TR 391 Rat Pathology Tables
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 Facility: Microbiological Associates Chemical CAS #: 115-96-8 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3| DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4| | 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | 2 2 2 2 2 2 2 | Cyst | | Fatty Change, Diffuse | 2 2 | Fatty Change, Focal | 2 | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | | Inflammation, Granulomatous, | | Multifocal | 1 2 2 1 2 | Necrosis, Multifocal | | Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 | Centrilobular, Necrosis | 2 3| __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 | Erosion | 2 | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | | Pulp, Inflammation, Necrotizing | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 | Epicardium, Inflammation, Chronic | | Active | | Myocardium, Inflammation, Multifocal,| | Subacute | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3| DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4| | 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 2 | Vacuolization Cytoplasmic, Focal | 1 2 2 1 | Vacuolization Cytoplasmic, Multifocal| | __________________________________________________________________________| Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + M + M + + + + M +| Hyperplasia, Focal | | Bilateral, Hyperplasia, Focal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + + + + + M + + M + M + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | X X X X X X | Pars Distalis, Angiectasis | 4 | Pars Distalis, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 2 2 1 2 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + M M + + + + M M + + M + + + + + + + M + +| Inflammation, Chronic | 2 | Inflammation, Chronic Active | 4 | Duct, Ectasia | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchial, Hemorrhage | | Bronchial, Hyperplasia, Re Cell | | Mediastinal, Hemorrhage | | Mediastinal, Hyperplasia, Plasma Cell| | Mediastinal, Pigmentation, | | Hemosiderin | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3| DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4| | 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M M + + + + + + + +| Hemorrhage | 3 | Pigmentation | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 4 3 | Necrosis | 3 | __________________________________________________________________________| Thymus | M + + + + + + + + M M + + + M + + + M M + + + + +| Hemorrhage | | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + M + + + + + + + + + + + +| Galactocele | X X | Hemorrhage | | Duct, Ectasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | Osteopetrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 3 3 | Brain Stem, Gliosis | 1 | Brain Stem, Hemorrhage | | Brain Stem, Pigmentation, Hemosiderin| 1 | Cerebellum, Gliosis | 1 | Cerebellum, Hemorrhage | 2 | Cerebellum, Pigmentation, Hemosiderin| 1 | Cerebrum, Hemorrhage | 2 | Pons, Necrosis | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 4 3 2| Edema | | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Granulomatous, | | Multifocal | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3| DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4| | 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia, | | Focal | | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Interstitium, Inflammation | | Pleura, Inflammation, Chronic Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | 3| Inflammation, Suppurative | 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 4 | Bilateral, Cataract | 3 | Retina, Degeneration | 2 3 | Sclera, Metaplasia, Osseous | | __________________________________________________________________________| Harderian Gland | | Pigmentation, Porphyrin | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | 2 | Cyst | X | Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 2 2 1 2| Pigmentation | 3 | __________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9| | 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A A + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A A + + + + + + + A M + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | 2 2 2 2 2 2 2 2 2 | Cyst | X | Fatty Change, Diffuse | | Fatty Change, Focal | | Hematopoietic Cell Proliferation | 1 1 1 1 | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 | Necrosis, Multifocal | 3 | Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 | Centrilobular, Necrosis | 4 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 4 4 | __________________________________________________________________________| Pancreas | + + + + I + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 1 1 1 1 1 2 2 2 1 1 2 2 2 2 1 1 1| Erosion | | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + | Pulp, Inflammation, Necrotizing | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 1 2 2 | Epicardium, Inflammation, Chronic | | Active | 4 | Myocardium, Inflammation, Multifocal,| | Subacute | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9| | 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + M + + + + +| Hyperplasia, Focal | 2 2 2 | Hyperplasia, Multifocal | | Vacuolization Cytoplasmic, Focal | 2 2 | Vacuolization Cytoplasmic, Multifocal| 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + M + + M + + + +| Hyperplasia, Focal | 2 | Bilateral, Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 3 2 | Cyst | X X X X X | Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia, Focal | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + M + M M M + M + + + M M + + + M M +| Inflammation, Chronic | | Inflammation, Chronic Active | 2 4| Duct, Ectasia | | __________________________________________________________________________| Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchial, Hemorrhage | 2 | Bronchial, Hyperplasia, Re Cell | 2 | Mediastinal, Hemorrhage | 2 2 | Mediastinal, Hyperplasia, Plasma Cell| 3 | Mediastinal, Pigmentation, | | Hemosiderin | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9| | 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 2 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Pigmentation | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 3 3 4| Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + M + M M + + + + + + M + + + M M + M| Hemorrhage | 3 | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + M + + + + + + + + + + + + + + +| Galactocele | | Hemorrhage | 2 | Duct, Ectasia | 2 3 3 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + | Osteopetrosis | 4 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 2 | Brain Stem, Gliosis | | Brain Stem, Hemorrhage | 3 | Brain Stem, Pigmentation, Hemosiderin| | Cerebellum, Gliosis | | Cerebellum, Hemorrhage | | Cerebellum, Pigmentation, Hemosiderin| | Cerebrum, Hemorrhage | | Pons, Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 3 | Edema | 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Granulomatous, | | Multifocal | | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9| | 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 3 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 2 2 | Interstitium, Inflammation | 2 | Pleura, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 1 | Fungus | | Inflammation, Suppurative | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + | Cataract | 3 | Bilateral, Cataract | 4 | Retina, Degeneration | 3 | Sclera, Metaplasia, Osseous | 2 | __________________________________________________________________________| Harderian Gland | + | Pigmentation, Porphyrin | 3 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | 1 | Cyst | | Nephropathy | 1 1 2 1 1 1 2 2 2 1 1 1 | Pigmentation | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Intestine Large | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Small | | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 46 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis | | 3 1.7| Basophilic Focus | | 16 2.0| Cyst | | 1 | Fatty Change, Diffuse | | 2 2.0| Fatty Change, Focal | | 1 2.0| Hematopoietic Cell Proliferation | | 5 1.0| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Granulomatous, | | | Multifocal | | 10 1.3| Necrosis, Multifocal | | 1 3.0| Bile Duct, Hyperplasia | | 24 1.9| Centrilobular, Necrosis | | 3 3.0| __________________________________________________________________________|____________| Mesentery | | 4 | Fat, Necrosis, Focal | | 4 4.0| __________________________________________________________________________|____________| Pancreas | | 49 | Acinus, Atrophy | | 6 2.0| __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Degeneration, Cystic | | 34 1.6| Erosion | | 1 2.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | Pulp, Inflammation, Necrotizing | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 11 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Epicardium, Inflammation, Chronic | | | Active | | 1 4.0| Myocardium, Inflammation, Multifocal,| | | Subacute | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 48 | Hyperplasia, Focal | | 4 2.0| Hyperplasia, Multifocal | | 1 2.0| Vacuolization Cytoplasmic, Focal | | 6 1.7| Vacuolization Cytoplasmic, Multifocal| | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 43 | Hyperplasia, Focal | | 1 2.0| Bilateral, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________|____________| Pituitary Gland | | 49 | Angiectasis | | 4 2.0| Cyst | | 11 | Pars Distalis, Angiectasis | | 1 4.0| Pars Distalis, Hyperplasia, Focal | | 3 2.0| __________________________________________________________________________|____________| Thyroid Gland | | 50 | C-Cell, Hyperplasia | | 8 1.5| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 34 | Inflammation, Chronic | | 1 2.0| Inflammation, Chronic Active | | 3 3.3| Duct, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Ovary | | 49 | Cyst | | 2 | __________________________________________________________________________|____________| Uterus | | 50 | Hydrometra | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 50 | Bronchial, Hemorrhage | | 1 2.0| Bronchial, Hyperplasia, Re Cell | | 1 2.0| Mediastinal, Hemorrhage | | 2 2.