | Inflammation, Chronic Active | 1 1 4 3 1| 10 2.1| Alveolar Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X X | 2 | Inflammation, Chronic Active | 3 3 4 1 | 6 2.3| Mucosa, Nasolacrimal Duct, | | | Hyperplasia | 4| 1 4.0| Nasolacrimal Duct, Dilatation | 4| 1 4.0| Nasolacrimal Duct, Hyperkeratosis | 4| 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| | | 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 3 2 2 | 5 2.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + | 8 | Lens, Cataract | 4 2 4 3 | 5 3.4| Retina, Atrophy | 4 4 4 4 | 5 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Inflammation, Chronic Active | | 1 4.0| Necrosis, Coagulative | 4 | 1 4.0| Nephropathy, Chronic | 3 4 2 3 1 2 2 2 2 2 2 3 4 2 2 3 2 1 2 3 2 3 2| 47 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3| DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0| | 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| Parasite Metazoan | X X X X | Artery, Necrosis, Fibrinoid | 2 | Perivascular, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Clear Cell Focus | | Degeneration, Cystic | 1 2 2 3 2 | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X| Inflammation, Chronic | 1 | Necrosis, Coagulative | 3 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic Active | 4 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| Cyst | | Acinus, Atrophy | 2 3 1 2 2 2 2 2 | Acinus, Hyperplasia | | Artery, Necrosis, Fibrinoid | 2 | Perivascular, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 2 | Hyperkeratosis | 3 2 | Hyperplasia, Squamous | 2 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3| DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0| | 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 3 | Necrosis, Coagulative | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 3 3 3 3 2 2 1 3 2 2 3 3 2 2 2 3 3 2 2 2 3 2| Inflammation, Chronic Active | 2 | Mineralization | 2 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 1 2 2 | Hyperplasia | 2 3 3 2 2 2 2 | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + M + M + + M + + + + + + + + +| Hyperplasia | 3 2 3 4 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 1 2 2 2 2 2 1 2 2 1 2 1 2 2 2 | Follicle, Cyst | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 1 1 1 1 2 2 3 2 1 3 2 4 | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3| DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0| | 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis, Coagulative | | Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 | Seminiferous Tubule, Atrophy | 3 3 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | 2 | Femoral, Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Cyst | X | Mandibular, Hyperplasia, Plasma Cell | 2 3 | Mediastinal, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | M + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Hematopoietic Cell Proliferation | | Thrombosis | | __________________________________________________________________________| Thymus | + M + + + + M + M + + + + + M + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + M + + M + + + + M M + + + + +| Hyperplasia, Cystic | 2 2 2 1 1 4 2 2 1 1 2 3 2 3 2 2 2 2 1 2 1| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X X X | Femur, Fibrous Osteodystrophy | X X X X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | Hemorrhage | 2 | Hydrocephalus | 2 | Necrosis | 3 | __________________________________________________________________________| Peripheral Nerve | + + | __________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3| DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0| | 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Hemorrhage | 4 | White Matter, Degeneration | 3 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | 2 | Hemorrhage | 4 | Inflammation, Chronic Active | 1 2 2 | Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | X | Inflammation, Chronic Active | 1 4 1 1 1 2| Nasolacrimal Duct, Inflammation, | | Suppurative | 1 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + + + | Hemorrhage | | Inflammation, Chronic Active | | Lens, Cataract | 4 4 3 4 4 | Retina, Atrophy | 4 4 4 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + I + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Nephropathy, Chronic | 3 3 2 3 4 4 2 2 3 2 3 3 3 3 2 2 4 2 4 4 3 2 3 4 | Artery, Necrosis, Fibrinoid | 2 | Perivascular, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Urethra | + | Transitional Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | Hemorrhage | 3 | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| | | 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + A + + + + +| 45 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + A + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X X | 7 | Artery, Necrosis, Fibrinoid | | 1 2.0| Perivascular, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + M A + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X| 12 | Clear Cell Focus | X | 1 | Degeneration, Cystic | 1 1 2 1 2 2 2 1 2 1 1 1 | 17 1.6| Hematopoietic Cell Proliferation | 3 | 1 3.0| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Chronic | 2 | 2 1.5| Necrosis, Coagulative | 3 | 2 3.0| Vacuolization Cytoplasmic | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Inflammation, Chronic Active | 3 | 3 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | Cyst | X | 1 | Acinus, Atrophy | 2 1 1 1 1 1 2 1 1 3 2 2 | 20 1.7| Acinus, Hyperplasia | 2 | 1 2.0| Artery, Necrosis, Fibrinoid | | 1 2.0| Perivascular, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 3 3 | 4 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| | | 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | 3 3 | 4 2.8| Hyperplasia, Squamous | | 1 2.0| Inflammation, Chronic Active | 2 4 | 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| Mineralization | 2 | 2 2.5| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 3 2 3 2 2 3 3 3 3 3 2 2 3 3 2 2 2 2 3 2 2| 46 2.4| Inflammation, Chronic Active | | 1 2.0| Mineralization | 2 | 2 2.0| Atrium, Thrombosis | X X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 2 1 4 1 2 2 1 2 | 14 1.9| Hyperplasia | 2 2 2 2 2 2 2 2 | 15 2.1| Hypertrophy | 2 1 1 | 4 1.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2| 21 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 44 | Hyperplasia | 4 2 3 | 8 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X X X | 4 | Pars Distalis, Hyperplasia | 2 2 2 2 | 12 1.9| Pars Intermedia, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 2 2 1 1 1 2 2 2 2 2 3 1| 29 1.8| Follicle, Cyst | X | 1 | Follicular Cell, Hyperplasia | 2 1 1 1 | 4 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| | | 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2| 3 2.0| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 45 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2 2 2 3 1 1 1 3 3 3 1 2 2| 29 2.0| __________________________________________________________________________|____________| Seminal Vesicle | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 1 4.0| Necrosis, Coagulative | 4 | 1 4.0| Interstitial Cell, Hyperplasia | 1 1 | 9 1.1| Seminiferous Tubule, Atrophy | 4 3 4 3 3 3 | 9 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + | 17 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | | 1 2.0| Femoral, Myeloid Cell, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Cyst | | 1 | Mandibular, Hyperplasia, Plasma Cell | | 2 2.5| Mediastinal, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 2 4 2 | 6 2.5| Hematopoietic Cell Proliferation | 3 | 1 3.0| Thrombosis | X | 1 | __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + M + + M + M M + + +| 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| 42 | Hyperplasia, Cystic | 3 2 2 2 1 2 1 4 3 3 1 2 1 4 2 1 2 1 1 1 1| 42 1.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| | | 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | | 4 | Femur, Fibrous Osteodystrophy | | 4 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X | 5 | Hemorrhage | | 1 2.0| Hydrocephalus | 3 3 2 | 4 2.5| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 2 | Hemorrhage | | 1 4.0| White Matter, Degeneration | | 2 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma | | 1 2.0| Hemorrhage | | 1 4.0| Inflammation, Chronic Active | 2 1 3 2 2 1 | 9 1.8| Mineralization | | 1 3.0| Alveolar Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X X X X | 5 | Inflammation, Chronic Active | 4 3 3 3 1 1 3 1 2 | 15 2.1| Nasolacrimal Duct, Inflammation, | | | Suppurative | 1 3 1 | 6 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + | 11 | Hemorrhage | 4 | 1 4.0| Inflammation, Chronic Active | 2 | 1 2.0| Lens, Cataract | 4 3 4 3 | 9 3.7| Retina, Atrophy | 4 3 4 4 | 10 3.9| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| | | 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | | 1 3.0| Nephropathy, Chronic | 2 3 3 2 2 3 3 3 4 3 3 4 2 3 4 4 4 1 3 2 2 2 4 3 3| 49 2.9| Artery, Necrosis, Fibrinoid | | 1 2.0| Perivascular, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Urethra | | 1 | Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | Dilatation | | 1 4.0| Hemorrhage | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4| | 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Perivascular, Inflammation, Chronic | | Active | 2 2 2 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Degeneration, Cystic | 1 2 3 1 3 3 3 1 3 2 3 | Eosinophilic Focus | | Inflammation, Chronic | | Necrosis, Coagulative | 2 3 | Vacuolization Cytoplasmic | 3 | Bile Duct, Hyperplasia | 3 3 3 | __________________________________________________________________________| Mesentery | + + + + | Inflammation, Chronic Active | 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | 2 2 3 3 2 1 3 2 2 1 1 3 3 2 2 1 1| Perivascular, Inflammation, Chronic | | Active | 2 4 | __________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 | Mineralization | 3 3 3 2| __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 2 3 2 2 3 2| _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4| | 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic Active | | Atrium, Thrombosis | X X X X X X X | Ventricle, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 2 3 2 2 | Hyperplasia | 2 2 1 1 1 2 1 2 3| Hypertrophy | 3 | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 | Necrosis, Coagulative | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + M M + + + + + + M + + + + +| Hyperplasia | 3 3 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 | Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 1 2 2 2 2| Pars Distalis, Vacuolization | | Cytoplasmic | | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 2 2 1 1 2 1 1 2 1 3 2 1 2 1 1 2| Follicular Cell, Hyperplasia | 1 1 1 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Perivascular, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | | Inflammation, Chronic | | Inflammation, Chronic Active | 3 2 3 2 2 2 2 2 4 2 2 2 2 4 3 2 2 3 2 2 1 2| Duct, Dilatation | | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4| | 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 3 2 2 4 2 4 3| __________________________________________________________________________| Seminal Vesicle | + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 2 1 1 1 | Seminiferous Tubule, Atrophy | 3 3 3 3 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | | Femoral, Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Cyst | | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Necrosis | | Mediastinal, Cyst | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + +| Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 3 2 | Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | M + + + + M M + + + + M + + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + M + + + + + M + + + + M + +| Hyperplasia, Cystic | 2 2 2 2 2 1 2 1 2 4 3 4 1 1 1 2 2 2 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| Acanthosis | | Hyperkeratosis | | Subcutaneous Tissue, Fibrosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X X | Femur, Fibrous Osteodystrophy | X X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hemorrhage | | Hydrocephalus | 2 2 | Necrosis | 4 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4| | 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 1 | Alveolar Epithelium, Hyperplasia | | Mediastinum, Perivascular, | | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation, Chronic Active | 2 2 1 1 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 3 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + +| Lens, Cataract | 4 4 4 4 4| Retina, Atrophy | 4 4 4 4 4| __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Nephropathy, Chronic | 3 3 3 2 2 3 4 2 4 1 3 3 3 3 3 4 4 4 3 2 4 3 3 1 3| Renal Tubule, Epithelium, Hyperplasia| 4 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| | | 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 | Inflammation, Chronic Active | | 1 3.0| Perivascular, Inflammation, Chronic | | | Active | 3 | 5 2.2| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + + M + + + + + + + + + + + A +| 46 | Inflammation, Chronic Active | 4 | 1 4.0| Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 4 | Clear Cell Focus | | 2 | Degeneration, Cystic | 1 2 3 4 2 3 2 2| 19 2.3| Eosinophilic Focus | X | 1 | Inflammation, Chronic | 3 1 2 | 3 2.0| Necrosis, Coagulative | 3 3 | 4 2.8| Vacuolization Cytoplasmic | | 1 3.0| Bile Duct, Hyperplasia | 3| 4 3.0| __________________________________________________________________________|____________| Mesentery | + | 5 | Inflammation, Chronic Active | | 2 3.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| Acinus, Atrophy | 2 1 1 3 2 2 4 3 2 2 2 1 1| 30 2.0| Perivascular, Inflammation, Chronic | | | Active | 2 | 3 2.7| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 4 | 4 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 2.5| Mineralization | | 4 2.8| __________________________________________________________________________|____________| Tongue | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| | | 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 2 2 2 1 3 2 3 2 2 2 2 3 2 2 2 2 3 2 2 3 3 | 44 2.3| Inflammation, Chronic Active | 3 | 1 3.0| Atrium, Thrombosis | X | 8 | Ventricle, Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 2 2 2 1 3 2 2 2 | 15 2.1| Hyperplasia | 2 2 2 2 3 2 3 2 1 | 18 1.9| Hypertrophy | 2 | 2 2.5| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 1 2 2 2 3 2 2| 21 2.0| Necrosis, Coagulative | | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 3 | 5 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | | 1 3.0| Pars Distalis, Cyst | X X | 3 | Pars Distalis, Hyperplasia | 1 2 2 1 | 9 1.7| Pars Distalis, Vacuolization | | | Cytoplasmic | 2 | 1 2.0| Pars Intermedia, Cyst | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Inflammation, Chronic Active | | 1 3.0| Ultimobranchial Cyst | X X | 3 | C-Cell, Hyperplasia | 1 1 2 2 1 1 2 2 2 2 1 2 2 2 2 2| 33 1.6| Follicular Cell, Hyperplasia | 1 2 1 1 2 2 | 12 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| | | 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + | 3 | Inflammation, Chronic Active | 4 | 2 3.5| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perivascular, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 2 2 3 4 2 2 3 2 3 2 2 2 2 2 4| 45 2.3| Duct, Dilatation | 4| 1 4.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 1 1 2 2 2 3 2 2 4 2 1 3 3 4| 27 2.4| __________________________________________________________________________|____________| Seminal Vesicle | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 | 12 1.2| Seminiferous Tubule, Atrophy | 3 4 3| 8 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + +| 25 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Reticulum Cell | 2 | 1 2.0| Femoral, Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Cyst | X X | 2 | Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0| Mandibular, Necrosis | 3 | 1 3.0| Mediastinal, Cyst | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 10 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 3 2 4 3 | 8 2.8| Hematopoietic Cell Proliferation | 3 3 3 | 3 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + M + M + + M + M + + + + + + + M + M| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + M M + + + M + + + M + + + M + + + + +| 40 | Hyperplasia, Cystic | 4 2 2 1 2 1 3 1 1 2 4 3 2 4 2 2 2| 36 2.1| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| | | 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | 2 | 1 2.0| Subcutaneous Tissue, Fibrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 4 | Femur, Fibrous Osteodystrophy | X | 4 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X | 5 | Hemorrhage | 4 4 | 2 4.0| Hydrocephalus | 3 2 2 | 5 2.2| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 4 1.8| Alveolar Epithelium, Hyperplasia | 4 | 1 4.0| Mediastinum, Perivascular, | | | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Inflammation, Chronic Active | 1 2 2 1 2 | 10 1.6| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 4 | 4 2.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + | 10 | Lens, Cataract | 2 4 | 7 3.7| Retina, Atrophy | 4 4 4 4 | 9 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 3 | 1 3.0| Nephropathy, Chronic | 2 3 3 3 2 3 3 3 2 3 3 2 3 3 4 4 4 2 3 4 3 3 3 3 3| 50 2.9| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| | | 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Epithelium, Hyperplasia| 4 4 | 3 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4| | 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + A A + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A A + + + + + + A + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | + + + + + A A + + + M + + A + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A A + + + + + + A + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A A + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Degeneration, Cystic | 3 2 2 2 2 4 1 2 2| Hyperplasia | 3 | Inflammation, Chronic | 2 1 1 1 | Necrosis, Coagulative | | Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Mesentery | + + +| Hemorrhage | 4 | Inflammation, Chronic Active | 3 4| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Acinus, Atrophy | 2 1 4 1 2 2 2 2 1 1 2 2 1 1| Acinus, Hyperplasia, Focal | | Perivascular, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 | Hyperkeratosis | 2 2 | Inflammation, Chronic Active | 2 2| __________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 3 | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 3 2 2 2 1 2 2 2 3 3 2 3 