TR 391 Mouse Pathology Tables
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | |
Periesophageal Tissue, Inflammation, | |
Acute | 2 1 |
Wall, Inflammation, Necrotizing | |
__________________________________________________________________________|
Gallbladder | + + + + + + + A + A + + + + A + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M M M M M M M A M M + M A M M + A M + M + M M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A + + + A + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Mast Cell | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Basophilic Focus | |
Acinus, Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
Infiltration Cellular, Mast Cell | |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Mucosa, Dilatation | 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Epicardium, Inflammation, Acute | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Ballooning | 2 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + M + + + + + M M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 3 3 2 |
Pars Distalis, Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 1 |
Follicular Cell, Hyperplasia | 1 1 4 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M M + + M M + + + + + M M + M + + + + + + + M + +|
Cyst | 3 3 2 3 4 2 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 3 3 2 3 2 3 2 2 2 1 2 3 3 3 1 2 3 2 2 1 3 3 3 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + + + + + + + +|
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Inguinal, Infiltration Cellular, | |
Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + M + +|
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | 1 |
Hyperplasia, Lymphoid | |
Mediastinum, Foreign Body | 3 |
Mediastinum, Inflammation, Acute | 2 3 |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 |
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Head, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Meninges, Inflammation, Chronic | |
Thalamus, Inflammation | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | 2|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|
| 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | |
Mediastinum, Foreign Body | 2 1 |
Mediastinum, Inflammation, Acute | 3 |
Pleura, Inflammation, Acute | 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Inflammation, Acute | 1 |
Respiratory Epithelium, Inflammation,| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Foreign Body | 2 |
Peritracheal Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 2 2 1 1 1 |
Glomerulus, Amyloid Deposition | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | 1 |
Periesophageal Tissue, Inflammation, | |
Acute | 2 |
Wall, Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Gallbladder | + + + + A + + + + M + + + A + + + + M A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + A + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M A M M + M A M M M A M M + M M A + M M M M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + A + + + + + A + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + A + + + A + + + + + A + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Infiltration Cellular, Mast Cell | 1 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 4 2 |
Acinus, Basophilic Focus | 3 |
Acinus, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 1 1 |
Infiltration Cellular, Mast Cell | 4 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 1 |
Mucosa, Dilatation | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Epicardium, Inflammation, Acute | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 2 |
Degeneration, Ballooning | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + + + + + M + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 1 2 |
Pars Distalis, Hyperplasia | 3 1 2 |
Pars Distalis, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M M + + + M + + + + + + + + + + M + + + M + + +|
Cyst | 2 3 2 2 4 3 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Endometrium, Hyperplasia, Cystic | 3 1 1 3 2 2 3 2 3 2 3 3 1 1 3 3 3 1 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +|
Myelofibrosis | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Infiltration Cellular, | |
Mast Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + M + + + + + + + + M +|
Ectasia | 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3|
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + + + M + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 1 |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Acute | 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Subcutaneous Tissue, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 3 |
Head, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Meninges, Inflammation, Chronic | 1 |
Thalamus, Inflammation | 1 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Foreign Body | 3 |
Hemorrhage | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|
DAY ON TEST | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|
| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | 1 |
Mediastinum, Foreign Body | 1 2 |
Mediastinum, Inflammation, Acute | 3 |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 2 |
Inflammation, Acute | |
Respiratory Epithelium, Inflammation,| |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Foreign Body | 2 |
Peritracheal Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 2 1 1 |
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Periesophageal Tissue, Foreign Body | | 1 1.0|
Periesophageal Tissue, Inflammation, | | |
Acute | | 3 1.7|
Wall, Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | | 41 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 43 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Vacuolization Cytoplasmic | | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Infiltration Cellular, Mast Cell | | 1 1.0|
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Acinus, Atrophy | | 4 2.3|
Acinus, Basophilic Focus | | 1 3.0|
Acinus, Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Inflammation, Chronic | | 8 1.3|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Squamous | | 4 1.5|
