TR 389 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. SODIUM AZIDE DATE: 09/04/94
EXPERIMENT: 05026 TEST: 01 TIME: 07:56:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01C09565001 ROUTE: GAVAGE NTP C#: 06462
PATHOLOGIST: G. PARKER CAS: 26628228
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. SODIUM AZIDE DATE: 09/04/94
EXPERIMENT: 05026 TEST: 01 TIME: 07:56:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01C09565001 ROUTE: GAVAGE NTP C#: 06462
PATHOLOGIST: G. PARKER CAS: 26628228
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. SODIUM AZIDE DATE: 09/04/94
EXPERIMENT: 05026 TEST: 01 TIME: 07:56:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01C09565001 ROUTE: GAVAGE NTP C#: 06462
PATHOLOGIST: G. PARKER CAS: 26628228
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF SODIUM AZIDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Mammary Gland Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Testes Adenoma
Zymbal's Gland Carcinoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Osteosarcoma
Osteosarcoma or Osteoma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) | 1/60 (2%) 2/60 (3%) 0/58 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.3% 4.7% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 2/43 (5%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 684 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.500N P=0.554 P=0.616N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.400N P=0.547 P=0.398N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.456N P=0.540 P=0.556N |
|COCHRAN-ARMITAGE | (e) | P=0.369N |
|FISHER EXACT | (e) (e) | P=0.500 P=0.508N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/55 (45%) 15/56 (27%) 4/54 (7%) | 1/58 (2%) 4/54 (7%) 1/56 (2%) |
|ADJUSTED (b) | 70.5% 50.0% 35.6% | 2.3% 9.5% 4.8% |
|TERMINAL (d) | 14/24 (58%) 11/25 (44%) 2/8 (25%) | 0/36 (0%) 4/42 (10%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 555 579 662 | 684 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011N* P=0.027N* P=0.056N | P=0.407 P=0.231 P=0.631 |
|INCIDENTAL TUMOR | P<0.001N** P=0.016N* P<0.001N** | P=0.489 P=0.182 P=0.765 |
|LOGISTIC REGRESSION | P<0.001N** P=0.015N* P=0.002N** | P=0.441 P=0.199 P=0.690 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.586 |
|FISHER EXACT | P=0.032N* P<0.001N** | P=0.160 P=0.743 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 1/56 (2%) 2/54 (4%) | 0/58 (0%) 1/54 (2%) 0/56 (0%) |
|ADJUSTED (b) | 4.2% 4.0% 19.8% | 0.0% 2.4% 0.0% |
|TERMINAL (d) | 1/24 (4%) 1/25 (4%) 1/8 (13%) | 0/36 (0%) 1/42 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 681 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.118 P=0.754N P=0.154 | P=0.680 P=0.531 (e) |
|INCIDENTAL TUMOR | P=0.194 P=0.754N P=0.293 | P=0.680 P=0.531 (e) |
|LOGISTIC REGRESSION | P=0.159 P=0.754N P=0.229 | P=0.680 P=0.531 (e) |
|COCHRAN-ARMITAGE | P=0.372 | P=0.724 |
|FISHER EXACT | P=0.748N P=0.493 | P=0.482 (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/55 (47%) 16/56 (29%) 6/54 (11%) | 1/58 (2%) 5/54 (9%) 1/56 (2%) |
|ADJUSTED (b) | 73.4% 53.6% 50.8% | 2.3% 11.9% 4.8% |
|TERMINAL (d) | 15/24 (63%) 12/25 (48%) 3/8 (38%) | 0/36 (0%) 5/42 (12%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 555 579 662 | 684 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041N* P=0.026N* P=0.169N | P=0.383 P=0.144 P=0.631 |
|INCIDENTAL TUMOR | P<0.001N** P=0.015N* P=0.001N** | P=0.459 P=0.111 P=0.765 |
|LOGISTIC REGRESSION | P=0.003N** P=0.014N* P=0.010N* | P=0.413 P=0.120 P=0.690 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.577 |
