TR 391 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Microbiological Assoc. TRIS 2-CHLOROETHYL PHOSPHATE DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 TIME: 15:05:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128 PATHOLOGIST: G. PARKER CAS: 115-96-8 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Microbiological Assoc. TRIS 2-CHLOROETHYL PHOSPHATE DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 TIME: 15:05:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128 PATHOLOGIST: G. PARKER CAS: 115-96-8 RATS(FISCHER344) ---------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Bone Marrow Brain Clitoral Gland Epididymis Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Microbiological Assoc. TRIS 2-CHLOROETHYL PHOSPHATE DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 TIME: 15:05:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01CP9565001 ROUTE: GAVAGE NTP C#: 60128 PATHOLOGIST: G. PARKER CAS: 115-96-8 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF TRIS 2-CHLOROETHYL PHOSPHATE ==================================================================================================== MALE RATS ------------- ORGAN MORPHOLOGY ------- ------------ Adrenal Medulla Pheochromocytoma Benign Pheochromocytoma: Benign, Complex, Malignant, NOS Brain Granular Cell Tumor Benign Kidney: Renal Tubule Adenoma Carcinoma or Adenoma Skin: Subcutaneous Tissue Fibroma Testes Adenoma Thyroid Gland: C-Cell Adenoma Carcinoma or Adenoma Thyroid Gland: Follicular Cell Carcinoma or Adenoma All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated Benign Tumors Malignant Tumors Malignant and Benign Tumors ==================================================================================================== FEMALE RATS ------------- ORGAN MORPHOLOGY ------- ------------ Kidney: Renal Tubule Adenoma Carcinoma or Adenoma Mammary Gland Fibroadenoma Fibroma, Fibroadenoma or Adenoma Pituitary Gland: Pars Distalis or Unspecified Site Adenoma Carcinoma or Adenoma Thyroid Gland: Follicular Cell Carcinoma Carcinoma or Adenoma Uterus Sarcoma Stromal Sarcoma Stromal or Polyp Stromal All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated Benign Tumors Malignant Tumors Malignant and Benign Tumors ==================================================================================================== DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 1 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 10/43 (23%) 21/47 (45%) 13/44 (30%) | 0/43 (0%) 2/41 (5%) 0/45 (0%) | |ADJUSTED (b) | 33.3% 57.8% 43.5% | 0.0% 6.9% 0.0% | |TERMINAL (d) | 10/30 (33%) 17/32 (53%) 8/23 (35%) | 0/28 (0%) 2/29 (7%) 0/16 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 603 528 | --- 729 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.100 P=0.020 * P=0.137 | P=0.562 P=0.246 (e) | |INCIDENTAL TUMOR | P=0.347 P=0.056 P=0.355 | P=0.562 P=0.246 (e) | |LOGISTIC REGRESSION | P=0.305 P=0.037 * P=0.341 | P=0.562 P=0.246 (e) | |COCHRAN-ARMITAGE | P=0.308 | P=0.661N | |FISHER EXACT | P=0.027 * P=0.337 | P=0.235 (e) | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Malignant | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/43 (5%) 1/47 (2%) 5/44 (11%) | 0/43 (0%) 0/41 (0%) 0/45 (0%) | |ADJUSTED (b) | 5.9% 3.1% 21.7% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/30 (3%) 1/32 (3%) 5/23 (22%) | 0/28 (0%) 0/29 (0%) 0/16 (0%) | |FIRST INCIDENCE (DAYS) | 641 729 (T) 729 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.079 P=0.482N P=0.135 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.092 P=0.421N P=0.162 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.118 P=0.448N P=0.204 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.136 | (e) | |FISHER EXACT | P=0.466N P=0.226 | (e) (e) | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 2 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma: Benign, Complex, Malignant, NOS | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 12/43 (28%) 22/47 (47%) 17/44 (39%) | 0/43 (0%) 2/41 (5%) 0/45 (0%) | |ADJUSTED (b) | 38.4% 60.6% 58.6% | 0.0% 6.9% 0.0% | |TERMINAL (d) | 11/30 (37%) 18/32 (56%) 12/23 (52%) | 0/28 (0%) 2/29 (7%) 0/16 (0%) | |FIRST INCIDENCE (DAYS) | 641 603 528 | --- 729 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.036 * P=0.040 * P=0.051 | P=0.562 P=0.246 (e) | |INCIDENTAL TUMOR | P=0.173 P=0.107 P=0.174 | P=0.562 P=0.246 (e) | |LOGISTIC REGRESSION | P=0.170 P=0.073 P=0.199 | P=0.562 P=0.246 (e) | |COCHRAN-ARMITAGE | P=0.180 | P=0.661N | |FISHER