TR 391 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. TRIS (2-CHLOROETHYL) PHOSPHATE DATE: 09/05/94
EXPERIMENT: 05042 TEST: 02 TIME: 16:37:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128
PATHOLOGIST: J. MOE CAS: 115-96-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. TRIS (2-CHLOROETHYL) PHOSPHATE DATE: 09/05/94
EXPERIMENT: 05042 TEST: 02 TIME: 16:37:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128
PATHOLOGIST: J. MOE CAS: 115-96-8
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Microbiological Assoc. TRIS (2-CHLOROETHYL) PHOSPHATE DATE: 09/05/94
EXPERIMENT: 05042 TEST: 02 TIME: 16:37:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128
PATHOLOGIST: J. MOE CAS: 115-96-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TRIS (2-CHLOROETHYL) PHOSPHATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin: Subcutaneous Tissue Fibrosarcoma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant and Benign Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 0/23 (0%) 2/43 (5%) | 0/49 (0%) 0/12 (0%) 1/48 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 8.7% | 0.0% 0.0% 2.9% |
|TERMINAL (d) | 0/24 (0%) 0/0 2/23 (9%) | 0/31 (0%) 0/0 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 (e) P=0.228 | P=0.325 (e) P=0.518 |
|INCIDENTAL TUMOR | P=0.135 (e) P=0.228 | P=0.325 (e) P=0.518 |
|LOGISTIC REGRESSION | P=0.135 (e) P=0.228 | P=0.325 (e) P=0.518 |
|COCHRAN-ARMITAGE | P=0.107 | P=0.294 |
|FISHER EXACT | (e) P=0.231 | (e) P=0.495 |
|=================================================================================================================================|
| |
|Ear |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/25 (0%) 0/25 (0%) 0/25 (0%) | 0/31 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.112 (e) P=0.278 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.122 (e) P=0.263 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.081 (e) P=0.199 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 5/50 (10%) | 3/50 (6%) 7/50 (14%) 7/50 (14%) |
|ADJUSTED (b) | 20.6% 26.0% 18.2% | 9.7% 18.1% 19.2% |
|TERMINAL (d) | 3/25 (12%) 4/25 (16%) 4/25 (16%) | 3/31 (10%) 6/37 (16%) 6/35 (17%) |
|FIRST INCIDENCE (DAYS) | 681 638 634 | 729 (T) 658 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.441N P=0.369 P=0.493N | P=0.183 P=0.240 P=0.214 |
|INCIDENTAL TUMOR | P=0.450N P=0.372 P=0.508N | P=0.195 P=0.253 P=0.227 |
|LOGISTIC REGRESSION | P=0.448N P=0.372 P=0.508N | P=0.184 P=0.232 P=0.214 |
|COCHRAN-ARMITAGE | P=0.440N | P=0.135 |
|FISHER EXACT | P=0.387 P=0.500N | P=0.159 P=0.159 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 6/50 (12%) | 3/50 (6%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | 20.6% 26.0% 20.8% | 9.7% 20.8% 19.2% |
|TERMINAL (d) | 3/25 (12%) 4/25 (16%) 4/25 (16%) | 3/31 (10%) 7/37 (19%) 6/35 (17%) |
|FIRST INCIDENCE (DAYS) | 681 638 634 | 729 (T) 658 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550N P=0.369 P=0.603N | P=0.192 P=0.165 P=0.214 |
|INCIDENTAL TUMOR | P=0.543 P=0.372 P=0.604 | P=0.204 P=0.175 P=0.227 |
|LOGISTIC REGRESSION | P=0.550 P=0.372 P=0.614 | P=0.193 P=0.157 P=0.214 |
|COCHRAN-ARMITAGE | P=0.558 | P=0.141 |
