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https://ntp.niehs.nih.gov/go/3494

TR 391 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                    TRIS 2-CHLOROETHYL PHOSPHATE


NTP Experiment-Test: 05042-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 14:55:41




       Facility:  Microbiological Associates

       Chemical CAS #:  115-96-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10            9                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            4            7                                                  
    Moribund                                           8           10           22                                                  
    Accident                                           1                         1                                                  
    Gavage Death                                                    3            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           33           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (49)         (50)                                                
      Angiectasis                                      3 (6%)       1 (2%)                                                          
      Basophilic Focus                                16 (32%)     19 (39%)      9 (18%)                                            
      Congestion                                                    1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Fatty Change, Diffuse                            2 (4%)       4 (8%)       3 (6%)                                             
      Fatty Change, Focal                              1 (2%)       1 (2%)       2 (4%)                                             
      Fatty Change, Multifocal                                      2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 5 (10%)      1 (2%)       2 (4%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       3 (6%)       6 (12%)                                            
      Hepatodiaphragmatic Nodule, Multiple                          2 (4%)                                                          
      Inflammation, Focal, Necrotizing                              1 (2%)                                                          
      Inflammation, Granulomatous, Multifocal         10 (20%)     14 (29%)      6 (12%)                                            
      Necrosis, Multifocal                             1 (2%)       2 (4%)       2 (4%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Regeneration                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                          24 (48%)     26 (53%)     28 (56%)                                            
      Centrilobular, Degeneration                                                1 (2%)                                             
      Centrilobular, Fatty Change                                                2 (4%)                                             
      Centrilobular, Necrosis                          3 (6%)       1 (2%)       1 (2%)                                             
      Periportal, Fatty Change                                                   1 (2%)                                             
   Mesentery                                          (4)          (4)          (1)                                                 
      Fat, Necrosis, Focal                             4 (100%)     4 (100%)                                                        
   Pancreas                                           (49)         (49)         (50)                                                
      Acinus, Atrophy                                  6 (12%)     11 (22%)      7 (14%)                                            
   Stomach, Forestomach                               (50)         (50)         (49)                                                
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Ulcer                                                                      2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Degeneration, Cystic                            34 (68%)     36 (72%)     36 (72%)                                            
      Erosion                                          1 (2%)                    1 (2%)                                             
      Erosion, Multifocal                                           1 (2%)       1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Submucosa, Fibrosis                                                        1 (2%)                                             
   Tooth                                              (1)                                                                           
      Pulp, Inflammation, Necrotizing                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  11 (22%)      8 (16%)     15 (30%)                                            
      Coronary Artery, Inflammation, Chronic                        1 (2%)                                                          
      Endocardium, Thrombosis                                                    1 (2%)                                             
      Epicardium, Inflammation, Chronic Active         1 (2%)                                                                       
      Myocardium, Inflammation, Multifocal,                                                                                         
          Subacute                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Angiectasis                                                                2 (4%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Focal                               4 (8%)       2 (4%)       4 (8%)                                             
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse                                         2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 6 (13%)      5 (10%)      5 (10%)                                            
      Vacuolization Cytoplasmic, Multifocal            1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (43)         (41)         (45)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)       2 (5%)                                                          
      Hyperplasia, Multifocal                                       2 (5%)       2 (4%)                                             
      Bilateral, Hyperplasia, Focal                    1 (2%)                                                                       
   Pituitary Gland                                    (49)         (49)         (47)                                                
      Angiectasis                                      4 (8%)      10 (20%)     10 (21%)                                            
      Cyst                                            11 (22%)     14 (29%)      8 (17%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Pigmentation, Hemosiderin                                                  2 (4%)                                             
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                3 (6%)       5 (10%)      2 (4%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                              8 (16%)      6 (12%)      5 (10%)                                            
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (34)         (35)         (32)                                                
      Hyperplasia                                                   1 (3%)       3 (9%)                                             
      Inflammation, Chronic                            1 (3%)                                                                       
      Inflammation, Chronic Active                     3 (9%)                    2 (6%)                                             