|FISHER EXACT | P=0.033N* P<0.001N** | P=0.087 P=0.743 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/59 (12%) 9/59 (15%) 3/55 (5%) | 4/55 (7%) 2/57 (4%) 5/49 (10%) |
|ADJUSTED (b) | 21.3% 26.7% 18.4% | 10.4% 4.0% 21.7% |
|TERMINAL (d) | 3/24 (13%) 6/27 (22%) 1/9 (11%) | 2/34 (6%) 1/42 (2%) 4/20 (20%) |
|FIRST INCIDENCE (DAYS) | 495 502 649 | 684 502 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.543N P=0.461 P=0.582N | P=0.210 P=0.260N P=0.215 |
|INCIDENTAL TUMOR | P=0.235N P=0.501 P=0.267N | P=0.415 P=0.312N P=0.412 |
|LOGISTIC REGRESSION | P=0.276N P=0.394 P=0.321N | P=0.353 P=0.325N P=0.366 |
|COCHRAN-ARMITAGE | P=0.180N | P=0.362 |
|FISHER EXACT | P=0.394 P=0.191N | P=0.323N P=0.426 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/59 (2%) 0/55 (0%) | 1/55 (2%) 2/57 (4%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% | 2.0% 4.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/34 (0%) 1/42 (2%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | --- 723 --- | 594 453 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.636 P=0.523 (e) | P=0.434N P=0.545 P=0.550N |
|INCIDENTAL TUMOR | P=0.720N P=0.489 (e) | P=0.348N P=0.445 P=0.536N |
|LOGISTIC REGRESSION | P=0.645 P=0.520 (e) | P=0.355N P=0.348 P=0.504N |
|COCHRAN-ARMITAGE | P=0.722 | P=0.389N |
|FISHER EXACT | P=0.500 (e) | P=0.514 P=0.529N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/59 (12%) 10/59 (17%) 3/55 (5%) | 5/55 (9%) 4/57 (7%) 5/49 (10%) |
|ADJUSTED (b) | 21.3% 29.3% 18.4% | 12.2% 7.9% 21.7% |
|TERMINAL (d) | 3/24 (13%) 6/27 (22%) 1/9 (11%) | 2/34 (6%) 2/42 (5%) 4/20 (20%) |
|FIRST INCIDENCE (DAYS) | 495 502 649 | 594 453 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.552 P=0.369 P=0.582N | P=0.327 P=0.399N P=0.326 |
|INCIDENTAL TUMOR | P=0.240N P=0.393 P=0.267N | P=0.568N P=0.509N P=0.540 |
|LOGISTIC REGRESSION | P=0.301N P=0.301 P=0.321N | P=0.513 P=0.575N P=0.514 |
|COCHRAN-ARMITAGE | P=0.187N | P=0.497 |
|FISHER EXACT | P=0.301 P=0.191N | P=0.477N P=0.554 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/59 (5%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 0/58 (0%) |
|ADJUSTED (b) | 10.6% 5.8% 2.2% | 2.7% 2.3% 0.0% |
|TERMINAL (d) | 2/24 (8%) 1/27 (4%) 0/9 (0%) | 1/37 (3%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 658 641 466 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411N P=0.455N P=0.563N | P=0.430N P=0.728N P=0.613N |
|INCIDENTAL TUMOR | P=0.262N P=0.499N P=0.352N | P=0.430N P=0.728N P=0.613N |
|LOGISTIC REGRESSION | P=0.256N P=0.484N P=0.349N | P=0.430N P=0.728N P=0.613N |
|COCHRAN-ARMITAGE | P=0.217N | P=0.338N |
|FISHER EXACT | P=0.492N P=0.303N | P=0.752N P=0.508N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/58 (0%) |
|ADJUSTED (b) | 7.0% 6.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 703 693 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372N P=0.652N P=0.483N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.194N P=0.691 P=0.214N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.294N P=0.675N P=0.389N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.173N | (e) |
|FISHER EXACT | P=0.684N P=0.244N | (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/59 (8%) 4/60 (7%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 0/58 (0%) |
|ADJUSTED (b) | 16.9% 12.0% 2.2% | 2.7% 2.3% 0.0% |
|TERMINAL (d) | 2/24 (8%) 2/27 (7%) 0/9 (0%) | 1/37 (3%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 658 641 466 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.274N P=0.437N P=0.367N | P=0.430N P=0.728N P=0.613N |
