TR 391 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIS (2-CHLOROETHYL) PHOSPHATE
NTP Experiment-Test: 05042-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 16:28:50
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 175MG/KG 350MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 9 10 10
Early Deaths
Moribund 7 5 5
Dead 6 6 8
Gavage Death 5 2 2
Accident 1
Dosing Accident 1
Survivors
Terminal Sacrifice 31 37 35
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (13) (49)
Periesophageal Tissue, Foreign Body 1 (2%)
Periesophageal Tissue, Inflammation, Acute 3 (6%)
Wall, Inflammation, Necrotizing 1 (2%)
Intestine Small, Ileum (43) (9) (46)
Hyperplasia, Lymphoid 2 (5%)
Intestine Small, Jejunum (45) (12) (46)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus 1 (2%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Subacute 2 (4%)
Necrosis, Coagulative 3 (6%) 4 (8%)
Vacuolization Cytoplasmic 3 (6%) 4 (8%) 1 (2%)
Mesentery (7) (9) (9)
Infiltration Cellular, Mast Cell 1 (14%)
Fat, Necrosis 3 (43%) 8 (89%) 8 (89%)
Pancreas (49) (13) (48)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 4 (8%) 2 (15%) 6 (13%)
Acinus, Basophilic Focus 1 (2%) 1 (8%) 1 (2%)
Acinus, Necrosis, Coagulative 1 (2%)
Duct, Ectasia 1 (8%)
Salivary Glands (50) (13) (48)
Inflammation, Chronic 8 (16%) 1 (8%) 5 (10%)
Stomach, Forestomach (49) (49) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 175MG/KG 350MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia, Squamous 4 (8%) 1 (2%) 8 (17%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute 1 (2%)
Stomach, Glandular (48) (49) (47)
Infiltration Cellular, Mast Cell 1 (2%)
Mucosa, Dilatation 1 (2%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tooth (49) (13) (50)
Inflammation, Acute 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (49)
Inflammation, Chronic 1 (8%)
Inflammation, Subacute 1 (2%)
Atrium, Thrombosis 1 (8%)
Epicardium, Inflammation, Acute 4 (8%) 1 (8%)
Myocardium, Necrosis, Zenkers 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (12) (50)
Atrophy 1 (2%)
Degeneration, Ballooning 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hypertrophy, Focal 1 (2%)
Adrenal Gland, Medulla (49) (12) (48)
Hyperplasia 2 (4%)
Pituitary Gland (48) (14) (44)
Pars Distalis, Angiectasis 4 (8%) 4 (9%)
Pars Distalis, Hyperplasia 6 (13%) 1 (7%) 5 (11%)
Pars Distalis, Hypertrophy, Focal 1 (2%)
Thyroid Gland (50) (12) (49)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%)
Follicle, Cyst 1 (8%)
Follicular Cell, Hyperplasia 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 175MG/KG 350MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (37) (16) (35)
Cyst 14 (38%) 6 (38%) 7 (20%)
Periovarian Tissue, Inflammation, Chronic 1 (3%)
Uterus (50) (43) (50)
Hydrometra 1 (2%)
Inflammation, Chronic 1 (2%)
Endometrium, Hyperplasia, Cystic 49 (98%) 42 (98%) 48 (96%)
Endometrium, Inflammation, Acute 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (13) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 12 (24%) 14 (28%)
Lymph Node (49) (17) (50)
Iliac, Hemorrhage 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Inguinal, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (6%) 1 (2%)
Lymph Node, Mandibular (47) (12) (47)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mesenteric (45) (16) (48)
Ectasia 1 (2%)
Hematopoietic Cell Proliferation 1 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Inflammation, Chronic 1 (6%)
Spleen (50) (20) (48)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 5 (25%) 5 (10%)
Hyperplasia, Lymphoid 2 (4%) 3 (15%) 6 (13%)
Hyperplasia, Plasma Cell 1 (2%)
Thymus (45) (8) (40)
Cyst 1 (2%) 3 (8%)
Hyperplasia, Lymphoid 1 (2%) 1 (3%)
Mediastinum, Foreign Body 1 (2%)
Mediastinum, Inflammation, Acute 3 (7%) 1 (13%)
Thymocyte, Necrosis 1 (2%) 1 (13%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 175MG/KG 350MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (33) (45)
Hyperplasia, Cystic 3 (6%) 3 (9%) 5 (11%)
Duct, Ectasia 1 (2%)
Duct, Hyperplasia 1 (3%) 1 (2%)
Skin (50) (48) (50)
Fibrosis 1 (2%)
Foreign Body 1 (2%)
Inflammation, Acute 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Face, Inflammation, Acute 2 (4%)
