TR 391 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05042 TRIS (2-CHLOROETHYL) PHOSPHATE TIME: 16:38:01
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60128
CONT: N01CP9565001 CAS: 115-96-8
PATHOLOGIST: J. MOE
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05042 TRIS (2-CHLOROETHYL) PHOSPHATE TIME: 16:38:01
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60128
CONT: N01CP9565001 CAS: 115-96-8
PATHOLOGIST: J. MOE
TRIS (2-CHLOROETHYL) PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 11 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 23 250 298 298 442 451 485 620 626 632 |
| 636 638 656 665 670 674 675 681 688 690 |
| 694 697 714 715 |
| CENSORED DEATHS |
| 297 458 458 458 458 458 458 458 458 654 |
| 675 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175MG/KGLOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 14 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 297 480 532 620 623 626 626 638 649 653 |
| 655 663 663 664 669 673 679 688 694 712 |
| 718 |
| CENSORED DEATHS |
| 3 289 389 458 458 458 458 458 458 458 |
| 458 458 458 572 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 350MG/KGHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 14 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 60 122 134 469 511 571 588 599 604 627 |
| 634 635 666 666 666 673 698 699 706 717 |
| 719 |
| CENSORED DEATHS |
| 115 117 293 458 458 458 458 458 458 458 |
| 458 673 683 712 |
| |
==================================================================================
TRIS (2-CHLOROETHYL) PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.3 98.3 96.7 93.3 93.3 87.9 87.9 87.9 73.8 52.9 |
| | |
| | |
|175MG/KGLOW| 100.0 100.0 100.0 98.3 98.3 96.1 94.0 94.0 70.0 54.7 |
| | |
| | |
|350MG/KGHIG| 98.3 94.9 94.9 94.9 94.9 92.8 90.8 82.5 76.3 56.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 175MG/KGLOW 350MG/KGHIGH |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.9% 54.7% 56.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.745N P=0.883N P=0.792N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 567.4 629.6 560.2 |
|NATURAL DEATHS (C) | (37.3) (20.5) (43.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 618.9 621.3 604.1 |
|(STANDARD ERROR) | (20.2) (19.0) (23.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIS (2-CHLOROETHYL) PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 16 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 298 365 397 469 537 544 610 632 639 669 |
| 700 716 718 |
| CENSORED DEATHS |
| 236 302 302 304 360 458 458 458 458 458 |
| 458 458 458 458 540 669 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175MG/KGLOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 12 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 622 626 642 654 658 666 666 669 670 690 |
| 694 |
| CENSORED DEATHS |
| 324 459 459 459 459 459 459 459 459 459 |
| 459 614 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 350MG/KG HIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 12 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 72 482 489 519 537 583 627 664 670 676 |
| 696 698 706 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| 676 719 |
| |
==================================================================================
TRIS (2-CHLOROETHYL) PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 96.5 94.7 92.5 88.0 88.0 81.2 72.0 |
| | |
| | |
|175MG/KGLOW| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 89.6 77.1 |
| | |
| | |
|350MG/KG | 98.3 98.3 98.3 98.3 98.3 96.3 90.3 88.3 84.3 74.1 |
|HIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 175MG/KGLOW 350MG/KG |
| HIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 77.1% 74.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.826N P=0.551N P=0.915N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 561.1 659.7 570.7 |
|NATURAL DEATHS (C) | (39.0) ( 6.9) (47.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 612.1 662.6 648.7 |
|(STANDARD ERROR) | (19.9) (14.1) (17.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIS (2-CHLOROETHYL) PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
175MG/KGLOW = 2
350MG/KGHIGH = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 3 3 1 2 2
|
| 3 3 1 1 2 2
95 + 3 3
| 1 1 2 2
| 3 3
| 1 1 3 3
90 + 1 1 22
| 3 3
| 1 1
| 3 3 11
P 85 + 33 2 2
E | 11
R | 3 3 22
C | 22
E 80 + 311
N |
T | 1 1
| 3 1 13
S 75 +
U | 11
R |
V | 11
I 70 + 223
V |
A | 211 3
L |
65 + 11
| 2 233
|
| 113 3
60 +
| 2 2
| 1 13 3
| 22
55 + 11 2
|
| 1 1
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
TRIS (2-CHLOROETHYL) PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
175MG/KGLOW = 2
350MG/KG HIGH = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
| 3 1 1 3
| 22
| 1 1 33 2 2
P 95 + 1 1
E | 3 3 2 2
R | 1 3 1
C |
E 90 + 11 3 2 2
N | 3 3
T | 1 1
| 1 31 3
S 85 +
U | 11 33
R | 33
V | 1 1 2
I 80 + 3 3
V | 1 21
A | 2 2
L | 13 1
75 +
| 3 3
| 1 1
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
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