      Duct, Ectasia                                    1 (3%)       4 (11%)      7 (22%)                                            
   Ovary                                              (49)         (50)         (50)                                                
      Cyst                                             2 (4%)                    1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Decidual Reaction                                             1 (2%)                                                          
      Hydrometra                                       1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                                  2 (4%)                                             
      Cervix, Cyst                                                  1 (2%)                                                          
      Endometrium, Cyst                                             2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                                                1 (2%)                                             
   Lymph Node                                         (50)         (49)         (49)                                                
      Bronchial, Hemorrhage                            1 (2%)                                                                       
      Bronchial, Hyperplasia, Plasma Cell                                        1 (2%)                                             
      Bronchial, Hyperplasia, Re Cell                  1 (2%)                                                                       
      Mediastinal, Hemorrhage                          2 (4%)       5 (10%)      4 (8%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Pigmentation, Hemosiderin           1 (2%)                                                                       
   Lymph Node, Mandibular                             (47)         (45)         (47)                                                
      Hemorrhage                                       1 (2%)       3 (7%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Plasma Cell                         2 (4%)       2 (4%)       3 (6%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (45)         (49)                                                
      Hemorrhage                                       2 (4%)       2 (4%)       1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Sinus, Ectasia                                                             2 (4%)                                             
   Spleen                                             (50)         (49)         (50)                                                
      Hematopoietic Cell Proliferation                 8 (16%)      2 (4%)       6 (12%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                         1 (2%)                    2 (4%)                                             
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
   Thymus                                             (37)         (42)         (39)                                                
      Cyst                                                                       2 (5%)                                             
      Hemorrhage                                       1 (3%)       3 (7%)       5 (13%)                                            
      Epithelial Cell, Hyperplasia                    22 (59%)     29 (69%)     20 (51%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (46)         (47)                                                
      Galactocele                                      2 (4%)       3 (7%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Duct, Ectasia                                    6 (13%)      5 (11%)      2 (4%)                                             
   Skin                                               (50)         (49)         (49)                                                
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Ulcer, Multifocal                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (2)          (1)          (2)                                                 
      Osteopetrosis                                    2 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Brain Stem, Compression                          5 (10%)      7 (14%)      1 (2%)                                             
      Brain Stem, Gliosis                              1 (2%)                   15 (30%)                                            
      Brain Stem, Hemorrhage                           1 (2%)                   12 (24%)                                            
      Brain Stem, Mineralization                                                 7 (14%)                                            
      Brain Stem, Necrosis                                                       1 (2%)                                             
      Brain Stem, Pigmentation, Hemosiderin            1 (2%)                   17 (34%)                                            
      Cerebellum, Gliosis                              1 (2%)                                                                       
      Cerebellum, Hemorrhage                           1 (2%)                    2 (4%)                                             
      Cerebellum, Necrosis                                                       1 (2%)                                             
      Cerebellum, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Cerebrum, Gliosis                                                         19 (38%)                                            
      Cerebrum, Hemorrhage                             1 (2%)                   17 (34%)                                            
      Cerebrum, Mineralization                                                  15 (30%)                                            
      Cerebrum, Pigmentation, Hemosiderin                                       22 (44%)                                            
      Meninges, Hemorrhage                                                       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Pons, Hemorrhage                                              1 (2%)                                                          
      Pons, Necrosis                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       6 (12%)      1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                    3 (6%)       7 (14%)                                            
      Infiltration Cellular, Histiocyte               33 (66%)     26 (52%)     28 (56%)                                            
      Inflammation, Granulomatous, Multifocal          1 (2%)       3 (6%)                                                          
      Leukocytosis                                                               1 (2%)                                             
      Pigmentation                                    33 (66%)     26 (52%)     28 (56%)                                            
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       8 (16%)      2 (4%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal     2 (4%)       1 (2%)       1 (2%)                                             
      Interstitium, Inflammation                       1 (2%)       1 (2%)       1 (2%)                                             
      Peribronchiolar, Foreign Body                                 1 (2%)       2 (4%)                                             
      Pleura, Inflammation, Chronic Active             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     2 (4%)                                                                       
      Fungus                                           1 (2%)                                                                       
