TR 391 Rat Pathology Tables
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
Facility: Microbiological Associates
Chemical CAS #: 115-96-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3|
DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4|
| 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | 2 2 2 2 2 2 2 |
Cyst | |
Fatty Change, Diffuse | 2 2 |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous, | |
Multifocal | 1 2 2 1 2 |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 |
Centrilobular, Necrosis | 2 3|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 |
Erosion | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 |
Epicardium, Inflammation, Chronic | |
Active | |
Myocardium, Inflammation, Multifocal,| |
Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3|
DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4|
| 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 |
Vacuolization Cytoplasmic, Focal | 1 2 2 1 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + M + M + + + + M +|
Hyperplasia, Focal | |
Bilateral, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + M + + M + M + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 2 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M M + + + + M M + + M + + + + + + + M + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | |
Bronchial, Hyperplasia, Re Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3|
DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4|
| 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M M + + + + + + + +|
Hemorrhage | 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + M M + + + M + + + M M + + + + +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + M + + + + + + + + + + + +|
Galactocele | X X |
Hemorrhage | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 3 3 |
Brain Stem, Gliosis | 1 |
Brain Stem, Hemorrhage | |
Brain Stem, Pigmentation, Hemosiderin| 1 |
Cerebellum, Gliosis | 1 |
Cerebellum, Hemorrhage | 2 |
Cerebellum, Pigmentation, Hemosiderin| 1 |
Cerebrum, Hemorrhage | 2 |
Pons, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 3 2|
Edema | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 4| 3|
DAY ON TEST | 1| 2| 2| 2| 0| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 8| 2| 2| 1| 3| 4|
| 7| 9| 9| 9| 3| 9| 9| 4| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 9| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation | |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3|
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Bilateral, Cataract | 3 |
Retina, Degeneration | 2 3 |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation, Porphyrin | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 |
Cyst | X |
Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 2 2 1 2|
Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9|
| 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + + + + A M + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 2 2 2 2 2 2 2 2 2 |
Cyst | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 |
Necrosis, Multifocal | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + I + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 2 2 2 1 1 2 2 2 2 1 1 1|
Erosion | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Pulp, Inflammation, Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 |
Epicardium, Inflammation, Chronic | |
Active | 4 |
Myocardium, Inflammation, Multifocal,| |
Subacute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9|
| 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + M + + + + +|
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + M + + M + + + +|
Hyperplasia, Focal | 2 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 3 2 |
Cyst | X X X X X |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + M M M + M + + + M M + + + M M +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 4|
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | 2 |
Bronchial, Hyperplasia, Re Cell | 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9|
| 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 4|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + M + M M + + + + + + M + + + M M + M|
Hemorrhage | 3 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + M + + + + + + + + + + + + + + +|
Galactocele | |
Hemorrhage | 2 |
Duct, Ectasia | 2 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Osteopetrosis | 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 2 |
Brain Stem, Gliosis | |
Brain Stem, Hemorrhage | 3 |
Brain Stem, Pigmentation, Hemosiderin| |
Cerebellum, Gliosis | |
Cerebellum, Hemorrhage | |
Cerebellum, Pigmentation, Hemosiderin| |
Cerebrum, Hemorrhage | |
Pons, Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Edema | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 0| 3| 2| 3| 3| 3| 6| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 0| 9|
| 9| 9| 5| 3| 5| 9| 0| 0| 0| 1| 0| 0| 0| 8| 3| 0| 0| 0| 0| 1| 0| 0| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 |
Interstitium, Inflammation | 2 |
Pleura, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 |
Fungus | |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 |
Bilateral, Cataract | 4 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation, Porphyrin | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 1 |
Cyst | |
Nephropathy | 1 1 2 1 1 1 2 2 2 1 1 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 3 1.7|
Basophilic Focus | | 16 2.0|
Cyst | | 1 |
Fatty Change, Diffuse | | 2 2.0|
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 5 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Granulomatous, | | |
Multifocal | | 10 1.3|
Necrosis, Multifocal | | 1 3.0|
Bile Duct, Hyperplasia | | 24 1.9|
Centrilobular, Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis, Focal | | 4 4.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Acinus, Atrophy | | 6 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Degeneration, Cystic | | 34 1.6|
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 11 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Epicardium, Inflammation, Chronic | | |
Active | | 1 4.0|
Myocardium, Inflammation, Multifocal,| | |
Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Hyperplasia, Focal | | 4 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 6 1.7|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 43 |
Hyperplasia, Focal | | 1 2.0|
Bilateral, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Angiectasis | | 4 2.0|
Cyst | | 11 |
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 8 1.5|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 34 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 3 3.3|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 49 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Hydrometra | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Bronchial, Hemorrhage | | 1 2.0|
Bronchial, Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 2 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Hemorrhage | | 1 2.0|
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Hemorrhage | | 2 2.5|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 8 3.4|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 37 |