EXACT | P=0.051 P=0.202 | P=0.235 (e) | |=================================================================================================================================| | | |Bone | | Osteosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 5.0% 0.0% | 0.0% 2.5% 2.3% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 540 --- | --- 652 492 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.644 P=0.248 (e) | P=0.290 P=0.505 P=0.500 | |INCIDENTAL TUMOR | P=0.517N P=0.362 (e) | P=0.529 P=0.500 P=0.718 | |LOGISTIC REGRESSION | P=0.640 P=0.202 (e) | P=0.354 P=0.502 P=0.538 | |COCHRAN-ARMITAGE | P=0.667 | P=0.332 | |FISHER EXACT | P=0.247 (e) | P=0.500 P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 3 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Brain | | Granular Cell Tumor Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/49 (0%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 0.0% 9.5% | 0.0% 6.1% 0.0% | |TERMINAL (d) | 0/36 (0%) 0/32 (0%) 1/25 (4%) | 0/32 (0%) 2/33 (6%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 575 | --- 729 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.028 * (e) P=0.094 | P=0.549 P=0.245 (e) | |INCIDENTAL TUMOR | P=0.073 (e) P=0.246 | P=0.549 P=0.245 (e) | |LOGISTIC REGRESSION | P=0.037 * (e) P=0.119 | P=0.549 P=0.245 (e) | |COCHRAN-ARMITAGE | P=0.038 * | P=0.667 | |FISHER EXACT | (e) P=0.121 | P=0.247 (e) | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/42 (2%) 0/47 (0%) 1/42 (2%) | 7/34 (21%) 3/35 (9%) 4/32 (13%) | |ADJUSTED (b) | 3.0% 0.0% 4.3% | 30.4% 11.5% 15.2% | |TERMINAL (d) | 1/33 (3%) 0/31 (0%) 1/23 (4%) | 7/23 (30%) 2/22 (9%) 0/9 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 729 (T) 686 555 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.598 P=0.512N P=0.679 | P=0.565N P=0.166N P=0.523 | |INCIDENTAL TUMOR | P=0.598 P=0.512N P=0.679 | P=0.295N P=0.145N P=0.437N | |LOGISTIC REGRESSION | P=0.598 P=0.512N P=0.679 | P=0.370N P=0.145N P=0.534N | |COCHRAN-ARMITAGE | P=0.671N | P=0.213N | |FISHER EXACT | P=0.472N P=0.753N | P=0.141N P=0.292N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 4 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/42 (7%) 7/47 (15%) 6/42 (14%) | 2/34 (6%) 4/35 (11%) 2/32 (6%) | |ADJUSTED (b) | 9.1% 17.2% 17.6% | 5.3% 15.5% 5.2% | |TERMINAL (d) | 3/33 (9%) 2/31 (6%) 1/23 (4%) | 0/23 (0%) 3/22 (14%) 0/9 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 441 575 | 634 310 519 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.148 P=0.165 P=0.165 | P=0.376 P=0.325 P=0.573 | |INCIDENTAL TUMOR | P=0.536 P=0.334 P=0.662 | P=0.542N P=0.443 P=0.334N | |LOGISTIC REGRESSION | P=0.195 P=0.192 P=0.239 | P=0.589 P=0.356 P=0.688N | |COCHRAN-ARMITAGE | P=0.202 | P=0.561 | |FISHER EXACT | P=0.208 P=0.241 | P=0.351 P=0.670 | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/42 (10%) 7/47 (15%) 7/42 (17%) | 9/34 (26%) 7/35 (20%) 6/32 (19%) | |ADJUSTED (b) | 12.1% 17.2% 21.4% | 34.1% 26.4% 19.7% | |TERMINAL (d) | 4/33 (12%) 2/31 (6%) 2/23 (9%) | 7/23 (30%) 5/22 (23%) 0/9 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 441 575 | 634 310 519 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.145 P=0.263 P=0.157 | P=0.427 P=0.423N P=0.447 | |INCIDENTAL TUMOR | P=0.502 P=0.474 P=0.590 | P=0.295N P=0.314N P=0.239N | |LOGISTIC REGRESSION | P=0.211 P=0.316 P=0.253 | P=0.338N P=0.378N P=0.467N | |COCHRAN-ARMITAGE | P=0.214 | P=0.269N | |FISHER EXACT | P=0.330 P=0.260 | P=0.363N P=0.326N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 5 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Heart | | Schwannoma Malignant | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.3% 3.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 1/32 (3%) 1/33 (3%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 582 729 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.212N P=0.493N P=0.337N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.134N P=0.493N P=0.192N | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.153N P=0.503N P=0.239N | |COCHRAN-ARMITAGE | (e) | P=0.142N | |FISHER EXACT | (e) (e) | P=0.500N P=0.247N | |=================================================================================================================================| | | |Islets, Pancreatic | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/49 (4%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 2.8% 6.3% 11.4% | 0.0% 0.0% 5.9% | |TERMINAL (d) | 1/36 (3%) 2/32 (6%) 2/25 (8%) | 0/32 (0%) 0/33 (0%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 