|FISHER EXACT | P=0.387 P=0.620N | P=0.100 P=0.159 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.0% 7.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 1/25 (4%) 1/25 (4%) | 0/31 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 719 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146 P=0.500 P=0.244 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.135 P=0.500 P=0.223 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.145 P=0.500 P=0.239 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | P=0.500 P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 4.0% 0.0% 6.8% | 0.0% 2.3% 0.0% |
|TERMINAL (d) | 1/25 (4%) 0/25 (0%) 1/25 (4%) | 0/31 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 673 | --- 666 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 P=0.500N P=0.497 | P=0.713N P=0.535 (e) |
|INCIDENTAL TUMOR | P=0.348 P=0.500N P=0.482 | P=0.671N P=0.567 (e) |
|LOGISTIC REGRESSION | P=0.358 P=0.500N P=0.496 | P=0.726 P=0.488 (e) |
|COCHRAN-ARMITAGE | P=0.360 | P=0.730 |
|FISHER EXACT | P=0.500N P=0.500 | P=0.495 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.7% 12.5% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/25 (4%) 2/25 (8%) 0/25 (0%) | 0/31 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 670 623 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.325 P=0.246N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.197N P=0.360 P=0.257N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.225N P=0.334 P=0.240N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.222N | (e) |
|FISHER EXACT | P=0.339 P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 18/50 (36%) 28/50 (56%) | 3/50 (6%) 3/50 (6%) 5/50 (10%) |
|ADJUSTED (b) | 60.0% 53.5% 79.2% | 9.7% 7.4% 13.7% |
|TERMINAL (d) | 12/25 (48%) 10/25 (40%) 18/25 (72%) | 3/31 (10%) 2/37 (5%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 636 623 571 | 729 (T) 626 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.087 P=0.460N P=0.103 | P=0.340 P=0.576N P=0.426 |
|INCIDENTAL TUMOR | P=0.047 * P=0.433N P=0.056 | P=0.330 P=0.569N P=0.449 |
|LOGISTIC REGRESSION | P=0.045 * P=0.450N P=0.055 | P=0.339 P=0.592N P=0.430 |
|COCHRAN-ARMITAGE | P=0.065 | P=0.283 |
|FISHER EXACT | P=0.418N P=0.080 | P=0.661N P=0.357 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 10/50 (20%) 10/50 (20%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 26.2% 28.5% 27.8% | 6.3% 4.5% 7.2% |
|TERMINAL (d) | 2/25 (8%) 4/25 (16%) 4/25 (16%) | 1/31 (3%) 0/37 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 620 532 469 | 718 614 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.528 P=0.555 P=0.573 | P=0.468 P=0.624N P=0.561 |
|INCIDENTAL TUMOR | P=0.491N P=0.553N P=0.523N | P=0.456 P=0.563N P=0.570 |
|LOGISTIC REGRESSION | P=0.510N P=0.508N P=0.556N | P=0.397 P=0.687N P=0.521 |
|COCHRAN-ARMITAGE | P=0.550 | P=0.406 |
|FISHER EXACT | P=0.598N P=0.598N | P=0.691N P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 10/50 (20%) 11/50 (22%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 26.2% 28.5% 29.6% | 6.3% 4.5% 7.2% |
|TERMINAL (d) | 2/25 (8%) 4/25 (16%) 4/25 (16%) | 1/31 (3%) 0/37 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 620 532 469 | 718 614 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.438 P=0.555 P=0.481 | P=0.468 P=0.624N P=0.561 |
|INCIDENTAL TUMOR | P=0.521 P=0.553N P=0.601 | P=0.456 P=0.563N P=0.570 |
|LOGISTIC REGRESSION | P=0.495 P=0.508N P=0.558 | P=0.397 P=0.687N P=0.521 |
|COCHRAN-ARMITAGE | P=0.451 | P=0.406 |
|FISHER EXACT | P=0.598N P=0.500 | P=0.691N P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 27/50 (54%) 33/50 (66%) | 5/50 (10%) 5/50 (10%) 8/50 (16%) |
|ADJUSTED (b) | 67.6% 68.3% 81.7% | 15.6% 11.6% 20.2% |