Hemorrhage | | 1 3.0|
Epithelial Cell, Hyperplasia | | 22 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 46 |
Galactocele | | 2 |
Hemorrhage | | 1 2.0|
Duct, Ectasia | | 6 2.8|
__________________________________________________________________________|____________|
Skin | | 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
Osteopetrosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Brain Stem, Compression | | 5 2.8|
Brain Stem, Gliosis | | 1 1.0|
Brain Stem, Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Brain Stem, Pigmentation, Hemosiderin| | 1 1.0|
Cerebellum, Gliosis | | 1 1.0|
Cerebellum, Hemorrhage | | 1 2.0|
Cerebellum, Pigmentation, Hemosiderin| | 1 1.0|
Cerebrum, Hemorrhage | | 1 2.0|
Pons, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 6 2.8|
Edema | | 1 2.0|
Infiltration Cellular, Histiocyte | | 33 1.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Pigmentation | | 33 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 2 2.0|
Interstitium, Inflammation | | 1 2.0|
Pleura, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 2 1.5|
Fungus | | 1 3.0|
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Cataract | | 2 3.5|
Bilateral, Cataract | | 2 3.5|
Retina, Degeneration | | 3 2.7|
Sclera, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation, Porphyrin | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Calculus Micro Observation Only | | 2 1.5|
Cyst | | 1 |
Nephropathy | | 27 1.3|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1|
| 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 2 2 2 2 2 2 2 |
Congestion | 3 |
Fatty Change, Diffuse | 2 2 2 3 |
Fatty Change, Focal | 1 |
Fatty Change, Multifocal | |
Hematopoietic Cell Proliferation | 1|
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Focal, Necrotizing | |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 1 |
Necrosis, Multifocal | 2 |
Pigmentation, Hemosiderin | |
Regeneration | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
Centrilobular, Necrosis | 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 2 1 2 1 1 1 2 2 1 1 1 1 2 1 1 |
Erosion, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 |
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1|
| 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Necrosis | 4 |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + M + + + + M + + M + + + + M|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + M + M + + + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 3 2 3 2 3 2 |
Cyst | X X X X |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M M + M M M + + M + + + M + + + + + +|
Hyperplasia | |
Duct, Ectasia | 3 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X|
Cervix, Cyst | |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1|
| 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3|
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + M + + + M + + + + M + + + M + + + + + + + + + M|
Hemorrhage | 3 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Duct, Ectasia | 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Ulcer, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 2 |
Pons, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 4 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation | |
Peribronchiolar, Foreign Body | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 1| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 7| 5| 8| 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 3| 3| 9| 1|
| 1| 1| 1| 1| 6| 1| 1| 1| 4| 5| 1| 1| 1| 0| 8| 1| 1| 1| 1| 2| 1| 1| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 1 2 2 2 1 2 2 2 |
Pigmentation | 3 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
Transitional Epithelium, Hyperplasia,| |
Papillary | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6|
| 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 2 2 2 2 2 2 2 2 |
Congestion | |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Fatty Change, Multifocal | 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Focal, Necrotizing | 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 1 1 1 |
Necrosis, Multifocal | 2 |
Pigmentation, Hemosiderin | 2 |
Regeneration | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1|
Erosion, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 |
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6|
| 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + M + + + M + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + M + + + + + M + + M + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 |
Cyst | X X X X X X X X X X|
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + M + + + + + + + + M + + M M M M M + +|
Hyperplasia | 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Cervix, Cyst | X |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + M + + + + M + + + +|
Hemorrhage | 2 3 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 2 |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6|
| 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M + M + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | 3 |
Capsule, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + M + M +|
Hemorrhage | 3 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + + + + + + M + + + + + + + + + +|
Galactocele | X |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 2 3 2 2 3 |
Pons, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 4 2|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Interstitium, Inflammation | 1 |
Peribronchiolar, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Inflammation, Suppurative | 2 |
Ulcer | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 1| 1| 9| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6|
| 1| 1| 1| 4| 4| 1| 1| 1| 1| 4| 1| 1| 6| 7| 8| 1| 1| 1| 1| 4| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
44MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 2 1 1 1 1 2 1 1|
Pigmentation | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 49 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 19 2.0|
Congestion | | 1 3.0|
Fatty Change, Diffuse | | 4 2.3|
Fatty Change, Focal | | 1 1.0|
Fatty Change, Multifocal | | 2 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 3 |
Hepatodiaphragmatic Nodule, Multiple | | 2 |
Inflammation, Focal, Necrotizing | | 1 1.0|
Inflammation, Granulomatous, | | |
Multifocal | | 14 1.0|
Necrosis, Multifocal | | 2 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Regeneration | | 1 2.0|
Bile Duct, Hyperplasia | | 26 2.0|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis, Focal | | 4 4.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Acinus, Atrophy | | 11 1.6|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Degeneration, Cystic | | 36 1.5|
Erosion, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 8 2.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia, Focal | | 2 2.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic, Focal | | 5 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 41 |
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Angiectasis | | 10 2.5|