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0| Mediastinal, Pigmentation, | | | Hemosiderin | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 47 | Hemorrhage | | 1 2.0| Hyperplasia, Plasma Cell | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Hemorrhage | | 2 2.5| Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 8 3.4| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | | 37 | Hemorrhage | | 1 3.0| Epithelial Cell, Hyperplasia | | 22 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 46 | Galactocele | | 2 | Hemorrhage | | 1 2.0| Duct, Ectasia | | 6 2.8| __________________________________________________________________________|____________| Skin | | 50 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 2 | Osteopetrosis | | 2 3.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Brain Stem, Compression | | 5 2.8| Brain Stem, Gliosis | | 1 1.0| Brain Stem, Hemorrhage | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Brain Stem, Pigmentation, Hemosiderin| | 1 1.0| Cerebellum, Gliosis | | 1 1.0| Cerebellum, Hemorrhage | | 1 2.0| Cerebellum, Pigmentation, Hemosiderin| | 1 1.0| Cerebrum, Hemorrhage | | 1 2.0| Pons, Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Congestion | | 6 2.8| Edema | | 1 2.0| Infiltration Cellular, Histiocyte | | 33 1.0| Inflammation, Granulomatous, | | | Multifocal | | 1 2.0| Pigmentation | | 33 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 2 2.5| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 2 2.0| Interstitium, Inflammation | | 1 2.0| Pleura, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Nose | | 50 | Foreign Body | | 2 1.5| Fungus | | 1 3.0| Inflammation, Suppurative | | 3 2.0| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 6 | Cataract | | 2 3.5| Bilateral, Cataract | | 2 3.5| Retina, Degeneration | | 3 2.7| Sclera, Metaplasia, Osseous | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | Pigmentation, Porphyrin | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Calculus Micro Observation Only | | 2 1.5| Cyst | | 1 | Nephropathy | | 27 1.3| Pigmentation | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | | 49 | Infiltration Cellular, Lymphocyte | | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1| | 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 2 2 2 2 2 2 2 2 2 | Congestion | 3 | Fatty Change, Diffuse | 2 2 2 3 | Fatty Change, Focal | 1 | Fatty Change, Multifocal | | Hematopoietic Cell Proliferation | 1| Hepatodiaphragmatic Nodule | X | Hepatodiaphragmatic Nodule, Multiple | X | Inflammation, Focal, Necrotizing | | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 1 | Necrosis, Multifocal | 2 | Pigmentation, Hemosiderin | | Regeneration | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | Centrilobular, Necrosis | 1| __________________________________________________________________________| Mesentery | + | Fat, Necrosis, Focal | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 1 1 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Inflammation, Chronic | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 1 1 1 2 1 2 1 1 1 2 2 1 1 1 1 2 1 1 | Erosion, Multifocal | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 | Coronary Artery, Inflammation, | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1| | 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Necrosis | 4 | Vacuolization Cytoplasmic, Focal | 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + M + M + + + + M + + M + + + + M| Hyperplasia, Focal | 2 2 | Hyperplasia, Multifocal | 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + M + M + + + + + M + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Angiectasis | 3 2 3 2 3 2 | Cyst | X X X X | Hemorrhage | 3 | Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M M + M M M + + M + + + M + + + + + +| Hyperplasia | | Duct, Ectasia | 3 3 4 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Decidual Reaction | X| Cervix, Cyst | | Endometrium, Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 2 2 2| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + M + +| Hemorrhage | | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | Pigmentation, Hemosiderin | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1| | 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3| Capsule, Fibrosis, Focal | | __________________________________________________________________________| Thymus | + M + + + M + + + + M + + + M + + + + + + + + + M| Hemorrhage | 3 | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | X X | Duct, Ectasia | 3 3 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + M + + + + + + + + + +| Ulcer, Multifocal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 2 | Pons, Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 4 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Granulomatous, | | Multifocal | 2 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 2 2 1 | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Interstitium, Inflammation | | Peribronchiolar, Foreign Body | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Suppurative | 3 | Ulcer | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1| | 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | Retina, Degeneration | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 1 2 2 2 1 2 2 2 | Pigmentation | 3 | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | Transitional Epithelium, Hyperplasia,| | Focal | 2 | Transitional Epithelium, Hyperplasia,| | Papillary | 2 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| | 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + M + + + +| Angiectasis | 2 | Basophilic Focus | 2 2 2 2 2 2 2 2 2 2 | Congestion | | Fatty Change, Diffuse | | Fatty Change, Focal | | Fatty Change, Multifocal | 1 1 | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X | Hepatodiaphragmatic Nodule, Multiple | X | Inflammation, Focal, Necrotizing | 1 | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 1 1 1 | Necrosis, Multifocal | 2 | Pigmentation, Hemosiderin | 2 | Regeneration | | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis, Focal | 4 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 1 2 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1| Erosion, Multifocal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 | Coronary Artery, Inflammation, | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| | 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Chronic | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Necrosis | | Vacuolization Cytoplasmic, Focal | 1 1 2 | __________________________________________________________________________| Adrenal Gland, Medulla | M + + M + + + M + + + + + + + + + + + M + + + + +| Hyperplasia, Focal | | Hyperplasia, Multifocal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + M + M + + + + + M + + M + M + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 3 | Cyst | X X X X X X X X X X| Hemorrhage | | Pars Distalis, Hyperplasia, Focal | 2 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + M + + + + + + + + M + + M M M M M + +| Hyperplasia | 3 | Duct, Ectasia | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Decidual Reaction | | Cervix, Cyst | X | Endometrium, Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 2 3 | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + M + + + + M + + + +| Hemorrhage | 2 3 2 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | 3 2 | Pigmentation, Hemosiderin | 2 | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| | 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | M + M + M + + + + + + + + M + + + + + + + + + + +| Hemorrhage | 2 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +| Hematopoietic Cell Proliferation | 3 | Capsule, Fibrosis, Focal | 2 | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + M + M +| Hemorrhage | 3 2 | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + M + + + + + + + + + M + + + + + + + + + +| Galactocele | X | Duct, Ectasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Multifocal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 2 3 2 2 3 | Pons, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Hemorrhage | 4 2| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Granulomatous, | | Multifocal | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 2 | Interstitium, Inflammation | 1 | Peribronchiolar, Foreign Body | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | Inflammation, Suppurative | 2 | Ulcer | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| | 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Retina, Degeneration | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 2 1 2 1 1 1 1 2 1 1| Pigmentation | | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 | Transitional Epithelium, Hyperplasia,| | Focal | 2 | Transitional Epithelium, Hyperplasia,| | Papillary | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Intestine Large | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Small | | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Liver | | 49 | Angiectasis | | 1 2.0| Basophilic Focus | | 19 2.0| Congestion | | 1 3.0| Fatty Change, Diffuse | | 4 2.3| Fatty Change, Focal | | 1 1.0| Fatty Change, Multifocal | | 2 1.0| Hematopoietic Cell Proliferation | | 1 1.0| Hepatodiaphragmatic Nodule | | 3 | Hepatodiaphragmatic Nodule, Multiple | | 2 | Inflammation, Focal, Necrotizing | | 1 1.0| Inflammation, Granulomatous, | | | Multifocal | | 14 1.0| Necrosis, Multifocal | | 2 2.0| Pigmentation, Hemosiderin | | 1 2.0| Regeneration | | 1 2.0| Bile Duct, Hyperplasia | | 26 2.0| Centrilobular, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Mesentery | | 4 | Fat, Necrosis, Focal | | 4 4.0| __________________________________________________________________________|____________| Pancreas | | 49 | Acinus, Atrophy | | 11 1.6| __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 1 2.0| Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Degeneration, Cystic | | 36 1.5| Erosion, Multifocal | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 8 2.0| Coronary Artery, Inflammation, | | | Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 50 | Hyperplasia, Focal | | 2 2.0| Necrosis | | 1 4.0| Vacuolization Cytoplasmic, Focal | | 5 1.6| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 41 | Hyperplasia, Focal | | 2 2.0| Hyperplasia, Multifocal | | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 37 | __________________________________________________________________________|____________| Pituitary Gland | | 49 | Angiectasis | | 10 2.5| Cyst | | 14 | Hemorrhage | | 1 3.0| Pars Distalis, Hyperplasia, Focal | | 5 2.0| __________________________________________________________________________|____________| Thyroid Gland | | 50 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | | 6 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 35 | Hyperplasia | | 1 3.0| Duct, Ectasia | | 4 3.3| __________________________________________________________________________|____________| Ovary | | 50 | __________________________________________________________________________|____________| Uterus | | 50 | Decidual Reaction | | 1 | Cervix, Cyst | | 1 | Endometrium, Cyst | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 49 | Mediastinal, Hemorrhage | | 5 2.2| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 45 | Hemorrhage | | 3 2.3| Hyperplasia, Lymphoid | | 1 3.0| Hyperplasia, Plasma Cell | | 2 2.5| Pigmentation, Hemosiderin | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 45 | Hemorrhage | | 2 2.5| __________________________________________________________________________|____________| Spleen | | 49 | Hematopoietic Cell Proliferation | | 2 3.0| Capsule, Fibrosis, Focal | | 1 2.0| __________________________________________________________________________|____________| Thymus | | 42 | Hemorrhage | | 3 2.7| Epithelial Cell, Hyperplasia | | 29 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 46 | Galactocele | | 3 | Duct, Ectasia | | 5 2.6| __________________________________________________________________________|____________| Skin | | 49 | Ulcer, Multifocal | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Brain Stem, Compression | | 7 2.4| Pons, Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Congestion | | 1 4.0| Hemorrhage | | 3 3.3| Infiltration Cellular, Histiocyte | | 26 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Granulomatous, | | | Multifocal | | 3 2.0| Pigmentation | | 26 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 8 1.9| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 1 2.0| Interstitium, Inflammation | | 1 1.0| Peribronchiolar, Foreign Body | | 1 2.0| __________________________________________________________________________|____________| Nose | | 50 | Hemorrhage | | 2 2.0| Inflammation, Suppurative | | 2 2.5| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 2 2.5| Retina, Degeneration | | 2 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Nephropathy | | 23 1.5| Pigmentation | | 1 3.0| Renal Tubule, Epithelium, | | | Hyperplasia, Focal | | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | | 49 | Infiltration Cellular, Lymphocyte | | 1 2.0| Transitional Epithelium, Hyperplasia,| | | Focal | | 2 2.0| Transitional Epithelium, Hyperplasia,| | | Papillary | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3| DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9| | 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + M + + + + + M M + + M + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 2 3 | Fatty Change, Diffuse | 3 3 | Fatty Change, Focal | | Fatty Change, Multifocal | | Hematopoietic Cell Proliferation | 1 1 | Hepatodiaphragmatic Nodule | X X X X X| Inflammation, Granulomatous, | | Multifocal | 1 | Necrosis, Multifocal | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 | Centrilobular, Degeneration | 2 | Centrilobular, Fatty Change | 2 | Centrilobular, Necrosis | | Periportal, Fatty Change | 2 | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | Inflammation, Acute | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 | Erosion | 2 | Erosion, Multifocal | 2 | Ulcer | | Submucosa, Fibrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 1 1 | Endocardium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3| DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9| | 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 | Hemorrhage | 3| Hyperplasia, Focal | 2 | Necrosis | 3| Vacuolization Cytoplasmic, Diffuse | 2 | Vacuolization Cytoplasmic, Focal | 2 3 2 | Vacuolization Cytoplasmic, Multifocal| 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + M M + I + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia, Multifocal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Angiectasis | 2 2 3 2 2 | Cyst | X X X X | Pigmentation, Hemosiderin | 2 | Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 2 | Follicle, Cyst | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M M M + M + M + + + + M + + + + M + + M + + + +| Hyperplasia | 2 2 | Inflammation, Chronic Active | | Duct, Ectasia | 3 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | | Inflammation, Suppurative | 2 | Endometrium, Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3| DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9| | 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +| Bronchial, Hyperplasia, Plasma Cell | 2 | Mediastinal, Hemorrhage | 2 3| __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + M +| Hemorrhage | 2 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Sinus, Ectasia | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 4 3 4 | Hemorrhage | 4 | Necrosis | 4 4 | __________________________________________________________________________| Thymus | + + + + + + + + + M + M + + + + M + + + M + + + +| Cyst | X | Hemorrhage | 2 3 2| Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + M + + + + + + + + + + + + + + + + +| Galactocele | X | Duct, Ectasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + | Osteopetrosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | | Brain Stem, Gliosis | 2 1 3 3 3 2 2 | Brain Stem, Hemorrhage | 1 2 1 2 1 | Brain Stem, Mineralization | 4 1 | Brain Stem, Necrosis | | Brain Stem, Pigmentation, Hemosiderin| 1 1 1 2 2 2 2 2 | Cerebellum, Hemorrhage | 4 | Cerebellum, Necrosis | | Cerebrum, Gliosis | 3 2 3 1 2 1 2 | Cerebrum, Hemorrhage | 1 2 2 1 3 1 1 1 | Cerebrum, Mineralization | 3 4 2 2 1 | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3| DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9| | 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Cerebrum, Pigmentation, Hemosiderin | 1 2 2 1 1 1 2 1 1 | Meninges, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 4 1 3| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Leukocytosis | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 2 | Interstitium, Inflammation | 1 | Peribronchiolar, Foreign Body | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Suppurative | 3 | Ulcer | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 4 3 | Necrosis | | Retina, Degeneration | 4 3 | __________________________________________________________________________| Harderian Gland | | Infiltration Cellular, Lymphocyte | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | 2 2 2 1 | Nephropathy | 2 1 1 2 2 1 1 1 1 1 2 1 1 | Pelvis, Inflammation, Chronic | 3 | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 1 1 | Renal Tubule, Epithelium, Hyperplasia| 1 | Renal Tubule, Epithelium, | | Hyperplasia, Multifocal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5| DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5| | 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 2 2 2 2 2 | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 2 | Fatty Change, Multifocal | 1 1 | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 | Necrosis, Multifocal | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 1 1 2 2 2 3 2 2 2 2 2 | Centrilobular, Degeneration | | Centrilobular, Fatty Change | 1 | Centrilobular, Necrosis | 3| Periportal, Fatty Change | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 3 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Acute | 3 2 | Ulcer | 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 2 1 1 2 1 1 1 1 1 3 1 1 1 1 2 2 1 2 1 | Erosion | | Erosion, Multifocal | | Ulcer | 3 | Submucosa, Fibrosis | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 1 2 1 1 | Endocardium, Thrombosis | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5| DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5| | 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Angiectasis | 2 | Hematopoietic Cell Proliferation | | Hemorrhage | | Hyperplasia, Focal | 2 2 2 | Necrosis | | Vacuolization Cytoplasmic, Diffuse | 2 | Vacuolization Cytoplasmic, Focal | 1 1 | Vacuolization Cytoplasmic, Multifocal| | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Multifocal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + M + + + + M + + + + + M + M M M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M M + + + + + + + + + + +| Angiectasis | 3 2 2 2 2 | Cyst | X X X X | Pigmentation, Hemosiderin | 2 | Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 | Follicle, Cyst | X | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + + + + M + + M + M M + + + + M + M + M + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 3 2 | Duct, Ectasia | 3 3 3 3 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 | Inflammation, Suppurative | 2 | Endometrium, Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5| DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5| | 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchial, Hyperplasia, Plasma Cell | | Mediastinal, Hemorrhage | 3 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| Hemorrhage | 3 2 | Hyperplasia, Plasma Cell | 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Sinus, Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3| Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + M + + + + + M + + M + + + M + + + + + M M M + +| Cyst | X | Hemorrhage | 1 1| Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Galactocele | X | Duct, Ectasia | 2 | __________________________________________________________________________| Skin | + + + + + + + M + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | Osteopetrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 2 | Brain Stem, Gliosis | 2 1 2 2 2 2 2 2 | Brain Stem, Hemorrhage | 1 1 1 1 2 1 1 | Brain Stem, Mineralization | 3 3 2 3 3 | Brain Stem, Necrosis | 1 | Brain Stem, Pigmentation, Hemosiderin| 2 1 1 1 2 2 1 2 1 | Cerebellum, Hemorrhage | 3 | Cerebellum, Necrosis | 3 | Cerebrum, Gliosis | 1 3 3 2 3 3 1 1 2 2 1 2 | Cerebrum, Hemorrhage | 1 1 1 1 1 1 1 1 1 | Cerebrum, Mineralization | 1 1 1 1 1 2 1 1 1 3 | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5| DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5| | 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Cerebrum, Pigmentation, Hemosiderin | 1 2 2 1 2 1 3 1 1 1 1 1 1 | Meninges, Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 1 4 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Leukocytosis | | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolar Epithelium, Hyperplasia, | | Focal | 3 | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Interstitium, Inflammation | | Peribronchiolar, Foreign Body | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Suppurative | 4 4 | Ulcer | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + | Cataract | 4 4 | Necrosis | 4 | Retina, Degeneration | 4 2 4 | __________________________________________________________________________| Harderian Gland | + | Infiltration Cellular, Lymphocyte | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | 1 | Nephropathy | 1 1 2 1 2 2 1 1 1 3 1 2 1 1 2 1 1 1 1| Pelvis, Inflammation, Chronic | | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 1 2 1 1 1 1 1 1 1 | Renal Tubule, Epithelium, Hyperplasia| 1 1 1 | Renal Tubule, Epithelium, | | Hyperplasia, Multifocal | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Intestine Large | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 49 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Small | | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 45 | __________________________________________________________________________|____________| Liver | | 50 | Basophilic Focus | | 9 2.1| Fatty Change, Diffuse | | 3 2.7| Fatty Change, Focal | | 2 1.5| Fatty Change, Multifocal | | 2 1.0| Hematopoietic Cell Proliferation | | 2 1.0| Hepatodiaphragmatic Nodule | | 6 | Inflammation, Granulomatous, | | | Multifocal | | 6 1.0| Necrosis, Multifocal | | 2 2.0| Bile Duct, Hyperplasia | | 28 1.9| Centrilobular, Degeneration | | 1 2.0| Centrilobular, Fatty Change | | 2 1.5| Centrilobular, Necrosis | | 1 3.0| Periportal, Fatty Change | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | | 50 | Acinus, Atrophy | | 7 1.7| __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 49 | Hyperplasia, Focal | | 1 3.0| Inflammation, Acute | | 2 2.5| Ulcer | | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Degeneration, Cystic | | 36 1.3| Erosion | | 1 2.0| Erosion, Multifocal | | 1 2.0| Ulcer | | 1 3.0| Submucosa, Fibrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 15 1.7| Endocardium, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 50 | Accessory Adrenal Cortical Nodule | | 1 | Angiectasis | | 2 2.0| Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | | 1 3.0| Hyperplasia, Focal | | 4 2.0| Necrosis | | 1 3.0| Vacuolization Cytoplasmic, Diffuse | | 2 2.0| Vacuolization Cytoplasmic, Focal | | 5 1.8| Vacuolization Cytoplasmic, Multifocal| | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 45 | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia, Multifocal | | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 40 | __________________________________________________________________________|____________| Pituitary Gland | | 47 | Angiectasis | | 10 2.2| Cyst | | 8 | Pigmentation, Hemosiderin | | 2 2.0| Pars Distalis, Hyperplasia, Focal | | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | | 50 | C-Cell, Hyperplasia | | 5 1.6| Follicle, Cyst | | 1 | Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 32 | Hyperplasia | | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 2 2.5| Duct, Ectasia | | 7 2.7| __________________________________________________________________________|____________| Ovary | | 50 | Cyst | | 1 | __________________________________________________________________________|____________| Uterus | | 50 | Hydrometra | | 1 3.0| Inflammation, Suppurative | | 2 2.0| Endometrium, Cyst | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 49 | Bronchial, Hyperplasia, Plasma Cell | | 1 2.0| Mediastinal, Hemorrhage | | 4 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 47 | Hemorrhage | | 3 2.3| Hyperplasia, Plasma Cell | | 3 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 49 | Hemorrhage | | 1 1.0| Sinus, Ectasia | | 2 2.0| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 6 3.5| Hemorrhage | | 1 4.0| Necrosis | | 2 4.0| __________________________________________________________________________|____________| Thymus | | 39 | Cyst | | 2 | Hemorrhage | | 5 1.8| Epithelial Cell, Hyperplasia | | 20 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 47 | Galactocele | | 2 | Duct, Ectasia | | 2 2.5| __________________________________________________________________________|____________| Skin | | 49 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Osteopetrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Brain Stem, Compression | | 1 2.0| Brain Stem, Gliosis | | 15 2.1| Brain Stem, Hemorrhage | | 12 1.3| Brain Stem, Mineralization | | 7 2.7| Brain Stem, Necrosis | | 1 1.0| Brain Stem, Pigmentation, Hemosiderin| | 17 1.5| Cerebellum, Hemorrhage | | 2 3.5| Cerebellum, Necrosis | | 1 3.0| Cerebrum, Gliosis | | 19 2.0| Cerebrum, Hemorrhage | | 17 1.2| Cerebrum, Mineralization | | 15 1.7| Cerebrum, Pigmentation, Hemosiderin | | 22 1.4| Meninges, Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Hemorrhage | | 7 2.6| Infiltration Cellular, Histiocyte | | 28 1.0| Leukocytosis | | 1 2.0| Pigmentation | | 28 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 2 2.5| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 1 2.0| Interstitium, Inflammation | | 1 1.0| Peribronchiolar, Foreign Body | | 2 2.0| __________________________________________________________________________|____________| Nose | | 50 | Hemorrhage | | 1 3.0| Inflammation, Suppurative | | 3 3.7| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 8 | Cataract | | 4 3.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | | | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Necrosis | | 1 4.0| Retina, Degeneration | | 5 3.4| __________________________________________________________________________|____________| Harderian Gland | | 1 | Infiltration Cellular, Lymphocyte | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Calculus Micro Observation Only | | 5 1.6| Nephropathy | | 32 1.3| Pelvis, Inflammation, Chronic | | 1 3.0| Renal Tubule, Epithelium, | | | Hyperplasia, Focal | | 11 1.1| Renal Tubule, Epithelium, Hyperplasia| | 4 1.0| Renal Tubule, Epithelium, | | | Hyperplasia, Multifocal | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7| | 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic | | Inflammation, Chronic Active | | Wall, Foreign Body | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + I + + + + + + + + + + + + + + I + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| Artery, Inflammation, Chronic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | 2 2 2 2 | Congestion | 2 | Fatty Change, Diffuse | 1 | Fatty Change, Focal | 2 | Fatty Change, Multifocal | 1 | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 1 1 1 | Leukocytosis | | Pigmentation, Hemosiderin | | Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 | Centrilobular, Fatty Change | 3 1| Centrilobular, Necrosis | 1 2 | Periportal, Fatty Change | | Periportal, Fibrosis | | __________________________________________________________________________| Mesentery | + + + + + +| Fat, Necrosis, Focal | 4 4 4 3| Fat, Necrosis, Multifocal | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| Ectopic Tissue | | Necrosis, Focal | | Acinus, Atrophy | 2 1 2 | Artery, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Inflammation, Chronic, Focal | 2 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7| | 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia, Focal | 2 2 | Hypertrophy | | Vacuolization Cytoplasmic, Diffuse | 2 | Vacuolization Cytoplasmic, Focal | 1 2 1 2 2 | Vacuolization Cytoplasmic, Multifocal| | Bilateral, Hyperplasia, Focal | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + M M M +| Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + M + M + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Cyst | X X | Hemorrhage | | Pars Distalis, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + M M + M M M + + + + + +| Inflammation, Chronic | 2 2 | Inflammation, Chronic Active | 4 | Duct, Ectasia | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 2 2 | Inflammation, Chronic | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7| | 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | Hypospermia | 4 4 | Arteriole, Inflammation, Chronic | 1 | Interstitial Cell, Hyperplasia | 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Sinus, Ectasia | | Mediastinal, Hemorrhage | 2 2 2 | Mediastinal, Sinus, Ectasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + M + + + + + + + + +| Hemorrhage | | Hyperplasia, Plasma Cell | 2 | Sinus, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + + + +| Hemorrhage | | Sinus, Ectasia | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis | 4 | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + M + M I + + + M + + + + + M + + + + + M + + + M| Hemorrhage | 2 | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + M + + + + + M M + M + + M M + + M M + M + +| Duct, Ectasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Fibrosis, Focal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 3 | Brain Stem, Pigmentation, Hemosiderin| 1 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7| | 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 2 3 | Hemorrhage | 2 2| Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Focal, Granulomatous | | Inflammation, Granulomatous, | | Multifocal | | Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Alveolar Epithelium, Hyperplasia, | | Focal | 2 1 2 2 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Bronchiole, Inflammation, Suppurative| | Interstitium, Inflammation | 1 | Peribronchiolar, Alveolus, | | Inflammation, Suppurative | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fungus | 3 3 3 | Hemorrhage | 3 | Inflammation, Suppurative | 2 2 2 2 2 3 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 4 | Retina, Degeneration | 3 | Sclera, Metaplasia, Osseous | 2 2 | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 1 2 1 3 2 2 2 2 2 2 2 2 1 2 2 2 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Inflammation, Chronic | 3 | Inflammation, Chronic Active | 4 | Wall, Foreign Body | 2 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + I I + + + + + + + + + + + + + I + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 2 2 2 2 2 2 2 2 2 | Congestion | 3 | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 | Fatty Change, Multifocal | | Hepatodiaphragmatic Nodule | X X X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 1 1 | Leukocytosis | 2 | Pigmentation, Hemosiderin | 1 | Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Centrilobular, Fatty Change | 2 | Centrilobular, Necrosis | 2 | Periportal, Fatty Change | 1 1 1 1 | Periportal, Fibrosis | 1 | __________________________________________________________________________| Mesentery | + + + + + + + | Fat, Necrosis, Focal | 4 4 4 4 4 4 4 | Fat, Necrosis, Multifocal | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Tissue | X | Necrosis, Focal | 3 | Acinus, Atrophy | 2 1 2 1 2 2 | Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 2 2 2 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Hyperplasia, Focal | 2 2 | Hypertrophy | 3 | Vacuolization Cytoplasmic, Diffuse | 2 | Vacuolization Cytoplasmic, Focal | 1 1 2| Vacuolization Cytoplasmic, Multifocal| 2 | Bilateral, Hyperplasia, Focal | | __________________________________________________________________________| Adrenal Gland, Medulla | + M + + + M + + + + + + + + + + + + + + + + + M +| Hyperplasia, Focal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + M + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Hemorrhage | 2 | Pars Distalis, Hyperplasia, Focal | 2 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + M + M + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | 4 2 2 | Duct, Ectasia | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 3 2 | Inflammation, Chronic | 3 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Hypospermia | 4 3 4 | Arteriole, Inflammation, Chronic | | Interstitial Cell, Hyperplasia | 2 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Sinus, Ectasia | 3 | Mediastinal, Hemorrhage | 2 2 2 3 | Mediastinal, Sinus, Ectasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + M M + + M + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Plasma Cell | | Sinus, Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | Sinus, Ectasia | 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fibrosis | 2 3 3| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + M + M M + + + M M +| Hemorrhage | 3 3| Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + M + M M + + + + M + M M M + + + M + M M +| Duct, Ectasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Fibrosis, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 2 | Brain Stem, Pigmentation, Hemosiderin| | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 2 3 | Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 | Inflammation, Focal, Granulomatous | 2 | Inflammation, Granulomatous, | | Multifocal | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 2 2 1 2 2 3 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 3 | Bronchiole, Inflammation, Suppurative| 2 | Interstitium, Inflammation | 1 | Peribronchiolar, Alveolus, | | Inflammation, Suppurative | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fungus | 2 | Hemorrhage | 2 | Inflammation, Suppurative | 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 4 | Retina, Degeneration | 4 | Sclera, Metaplasia, Osseous | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 3 2 1 1 3 3 1 1 2 2 2 1 1 1 2 2 2 1 2 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | Hemorrhage | | 1 4.0| Inflammation, Chronic | | 1 3.0| Inflammation, Chronic Active | | 1 4.0| Wall, Foreign Body | | 1 2.0| __________________________________________________________________________|____________| Intestine Large | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 45 | __________________________________________________________________________|____________| Intestine Small | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | Artery, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 47 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis | | 3 2.0| Basophilic Focus | | 13 2.0| Congestion | | 2 2.5| Fatty Change, Diffuse | | 2 1.5| Fatty Change, Focal | | 2 1.5| Fatty Change, Multifocal | | 1 1.0| Hepatodiaphragmatic Nodule | | 4 | Inflammation, Granulomatous, | | | Multifocal | | 13 1.0| Leukocytosis | | 1 2.0| Pigmentation, Hemosiderin | | 1 1.0| Bile Duct, Hyperplasia | | 42 1.9| Centrilobular, Fatty Change | | 3 2.0| Centrilobular, Necrosis | | 3 1.7| Periportal, Fatty Change | | 4 1.0| Periportal, Fibrosis | | 1 1.0| __________________________________________________________________________|____________| Mesentery | | 13 | Fat, Necrosis, Focal | | 11 3.9| Fat, Necrosis, Multifocal | | 2 4.0| __________________________________________________________________________|____________| Pancreas | | 49 | Ectopic Tissue | | 1 | Necrosis, Focal | | 1 3.0| Acinus, Atrophy | | 9 1.7| Artery, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 1 2.0| Inflammation, Chronic, Focal | | 1 2.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Degeneration, Cystic | | 38 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 25 2.0| Atrium, Thrombosis | | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 50 | Atrophy | | 1 4.0| Hyperplasia, Focal | | 4 2.0| Hypertrophy | | 1 3.0| Vacuolization Cytoplasmic, Diffuse | | 2 2.0| Vacuolization Cytoplasmic, Focal | | 8 1.5| Vacuolization Cytoplasmic, Multifocal| | 1 2.0| Bilateral, Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 43 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________|____________| Pituitary Gland | | 49 | Cyst | | 4 | Hemorrhage | | 1 2.0| Pars Distalis, Hyperplasia, Focal | | 4 1.8| __________________________________________________________________________|____________| Thyroid Gland | | 50 | C-Cell, Hyperplasia | | 3 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | __________________________________________________________________________|____________| Preputial Gland | | 42 | Inflammation, Chronic | | 2 2.0| Inflammation, Chronic Active | | 4 3.0| Duct, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Prostate | | 50 | Hyperplasia, Focal | | 7 2.1| Inflammation, Chronic | | 3 2.3| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Testes | | 50 | Granuloma Sperm | | 1 3.0| Hypospermia | | 5 3.8| Arteriole, Inflammation, Chronic | | 1 1.0| Interstitial Cell, Hyperplasia | | 10 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Atrophy | | 2 3.0| __________________________________________________________________________|____________| Lymph Node | | 50 | Inguinal, Sinus, Ectasia | | 1 3.0| Mediastinal, Hemorrhage | | 7 2.1| Mediastinal, Sinus, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 44 | Hemorrhage | | 1 2.0| Hyperplasia, Plasma Cell | | 1 2.0| Sinus, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Hemorrhage | | 2 2.0| Sinus, Ectasia | | 6 2.0| __________________________________________________________________________|____________| Spleen | | 50 | Congestion | | 1 3.0| Fibrosis | | 4 3.0| Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Thymus | | 37 | Hemorrhage | | 3 2.7| Epithelial Cell, Hyperplasia | | 19 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 29 | Duct, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Skin | | 50 | Cyst Epithelial Inclusion | | 1 | Fibrosis, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Brain Stem, Compression | | 4 2.8| Brain Stem, Pigmentation, Hemosiderin| | 1 1.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Congestion | | 6 2.7| Hemorrhage | | 3 1.7| Infiltration Cellular, Histiocyte | | 25 1.1| Inflammation, Focal, Granulomatous | | 1 2.0| Inflammation, Granulomatous, | | | Multifocal | | 1 2.0| Pigmentation | | 26 1.1| Alveolar Epithelium, Hyperplasia, | | | Focal | | 13 1.9| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 1 3.0| Bronchiole, Inflammation, Suppurative| | 1 2.0| Interstitium, Inflammation | | 2 1.0| Peribronchiolar, Alveolus, | | | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Nose | | 50 | Congestion | | 1 3.0| Fungus | | 4 2.8| Hemorrhage | | 2 2.5| Inflammation, Suppurative | | 10 2.1| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | | 3 | Cataract | | 2 4.0| Retina, Degeneration | | 2 3.5| Sclera, Metaplasia, Osseous | | 2 2.