Infiltration Cellular, Mast Cell | | 1 4.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Infiltration Cellular, Mast Cell | | 1 1.0|
Mucosa, Dilatation | | 1 2.0|
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 49 |
Inflammation, Acute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Epicardium, Inflammation, Acute | | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Atrophy | | 1 2.0|
Degeneration, Ballooning | | 1 2.0|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Angiectasis | | 4 2.0|
Pars Distalis, Hyperplasia | | 6 2.3|
Pars Distalis, Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 1.5|
Follicular Cell, Hyperplasia | | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 37 |
Cyst | | 14 2.8|
__________________________________________________________________________|____________|
Uterus | | 50 |
Inflammation, Chronic | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 49 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myelofibrosis | | 12 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Iliac, Hemorrhage | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 45 |
Ectasia | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Lymphoid | | 2 1.5|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 45 |
Cyst | | 1 1.0|
Hyperplasia, Lymphoid | | 1 1.0|
Mediastinum, Foreign Body | | 1 3.0|
Mediastinum, Inflammation, Acute | | 3 2.3|
Thymocyte, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
Hyperplasia, Cystic | | 3 1.7|
__________________________________________________________________________|____________|
Skin | | 50 |
Foreign Body | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
Subcutaneous Tissue, Abscess | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 49 |
Hemorrhage | | 1 3.0|
Head, Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage | | 1 3.0|
Meninges, Inflammation, Chronic | | 1 1.0|
Thalamus, Inflammation | | 1 1.0|
Thalamus, Mineralization | | 21 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 2.5|
Foreign Body | | 1 3.0|
Hemorrhage | | 2 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinum, Foreign Body | | 4 1.5|
Mediastinum, Inflammation, Acute | | 2 3.0|
Pleura, Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
Peritracheal Tissue, Foreign Body | | 2 2.0|
Peritracheal Tissue, Inflammation, | | |
Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 8 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | | 8 1.4|
Glomerulus, Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M + M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 3 |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 2 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + +|
Acinus, Atrophy | 2 |
Acinus, Basophilic Focus | |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Inflammation, Chronic | 1 |
Atrium, Thrombosis | |
Epicardium, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + M +|
Cyst | 3 3 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 2 3 3 1 3 2 2 3 2 3 2 3 1 4 1 3 3 3 2 2 2|
Endometrium, Inflammation, Acute | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2|
Hyperplasia, Lymphoid | 3 1 |
__________________________________________________________________________|
Thymus | + M + I +|
Mediastinum, Inflammation, Acute | 3 |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2|
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Acute | 4 1 |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|
| 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Necrosis, Liquifactive | 3 |
Thalamus, Mineralization | 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Foreign Body | 1 1 |
Fat, Mediastinum, Necrosis | |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Acute | |
Pleura, Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + +|
Peritracheal Tissue, Foreign Body | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 1 |
Metaplasia, Osseous | 1 |
Mineralization | |
Nephropathy | |
Medulla, Inflammation, Acute | |
Renal Tubule, Karyomegaly | |
__________________________________________________________________________|
Urinary Bladder | + + + M +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + + A A|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M M M A A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Eosinophilic Focus | 1 1 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | |
Necrosis, Coagulative | 1 3 2|
Vacuolization Cytoplasmic | 2 2|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Basophilic Focus | 1|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
Inflammation, Chronic | 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Inflammation, Chronic | |
Atrium, Thrombosis | 2 |
Epicardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + M +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + M + +|
Cyst | 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 |
Endometrium, Hyperplasia, Cystic | 2 3 4 2 3 2 2 2 3 3 3 3 2 3 3 2 3 3 2 3 2|
Endometrium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + +|
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + + + + + M + + + + +|
Hematopoietic Cell Proliferation | 1 3 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + + M + M +|
Mediastinum, Inflammation, Acute | |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Acute | 1 |
Subcutaneous Tissue, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|
| 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Necrosis, Liquifactive | |
Thalamus, Mineralization | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 2 |
Inflammation, Chronic | 1 2 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Foreign Body | 1 |
Fat, Mediastinum, Necrosis | 2 |
Mediastinum, Foreign Body | 2 |
Mediastinum, Inflammation, Acute | 3 |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + M +|
Peritracheal Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infarct | 2 |
Metaplasia, Osseous | |
Mineralization | 2 |
Nephropathy | 1 |
Medulla, Inflammation, Acute | 2 |