|TERMINAL (d) | 13/25 (52%) 13/25 (52%) 18/25 (72%) | 4/31 (13%) 2/37 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 620 532 469 | 718 614 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.149 P=0.454 P=0.168 | P=0.300 P=0.511N P=0.367 |
|INCIDENTAL TUMOR | P=0.086 P=0.522 P=0.107 | P=0.277 P=0.463N P=0.387 |
|LOGISTIC REGRESSION | P=0.073 P=0.488 P=0.087 | P=0.257 P=0.562N P=0.351 |
|COCHRAN-ARMITAGE | P=0.094 | P=0.221 |
|FISHER EXACT | P=0.500 P=0.111 | P=0.630N P=0.277 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 27/50 (54%) 33/50 (66%) | 5/50 (10%) 5/50 (10%) 8/50 (16%) |
|ADJUSTED (b) | 67.6% 68.3% 81.7% | 15.6% 11.6% 20.2% |
|TERMINAL (d) | 13/25 (52%) 13/25 (52%) 18/25 (72%) | 4/31 (13%) 2/37 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 620 532 469 | 718 614 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.149 P=0.454 P=0.168 | P=0.300 P=0.511N P=0.367 |
|INCIDENTAL TUMOR | P=0.086 P=0.522 P=0.107 | P=0.277 P=0.463N P=0.387 |
|LOGISTIC REGRESSION | P=0.073 P=0.488 P=0.087 | P=0.257 P=0.562N P=0.351 |
|COCHRAN-ARMITAGE | P=0.094 | P=0.221 |
|FISHER EXACT | P=0.500 P=0.111 | P=0.630N P=0.277 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 11/50 (22%) 9/50 (18%) | 2/50 (4%) 2/50 (4%) 5/49 (10%) |
|ADJUSTED (b) | 28.0% 39.7% 30.0% | 5.3% 5.4% 14.3% |
|TERMINAL (d) | 7/25 (28%) 9/25 (36%) 6/25 (24%) | 0/31 (0%) 2/37 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 655 571 | 632 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345 P=0.197 P=0.393 | P=0.181 P=0.631N P=0.273 |
|INCIDENTAL TUMOR | P=0.333 P=0.197 P=0.391 | P=0.171 P=0.590N P=0.258 |
|LOGISTIC REGRESSION | P=0.336 P=0.182 P=0.381 | P=0.172 P=0.675N P=0.254 |
|COCHRAN-ARMITAGE | P=0.348 | P=0.140 |
|FISHER EXACT | P=0.218 P=0.393 | P=0.691N P=0.210 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 10.2% 2.4% 6.3% | 3.2% 0.0% 0.0% |
|TERMINAL (d) | 2/25 (8%) 0/25 (0%) 1/25 (4%) | 1/31 (3%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 636 626 604 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.417N P=0.316N P=0.516N | P=0.250N P=0.465N P=0.476N |
|INCIDENTAL TUMOR | P=0.332N P=0.271N P=0.439N | P=0.250N P=0.465N P=0.476N |
|LOGISTIC REGRESSION | P=0.402N P=0.306N P=0.504N | P=0.250N P=0.465N P=0.476N |
|COCHRAN-ARMITAGE | P=0.399N | P=0.272N |
|FISHER EXACT | P=0.309N P=0.500N | P=0.500N P=0.505N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/50 (24%) 10/50 (20%) | 3/50 (6%) 2/50 (4%) 5/49 (10%) |
|ADJUSTED (b) | 37.6% 41.1% 31.7% | 8.4% 5.4% 14.3% |
|TERMINAL (d) | 9/25 (36%) 9/25 (36%) 6/25 (24%) | 1/31 (3%) 2/37 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 636 626 571 | 632 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.542 P=0.388 P=0.594 | P=0.327 P=0.424N P=0.428 |
|INCIDENTAL TUMOR | P=0.526N P=0.410 P=0.567N | P=0.317 P=0.386N P=0.412 |
|LOGISTIC REGRESSION | P=0.537 P=0.368 P=0.589 | P=0.319 P=0.455N P=0.413 |
|COCHRAN-ARMITAGE | P=0.549N | P=0.265 |
|FISHER EXACT | P=0.405 P=0.598N | P=0.500N P=0.346 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 8.2% |
|TERMINAL (d) | 0/25 (0%) 0/25 (0%) 0/25 (0%) | 0/31 (0%) 0/37 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 698 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.043 * (e) P=0.145 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.048 * (e) P=0.167 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.042 * (e) P=0.144 |
|COCHRAN-ARMITAGE | (e) | P=0.037 * |
