TR 391 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIS 2-CHLOROETHYL PHOSPHATE
NTP Experiment-Test: 05042-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 14:55:41
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 9
Early Deaths
Dead 9 4 7
Moribund 8 10 22
Accident 1 1
Gavage Death 3 4
Survivors
Terminal Sacrifice 32 33 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (49) (50)
Angiectasis 3 (6%) 1 (2%)
Basophilic Focus 16 (32%) 19 (39%) 9 (18%)
Congestion 1 (2%)
Cyst 1 (2%)
Fatty Change, Diffuse 2 (4%) 4 (8%) 3 (6%)
Fatty Change, Focal 1 (2%) 1 (2%) 2 (4%)
Fatty Change, Multifocal 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 5 (10%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (6%) 6 (12%)
Hepatodiaphragmatic Nodule, Multiple 2 (4%)
Inflammation, Focal, Necrotizing 1 (2%)
Inflammation, Granulomatous, Multifocal 10 (20%) 14 (29%) 6 (12%)
Necrosis, Multifocal 1 (2%) 2 (4%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Regeneration 1 (2%)
Bile Duct, Hyperplasia 24 (48%) 26 (53%) 28 (56%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Fatty Change 2 (4%)
Centrilobular, Necrosis 3 (6%) 1 (2%) 1 (2%)
Periportal, Fatty Change 1 (2%)
Mesentery (4) (4) (1)
Fat, Necrosis, Focal 4 (100%) 4 (100%)
Pancreas (49) (49) (50)
Acinus, Atrophy 6 (12%) 11 (22%) 7 (14%)
Stomach, Forestomach (50) (50) (49)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%)
Ulcer 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (50) (50) (50)
Degeneration, Cystic 34 (68%) 36 (72%) 36 (72%)
Erosion 1 (2%) 1 (2%)
Erosion, Multifocal 1 (2%) 1 (2%)
Ulcer 1 (2%)
Submucosa, Fibrosis 1 (2%)
Tooth (1)
Pulp, Inflammation, Necrotizing 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 11 (22%) 8 (16%) 15 (30%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Endocardium, Thrombosis 1 (2%)
Epicardium, Inflammation, Chronic Active 1 (2%)
Myocardium, Inflammation, Multifocal,
Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 4 (8%) 2 (4%) 4 (8%)
Hyperplasia, Multifocal 1 (2%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Diffuse 2 (4%)
Vacuolization Cytoplasmic, Focal 6 (13%) 5 (10%) 5 (10%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 1 (2%)
Adrenal Gland, Medulla (43) (41) (45)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (5%)
Hyperplasia, Multifocal 2 (5%) 2 (4%)
Bilateral, Hyperplasia, Focal 1 (2%)
Pituitary Gland (49) (49) (47)
Angiectasis 4 (8%) 10 (20%) 10 (21%)
Cyst 11 (22%) 14 (29%) 8 (17%)
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 5 (10%) 2 (4%)
Thyroid Gland (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 8 (16%) 6 (12%) 5 (10%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (34) (35) (32)
Hyperplasia 1 (3%) 3 (9%)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic Active 3 (9%) 2 (6%)
Duct, Ectasia 1 (3%) 4 (11%) 7 (22%)
Ovary (49) (50) (50)
Cyst 2 (4%) 1 (2%)
Uterus (50) (50) (50)
Decidual Reaction 1 (2%)
Hydrometra 1 (2%) 1 (2%)
Inflammation, Suppurative 2 (4%)
Cervix, Cyst 1 (2%)
Endometrium, Cyst 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 1 (2%)
Lymph Node (50) (49) (49)
Bronchial, Hemorrhage 1 (2%)
Bronchial, Hyperplasia, Plasma Cell 1 (2%)
Bronchial, Hyperplasia, Re Cell 1 (2%)
Mediastinal, Hemorrhage 2 (4%) 5 (10%) 4 (8%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (47) (45) (47)