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Nephropathy | | 45 1.8| __________________________________________________________________________|____________| Urinary Bladder | | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4| | 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Subacute | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + I I + + + I I A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| Erosion | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 2 2 2 2 | Congestion | 2 | Degeneration, Cystic | 1 | Eosinophilic Focus | 2 | Fatty Change, Diffuse | 4 | Fatty Change, Focal | | Fatty Change, Multifocal | 2 | Hematopoietic Cell Proliferation | 1 | Hemorrhage | 3 | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 2 | Mixed Cell Focus | 2 2 | Pigmentation, Hemosiderin | | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Centrilobular, Necrosis | | Periportal, Fatty Change | 2 | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis, Focal | 3 4 4 4 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 2 2 1 1 1| Acinus, Hyperplasia, Focal | 2 | Artery, Inflammation, Chronic | 4 3 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Ulcer | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 1 1 1 2 2 1 1 2 2 1 2 1 2 1 | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4| | 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Atrium, Thrombosis | 2 2 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 3 | Hyperplasia, Multifocal | 3 | Vacuolization Cytoplasmic, Focal | | Vacuolization Cytoplasmic, Multifocal| 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + M + + + + +| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M M + + M + M + + + + + + M + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Angiectasis | 2 | Cyst | X X X | Hemorrhage | 2 | Pigmentation, Hemosiderin | 2 | Pars Distalis, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | | Follicle, Cyst | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 1 | Duct, Ectasia | 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | 3 | Hyperplasia, Focal | 3 2 2 3 2 3 2 | Hyperplasia, Multifocal | | Inflammation, Chronic Active | 2 3 2 2 2 | Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4| | 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granuloma Sperm | 3 | Hypospermia | 2 4 4 4 4| Arteriole, Inflammation, Chronic | | Interstitial Cell, Hyperplasia | 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +| Mediastinal, Hemorrhage | 2 2 | Mediastinal, Pigmentation, | | Hemosiderin | 3 | Mediastinal, Sinus, Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + M + + + + + + + + M + + + + M + M M| Hemorrhage | 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 3 | Pigmentation, Hemosiderin | | Sinus, Ectasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + I + + + + A + + + + + + M + + + + + + + +| Hemorrhage | 2 2 2 | Sinus, Ectasia | 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | 2 3 | Hematopoietic Cell Proliferation | 3 | Infarct | 4 | Red Pulp, Atrophy | | __________________________________________________________________________| Thymus | + + + M + + M + + + + + + + M M + M + M M + + + +| Hemorrhage | 2 | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + M M + + + + M + + M + M + + M + + M M| Galactocele | | Duct, Ectasia | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | Femur, Proliferation, Focal | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4| | 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 | Cerebrum, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | Inflammation, Granulomatous, | | Multifocal | 2 1 2 | Pigmentation | 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 3 1 2 2 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Interstitium, Inflammation | 3 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | 2 | Hyperkeratosis, Focal | | Inflammation, Suppurative | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 4 | Retina, Degeneration | 3 4 | Sclera, Metaplasia, Osseous | 3 3 | __________________________________________________________________________| Harderian Gland | | Pigmentation, Porphyrin | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Necrosis | 3 | Nephropathy | 1 2 2 1 2 3 2 1 2 2 2 3 1 2 2 1 2 1 4 2 2 2 1 | Renal Tubule, Hyperplasia, Focal | 1 | Renal Tubule, Mineralization | | Renal Tubule, Epithelium, Hyperplasia| 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 2 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7| | 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4| __________________________________________________________________________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + A + +| Inflammation, Subacute | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small | + + + + + + A + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + A A +| Erosion | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | 2 2 | Congestion | | Degeneration, Cystic | 2 | Eosinophilic Focus | | Fatty Change, Diffuse | | Fatty Change, Focal | 2 | Fatty Change, Multifocal | 1 1| Hematopoietic Cell Proliferation | 1 1 | Hemorrhage | | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 | Mixed Cell Focus | 2 | Pigmentation, Hemosiderin | 1 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2| Centrilobular, Necrosis | 4 2 | Periportal, Fatty Change | 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 2 | Acinus, Hyperplasia, Focal | 2 | Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + A + + + + +| Degeneration, Cystic | 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7| | 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 | Hyperplasia, Multifocal | | Vacuolization Cytoplasmic, Focal | 2 | Vacuolization Cytoplasmic, Multifocal| | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia, Focal | 2 2 2 | Hyperplasia, Multifocal | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M M M + + M + + M + + + + M + M + + M + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + I + + + + + + + + + + I + + + + + + I| Angiectasis | | Cyst | | Hemorrhage | 3 4 | Pigmentation, Hemosiderin | | Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 2 | Duct, Ectasia | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | | Hyperplasia, Focal | 2 2 2 | Hyperplasia, Multifocal | 2 2 2 | Inflammation, Chronic Active | 2 4 | Inflammation, Suppurative | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7| | 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granuloma Sperm | | Hypospermia | 4 4 4 | Arteriole, Inflammation, Chronic | 3 | Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 3 2 3 2| Mediastinal, Pigmentation, | | Hemosiderin | | Mediastinal, Sinus, Ectasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + M| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 3 3 2 3 | Pigmentation, Hemosiderin | 2 | Sinus, Ectasia | 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + + + + + + + M +| Hemorrhage | 2 1| Sinus, Ectasia | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 4 | Fibrosis | | Hematopoietic Cell Proliferation | 3 | Infarct | | Red Pulp, Atrophy | 3 | __________________________________________________________________________| Thymus | + + + + + + M + M + + + + + + + M + M + + + + M +| Hemorrhage | | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + + M M M + + + M + M M M + + + M M + M| Galactocele | X | Duct, Ectasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + | Femur, Proliferation, Focal | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7| | 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 | Cerebrum, Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 3 | Hemorrhage | 2 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 1 | Inflammation, Granulomatous, | | Multifocal | 1 1 2 1 | Pigmentation | 1 2 1 1 1 1 1 1 1 2 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 2 2 2 | Interstitium, Inflammation | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 2 | Fungus | 3 2 2 | Hyperkeratosis, Focal | 3 | Inflammation, Suppurative | 2 2 3 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | A + + | Cataract | 4 3 | Retina, Degeneration | 3 | Sclera, Metaplasia, Osseous | 3 | __________________________________________________________________________| Harderian Gland | + | Pigmentation, Porphyrin | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Necrosis | | Nephropathy | 2 3 2 2 1 1 3 3 2 2 3 1 2 1 2 2 2 2 2 2 2| Renal Tubule, Hyperplasia, Focal | | Renal Tubule, Mineralization | 2 | Renal Tubule, Epithelium, Hyperplasia| | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 48 | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Intestine Large | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | | 47 | Inflammation, Subacute | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | | 43 | __________________________________________________________________________|____________| Intestine Small | | 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 46 | Erosion | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | | 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 46 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis | | 1 1.0| Basophilic Focus | | 6 2.0| Congestion | | 1 2.0| Degeneration, Cystic | | 2 1.5| Eosinophilic Focus | | 1 2.0| Fatty Change, Diffuse | | 1 4.0| Fatty Change, Focal | | 1 2.0| Fatty Change, Multifocal | | 3 1.3| Hematopoietic Cell Proliferation | | 3 1.0| Hemorrhage | | 1 3.0| Hepatodiaphragmatic Nodule | | 2 | Inflammation, Granulomatous, | | | Multifocal | | 6 1.2| Mixed Cell Focus | | 3 2.0| Pigmentation, Hemosiderin | | 2 1.5| Bile Duct, Hyperplasia | | 46 2.0| Centrilobular, Necrosis | | 2 2.7| Periportal, Fatty Change | | 2 1.5| __________________________________________________________________________|____________| Mesentery | | 8 | Fat, Necrosis, Focal | | 8 3.9| __________________________________________________________________________|____________| Pancreas | | 48 | Acinus, Atrophy | | 10 1.6| Acinus, Hyperplasia, Focal | | 2 2.0| Artery, Inflammation, Chronic | | 4 3.5| __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach | | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | | 48 | Hyperplasia, Focal | | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | | 48 | Degeneration, Cystic | | 33 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 36 2.0| Atrium, Thrombosis | | 4 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 50 | Hyperplasia, Focal | | 4 2.3| Hyperplasia, Multifocal | | 1 3.