2 3 2 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4| | 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Mineralization | 2 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 1 2 2 1 2 2 2 | Hyperplasia | 3 2 2 4 2 2 2 2 2 3| Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 1 3 2 2 3 2 3 2 2 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | 3 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 2 3 2| Pars Intermedia, Cyst | | Rathke's Cleft, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + A + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 2 1 2 2 2 2 1 1| Follicular Cell, Hyperplasia | 1 2 1 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 4 | Inflammation, Chronic Active | 2 2 2 2 2 4 3 4 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1| Duct, Dilatation | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Inflammation, Chronic Active | 1 1 1 2 2 2 1 2 1 1 1 1| __________________________________________________________________________| Seminal Vesicle | + | Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Interstitial Cell, Hyperplasia | 1 1 1 2 | Seminiferous Tubule, Atrophy | 3 3 3 2 4 3 2 3 4 4| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4| | 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Cyst | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + A + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | 4 | __________________________________________________________________________| Thymus | + + + + M + + + + + + I + M + + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M + M + + + M + + + + + + + + + + + + + M +| Hyperplasia, Cystic | 1 1 4 4 2 2 3 2 4 2 1 3 2 3 1 2 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X | Femur, Fibrous Osteodystrophy | X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | Hemorrhage | 4 | Hydrocephalus | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1| Metaplasia, Osseous | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Chronic Active | 2 1 1 2 1 1 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + | Lens, Cataract | 3 3 3 | Retina, Atrophy | 4 4 4 | _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4| | 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | | Inflammation, Chronic Active | | Nephropathy, Chronic | 3 3 3 4 2 1 2 3 2 2 2 3 1 4 2 3 2 2 3 4 2 2 2 3 3| Renal Tubule, Mineralization | | Renal Tubule, Epithelium, Hyperplasia| 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| | DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| | | 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + A + + + + + A + A + + + + + + + + A| 43 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + A + A + A M A + + + + A| 40 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + A + A + + + + + + + + A| 42 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + + + + + A + A + + + A + M A + A| 40 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + A + + + + + + + A + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + A + + + + + + + + A| 46 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + A + M + + + + + + A + A| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + A + + + + + + A + A| 44 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X | 9 | Degeneration, Cystic | 1 4 1 1 1 1 1 1 3 | 18 1.9| Hyperplasia | | 1 3.0| Inflammation, Chronic | 1 2 1 | 7 1.3| Necrosis, Coagulative | 2 2 2 | 3 2.0| Vacuolization Cytoplasmic | 2 | 2 2.5| __________________________________________________________________________|____________| Mesentery | + + + | 6 | Hemorrhage | | 1 4.0| Inflammation, Chronic Active | 3 4 | 4 3.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Acinus, Atrophy | 1 1 1 2 1 2 2 1 1 2 | 24 1.6| Acinus, Hyperplasia, Focal | 3 | 1 3.0| Perivascular, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 | Acanthosis | 2 | 3 2.0| Hyperkeratosis | 1 | 3 1.7| Inflammation, Chronic Active | 2 | 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 | Inflammation, Chronic Active | 1 2 | 3 1.7| Mineralization | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 88 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| | DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| | | 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 3 3 2 2 2 1 2 2 3 2 2 2 2 1 2 3 1 2 2 2 3 2 3| 47 2.1| Mineralization | | 1 2.0| Atrium, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | 2 2 1 1 | 11 1.6| Hyperplasia | 2 2 2 2 3 2 2 2 1 | 19 2.2| Hypertrophy | 2 2 2 1 | 5 1.8| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 2 1 2 2 2 2 2 1 2 | 23 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 | Hyperplasia | 4 | 3 3.7| __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Pars Distalis, Cyst | X X X X | 4 | Pars Distalis, Hyperplasia | 1 2 2 2 2 2 2 | 12 2.0| Pars Intermedia, Cyst | X X X | 3 | Rathke's Cleft, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + A + A + + + + + + + + +| 46 | C-Cell, Hyperplasia | 2 1 2 2 3 2 2 1 1 1 1 | 22 1.6| Follicular Cell, Hyperplasia | 1 2 1 2 1 2 | 13 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 4.0| Inflammation, Chronic Active | 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2| 46 2.0| Duct, Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 89 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| | DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| | | 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cyst | | 1 | Inflammation, Chronic Active | 1 2 1 3 1 3 2 2 1 1 4 | 23 1.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + | 4 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 | 9 1.1| Seminiferous Tubule, Atrophy | 3 | 11 3.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + | 24 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Cyst | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 14 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 2 2.0| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis, Coagulative | 4 | 2 4.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + M + +| 42 | Hyperplasia, Cystic | 3 2 1 3 2 2 1 1 1 3 3 2 2 1 1 1 2 1 1 2 1 | 39 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 2 3.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 3 | Femur, Fibrous Osteodystrophy | X | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 1 | Hemorrhage | | 1 4.0| Hydrocephalus | 4 | 2 3.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 90 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| | DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| | | 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 2 3| 5 1.6| Metaplasia, Osseous | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X | 1 | Inflammation, Chronic Active | 3 2 3 2 1| 12 1.8| Nasolacrimal Duct, Inflammation, | | | Suppurative | 4 1 3 3 1 | 7 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 6 | Lens, Cataract | 3 | 4 3.0| Retina, Atrophy | 4 | 4 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 | Bacterium | X | 1 | Inflammation, Chronic Active | 2 | 1 2.0| Nephropathy, Chronic | 2 3 3 2 2 3 2 1 4 2 3 3 3 2 2 2 3 3 3 3 2 2| 47 2.5| Renal Tubule, Mineralization | 2 | 1 2.0| Renal Tubule, Epithelium, Hyperplasia| | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 91 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6| DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1| | 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + A + + + A| Inflammation, Chronic Active | | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| Necrosis, Coagulative | | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + M + + + A| Parasite Metazoan | X X X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A| Necrosis, Coagulative | 4 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A| Dilatation | 4 | Inflammation, Chronic Active | 4 | Metaplasia, Osseous | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X | Clear Cell Focus | X | Degeneration, Cystic | 2 2 2 3 1 3 1 2 2 | Hepatodiaphragmatic Nodule, Multiple | X | Inflammation, Chronic | 2 1 | Leukocytosis | X | Necrosis, Coagulative | 2 3 | Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 1 2 2 4 2 2 4 2 1 | Perivascular, Inflammation, Chronic | | Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Hyperkeratosis | 3 | Hyperplasia | | Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | 1 3 3 | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6| DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1| | 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 2 2 2 2 2 3 3 2 2 3 2 3 1 2 2 3| Inflammation, Chronic Active | 3| Mineralization | | Atrium, Thrombosis | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 1 2 1 1 2 1 1 | Hyperplasia | 1 2 2 2 2 3 3 2| Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 2 2 2 2 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + I + + + + + + + + + + M M + + +| Hyperplasia | 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X | Pars Distalis, Hemorrhage | 3 4 | Pars Distalis, Hyperplasia | 2 3 2 2 2 2 | Pars Intermedia, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + A| C-Cell, Hyperplasia | 2 3 2 1 2 2 2 1 3 2 1 1 1 2 2 2 2 | Follicular Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Inflammation, Chronic Active | 2 1 1 2 3 3 4 1 3 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Seminal