TR 391 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05042 TRIS 2-CHLOROETHYL PHOSPHATE TIME: 15:06:05
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60128
CONT: N01CP9565001 CAS: 115-96-8
PATHOLOGIST: G. PARKER
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05042 TRIS 2-CHLOROETHYL PHOSPHATE TIME: 15:06:05
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60128
CONT: N01CP9565001 CAS: 115-96-8
PATHOLOGIST: G. PARKER
TRIS 2-CHLOROETHYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 13 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 350 403 419 463 518 539 549 595 603 611 |
| 641 |
| CENSORED DEATHS |
| 399 408 458 458 458 458 458 458 458 458 |
| 458 478 505 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 44MG/KG LOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 11 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 441 506 540 562 574 587 603 620 622 634 |
| 638 647 660 673 702 714 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 88 MG/KGHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 11 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 469 471 528 550 554 575 584 625 630 630 |
| 632 648 653 661 674 676 680 683 687 690 |
| 695 696 700 710 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
==================================================================================
TRIS 2-CHLOROETHYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.3 94.9 92.8 88.5 82.1 77.7 77.7 |
| | |
| | |
|44MG/KG LOW| 100.0 100.0 100.0 100.0 100.0 98.3 94.2 86.0 73.8 67.6 |
| | |
| | |
|88 | 100.0 100.0 100.0 100.0 100.0 95.9 93.9 85.7 71.4 51.0 |
|MG/KGHIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 44MG/KG LOW 88 |
| MG/KGHIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 77.7% 67.6% 51.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.033 P=0.558 P=0.044 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 517.4 607.7 629.2 |
|NATURAL DEATHS (C) | (29.0) (17.9) (14.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 630.8 647.1 639.4 |
|(STANDARD ERROR) | (16.7) (14.2) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIS 2-CHLOROETHYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 11 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 335 343 403 438 489 582 597 619 633 634 |
| 683 695 702 703 711 717 728 |
| CENSORED DEATHS |
| 161 458 458 458 458 458 459 459 459 459 |
| 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 44MG/KG LOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 13 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 85 310 561 588 598 617 620 652 671 686 |
| 697 704 716 724 |
| CENSORED DEATHS |
| 154 154 154 459 459 459 459 459 459 459 |
| 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 88 MG/KG HIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 29 CENSORED DEATHS 14 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 431 469 470 492 519 534 536 547 555 576 |
| 581 588 592 596 604 610 610 612 617 634 |
| 660 675 687 687 704 704 710 718 724 |
| CENSORED DEATHS |
| 154 261 288 394 459 459 459 459 459 459 |
| 459 459 459 534 |
| |
==================================================================================
TRIS 2-CHLOROETHYL PHOSPHATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 96.6 94.9 93.2 91.1 87.0 80.8 66.3 |
| | |
| | |
|44MG/KG LOW| 98.3 98.3 98.3 96.6 96.6 96.6 96.6 90.1 83.7 70.8 |
| | |
| | |
|88 | 100.0 100.0 100.0 100.0 100.0 93.9 85.4 67.8 54.7 37.2 |
|MG/KG HIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 44MG/KG LOW 88 |
| MG/KG HIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.3% 70.8% 37.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.005 P=0.731N P=0.008 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 588.9 587.8 601.4 |
|NATURAL DEATHS (C) | (32.9) (47.7) (15.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 634.8 622.3 593.3 |
|(STANDARD ERROR) | (18.0) (22.1) (17.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIS 2-CHLOROETHYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
44MG/KG LOW = 2
88 MG/KGHIGH = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 1 2 2
| 33
| 1 1 3 2 3 2
95 + 1 1
| 3 23 2
| 1 1 22
| 1 1 33
90 + 3 232
| 1 1
| 32 2
| 1 3 1 2 23
P 85 +
E | 1 1
R | 112 2
C |
E 80 + 1 321
N |
T | 312 1
| 2 2
S 75 + 33
U | 3 2 2
R |
V | 3 2 2
I 70 + 22
V |
A | 33 2 2
L |
65 +
| 33
|
|
60 +
| 33
|
|
55 +
|
| 3 3
| 3 3
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
TRIS 2-CHLOROETHYL PHOSPHATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
44MG/KG LOW = 2
88 MG/KG HIGH = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 2 11 1 3 3 2
| 1 1 33 3 2 2
| 1 13 3 2 2
90 + 1 3 3 1 1 2
| 1 1
P | 3 3 1 1 2
E | 33 2 2 2
R 80 + 3 3 1 1 2
C | 33 1 11
E | 3 3 2 2
N | 33 1122
T 70 + 33 112 2
| 33 11 1
S |
U | 33
R 60 + 3 3
V | 3 3
I | 3 3
V | 3 3
A 50 +
L | 3 3
| 33
| 33
40 + 33
| 3 3
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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