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Vacuolization Cytoplasmic, Multifocal| | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 47 | Hyperplasia, Focal | | 4 2.0| Hyperplasia, Multifocal | | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | __________________________________________________________________________|____________| Parathyroid Gland | | 33 | __________________________________________________________________________|____________| Pituitary Gland | | 46 | Angiectasis | | 1 2.0| Cyst | | 3 | Hemorrhage | | 3 3.0| Pigmentation, Hemosiderin | | 1 2.0| Pars Distalis, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | | 48 | C-Cell, Hyperplasia | | 1 2.0| Follicle, Cyst | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 49 | __________________________________________________________________________|____________| Preputial Gland | | 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 6 2.0| Duct, Ectasia | | 1 4.0| __________________________________________________________________________|____________| Prostate | | 50 | Cytoplasmic Alteration | | 1 3.0| Hyperplasia, Focal | | 10 2.3| Hyperplasia, Multifocal | | 3 2.0| Inflammation, Chronic Active | | 7 2.4| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | | 48 | __________________________________________________________________________|____________| Testes | | 50 | Granuloma Sperm | | 1 3.0| Hypospermia | | 8 3.8| Arteriole, Inflammation, Chronic | | 1 3.0| Interstitial Cell, Hyperplasia | | 11 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | | 49 | Mediastinal, Hemorrhage | | 6 2.3| Mediastinal, Pigmentation, | | | Hemosiderin | | 1 3.0| Mediastinal, Sinus, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 42 | Hemorrhage | | 2 2.0| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | | 5 2.8| Pigmentation, Hemosiderin | | 1 2.0| Sinus, Ectasia | | 3 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 43 | Hemorrhage | | 5 1.8| Sinus, Ectasia | | 5 2.0| __________________________________________________________________________|____________| Spleen | | 49 | Depletion Lymphoid | | 1 4.0| Fibrosis | | 2 2.5| Hematopoietic Cell Proliferation | | 2 3.0| Infarct | | 1 4.0| Red Pulp, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Thymus | | 38 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemorrhage | | 1 2.0| Epithelial Cell, Hyperplasia | | 24 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 26 | Galactocele | | 1 | Duct, Ectasia | | 3 2.3| __________________________________________________________________________|____________| Skin | | 50 | Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 3 | Femur, Proliferation, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | Brain Stem, Compression | | 2 3.0| Cerebrum, Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Congestion | | 3 2.7| Hemorrhage | | 3 1.7| Infiltration Cellular, Histiocyte | | 18 1.1| Inflammation, Granulomatous, | | | Multifocal | | 7 1.4| Pigmentation | | 19 1.1| Alveolar Epithelium, Hyperplasia, | | | Focal | | 6 2.0| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 3 2.0| Interstitium, Inflammation | | 2 2.0| __________________________________________________________________________|____________| Nose | | 50 | Foreign Body | | 2 2.0| Fungus | | 4 2.3| Hyperkeratosis, Focal | | 1 3.0| Inflammation, Suppurative | | 9 2.0| __________________________________________________________________________|____________| Trachea | | 49 | Hemorrhage | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 4 | Cataract | | 4 3.5| Retina, Degeneration | | 3 3.3| Sclera, Metaplasia, Osseous | | 3 3.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | Pigmentation, Porphyrin | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Hydronephrosis | | 1 3.0| Necrosis | | 1 3.0| Nephropathy | | 44 1.9| Renal Tubule, Hyperplasia, Focal | | 1 1.0| Renal Tubule, Mineralization | | 1 2.0| Renal Tubule, Epithelium, Hyperplasia| | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | | 49 | Infiltration Cellular, Lymphocyte | | 2 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6| | 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| Hemorrhage | 2 | Ulcer, Multifocal | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 2 | Congestion | | Degeneration, Cystic | | Fatty Change, Diffuse | 1 3 | Fatty Change, Focal | 2 | Fatty Change, Multifocal | | Fibrosis | | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous, | | Multifocal | 1 1 1 | Pigmentation, Hemosiderin | 3 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | Centrilobular, Necrosis | 3 1 | Periportal, Fatty Change | | __________________________________________________________________________| Mesentery | + + + | Thrombosis | | Artery, Inflammation, Chronic | 3 | Fat, Necrosis, Focal | 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 2 2 2 | Acinus, Hyperplasia, Focal | 2 | Acinus, Hyperplasia, Multifocal | | Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Adventitia, Fibrosis | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6| | 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Acute | | Inflammation, Chronic, Focal | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 2 1 1 1 1 2 | Erosion | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2 2| Dilatation | 3 | Mineralization | | Aortic Valve, Inflammation, Chronic | | Artery, Inflammation, Chronic | | Atrium, Thrombosis | | Epicardium, Inflammation, Subacute | 2 | Myocardium, Inflammation, Subacute | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Necrosis, Focal | 2 | Vacuolization Cytoplasmic, Focal | | Vacuolization Cytoplasmic, Multifocal| 2 | Bilateral, Vacuolization Cytoplasmic,| | Focal | 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + M + + +| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | | Bilateral, Hyperplasia, Focal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + M + + + + + + M M + M + + + + M M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Angiectasis | 2 | Cyst | X | Hemorrhage | | Pars Distalis, Hyperplasia, Focal | 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 2 2 | Follicle, Cyst | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6| | 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Necrosis, Fibrinoid | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + M + + + + + M| Hyperplasia | 3 | Inflammation, Chronic | | Inflammation, Chronic Active | 2 3 3 2 3 | Duct, Ectasia | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | 3 | Hyperplasia, Focal | | Hyperplasia, Multifocal | 2 2 2 | Inflammation, Chronic Active | 2 3 2 2 2 3 | Inflammation, Suppurative | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 | Artery, Inflammation, Chronic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + M| Giant Cell | | Hypospermia | 4 | Arteriole, Inflammation, Chronic | | Interstitial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 2 2 2 2 2 | Mediastinal, Pigmentation, | | Hemosiderin | 2 2 | Pancreatic, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Plasma Cell | 3 3 | Adventitia, Fibrosis | | Sinus, Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M +| Hemorrhage | | Sinus, Ectasia | 2 4 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Focal, Re Cell | | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + + M + M + + + + M + + + M + M + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6| | 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + M M + + + M + + + + M + M M + + +| Galactocele | | Duct, Ectasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Fibrosis, Focal | 3 | Hemorrhage | | Inflammation, Chronic, Focal | 2 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | | Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 2 | Brain Stem, Hemorrhage | | Cerebrum, Gliosis, Focal | 3 | Cerebrum, Hemorrhage | 1 | Cerebrum, Pigmentation, Hemosiderin | 1 | Pons, Hemorrhage | 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 2 2 3 | Hemorrhage | | Hyperplasia, Lymphoid | 3 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Focal, Granulomatous | 2 2 | Inflammation, Granulomatous, | | Multifocal | 2 | Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 2 2 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | | Bronchiole, Inflammation, Suppurative| | Interstitium, Inflammation | 2 | Peribronchiolar, Alveolus, | | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6| | 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Suppurative | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 3 | Fungus | 3 3 | Hyperkeratosis, Focal | 3 | Inflammation, Suppurative | 1 3 3 2 2 1 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | Necrosis | | Retina, Degeneration | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | Nephropathy | 2 2 1 2 2 2 2 3 3 3 2 2 3 2 2 2 2 1 2 2 2 2 | Bilateral, Pelvis, Inflammation, | | Chronic Active | 3 | Papilla, Mineralization | 2 | Renal Tubule, Hyperplasia, Focal | 1 | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 2 2 1 1 1 | Renal Tubule, Epithelium, Hyperplasia| 1 | Renal Tubule, Epithelium, | | Hyperplasia, Multifocal | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8| | 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| Hemorrhage | | Ulcer, Multifocal | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + I + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + A A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 2 | Congestion | 3 | Degeneration, Cystic | 1 | Fatty Change, Diffuse | 2 2 | Fatty Change, Focal | 1 | Fatty Change, Multifocal | 1 1 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | | Inflammation, Granulomatous, | | Multifocal | 1 1 | Pigmentation, Hemosiderin | | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 3 2 2| Centrilobular, Necrosis | 2 3 3 | Periportal, Fatty Change | 2 | __________________________________________________________________________| Mesentery | + + + + + + +| Thrombosis | 4 | Artery, Inflammation, Chronic | | Fat, Necrosis, Focal | 4 4 4 4 4 4| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 2 1 2 2 | Acinus, Hyperplasia, Focal | 2 2 2 | Acinus, Hyperplasia, Multifocal | 3 | Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic | | Adventitia, Fibrosis | 3 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8| | 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Acute | 2 | Inflammation, Chronic, Focal | 2 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 1 2 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 | Erosion | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 | Dilatation | 2 | Mineralization | 3 | Aortic Valve, Inflammation, Chronic | 3 | Artery, Inflammation, Chronic | 3 | Atrium, Thrombosis | 3 4 | Epicardium, Inflammation, Subacute | | Myocardium, Inflammation, Subacute | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Necrosis, Focal | | Vacuolization Cytoplasmic, Focal | 2 | Vacuolization Cytoplasmic, Multifocal| 1 | Bilateral, Vacuolization Cytoplasmic,| | Focal | | __________________________________________________________________________| Adrenal Gland, Medulla | + M M + M + + + + + + + + + + + + + + + + + + I +| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 2 | Bilateral, Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + M + + + M M + M + + + M M M + M M + M + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Angiectasis | 2 | Cyst | X | Hemorrhage | 2 | Pars Distalis, Hyperplasia, Focal | 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 1 