Cyst | | 14 |
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 35 |
Hyperplasia | | 1 3.0|
Duct, Ectasia | | 4 3.3|
__________________________________________________________________________|____________|
Ovary | | 50 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Decidual Reaction | | 1 |
Cervix, Cyst | | 1 |
Endometrium, Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Mediastinal, Hemorrhage | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 45 |
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 2 2.5|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 45 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | | 49 |
Hematopoietic Cell Proliferation | | 2 3.0|
Capsule, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 42 |
Hemorrhage | | 3 2.7|
Epithelial Cell, Hyperplasia | | 29 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 46 |
Galactocele | | 3 |
Duct, Ectasia | | 5 2.6|
__________________________________________________________________________|____________|
Skin | | 49 |
Ulcer, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Brain Stem, Compression | | 7 2.4|
Pons, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 4.0|
Hemorrhage | | 3 3.3|
Infiltration Cellular, Histiocyte | | 26 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
44MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Granulomatous, | | |
Multifocal | | 3 2.0|
Pigmentation | | 26 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 8 1.9|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation | | 1 1.0|
Peribronchiolar, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Hemorrhage | | 2 2.0|
Inflammation, Suppurative | | 2 2.5|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.5|
Retina, Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 23 1.5|
Pigmentation | | 1 3.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 2 2.0|
Transitional Epithelium, Hyperplasia,| | |
Papillary | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3|
DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9|
| 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + M M + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 3 |
Fatty Change, Diffuse | 3 3 |
Fatty Change, Focal | |
Fatty Change, Multifocal | |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X X X X|
Inflammation, Granulomatous, | |
Multifocal | 1 |
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 |
Centrilobular, Degeneration | 2 |
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 |
Erosion | 2 |
Erosion, Multifocal | 2 |
Ulcer | |
Submucosa, Fibrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 1 |
Endocardium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3|
DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9|
| 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3|
Hyperplasia, Focal | 2 |
Necrosis | 3|
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 2 3 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + M M + I + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 2 |
Cyst | X X X X |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M M M + M + M + + + + M + + + + M + + M + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Suppurative | 2 |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3|
DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9|
| 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 |
Hemorrhage | 4 |
Necrosis | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + M + + + + M + + + M + + + +|
Cyst | X |
Hemorrhage | 2 3 2|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + M + + + + + + + + + + + + + + + + +|
Galactocele | X |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | |
Brain Stem, Gliosis | 2 1 3 3 3 2 2 |
Brain Stem, Hemorrhage | 1 2 1 2 1 |
Brain Stem, Mineralization | 4 1 |
Brain Stem, Necrosis | |
Brain Stem, Pigmentation, Hemosiderin| 1 1 1 2 2 2 2 2 |
Cerebellum, Hemorrhage | 4 |
Cerebellum, Necrosis | |
Cerebrum, Gliosis | 3 2 3 1 2 1 2 |
Cerebrum, Hemorrhage | 1 2 2 1 3 1 1 1 |
Cerebrum, Mineralization | 3 4 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 6| 5| 5| 4| 7| 7| 5| 5| 5| 7| 7| 5| 5| 3|
DAY ON TEST | 3| 0| 3| 0| 9| 3| 3| 1| 8| 8| 3| 1| 9| 4| 7| 3| 0| 7| 3| 3| 3| 3| 3| 1| 9|
| 1| 4| 4| 4| 2| 1| 1| 0| 7| 8| 1| 2| 6| 7| 0| 1| 4| 6| 6| 4| 1| 1| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebrum, Pigmentation, Hemosiderin | 1 2 2 1 1 1 2 1 1 |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 4 1 3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Leukocytosis | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Interstitium, Inflammation | 1 |
Peribronchiolar, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 3 |
Ulcer | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 3 |
Necrosis | |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 2 2 1 |
Nephropathy | 2 1 1 2 2 1 1 1 1 1 2 1 1 |
Pelvis, Inflammation, Chronic | 3 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 1 |
Renal Tubule, Epithelium, Hyperplasia| 1 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5|
| 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 2 2 2 |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 2 |
Fatty Change, Multifocal | 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 |
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 1 2 2 2 3 2 2 2 2 2 |
Centrilobular, Degeneration | |
Centrilobular, Fatty Change | 1 |
Centrilobular, Necrosis | 3|
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Acute | 3 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 2 1 1 1 1 1 3 1 1 1 1 2 2 1 2 1 |
Erosion | |
Erosion, Multifocal | |
Ulcer | 3 |
Submucosa, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 1 1 |
Endocardium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5|
| 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Focal | 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + M + + + + + M + M M M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M M + + + + + + + + + + +|
Angiectasis | 3 2 2 2 2 |
Cyst | X X X X |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + M + + M + M M + + + + M + M + M + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 2 |
Duct, Ectasia | 3 3 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Inflammation, Suppurative | 2 |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5|
| 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hemorrhage | 3 2 |
Hyperplasia, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + M + + M + + + M + + + + + M M M + +|
Cyst | X |
Hemorrhage | 1 1|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Galactocele | X |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 2 |
Brain Stem, Gliosis | 2 1 2 2 2 2 2 2 |
Brain Stem, Hemorrhage | 1 1 1 1 2 1 1 |
Brain Stem, Mineralization | 3 3 2 3 3 |
Brain Stem, Necrosis | 1 |
Brain Stem, Pigmentation, Hemosiderin| 2 1 1 1 2 2 1 2 1 |
Cerebellum, Hemorrhage | 3 |
Cerebellum, Necrosis | 3 |
Cerebrum, Gliosis | 1 3 3 2 3 3 1 1 2 2 1 2 |
Cerebrum, Hemorrhage | 1 1 1 1 1 1 1 1 1 |