700 | --- --- 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.129 P=0.459 P=0.193 | P=0.184 (e) P=0.374 | |INCIDENTAL TUMOR | P=0.225 P=0.459 P=0.373 | P=0.184 (e) P=0.374 | |LOGISTIC REGRESSION | P=0.168 P=0.459 P=0.253 | P=0.184 (e) P=0.374 | |COCHRAN-ARMITAGE | P=0.223 | P=0.271 | |FISHER EXACT | P=0.492 P=0.309 | (e) P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 6 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/49 (4%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 2.8% 6.3% 13.6% | 0.0% 0.0% 5.9% | |TERMINAL (d) | 1/36 (3%) 2/32 (6%) 2/25 (8%) | 0/32 (0%) 0/33 (0%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 630 | --- --- 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.066 P=0.459 P=0.114 | P=0.184 (e) P=0.374 | |INCIDENTAL TUMOR | P=0.129 P=0.459 P=0.249 | P=0.184 (e) P=0.374 | |LOGISTIC REGRESSION | P=0.108 P=0.459 P=0.174 | P=0.184 (e) P=0.374 | |COCHRAN-ARMITAGE | P=0.119 | P=0.271 | |FISHER EXACT | P=0.492 P=0.181 | (e) P=0.500 | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 5/50 (10%) 24/50 (48%) | 0/50 (0%) 2/50 (4%) 5/50 (10%) | |ADJUSTED (b) | 2.8% 15.2% 69.7% | 0.0% 6.1% 29.4% | |TERMINAL (d) | 1/36 (3%) 5/33 (15%) 15/25 (60%) | 0/32 (0%) 2/33 (6%) 5/17 (29%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 575 | --- 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.083 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |INCIDENTAL TUMOR | P<0.001 ** P=0.083 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |LOGISTIC REGRESSION | P<0.001 ** P=0.083 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.017 * | |FISHER EXACT | P=0.102 P<0.001 ** | P=0.247 P=0.028 * | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 7 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 5/50 (10%) 25/50 (50%) | 0/50 (0%) 2/50 (4%) 5/50 (10%) | |ADJUSTED (b) | 5.6% 15.2% 72.7% | 0.0% 6.1% 29.4% | |TERMINAL (d) | 2/36 (6%) 5/33 (15%) 16/25 (64%) | 0/32 (0%) 2/33 (6%) 5/17 (29%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 575 | --- 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.181 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |INCIDENTAL TUMOR | P<0.001 ** P=0.181 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |LOGISTIC REGRESSION | P<0.001 ** P=0.181 P<0.001 ** | P=0.001 ** P=0.245 P=0.003 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.017 * | |FISHER EXACT | P=0.218 P<0.001 ** | P=0.247 P=0.028 * | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 2.7% 8.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 2/25 (8%) | 0/32 (0%) 0/32 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 660 729 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.106 P=0.505 P=0.162 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.202 (e) P=0.162 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.137 P=0.493 P=0.162 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.142 | (e) | |FISHER EXACT | P=0.500 P=0.247 | (e) (e) | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 8 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 2.7% 8.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 2/25 (8%) | 0/32 (0%) 0/32 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 660 729 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.106 P=0.505 P=0.162 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.202 (e) P=0.162 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.137 P=0.493 P=0.162 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.142 | (e) | |FISHER EXACT | P=0.500 P=0.247 | (e) (e) | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/49 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 0.0% 7.0% | 3.1% 3.0% 3.0% | |TERMINAL (d) | 0/36 (0%) 0/32 (0%) 1/25 (4%) | 1/32 (3%) 1/33 (3%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 683 | 729 (T) 729 (T) 596 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.074 (e) P=0.188 | P=0.516 P=0.755N P=0.659 | |INCIDENTAL TUMOR | P=0.166 (e) P=0.427 | P=0.642 P=0.755N P=0.745N | |LOGISTIC REGRESSION | P=0.093 (e) P=0.232 | P=0.613 P=0.755N P=0.756 | |COCHRAN-ARMITAGE | P=0.097 | P=0.640 | |FISHER EXACT | (e) P=0.247 | P=0.753N P=0.753N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 9 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 3/50 (6%) 3/50 (6%) | |ADJUSTED (b) | 2.0% 0.0% 0.0% | 8.4% 8.3% 13.9% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 2/32 (6%) 2/33 (6%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | 350 --- --- | 597 617 687 