Renal Tubule, Karyomegaly | 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 13 |
__________________________________________________________________________|____________|
Gallbladder | | 8 |
__________________________________________________________________________|____________|
Intestine Large | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 11 |
__________________________________________________________________________|____________|
Intestine Small | | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 12 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 3.0|
Eosinophilic Focus | | 3 1.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Necrosis, Coagulative | | 3 2.0|
Vacuolization Cytoplasmic | | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Necrosis | | 8 2.9|
__________________________________________________________________________|____________|
Pancreas | | 13 |
Acinus, Atrophy | | 2 1.5|
Acinus, Basophilic Focus | | 1 1.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 13 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 13 |
Inflammation, Chronic | | 1 1.0|
Atrium, Thrombosis | | 1 2.0|
Epicardium, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | | 14 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 12 |
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 16 |
Cyst | | 6 2.8|
__________________________________________________________________________|____________|
Uterus | | 43 |
Hydrometra | | 1 4.0|
Endometrium, Hyperplasia, Cystic | | 42 2.5|
Endometrium, Inflammation, Acute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 13 |
__________________________________________________________________________|____________|
Lymph Node | | 17 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 16 |
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | | 20 |
Hematopoietic Cell Proliferation | | 5 2.2|
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | | 8 |
Mediastinum, Inflammation, Acute | | 1 3.0|
Thymocyte, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 33 |
Hyperplasia, Cystic | | 3 2.0|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 48 |
Fibrosis | | 1 2.0|
Inflammation, Acute | | 3 2.0|
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 13 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 13 |
Necrosis, Liquifactive | | 1 3.0|
Thalamus, Mineralization | | 6 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 4 1.5|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Alveolus, Foreign Body | | 3 1.0|
Fat, Mediastinum, Necrosis | | 1 2.0|
Mediastinum, Foreign Body | | 1 2.0|
Mediastinum, Inflammation, Acute | | 1 3.0|
Pleura, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 14 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 12 |
Peritracheal Tissue, Foreign Body | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Hyperplasia | | 4 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Infarct | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
175MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 2.0|
Nephropathy | | 1 1.0|
Medulla, Inflammation, Acute | | 1 2.0|
Renal Tubule, Karyomegaly | | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M A + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + M M A + M M M A M + M M M M M M M M A M M M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | 1 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | |
Inflammation, Subacute | 2 |
Necrosis, Coagulative | 2 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + I + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Acinus, Atrophy | 4 1 1 1 |
Acinus, Basophilic Focus | 1 |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 1 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Dilatation | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Myocardium, Necrosis, Zenkers | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Ballooning | 3 |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + M + + M + M M + + + + M + + + + M M M +|
Cyst | 2 3 3 2 |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 4 2 2 1 1 2 3 1 3 3 2 3 2 1 3 2 2 2 4 2 3 2 2 2|
Endometrium, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 1 |
Myelofibrosis | 1 1 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + M + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 4 |
__________________________________________________________________________|
Spleen | M + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 3 1 2 |
__________________________________________________________________________|
Thymus | + + + M + + M + + + M + + + + + + + + + + + M + +|
Cyst | 1 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + M + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 |
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Face, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Head, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | |
Thalamus, Mineralization | 1 1 1 1 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
Leukocytosis | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Arteriole, Hyperplasia | |
Mediastinum, Foreign Body | 3 2 |
Mediastinum, Inflammation, Acute | 3 |
Mediastinum, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Foreign Body | 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|
| 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Metaplasia, Osseous | |
Nephropathy | 1 1 2 |
Cortex, Necrosis, Coagulative | |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M A A M M M M M M M M + M M M M M M + + M A M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 2|
Inflammation, Chronic | 2 |
Inflammation, Subacute | 1 |
Necrosis, Coagulative | 2 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 3 3 1 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 2 |
Acinus, Basophilic Focus | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + M + + + + + + + + + + + + + + +|
Mucosa, Dilatation | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3|
Myocardium, Necrosis, Zenkers | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Ballooning | |