|FISHER EXACT | (e) (e) | (e) P=0.121 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 3.2% 0.0% 8.2% |
|TERMINAL (d) | 0/25 (0%) 0/25 (0%) 0/25 (0%) | 1/31 (3%) 0/37 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) --- 698 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.199 P=0.465N P=0.350 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.215 P=0.465N P=0.382 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.200 P=0.465N P=0.353 |
|COCHRAN-ARMITAGE | (e) | P=0.176 |
|FISHER EXACT | (e) (e) | P=0.500N P=0.309 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/22 (0%) 0/48 (0%) | 4/48 (8%) 3/14 (21%) 1/44 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 12.6% 100.0% 3.0% |
|TERMINAL (d) | 0/24 (0%) 0/0 0/25 (0%) | 3/29 (10%) 3/3 (100%) 1/33 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 544 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.125N P=0.046 * P=0.145N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.169N P=0.002 ** P=0.197N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.141N P=0.150 P=0.177N |
|COCHRAN-ARMITAGE | (e) | P=0.193N |
|FISHER EXACT | (e) (e) | P=0.184 P=0.209N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 10.0% 4.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 2/25 (8%) 1/25 (4%) | 0/31 (0%) 0/37 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 480 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.378 P=0.124 P=0.500 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.376 P=0.146 P=0.500 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.377 P=0.121 P=0.500 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.378 | (e) |
|FISHER EXACT | P=0.121 P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 4.0% 11.0% 7.6% | 0.0% 2.1% 7.6% |
|TERMINAL (d) | 1/25 (4%) 0/25 (0%) 0/25 (0%) | 0/31 (0%) 0/37 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 626 627 | --- 622 627 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252 P=0.176 P=0.300 | P=0.073 P=0.547 P=0.148 |
|INCIDENTAL TUMOR | P=0.267 P=0.177 P=0.351 | P=0.043 * P=0.557 P=0.131 |
|LOGISTIC REGRESSION | P=0.159 P=0.179 P=0.303 | P=0.057 P=0.450 P=0.128 |
|COCHRAN-ARMITAGE | P=0.252 | P=0.060 |
|FISHER EXACT | P=0.181 P=0.309 | P=0.500 P=0.121 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 4/50 (8%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 8.0% 19.9% 11.3% | 0.0% 2.1% 7.6% |
|TERMINAL (d) | 2/25 (8%) 2/25 (8%) 1/25 (4%) | 0/31 (0%) 0/37 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 480 627 | --- 622 627 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 P=0.084 P=0.333 | P=0.073 P=0.547 P=0.148 |
|INCIDENTAL TUMOR | P=0.313 P=0.095 P=0.377 | P=0.043 * P=0.557 P=0.131 |
|LOGISTIC REGRESSION | P=0.294 P=0.081 P=0.332 | P=0.057 P=0.450 P=0.128 |
|COCHRAN-ARMITAGE | P=0.297 | P=0.060 |
|FISHER EXACT | P=0.080 P=0.339 | P=0.500 P=0.121 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 8.0% 11.0% 7.6% | 0.0% 2.1% 7.6% |
|TERMINAL (d) | 2/25 (8%) 0/25 (0%) 0/25 (0%) | 0/31 (0%) 0/37 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 626 627 | --- 622 627 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411 P=0.329 P=0.491 | P=0.073 P=0.547 P=0.148 |
|INCIDENTAL TUMOR | P=0.437 P=0.335 P=0.547 | P=0.043 * P=0.557 P=0.131 |
|LOGISTIC REGRESSION | P=0.414 P=0.335 P=0.497 | P=0.057 P=0.450 P=0.128 |
|COCHRAN-ARMITAGE | P=0.417 | P=0.060 |
