TR 392 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
CHLORAMINE
NTP Experiment-Test: 05089-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 9 10
Early Deaths
Natural Death 3 3 6
Moribund Sacrifice 13 14 14
Accidently Killed 1 1
Survivors
Terminal Sacrifice 33 32 31
Animals Examined Microscopically 60 10 60 6 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (9) (49) (49)
Cyst 3 (5%) 1 (2%)
Dilatation 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (57) (10) (47) (51)
Edema 2 (4%)
Intestine Large, Rectum (57) (8) (50) (50)
Erosion 1 (2%)
Intestine Small, Duodenum (58) (9) (46) (51)
Erosion 1 (2%)
Intestine Small, Ileum (58) (10) (50) (51)
Artery, Jejunum, Necrosis, Fibrinoid 1 (2%)
Liver (60) (10) (50) (51)
Angiectasis 1 (2%)
Basophilic Focus 2 (3%) 3 (6%) 2 (4%)
Clear Cell Focus 1 (2%) 2 (4%) 4 (8%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 5 (8%) 4 (8%) 2 (4%)
Hemorrhage 2 (3%)
Hyperplasia, Focal 12 (20%) 11 (22%) 11 (22%)
Hyperplasia, Lymphoid 6 (10%) 2 (4%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Acute 1 (10%)
Inflammation, Chronic 2 (3%) 1 (2%)
Inflammation, Subacute 5 (8%) 3 (6%) 9 (18%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Karyomegaly 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (5%) 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Hyperplasia 1 (2%) 1 (2%) 5 (10%)
Kupffer Cell, Pigmentation 2 (3%) 2 (4%)
Lobules, Necrosis 6 (10%) 4 (8%) 3 (6%)
Mesentery (17) (8) (10)
Edema 1 (6%)
Artery, Necrosis, Fibrinoid 1 (6%)
Fat, Inflammation, Suppurative 1 (6%)
Fat, Necrosis 14 (82%) 6 (75%) 7 (70%)
Pancreas (60) (10) (50) (50)
Atrophy 3 (5%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration 2 (3%) 2 (4%) 5 (10%)
Focal Cellular Change 1 (2%)
Hyperplasia, Lymphoid 8 (13%) 9 (18%) 6 (12%)
Inflammation, Subacute 1 (2%)
Salivary Glands (59) (10) (50) (51)
Hyperplasia, Lymphoid 24 (41%) 15 (30%) 11 (22%)
Necrosis 1 (2%)
Acinus, Hyperplasia, Cystic 1 (2%)
Stomach, Forestomach (60) (10) (50) (51)
Cyst 1 (2%)
Diverticulum 1 (2%)
Edema 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 2 (3%) 6 (12%) 1 (2%)
Stomach, Glandular (60) (10) (50) (51)
Cyst 10 (17%) 8 (16%) 13 (25%)
Edema 2 (3%) 1 (2%)
Erosion 1 (2%) 2 (4%)
Inflammation, Subacute 3 (5%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1)
Necrosis, Fibrinoid 1 (50%)
Thrombosis 1 (50%)
Heart (60) (10) (50) (51)
Myocardium, Inflammation, Subacute 1 (2%)
Myocardium, Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50) (51)
Accessory Adrenal Cortical Nodule 11 (18%) 1 (10%) 10 (20%) 18 (35%)
Basophilic Focus 3 (5%)
Clear Cell Focus 1 (2%) 2 (4%)
Cyst 2 (4%)
Hyperplasia, Focal 3 (5%) 4 (8%)
Capsule, Hyperplasia 3 (5%) 3 (6%)
X-Zone, Degeneration, Fatty 2 (4%) 1 (2%)
Zona Reticularis, Proliferation 1 (2%)
Adrenal Gland, Medulla (60) (9) (50) (51)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (60) (10) (50) (50)
Hyperplasia 3 (5%) 8 (16%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Parathyroid Gland (57) (10) (49) (50)
Cyst 1 (2%)
Ectopic Thymus 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (58) (9) (50) (50)
Pars Distalis, Angiectasis 3 (5%) 3 (6%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 9 (16%) 6 (12%) 7 (14%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (60) (10) (49) (51)
Degeneration, Cystic 26 (43%) 26 (53%) 26 (51%)
Hyperplasia, Lymphoid 3 (6%) 3 (6%)
Inflammation, Subacute 2 (3%) 3 (6%) 2 (4%)
Follicle, Cyst 3 (5%) 1 (2%)
Follicular Cell, Hyperplasia 12 (20%) 10 (20%) 17 (33%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Ectasia 1 (100%)
Ovary (56) (10) (46) (46)
Angiectasis 11 (20%) 13 (28%) 15 (33%)
Cyst 13 (23%) 11 (24%) 14 (30%)
Hemorrhage 1 (10%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Artery, Necrosis, Fibrinoid 1 (2%)
Uterus (60) (10) (60) (2) (59)
Angiectasis 5 (8%) 4 (7%) 4 (7%)
Hydrometra 20 (33%) 14 (23%) 19 (32%)
Hyperplasia, Cystic 59 (98%) 59 (98%) 58 (98%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%) 3 (5%)
Inflammation, Suppurative 5 (8%) 2 (3%)
Metaplasia, Squamous 1 (2%) 2 (3%) 1 (2%)