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.271N P=0.500N P=0.500N | P=0.344 P=0.651N P=0.412 | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.579 P=0.654N P=0.633 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.505 P=0.658 P=0.563 | |COCHRAN-ARMITAGE | P=0.270N | P=0.584 | |FISHER EXACT | P=0.500N P=0.500N | P=0.661N P=0.661N | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 4/50 (8%) 4/50 (8%) | |ADJUSTED (b) | 2.0% 0.0% 0.0% | 8.4% 11.3% 19.3% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 2/32 (6%) 3/33 (9%) 2/17 (12%) | |FIRST INCIDENCE (DAYS) | 350 --- --- | 597 617 687 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.271N P=0.500N P=0.500N | P=0.178 P=0.512 P=0.233 | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.358 P=0.512 P=0.415 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.312 P=0.493 P=0.361 | |COCHRAN-ARMITAGE | P=0.270N | P=0.424 | |FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 10 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Mammary Gland | | Fibroadenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 17/50 (34%) 21/50 (42%) 18/50 (36%) | |ADJUSTED (b) | 5.6% 3.0% 0.0% | 45.5% 53.6% 74.0% | |TERMINAL (d) | 2/36 (6%) 1/33 (3%) 0/25 (0%) | 12/32 (38%) 15/33 (45%) 11/17 (65%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | 619 588 596 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.201N P=0.530N P=0.322N | P=0.017 * P=0.312 P=0.019 * | |INCIDENTAL TUMOR | P=0.201N P=0.530N P=0.322N | P=0.160 P=0.293 P=0.158 | |LOGISTIC REGRESSION | P=0.201N P=0.530N P=0.322N | P=0.089 P=0.253 P=0.084 | |COCHRAN-ARMITAGE | P=0.142N | P=0.458 | |FISHER EXACT | P=0.500N P=0.247N | P=0.268 P=0.500 | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 17/50 (34%) 22/50 (44%) 18/50 (36%) | |ADJUSTED (b) | 5.6% 3.0% 0.0% | 45.5% 56.2% 74.0% | |TERMINAL (d) | 2/36 (6%) 1/33 (3%) 0/25 (0%) | 12/32 (38%) 16/33 (48%) 11/17 (65%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | 619 588 596 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.201N P=0.530N P=0.322N | P=0.016 * P=0.249 P=0.019 * | |INCIDENTAL TUMOR | P=0.201N P=0.530N P=0.322N | P=0.150 P=0.226 P=0.158 | |LOGISTIC REGRESSION | P=0.201N P=0.530N P=0.322N | P=0.083 P=0.190 P=0.084 | |COCHRAN-ARMITAGE | P=0.142N | P=0.458 | |FISHER EXACT | P=0.500N P=0.247N | P=0.206 P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 11 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma, Carcinoma, or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 20/50 (40%) 24/50 (48%) 18/50 (36%) | |ADJUSTED (b) | 7.4% 3.0% 0.0% | 52.1% 59.7% 74.0% | |TERMINAL (d) | 2/36 (6%) 1/33 (3%) 0/25 (0%) | 14/32 (44%) 17/33 (52%) 11/17 (65%) | |FIRST INCIDENCE (DAYS) | 350 729 (T) --- | 597 588 596 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.089N P=0.330N P=0.168N | P=0.052 P=0.323 P=0.059 | |INCIDENTAL TUMOR | P=0.201N P=0.530N P=0.322N | P=0.379 P=0.299 P=0.370 | |LOGISTIC REGRESSION | P=0.070N P=0.342N P=0.144N | P=0.258 P=0.251 P=0.252 | |COCHRAN-ARMITAGE | P=0.060N | P=0.382N | |FISHER EXACT | P=0.309N P=0.121N | P=0.273 P=0.418N | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 19/49 (39%) 16/46 (35%) 14/48 (29%) | 21/49 (43%) 14/49 (29%) 11/47 (23%) | |ADJUSTED (b) | 44.8% 41.4% 42.8% | 57.9% 38.1% 47.6% | |TERMINAL (d) | 13/36 (36%) 11/33 (33%) 8/25 (32%) | 16/31 (52%) 11/33 (33%) 6/16 (38%) | |FIRST INCIDENCE (DAYS) | 403 506 471 | 633 598 492 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.440N P=0.403N P=0.477N | P=0.342N P=0.081N P=0.500N | |INCIDENTAL TUMOR | P=0.116N P=0.282N P=0.197N | P=0.075N P=0.083N P=0.145N | |LOGISTIC REGRESSION | P=0.182N P=0.421N P=0.213N | P=0.095N P=0.091N P=0.165N | |COCHRAN-ARMITAGE | P=0.187N | P=0.026N* | |FISHER EXACT | P=0.425N P=0.217N | P=0.103N P=0.035N* | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 12 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/49 (4%) 0/46 (0%) 0/48 (0%) | 1/49 (2%) 2/49 (4%) 0/47 (0%) | |ADJUSTED (b) | 4.4% 0.0% 0.0% | 2.1% 5.9% 0.0% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 0/31 (0%) 1/33 (3%) 0/16 (0%) | |FIRST INCIDENCE (DAYS) | 419 --- --- | 403 724 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.089N P=0.224N P=0.226N | P=0.462N P=0.506 P=0.500N | |INCIDENTAL TUMOR | P=0.189N P=0.397N P=0.397N | P=0.274N P=0.247 P=0.282N | |LOGISTIC REGRESSION | P=0.257N P=0.502N P=0.484N | P=0.357N P=0.513 P=0.463N | |COCHRAN-ARMITAGE | P=0.099N | P=0.373N | |FISHER EXACT | P=0.263N P=0.253N | P=0.500 P=0.510N | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 21/49 (43%) 16/46 (35%) 14/48 (29%) | 22/49 (45%) 16/49 (33%) 11/47 (23%) | |ADJUSTED (b) | 47.2% 41.4% 42.8% | 58.8% 42.7% 47.6% | |TERMINAL (d) | 13/36 (36%) 11/33 (33%) 8/25 (32%) | 16/31 (52%) 12/33 (36%) 6/16 (38%) | |FIRST INCIDENCE (DAYS) | 403 506 471 | 403 598 492 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.292N P=0.266N P=0.327N | P=0.297N P=0.125N P=0.414N | |INCIDENTAL TUMOR | P=0.064N P=0.194N P=0.125N | P=0.043N* P=0.172N P=0.082N | |LOGISTIC REGRESSION | P=0.102N P=0.314N P=0.127N | P=0.056N P=0.147N P=0.082N | |COCHRAN-ARMITAGE | P=0.096N | P=0.017N* | |FISHER EXACT | P=0.276N P=0.116N | P=0.150N P=0.022N* | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 13 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Skin | | Keratoacanthoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 9.1% 7.1% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 3/33 (9%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 729 (T) 696 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.126 P=0.106 P=0.183 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.392 P=0.106 (e) | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.178 P=0.106 P=0.237 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.201 | (e) | |FISHER EXACT | P=0.121 P=0.247 | (e) (e) | |=================================================================================================================================| | | |Skin | | Squamous Cell Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 6.1% 2.2% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 2/33 (6%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 729 (T) 550 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.308 P=0.219 P=0.528 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.332 P=0.219 P=0.594 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.357 P=0.219 P=0.415 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.360 | (e) | |FISHER EXACT | P=0.247 P=0.500 | (e) (e) | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 14 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Skin | | Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 2.8% 6.1% 2.2% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/36 (3%) 2/33 (6%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 550 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.549 P=0.470 P=0.737 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.574 P=0.470 P=0.754N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.622N P=0.470 P=0.752 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.622 | (e) | |FISHER EXACT | P=0.500 P=0.753N | (e) (e) | |=================================================================================================================================| | | |Skin | | Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, | | Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/50 (4%) 6/50 (12%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 5.6% 18.2% 12.8% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 2/36 (6%) 6/33 (18%) 1/25 (4%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 550 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.157 P=0.105 P=0.234 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.348 P=0.105 P=0.639 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.273 P=0.105 P=0.340 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.289 | (e) | |FISHER EXACT | P=0.134 P=0.339 | (e) (e) | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 15 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 3/50 (6%) 6/50 (12%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 2.8% 9.1% 19.1% | 3.1% 0.0% 0.0% | |TERMINAL (d) | 1/36 (3%) 3/33 (9%) 2/25 (8%) | 1/32 (3%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 674 | 729 (T) --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.016 * P=0.274 P=0.033 * | P=0.337N P=0.494N P=0.626N | |INCIDENTAL TUMOR | P=0.132 P=0.274 P=0.373 | P=0.337N P=0.494N P=0.626N | |LOGISTIC REGRESSION | P=0.030 * P=0.274 P=0.055 | P=0.337N P=0.494N P=0.626N | |COCHRAN-ARMITAGE | P=0.036 * | P=0.270N | |FISHER EXACT | P=0.309 P=0.056 | P=0.500N P=0.500N | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibrosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 5.3% 0.0% 0.