TR 391 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TRIS 2-CHLOROETHYL PHOSPHATE
NTP Experiment-Test: 05042-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 14:55:44
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 9
Early Deaths
Dead 9 4 7
Moribund 8 10 22
Accident 1 1
Gavage Death 3 4
Survivors
Terminal Sacrifice 32 33 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (49) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mesentery (4) (4) (1)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
Pancreas (49) (49) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Salivary Glands (50) (49) (50)
Stomach, Forestomach (50) (50) (49)
Stomach, Glandular (50) (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Endocardium, Schwannoma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (50) (50)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (43) (41) (45)
Pheochromocytoma Benign 2 (5%)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (49) (49) (47)
Carcinoma 1 (2%)
Page 2
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 21 (43%) 14 (29%) 11 (23%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 2 (4%)
C-Cell, Adenoma 2 (4%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (34) (35) (32)
Adenoma 7 (21%) 3 (9%) 4 (13%)
Carcinoma 2 (6%) 4 (11%) 2 (6%)
Ovary (49) (50) (50)
Uterus (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Stromal 9 (18%) 13 (26%) 11 (22%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma Stromal 3 (6%)
Endometrium, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (49) (49)
Lymph Node, Mandibular (47) (45) (47)
Lymph Node, Mesenteric (48) (45) (49)
Spleen (50) (49) (50)
Thymus (37) (42) (39)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (46) (47)
Adenocarcinoma 3 (7%) 3 (7%) 3 (6%)
Adenoma 1 (2%) 1 (2%)
Fibroadenoma 14 (30%) 16 (35%) 13 (28%)
Fibroadenoma, Multiple 3 (7%) 5 (11%) 5 (11%)
Skin (50) (49) (49)
Page 3
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Sarcoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (1) (2)
Osteosarcoma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
Cerebellum, Meninges, Granular Cell Tumor
Benign 2 (4%)
Cerebrum, Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Adrenal Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 2 (4%) 5 (10%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (49) (48)
Page 4
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 14 (28%) 16 (32%) 20 (40%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 44MG/KG 88 MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 46 44
Total Primary Neoplasms 91 95 95
Total Animals with Benign Neoplasms 35 38 32
Total Benign Neoplasms 61 64 58
Total Animals with Malignant Neoplasms 26 25 30
Total Malignant Neoplasms 30 31 37
Total Animals with Metastatic Neoplasms 3 2 1
Total Metastatic Neoplasm 3 2 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 9 10 10
Early Deaths
Dead 6 9 10
Moribund 5 7 14
Gavage Death 4 1
Accident 1
Survivors
Terminal Sacrifice 36 33 25
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (47) (48)
Intestine Small, Duodenum (48) (46) (47)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (48) (46) (47)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (13) (8) (10)
Sarcoma 1 (10%)
Pancreas (49) (48) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Acinus, Adenocarcinoma 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (49) (49)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (48) (50)
Stomach, Glandular (50) (48) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (43) (47) (44)
Pheochromocytoma Malignant 2 (5%) 1 (2%) 5 (11%)
Pheochromocytoma Benign 9 (21%) 15 (32%) 12 (27%)
Pheochromocytoma Benign, Multiple 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%) 5 (11%) 1 (2%)
Islets, Pancreatic (50) (49) (50)
Adenoma 1 (2%) 2 (4%) 3 (6%)
Carcinoma 1 (2%)
Pituitary Gland (49) (46) (48)
Pars Distalis, Adenoma 19 (39%) 16 (35%) 14 (29%)
Pars Distalis, Carcinoma 2 (4%)
Thyroid Gland (50) (48) (50)
C-Cell, Adenoma 14 (28%) 8 (17%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 2 (4%) 3 (6%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (49)
Preputial Gland (42) (47) (42)
Adenoma 1 (2%) 1 (2%)
Carcinoma 3 (7%) 7 (15%) 6 (14%)
Prostate (50) (50) (50)
Adenoma 1 (2%)
Seminal Vesicle (50) (48) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Testes (50) (50) (49)
Bilateral, Interstitial Cell, Adenoma 30 (60%) 30 (60%) 35 (71%)
Interstitial Cell, Adenoma 8 (16%) 11 (22%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Lymph Node (50) (49) (50)
Mediastinal, Sarcoma, Metastatic 1 (2%)
Mediastinal, Sarcoma, Metastatic, Mesentery 1 (2%)
Page 8
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mandibular (44) (42) (47)
Lymph Node, Mesenteric (48) (43) (43)
Spleen (50) (49) (50)
Hemangiosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%) 1 (2%)
Thymus (37) (38) (39)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (29) (26) (32)
Adenocarcinoma 1 (3%)
Fibroadenoma 2 (7%) 1 (4%)
Skin (50) (50) (48)
Basal Cell Adenoma 1 (2%) 1 (2%) 1 (2%)
Basosquamous Tumor Benign 1 (2%)
Keratoacanthoma 3 (6%) 2 (4%)
Squamous Cell Carcinoma 2 (4%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%) 6 (13%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Lipoma, Multiple 1 (2%)
Subcutaneous Tissue, Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (3) (3)
Femur, Osteosarcoma 1 (33%)
Humerus, Osteosarcoma 1 (33%)
Vertebra, Chordoma 1 (33%)
Vertebra, Sarcoma, Metastatic 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Granular Cell Tumor Benign 1 (2%)
Cerebellum, Meninges, Granular Cell Tumor
Benign 2 (4%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 2 (4%)
Sarcoma, Metastatic, Salivary Glands 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 4 (8%) 16 (32%)
Renal Tubule, Adenoma, Multiple 1 (2%) 8 (16%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (49) (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 5 (10%) 14 (28%) 13 (26%)
Mesothelioma Benign 2 (4%) 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05042-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIS 2-CHLOROETHYL PHOSPHATE Date: 09/05/94
Route: GAVAGE Time: 14:55:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 44MG/KG 88 MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 49
Total Primary Neoplasms 109 141 163
Total Animals with Benign Neoplasms 46 46 49
Total Benign Neoplasms 91 108 121
Total Animals with Malignant Neoplasms 16 29 30
Total Malignant Neoplasms 18 33 42
Total Animals with Metastatic Neoplasms 3 7 6
Total Metastatic Neoplasm 3 11 11
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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