|INCIDENTAL TUMOR | P=0.103N P=0.503N P=0.108N | P=0.430N P=0.728N P=0.613N |
|LOGISTIC REGRESSION | P=0.134N P=0.473N P=0.164N | P=0.430N P=0.728N P=0.613N |
|COCHRAN-ARMITAGE | P=0.078N | P=0.338N |
|FISHER EXACT | P=0.489N P=0.100N | P=0.752N P=0.508N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 8.3% 3.7% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/24 (8%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 645 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.601N P=0.459N P=0.717 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.559N P=0.459N P=0.705N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.558N P=0.459N P=0.709N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.378N | (e) |
|FISHER EXACT | P=0.500N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) |
|ADJUSTED (b) | 8.3% 3.7% 3.4% | 0.0% 0.0% 2.7% |
|TERMINAL (d) | 2/24 (8%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 645 | --- --- 642 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.601N P=0.459N P=0.717 | P=0.231 (e) P=0.452 |
|INCIDENTAL TUMOR | P=0.559N P=0.459N P=0.705N | P=0.233 (e) P=0.433 |
|LOGISTIC REGRESSION | P=0.558N P=0.459N P=0.709N | P=0.262 (e) P=0.480 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.267 |
|FISHER EXACT | P=0.500N P=0.500N | (e) P=0.496 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 11.5% 8.8% 0.0% | 2.7% 0.0% 0.0% |
|TERMINAL (d) | 2/24 (8%) 1/27 (4%) 0/9 (0%) | 1/37 (3%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 703 632 --- | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.254N P=0.602N P=0.345N | P=0.322N P=0.470N P=0.613N |
|INCIDENTAL TUMOR | P=0.169N P=0.652 P=0.236N | P=0.322N P=0.470N P=0.613N |
|LOGISTIC REGRESSION | P=0.201N P=0.644N P=0.309N | P=0.322N P=0.470N P=0.613N |
|COCHRAN-ARMITAGE | P=0.102N | P=0.272N |
|FISHER EXACT | P=0.660N P=0.122N | P=0.500N P=0.504N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/59 (0%) |
|ADJUSTED (b) | 5.9% 3.7% 0.0% | 0.0% 2.3% 0.0% |
|TERMINAL (d) | 1/24 (4%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 555 729 (T) --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.235N P=0.477N P=0.380N | P=0.678 P=0.530 (e) |
|INCIDENTAL TUMOR | P=0.228N P=0.515N P=0.353N | P=0.678 P=0.530 (e) |
|LOGISTIC REGRESSION | P=0.169N P=0.499N P=0.258N | P=0.678 P=0.530 (e) |
|COCHRAN-ARMITAGE | P=0.142N | P=0.728 |
|FISHER EXACT | P=0.500N P=0.248N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% | 4.8% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/27 (0%) 0/9 (0%) | 1/37 (3%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 649 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.360N P=0.477N P=0.695N | P=0.124N P=0.210N P=0.346N |
|INCIDENTAL TUMOR | P=0.360N P=0.477N P=0.695N | P=0.085N P=0.212N P=0.238N |
|LOGISTIC REGRESSION | P=0.360N P=0.477N P=0.695N | P=0.106N P=0.232N P=0.296N |
|COCHRAN-ARMITAGE | P=0.270N | P=0.097N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.248N P=0.252N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 3/59 (5%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.5% 2.3% 11.2% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 1/37 (3%) 1/43 (2%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 488 729 (T) 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.248 P=0.457N P=0.319 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.445 P=0.498N P=0.569 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.389 P=0.562N P=0.472 |