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/36 (3%) 0/33 (0%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 603 --- --- | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.107N P=0.238N P=0.271N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.085N P=0.197N P=0.224N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.097N P=0.241N P=0.238N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.095N | (e) | |FISHER EXACT | P=0.247N P=0.247N | (e) (e) | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 16 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, Sarcoma, | | Neurofibroma, or Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 3/50 (6%) 6/50 (12%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 8.0% 9.1% 19.1% | 3.1% 0.0% 0.0% | |TERMINAL (d) | 2/36 (6%) 3/33 (9%) 2/25 (8%) | 1/32 (3%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 603 729 (T) 674 | 729 (T) --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.103 P=0.636 P=0.159 | P=0.337N P=0.494N P=0.626N | |INCIDENTAL TUMOR | P=0.452 P=0.661N P=0.590N | P=0.337N P=0.494N P=0.626N | |LOGISTIC REGRESSION | P=0.173 P=0.647N P=0.243 | P=0.337N P=0.494N P=0.626N | |COCHRAN-ARMITAGE | P=0.179 | P=0.270N | |FISHER EXACT | P=0.661N P=0.243 | P=0.500N P=0.500N | |=================================================================================================================================| | | |Testes | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 38/50 (76%) 41/50 (82%) 42/49 (86%) | | |ADJUSTED (b) | 92.7% 95.3% 95.3% | | |TERMINAL (d) | 33/36 (92%) 31/33 (94%) 23/25 (92%) | | |FIRST INCIDENCE (DAYS) | 505 540 458 | | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.004 ** P=0.166 P=0.006 ** | | |INCIDENTAL TUMOR | P=0.212 P=0.508 P=0.276 | | |LOGISTIC REGRESSION | P=0.292 P=0.615 P=0.332 | | |COCHRAN-ARMITAGE | P=0.134 | | |FISHER EXACT | P=0.312 P=0.166 | | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 17 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/50 (28%) 8/48 (17%) 4/50 (8%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) | |ADJUSTED (b) | 36.4% 25.0% 14.1% | 6.3% 6.1% 17.6% | |TERMINAL (d) | 12/36 (33%) 8/32 (25%) 3/25 (12%) | 2/32 (6%) 2/33 (6%) 3/17 (18%) | |FIRST INCIDENCE (DAYS) | 463 729 (T) 630 | 729 (T) 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.029N* P=0.166N P=0.043N* | P=0.177 P=0.685N P=0.226 | |INCIDENTAL TUMOR | P=0.030N* P=0.181N P=0.042N* | P=0.177 P=0.685N P=0.226 | |LOGISTIC REGRESSION | P=0.006N** P=0.108N P=0.009N** | P=0.177 P=0.685N P=0.226 | |COCHRAN-ARMITAGE | P=0.006N** | P=0.407 | |FISHER EXACT | P=0.135N P=0.009N** | P=0.691N P=0.500 | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 1/48 (2%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 2.2% 8.0% | 3.1% 3.0% 5.9% | |TERMINAL (d) | 0/36 (0%) 0/32 (0%) 2/25 (8%) | 1/32 (3%) 1/33 (3%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | --- 574 729 (T) | 729 (T) 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.110 P=0.523 P=0.162 | P=0.486 P=0.755N P=0.614 | |INCIDENTAL TUMOR | P=0.125 P=0.567 P=0.162 | P=0.486 P=0.755N P=0.614 | |LOGISTIC REGRESSION | P=0.144 P=0.419 P=0.162 | P=0.486 P=0.755N P=0.614 | |COCHRAN-ARMITAGE | P=0.144 | P=0.640 | |FISHER EXACT | P=0.490 P=0.247 | P=0.753N P=0.753N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 18 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/50 (28%) 9/48 (19%) 6/50 (12%) | 3/50 (6%) 3/50 (6%) 4/50 (8%) | |ADJUSTED (b) | 36.4% 26.7% 22.0% | 9.4% 9.1% 23.5% | |TERMINAL (d) | 12/36 (33%) 8/32 (25%) 5/25 (20%) | 3/32 (9%) 3/33 (9%) 4/17 (24%) | |FIRST INCIDENCE (DAYS) | 463 574 630 | 729 (T) 729 (T) 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.110N P=0.237N P=0.147N | P=0.150 P=0.650N P=0.182 | |INCIDENTAL TUMOR | P=0.104N P=0.246N P=0.145N | P=0.150 P=0.650N P=0.182 | |LOGISTIC REGRESSION | P=0.028N* P=0.167N P=0.038N* | P=0.150 P=0.650N P=0.182 | |COCHRAN-ARMITAGE | P=0.029N* | P=0.421 | |FISHER EXACT | P=0.200N P=0.039N* | P=0.661N P=0.500 | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/48 (4%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 2.8% 5.3% 10.6% | 0.0% 2.7% 5.9% | |TERMINAL (d) | 1/36 (3%) 1/32 (3%) 2/25 (8%) | 0/32 (0%) 0/33 (0%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | 729 (T) 574 674 | --- 697 729 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.159 P=0.486 P=0.213 | P=0.218 P=0.500 P=0.374 | |INCIDENTAL TUMOR | P=0.273 P=0.511 P=0.373 | P=0.298 P=0.500 P=0.374 | |LOGISTIC REGRESSION | P=0.224 P=0.487 P=0.279 | P=0.259 P=0.498 P=0.374 | |COCHRAN-ARMITAGE | P=0.224 | P=0.332 | |FISHER EXACT | P=0.485 P=0.309 | P=0.500 P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 19 