Hematopoietic Cell Proliferation | 3|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + M + M + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + M + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 1 2 2 |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + M + + + + + M M + + + + + + + + + + + M + M|
Cyst | 2 1 3 |
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 3 2 1 2 3 4 3 3 2 3 3 3 3 2 3 3 3 4 3 3 3 2 2|
Endometrium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
Myelofibrosis | 1 1 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3|
Hyperplasia, Lymphoid | 4 3 2 |
__________________________________________________________________________|
Thymus | + M + M + + M + + + + + M + M + + + M + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + M + + + M + + + + +|
Hyperplasia, Cystic | 1 2 |
Duct, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Face, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Head, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | 1 |
Thalamus, Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 3 3 |
Leukocytosis | 4 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 1 |
Arteriole, Hyperplasia | 2 |
Mediastinum, Foreign Body | 1 |
Mediastinum, Inflammation, Acute | 3 |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|
| 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
350MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 4 |
Metaplasia, Osseous | 2 |
Nephropathy | 1 1 3 3 1 2 |
Cortex, Necrosis, Coagulative | 2 |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 2 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 43 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Clear Cell Focus | | 1 1.0|
Eosinophilic Focus | | 1 1.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | | 2 1.5|
Necrosis, Coagulative | | 4 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Necrosis | | 8 2.5|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | | 6 1.7|
Acinus, Basophilic Focus | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
Inflammation, Chronic | | 5 1.2|
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Hyperplasia, Squamous | | 8 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
Mucosa, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 49 |
Inflammation, Subacute | | 1 3.0|
Myocardium, Necrosis, Zenkers | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Ballooning | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | | 44 |
Pars Distalis, Angiectasis | | 4 1.8|
Pars Distalis, Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicular Cell, Hyperplasia | | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 35 |
Cyst | | 7 2.3|
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Endometrium, Hyperplasia, Cystic | | 48 2.5|
Endometrium, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia, Reticulum Cell | | 1 1.0|
Myelofibrosis | | 14 1.4|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 5 2.8|
Hyperplasia, Lymphoid | | 6 2.5|
__________________________________________________________________________|____________|
Thymus | | 40 |
Cyst | | 3 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 45 |
Hyperplasia, Cystic | | 5 1.6|
Duct, Ectasia | | 1 2.0|
Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic | | 2 1.0|
Face, Inflammation, Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Inflammation, Chronic | | 1 2.0|
Head, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Meninges, Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | | 23 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 3.0|
Leukocytosis | | 1 4.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Arteriole, Hyperplasia | | 1 2.0|
Mediastinum, Foreign Body | | 3 2.0|
Mediastinum, Inflammation, Acute | | 2 3.0|
Mediastinum, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
350MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
Glands, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Infarct | | 2 1.5|
Inflammation, Chronic | | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | | 9 1.7|
Cortex, Necrosis, Coagulative | | 1 2.0|
Renal Tubule, Karyomegaly | | 44 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Perforation | 3 |
Periesophageal Tissue, Foreign Body | |
Periesophageal Tissue, Inflammation, | |
Acute | 3 2|
Periesophageal Tissue, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + A M + + A + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M + M M + A M M M M M + M M + + M A M M + + M A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + M + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 1 |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Subacute | |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Acute | 2 |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Acinus, Atrophy | 2 1 1 1 |
Acinus, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 |
Mucosa, Dilatation | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 3 3 3 1 3 3 3 3 1 |
Inflammation, Acute | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Subacute | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + M + + +|
Atrophy | |
Degeneration, Ballooning | 1 1 1 |
Hyperplasia, Focal | |
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + M + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Acute | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M M + + + M + M + + M + + M + + M M + + + + + + M|
Cyst | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M + M M M M + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Edema | 3 |
Fibrosis | 3 |
Inflammation, Acute | 2 4 |
Inflammation, Chronic | |
Inflammation | 2 |
Pigmentation | |
Face, Foreign Body | 2 |
Face, Inflammation, Acute | 2 |
Subcutaneous Tissue, Abscess | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | |
Thalamus, Mineralization | 2 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 |
Edema | |
Foreign Body | 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Foreign Body | 1 1 |
Alveolus, Infiltration Cellular | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|