Cerebrum, Mineralization | 1 1 1 1 1 2 1 1 1 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 4| 1| 7| 7| 7| 6| 5| 7| 7| 6| 6| 2| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 3| 1| 1| 6| 3| 3| 1| 3| 5| 3| 3| 3| 8| 8| 2| 3| 7| 6| 8| 3| 1| 3| 9| 5|
| 1| 1| 7| 0| 9| 1| 1| 0| 1| 4| 1| 1| 1| 7| 1| 4| 1| 5| 0| 8| 1| 8| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
88 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebrum, Pigmentation, Hemosiderin | 1 2 2 1 2 1 3 1 1 1 1 1 1 |
Meninges, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 4 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Leukocytosis | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation | |
Peribronchiolar, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 4 4 |
Ulcer | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 4 4 |
Necrosis | 4 |
Retina, Degeneration | 4 2 4 |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 1 |
Nephropathy | 1 1 2 1 2 2 1 1 1 3 1 2 1 1 2 1 1 1 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 2 1 1 1 1 1 1 1 |
Renal Tubule, Epithelium, Hyperplasia| 1 1 1 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 9 2.1|
Fatty Change, Diffuse | | 3 2.7|
Fatty Change, Focal | | 2 1.5|
Fatty Change, Multifocal | | 2 1.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | | 6 |
Inflammation, Granulomatous, | | |
Multifocal | | 6 1.0|
Necrosis, Multifocal | | 2 2.0|
Bile Duct, Hyperplasia | | 28 1.9|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Fatty Change | | 2 1.5|
Centrilobular, Necrosis | | 1 3.0|
Periportal, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 7 1.7|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Acute | | 2 2.5|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Degeneration, Cystic | | 36 1.3|
Erosion | | 1 2.0|
Erosion, Multifocal | | 1 2.0|
Ulcer | | 1 3.0|
Submucosa, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 15 1.7|
Endocardium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal | | 4 2.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 5 1.8|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 45 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Angiectasis | | 10 2.2|
Cyst | | 8 |
Pigmentation, Hemosiderin | | 2 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 5 1.6|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 32 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 2.5|
Duct, Ectasia | | 7 2.7|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Hydrometra | | 1 3.0|
Inflammation, Suppurative | | 2 2.0|
Endometrium, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Bronchial, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Hemorrhage | | 3 2.3|
Hyperplasia, Plasma Cell | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 49 |
Hemorrhage | | 1 1.0|
Sinus, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 6 3.5|
Hemorrhage | | 1 4.0|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Thymus | | 39 |
Cyst | | 2 |
Hemorrhage | | 5 1.8|
Epithelial Cell, Hyperplasia | | 20 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 47 |
Galactocele | | 2 |
Duct, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Skin | | 49 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Brain Stem, Compression | | 1 2.0|
Brain Stem, Gliosis | | 15 2.1|
Brain Stem, Hemorrhage | | 12 1.3|
Brain Stem, Mineralization | | 7 2.7|
Brain Stem, Necrosis | | 1 1.0|
Brain Stem, Pigmentation, Hemosiderin| | 17 1.5|
Cerebellum, Hemorrhage | | 2 3.5|
Cerebellum, Necrosis | | 1 3.0|
Cerebrum, Gliosis | | 19 2.0|
Cerebrum, Hemorrhage | | 17 1.2|
Cerebrum, Mineralization | | 15 1.7|
Cerebrum, Pigmentation, Hemosiderin | | 22 1.4|
Meninges, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage | | 7 2.6|
Infiltration Cellular, Histiocyte | | 28 1.0|
Leukocytosis | | 1 2.0|
Pigmentation | | 28 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation | | 1 1.0|
Peribronchiolar, Foreign Body | | 2 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 3 3.7|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 8 |
Cataract | | 4 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
88 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Necrosis | | 1 4.0|
Retina, Degeneration | | 5 3.4|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Calculus Micro Observation Only | | 5 1.6|
Nephropathy | | 32 1.3|
Pelvis, Inflammation, Chronic | | 1 3.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 11 1.1|
Renal Tubule, Epithelium, Hyperplasia| | 4 1.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7|
| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Wall, Foreign Body | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | 2 2 2 2 |
Congestion | 2 |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 2 |
Fatty Change, Multifocal | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 1 1 1 |
Leukocytosis | |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Centrilobular, Fatty Change | 3 1|
Centrilobular, Necrosis | 1 2 |
Periportal, Fatty Change | |
Periportal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Necrosis, Focal | 4 4 4 3|
Fat, Necrosis, Multifocal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Ectopic Tissue | |
Necrosis, Focal | |
Acinus, Atrophy | 2 1 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7|
| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 2 1 2 2 |
Vacuolization Cytoplasmic, Multifocal| |
Bilateral, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + M M M +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + M + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X X |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M M + M M M + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7|
| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hypospermia | 4 4 |
Arteriole, Inflammation, Chronic | 1 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | |
Mediastinal, Hemorrhage | 2 2 2 |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + M + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + M + M I + + + M + + + + + M + + + + + M + + + M|
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + + + M M + M + + M M + + M M + M + +|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 3 |
Brain Stem, Pigmentation, Hemosiderin| 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 9| 6| 1| 2| 2| 2| 0| 4| 2| 2| 2| 2| 7|
| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 3| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 |
Hemorrhage | 2 2|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Focal, Granulomatous | |
Inflammation, Granulomatous, | |
Multifocal | |
Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Bronchiole, Inflammation, Suppurative| |
Interstitium, Inflammation | 1 |
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fungus | 3 3 3 |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 1 2 1 3 2 2 2 2 2 2 2 2 1 2 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 4 |
Wall, Foreign Body | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + I I + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 2 2 2 2 2 2 2 |
Congestion | 3 |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 |