|COCHRAN-ARMITAGE | (e) | P=0.393 |
|FISHER EXACT | (e) (e) | P=0.500N P=0.492 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) | 4/60 (7%) 1/60 (2%) 3/59 (5%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% | 9.1% 2.3% 11.2% |
|TERMINAL (d) | 1/24 (4%) 0/27 (0%) 0/9 (0%) | 2/37 (5%) 1/43 (2%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 488 729 (T) 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.360N P=0.477N P=0.695N | P=0.590 P=0.147N P=0.581 |
|INCIDENTAL TUMOR | P=0.360N P=0.477N P=0.695N | P=0.366N P=0.167N P=0.445N |
|LOGISTIC REGRESSION | P=0.360N P=0.477N P=0.695N | P=0.439N P=0.203N P=0.565N |
|COCHRAN-ARMITAGE | P=0.270N | P=0.420N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.182N P=0.509N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) | 20/60 (33%) 11/60 (18%) 8/59 (14%) |
|ADJUSTED (b) | 8.3% 0.0% 0.0% | 47.0% 24.9% 27.3% |
|TERMINAL (d) | 2/24 (8%) 0/27 (0%) 0/9 (0%) | 15/37 (41%) 10/43 (23%) 4/21 (19%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 575 719 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.154N P=0.212N P=0.471N | P=0.080N P=0.016N* P=0.179N |
|INCIDENTAL TUMOR | P=0.154N P=0.212N P=0.471N | P=0.030N* P=0.022N* P=0.059N |
|LOGISTIC REGRESSION | P=0.154N P=0.212N P=0.471N | P=0.030N* P=0.017N* P=0.060N |
|COCHRAN-ARMITAGE | P=0.096N | P=0.006N** |
|FISHER EXACT | P=0.248N P=0.248N | P=0.047N* P=0.009N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 0/60 (0%) | 21/60 (35%) 11/60 (18%) 8/59 (14%) |
|ADJUSTED (b) | 12.5% 0.0% 0.0% | 48.1% 24.9% 27.3% |
|TERMINAL (d) | 3/24 (13%) 0/27 (0%) 0/9 (0%) | 15/37 (41%) 10/43 (23%) 4/21 (19%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 575 719 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070N P=0.099N P=0.335N | P=0.056N P=0.010N* P=0.141N |
|INCIDENTAL TUMOR | P=0.070N P=0.099N P=0.335N | P=0.017N* P=0.013N* P=0.034N* |
|LOGISTIC REGRESSION | P=0.070N P=0.099N P=0.335N | P=0.018N* P=0.011N* P=0.040N* |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.003N** |
|FISHER EXACT | P=0.122N P=0.122N | P=0.031N* P=0.006N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 0/60 (0%) | 22/60 (37%) 12/60 (20%) 11/59 (19%) |
|ADJUSTED (b) | 12.5% 0.0% 0.0% | 49.1% 27.1% 36.2% |
|TERMINAL (d) | 3/24 (13%) 0/27 (0%) 0/9 (0%) | 15/37 (41%) 11/43 (26%) 5/21 (24%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 488 719 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070N P=0.099N P=0.335N | P=0.179N P=0.011N* P=0.326N |
|INCIDENTAL TUMOR | P=0.070N P=0.099N P=0.335N | P=0.048N* P=0.016N* P=0.074N |
|LOGISTIC REGRESSION | P=0.070N P=0.099N P=0.335N | P=0.058N P=0.015N* P=0.101N |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.015N* |
|FISHER EXACT | P=0.122N P=0.122N | P=0.034N* P=0.023N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/59 (39%) 23/60 (38%) 15/60 (25%) | 35/60 (58%) 27/60 (45%) 17/59 (29%) |
|ADJUSTED (b) | 65.2% 58.7% 56.9% | 73.9% 52.2% 60.1% |
|TERMINAL (d) | 13/24 (54%) 13/27 (48%) 2/9 (22%) | 25/37 (68%) 19/43 (44%) 11/21 (52%) |
|FIRST INCIDENCE (DAYS) | 495 502 432 | 429 453 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206 P=0.428N P=0.156 | P=0.124N P=0.030N* P=0.225N |
|INCIDENTAL TUMOR | P=0.199N P=0.452N P=0.198N | P=0.008N** P=0.049N* P=0.014N* |
|LOGISTIC REGRESSION | P=0.270N P=0.536N P=0.359N | P=0.010N* P=0.056N P=0.020N* |
|COCHRAN-ARMITAGE | P=0.065N | P<0.001N** |