Hemorrhage 1 (2%) 3 (7%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 2 (4%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mesenteric (48) (45) (49)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Sinus, Ectasia 2 (4%)
Spleen (50) (49) (50)
Hematopoietic Cell Proliferation 8 (16%) 2 (4%) 6 (12%)
Hemorrhage 1 (2%)
Necrosis 1 (2%) 2 (4%)
Capsule, Fibrosis, Focal 1 (2%)
Thymus (37) (42) (39)
Cyst 2 (5%)
Hemorrhage 1 (3%) 3 (7%) 5 (13%)
Epithelial Cell, Hyperplasia 22 (59%) 29 (69%) 20 (51%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (46) (47)
Galactocele 2 (4%) 3 (7%) 2 (4%)
Hemorrhage 1 (2%)
Duct, Ectasia 6 (13%) 5 (11%) 2 (4%)
Skin (50) (49) (49)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Ulcer, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (1) (2)
Osteopetrosis 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Brain Stem, Compression 5 (10%) 7 (14%) 1 (2%)
Brain Stem, Gliosis 1 (2%) 15 (30%)
Brain Stem, Hemorrhage 1 (2%) 12 (24%)
Brain Stem, Mineralization 7 (14%)
Brain Stem, Necrosis 1 (2%)
Brain Stem, Pigmentation, Hemosiderin 1 (2%) 17 (34%)
Cerebellum, Gliosis 1 (2%)
Cerebellum, Hemorrhage 1 (2%) 2 (4%)
Cerebellum, Necrosis 1 (2%)
Cerebellum, Pigmentation, Hemosiderin 1 (2%)
Cerebrum, Gliosis 19 (38%)
Cerebrum, Hemorrhage 1 (2%) 17 (34%)
Cerebrum, Mineralization 15 (30%)
Cerebrum, Pigmentation, Hemosiderin 22 (44%)
Meninges, Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Pons, Hemorrhage 1 (2%)
Pons, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 6 (12%) 1 (2%)
Edema 1 (2%)
Hemorrhage 3 (6%) 7 (14%)
Infiltration Cellular, Histiocyte 33 (66%) 26 (52%) 28 (56%)
Inflammation, Granulomatous, Multifocal 1 (2%) 3 (6%)
Leukocytosis 1 (2%)
Pigmentation 33 (66%) 26 (52%) 28 (56%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 8 (16%) 2 (4%)
Alveolar Epithelium, Hyperplasia, Multifocal 2 (4%) 1 (2%) 1 (2%)
Interstitium, Inflammation 1 (2%) 1 (2%) 1 (2%)
Peribronchiolar, Foreign Body 1 (2%) 2 (4%)
Pleura, Inflammation, Chronic Active 1 (2%)
Nose (50) (50) (50)
Foreign Body 2 (4%)
Fungus 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Suppurative 3 (6%) 2 (4%) 3 (6%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (2) (8)
Cataract 2 (33%) 2 (100%) 4 (50%)
Necrosis 1 (13%)
Bilateral, Cataract 2 (33%)
Retina, Degeneration 3 (50%) 2 (100%) 5 (63%)
Sclera, Metaplasia, Osseous 1 (17%)
Harderian Gland (1) (1)
Infiltration Cellular, Lymphocyte 1 (100%)
Pigmentation, Porphyrin 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Calculus Micro Observation Only 2 (4%) 5 (10%)
Cyst 1 (2%)
Nephropathy 27 (54%) 23 (46%) 32 (64%)
Pigmentation 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Pelvis, Inflammation, Chronic 1 (2%)
Renal Tubule, Epithelium, Hyperplasia 4 (8%)
Renal Tubule, Epithelium, Hyperplasia, Focal 3 (6%) 11 (22%)
Renal Tubule, Epithelium, Hyperplasia,
Multifocal 1 (2%)
Urinary Bladder (49) (49) (48)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 2 (4%)
Transitional Epithelium, Hyperplasia,
Papillary 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 9 10 10
Early Deaths
Dead 6 9 10
Moribund 5 7 14
Gavage Death 4 1
Accident 1
Survivors
Terminal Sacrifice 36 33 25
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (48) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Wall, Foreign Body 1 (2%)
Intestine Large, Cecum (50) (47) (48)
Hemorrhage 1 (2%)
Ulcer, Multifocal 1 (2%)
Intestine Large, Colon (50) (47) (49)
Inflammation, Subacute 1 (2%)
Intestine Small, Duodenum (48) (46) (47)