Vesicle | | Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6| DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1| | 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Hyperplasia | 1 1 1 1 | Seminiferous Tubule, Atrophy | 3 3 3 3 4 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | | Femoral, Myelofibrosis | 3| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | 2 | Mandibular, Hyperplasia, Plasma Cell | | Mediastinal, Inflammation, | | Suppurative | | Renal, Infiltration Cellular, | | Histiocyte | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 2 | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + M +| Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M M + + M + + + M + + + + M + M + + + M +| Hyperplasia, Cystic | 1 1 2 1 1 2 2 3 2 1 2 1 2 2 1 2 1 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperplasia, Basal Cell | 3 | Vein, Dilatation | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hemorrhage | 3 2 | Hydrocephalus | 3 2 | __________________________________________________________________________| Peripheral Nerve | | Sciatic, Degeneration | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| Page 94 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6| DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1| | 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | White Matter, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 | Leukocytosis | X | Necrosis, Coagulative | 3 | Alveolar Epithelium, Hyperplasia | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Fungus | X X X X X | Inflammation, Chronic Active | 2 2 3 4 3 2 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 4 1 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + + + + +| Lens, Cataract | 3 3 4 2| Retina, Atrophy | 4 4 4 4| __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 4 4| Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 3 3 4 1 4 3 2 3 2 3 4 1 2 1 4 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 95 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| | DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| | | 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + A + A + + + A| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + A + + + A| 44 | Inflammation, Chronic Active | 2 2 | 2 2.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A + A + + + A| 45 | Necrosis, Coagulative | 4 | 1 4.0| Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + A + A + + + A| 43 | Parasite Metazoan | X X X X | 9 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + M A + + + + + + A + A + + + A| 43 | Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + A| 46 | Dilatation | | 1 4.0| Inflammation, Chronic Active | | 1 4.0| Metaplasia, Osseous | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 7 | Clear Cell Focus | X | 2 | Degeneration, Cystic | 2 2 2 1 | 13 1.9| Hepatodiaphragmatic Nodule, Multiple | | 1 | Inflammation, Chronic | 1 | 3 1.3| Leukocytosis | | 1 | Necrosis, Coagulative | 3 4 | 4 3.0| Bile Duct, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 2 1 3 1 2 2 1 2 2 3 1 | 24 1.9| Perivascular, Inflammation, Chronic | | | Active | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 2 3.0| Hyperkeratosis | 3 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| | DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| | | 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperplasia | 4 | 1 4.0| Inflammation, Chronic Active | 4 2 2 | 5 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic Active | 3 | 4 2.5| Mineralization | 2 4 | 2 3.0| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 1 2 3 3 2 2 1 2 3 3 2 3 2 2 4 2 2| 41 2.3| Inflammation, Chronic Active | | 1 3.0| Mineralization | 3 3 | 2 3.0| Atrium, Thrombosis | X X X X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 1 1 2 2 1 1 2 1 | 15 1.3| Hyperplasia | 2 2 2 2 1 3 1 2 2 | 17 2.0| Hypertrophy | 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | 1 2 2 1 2 2 2 2 2 2 | 21 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 45 | Hyperplasia | 4 4 | 4 3.5| __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + + + + + + M + + + + A + + + +| 47 | Pars Distalis, Cyst | X X | 4 | Pars Distalis, Hemorrhage | | 2 3.5| Pars Distalis, Hyperplasia | 2 1 1 | 9 1.9| Pars Intermedia, Cyst | X X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + A| 46 | C-Cell, Hyperplasia | 2 1 2 2 2 2 1 2 1 2 2 1 2 | 30 1.8| Follicular Cell, Hyperplasia | 3 2 2 2 1 2 2 1 2 2 2 2 2 3 | 30 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| | DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| | | 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 3 | Inflammation, Chronic Active | 2 2 1 2 4 2 3 2 2 2 2 1 2 4 4| 24 2.3| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | +| 1 | Inflammation, Chronic Active | 4| 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 1 1 | 7 1.1| Seminiferous Tubule, Atrophy | 3 3 4 3 3 | 11 3.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + | 21 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Reticulum Cell | 1 | 1 1.0| Femoral, Myelofibrosis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Hyperplasia, Lymphoid | | 1 2.0| Mandibular, Hyperplasia, Plasma Cell | 3 | 1 3.0| Mediastinal, Inflammation, | | | Suppurative | 4 | 1 4.0| Renal, Infiltration Cellular, | | | Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 4 2.8| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis, Coagulative | 4 | 1 4.0| __________________________________________________________________________|____________| Thymus | M + + + M M + + + + + + + + + + M + + + + + + M M| 42 | Cyst | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + M + M + M + + + + M + + M M| 37 | Hyperplasia, Cystic | 1 2 1 2 1 3 1 3 4 2 2 3 2 2 2 2 4 | 35 1.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 1 3.0| Hyperplasia, Basal Cell | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| | DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| | | 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Vein, Dilatation | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 1 | Femur, Fibrous Osteodystrophy | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X | 5 | Hemorrhage | 3 | 3 2.7| Hydrocephalus | 3 4 3 | 5 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | Sciatic, Degeneration | 2 | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | + | 1 | White Matter, Degeneration | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 2 | 5 1.2| Leukocytosis | | 1 | Necrosis, Coagulative | | 1 3.0| Alveolar Epithelium, Hyperplasia | 3 | 2 3.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Fungus | | 5 | Inflammation, Chronic Active | 2 1 2 2 | 11 2.2| Nasolacrimal Duct, Inflammation, | | | Suppurative | | 5 2.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 2 | __________________________________________________________________________|____________| Eye | + + | 8 | Lens, Cataract | 4 2 | 6 3.0| Retina, Atrophy | 4 4 | 6 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Zymbal's Gland | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| | DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| | | 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | | 2 4.0| Nephropathy, Chronic | 4 2 2 4 2 3 3 3 3 3 2 2 3 3 1 2 4 2 4 2 4 3 3 4 | 49 2.6| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7| DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4| | 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + A + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + + + + A + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + A + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + M + A + + + + + + + A + + +| Edema | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + A + + + + + + + + A + + + + + + + + + + +| Edema | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| Edema | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X| Clear Cell Focus | X X | Cyst | | Degeneration, Cystic | 2 1 1 1 1 2 1 2 2 1 2 1 1| Inflammation, Chronic | 1 | Leukocytosis | | Vacuolization Cytoplasmic | | Bile Duct, Hyperplasia | 3 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | Thrombosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 3 1 3 1 2 2 1 2 2 2 1 2| Acinus, Hyperplasia, Focal | 3 | Perivascular, Inflammation, Chronic | | Active | 4 3 3 4 | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 3 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| Page 101 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7| DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4| | 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 3 3 2 2 2 2 3 2 2 3 2 3 2 2 2 2 2 3 2 2 2| Mineralization | 2 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 1 1 2 1 1 2 | Hyperplasia | 1 1 2 2 2 2 2 2 1 2 2| Hypertrophy | 2 1 | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 1 2 2 1 2 1 2 2 2 2 2 3| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + M + + + +| Hyperplasia | 3 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X | Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia | 2 2 2 2 2| Pars Intermedia, Cyst | X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 2 1| Follicular Cell, Hyperplasia | 2 1 2 2 2 2 2 3 3 1 1 2 3 3 3 3 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + M + + + + + + M + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 1 2 2 1 2 2 1 3 3 2 2 2 2 2 2 2 1 2 1 2| Duct, Dilatation | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 1 2 1 2 2 2 2 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 | Seminiferous Tubule, Atrophy | 3 3 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 102 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7| DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4| | 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Necrosis | 4 | Mandibular, Cyst | X | Mandibular, Necrosis | 4 | Mediastinal, Cyst | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Necrosis, Coagulative | 4 | Thrombosis | X X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + M + + + + + M + + + +| Necrosis | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + + + + + M + M + + + + + + + +| Hyperplasia, Cystic | 3 2 1 2 2 2 2 3 4 2 2 1 2 2 1 2 2 1 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X | Femur, Fibrous Osteodystrophy | X X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | Hemorrhage | 3 | Hydrocephalus | 3 | __________________________________________________________________________| Peripheral Nerve | M | __________________________________________________________________________| Spinal Cord | + | White Matter, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 1 1 2 | Metaplasia, Osseous | 1 | _____________________________________________________________________________________________________________________| Page 103 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7| DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4| | 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia | 2 2 | Artery, Mediastinum, Necrosis, | | Fibrinoid | 3 | Mediastinum, Perivascular, | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 4 2 2 3 2 1 | Nasolacrimal Duct, Hyperkeratosis | 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Lens, Cataract | 4 | Retina, Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mixed Cell | | Inflammation, Chronic Active | | Nephropathy, Chronic | 4 4 2 3 2 3 3 4 2 2 2 2 2 2 3 3 3 4 4 2 3 3 3 4 4| Renal Tubule, Hyperplasia | 4 | __________________________________________________________________________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 104 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| | DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| | | 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + A + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + A + + + + + A + + + + + A + +| 43 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + A + + + M + + + + + + + + + +| 45 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + A + + + + + + + + + + + + + +| 44 | Edema | 3 | 1 3.0| Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + M + + + + + + + + + +| 45 | Edema | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + M + + + + + + + + + +| 47 | Edema | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X | 14 | Clear Cell Focus | | 2 | Cyst | X | 1 | Degeneration, Cystic | 1 3 1 2 2 2 4 | 20 1.7| Inflammation, Chronic | | 1 1.0| Leukocytosis | X | 1 | Vacuolization Cytoplasmic | 2 3 | 2 2.5| Bile Duct, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 2 | Inflammation, Chronic Active | 2 | 1 2.0| Thrombosis | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 2 2 1 2 2 2 1 3 3 3 1 3 1 3 2| 27 2.0| Acinus, Hyperplasia, Focal | | 1 3.0| Perivascular, Inflammation, Chronic | | | Active | 4 | 5 3.6| __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + A + + + + + + + M + + + + + + + + + + + +| 48 | Acanthosis | 2 2 2 3 | 4 2.3| Hyperkeratosis | 2 3 2 2 | 4 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 105 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| | DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| | | 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 4 3 4 4 2 2 | 6 3.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 4 2 3 2 2 | 6 2.5| Mineralization | 3 | 2 3.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 3 2 2 1 2 1 2 3 2 2 2 2 3 3 2 2 2 2 2 2 2| 44 2.2| Mineralization | | 1 2.0| Atrium, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | 3 1 2 1 2 2 2 | 13 1.6| Hyperplasia | 3 2 1 2 2 2 2 3 2 2 | 21 1.9| Hypertrophy | 2 3 2 | 5 2.0| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 2 2 2 2 2 2 2 2 1 2 2 1 2 2| 30 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + + + + +| 45 | Hyperplasia | 3 3 3 | 6 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | X X X | 7 | Pars Distalis, Hemorrhage | 4 4 3 | 4 3.8| Pars Distalis, Hyperplasia | 2 2 2 2 2 | 10 2.0| Pars Intermedia, Cyst | X X | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + A + + + + + A + + + + + + + + + + + + + +| 47 | C-Cell, Hyperplasia | 2 2 2 2 1 2 2 1 3 2 2 2 2 2 2 1 3| 35 1.9| Follicular Cell, Hyperplasia | 3 2 3 2 2 1 2 2 3 2 1 1 3 3 2 2 1| 35 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 106 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| | DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| | | 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + A + + M + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2| 42 2.0| Duct, Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 4 1 2 2 1 1 2 2 4 3 | 21 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 1 1 1 | 4 1.0| Seminiferous Tubule, Atrophy | 4 3 3 4 4 | 8 3.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + | 24 | __________________________________________________________________________|____________| Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Femoral, Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Inguinal, Necrosis | | 1 4.0| Mandibular, Cyst | X X | 3 | Mandibular, Necrosis | | 1 4.0| Mediastinal, Cyst | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | A + + + + | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 2 | 3 2.7| Necrosis, Coagulative | | 1 4.0| Thrombosis | | 2 | __________________________________________________________________________|____________| Thymus | + + + M A + M + + M + + + + + + M + + + + + + M M| 40 | Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + M + +| 45 | Hyperplasia, Cystic | 2 1 2 2 2 2 2 3 2 2 4 1 2 1 1 1 2 4 1 2 2| 40 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Abscess | | 1 4.0| Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X X X X | 6 | Femur, Fibrous Osteodystrophy | X X X X | 6 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 107 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| | DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| | | 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X | 3 | Hemorrhage | 2 2 | 3 2.3| Hydrocephalus | 2 2 | 3 2.3| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | White Matter, Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 5 1.4| Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| Artery, Mediastinum, Necrosis, | | | Fibrinoid | | 1 3.0| Mediastinum, Perivascular, | | | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 2 3 2 3 1| 13 2.2| Nasolacrimal Duct, Hyperkeratosis | | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 1 2 3 1 2 | 8 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + | 4 | Lens, Cataract | 4 3 | 3 3.7| Retina, Atrophy | 4 4 | 3 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mixed Cell | 3 | 1 3.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 108 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| | DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| | | 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy, Chronic | 4 2 3 2 3 3 2 2 3 3 3 2 2 3 3 4 3 3 3 4 4 3 3 2| 49 2.9| Renal Tubule, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 109 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 5| 5| 7| 3| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 6| DAY ON TEST | 0| 3| 5| 5| 3| 7| 4| 0| 8| 3| 0| 7| 1| 4| 4| 1| 4| 4| 4| 9| 4| 7| 0| 0| 4| | 7| 8| 2| 2| 8| 1| 7| 9| 7| 8| 1| 8| 3| 1| 1| 5| 1| 2| 0| 3| 1| 8| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + A + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + A + + M +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | | Degeneration, Cystic | 2 2 4 1 4 3 4 2 1 2 2 | Hyperplasia | | Inflammation, Chronic | 2 | Necrosis, Coagulative | 1 3 4 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Inflammation, Chronic Active | 2 | Acinus, Atrophy | 2 2 1 2 2 4 1 2 1| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 | Hyperkeratosis | 2 2 | Hyperplasia, Squamous | 3 | Inflammation, Chronic Active | 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 2 | Necrosis, Coagulative | 3 | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 3 2 3 2 2 2 3 4 2 3 2 3 3 2 2 3 2 3 2 2 2 | Mineralization | 3 2 | Atrium, Thrombosis | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 110 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 5| 5| 7| 3| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 6| DAY ON TEST | 0| 3| 5| 5| 3| 7| 4| 0| 8| 3| 0| 7| 1| 4| 4| 1| 4| 4| 4| 9| 4| 7| 0| 0| 4| | 7| 8| 2| 2| 8| 1| 7| 9| 7| 8| 1| 8| 3| 1| 1| 5| 1| 2| 0| 3| 1| 8| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Degeneration, Fatty | 2 1 1 2 3 1 1 | Hyperplasia | 3 2 2 2 2 2 2 2 2 | Hypertrophy | 2 2 2 3 