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8| | 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Necrosis, Fibrinoid | 3 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + M M + M + + + + + M| Hyperplasia | | Inflammation, Chronic | 2 | Inflammation, Chronic Active | 2 1 2 | Duct, Ectasia | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | | Hyperplasia, Focal | 2 2 2 | Hyperplasia, Multifocal | 2 | Inflammation, Chronic Active | 2 3 4 2 | Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | Artery, Inflammation, Chronic | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Giant Cell | 3 | Hypospermia | 2 3 | Arteriole, Inflammation, Chronic | 3 | Interstitial Cell, Hyperplasia | 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 2 3 3 2 | Mediastinal, Pigmentation, | | Hemosiderin | | Pancreatic, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + +| Hyperplasia, Plasma Cell | 3 | Adventitia, Fibrosis | 3 | Sinus, Ectasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | I + + + + + + + + + M + + + M + + + + + + + + +| Hemorrhage | 3 3 2 | Sinus, Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 3 | Hyperplasia, Focal, Re Cell | 4 | Necrosis | | __________________________________________________________________________| Thymus | + + + M + + M + + M M + M + + + + + + + + + + M +| Hemorrhage | 2| _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8| | 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + M M + M M + + + M M + + M + M + + + + M + +| Galactocele | X | Duct, Ectasia | 3 3 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + M + + + + + M| Cyst Epithelial Inclusion | X | Fibrosis, Focal | | Hemorrhage | 3 | Inflammation, Chronic, Focal | | Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + | Cranium, Fibrous Osteodystrophy | 2 | Femur, Fibrous Osteodystrophy | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Compression | 3 3 | Brain Stem, Hemorrhage | 3 | Cerebrum, Gliosis, Focal | | Cerebrum, Hemorrhage | | Cerebrum, Pigmentation, Hemosiderin | | Pons, Hemorrhage | 3| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 4 | Hemorrhage | 2 | Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 | Inflammation, Focal, Granulomatous | | Inflammation, Granulomatous, | | Multifocal | 2 2 1 2 1 | Pigmentation | 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 2 | Alveolar Epithelium, Hyperplasia, | | Multifocal | 2 | Bronchiole, Inflammation, Suppurative| 4 | Interstitium, Inflammation | | Peribronchiolar, Alveolus, | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8| | 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Suppurative | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 1 | Fungus | 2 2 3 | Hyperkeratosis, Focal | | Inflammation, Suppurative | 2 2 3 2 3 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 4 | Necrosis | 4 | Retina, Degeneration | 3 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Nephropathy | 3 2 2 2 3 3 1 2 4 4 2 3 4 2 2 2 2 2 2 2 2| Bilateral, Pelvis, Inflammation, | | Chronic Active | | Papilla, Mineralization | | Renal Tubule, Hyperplasia, Focal | | Renal Tubule, Epithelium, | | Hyperplasia, Focal | 1 1 1 2 2 2 1 1 2 1 2 1 1| Renal Tubule, Epithelium, Hyperplasia| | Renal Tubule, Epithelium, | | Hyperplasia, Multifocal | 2 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Hemorrhage | 3 | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Intestine Large | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | Hemorrhage | | 1 2.0| Ulcer, Multifocal | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Small | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 47 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis | | 1 2.0| Basophilic Focus | | 2 2.0| Congestion | | 1 3.0| Degeneration, Cystic | | 1 1.0| Fatty Change, Diffuse | | 4 2.0| Fatty Change, Focal | | 2 1.5| Fatty Change, Multifocal | | 2 1.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 1 1.0| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Granulomatous, | | | Multifocal | | 5 1.0| Pigmentation, Hemosiderin | | 1 3.0| Bile Duct, Hyperplasia | | 46 2.0| Centrilobular, Necrosis | | 5 2.4| Periportal, Fatty Change | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 10 | Thrombosis | | 1 4.0| Artery, Inflammation, Chronic | | 1 3.0| Fat, Necrosis, Focal | | 8 4.0| __________________________________________________________________________|____________| Pancreas | | 50 | Acinus, Atrophy | | 11 1.8| Acinus, Hyperplasia, Focal | | 4 2.0| Acinus, Hyperplasia, Multifocal | | 1 3.0| Artery, Inflammation, Chronic | | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic | | 1 2.0| Adventitia, Fibrosis | | 1 3.0| __________________________________________________________________________|____________| Stomach | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 2 2.0| Inflammation, Acute | | 1 2.0| Inflammation, Chronic, Focal | | 4 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Degeneration, Cystic | | 39 1.3| Erosion | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 31 2.0| Dilatation | | 2 2.5| Mineralization | | 1 3.0| Aortic Valve, Inflammation, Chronic | | 1 3.0| Artery, Inflammation, Chronic | | 1 3.0| Atrium, Thrombosis | | 2 3.5| Epicardium, Inflammation, Subacute | | 1 2.0| Myocardium, Inflammation, Subacute | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | | 49 | Hyperplasia, Focal | | 1 2.0| Necrosis, Focal | | 1 2.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Vacuolization Cytoplasmic, Multifocal| | 2 1.5| Bilateral, Vacuolization Cytoplasmic,| | | Focal | | 2 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | | 44 | Hyperplasia, Focal | | 2 2.0| Hyperplasia, Multifocal | | 1 2.0| Bilateral, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 30 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Angiectasis | | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 77 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Cyst | | 2 | Hemorrhage | | 1 2.0| Pars Distalis, Hyperplasia, Focal | | 6 2.0| __________________________________________________________________________|____________| Thyroid Gland | | 50 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | | 3 1.7| Follicle, Cyst | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Necrosis, Fibrinoid | | 1 3.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 49 | __________________________________________________________________________|____________| Preputial Gland | | 42 | Hyperplasia | | 1 3.0| Inflammation, Chronic | | 1 2.0| Inflammation, Chronic Active | | 8 2.3| Duct, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Prostate | | 50 | Cytoplasmic Alteration | | 1 3.0| Hyperplasia, Focal | | 3 2.0| Hyperplasia, Multifocal | | 4 2.0| Inflammation, Chronic Active | | 10 2.5| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Infiltration Cellular, Lymphocyte | | 1 2.0| Artery, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Testes | | 49 | Giant Cell | | 1 3.0| Hypospermia | | 3 3.0| Arteriole, Inflammation, Chronic | | 1 3.0| Interstitial Cell, Hyperplasia | | 6 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 50 | Mediastinal, Hemorrhage | | 9 2.2| Mediastinal, Pigmentation, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 78 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemosiderin | | 2 2.0| Pancreatic, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 47 | Hyperplasia, Plasma Cell | | 3 3.0| Adventitia, Fibrosis | | 1 3.0| Sinus, Ectasia | | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 43 | Hemorrhage | | 3 2.7| Sinus, Ectasia | | 5 2.4| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 4 3.0| Hyperplasia, Focal, Re Cell | | 1 4.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | | 39 | Hemorrhage | | 2 2.0| Epithelial Cell, Hyperplasia | | 18 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 32 | Galactocele | | 1 | Duct, Ectasia | | 3 2.7| __________________________________________________________________________|____________| Skin | | 48 | Cyst Epithelial Inclusion | | 1 | Fibrosis, Focal | | 1 3.0| Hemorrhage | | 1 3.0| Inflammation, Chronic, Focal | | 1 2.0| Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 3 | Cranium, Fibrous Osteodystrophy | | 1 2.0| Femur, Fibrous Osteodystrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Brain Stem, Compression | | 4 2.8| Brain Stem, Hemorrhage | | 1 3.0| Cerebrum, Gliosis, Focal | | 1 3.0| Cerebrum, Hemorrhage | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Cerebrum, Pigmentation, Hemosiderin | | 1 1.0| Pons, Hemorrhage | | 3 1.7| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Congestion | | 6 3.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 1 3.0| Infiltration Cellular, Histiocyte | | 22 1.0| Inflammation, Focal, Granulomatous | | 2 2.0| Inflammation, Granulomatous, | | | Multifocal | | 6 1.7| Pigmentation | | 23 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 8 2.0| Alveolar Epithelium, Hyperplasia, | | | Multifocal | | 1 2.0| Bronchiole, Inflammation, Suppurative| | 1 4.0| Interstitium, Inflammation | | 1 2.0| Peribronchiolar, Alveolus, | | | Inflammation, Suppurative | | 1 4.0| __________________________________________________________________________|____________| Nose | | 50 | Foreign Body | | 3 2.0| Fungus | | 5 2.6| Hyperkeratosis, Focal | | 1 3.0| Inflammation, Suppurative | | 13 2.2| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 1 4.0| Necrosis | | 1 4.0| Retina, Degeneration | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Necrosis | | 1 4.0| Nephropathy | | 43 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97 Route: GAVAGE Time: 17:21:38 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Bilateral, Pelvis, Inflammation, | | | Chronic Active | | 1 3.0| Papilla, Mineralization | | 1 2.0| Renal Tubule, Hyperplasia, Focal | | 1 1.0| Renal Tubule, Epithelium, | | | Hyperplasia, Focal | | 18 1.4| Renal Tubule, Epithelium, Hyperplasia| | 1 1.0| Renal Tubule, Epithelium, | | | Hyperplasia, Multifocal | | 4 1.5| __________________________________________________________________________|____________| Urinary Bladder | | 50 | Dilatation | | 2 3.0| Hemorrhage | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 766696-766696/766696 --multipart-boundary--