|FISHER EXACT | P=0.546N P=0.075N | P=0.100N P=0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.9% 2.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 693 684 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.213N P=0.434N P=0.384N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.071N P=0.461N P=0.131N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.172N P=0.482N P=0.316N |
|COCHRAN-ARMITAGE | (e) | P=0.145N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.252N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/59 (39%) 23/60 (38%) 15/60 (25%) | 37/60 (62%) 28/60 (47%) 17/59 (29%) |
|ADJUSTED (b) | 65.2% 58.7% 56.9% | 75.2% 53.2% 60.1% |
|TERMINAL (d) | 13/24 (54%) 13/27 (48%) 2/9 (22%) | 25/37 (68%) 19/43 (44%) 11/21 (52%) |
|FIRST INCIDENCE (DAYS) | 495 502 432 | 429 453 502 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206 P=0.428N P=0.156 | P=0.081N P=0.022N* P=0.161N |
|INCIDENTAL TUMOR | P=0.199N P=0.452N P=0.198N | P=0.002N** P=0.029N* P=0.003N** |
|LOGISTIC REGRESSION | P=0.270N P=0.536N P=0.359N | P=0.004N** P=0.036N* P=0.008N** |
|COCHRAN-ARMITAGE | P=0.065N | P<0.001N** |
|FISHER EXACT | P=0.546N P=0.075N | P=0.071N P<0.001N** |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 6.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 674 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.224N P=0.468N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.118N P=0.233N P=0.327N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.128N P=0.230N P=0.373N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096N | (e) |
|FISHER EXACT | P=0.248N P=0.248N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 8.7% 0.0% 7.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 633 --- 563 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.596N P=0.112N P=0.583 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.442N P=0.141N P=0.579N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.432N P=0.120N P=0.597N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.391N | (e) |
|FISHER EXACT | P=0.122N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 7.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 633 --- 563 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250 P=0.487N P=0.347 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.360 P=0.573N P=0.494 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.370 P=0.500N P=0.491 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.361 | (e) |
|FISHER EXACT | P=0.500N P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 8.3% 3.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/24 (8%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264N P=0.459N P=0.471N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.264N P=0.459N P=0.471N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.264N P=0.459N P=0.471N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.248N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 2/60 (3%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 18.1% 7.4% 10.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/24 (13%) 2/27 (7%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 300 729 (T) 563 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423N P=0.113N P=0.595N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.231N P=0.131N P=0.312N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.194N P=0.136N P=0.269N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.170N | (e) |
|FISHER EXACT | P=0.136N P=0.245N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 5/60 (8%) 2/60 (3%) | 4/60 (7%) 1/60 (2%) 1/59 (2%) |
