TR 391 Mouse Pathology Tables
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + A + + + + A + + + + + + + + M +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M M M M M M M A M M + M A M M + A M + M + M M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + M + + + + + M M M + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M M + + M M + + + + + M M + M + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +|
Fibroadenoma | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Squamous Cell Carcinoma, Metastatic, | |
Ear | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Squamous Cell Carcinoma| |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + M + + + A + + + + M A + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + A + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M A M M + M A M M M A M M + M M A + M M M M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + A + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + + + + + M + M + + + M +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M M + + + M + + + + + + + + + + M + + + M + + +|
Lymphoma Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + M + + + + + + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Ear | X|
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
External Ear, Squamous Cell Carcinoma| X|
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 41 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 3 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
__________________________________________________________________________|____________|
Tooth | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 49 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Adenoma | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 37 |
Lymphoma Malignant Lymphocytic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 45 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________|____________|
Thymus | | 45 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 5 |
Squamous Cell Carcinoma, Metastatic, | | |
Ear | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
External Ear, Squamous Cell Carcinoma| | 1 |
__________________________________________________________________________|____________|
Eye | | 8 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Adenoma | | 3 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M + M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + +|
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + +|
Fibrosarcoma, Metastatic, Skin | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + M +|
Cystadenoma | |
Lymphoma Malignant Mixed | |
Periovarian Tissue, Mesothelioma | |
Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | X |
Lymphoma Malignant Lymphocytic | |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Inguinal, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Thymus | + M + I +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Trichoepithelioma | |
Subcutaneous Tissue, Fibrosarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Fibrosarcoma, Metastatic, Skin | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + +|
Leukemia | |
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Adenoma, Multiple | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + + A A|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M M M A A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + M + +|
Cystadenoma | X |
Lymphoma Malignant Mixed | X |
Periovarian Tissue, Mesothelioma | |
Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | |
Lymphoma Malignant Lymphocytic | X X |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | |
__________________________________________________________________________|
Spleen | + + + + + M + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Thymus | M + + + M + M +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Mast Cell Tumor Malignant, | |
Metastatic, Spleen | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Leukemia | X |
__________________________________________________________________________|
Trachea | + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Adenoma, Multiple | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 13 |
__________________________________________________________________________|____________|
Gallbladder | | 8 |
__________________________________________________________________________|____________|
Intestine Large | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 11 |
__________________________________________________________________________|____________|
Intestine Small | | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 12 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 2 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 9 |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 13 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | | 13 |
Mast Cell Tumor Malignant, | | |
Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 12 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | | 14 |
Pars Distalis, Adenoma | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | | 12 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 16 |
Cystadenoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Periovarian Tissue, Mesothelioma | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | | 43 |
Deciduoma Benign | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Endometrium, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 13 |
__________________________________________________________________________|____________|
Lymph Node | | 17 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
Mast Cell Tumor Malignant, | | |
Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Spleen | | 20 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | | 8 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 33 |
__________________________________________________________________________|____________|
Skin | | 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Spleen | | 1 |
Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 13 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 14 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | | 14 |
Leukemia | | 1 |
__________________________________________________________________________|____________|
Trachea | | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Adenoma | | 6 |
Adenoma, Multiple | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Lymphoma Malignant Mixed | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 5 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M A + + + A A + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + M M A + M M M A M + M M M M M M M M A M M M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + |
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + I + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + M + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + M + + M + M M + + + + M + + + + M M M +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Cervix, Hemangiosarcoma | |
Endometrium, Adenocarcinoma | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Ear | X |
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + M + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | M + + M + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + M + + M + + + M + + + + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + M + + + + + + + + + + + + +|
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + M + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Squamous Cell Carcinoma, Metastatic, | |
Ear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibrosarcoma | |
Squamous Cell Carcinoma | |
Pinna, Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + A +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M A A M M M M M M M M + M M M M M M + + M A M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + M + M + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + M + + + + + + + + + + + + + + M +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + M + + + + + M M + + + + + + + + + + + M + M|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Cervix, Hemangiosarcoma | X |
Endometrium, Adenocarcinoma | X |
Endometrium, Polyp Stromal | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + M + + +|
Fibrosarcoma, Metastatic, Ear | |
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M + M + + M + + + + + M + M + + + M + + + + + +|
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + M + + + M + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic, | |
Ear | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
Fibrosarcoma | X |
Squamous Cell Carcinoma | X|
Pinna, Fibrosarcoma | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 43 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Adenoma | | 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | | 44 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 35 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Histiocytic Sarcoma | | 1 |
Cervix, Hemangiosarcoma | | 1 |
Endometrium, Adenocarcinoma | | 1 |
Endometrium, Polyp Stromal | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Histiocytic Sarcoma | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Fibrosarcoma, Metastatic, Ear | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | | 48 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | | 40 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | | 3 |
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Alveolar/Bronchiolar Adenoma | | 5 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Ear | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Fibrosarcoma | | 1 |
Squamous Cell Carcinoma | | 1 |
Pinna, Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Adenoma | | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + A M + + A + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + M + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M + M M + A M M M M M + M M + + M A M M + + M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + M + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic | |
Hemangiosarcoma, Metastatic, Spleen | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Lipoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + M + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic | X |
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | M M + + + M + M + + M + + M + + M M + + + + + + M|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M + M M M M + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Adenoma | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Hemangiosarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | M + + + + + + A A A + + + + + + M + + + + M + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M + M + M A M + + + M M M M M M + M M + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + A A|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic | X |
Hemangiosarcoma, Metastatic, Spleen | X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Spleen | |
__________________________________________________________________________|
Mesentery | + |
Lipoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + M + + + M + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic | X |
Hemangiosarcoma, Metastatic, Spleen | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + + + + + + + + M|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + M + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma | |
__________________________________________________________________________|
Thymus | M M M M M M + + M M + + + M + + + + M + M + + M +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + M + M M M M M + M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Hemangiosarcoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
__________________________________________________________________________|____________|
Gallbladder | | 38 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hemangiosarcoma | | 2 |
Hemangiosarcoma, Metastatic | | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Hepatocellular Carcinoma | | 7 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | | 12 |
Hepatocellular Adenoma, Multiple | | 8 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
Sarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 9 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Tooth | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
__________________________________________________________________________|____________|
Prostate | | 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Testes | | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Interstitial Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hemangiosarcoma, Metastatic | | 2 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 46 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hemangiosarcoma | | 3 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | | 29 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 9 |
__________________________________________________________________________|____________|
Skin | | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 7 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 6 |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Adenoma | | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Bilateral, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + M M M + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A M M M A M A M M M M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + M + M +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + M + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma, Multiple | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M M M + M + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Subcutaneous Tissue, Fibroma | X X X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M A M M + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + M M M M + + + M + M|
__________________________________________________________________________|
Intestine Small, Ileum | + A + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + A +|
Adenocarcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M + M M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + M M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Preputial Gland | + |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma, Multiple | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M M + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + + M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M +|
Hemangiosarcoma, Metastatic, Spleen | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X|
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Fibrosarcoma, Metastatic, Skin | X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 23 |
__________________________________________________________________________|____________|
Gallbladder | | 14 |
__________________________________________________________________________|____________|
Intestine Large | | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 26 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 26 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 23 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 23 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hemangiosarcoma | | 4 |
Hepatocellular Carcinoma | | 10 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 7 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 26 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 24 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
__________________________________________________________________________|____________|
Tooth | | 25 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 25 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 23 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 23 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 24 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | | 23 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 26 |
__________________________________________________________________________|____________|
Testes | | 24 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 27 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 22 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 24 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | | 28 |
Hemangioma | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 6 |
__________________________________________________________________________|____________|
Skin | | 35 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Subcutaneous Tissue, Fibroma | | 3 |
Subcutaneous Tissue, Fibrosarcoma | | 4 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | | 25 |
__________________________________________________________________________|____________|
Trachea | | 24 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 5 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Adenoma | | 8 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 24 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + M M + M + M M + M + + + + + + M A + + + M A|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + M + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | M + M A A M M + M M M M M M M M M M + A M M M M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + + + + + + + + + + + + A + + + + A|
Adenocarcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic | |
Adenocarcinoma, Metastatic, | |
Intestine Small | |
Fibrosarcoma, Metastatic, Skin | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Adenocarcinoma, Metastatic, | |
Intestine Small | |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Squamous Cell Papilloma | |
Glandular, Mast Cell Tumor Malignant,| |
Metastatic, Skin | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A|
Adenocarcinoma, Metastatic | |
Adenocarcinoma, Metastatic, | |
Intestine Small | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + M +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + M M M M M M + + M + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + M + + + M + + + + + + + + M M|
__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Thymus | + + + M M + + + + + M + + M M + M + + + + M + M M|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M + M M M M M M + M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | X |
Subcutaneous Tissue, Fibroma, | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Multiple | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | X |
Adenoma, Mild | X |
Adenoma, Multiple | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | X |
Renal Tubule, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + A + + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M + A M M M M M + + + M A M + M M + M M + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + M + + + + + M A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + A + + + + + + + + + +|
Adenocarcinoma | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic | X |
Adenocarcinoma, Metastatic, | |
Intestine Small | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatoblastoma | X|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Adenocarcinoma, Metastatic, | |
Intestine Small | X |
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Glandular, Mast Cell Tumor Malignant,| |
Metastatic, Skin | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic | X |
Adenocarcinoma, Metastatic, | |
Intestine Small | X |
__________________________________________________________________________|
Tooth | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + M + M M + + + + M + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M M + M + M + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + M + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + M M + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Thymus | + + + M + M M M + + + + M M + + + + + M + M + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M + + + M + M M + M M + M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Mast Cell Tumor Malignant | |
Subcutaneous Tissue, Fibroma, | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Multiple | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + + + + + + + + + + + + A + + + + +|
Adenoma | X X |
Adenoma, Mild | |
Adenoma, Multiple | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
Renal Tubule, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 34 |
__________________________________________________________________________|____________|
Intestine Large | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 45 |
__________________________________________________________________________|____________|
Intestine Small | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 41 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 44 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Liver | | 50 |
Adenocarcinoma, Metastatic | | 1 |
Adenocarcinoma, Metastatic, | | |
Intestine Small | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | | 8 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 17 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Adenocarcinoma, Metastatic, | | |
Intestine Small | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Squamous Cell Papilloma | | 1 |
Glandular, Mast Cell Tumor Malignant,| | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
Adenocarcinoma, Metastatic | | 1 |
Adenocarcinoma, Metastatic, | | |
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Tooth | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 43 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Adenoma | | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 47 |
__________________________________________________________________________|____________|
Preputial Gland | | 5 |
__________________________________________________________________________|____________|
Prostate | | 47 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
__________________________________________________________________________|____________|
Testes | | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 44 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 44 |
__________________________________________________________________________|____________|
Spleen | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Thymus | | 33 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 14 |
__________________________________________________________________________|____________|
Skin | | 49 |
Mast Cell Tumor Malignant | | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05042-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/15/97
Route: GAVAGE Time: 16:14:55
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 7 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 47 |
Adenoma | | 3 |
Adenoma, Mild | | 1 |
Adenoma, Multiple | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | | 1 |
Renal Tubule, Adenoma | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
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