      Hemorrhage                                                    2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                        3 (6%)       2 (4%)       3 (6%)                                             
      Ulcer                                                         1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (2)          (8)                                                 
      Cataract                                         2 (33%)      2 (100%)     4 (50%)                                            
      Necrosis                                                                   1 (13%)                                            
      Bilateral, Cataract                              2 (33%)                                                                      
      Retina, Degeneration                             3 (50%)      2 (100%)     5 (63%)                                            
      Sclera, Metaplasia, Osseous                      1 (17%)                                                                      
   Harderian Gland                                    (1)                       (1)                                                 
      Infiltration Cellular, Lymphocyte                                          1 (100%)                                           
      Pigmentation, Porphyrin                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Calculus Micro Observation Only                  2 (4%)                    5 (10%)                                            
      Cyst                                             1 (2%)                                                                       
      Nephropathy                                     27 (54%)     23 (46%)     32 (64%)                                            
      Pigmentation                                     2 (4%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pelvis, Inflammation, Chronic                                              1 (2%)                                             
      Renal Tubule, Epithelium, Hyperplasia                                      4 (8%)                                             
      Renal Tubule, Epithelium, Hyperplasia, Focal                  3 (6%)      11 (22%)                                            
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                             1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (48)                                                
      Infiltration Cellular, Lymphocyte                2 (4%)       1 (2%)                                                          
      Transitional Epithelium, Hyperplasia, Focal                   2 (4%)                                                          
      Transitional Epithelium, Hyperplasia,                                                                                         
          Papillary                                                 1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            9           10                                                  
    Moribund                                           5            7           14                                                  
    Gavage Death                                       4            1                                                               
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           33           25                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (48)         (50)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Wall, Foreign Body                               1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (47)         (48)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Ulcer, Multifocal                                                          1 (2%)                                             
   Intestine Large, Colon                             (50)         (47)         (49)                                                
      Inflammation, Subacute                                        1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (46)         (47)                                                
      Erosion                                                       1 (2%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      3 (6%)       1 (2%)       1 (2%)                                             
      Basophilic Focus                                13 (26%)      6 (12%)      2 (4%)                                             
      Congestion                                       2 (4%)       1 (2%)       1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)       1 (2%)                                             
      Eosinophilic Focus                                            1 (2%)                                                          
      Fatty Change, Diffuse                            2 (4%)       1 (2%)       4 (8%)                                             
      Fatty Change, Focal                              2 (4%)       1 (2%)       2 (4%)                                             
      Fatty Change, Multifocal                         1 (2%)       3 (6%)       2 (4%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                              3 (6%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       2 (4%)       1 (2%)                                             
      Inflammation, Granulomatous, Multifocal         13 (26%)      6 (12%)      5 (10%)                                            
      Leukocytosis                                     1 (2%)                                                                       
      Mixed Cell Focus                                              3 (6%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          42 (84%)     46 (92%)     46 (92%)                                            
      Centrilobular, Fatty Change                      3 (6%)                                                                       
      Centrilobular, Necrosis                          3 (6%)       2 (4%)       5 (10%)                                            
      Periportal, Fatty Change                         4 (8%)       2 (4%)       1 (2%)                                             
      Periportal, Fibrosis                             1 (2%)                                                                       
   Mesentery                                          (13)         (8)          (10)                                                
      Thrombosis                                                                 1 (10%)                                            
      Artery, Inflammation, Chronic                                              1 (10%)                                            
      Fat, Necrosis, Focal                            11 (85%)      8 (100%)     8 (80%)                                            
      Fat, Necrosis, Multifocal                        2 (15%)                                                                      
   Pancreas                                           (49)         (48)         (50)                                                
      Ectopic Tissue                                   1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Acinus, Atrophy                                  9 (18%)     10 (21%)     11 (22%)                                            
      Acinus, Hyperplasia, Focal                                    2 (4%)       4 (8%)                                             
      Acinus, Hyperplasia, Multifocal                                            1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)       4 (8%)       2 (4%)                                             