|ADJUSTED (b) | 6.6% 14.6% 11.2% | 10.0% 2.3% 3.4% |
|TERMINAL (d) | 1/24 (4%) 2/27 (7%) 0/9 (0%) | 3/37 (8%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 658 640 617 | 596 729 (T) 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251 P=0.267 P=0.412 | P=0.179N P=0.141N P=0.347N |
|INCIDENTAL TUMOR | P=0.472 P=0.209 P=0.624 | P=0.154N P=0.176N P=0.279N |
|LOGISTIC REGRESSION | P=0.405 P=0.227 P=0.577 | P=0.136N P=0.159N P=0.263N |
|COCHRAN-ARMITAGE | P=0.583 | P=0.105N |
|FISHER EXACT | P=0.219 P=0.691N | P=0.182N P=0.187N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 5/60 (8%) 3/60 (5%) | 5/60 (8%) 1/60 (2%) 1/59 (2%) |
|ADJUSTED (b) | 6.6% 14.6% 21.1% | 11.5% 2.3% 3.4% |
|TERMINAL (d) | 1/24 (4%) 2/27 (7%) 1/9 (11%) | 3/37 (8%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 658 640 617 | 352 729 (T) 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.116 P=0.267 P=0.180 | P=0.094N P=0.080N P=0.229N |
|INCIDENTAL TUMOR | P=0.280 P=0.209 P=0.345 | P=0.047N* P=0.176N P=0.112N |
|LOGISTIC REGRESSION | P=0.224 P=0.227 P=0.310 | P=0.044N* P=0.142N P=0.110N |
|COCHRAN-ARMITAGE | P=0.421 | P=0.051N |
|FISHER EXACT | P=0.219 P=0.500 | P=0.103N P=0.107N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 569 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 (e) P=0.168 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.105 (e) P=0.242 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.101 (e) P=0.235 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096 | (e) |
|FISHER EXACT | (e) P=0.248 | (e) (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 52/60 (87%) 51/60 (85%) 44/60 (73%) | |
|ADJUSTED (b) | 100.0% 96.2% 100.0% | |
|TERMINAL (d) | 24/24 (100%) 25/27 (93%) 9/9 (100%) | |
|FIRST INCIDENCE (DAYS) | 495 437 341 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.271N P=0.001 ** | |
|INCIDENTAL TUMOR | P=0.408 P=0.575N P=0.458 | |
|LOGISTIC REGRESSION | P=0.425 P=0.532N P=0.530 | |
|COCHRAN-ARMITAGE | P=0.038N* | |
|FISHER EXACT | P=0.500N P=0.054N | |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/57 (5%) 7/58 (12%) 3/59 (5%) | 3/60 (5%) 3/60 (5%) 3/56 (5%) |
|ADJUSTED (b) | 11.5% 23.9% 23.6% | 8.1% 6.8% 14.3% |
|TERMINAL (d) | 2/23 (9%) 5/26 (19%) 2/9 (22%) | 3/37 (8%) 2/43 (5%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 694 648 341 | 729 (T) 728 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.168 P=0.207 P=0.277 | P=0.334 P=0.587N P=0.385 |
|INCIDENTAL TUMOR | P=0.344 P=0.187 P=0.482 | P=0.389 P=0.595N P=0.385 |
|LOGISTIC REGRESSION | P=0.242 P=0.191 P=0.578 | P=0.333 P=0.568N P=0.385 |
|COCHRAN-ARMITAGE | P=0.549N | P=0.550 |
|FISHER EXACT | P=0.168 P=0.644N | P=0.660N P=0.627 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 1/58 (2%) 0/59 (0%) | 3/60 (5%) 1/60 (2%) 0/56 (0%) |
|ADJUSTED (b) | 0.0% 3.8% 0.0% | 7.3% 2.3% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/26 (4%) 0/9 (0%) | 2/37 (5%) 1/43 (2%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | 578 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.644 P=0.524 (e) | P=0.096N P=0.260N P=0.216N |
|INCIDENTAL TUMOR | P=0.644 P=0.524 (e) | P=0.108N P=0.313N P=0.221N |
|LOGISTIC REGRESSION | P=0.644 P=0.524 (e) | P=0.077N P=0.296N P=0.165N |
|COCHRAN-ARMITAGE | P=0.726N | P=0.067N |
|FISHER EXACT | P=0.504 (e) | P=0.309N P=0.135N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/57 (5%) 8/58 (14%) 3/59 (5%) | 6/60 (10%) 4/60 (7%) 3/56 (5%) |
|ADJUSTED (b) | 11.5% 27.5% 23.6% | 15.2% 9.0% 14.3% |