|FISHER EXACT | P=0.339 P=0.500 | P=0.500 P=0.121 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/28 (4%) 0/49 (0%) | 0/50 (0%) 1/20 (5%) 0/48 (0%) |
|ADJUSTED (b) | 7.9% 3.7% 0.0% | 0.0% 12.5% 0.0% |
|TERMINAL (d) | 0/25 (0%) 0/3 (0%) 0/24 (0%) | 0/31 (0%) 1/8 (13%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 632 712 --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066N P=0.331N P=0.130N | P=0.687N P=0.233 (e) |
|INCIDENTAL TUMOR | P=0.062N P=0.307N P=0.118N | P=0.687N P=0.233 (e) |
|LOGISTIC REGRESSION | P=0.081N P=0.578N P=0.124N | P=0.687N P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.078N | P=0.703 |
|FISHER EXACT | P=0.546N P=0.125N | P=0.286 (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/24 (0%) 0/50 (0%) | |
|ADJUSTED (b) | 7.3% 0.0% 0.0% | |
|TERMINAL (d) | 1/25 (4%) 0/0 0/25 (0%) | |
|FIRST INCIDENCE (DAYS) | 694 --- --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.507N P=0.232N | |
|INCIDENTAL TUMOR | P=0.131N P=0.515N P=0.257N | |
|LOGISTIC REGRESSION | P=0.129N P=0.659N P=0.239N | |
|COCHRAN-ARMITAGE | P=0.117N | |
|FISHER EXACT | P=0.454N P=0.247N | |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | | 0.0% 2.7% 7.6% |
|TERMINAL (d) | | 0/31 (0%) 1/37 (3%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) 519 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.072 P=0.535 P=0.148 |
|INCIDENTAL TUMOR | | P=0.078 P=0.535 P=0.144 |
|LOGISTIC REGRESSION | | P=0.057 P=0.535 P=0.113 |
|COCHRAN-ARMITAGE | | P=0.060 |
|FISHER EXACT | | P=0.500 P=0.121 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 17.6% 15.7% 0.0% | 0.0% 5.4% 2.9% |
|TERMINAL (d) | 2/25 (8%) 2/25 (8%) 0/25 (0%) | 0/31 (0%) 2/37 (5%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 632 623 --- | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.023N* P=0.528N P=0.022N* | P=0.390 P=0.278 P=0.524 |
|INCIDENTAL TUMOR | P=0.015N* P=0.484N P=0.019N* | P=0.390 P=0.278 P=0.524 |
|LOGISTIC REGRESSION | P=0.018N* P=0.503N P=0.018N* | P=0.390 P=0.278 P=0.524 |
|COCHRAN-ARMITAGE | P=0.017N* | P=0.360 |
|FISHER EXACT | P=0.500N P=0.013N* | P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 6/50 (12%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 17.6% 19.4% 0.0% | 0.0% 5.4% 2.9% |
|TERMINAL (d) | 2/25 (8%) 3/25 (12%) 0/25 (0%) | 0/31 (0%) 2/37 (5%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 632 623 --- | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.590 P=0.022N* | P=0.390 P=0.278 P=0.524 |
|INCIDENTAL TUMOR | P=0.019N* P=0.606N P=0.019N* | P=0.390 P=0.278 P=0.524 |
|LOGISTIC REGRESSION | P=0.022N* P=0.618 P=0.018N* | P=0.390 P=0.278 P=0.524 |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.360 |
|FISHER EXACT | P=0.620N P=0.013N* | P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.8% 0.0% 0.0% | 3.2% 0.0% 5.7% |
|TERMINAL (d) | 0/25 (0%) 0/25 (0%) 0/25 (0%) | 1/31 (3%) 0/37 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 715 --- --- | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.266N P=0.500N P=0.492N | P=0.390 P=0.465N P=0.543 |
|INCIDENTAL TUMOR | P=0.291N P=0.515N P=0.531N | P=0.390 P=0.465N P=0.543 |
|LOGISTIC REGRESSION | P=0.271N P=0.506N P=0.501N | P=0.390 P=0.465N P=0.543 |
|COCHRAN-ARMITAGE | P=0.269N | P=0.360 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 1/50 (2%) | 11/50 (22%) 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | 16.4% 9.0% 2.7% | 28.7% 16.2% 14.3% |