Erosion 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Liver (50) (50) (50)
Angiectasis 3 (6%) 1 (2%) 1 (2%)
Basophilic Focus 13 (26%) 6 (12%) 2 (4%)
Congestion 2 (4%) 1 (2%) 1 (2%)
Degeneration, Cystic 2 (4%) 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 2 (4%) 1 (2%) 4 (8%)
Fatty Change, Focal 2 (4%) 1 (2%) 2 (4%)
Fatty Change, Multifocal 1 (2%) 3 (6%) 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 2 (4%) 1 (2%)
Inflammation, Granulomatous, Multifocal 13 (26%) 6 (12%) 5 (10%)
Leukocytosis 1 (2%)
Mixed Cell Focus 3 (6%)
Pigmentation, Hemosiderin 1 (2%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 42 (84%) 46 (92%) 46 (92%)
Centrilobular, Fatty Change 3 (6%)
Centrilobular, Necrosis 3 (6%) 2 (4%) 5 (10%)
Periportal, Fatty Change 4 (8%) 2 (4%) 1 (2%)
Periportal, Fibrosis 1 (2%)
Mesentery (13) (8) (10)
Thrombosis 1 (10%)
Artery, Inflammation, Chronic 1 (10%)
Fat, Necrosis, Focal 11 (85%) 8 (100%) 8 (80%)
Fat, Necrosis, Multifocal 2 (15%)
Pancreas (49) (48) (50)
Ectopic Tissue 1 (2%)
Necrosis, Focal 1 (2%)
Acinus, Atrophy 9 (18%) 10 (21%) 11 (22%)
Acinus, Hyperplasia, Focal 2 (4%) 4 (8%)
Acinus, Hyperplasia, Multifocal 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 4 (8%) 2 (4%)
Salivary Glands (50) (49) (49)
Inflammation, Chronic 1 (2%)
Adventitia, Fibrosis 1 (2%)
Stomach, Forestomach (50) (48) (50)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (50) (48) (50)
Degeneration, Cystic 38 (76%) 33 (69%) 39 (78%)
Erosion 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 25 (50%) 36 (72%) 31 (62%)
Dilatation 2 (4%)
Mineralization 1 (2%)
Aortic Valve, Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 2 (4%) 4 (8%) 2 (4%)
Epicardium, Inflammation, Subacute 1 (2%)
Myocardium, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49)
Atrophy 1 (2%)
Hyperplasia, Focal 4 (8%) 4 (8%) 1 (2%)
Hyperplasia, Multifocal 1 (2%)
Hypertrophy 1 (2%)
Necrosis, Focal 1 (2%)
Vacuolization Cytoplasmic, Diffuse 2 (4%)
Vacuolization Cytoplasmic, Focal 8 (16%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 1 (2%) 2 (4%)
Bilateral, Hyperplasia, Focal 1 (2%)
Bilateral, Vacuolization Cytoplasmic, Focal 2 (4%)
Adrenal Gland, Medulla (43) (47) (44)
Hyperplasia, Focal 1 (2%) 4 (9%) 2 (5%)
Hyperplasia, Multifocal 2 (4%) 1 (2%)
Bilateral, Hyperplasia, Focal 1 (2%)
Pituitary Gland (49) (46) (48)
Angiectasis 1 (2%) 2 (4%)
Cyst 4 (8%) 3 (7%) 2 (4%)
Hemorrhage 1 (2%) 3 (7%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Pars Distalis, Hyperplasia, Focal 4 (8%) 1 (2%) 6 (13%)
Thyroid Gland (50) (48) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 3 (6%) 1 (2%) 3 (6%)
Follicle, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Necrosis, Fibrinoid 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (42) (47) (42)
Hyperplasia 1 (2%)
Inflammation, Chronic 2 (5%) 1 (2%)
Inflammation, Chronic Active 4 (10%) 6 (13%) 8 (19%)
Duct, Ectasia 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (50) (50)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hyperplasia, Focal 7 (14%) 10 (20%) 3 (6%)
Hyperplasia, Multifocal 3 (6%) 4 (8%)
Inflammation, Chronic 3 (6%)
Inflammation, Chronic Active 7 (14%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (50) (48) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Testes (50) (50) (49)
Giant Cell 1 (2%)
Granuloma Sperm 1 (2%) 1 (2%)
Hypospermia 5 (10%) 8 (16%) 3 (6%)