   Salivary Glands                                    (50)         (49)         (49)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Adventitia, Fibrosis                                                       1 (2%)                                             
   Stomach, Forestomach                               (50)         (48)         (50)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                    4 (8%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (50)                                                
      Degeneration, Cystic                            38 (76%)     33 (69%)     39 (78%)                                            
      Erosion                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  25 (50%)     36 (72%)     31 (62%)                                            
      Dilatation                                                                 2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Aortic Valve, Inflammation, Chronic                                        1 (2%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Atrium, Thrombosis                               2 (4%)       4 (8%)       2 (4%)                                             
      Epicardium, Inflammation, Subacute                                         1 (2%)                                             
      Myocardium, Inflammation, Subacute                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia, Focal                               4 (8%)       4 (8%)       1 (2%)                                             
      Hyperplasia, Multifocal                                       1 (2%)                                                          
      Hypertrophy                                      1 (2%)                                                                       
      Necrosis, Focal                                                            1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               2 (4%)                                                                       
      Vacuolization Cytoplasmic, Focal                 8 (16%)      1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       1 (2%)       2 (4%)                                             
      Bilateral, Hyperplasia, Focal                    1 (2%)                                                                       
      Bilateral, Vacuolization Cytoplasmic, Focal                                2 (4%)                                             
   Adrenal Gland, Medulla                             (43)         (47)         (44)                                                
      Hyperplasia, Focal                               1 (2%)       4 (9%)       2 (5%)                                             
      Hyperplasia, Multifocal                                       2 (4%)       1 (2%)                                             
      Bilateral, Hyperplasia, Focal                                              1 (2%)                                             
   Pituitary Gland                                    (49)         (46)         (48)                                                
      Angiectasis                                                   1 (2%)       2 (4%)                                             
      Cyst                                             4 (8%)       3 (7%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)       3 (7%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                4 (8%)       1 (2%)       6 (13%)                                            
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Ultimobranchial Cyst                                                       1 (2%)                                             
      C-Cell, Hyperplasia                              3 (6%)       1 (2%)       3 (6%)                                             
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Necrosis, Fibrinoid                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (42)         (47)         (42)                                                
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                            2 (5%)                    1 (2%)                                             
      Inflammation, Chronic Active                     4 (10%)      6 (13%)      8 (19%)                                            
      Duct, Ectasia                                    1 (2%)       1 (2%)       1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Cytoplasmic Alteration                                        1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                               7 (14%)     10 (20%)      3 (6%)                                             
      Hyperplasia, Multifocal                                       3 (6%)       4 (8%)                                             
      Inflammation, Chronic                            3 (6%)                                                                       
      Inflammation, Chronic Active                                  7 (14%)     10 (20%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (50)         (48)         (50)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Artery, Inflammation, Chronic                                              1 (2%)                                             
   Testes                                             (50)         (50)         (49)                                                
      Giant Cell                                                                 1 (2%)                                             
      Granuloma Sperm                                  1 (2%)       1 (2%)                                                          
      Hypospermia                                      5 (10%)      8 (16%)      3 (6%)                                             
      Arteriole, Inflammation, Chronic                 1 (2%)       1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                  10 (20%)     11 (22%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Atrophy                                          2 (4%)                                                                       
      Necrosis                                                      1 (2%)                                                          
   Lymph Node                                         (50)         (49)         (50)                                                
      Inguinal, Sinus, Ectasia                         1 (2%)                                                                       
      Mediastinal, Hemorrhage                          7 (14%)      6 (12%)      9 (18%)                                            
      Mediastinal, Pigmentation, Hemosiderin                        1 (2%)       2 (4%)                                             
      Mediastinal, Sinus, Ectasia                      1 (2%)       1 (2%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
   Lymph Node, Mandibular                             (44)         (42)         (47)                                                
      Hemorrhage                                       1 (2%)       2 (5%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Plasma Cell                         1 (2%)       5 (12%)      3 (6%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Adventitia, Fibrosis                                                       1 (2%)                                             
      Sinus, Ectasia                                   1 (2%)       3 (7%)       2 (4%)                                             
   Lymph Node, Mesenteric                             (48)         (43)         (43)                                                