Fatty Change, Multifocal | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 |
Leukocytosis | 2 |
Pigmentation, Hemosiderin | 1 |
Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | 2 |
Periportal, Fatty Change | 1 1 1 1 |
Periportal, Fibrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis, Focal | 4 4 4 4 4 4 4 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Necrosis, Focal | 3 |
Acinus, Atrophy | 2 1 2 1 2 2 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 2 2 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia, Focal | 2 2 |
Hypertrophy | 3 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 2|
Vacuolization Cytoplasmic, Multifocal| 2 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + M + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + M + M + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Hypospermia | 4 3 4 |
Arteriole, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | 3 |
Mediastinal, Hemorrhage | 2 2 2 3 |
Mediastinal, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + M M + + M + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Sinus, Ectasia | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 3 3|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M + M M + + + M M +|
Hemorrhage | 3 3|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + M M + + + + M + M M M + + + M + M M +|
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 2 |
Brain Stem, Pigmentation, Hemosiderin| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 5| 2| 2| 1| 0| 9| 2| 2| 2| 2| 4| 2| 2| 2| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 3| 0| 9| 9| 8| 5| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 |
Inflammation, Focal, Granulomatous | 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 1 2 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
Bronchiole, Inflammation, Suppurative| 2 |
Interstitium, Inflammation | 1 |
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | 2 |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 3 2 1 1 3 3 1 1 2 2 2 1 1 1 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Wall, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 45 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 3 2.0|
Basophilic Focus | | 13 2.0|
Congestion | | 2 2.5|
Fatty Change, Diffuse | | 2 1.5|
Fatty Change, Focal | | 2 1.5|
Fatty Change, Multifocal | | 1 1.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Granulomatous, | | |
Multifocal | | 13 1.0|
Leukocytosis | | 1 2.0|
Pigmentation, Hemosiderin | | 1 1.0|
Bile Duct, Hyperplasia | | 42 1.9|
Centrilobular, Fatty Change | | 3 2.0|
Centrilobular, Necrosis | | 3 1.7|
Periportal, Fatty Change | | 4 1.0|
Periportal, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 13 |
Fat, Necrosis, Focal | | 11 3.9|
Fat, Necrosis, Multifocal | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Ectopic Tissue | | 1 |
Necrosis, Focal | | 1 3.0|
Acinus, Atrophy | | 9 1.7|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Degeneration, Cystic | | 38 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 25 2.0|
Atrium, Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Atrophy | | 1 4.0|
Hyperplasia, Focal | | 4 2.0|
Hypertrophy | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 8 1.5|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bilateral, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 43 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Cyst | | 4 |
Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 42 |
Inflammation, Chronic | | 2 2.0|
Inflammation, Chronic Active | | 4 3.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hyperplasia, Focal | | 7 2.1|
Inflammation, Chronic | | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Granuloma Sperm | | 1 3.0|
Hypospermia | | 5 3.8|
Arteriole, Inflammation, Chronic | | 1 1.0|
Interstitial Cell, Hyperplasia | | 10 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Sinus, Ectasia | | 1 3.0|
Mediastinal, Hemorrhage | | 7 2.1|
Mediastinal, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 44 |
Hemorrhage | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Hemorrhage | | 2 2.0|
Sinus, Ectasia | | 6 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Congestion | | 1 3.0|
Fibrosis | | 4 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 37 |
Hemorrhage | | 3 2.7|
Epithelial Cell, Hyperplasia | | 19 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 29 |
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Cyst Epithelial Inclusion | | 1 |
Fibrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Brain Stem, Compression | | 4 2.8|
Brain Stem, Pigmentation, Hemosiderin| | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 6 2.7|
Hemorrhage | | 3 1.7|
Infiltration Cellular, Histiocyte | | 25 1.1|
Inflammation, Focal, Granulomatous | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Pigmentation | | 26 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 13 1.9|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
Interstitium, Inflammation | | 2 1.0|
Peribronchiolar, Alveolus, | | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Congestion | | 1 3.0|
Fungus | | 4 2.8|
Hemorrhage | | 2 2.5|
Inflammation, Suppurative | | 10 2.1|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 2 4.0|
Retina, Degeneration | | 2 3.5|
Sclera, Metaplasia, Osseous | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 45 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4|
| 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + I I + + + I I A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Erosion | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 2 2 |
Congestion | 2 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 2 |
Fatty Change, Diffuse | 4 |
Fatty Change, Focal | |
Fatty Change, Multifocal | 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 2 |
Mixed Cell Focus | 2 2 |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Centrilobular, Necrosis | |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis, Focal | 3 4 4 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 1 1 1|
Acinus, Hyperplasia, Focal | 2 |
Artery, Inflammation, Chronic | 4 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 2 2 1 1 2 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4|
| 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Atrium, Thrombosis | 2 2 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 |
Hyperplasia, Multifocal | 3 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + M + M + + + + + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X |
Hemorrhage | 2 |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
Hyperplasia, Focal | 3 2 2 3 2 3 2 |
Hyperplasia, Multifocal | |
Inflammation, Chronic Active | 2 3 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4|
| 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granuloma Sperm | 3 |
Hypospermia | 2 4 4 4 4|
Arteriole, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
Mediastinal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + + + + + + + + M + + + + M + M M|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Pigmentation, Hemosiderin | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + I + + + + A + + + + + + M + + + + + + + +|