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematocyst | | Hyperplasia | 1 3 3 2 2 3 3 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + + + + + + + + M + + + + + + + +| Hyperplasia | 4 4 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 1 | Pars Intermedia, Cyst | X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1| Follicular Cell, Hyperplasia | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 4 2 3 2 2 2 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | | Inflammation, Chronic Active | 2 1 2 2 2 2 2 2 2 2 2 2 3 4 2 2 2 2 3 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +| Cyst | | Inflammation, Chronic Active | 1 1 2 1 2 2 2 2 2 2 2 2 2 2| Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | | Interstitial Cell, Hyperplasia | 2 2 | Seminiferous Tubule, Atrophy | 4 3 4 4 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myeloid Cell, Atrophy | | _____________________________________________________________________________________________________________________| Page 111 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 5| 5| 7| 3| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 6| DAY ON TEST | 0| 3| 5| 5| 3| 7| 4| 0| 8| 3| 0| 7| 1| 4| 4| 1| 4| 4| 4| 9| 4| 7| 0| 0| 4| | 7| 8| 2| 2| 8| 1| 7| 9| 7| 8| 1| 8| 3| 1| 1| 5| 1| 2| 0| 3| 1| 8| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Cyst | X| Mandibular, Hyperplasia, Plasma Cell | 3| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | Cyst | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | | __________________________________________________________________________| Thymus | + + + + + M M + + + M + + + M M + + + + + + + + M| Ectopic Parathyroid Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + M + + M + M + + + + M + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 2 1 2 4 2 2 2 3 2 2 2 2 1 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Fibrous Osteodystrophy | X X | Femur, Fibrous Osteodystrophy | X X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Mediastinum, Mineralization | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Chronic Active | 2 2 3 2 3 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + +| _____________________________________________________________________________________________________________________| Page 112 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 7| 5| 5| 7| 3| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 6| DAY ON TEST | 0| 3| 5| 5| 3| 7| 4| 0| 8| 3| 0| 7| 1| 4| 4| 1| 4| 4| 4| 9| 4| 7| 0| 0| 4| | 7| 8| 2| 2| 8| 1| 7| 9| 7| 8| 1| 8| 3| 1| 1| 5| 1| 2| 0| 3| 1| 8| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Hemorrhage | 2 | Inflammation, Chronic Active | 4| Lens, Cataract | 4 2 4 | Retina, Atrophy | 4 3 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 2 2 3 3 2 2 2 1 3 3 4 3 3 3 3 1 3 4 3 2 4 2 3 4 3| Renal Tubule, Epithelium, Hyperplasia| | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 113 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 5| 5| 7| 6| 7| 6| 6| 6| 7| 6| 6| 6| 4| 7| 7| 6| 6| 7| 6| | DAY ON TEST | 3| 4| 9| 0| 4| 6| 3| 9| 4| 7| 1| 5| 9| 4| 4| 4| 4| 8| 2| 4| 4| 9| 2| 4| 9| | | 6| 3| 9| 5| 3| 1| 8| 9| 4| 8| 3| 7| 2| 7| 4| 2| 3| 1| 9| 4| 5| 7| 6| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A A + + + + + + + + + + A + + + + A + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + M + + + + + + + + + + + A + + + + + + + + +| 45 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 5 | Clear Cell Focus | X | 1 | Degeneration, Cystic | 3 2 3 3 2 2 2 1 1 3| 21 2.3| Hyperplasia | 4 4 | 2 4.0| Inflammation, Chronic | | 1 2.0| Necrosis, Coagulative | 3 3 3 | 6 2.8| __________________________________________________________________________|____________| Mesentery | + + +| 3 | Inflammation, Chronic Active | 4| 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Inflammation, Chronic Active | | 1 2.0| Acinus, Atrophy | 1 1 2 2 1 2 2 2 2 | 18 1.8| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 3 2.7| Hyperkeratosis | 2 | 3 2.0| Hyperplasia, Squamous | | 1 3.0| Inflammation, Chronic Active | 3 | 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Mineralization | 2 | 3 2.0| Necrosis, Coagulative | | 1 3.0| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 114 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 5| 5| 7| 6| 7| 6| 6| 6| 7| 6| 6| 6| 4| 7| 7| 6| 6| 7| 6| | DAY ON TEST | 3| 4| 9| 0| 4| 6| 3| 9| 4| 7| 1| 5| 9| 4| 4| 4| 4| 8| 2| 4| 4| 9| 2| 4| 9| | | 6| 3| 9| 5| 3| 1| 8| 9| 4| 8| 3| 7| 2| 7| 4| 2| 3| 1| 9| 4| 5| 7| 6| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 47 2.3| Mineralization | 2 | 3 2.3| Atrium, Thrombosis | X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 | Degeneration, Fatty | 2 2 2 | 10 1.7| Hyperplasia | 2 1 2 2 1 1 1 | 16 1.8| Hypertrophy | | 5 2.2| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematocyst | X | 1 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | 21 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 3 4 | 5 3.8| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Pars Distalis, Cyst | X X X | 3 | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2| 12 1.9| Pars Intermedia, Cyst | X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 3 2 2 2 2 2 1 2 2 2 4 1 2 2| 27 2.0| Follicular Cell, Hyperplasia | 3 2 3 3 2 2 2 2 4 2 3 1 4 1 3 2 2 2 3 3 1 2 2 1| 47 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 3 | 2 3.5| Hypertrophy | 2 | 1 2.0| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 3 2 2 2 2| 47 2.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X| 1 | Inflammation, Chronic Active | 1 2 2 2 2 1 3 4 1 1 2| 25 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 115 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 5| 5| 7| 6| 7| 6| 6| 6| 7| 6| 6| 6| 4| 7| 7| 6| 6| 7| 6| | DAY ON TEST | 3| 4| 9| 0| 4| 6| 3| 9| 4| 7| 1| 5| 9| 4| 4| 4| 4| 8| 2| 4| 4| 9| 2| 4| 9| | | 6| 3| 9| 5| 3| 1| 8| 9| 4| 8| 3| 7| 2| 7| 4| 2| 3| 1| 9| 4| 5| 7| 6| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Epithelium, Hyperplasia | 3 | 2 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | 4 | 1 4.0| Interstitial Cell, Hyperplasia | 2 2 2 | 5 2.0| Seminiferous Tubule, Atrophy | 3 | 6 3.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + +| 26 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myeloid Cell, Atrophy | 4| 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Cyst | X | 2 | Mandibular, Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 10 | Cyst | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 4 2.3| Hematopoietic Cell Proliferation | 2 | 2 2.5| Necrosis, Coagulative | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | M M + + + + + + + + + M + + + + M M + M + + + + +| 38 | Ectopic Parathyroid Gland | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + + + + + + M + + M + + M + + + + + + + + +| 41 | Hyperplasia, Cystic | 2 1 2 2 1 2 3 2 2 2 1 3 3 1 1 2 1 1 1 2| 37 1.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Fibrous Osteodystrophy | X | 3 | Femur, Fibrous Osteodystrophy | X | 3 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 116 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 5| 5| 7| 6| 7| 6| 6| 6| 7| 6| 6| 6| 4| 7| 7| 6| 6| 7| 6| | DAY ON TEST | 3| 4| 9| 0| 4| 6| 3| 9| 4| 7| 1| 5| 9| 4| 4| 4| 4| 8| 2| 4| 4| 9| 2| 4| 9| | | 6| 3| 9| 5| 3| 1| 8| 9| 4| 8| 3| 7| 2| 7| 4| 2| 3| 1| 9| 4| 5| 7| 6| 5| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 1 | 3 2.3| Mediastinum, Mineralization | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X | 1 | Inflammation, Chronic Active | 4 3 3 2 2 2 2 | 13 2.5| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 4 2 2 | 5 2.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 5 | Hemorrhage | | 1 2.0| Inflammation, Chronic Active | | 1 4.0| Lens, Cataract | | 3 3.3| Retina, Atrophy | | 3 3.7| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy, Chronic | 2 2 3 3 2 2 3 3 4 3 4 3 4 3 3 2 3 4 2 3 3 2 2 3 2| 50 2.8| Renal Tubule, Epithelium, Hyperplasia| 4 4 4 | 3 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 117 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 6| 5| 3| 7| 7| 5| 5| 4| 7| 5| 6| 6| 7| 6| 5| 5| 6| 7| 7| 7| DAY ON TEST | 2| 3| 4| 5| 3| 8| 8| 9| 3| 3| 7| 2| 6| 4| 2| 9| 5| 4| 6| 8| 9| 1| 1| 1| 4| | 8| 2| 0| 0| 1| 7| 0| 1| 8| 8| 9| 9| 1| 1| 3| 7| 7| 1| 4| 0| 7| 1| 2| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + A + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | X X X X X X X X X| Degeneration, Cystic | 3 2 4 3 2 1 3 1 2 4 3 2 1 4 | Inflammation, Chronic | 2 2 | Necrosis, Coagulative | 3 2 2 1 3 2 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic Active | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 4 | Acinus, Atrophy | 3 1 2 2 2 2 3 2 4 3| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 3 2 2 2 2 2 3 2 3 2 2 3 2 2 2 3 3 2 3 3 3| Mineralization | 2 | Atrium, Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2 2 2 2 2 1 2 2 2 | Hyperplasia | 2 2 2 2 2 3 | Vacuolization Cytoplasmic | 2| _____________________________________________________________________________________________________________________| Page 118 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 6| 5| 3| 7| 7| 5| 5| 4| 7| 5| 6| 6| 7| 6| 5| 5| 6| 7| 7| 7| DAY ON TEST | 2| 3| 4| 5| 3| 8| 8| 9| 3| 3| 7| 2| 6| 4| 2| 9| 5| 4| 6| 8| 9| 1| 1| 1| 4| | 8| 2| 0| 0| 1| 7| 0| 1| 