| 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Foreign Body | 1 3|
Mediastinum, Inflammation, Acute | 2 1 |
Pleura, Foreign Body | 2 |
Pleura, Inflammation, Acute | 2 3 1 |
Pleura, Inflammation, Granulomatous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + + + + + +|
Peritracheal Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Acute | |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 |
Glomerulus, Dilatation | 1 |
Pelvis, Inflammation, Acute | 2 3 |
Renal Tubule, Karyomegaly | |
Renal Tubule, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Perforation | |
Periesophageal Tissue, Foreign Body | 2 |
Periesophageal Tissue, Inflammation, | |
Acute | 2 |
Periesophageal Tissue, Inflammation, | |
Granulomatous | 2 |
__________________________________________________________________________|
Gallbladder | M + + + + + + A A A + + + + + + M + + + + M + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + M M M + M + M A M + + + M M M M M M + M M + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | 1 2 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Subacute | 1 |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | |
Fat, Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Acute | |
Acinus, Atrophy | 4 2 1 1 2 1 |
Acinus, Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mucosa, Dilatation | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 3 3 2 2 3 3 2 2 1 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
Inflammation, Subacute | 1 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration, Ballooning | 1 |
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + M + + + M + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + M + + M + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Follicular Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Inflammation, Chronic | 2 3 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 1 |
__________________________________________________________________________|
Thymus | M M M M M M + + M M + + + M + + + + M + M + + M +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + M + M M M M M + M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | |
Fibrosis | |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation | |
Pigmentation | 3 |
Face, Foreign Body | |
Face, Inflammation, Acute | |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | 1 |
Thalamus, Mineralization | 1 1 1 1 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Edema | 2 |
Foreign Body | 2 |
Inflammation, Chronic | 2 2 2 |
Alveolar Epithelium, Hyperplasia | 3 1 1 2 |
Alveolus, Foreign Body | 1 |
Alveolus, Infiltration Cellular | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|
| 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Foreign Body | 2 3 2 |
Mediastinum, Inflammation, Acute | 3 3 2 |
Pleura, Foreign Body | |
Pleura, Inflammation, Acute | |
Pleura, Inflammation, Granulomatous | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Acute | 2 |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Metaplasia, Osseous | 1 2 |
Nephropathy | 3 2 1 3 1 1 1 |
Glomerulus, Dilatation | |
Pelvis, Inflammation, Acute | 3|
Renal Tubule, Karyomegaly | 1 1 |
Renal Tubule, Necrosis, Coagulative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
Perforation | | 1 3.0|
Periesophageal Tissue, Foreign Body | | 1 2.0|
Periesophageal Tissue, Inflammation, | | |
Acute | | 3 2.3|
Periesophageal Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | | 38 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 1 3.0|
Clear Cell Focus | | 4 1.3|
Hematopoietic Cell Proliferation | | 2 3.0|
Inflammation, Subacute | | 1 1.0|
Necrosis, Coagulative | | 2 2.5|
Vacuolization Cytoplasmic | | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Inflammation, Acute | | 1 2.0|
Fat, Necrosis | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Inflammation, Acute | | 1 2.0|
Acinus, Atrophy | | 10 1.6|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Inflammation, Chronic | | 8 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute | | 2 1.5|
Mucosa, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia | | 21 2.2|
Inflammation, Acute | | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Subacute | | 1 1.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Atrophy | | 1 2.0|
Degeneration, Ballooning | | 4 1.0|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Inflammation, Acute | | 1 1.0|
Follicular Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
Inflammation, Chronic | | 6 3.5|
__________________________________________________________________________|____________|
Prostate | | 49 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Inflammation, Acute | | 1 2.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 3 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | | 29 |
Cyst | | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 9 |
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 1 1.0|
Edema | | 1 3.0|
Fibrosis | | 1 3.0|
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation | | 1 2.0|
Pigmentation | | 1 3.0|
Face, Foreign Body | | 1 2.0|
Face, Inflammation, Acute | | 1 2.0|
Subcutaneous Tissue, Abscess | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fracture Healed | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Fibrosis | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Meninges, Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | | 17 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 3 2.0|
Edema | | 1 2.0|
Foreign Body | | 2 1.5|
Inflammation, Chronic | | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.8|
Alveolus, Foreign Body | | 3 1.0|
Alveolus, Infiltration Cellular | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Mediastinum, Foreign Body | | 5 2.2|
Mediastinum, Inflammation, Acute | | 5 2.2|
Pleura, Foreign Body | | 1 2.0|
Pleura, Inflammation, Acute | | 3 2.0|
Pleura, Inflammation, Granulomatous | | 2 2.5|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
Peritracheal Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Middle Ear, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 6 |