Hemorrhage | 2 2 2 |
Sinus, Ectasia | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 3 |
Infarct | 4 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + M M + M + M M + + + +|
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M M + + + + M + + M + M + + M + + M M|
Galactocele | |
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Femur, Proliferation, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 0| 4|
| 0| 0| 0| 0| 6| 0| 0| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 |
Cerebrum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 1 2 |
Pigmentation | 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation | 3 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 |
Hyperkeratosis, Focal | |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 4 |
Retina, Degeneration | 3 4 |
Sclera, Metaplasia, Osseous | 3 3 |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation, Porphyrin | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Necrosis | 3 |
Nephropathy | 1 2 2 1 2 3 2 1 2 2 2 3 1 2 2 1 2 1 4 2 2 2 1 |
Renal Tubule, Hyperplasia, Focal | 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Epithelium, Hyperplasia| 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7|
| 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + A + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + A A +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 2 2 |
Congestion | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 |
Fatty Change, Multifocal | 1 1|
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 |
Mixed Cell Focus | 2 |
Pigmentation, Hemosiderin | 1 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2|
Centrilobular, Necrosis | 4 2 |
Periportal, Fatty Change | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 |
Acinus, Hyperplasia, Focal | 2 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + A + + + + +|
Degeneration, Cystic | 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7|
| 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M + + M + + + + M + M + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + I + + + + + + I|
Angiectasis | |
Cyst | |
Hemorrhage | 3 4 |
Pigmentation, Hemosiderin | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | 2 2 2 |
Inflammation, Chronic Active | 2 4 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7|
| 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granuloma Sperm | |
Hypospermia | 4 4 4 |
Arteriole, Inflammation, Chronic | 3 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 2 3 2|
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + M|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 3 2 3 |
Pigmentation, Hemosiderin | 2 |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + + + + + + + M +|
Hemorrhage | 2 1|
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Infarct | |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + + + + + M + M + + + + M +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M M M + + + M + M M M + + + M M + M|
Galactocele | X |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Femur, Proliferation, Focal | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 7| 6| 6| 3| 6| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 0| 4| 3| 3| 3| 8| 7|
| 0| 0| 3| 0| 3| 0| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
44MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 |
Cerebrum, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 2 1 |
Pigmentation | 1 2 1 1 1 1 1 1 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 2 |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Fungus | 3 2 2 |
Hyperkeratosis, Focal | 3 |
Inflammation, Suppurative | 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | A + + |
Cataract | 4 3 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation, Porphyrin | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Necrosis | |
Nephropathy | 2 3 2 2 1 1 3 3 2 2 3 1 2 1 2 2 2 2 2 2 2|
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Epithelium, Hyperplasia| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 43 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
Erosion | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 6 2.0|
Congestion | | 1 2.0|
Degeneration, Cystic | | 2 1.5|
Eosinophilic Focus | | 1 2.0|
Fatty Change, Diffuse | | 1 4.0|
Fatty Change, Focal | | 1 2.0|
Fatty Change, Multifocal | | 3 1.3|
Hematopoietic Cell Proliferation | | 3 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Granulomatous, | | |
Multifocal | | 6 1.2|
Mixed Cell Focus | | 3 2.0|
Pigmentation, Hemosiderin | | 2 1.5|
Bile Duct, Hyperplasia | | 46 2.0|
Centrilobular, Necrosis | | 2 2.7|
Periportal, Fatty Change | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Fat, Necrosis, Focal | | 8 3.9|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Acinus, Atrophy | | 10 1.6|
Acinus, Hyperplasia, Focal | | 2 2.0|
Artery, Inflammation, Chronic | | 4 3.5|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Hyperplasia, Focal | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Degeneration, Cystic | | 33 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 36 2.0|
Atrium, Thrombosis | | 4 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia, Focal | | 4 2.3|
Hyperplasia, Multifocal | | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 47 |
Hyperplasia, Focal | | 4 2.0|
Hyperplasia, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | | 46 |
Angiectasis | | 1 2.0|
Cyst | | 3 |
Hemorrhage | | 3 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 48 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
__________________________________________________________________________|____________|
Preputial Gland | | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 6 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Cytoplasmic Alteration | | 1 3.0|
Hyperplasia, Focal | | 10 2.3|
Hyperplasia, Multifocal | | 3 2.0|
Inflammation, Chronic Active | | 7 2.4|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 48 |
__________________________________________________________________________|____________|
Testes | | 50 |
Granuloma Sperm | | 1 3.0|
Hypospermia | | 8 3.8|
Arteriole, Inflammation, Chronic | | 1 3.0|
Interstitial Cell, Hyperplasia | | 11 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Mediastinal, Hemorrhage | | 6 2.3|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Mediastinal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 42 |
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 5 2.8|
Pigmentation, Hemosiderin | | 1 2.0|
Sinus, Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 43 |
Hemorrhage | | 5 1.8|
Sinus, Ectasia | | 5 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Depletion Lymphoid | | 1 4.0|
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | | 2 3.0|
Infarct | | 1 4.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
Epithelial Cell, Hyperplasia | | 24 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 26 |
Galactocele | | 1 |
Duct, Ectasia | | 3 2.3|
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 3 |