8| 8| 9| 9| 1| 1| 3| 7| 7| 1| 4| 0| 7| 1| 2| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 2 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 4 | __________________________________________________________________________| Parathyroid Gland | + + + + M M M + M + + + + + + + + + + + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Atypia Cellular | X | Pars Distalis, Hyperplasia | 2 2 2 2 | Pars Distalis, Vacuolization | | Cytoplasmic | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2| Follicular Cell, Hyperplasia | 4 4 3 4 4 4 4 4 4 4 3 4 4 4 4 4 4 3 4 4 4 4 4 4| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 4 | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 1 2 1 2 2 2 1 2 1 1 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 2 2 1 4 3 1 2 2 1 1 2 2| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 1 2 2 1 1 | Seminiferous Tubule, Atrophy | 3 4 2 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + | Cyst | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 3 3 | Hematopoietic Cell Proliferation | 3 | Necrosis, Coagulative | 4 3 | __________________________________________________________________________| Thymus | + + M M M + + + + + + + + + + + + + + M + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 119 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 6| 5| 3| 7| 7| 5| 5| 4| 7| 5| 6| 6| 7| 6| 5| 5| 6| 7| 7| 7| DAY ON TEST | 2| 3| 4| 5| 3| 8| 8| 9| 3| 3| 7| 2| 6| 4| 2| 9| 5| 4| 6| 8| 9| 1| 1| 1| 4| | 8| 2| 0| 0| 1| 7| 0| 1| 8| 8| 9| 9| 1| 1| 3| 7| 7| 1| 4| 0| 7| 1| 2| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 3 2 2 2 3 2 2 2 1 2 2 2 2 2 3 2| __________________________________________________________________________| Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Fibrous Osteodystrophy | X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Hydrocephalus | | __________________________________________________________________________| Peripheral Nerve | + + | Sciatic, Degeneration | 2 2 | __________________________________________________________________________| Spinal Cord | + + | White Matter, Degeneration | 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 1 | Thrombosis | X | Vein, Mediastinum, Thrombosis | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Hemorrhage | 2 2 2 | Inflammation, Chronic Active | 2 2 3 2 2 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 3 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + | Lens, Cataract | 4 4 4 4 | Retina, Atrophy | 4 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 2 | _____________________________________________________________________________________________________________________| Page 120 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 6| 6| 5| 3| 7| 7| 5| 5| 4| 7| 5| 6| 6| 7| 6| 5| 5| 6| 7| 7| 7| DAY ON TEST | 2| 3| 4| 5| 3| 8| 8| 9| 3| 3| 7| 2| 6| 4| 2| 9| 5| 4| 6| 8| 9| 1| 1| 1| 4| | 8| 2| 0| 0| 1| 7| 0| 1| 8| 8| 9| 9| 1| 1| 3| 7| 7| 1| 4| 0| 7| 1| 2| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Nephropathy, Chronic | 4 2 3 2 4 3 3 4 4 3 2 2 2 4 2 3 3 4 2 2 3 2 3 3 3| Renal Tubule, Epithelium, Hyperplasia| 4 4 4 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 121 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 0| 0| 0| 0| 0| 7| 6| 6| 4| 7| | DAY ON TEST | 4| 8| 4| 4| 2| 2| 7| 7| 4| 4| 4| 9| 4| 9| 3| 3| 3| 3| 3| 3| 4| 5| 0| 7| 4| | | 2| 9| 2| 3| 2| 4| 7| 7| 3| 4| 4| 5| 4| 6| 9| 0| 0| 0| 0| 0| 5| 0| 3| 8| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + A + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + A + + A + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + A + + + + + + + + + +| 47 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + A M M M M M + + + + +| 43 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + A + + A + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + M + + + + + + A M M M M M + + + + +| 42 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 3.0| Basophilic Focus | X X X X X X | 15 | Degeneration, Cystic | 4 2 2 1 2 2 2 1 2 4 2 | 25 2.4| Inflammation, Chronic | 2 2 2 1 1 2 2 3| 10 1.9| Necrosis, Coagulative | | 6 2.2| Vacuolization Cytoplasmic | 2 | 2 2.0| __________________________________________________________________________|____________| Mesentery | | 2 | Inflammation, Chronic Active | | 2 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis, Coagulative | | 1 4.0| Acinus, Atrophy | 2 1 2 2 2 3 2 | 17 2.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 2 3 3 2 3 3 2 3 2 3 3 3 2 2 2 3| 39 2.4| Mineralization | | 1 2.0| Atrium, Thrombosis | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 122 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 0| 0| 0| 0| 0| 7| 6| 6| 4| 7| | DAY ON TEST | 4| 8| 4| 4| 2| 2| 7| 7| 4| 4| 4| 9| 4| 9| 3| 3| 3| 3| 3| 3| 4| 5| 0| 7| 4| | | 2| 9| 2| 3| 2| 4| 7| 7| 3| 4| 4| 5| 4| 6| 9| 0| 0| 0| 0| 0| 5| 0| 3| 8| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 1 2 1 2 | 14 1.8| Hyperplasia | 2 3 2 | 9 2.2| Vacuolization Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 3 2 2 2| 14 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + + M + M + M + + M M M + + + + + M M + + M +| 33 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Atypia Cellular | | 1 | Pars Distalis, Hyperplasia | 3 2 | 6 2.2| Pars Distalis, Vacuolization | | | Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 2 1 2 1 2 2 | 12 1.8| Follicular Cell, Hyperplasia | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 41 3.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | | 1 4.0| __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 41 1.9| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X X | 2 | Inflammation, Chronic Active | 2 1 2 1 2 2 2 2 2 2 2 3 3 1 | 27 1.9| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | | 6 1.3| Seminiferous Tubule, Atrophy | 4 4 4 2 | 8 3.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + | 14 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 123 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 0| 0| 0| 0| 0| 7| 6| 6| 4| 7| | DAY ON TEST | 4| 8| 4| 4| 2| 2| 7| 7| 4| 4| 4| 9| 4| 9| 3| 3| 3| 3| 3| 3| 4| 5| 0| 7| 4| | | 2| 9| 2| 3| 2| 4| 7| 7| 3| 4| 4| 5| 4| 6| 9| 0| 0| 0| 0| 0| 5| 0| 3| 8| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Hyperplasia, Plasma Cell | 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 14 | Cyst | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 3 3 | 8 2.5| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis, Coagulative | | 2 3.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + + + M + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + +| 36 | Hyperplasia, Cystic | 3 4 2 2 3 2 3 1 2 2 1 2 3 | 31 2.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Femur, Fibrous Osteodystrophy | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X | 1 | Hydrocephalus | 2 | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | + + + + | 6 | Sciatic, Degeneration | | 2 2.0| __________________________________________________________________________|____________| Spinal Cord | + + + + + | 7 | White Matter, Degeneration | | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 1 2 | 6 1.8| Thrombosis | | 1 | Vein, Mediastinum, Thrombosis | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | X | 1 | Hemorrhage | | 3 2.0| Inflammation, Chronic Active | 3 2 3 | 9 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 124 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 0| 0| 0| 0| 0| 7| 6| 6| 4| 7| | DAY ON TEST | 4| 8| 4| 4| 2| 2| 7| 7| 4| 4| 4| 9| 4| 9| 3| 3| 3| 3| 3| 3| 4| 5| 0| 7| 4| | | 2| 9| 2| 3| 2| 4| 7| 7| 3| 4| 4| 5| 4| 6| 9| 0| 0| 0| 0| 0| 5| 0| 3| 8| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Nasolacrimal Duct, Inflammation, | | | Suppurative | 1 1 4 1 | 7 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + + + + + | 6 | __________________________________________________________________________|____________| Eye | + + + + + + | 11 | Lens, Cataract | 3 | 5 3.8| Retina, Atrophy | 4 | 5 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Zymbal's Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | | 1 2.0| Nephropathy, Chronic | 3 2 3 3 4 3 3 3 3 3 3 3 3 3 4 2 4 2 4 3| 45 3.0| Renal Tubule, Epithelium, Hyperplasia| 4 4 4 | 7 3.