Arteriole, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 10 (20%) 11 (22%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Atrophy 2 (4%)
Necrosis 1 (2%)
Lymph Node (50) (49) (50)
Inguinal, Sinus, Ectasia 1 (2%)
Mediastinal, Hemorrhage 7 (14%) 6 (12%) 9 (18%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Mediastinal, Sinus, Ectasia 1 (2%) 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (44) (42) (47)
Hemorrhage 1 (2%) 2 (5%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 5 (12%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Adventitia, Fibrosis 1 (2%)
Sinus, Ectasia 1 (2%) 3 (7%) 2 (4%)
Lymph Node, Mesenteric (48) (43) (43)
Hemorrhage 2 (4%) 5 (12%) 3 (7%)
Sinus, Ectasia 6 (13%) 5 (12%) 5 (12%)
Spleen (50) (49) (50)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%)
Fibrosis 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 4 (8%)
Hyperplasia, Focal, Re Cell 1 (2%)
Infarct 1 (2%)
Necrosis 1 (2%)
Red Pulp, Atrophy 1 (2%)
Thymus (37) (38) (39)
Hemorrhage 3 (8%) 1 (3%) 2 (5%)
Epithelial Cell, Hyperplasia 19 (51%) 24 (63%) 18 (46%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (29) (26) (32)
Galactocele 1 (4%) 1 (3%)
Duct, Ectasia 1 (3%) 3 (12%) 3 (9%)
Skin (50) (50) (48)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (3) (3)
Cranium, Fibrous Osteodystrophy 1 (33%)
Femur, Fibrous Osteodystrophy 1 (33%)
Femur, Proliferation, Focal 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Brain Stem, Compression 4 (8%) 2 (4%) 4 (8%)
Brain Stem, Hemorrhage 1 (2%)
Brain Stem, Pigmentation, Hemosiderin 1 (2%)
Cerebrum, Gliosis, Focal 1 (2%)
Cerebrum, Hemorrhage 1 (2%) 1 (2%)
Cerebrum, Pigmentation, Hemosiderin 1 (2%)
Pons, Hemorrhage 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50)
Congestion 6 (12%) 3 (6%) 6 (12%)
Hemorrhage 3 (6%) 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 25 (50%) 18 (37%) 22 (44%)
Inflammation, Focal, Granulomatous 1 (2%) 2 (4%)
Inflammation, Granulomatous, Multifocal 1 (2%) 7 (14%) 6 (12%)
Pigmentation 26 (52%) 19 (39%) 23 (46%)
Alveolar Epithelium, Hyperplasia, Focal 13 (26%) 6 (12%) 8 (16%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%) 3 (6%) 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%) 1 (2%)
Interstitium, Inflammation 2 (4%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Peribronchiolar, Alveolus, Inflammation,
Suppurative 1 (2%) 1 (2%)
Nose (50) (50) (50)
Congestion 1 (2%)
Foreign Body 2 (4%) 3 (6%)
Fungus 4 (8%) 4 (8%) 5 (10%)
Hemorrhage 2 (4%)
Hyperkeratosis, Focal 1 (2%) 1 (2%)
Inflammation, Suppurative 10 (20%) 9 (18%) 13 (26%)
Trachea (50) (49) (50)
Hemorrhage 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (3) (4) (2)
Cataract 2 (67%) 4 (100%) 1 (50%)
Necrosis 1 (50%)
Retina, Degeneration 2 (67%) 3 (75%) 1 (50%)
Sclera, Metaplasia, Osseous 2 (67%) 3 (75%)
Harderian Gland (1) (1)
Pigmentation, Porphyrin 1 (100%)
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URINARY SYSTEM
Kidney (50) (50) (50)
Hydronephrosis 1 (2%)
Necrosis 1 (2%) 1 (2%)
Nephropathy 45 (90%) 44 (88%) 43 (86%)
Bilateral, Pelvis, Inflammation, Chronic
Active 1 (2%)
Papilla, Mineralization 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Epithelium, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Epithelium, Hyperplasia, Focal 18 (36%)
Renal Tubule, Epithelium, Hyperplasia,
Multifocal 4 (8%)
Urinary Bladder (49) (49) (50)
Dilatation 2 (4%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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