Femur, Proliferation, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Brain Stem, Compression | | 2 3.0|
Cerebrum, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 3 2.7|
Hemorrhage | | 3 1.7|
Infiltration Cellular, Histiocyte | | 18 1.1|
Inflammation, Granulomatous, | | |
Multifocal | | 7 1.4|
Pigmentation | | 19 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 6 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 3 2.0|
Interstitium, Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 2 2.0|
Fungus | | 4 2.3|
Hyperkeratosis, Focal | | 1 3.0|
Inflammation, Suppurative | | 9 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
44MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 4 3.5|
Retina, Degeneration | | 3 3.3|
Sclera, Metaplasia, Osseous | | 3 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation, Porphyrin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 3.0|
Necrosis | | 1 3.0|
Nephropathy | | 44 1.9|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Epithelium, Hyperplasia| | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Infiltration Cellular, Lymphocyte | | 2 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6|
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | 2 |
Ulcer, Multifocal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Congestion | |
Degeneration, Cystic | |
Fatty Change, Diffuse | 1 3 |
Fatty Change, Focal | 2 |
Fatty Change, Multifocal | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 |
Pigmentation, Hemosiderin | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 |
Centrilobular, Necrosis | 3 1 |
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + + |
Thrombosis | |
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 |
Acinus, Hyperplasia, Focal | 2 |
Acinus, Hyperplasia, Multifocal | |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Adventitia, Fibrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6|
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 2 1 1 1 1 2 |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Dilatation | 3 |
Mineralization | |
Aortic Valve, Inflammation, Chronic | |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Subacute | 2 |
Myocardium, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bilateral, Vacuolization Cytoplasmic,| |
Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + M + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
Bilateral, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + M M + M + + + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Angiectasis | 2 |
Cyst | X |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6|
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + M + + + + + M|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 3 3 2 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 2 2 |
Inflammation, Chronic Active | 2 3 2 2 2 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + M|
Giant Cell | |
Hypospermia | 4 |
Arteriole, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 2 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 3 |
Adventitia, Fibrosis | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M +|
Hemorrhage | |
Sinus, Ectasia | 2 4 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal, Re Cell | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + M + + + M + M + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6|
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + M M + + + M + + + + M + M M + + +|
Galactocele | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis, Focal | 3 |
Hemorrhage | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 2 |
Brain Stem, Hemorrhage | |
Cerebrum, Gliosis, Focal | 3 |
Cerebrum, Hemorrhage | 1 |
Cerebrum, Pigmentation, Hemosiderin | 1 |
Pons, Hemorrhage | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 2 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Bronchiole, Inflammation, Suppurative| |
Interstitium, Inflammation | 2 |
Peribronchiolar, Alveolus, | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 6| 7| 7| 3| 3| 3| 8| 5| 9| 5| 4| 2| 6|
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 5| 1| 0| 0| 0| 0| 0| 5| 3| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Fungus | 3 3 |
Hyperkeratosis, Focal | 3 |
Inflammation, Suppurative | 1 3 3 2 2 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Necrosis | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
Nephropathy | 2 2 1 2 2 2 2 3 3 3 2 2 3 2 2 2 2 1 2 2 2 2 |
Bilateral, Pelvis, Inflammation, | |
Chronic Active | 3 |
Papilla, Mineralization | 2 |
Renal Tubule, Hyperplasia, Focal | 1 |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 2 2 1 1 1 |
Renal Tubule, Epithelium, Hyperplasia| 1 |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8|
| 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | |
Ulcer, Multifocal | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + I + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Congestion | 3 |
Degeneration, Cystic | 1 |
Fatty Change, Diffuse | 2 2 |
Fatty Change, Focal | 1 |
Fatty Change, Multifocal | 1 1 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous, | |
Multifocal | 1 1 |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 3 2 2|
Centrilobular, Necrosis | 2 3 3 |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Thrombosis | 4 |
Artery, Inflammation, Chronic | |
Fat, Necrosis, Focal | 4 4 4 4 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 1 2 2 |
Acinus, Hyperplasia, Focal | 2 2 2 |
Acinus, Hyperplasia, Multifocal | 3 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Adventitia, Fibrosis | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8|
| 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Dilatation | 2 |
Mineralization | 3 |
Aortic Valve, Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic | 3 |
Atrium, Thrombosis | 3 4 |
Epicardium, Inflammation, Subacute | |
Myocardium, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| 1 |
Bilateral, Vacuolization Cytoplasmic,| |
Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M M + M + + + + + + + + + + + + + + + + + + I +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M M + M + + + M M M + M M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X |
Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8|
| 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Necrosis, Fibrinoid | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + M M + M + + + + + M|
Hyperplasia | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 1 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | 2 |
Inflammation, Chronic Active | 2 3 4 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Giant Cell | 3 |
Hypospermia | 2 3 |
Arteriole, Inflammation, Chronic | 3 |
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 3 3 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Adventitia, Fibrosis | 3 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | I + + + + + + + + + M + + + M + + + + + + + + +|
Hemorrhage | 3 3 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Focal, Re Cell | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + M + + M + + M M + M + + + + + + + + + + M +|