__________________________________________________________________________|____________|
Harderian Gland | | 48 |
Hyperplasia | | 3 1.7|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Infarct | | 1 1.0|
Metaplasia, Osseous | | 2 1.5|
Nephropathy | | 9 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 2| 7| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Glomerulus, Dilatation | | 1 1.0|
Pelvis, Inflammation, Acute | | 3 2.7|
Renal Tubule, Karyomegaly | | 2 1.0|
Renal Tubule, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | 2 2|
Periesophageal Tissue, Inflammation, | |
Acute | 3 |
Periesophageal Tissue, Inflammation, | |
Chronic | |
Periesophageal Tissue, Inflammation, | |
Granulomatous | 2|
__________________________________________________________________________|
Gallbladder | + M + + M M M + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A M M M A M A M M M M A|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Basophilic Focus | 2 |
Clear Cell Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1|
Hyperplasia, Chronic, Lymphoid | |
Mixed Cell Focus | 3 3 |
Necrosis, Coagulative | 1 3 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hyperplasia, Squamous | 2 1 |
Infiltration Cellular, Mast Cell | 2 |
Inflammation, Acute | 1 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + +|
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Mineralization | 1 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + +|
Hyperplasia, Focal | |
Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + M + M +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + +|
Concretion | |
__________________________________________________________________________|
Testes | + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mediastinal, Inflammation, Acute | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + M + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 3 3|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M M M + M + + M + + +|
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 |
Subcutaneous Tissue, Abscess | 3 4|
Subcutaneous Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
Tibia, Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Acute | |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
Foreign Body | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|
| 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + +|
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Infarct | 1 |
Metaplasia, Osseous | 1 2 1 |
Nephropathy | 1 1 1 2 1 1 |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | 1 |
Periesophageal Tissue, Inflammation, | |
Acute | 2 3 |
Periesophageal Tissue, Inflammation, | |
Chronic | 3 3 |
Periesophageal Tissue, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Gallbladder | + M + M A M M + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + M M M M + + + M + M|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 2 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Chronic, Lymphoid | 4 |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Squamous | 3 |
Infiltration Cellular, Mast Cell | |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
Dysplasia | 3 2 3 1 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + +|
Hyperplasia, Focal | 1 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M + M M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + M M + + + + + + + + +|
Ultimobranchial Cyst | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
Concretion | 3 |
__________________________________________________________________________|
Testes | + + + + M + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Amyloid Deposition | 1 |
Hematopoietic Cell Proliferation | 3 2|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | M M + + + + M + + + + + + +|
Thymocyte, Necrosis | 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + + M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M +|
Acanthosis | |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Foreign Body | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Tibia, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 3 |
Mediastinum, Foreign Body | 2 2 |
Mediastinum, Inflammation, Acute | 3 3 |
Pleura, Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|
| 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
175MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Infarct | 2 |
Metaplasia, Osseous | 1 1|
Nephropathy | 3 |
Renal Tubule, Karyomegaly | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 23 |
Periesophageal Tissue, Foreign Body | | 3 1.7|
Periesophageal Tissue, Inflammation, | | |
Acute | | 3 2.7|
Periesophageal Tissue, Inflammation, | | |
Chronic | | 2 3.0|
Periesophageal Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | | 14 |
__________________________________________________________________________|____________|
Intestine Large | | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 25 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 26 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 26 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 7 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 23 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 23 |
__________________________________________________________________________|____________|
Liver | | 50 |
Amyloid Deposition | | 1 4.0|
Basophilic Focus | | 2 2.0|
Clear Cell Focus | | 1 2.0|
Eosinophilic Focus | | 3 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Chronic, Lymphoid | | 1 4.0|
Mixed Cell Focus | | 2 3.0|
Necrosis, Coagulative | | 4 2.3|
Vacuolization Cytoplasmic | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 26 |
Acinus, Atrophy | | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | | 24 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 3 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
Mucosa, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 25 |
Dysplasia | | 6 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 25 |
