TR 388 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05076 ETHYLENETHIOUREA TIME: 21:06:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 03372
CONT: N01ES82151 CAS: 96-45-7
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/09/94
EXP: 05076 ETHYLENETHIOUREA TIME: 21:06:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 03372
CONT: N01ES82151 CAS: 96-45-7
PATHOLOGIST: J. TOFT S. EUSTIS
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 155 307 372 472 472 507 512 517 520 586 |
| 592 597 615 619 628 628 633 633 643 647 |
| 674 676 692 696 698 701 702 709 712 719 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 416 435 501 507 538 552 552 571 577 587 |
| 603 605 622 633 636 640 650 650 671 677 |
| 678 689 692 698 707 710 711 712 712 718 |
| 720 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM 1-1 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 230 368 382 395 444 497 536 565 580 611 |
| 626 642 642 646 657 660 671 674 691 692 |
| 696 697 703 705 705 710 720 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 83 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 183 276 381 395 453 479 486 503 503 522 |
| 565 585 590 592 603 605 612 622 628 632 |
| 653 657 661 664 678 678 695 710 713 713 |
| 726 732 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 83 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 42 447 453 466 541 594 596 597 603 615 |
| 617 618 619 632 634 640 643 647 650 653 |
| 670 671 678 678 696 696 698 708 710 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 83 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 371 429 493 507 536 538 552 552 599 599 |
| 601 615 626 640 640 642 643 647 647 657 |
| 661 678 678 678 681 687 692 692 697 701 |
| 705 708 709 713 713 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 5 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 391 461 478 523 529 579 580 580 596 597 |
| 603 611 631 632 639 640 650 650 657 664 |
| 677 677 687 689 695 697 712 719 722 724 |
| 728 |
| CENSORED DEATHS |
| 30 30 30 30 30 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 44 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 418 438 486 506 521 527 528 538 544 555 |
| 576 583 585 597 598 598 604 618 618 618 |
| 619 620 634 634 636 640 640 642 646 654 |
| 654 654 657 658 671 682 698 712 713 713 |
| 723 723 724 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 98.0 98.0 96.0 94.0 90.0 82.0 76.0 60.0 38.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 98.0 96.0 90.0 76.0 64.0 36.0 |
|PPM 10-0 | |
| | |
|25 | 100.0 100.0 98.0 98.0 92.0 90.0 86.0 82.0 68.0 44.0 |
|PPM 1-1 | |
| | |
|83 | 100.0 100.0 98.0 96.0 92.0 88.0 80.0 68.0 52.0 34.0 |
|PPM 0-3 | |
| | |
|83 | 98.0 98.0 98.0 98.0 98.0 92.0 90.0 82.0 60.0 40.0 |
|PPM 3-3 | |
| | |
|83 | 100.0 100.0 100.0 100.0 98.0 96.0 88.0 78.0 58.0 30.0 |
|PPM 10-3 | |
| | |
|250 | 100.0 100.0 100.0 100.0 97.8 93.3 88.9 75.6 55.6 31.1 |
|PPM 0-10 | |
| | |
|250 | 100.0 100.0 100.0 100.0 98.0 96.0 82.0 66.0 32.0 12.0 |
|PPM 10-10 | |
| | |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 25 83 83 83 250 250 |
| PPM 10-0 PPM 1-1 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-1|
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.0% 36.0% 44.0% 34.0% 40.0% 30.0% 31.1% 12.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.004 ----- P=0.555N P=0.732 P=0.917N P=0.644 P=0.735 P=0.009 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 592.3 627.8 602.6 582.6 607.9 626.5 626.4 616.7 |
|NATURAL DEATHS (C) | (23.6) (14.9) (24.5) (23.0) (23.5) (14.1) (14.9) (11.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.7 665.7 660.0 633.8 657.9 658.4 596.6 630.7 |
|(STANDARD ERROR) | (17.5) (11.9) (16.5) (18.2) (16.5) (12.1) (29.3) (11.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 424 466 494 508 523 526 538 544 547 559 |
| 561 561 594 624 642 654 657 658 667 694 |
| 707 718 718 721 721 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 236 431 480 488 494 528 592 592 609 658 |
| 668 674 683 690 694 704 706 712 713 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM 1-1 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 447 511 523 557 581 606 610 636 652 679 |
| 696 699 700 705 721 735 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 83 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 372 461 497 587 603 604 637 638 638 654 |
