TR 389 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05026 SODIUM AZIDE TIME: 07:56:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 06462
CONT: N01C09565001 CAS: 26628228
PATHOLOGIST: G. PARKER
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/04/94
EXP: 05026 SODIUM AZIDE TIME: 07:56:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 06462
CONT: N01C09565001 CAS: 26628228
PATHOLOGIST: G. PARKER
SODIUM AZIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 G/KG VEHICLEM |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 35 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 151 300 495 495 520 549 555 561 568 572 |
| 589 590 603 604 627 633 640 652 654 658 |
| 674 678 681 681 690 693 694 694 695 697 |
| 703 703 711 719 727 |
| CENSORED DEATHS |
| 626 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 MG/KG LOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 2 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 226 403 437 502 516 529 547 576 579 589 |
| 591 632 639 640 641 648 659 660 673 681 |
| 683 690 690 693 698 702 704 708 712 717 |
| 723 |
| CENSORED DEATHS |
| 227 716 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KGHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 9 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 220 348 414 415 415 432 432 466 474 512 |
| 543 557 557 563 563 569 579 591 596 607 |
| 617 637 640 645 645 648 649 650 654 659 |
| 662 662 662 667 667 669 670 677 677 677 |
| 681 719 |
| CENSORED DEATHS |
| 233 235 332 339 341 341 341 526 701 |
| |
==================================================================================
SODIUM AZIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 98.3 98.3 96.7 96.7 96.7 91.7 76.7 66.4 40.9 |
|G/KG VEHIC|EM |
| | |
|5 MG/KG LOW| 100.0 100.0 98.3 98.3 96.6 94.9 89.9 81.4 69.5 47.4 |
| | |
| | |
|10 | 100.0 100.0 98.3 96.4 90.8 83.2 79.4 63.9 36.8 19.2 |
|MG/KGHIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 5 MG/KG LOW 10 |
| G/KG VEHICLEM MG/KGHIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.9% 47.4% 19.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.003 P=0.555N P=0.002 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.0 615.7 580.6 |
|NATURAL DEATHS (C) | (20.0) (19.8) (16.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.6 661.9 572.3 |
|(STANDARD ERROR) | (13.7) (14.5) (18.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM AZIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 G/KG VEHICLEF |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 306 316 352 429 457 488 496 569 575 578 |
| 594 596 603 643 649 671 680 684 693 699 |
| 705 714 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 MG/KG LOW A |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 453 502 540 549 603 604 628 648 670 684 |
| 695 705 719 721 722 728 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10MG/KG HIGH |
| ---------------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 33 CENSORED DEATHS 5 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 106 141 152 201 206 395 449 468 488 495 |
| 502 502 516 549 569 610 612 642 646 646 |
| 646 647 649 650 653 654 654 659 660 667 |
| 688 691 705 |
| CENSORED DEATHS |
| 103 104 108 108 109 |
| |
==================================================================================
SODIUM AZIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 95.0 95.0 91.7 88.3 78.3 75.0 61.7 |
|G/KG VEHIC|EF |
| | |
|5 | 100.0 100.0 100.0 100.0 100.0 98.3 95.0 90.0 86.7 71.7 |
|MG/KG LOW | A |
| | |
|10MG/KG | 100.0 94.5 90.8 90.8 89.0 85.3 76.0 72.3 46.3 38.9 |
|HIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 5 10MG/KG |
| G/KG VEHICLEF MG/KG LOW A HIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.7% 71.7% 38.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.010 P=0.223N P=0.015 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 574.6 641.1 530.8 |
|NATURAL DEATHS (C) | (27.0) (21.0) (30.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 669.8 704.1 565.4 |
|(STANDARD ERROR) | (14.1) ( 7.8) (27.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM AZIDE
KAPLAN-MEIER SURVIVAL CURVES
0 G/KG VEHICLEM = 1
5 MG/KG LOW = 2
10 MG/KGHIGH = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 32
| 1 32 1 3 2 3 2 1
| 2 2
| 12 2 12 1
90 + 3 3 2 11
| 3 3 21112
| 33 2 2
| 3 3 3 1 1 2
P 80 + 3 3 1 1 22
E | 1 1
R | 33 1122
C | 33 1121 2
E 70 + 33 2 2
N | 3 3 1 12
T | 333 22
| 3 3 11
S 60 + 3 3 112
U | 33 22
R | 33 1122
V |
I 50 + 11222
V | 33 2 2
A | 3 3 111
L | 11
40 + 1 1
| 33
|
|
30 + 33
|
|
| 33 3
20 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
SODIUM AZIDE
KAPLAN-MEIER SURVIVAL CURVES
0 G/KG VEHICLEF = 1
5 MG/KG LOW A = 2
10MG/KG HIGH = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
| 3 33 1 1 1 2 2 2
| 3 3 1 1 22
| 33 1 1 1 2 2
90 + 3 3 3 11 2 2
| 3 3 1 11 2 2 2
P | 3 3 2 2
E | 333 1 11 2 22
R 80 + 11 2 2
C | 3 3 1 11 22
E | 3 3 3 1 1
N | 3 3 1 1 2 2
T 70 + 11
| 3 33 111
S | 11
U | 11 1
R 60 +
V |
I | 33
V |
A 50 + 3 3
L | 33
| 3 3
|
40 + 3 3 3
|
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
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