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 125 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 4| 5| 5| 6| 6| 5| 6| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 1| 1| 3| 2| 9| 5| 2| 5| 4| 2| 8| 9| 9| 1| 5| 7| 4| 0| 4| 3| 3| 3| 4| | 7| 5| 3| 3| 8| 3| 7| 4| 8| 4| 0| 3| 6| 8| 8| 8| 8| 6| 2| 6| 1| 2| 4| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + A +| Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M A + A +| Parasite Metazoan | X | Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis, Coagulative | 4 | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + A + M + + + A + M +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | X| Clear Cell Focus | X X X X | Degeneration, Cystic | 1 2 2 1 1 2 3 1 2 1 3 | Inflammation, Chronic | 1 | Leukocytosis | X| Necrosis, Coagulative | 3 2| Thrombosis | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + | Artery, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 2 1 1 1 1 2 | Artery, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis | 3 | Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | 4 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 3 2 | Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 126 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 4| 5| 5| 6| 6| 5| 6| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 1| 1| 3| 2| 9| 5| 2| 5| 4| 2| 8| 9| 9| 1| 5| 7| 4| 0| 4| 3| 3| 3| 4| | 7| 5| 3| 3| 8| 3| 7| 4| 8| 4| 0| 3| 6| 8| 8| 8| 8| 6| 2| 6| 1| 2| 4| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 3 3 2 2 2 2 3 2 3 3 2 2 2 2 3 2 3 2 2 2| Artery, Inflammation, Chronic Active | 3 | Atrium, Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 3 2 2 3 2 2 1 | Hyperplasia | 1 2 | Hypertrophy, Focal | | Necrosis, Coagulative | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 | Necrosis, Coagulative | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M + M + + M M M M + M M M M M M M M M M M M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + + + + +| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | 4 | C-Cell, Hyperplasia | 2 2 1 2 2 2 2 | Follicular Cell, Hyperplasia | 2 3 2 3 3 2 2 2 3 4 4 4 4 4 4 4 4 3 4| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 3 1 3 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Inflammation, Chronic Active | 1 1 1 2 2 2 4 1 2 3 2 3 2 2 1| __________________________________________________________________________| Seminal Vesicle | + | Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 4 | Interstitial Cell, Hyperplasia | 2 2 1 1 | Seminiferous Tubule, Atrophy | 3 4 | _____________________________________________________________________________________________________________________| Page 127 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 4| 5| 5| 6| 6| 5| 6| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 1| 1| 3| 2| 9| 5| 2| 5| 4| 2| 8| 9| 9| 1| 5| 7| 4| 0| 4| 3| 3| 3| 4| | 7| 5| 3| 3| 8| 3| 7| 4| 8| 4| 0| 3| 6| 8| 8| 8| 8| 6| 2| 6| 1| 2| 4| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Plasma Cell | 3 2 3| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Artery, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Thymus | + + M M + + + + + + + + + + + M + + + + + + + + +| Ectopic Parathyroid Gland | | Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 1 1 1 1 1 1 4 3 1 2 1 2 1 1 1| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Artery, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Artery, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 3 | Inflammation, Chronic Active | 2 3 3 3 3 | Thrombosis | | Artery, Mediastinum, Inflammation, | | Chronic Active | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 3 | Fungus | X X | Inflammation, Chronic Active | 3 3 2 1 2 1 3 4 2 1| _____________________________________________________________________________________________________________________| Page 128 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 4| 5| 5| 6| 6| 5| 6| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 1| 1| 3| 2| 9| 5| 2| 5| 4| 2| 8| 9| 9| 1| 5| 7| 4| 0| 4| 3| 3| 3| 4| | 7| 5| 3| 3| 8| 3| 7| 4| 8| 4| 0| 3| 6| 8| 8| 8| 8| 6| 2| 6| 1| 2| 4| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nasolacrimal Duct, Foreign Body | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + | Lens, Cataract | 4 3 4 3 4 3 | Retina, Atrophy | 4 4 4 4 4 | __________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Zymbal's Gland | + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Coagulative | | Nephropathy, Chronic | 1 2 4 3 4 3 3 2 2 3 3 3 2 3 3 2 4 3 4 3 3 4 3 2 2| Artery, Inflammation, Chronic Active | 4 | Renal Tubule, Epithelium, Hyperplasia| 3 4 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 129 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 4| 7| 6| 7| 5| 6| 6| 6| 6| 7| 5| 5| 5| 4| 5| 6| 7| | DAY ON TEST | 9| 1| 1| 3| 0| 8| 5| 7| 3| 2| 3| 4| 8| 2| 1| 4| 5| 1| 2| 3| 8| 1| 4| 3| 4| | | 8| 8| 8| 4| 4| 2| 4| 1| 8| 4| 4| 3| 3| 0| 9| 6| 7| 2| 1| 8| 5| 8| 4| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + A + A + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + A + A + A + A + + A + + M + + + A A +| 39 | Artery, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + A + + + + + + + + + + + +| 47 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + A + + + + + + + + + + + +| 45 | Parasite Metazoan | X X | 3 | Artery, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 4 | 1 4.0| Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + A M + + A + A + + + + + + + + + + A +| 39 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + A + A + + + + + + + + + + A +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 2 3.5| Basophilic Focus | X X | 3 | Clear Cell Focus | | 4 | Degeneration, Cystic | 1 2 3 3 3 4| 17 2.1| Inflammation, Chronic | 2 2 | 3 1.7| Leukocytosis | | 1 | Necrosis, Coagulative | 1 3 | 4 2.3| Thrombosis | X | 1 | Vacuolization Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + | 3 | Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 2 2 2 4 2 2 1 1 2 | 19 1.6| Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 2 | 2 2.0| Necrosis | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | | 3 3.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 130 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 4| 7| 6| 7| 5| 6| 6| 6| 6| 7| 5| 5| 5| 4| 5| 6| 7| | DAY ON TEST | 9| 1| 1| 3| 0| 8| 5| 7| 3| 2| 3| 4| 8| 2| 1| 4| 5| 1| 2| 3| 8| 1| 4| 3| 4| | | 8| 8| 8| 4| 4| 2| 4| 1| 8| 4| 4| 3| 3| 0| 9| 6| 7| 2| 1| 8| 5| 8| 4| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 3 2 | 2 2.5| Mineralization | | 2 2.5| Artery, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 3 2 3 3 2 3 2 2 2 2 2 | 43 2.3| Artery, Inflammation, Chronic Active | | 1 3.0| Atrium, Thrombosis | X X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 3 2 2 2 2 2| 13 2.2| Hyperplasia | 2 2 2 2 | 6 1.8| Hypertrophy, Focal | 3 | 1 3.0| Necrosis, Coagulative | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 | 17 2.0| Necrosis, Coagulative | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + M M + M + M M M + + + + + M + + + M + + M +| 21 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | X X X X X X| 8 | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 16 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 1 4.0| Artery, Inflammation, Chronic Active | | 1 4.0| C-Cell, Hyperplasia | 2 2| 9 1.9| Follicular Cell, Hyperplasia | 4 4 4 4 4 4 2 4 4 4 4 4 2 2 4 4 4 4 4 4| 39 3.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 131 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 4| 7| 6| 7| 5| 6| 6| 6| 6| 7| 5| 5| 5| 4| 5| 6| 7| | DAY ON TEST | 9| 1| 1| 3| 0| 8| 5| 7| 3| 2| 3| 4| 8| 2| 1| 4| 5| 1| 2| 3| 8| 1| 4| 3| 4| | | 8| 8| 8| 4| 4| 2| 4| 1| 8| 4| 4| 3| 3| 0| 9| 6| 7| 2| 1| 8| 5| 8| 4| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 1 1 1 2 1 2| 42 1.9| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Inflammation, Chronic Active | 1 1 2 2 1 1 3 2 2 3 1 2 | 27 1.9| __________________________________________________________________________|____________| Seminal Vesicle | + | 2 | Artery, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Artery, Inflammation, Chronic Active | | 1 4.0| Interstitial Cell, Hyperplasia | 1 2 2 1 | 8 1.5| Seminiferous Tubule, Atrophy | 4 2 4 2 4| 7 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + +| 22 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Mandibular, Hyperplasia, Plasma Cell | | 3 2.7| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + +| 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 3 4 2 | 6 2.5| Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + M M +| 44 | Ectopic Parathyroid Gland | X | 1 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + | 37 | Hyperplasia, Cystic | 2 1 2 4 1 4 3 2 1 1 2 1 2 4 2 2 1 2 1 | 37 1.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperkeratosis | | 1 3.0| Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Artery, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 132 NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97 Route: DOSED FEED Time: 17:58:07 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 4| 7| 6| 7| 5| 6| 6| 6| 6| 7| 5| 5| 5| 4| 5| 6| 7| | DAY ON TEST | 9| 1| 1| 3| 0| 8| 5| 7| 3| 2| 3| 4| 8| 2| 1| 4| 5| 1| 2| 3| 8| 1| 4| 3| 4| | | 8| 8| 8| 4| 4| 2| 4| 1| 8| 4| 4| 3| 3| 0| 9| 6| 7| 2| 1| 8| 5| 8| 4| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | | 1 4.0| Artery, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 3 3 2 4 3 | 10 2.9| Thrombosis | X | 1 | Artery, Mediastinum, Inflammation, | | | Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 3.0| Fungus | X X X| 5 | Inflammation, Chronic Active | 3 4 3 3 2 3| 16 2.5| Nasolacrimal Duct, Foreign Body | | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 1 3 1 2 | 6 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + | 10 | Lens, Cataract | 3 4 4 | 9 3.6| Retina, Atrophy | 4 4 4 | 8 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Zymbal's Gland | + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Coagulative | 2| 1 2.0| Nephropathy, Chronic | 3 3 4 2 2 3 3 3 2 3 4 3 2 3 2 2 3 4 3 2 3 2 3 2 2| 50 2.8| Artery, Inflammation, Chronic Active | | 1 4.0| Renal Tubule, Epithelium, Hyperplasia| | 2 3.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 133 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 1259462-1259462/1259462 --multipart-boundary--