Subcutaneous Tissue, Abscess 2 (4%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (49) (14) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Head, Inflammation, Acute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (49)
Hemorrhage 1 (2%)
Necrosis, Liquifactive 1 (8%)
Meninges, Inflammation, Chronic 1 (2%) 1 (2%)
Thalamus, Inflammation 1 (2%)
Thalamus, Mineralization 21 (42%) 6 (46%) 23 (47%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Congestion 2 (4%) 1 (2%) 1 (2%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 4 (8%) 2 (4%)
Leukocytosis 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%)
Alveolus, Foreign Body 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 175MG/KG 350MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Arteriole, Hyperplasia 1 (2%)
Fat, Mediastinum, Necrosis 1 (2%)
Mediastinum, Foreign Body 4 (8%) 1 (2%) 3 (6%)
Mediastinum, Inflammation, Acute 2 (4%) 1 (2%) 2 (4%)
Mediastinum, Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Acute 2 (4%) 1 (2%)
Nose (49) (14) (50)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (7%) 1 (2%)
Respiratory Epithelium, Inflammation, Acute 1 (2%)
Trachea (50) (12) (50)
Glands, Dilatation 1 (2%)
Peritracheal Tissue, Foreign Body 2 (4%) 1 (8%)
Peritracheal Tissue, Inflammation, Acute 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (49) (49) (49)
Hyperplasia 1 (2%) 4 (8%) 2 (4%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50)
Infarct 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 8 (16%) 1 (2%) 9 (18%)
Cortex, Necrosis, Coagulative 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Medulla, Inflammation, Acute 1 (2%)
Renal Tubule, Karyomegaly 5 (10%) 44 (88%)
Urinary Bladder (49) (12) (49)
Inflammation, Chronic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 8 10 8
Early Deaths
Moribund 10 8 12
Dead 14 13 9
Dosing Accident 1 1 2
Gavage Death 2 3 3
Survivors
Terminal Sacrifice 25 25 25
Missing 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (23) (50)
Perforation 1 (2%)
Periesophageal Tissue, Foreign Body 1 (2%) 3 (13%) 1 (2%)
Periesophageal Tissue, Inflammation, Acute 3 (6%) 3 (13%) 1 (2%)
Periesophageal Tissue, Inflammation, Chronic 2 (9%)
Periesophageal Tissue, Inflammation,
Granulomatous 1 (2%) 1 (4%)
Intestine Large, Cecum (47) (25) (46)
Inflammation, Acute 1 (2%)
Intestine Large, Colon (49) (26) (47)
Inflammation, Acute 1 (4%)
Intestine Small, Duodenum (16) (7) (11)
Inflammation, Chronic 1 (14%)
Inflammation, Necrotizing 1 (9%)
Intestine Small, Ileum (43) (23) (41)
Hyperplasia, Lymphoid 1 (4%)
Intestine Small, Jejunum (45) (23) (44)
Ulcer 1 (2%)
Liver (50) (50) (50)
Amyloid Deposition 1 (2%)
Angiectasis 2 (4%)
Basophilic Focus 1 (2%) 2 (4%) 1 (2%)
Clear Cell Focus 4 (8%) 1 (2%) 5 (10%)
Cytomegaly 1 (2%)
Eosinophilic Focus 3 (6%) 8 (16%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hyperplasia, Chronic, Lymphoid 1 (2%)
Inflammation, Subacute 1 (2%)
Mitotic Alteration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mixed Cell Focus 2 (4%) 1 (2%)
Necrosis, Coagulative 2 (4%) 4 (8%) 4 (8%)
Vacuolization Cytoplasmic 4 (8%) 2 (4%) 4 (8%)
Mesentery (9) (2) (4)
Hemorrhage 1 (25%)
Inflammation, Acute 1 (11%)
Fat, Necrosis 5 (56%) 2 (100%) 1 (25%)
Pancreas (49) (26) (49)
Inflammation, Acute 1 (2%)
Acinus, Atrophy 10 (20%) 3 (12%) 8 (16%)
Acinus, Basophilic Focus 1 (2%)
Acinus, Hyperplasia 1 (2%)
Acinus, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Salivary Glands (49) (24) (49)
Inflammation, Chronic 8 (16%) 1 (4%) 13 (27%)
Stomach, Forestomach (49) (50) (49)
Hyperplasia 1 (2%)
Hyperplasia, Squamous 2 (4%) 3 (6%) 6 (12%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute 2 (4%)
Ulcer 1 (2%)
Stomach, Glandular (50) (47) (47)
Inflammation, Acute 2 (4%) 2 (4%)
Mucosa, Dilatation 1 (2%) 1 (2%) 1 (2%)
Tooth (50) (25) (49)
Dysplasia 21 (42%) 6 (24%) 18 (37%)
Inflammation, Acute 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (25) (50)
Inflammation, Acute 1 (2%)
Inflammation, Subacute 1 (2%) 2 (4%)
Mineralization 1 (4%)
Atrium, Thrombosis 1 (2%) 1 (4%) 2 (4%)
Myocardium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (23) (48)