|TERMINAL (d) | 2/23 (9%) 6/26 (23%) 2/9 (22%) | 5/37 (14%) 3/43 (7%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 694 648 341 | 578 728 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.151 P=0.139 P=0.277 | P=0.420N P=0.283N P=0.550N |
|INCIDENTAL TUMOR | P=0.314 P=0.123 P=0.482 | P=0.382N P=0.324N P=0.554N |
|LOGISTIC REGRESSION | P=0.216 P=0.126 P=0.578 | P=0.362N P=0.300N P=0.474N |
|COCHRAN-ARMITAGE | P=0.546N | P=0.217N |
|FISHER EXACT | P=0.107 P=0.644N | P=0.372N P=0.281N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 12/60 (20%) 20/60 (33%) 11/59 (19%) |
|ADJUSTED (b) | | 29.9% 42.8% 36.9% |
|TERMINAL (d) | | 10/37 (27%) 17/43 (40%) 5/21 (24%) |
|FIRST INCIDENCE (DAYS) | | 578 540 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.138 P=0.164 P=0.207 |
|INCIDENTAL TUMOR | | P=0.301 P=0.106 P=0.423 |
|LOGISTIC REGRESSION | | P=0.343 P=0.119 P=0.423 |
|COCHRAN-ARMITAGE | | P=0.478N |
|FISHER EXACT | | P=0.074 P=0.518N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 12/60 (20%) 20/60 (33%) 12/59 (20%) |
|ADJUSTED (b) | | 29.9% 42.8% 40.9% |
|TERMINAL (d) | | 10/37 (27%) 17/43 (40%) 6/21 (29%) |
|FIRST INCIDENCE (DAYS) | | 578 540 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.088 P=0.164 P=0.135 |
|INCIDENTAL TUMOR | | P=0.217 P=0.106 P=0.310 |
|LOGISTIC REGRESSION | | P=0.256 P=0.119 P=0.316 |
|COCHRAN-ARMITAGE | | P=0.522 |
|FISHER EXACT | | P=0.074 P=0.572 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 7.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 627 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.060N P=0.110N P=0.240N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.044N* P=0.170N P=0.124N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.038N* P=0.121N P=0.148N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.037N* | (e) |
|FISHER EXACT | P=0.122N P=0.122N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 7.6% 3.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 1/27 (4%) 0/9 (0%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 627 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115N P=0.276N P=0.240N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.084N P=0.367N P=0.124N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.077N P=0.304N P=0.148N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.061N | (e) |
|FISHER EXACT | P=0.309N P=0.122N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 33/60 (55%) 28/60 (47%) 14/60 (23%) | 16/60 (27%) 18/60 (30%) 11/59 (19%) |
|ADJUSTED (b) | 69.0% 60.3% 57.7% | 36.1% 35.0% 31.5% |
|TERMINAL (d) | 10/24 (42%) 10/27 (37%) 2/9 (22%) | 10/37 (27%) 11/43 (26%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 520 226 474 | 457 540 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306N P=0.188N P=0.433N | P=0.454 P=0.531N P=0.498 |
|INCIDENTAL TUMOR | P<0.001N** P=0.261N P=0.001N** | P=0.230N P=0.491 P=0.248N |
|LOGISTIC REGRESSION | P=0.003N** P=0.229N P=0.009N** | P=0.300N P=0.466 P=0.339N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.185N |
|FISHER EXACT | P=0.233N P<0.001N** | P=0.420 P=0.205N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 2.0% 4.7% 13.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 1/9 (11%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 590 632 466 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.216 P=0.519 P=0.329 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.415 P=0.408 P=0.511 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.406 P=0.499 P=0.536 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.391 | (e) |