Mineralization | | 1 1.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 23 |
Hyperplasia, Focal | | 1 1.0|
Spindle Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 23 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
__________________________________________________________________________|____________|
Thyroid Gland | | 23 |
Ultimobranchial Cyst | | 1 3.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 24 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
__________________________________________________________________________|____________|
Prostate | | 23 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 26 |
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 24 |
Seminiferous Tubule, Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 25 |
__________________________________________________________________________|____________|
Lymph Node | | 27 |
Mediastinal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 22 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 24 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 28 |
Amyloid Deposition | | 1 1.0|
Hematopoietic Cell Proliferation | | 4 2.8|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | | 17 |
Thymocyte, Necrosis | | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 6 |
__________________________________________________________________________|____________|
Skin | | 35 |
Acanthosis | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Abscess | | 2 3.5|
Subcutaneous Tissue, Foreign Body | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 25 |
Tibia, Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 25 |
Thalamus, Mineralization | | 14 1.1|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
175MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 5 2.4|
Mediastinum, Foreign Body | | 2 2.0|
Mediastinum, Inflammation, Acute | | 2 3.0|
Pleura, Inflammation, Acute | | 2 1.0|
__________________________________________________________________________|____________|
Nose | | 25 |
Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 24 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 5 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 49 |
Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Amyloid Deposition | | 1 3.0|
Infarct | | 2 1.5|
Metaplasia, Osseous | | 5 1.2|
Nephropathy | | 7 1.4|
Renal Tubule, Karyomegaly | | 16 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | |
Periesophageal Tissue, Inflammation, | |
Acute | |
__________________________________________________________________________|
Gallbladder | M + + M M + M + M M + M + + + + + + M A + + + M A|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + M + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | M + M A A M M + M M M M M M M M M M + A M M M M A|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + + + + + + + + + + + + A + + + + A|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | |
Clear Cell Focus | 3 1 1 3 |
Cytomegaly | 3 |
Eosinophilic Focus | 2 2 3 3 |
Mitotic Alteration | 2 |
Mixed Cell Focus | 3 |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Acinus, Atrophy | 1 1 1 |
Acinus, Basophilic Focus | |
Acinus, Hyperplasia | |
Acinus, Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Squamous | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Acute | 1 |
Mucosa, Dilatation | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 3 1 3 3 2 3 3 1 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
Atrium, Thrombosis | 2 3 |
Myocardium, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + M +|
Atrophy | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + M +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + M M M M M M + + M + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + M + + + M + + + + + + + + M M|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Atrophy | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + M M + + + + + M + + M M + M + + + + M + M M|
Cyst | 1 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M + M M M M M M + M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperplasia, Basal Cell | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 3 4 |
Inflammation | 2 |
Face, Inflammation, Acute | |
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Head, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 1 |
Hemorrhage | |
Inflammation, Chronic | 1 1 |
Leukocytosis | 4|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinum, Foreign Body | 3 |
Mediastinum, Inflammation, Acute | 3 |
Pleura, Inflammation, Granulomatous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|
DAY ON TEST | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|
| 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Hyperplasia | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Metaplasia, Osseous | 1 2 |
Nephropathy | 2 1 2 4 1 3 2 |
Glomerulus, Dilatation | 1 |
Pelvis, Inflammation, Acute | 4|
Proximal Convoluted Renal Tubule, | |
Dilatation | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Karyomegaly | 1 1 1 2 1 1 2 1 1 1 1 1 2 1 3 1 1 1 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | 2 |
Periesophageal Tissue, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Gallbladder | M M + + A + + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + A + + + + + + + + + +|
Inflammation, Acute | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M + A M M M M M + + + M A M + M M + M M + + M|
Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + M + + + + + M A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + A + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Cytomegaly | |
Eosinophilic Focus | 3 1 3 4 |
Mitotic Alteration | |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 3|
Vacuolization Cytoplasmic | 3 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 1 2 2 |
Acinus, Basophilic Focus | 2 |
Acinus, Hyperplasia | 3 |
Acinus, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Mucosa, Dilatation | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + M + + + + + + + + + + + + + + + +|
Dysplasia | 3 2 3 3 1 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