Atrophy 1 (2%) 4 (8%)
Degeneration, Ballooning 4 (8%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (4%)
Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy, Focal 2 (4%)
Spindle Cell, Hyperplasia 1 (4%)
Adrenal Gland, Medulla (46) (23) (43)
Hyperplasia 1 (4%) 1 (2%)
Pituitary Gland (45) (22) (48)
Pars Distalis, Cyst 1 (2%)
Thyroid Gland (49) (23) (49)
Inflammation, Acute 1 (2%)
Ultimobranchial Cyst 1 (4%) 1 (2%)
Follicle, Cyst 1 (4%)
Follicular Cell, Hyperplasia 3 (6%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (7) (3) (5)
Inflammation, Chronic 6 (86%) 2 (40%)
Prostate (49) (23) (47)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Seminal Vesicle (48) (26) (50)
Concretion 1 (4%)
Inflammation, Chronic 1 (2%)
Testes (50) (24) (50)
Interstitial Cell, Hyperplasia 2 (4%)
Seminiferous Tubule, Atrophy 1 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (25) (49)
Atrophy 2 (4%)
Lymph Node (50) (27) (49)
Mediastinal, Inflammation, Acute 1 (4%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (46) (22) (44)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (48) (24) (44)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thrombosis 1 (2%)
Spleen (50) (28) (49)
Amyloid Deposition 1 (4%)
Angiectasis 1 (2%)
Atrophy 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 4 (14%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 2 (7%) 1 (2%)
Thymus (29) (17) (33)
Cyst 3 (10%) 2 (6%)
Thymocyte, Necrosis 3 (18%) 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (35) (49)
Acanthosis 1 (2%) 1 (3%) 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation 1 (2%) 1 (2%)
Inflammation, Acute 2 (4%) 2 (6%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (3%) 4 (8%)
Pigmentation 1 (2%)
Face, Foreign Body 1 (2%)
Face, Inflammation, Acute 1 (2%) 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%) 2 (6%) 2 (4%)
Subcutaneous Tissue, Foreign Body 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (25) (49)
Fracture Healed 1 (2%)
Tibia, Hyperostosis 1 (4%)
Skeletal Muscle (50) (25) (50)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Head, Inflammation, Acute 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (25) (50)
Meninges, Inflammation, Chronic 1 (2%)
Thalamus, Mineralization 17 (34%) 14 (56%) 26 (52%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 3 (6%) 1 (2%) 2 (4%)
Edema 1 (2%)
Foreign Body 2 (4%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 3 (6%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 3 (6%) 3 (6%)
Alveolus, Foreign Body 3 (6%)
Alveolus, Infiltration Cellular 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 5 (10%) 3 (6%)
Mediastinum, Foreign Body 5 (10%) 2 (4%) 3 (6%)
Mediastinum, Inflammation, Acute 5 (10%) 2 (4%) 5 (10%)
Pleura, Foreign Body 1 (2%)
Pleura, Inflammation, Acute 3 (6%) 2 (4%)
Pleura, Inflammation, Granulomatous 2 (4%) 1 (2%)
Nose (50) (25) (50)
Foreign Body 1 (2%) 1 (4%)
Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%)
Trachea (49) (24) (49)
Peritracheal Tissue, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1)
Inflammation, Acute 1 (100%)
Middle Ear, Inflammation, Acute 1 (50%)
Pinna, Hyperplasia 1 (100%)
Eye (6) (5) (7)
Lens, Cataract 1 (20%) 1 (14%)
Harderian Gland (48) (49) (47)
Hyperplasia 3 (6%) 3 (6%) 5 (11%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Amyloid Deposition 1 (2%)
Infarct 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 2 (4%) 5 (10%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05042-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 16:28:50
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 175MG/KG 350MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 9 (18%) 7 (14%) 13 (26%)
Glomerulus, Dilatation 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 3 (6%) 1 (2%)
Proximal Convoluted Renal Tubule, Dilatation 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Karyomegaly 2 (4%) 16 (32%) 39 (78%)
Renal Tubule, Necrosis, Coagulative 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (50) (24) (49)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Chronic 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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