|FISHER EXACT | P=0.500 P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 13.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 1/9 (11%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 579 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * (e) P=0.112 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.054 (e) P=0.132 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.074 (e) P=0.181 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096 | (e) |
|FISHER EXACT | (e) P=0.248 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 13.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/27 (0%) 1/9 (11%) | 0/37 (0%) 0/43 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 579 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * (e) P=0.112 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.054 (e) P=0.132 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.074 (e) P=0.181 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096 | (e) |
|FISHER EXACT | (e) P=0.248 | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 58/60 (97%) 57/60 (95%) 49/60 (82%) | 47/60 (78%) 44/60 (73%) 34/59 (58%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 90.3% 79.7% 88.4% |
|TERMINAL (d) | 24/24 (100%) 27/27 (100%) 9/9 (100%) | 32/37 (86%) 32/43 (74%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 300 437 341 | 429 453 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.272N P=0.001 ** | P=0.247 P=0.083N P=0.201 |
|INCIDENTAL TUMOR | P=0.240N P=0.516N P=0.286N | P=0.096N P=0.153N P=0.132N |
|LOGISTIC REGRESSION | P=0.237N P=0.614N P=0.304N | P=0.154N P=0.175N P=0.220N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.009N** |
|FISHER EXACT | P=0.500N P=0.008N** | P=0.335N P=0.013N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 G/KG 5 MG/KG 10 MG/KG | 0 G/KG 5 MG/KG 10MG/KG |
| | VEHICLEM LOW MALE HIGHMALE | VEHICLEF LOW FEMA HIGH FEM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 33/60 (55%) 23/60 (38%) | 25/60 (42%) 27/60 (45%) 16/59 (27%) |
|ADJUSTED (b) | 77.6% 68.7% 80.7% | 49.9% 49.4% 43.8% |
|TERMINAL (d) | 13/24 (54%) 13/27 (48%) 5/9 (56%) | 13/37 (35%) 16/43 (37%) 4/21 (19%) |
|FIRST INCIDENCE (DAYS) | 520 226 466 | 352 453 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403 P=0.125N P=0.297 | P=0.532N P=0.448N P=0.552N |
|INCIDENTAL TUMOR | P=0.005N** P=0.159N P=0.014N* | P=0.059N P=0.396 P=0.070N |
|LOGISTIC REGRESSION | P=0.014N* P=0.128N P=0.020N* | P=0.092N P=0.379 P=0.084N |
|COCHRAN-ARMITAGE | P=0.001N** | P=0.063N |
|FISHER EXACT | P=0.131N P=0.002N** | P=0.427 P=0.070N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 59/60 (98%) 58/60 (97%) 50/60 (83%) | 53/60 (88%) 54/60 (90%) 39/59 (66%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.0% 90.0% 90.3% |
|TERMINAL (d) | 24/24 (100%) 27/27 (100%) 9/9 (100%) | 33/37 (89%) 37/43 (86%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 300 226 341 | 352 453 449 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.274N P=0.001 ** | P=0.189 P=0.192N P=0.183 |
|INCIDENTAL TUMOR | P=0.126N P=0.566N P=0.219N | P=0.017N* P=0.577N P=0.034N* |
|LOGISTIC REGRESSION | P=0.040N* P=0.570N P=0.116N | P=0.041N* P=0.561N P=0.118N |
|COCHRAN-ARMITAGE | P=0.001N** | P=0.001N** |
|FISHER EXACT | P=0.500N P=0.004N** | P=0.500 P=0.003N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05026 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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