| 665 669 671 711 718 726 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 83 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 312 431 494 501 574 585 587 597 605 622 |
| 637 638 651 659 665 677 683 685 694 698 |
| 712 713 738 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 83 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 437 494 550 558 564 590 642 657 687 694 |
| 704 706 712 720 721 725 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 740 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 250 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 487 547 570 573 588 592 601 605 613 621 |
| 628 638 657 660 666 676 677 679 684 690 |
| 694 694 698 707 717 726 726 726 726 734 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 462 469 538 544 548 564 565 565 573 576 |
| 592 592 598 600 606 607 614 614 620 620 |
| 624 637 638 642 642 676 679 679 684 689 |
| 694 707 707 713 713 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 740 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 740 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 100.0 100.0 98.0 96.0 84.0 74.0 64.0 48.0 |
| | |
| | |
|0 | 100.0 100.0 98.0 98.0 98.0 94.0 88.0 84.0 80.0 60.0 |
|PPM 10-0 | |
| | |
|25 PPM 1-1| 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 82.0 68.0 |
| | |
| | |
|83 | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 88.0 78.0 66.0 |
|PPM 0-3 | |
| | |
|83 | 100.0 100.0 100.0 98.0 98.0 96.0 92.0 82.0 70.0 54.0 |
|PPM 3-3 | |
| | |
|83 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 88.0 84.0 66.0 |
|PPM 10-3 | |
| | |
|250 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 84.0 72.0 40.0 |
|PPM 0-10 | |
| | |
|250 | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 72.0 50.0 28.0 |
|PPM 10-10| |
| | |
==================================================================================
ETHYLENETHIOUREA
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 740 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 25 PPM 1-1 83 83 83 250 250 |
| PPM 10-0 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 60.0% 68.0% 66.0% 54.0% 66.0% 40.0% 28.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 ----- P=0.052N P=0.080N P=0.604N P=0.065N P=0.849 P=0.069 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.8 603.7 628.6 622.5 615.6 640.4 653.3 619.6 |
|NATURAL DEATHS (C) | (17.7) (28.3) (21.4) (23.8) (21.1) (22.0) (11.4) (10.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.2 685.5 704.4 700.1 682.8 706.1 688.0 653.3 |
|(STANDARD ERROR) | (13.2) (14.7) (10.0) (11.2) (13.0) (10.0) ( 9.1) (11.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLENETHIOUREA
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
25 PPM 1-1 = 3
83 PPM 0-3 = 4
83 PPM 3-3 = 5
83 PPM 10-3 = 6
250 PPM 0-10 = 7
250 PPM 10-10 = 8
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 5 1 4 3 6 7 2
| 5 1 4 3 4 1 3 7 2 625 7
| 4 1 31 3 3 625 575178622
| 3 3 4 5 7 2 7 25
90 + 3 4 14 3 1 77252 7 5
| 443 11 3 6 55
| 4 4 1 18382 322 55
| 4 1 8 8 21 753
80 + 4 84 81 1 2353
| 4 84 1176 3 3
P | 4 412116233
E | 4 47117 33
R 70 + 22 3 3
C | 844 1122 33
E | 8444112 23 3
N | 44115 22
T 60 + 4 14 651 33
| 7 6 2 2
S | 8 8 4 451 113
U | 4 46 22
R 50 + 88 766112
V | 4 74 33
I | 88 641133 3
V | 88 66115
A 40 + 411 5
L | 6671 1
| 2 2
| 8 8
30 + 8 8 6 7 6
| 8 8
| 8 8
|
20 + 8 8
|
| 8 8
| 8
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 119 obs hidden.
ETHYLENETHIOUREA
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
25 PPM 1-1 = 3
83 PPM 0-3 = 4
83 PPM 3-3 = 5
83 PPM 10-3 = 6
250 PPM 0-10 = 7
250 PPM 10-10 = 8
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 5 4 1 63 8 7
| 2 5 4 1263 41 76 3 7
| 2 41 22151 3 8863 7 4
| 2251 1 8836534 4
90 + 2 11 8 6535 6 3
| 11 2733 46
| 111 88 5 2523 34 3 6
| 11 88 275 4 2 3 66
P 80 + 11 8 8 575 2 423 36
E | 755 422
R | 1 18 1 557 542223346
C | 88 1 1 77 22343
E 70 + 1 1 575 22 34 3
N | 88 55 4 33
T | 88 1 175 522 6 44
| 1 771 22
S 60 + 88 71152 2
U | 88 1 1
R | 88 775 5
V | 7 7
I 50 + 8 8 11
V | 1 1
A | 88
L | 88 7 7
40 + 88 77
| 88
| 88
|
30 + 88
| 8 8
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 80 obs hidden.
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