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/48 (0%) 2/50 (4%) | 0/50 (0%) 2/50 (4%) 3/50 (6%) | |ADJUSTED (b) | 0.0% 0.0% 7.4% | 0.0% 6.1% 16.4% | |TERMINAL (d) | 0/36 (0%) 0/32 (0%) 1/25 (4%) | 0/32 (0%) 2/33 (6%) 2/17 (12%) | |FIRST INCIDENCE (DAYS) | --- --- 696 | --- 729 (T) 718 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.068 (e) P=0.175 | P=0.021 * P=0.245 P=0.040 * | |INCIDENTAL TUMOR | P=0.166 (e) P=0.427 | P=0.032 * P=0.245 P=0.067 | |LOGISTIC REGRESSION | P=0.090 (e) P=0.224 | P=0.023 * P=0.245 P=0.044 * | |COCHRAN-ARMITAGE | P=0.098 | P=0.082 | |FISHER EXACT | (e) P=0.247 | P=0.247 P=0.121 | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/48 (4%) 5/50 (10%) | 0/50 (0%) 3/50 (6%) 4/50 (8%) | |ADJUSTED (b) | 2.8% 5.3% 17.6% | 0.0% 8.6% 22.0% | |TERMINAL (d) | 1/36 (3%) 1/32 (3%) 3/25 (12%) | 0/32 (0%) 2/33 (6%) 3/17 (18%) | |FIRST INCIDENCE (DAYS) | 729 (T) 574 674 | --- 697 718 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.032 * P=0.486 P=0.052 | P=0.008 ** P=0.127 P=0.013 * | |INCIDENTAL TUMOR | P=0.109 P=0.511 P=0.185 | P=0.017 * P=0.127 P=0.023 * | |LOGISTIC REGRESSION | P=0.060 P=0.487 P=0.087 | P=0.011 * P=0.120 P=0.014 * | |COCHRAN-ARMITAGE | P=0.061 | P=0.048 * | |FISHER EXACT | P=0.485 P=0.102 | P=0.121 P=0.059 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 20 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 10/50 (20%) 13/50 (26%) 12/50 (24%) | |ADJUSTED (b) | | 30.0% 34.7% 40.6% | |TERMINAL (d) | | 9/32 (28%) 9/33 (27%) 4/17 (24%) | |FIRST INCIDENCE (DAYS) | | 683 617 394 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.050 P=0.345 P=0.073 | |INCIDENTAL TUMOR | | P=0.310 P=0.340 P=0.321 | |LOGISTIC REGRESSION | | P=0.249 P=0.311 P=0.321 | |COCHRAN-ARMITAGE | | P=0.361 | |FISHER EXACT | | P=0.318 P=0.405 | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 0/50 (0%) 0/50 (0%) 3/50 (6%) | |ADJUSTED (b) | | 0.0% 0.0% 12.6% | |TERMINAL (d) | | 0/32 (0%) 0/33 (0%) 1/17 (6%) | |FIRST INCIDENCE (DAYS) | | --- --- 604 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.015 * (e) P=0.057 | |INCIDENTAL TUMOR | | P=0.053 (e) P=0.145 | |LOGISTIC REGRESSION | | P=0.032 * (e) P=0.099 | |COCHRAN-ARMITAGE | | P=0.038 * | |FISHER EXACT | | (e) P=0.121 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 21 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal or Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 10/50 (20%) 13/50 (26%) 15/50 (30%) | |ADJUSTED (b) | | 30.0% 34.7% 49.2% | |TERMINAL (d) | | 9/32 (28%) 9/33 (27%) 5/17 (29%) | |FIRST INCIDENCE (DAYS) | | 683 617 394 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.009 ** P=0.345 P=0.014 * | |INCIDENTAL TUMOR | | P=0.127 P=0.340 P=0.133 | |LOGISTIC REGRESSION | | P=0.084 P=0.311 P=0.117 | |COCHRAN-ARMITAGE | | P=0.150 | |FISHER EXACT | | P=0.318 P=0.178 | |=================================================================================================================================| | | |All Organs | | Leukemia: Lymphocytic, Monocytic, Mononuclear, | | or Undifferentiated | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 5/50 (10%) 14/50 (28%) 13/50 (26%) | 14/50 (28%) 16/50 (32%) 20/50 (40%) | |ADJUSTED (b) | 12.8% 39.6% 37.3% | 37.4% 38.4% 64.4% | |TERMINAL (d) | 3/36 (8%) 12/33 (36%) 6/25 (24%) | 10/32 (31%) 8/33 (24%) 7/17 (41%) | |FIRST INCIDENCE (DAYS) | 539 620 584 | 335 561 469 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.010 ** P=0.017 * P=0.018 * | P=0.006 ** P=0.441 P=0.006 ** | |INCIDENTAL TUMOR | P=0.060 P=0.024 * P=0.115 | P=0.143 P=0.372 P=0.104 | |LOGISTIC REGRESSION | P=0.033 * P=0.025 * P=0.035 * | P=0.076 P=0.399 P=0.093 | |COCHRAN-ARMITAGE | P=0.033 * | P=0.122 | |FISHER EXACT | P=0.020 * P=0.033 * | P=0.414 P=0.146 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 22 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |All Organs | | Mesothelioma Benign, Malignant, NOS | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 4/50 (8%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 2.3% 10.5% 13.8% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/36 (0%) 2/33 (6%) 2/25 (8%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | 505 603 676 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.105 P=0.190 P=0.133 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.245 P=0.180 P=0.339 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.144 P=0.148 P=0.177 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.146 | (e) | |FISHER EXACT | P=0.181 P=0.181 | (e) (e) | |=================================================================================================================================| | | |All Organs | | Osteosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 5.0% 0.0% | 0.0% 2.5% 2.3% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 540 --- | --- 652 492 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.644 P=0.248 (e) | P=0.290 P=0.505 P=0.500 | |INCIDENTAL TUMOR | P=0.517N P=0.362 (e) | P=0.529 P=0.500 P=0.718 | |LOGISTIC REGRESSION | P=0.640 P=0.202 (e) | P=0.354 P=0.502 P=0.538 | |COCHRAN-ARMITAGE | P=0.667 | P=0.332 | |FISHER EXACT | P=0.247 (e) | P=0.500 P=0.500 | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 23 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |All Organs | | Osteosarcoma or Osteoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 5.0% 0.0% | 0.0% 2.5% 2.3% | |TERMINAL (d) | 0/36 (0%) 0/33 (0%) 0/25 (0%) | 0/32 (0%) 0/33 (0%) 0/17 (0%) | |FIRST INCIDENCE (DAYS) | --- 540 --- | --- 652 492 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.644 P=0.248 (e) | P=0.290 P=0.505 P=0.500 | |INCIDENTAL TUMOR | P=0.517N P=0.362 (e) | P=0.529 P=0.500 P=0.718 | |LOGISTIC REGRESSION | P=0.640 P=0.202 (e) | P=0.354 P=0.502 P=0.538 | |COCHRAN-ARMITAGE | P=0.667 | P=0.332 | |FISHER EXACT | P=0.247 (e) | P=0.500 P=0.500 | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 46/50 (92%) 46/50 (92%) 49/50 (98%) | 35/50 (70%) 38/50 (76%) 32/50 (64%) | |ADJUSTED (b) | 100.0% 100.0% 100.0% | 89.7% 90.4% 93.8% | |TERMINAL (d) | 36/36 (100%) 33/33 (100%) 25/25 (100%) | 28/32 (88%) 29/33 (88%) 15/17 (88%) | |FIRST INCIDENCE (DAYS) | 403 506 458 | 619 588 394 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.008 ** P=0.404 P=0.013 * | P=0.003 ** P=0.410 P=0.005 ** | |INCIDENTAL TUMOR | P=0.445 P=0.286N P=0.582 | P=0.262 P=0.377 P=0.270 | |LOGISTIC REGRESSION | P=0.576 P=0.125N P=0.769 | P=0.248 P=0.289 P=0.295 | |COCHRAN-ARMITAGE | P=0.147 | P=0.294N | |FISHER EXACT | P=0.643N P=0.181 | P=0.326 P=0.335N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 24 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | CONTROL 44MG/KG 88 MG/KG | CONTROL 44MG/KG 88 MG/KG | | | MALE LOW MALE HIGHMALE | FEMALE LOW FEM HIGHFEM | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 16/50 (32%) 29/50 (58%) 31/50 (62%) | 26/50 (52%) 25/50 (50%) 30/50 (60%) | |ADJUSTED (b) | 36.6% 65.4% 74.4% | 59.2% 54.2% 82.2% | |TERMINAL (d) | 9/36 (25%) 18/33 (55%) 15/25 (60%) | 15/32 (47%) 12/33 (36%) 11/17 (65%) | |FIRST INCIDENCE (DAYS) | 350 441 528 | 335 85 469 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.016 * P=0.001 ** | P=0.010 ** P=0.478N P=0.008 ** | |INCIDENTAL TUMOR | P=0.007 ** P=0.014 * P=0.009 ** | P=0.460 P=0.514 P=0.383 | |LOGISTIC REGRESSION | P=0.002 ** P=0.006 ** P=0.002 ** | P=0.390 P=0.493 P=0.216 | |COCHRAN-ARMITAGE | P=0.002 ** | P=0.242 | |FISHER EXACT | P=0.008 ** P=0.002 ** | P=0.500N P=0.273 | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 48/50 (96%) 48/50 (96%) 49/50 (98%) | 45/50 (90%) 46/50 (92%) 44/50 (88%) | |ADJUSTED (b) | 100.0% 100.0% 100.0% | 95.7% 97.9% 100.0% | |TERMINAL (d) | 36/36 (100%) 33/33 (100%) 25/25 (100%) | 30/32 (94%) 32/33 (97%) 17/17 (100%) | |FIRST INCIDENCE (DAYS) | 350 441 458 | 335 85 394 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.025 * P=0.419 P=0.035 * | P=0.001 ** P=0.562 P=0.002 ** | |INCIDENTAL TUMOR | P=0.493 P=0.668N P=0.751 | P=0.558N P=0.297 P=0.615N | |LOGISTIC REGRESSION | P=0.557N P=0.458N P=0.661N | P=0.557 P=0.308 P=0.587 | |COCHRAN-ARMITAGE | P=0.391 | P=0.435N | |FISHER EXACT | P=0.691N P=0.500 | P=0.500 P=0.500N | |=================================================================================================================================| DATE: 09/05/94 EXPERIMENT: 05042 TEST: 01 PAGE 25 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TRIS 2-CHLOROETHYL PHOSPHATE TERMINAL SACRIFICE AT 105 WEEKS (a) Number of tumor-bearing animals / number of animals examined at site. (b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for intercurrent mortality. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The incidental tumor test regards these lesions as non-fatal. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fisher's exact tests compare directly the overall incidence rates. For all tests, a negative trend is indicated by "N". (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01). --multipart-boundary Content-type: text/plain Range: bytes 169568-169568/169568 --multipart-boundary--