|TERMINAL (d) | 1/25 (4%) 1/25 (4%) 0/25 (0%) | 5/31 (16%) 2/37 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 654 532 666 | 537 654 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076N P=0.378N P=0.107N | P=0.042N* P=0.136N P=0.059N |
|INCIDENTAL TUMOR | P=0.084N P=0.352N P=0.125N | P=0.030N* P=0.086N P=0.067N |
|LOGISTIC REGRESSION | P=0.071N P=0.358N P=0.105N | P=0.031N* P=0.050N P=0.062N |
|COCHRAN-ARMITAGE | P=0.070N | P=0.063N |
|FISHER EXACT | P=0.357N P=0.102N | P=0.218N P=0.086N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 1/50 (2%) | 10/50 (20%) 7/50 (14%) 3/50 (6%) |
|ADJUSTED (b) | 13.0% 9.0% 2.7% | 26.0% 16.2% 8.6% |
|TERMINAL (d) | 1/25 (4%) 1/25 (4%) 0/25 (0%) | 4/31 (13%) 2/37 (5%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 654 532 666 | 537 654 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140N P=0.518N P=0.183N | P=0.018N* P=0.196N P=0.027N* |
|INCIDENTAL TUMOR | P=0.154N P=0.492N P=0.212N | P=0.011N* P=0.138N P=0.028N* |
|LOGISTIC REGRESSION | P=0.134N P=0.501N P=0.182N | P=0.011N* P=0.084N P=0.029N* |
|COCHRAN-ARMITAGE | P=0.133N | P=0.028N* |
|FISHER EXACT | P=0.500N P=0.181N | P=0.298N P=0.036N* |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 28/50 (56%) 32/50 (64%) | 14/50 (28%) 16/50 (32%) 19/50 (38%) |
|ADJUSTED (b) | 79.8% 79.4% 88.4% | 40.5% 39.4% 48.3% |
|TERMINAL (d) | 18/25 (72%) 18/25 (72%) 21/25 (84%) | 11/31 (35%) 13/37 (35%) 15/35 (43%) |
|FIRST INCIDENCE (DAYS) | 636 480 571 | 544 626 519 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263 P=0.533 P=0.295 | P=0.296 P=0.528N P=0.343 |
|INCIDENTAL TUMOR | P=0.187 P=0.577 P=0.213 | P=0.287 P=0.581N P=0.339 |
|LOGISTIC REGRESSION | P=0.176 P=0.531 P=0.196 | P=0.273 P=0.572N P=0.320 |
|COCHRAN-ARMITAGE | P=0.239 | P=0.169 |
|FISHER EXACT | P=0.580N P=0.270 | P=0.414 P=0.198 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 21/50 (42%) 21/50 (42%) | 14/50 (28%) 15/50 (30%) 20/50 (40%) |
|ADJUSTED (b) | 54.2% 50.2% 49.6% | 35.1% 32.1% 44.7% |
|TERMINAL (d) | 7/25 (28%) 6/25 (24%) 6/25 (24%) | 6/31 (19%) 6/37 (16%) 11/35 (31%) |
|FIRST INCIDENCE (DAYS) | 620 532 469 | 397 614 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.483N P=0.548N P=0.509N | P=0.261 P=0.457N P=0.302 |
|INCIDENTAL TUMOR | P=0.396N P=0.462N P=0.451N | P=0.173 P=0.501N P=0.203 |
|LOGISTIC REGRESSION | P=0.439N P=0.397N P=0.486N | P=0.186 P=0.591N P=0.231 |
|COCHRAN-ARMITAGE | P=0.460N | P=0.120 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.146 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05042 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TRIS (2-CHLOROETHYL) PHOSPHATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 175MG/KG 350MG/KG | CONTROL 175MG/KG 350MG/KG |
| | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 39/50 (78%) 42/50 (84%) | 25/50 (50%) 26/50 (52%) 37/50 (74%) |
|ADJUSTED (b) | 90.4% 88.4% 93.2% | 60.7% 56.2% 78.6% |
|TERMINAL (d) | 21/25 (84%) 20/25 (80%) 22/25 (88%) | 15/31 (48%) 17/37 (46%) 25/35 (71%) |
|FIRST INCIDENCE (DAYS) | 620 480 469 | 397 614 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288 P=0.442 P=0.317 | P=0.096 P=0.339N P=0.124 |
|INCIDENTAL TUMOR | P=0.153 P=0.547 P=0.175 | P=0.034 * P=0.413N P=0.042 * |
|LOGISTIC REGRESSION | P=0.155 P=0.497 P=0.150 | P=0.036 * P=0.429N P=0.047 * |
|COCHRAN-ARMITAGE | P=0.194 | P=0.010 ** |
|FISHER EXACT | P=0.500 P=0.227 | P=0.500 P=0.011 * |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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