Hemorrhage | 2|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8|
| 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + M M + + + M M + + M + M + + + + M + +|
Galactocele | X |
Duct, Ectasia | 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + M|
Cyst Epithelial Inclusion | X |
Fibrosis, Focal | |
Hemorrhage | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Cranium, Fibrous Osteodystrophy | 2 |
Femur, Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | 3 3 |
Brain Stem, Hemorrhage | 3 |
Cerebrum, Gliosis, Focal | |
Cerebrum, Hemorrhage | |
Cerebrum, Pigmentation, Hemosiderin | |
Pons, Hemorrhage | 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Focal, Granulomatous | |
Inflammation, Granulomatous, | |
Multifocal | 2 2 1 2 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Bronchiole, Inflammation, Suppurative| 4 |
Interstitium, Inflammation | |
Peribronchiolar, Alveolus, | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 3| 3| 9| 3| 3| 3| 3| 5| 2| 3| 0| 9| 8| 3| 3| 3| 3| 7| 8|
| 1| 1| 1| 4| 3| 1| 1| 1| 0| 2| 1| 1| 1| 4| 8| 1| 0| 6| 7| 0| 1| 1| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
88 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 |
Fungus | 2 2 3 |
Hyperkeratosis, Focal | |
Inflammation, Suppurative | 2 2 3 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Necrosis | 4 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Nephropathy | 3 2 2 2 3 3 1 2 4 4 2 3 4 2 2 2 2 2 2 2 2|
Bilateral, Pelvis, Inflammation, | |
Chronic Active | |
Papilla, Mineralization | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Epithelium, | |
Hyperplasia, Focal | 1 1 1 2 2 2 1 1 2 1 2 1 1|
Renal Tubule, Epithelium, Hyperplasia| |
Renal Tubule, Epithelium, | |
Hyperplasia, Multifocal | 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
Hemorrhage | | 1 2.0|
Ulcer, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 2 2.0|
Congestion | | 1 3.0|
Degeneration, Cystic | | 1 1.0|
Fatty Change, Diffuse | | 4 2.0|
Fatty Change, Focal | | 2 1.5|
Fatty Change, Multifocal | | 2 1.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Granulomatous, | | |
Multifocal | | 5 1.0|
Pigmentation, Hemosiderin | | 1 3.0|
Bile Duct, Hyperplasia | | 46 2.0|
Centrilobular, Necrosis | | 5 2.4|
Periportal, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Thrombosis | | 1 4.0|
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | | 8 4.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 11 1.8|
Acinus, Hyperplasia, Focal | | 4 2.0|
Acinus, Hyperplasia, Multifocal | | 1 3.0|
Artery, Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Adventitia, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 2 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic, Focal | | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Degeneration, Cystic | | 39 1.3|
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 31 2.0|
Dilatation | | 2 2.5|
Mineralization | | 1 3.0|
Aortic Valve, Inflammation, Chronic | | 1 3.0|
Artery, Inflammation, Chronic | | 1 3.0|
Atrium, Thrombosis | | 2 3.5|
Epicardium, Inflammation, Subacute | | 1 2.0|
Myocardium, Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Hyperplasia, Focal | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 2 1.5|
Bilateral, Vacuolization Cytoplasmic,| | |
Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 44 |
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Bilateral, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Angiectasis | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 2 |
Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 6 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 3 1.7|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Necrosis, Fibrinoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
__________________________________________________________________________|____________|
Preputial Gland | | 42 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 8 2.3|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Cytoplasmic Alteration | | 1 3.0|
Hyperplasia, Focal | | 3 2.0|
Hyperplasia, Multifocal | | 4 2.0|
Inflammation, Chronic Active | | 10 2.5|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 49 |
Giant Cell | | 1 3.0|
Hypospermia | | 3 3.0|
Arteriole, Inflammation, Chronic | | 1 3.0|
Interstitial Cell, Hyperplasia | | 6 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hemorrhage | | 9 2.2|
Mediastinal, Pigmentation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemosiderin | | 2 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Hyperplasia, Plasma Cell | | 3 3.0|
Adventitia, Fibrosis | | 1 3.0|
Sinus, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 43 |
Hemorrhage | | 3 2.7|
Sinus, Ectasia | | 5 2.4|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 4 3.0|
Hyperplasia, Focal, Re Cell | | 1 4.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 39 |
Hemorrhage | | 2 2.0|
Epithelial Cell, Hyperplasia | | 18 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 32 |
Galactocele | | 1 |
Duct, Ectasia | | 3 2.7|
__________________________________________________________________________|____________|
Skin | | 48 |
Cyst Epithelial Inclusion | | 1 |
Fibrosis, Focal | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 3 |
Cranium, Fibrous Osteodystrophy | | 1 2.0|
Femur, Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Brain Stem, Compression | | 4 2.8|
Brain Stem, Hemorrhage | | 1 3.0|
Cerebrum, Gliosis, Focal | | 1 3.0|
Cerebrum, Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebrum, Pigmentation, Hemosiderin | | 1 1.0|
Pons, Hemorrhage | | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 6 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 22 1.0|
Inflammation, Focal, Granulomatous | | 2 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 6 1.7|
Pigmentation | | 23 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 8 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Bronchiole, Inflammation, Suppurative| | 1 4.0|
Interstitium, Inflammation | | 1 2.0|
Peribronchiolar, Alveolus, | | |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 3 2.0|
Fungus | | 5 2.6|
Hyperkeratosis, Focal | | 1 3.0|
Inflammation, Suppurative | | 13 2.2|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 4.0|
Necrosis | | 1 4.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Necrosis | | 1 4.0|
Nephropathy | | 43 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05042-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIS (2-CHLOROETHYL) PHOSPHATE Date: 04/29/97
Route: GAVAGE Time: 17:21:38
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
88 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Bilateral, Pelvis, Inflammation, | | |
Chronic Active | | 1 3.0|
Papilla, Mineralization | | 1 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Focal | | 18 1.4|
Renal Tubule, Epithelium, Hyperplasia| | 1 1.0|
Renal Tubule, Epithelium, | | |
Hyperplasia, Multifocal | | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Dilatation | | 2 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
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