      Hemorrhage                                       2 (4%)       5 (12%)      3 (7%)                                             
      Sinus, Ectasia                                   6 (13%)      5 (12%)      5 (12%)                                            
   Spleen                                             (50)         (49)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Depletion Lymphoid                                            1 (2%)                                                          
      Fibrosis                                         4 (8%)       2 (4%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       4 (8%)                                             
      Hyperplasia, Focal, Re Cell                                                1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Red Pulp, Atrophy                                             1 (2%)                                                          
   Thymus                                             (37)         (38)         (39)                                                
      Hemorrhage                                       3 (8%)       1 (3%)       2 (5%)                                             
      Epithelial Cell, Hyperplasia                    19 (51%)     24 (63%)     18 (46%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (29)         (26)         (32)                                                
      Galactocele                                                   1 (4%)       1 (3%)                                             
      Duct, Ectasia                                    1 (3%)       3 (12%)      3 (9%)                                             
   Skin                                               (50)         (50)         (48)                                                
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (3)          (3)                                                 
      Cranium, Fibrous Osteodystrophy                                            1 (33%)                                            
      Femur, Fibrous Osteodystrophy                                              1 (33%)                                            
      Femur, Proliferation, Focal                                   1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Brain Stem, Compression                          4 (8%)       2 (4%)       4 (8%)                                             
      Brain Stem, Hemorrhage                                                     1 (2%)                                             
      Brain Stem, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Cerebrum, Gliosis, Focal                                                   1 (2%)                                             
      Cerebrum, Hemorrhage                                          1 (2%)       1 (2%)                                             
      Cerebrum, Pigmentation, Hemosiderin                                        1 (2%)                                             
      Pons, Hemorrhage                                                           3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Congestion                                       6 (12%)      3 (6%)       6 (12%)                                            
      Hemorrhage                                       3 (6%)       3 (6%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Histiocyte               25 (50%)     18 (37%)     22 (44%)                                            
      Inflammation, Focal, Granulomatous               1 (2%)                    2 (4%)                                             
      Inflammation, Granulomatous, Multifocal          1 (2%)       7 (14%)      6 (12%)                                            
      Pigmentation                                    26 (52%)     19 (39%)     23 (46%)                                            
      Alveolar Epithelium, Hyperplasia, Focal         13 (26%)      6 (12%)      8 (16%)                                            
      Alveolar Epithelium, Hyperplasia, Multifocal     1 (2%)       3 (6%)       1 (2%)                                             
      Bronchiole, Inflammation, Suppurative            1 (2%)                    1 (2%)                                             
      Interstitium, Inflammation                       2 (4%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Peribronchiolar, Alveolus, Inflammation,                                                                                      
           Suppurative                                 1 (2%)                    1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Foreign Body                                                  2 (4%)       3 (6%)                                             
      Fungus                                           4 (8%)       4 (8%)       5 (10%)                                            
      Hemorrhage                                       2 (4%)                                                                       
      Hyperkeratosis, Focal                                         1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                       10 (20%)      9 (18%)     13 (26%)                                            
   Trachea                                            (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (4)          (2)                                                 
      Cataract                                         2 (67%)      4 (100%)     1 (50%)                                            
      Necrosis                                                                   1 (50%)                                            
      Retina, Degeneration                             2 (67%)      3 (75%)      1 (50%)                                            
      Sclera, Metaplasia, Osseous                      2 (67%)      3 (75%)                                                         
   Harderian Gland                                    (1)          (1)                                                              
      Pigmentation, Porphyrin                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Hydronephrosis                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Nephropathy                                     45 (90%)     44 (88%)     43 (86%)                                            
      Bilateral, Pelvis, Inflammation, Chronic                                                                                      
          Active                                                                 1 (2%)                                             
      Papilla, Mineralization                                                    1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                              1 (2%)       1 (2%)                                             
      Renal Tubule, Mineralization                                  1 (2%)                                                          
      Renal Tubule, Epithelium, Hyperplasia                         1 (2%)       1 (2%)                                             
      Renal Tubule, Epithelium, Hyperplasia, Focal                              18 (36%)                                            
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                             4 (8%)                                             
   Urinary Bladder                                    (49)         (49)         (50)                                                
      Dilatation                                                                 2 (4%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05042-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:41  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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