Atrium, Thrombosis | |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 |
Hypertrophy, Focal | 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + M + M M + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M M + M + M + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
Follicular Cell, Hyperplasia | 1 1 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + M + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + M M + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3 |
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + M + M M M + + + + M M + + + + + M + M + + +|
Cyst | 1 |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M + + + M + M M + M M + M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Acanthosis | |
Hyperplasia, Basal Cell | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 3 |
Inflammation | |
Face, Inflammation, Acute | 2 |
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Head, Inflammation, Acute | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 1 2 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 2 1 |
Hemorrhage | 2 |
Inflammation, Chronic | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Mediastinum, Foreign Body | 1 1 |
Mediastinum, Inflammation, Acute | 3 2 2 2 |
Pleura, Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|
| 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
350MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Hyperplasia | 3 |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia, Osseous | 1 |
Nephropathy | 1 3 2 1 1 2 |
Glomerulus, Dilatation | |
Pelvis, Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Dilatation | 2 2 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Karyomegaly | 1 1 1 2 1 1 1 1 1 2 1 2 3 1 1 1 1 1 1 1 |
Renal Tubule, Pigmentation | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Periesophageal Tissue, Foreign Body | | 1 2.0|
Periesophageal Tissue, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | | 34 |
__________________________________________________________________________|____________|
Intestine Large | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 45 |
__________________________________________________________________________|____________|
Intestine Small | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 11 |
Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 41 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 44 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 5 2.0|
Cytomegaly | | 1 3.0|
Eosinophilic Focus | | 8 2.6|
Mitotic Alteration | | 1 2.0|
Mixed Cell Focus | | 1 3.0|
Necrosis, Coagulative | | 4 2.3|
Vacuolization Cytoplasmic | | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Hemorrhage | | 1 2.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Acinus, Atrophy | | 8 1.5|
Acinus, Basophilic Focus | | 1 2.0|
Acinus, Hyperplasia | | 1 3.0|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Inflammation, Chronic | | 13 1.2|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Squamous | | 6 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 47 |
Inflammation, Acute | | 2 1.0|
Mucosa, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 49 |
Dysplasia | | 18 2.4|
Inflammation, Acute | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Subacute | | 2 1.0|
Atrium, Thrombosis | | 2 2.5|
Myocardium, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Atrophy | | 4 1.3|
Hypertrophy, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 43 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Ultimobranchial Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 47 |
__________________________________________________________________________|____________|
Preputial Gland | | 5 |
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | | 47 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
__________________________________________________________________________|____________|
Testes | | 50 |
Seminiferous Tubule, Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 44 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 44 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Angiectasis | | 1 3.0|
Atrophy | | 3 2.3|
Hematopoietic Cell Proliferation | | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 33 |
Cyst | | 2 1.0|
Thymocyte, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 14 |
__________________________________________________________________________|____________|
Skin | | 49 |
Acanthosis | | 1 2.0|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic | | 4 3.3|
Inflammation | | 1 2.0|
Face, Inflammation, Acute | | 1 2.0|
Subcutaneous Tissue, Abscess | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 50 |
Inflammation, Chronic | | 1 1.0|
Head, Inflammation, Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Thalamus, Mineralization | | 26 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 2.0|
Foreign Body | | 3 1.3|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 3 1.3|
Leukocytosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.7|
Mediastinum, Foreign Body | | 3 1.7|
Mediastinum, Inflammation, Acute | | 5 2.4|
Pleura, Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Inflammation, Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 7 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 47 |
Hyperplasia | | 5 1.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Chronic | | 1 2.0|
Metaplasia, Osseous | | 3 1.3|
Nephropathy | | 13 1.9|
Glomerulus, Dilatation | | 1 1.0|
Pelvis, Inflammation, Acute | | 1 4.0|
Proximal Convoluted Renal Tubule, | | |
Dilatation | | 2 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Karyomegaly | | 39 1.3|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05042-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 16:56:49
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 1| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 2| 5| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
350MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
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