Endometrium, Cyst 2 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50) (51)
Hypercellularity 7 (12%) 6 (12%) 5 (10%)
Lymph Node (60) (10) (50) (51)
Artery, Necrosis, Fibrinoid 1 (2%)
Iliac, Angiectasis 2 (3%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 2 (3%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (56) (10) (49) (49)
Hyperplasia, Lymphoid 5 (9%) 4 (8%) 4 (8%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (9) (50) (47)
Depletion Cellular 1 (2%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 1 (2%)
Hemorrhage 2 (3%) 3 (6%) 4 (9%)
Hyperplasia, Lymphoid 4 (7%) 3 (6%) 2 (4%)
Hyperplasia, Plasma Cell 2 (3%) 1 (2%)
Lymphatic, Dilatation 2 (4%)
Spleen (59) (10) (50) (51)
Angiectasis 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 21 (36%) 19 (38%) 17 (33%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 5 (8%) 4 (8%) 3 (6%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (4%) 1 (2%)
Lymphoid Follicle, Hyperplasia 4 (7%) 7 (14%) 6 (12%)
Red Pulp, Atrophy 1 (2%)
Red Pulp, Hyperplasia 3 (5%) 2 (4%) 2 (4%)
Thymus (58) (10) (47) (49)
Angiectasis 3 (5%) 1 (2%) 1 (2%)
Cyst 9 (16%) 10 (21%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Cellular 3 (5%) 6 (13%) 10 (20%)
Ectopic Parathyroid Gland 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (10) (50) (50)
Hyperplasia, Cystic 3 (6%)
Hyperplasia, Lobular 1 (2%)
Skin (60) (10) (50) (51)
Acanthosis 1 (2%) 2 (4%) 3 (6%)
Exudate 1 (2%)
Inflammation, Chronic 1 (2%) 4 (8%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 2 (3%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10) (50) (51)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 6 (10%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (10) (50) (51)
Compression 1 (2%)
Cyst 2 (3%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Parenchyma, Vacuolization Cytoplasmic,
Diffuse 1 (2%)
Thalamus, Mineralization 48 (81%) 27 (54%) 45 (88%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50) (51)
Congestion 2 (3%) 3 (6%)
Edema 1 (2%)
Hemorrhage 2 (3%) 2 (20%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 10 (17%) 9 (18%) 9 (18%)
Infiltration Cellular, Histiocyte 3 (5%) 3 (6%) 7 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic 1 (2%) 1 (10%)
Leukocytosis 1 (2%)
Thrombosis 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Nose (60) (10) (50) (51)
Exudate 3 (5%) 2 (4%) 5 (10%)
Glands, Hyperplasia, Cystic 5 (8%) 3 (6%) 7 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Chronic 1 (100%)
Harderian Gland (1) (1) (3)
Hyperplasia, Focal 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (53) (4) (57)
Casts Protein 14 (23%) 10 (19%) 10 (18%)
Cyst 1 (2%) 6 (11%)
Glomerulosclerosis 2 (3%) 1 (2%) 3 (5%)
Hemorrhage 1 (2%) 1 (2%)
Hydronephrosis 3 (5%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 27 (45%) 14 (26%) 15 (26%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%) 2 (4%)
Mineralization 25 (42%) 9 (17%) 6 (11%)
Interstitium, Pigmentation 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy 4 (7%) 7 (13%) 4 (7%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Dilatation 5 (8%) 4 (8%) 3 (5%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 41 (68%) 2 (20%) 34 (64%) 4 (100%) 40 (70%)
Transitional Epithelium, Hyperplasia 2 (3%) 1 (2%)
Ureter (1)
Dilatation 1 (100%)
Inflammation, Suppurative 1 (100%)
Urinary Bladder (59) (10) (49) (50)
Dilatation 1 (2%) 1 (2%)
Edema 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 26 (44%) 21 (43%) 18 (36%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mucosa, Hyperplasia 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 6 3 3
Moribund Sacrifice 9 19 5
Survivors
Terminal Sacrifice 35 27 42
Natural Death 1
Animals Examined Microscopically 60 4 60 1 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (48) (59) (9)
Cyst 1 (2%)
Dilatation 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (2%)
Intestine Large, Cecum (50) (50) (59) (10)
Edema 3 (6%) 1 (2%)
Intestine Small, Duodenum (48) (50) (59) (10)
Ulcer 1 (2%)
Liver (50) (50) (60) (10)
Angiectasis 1 (2%)
Basophilic Focus 7 (14%) 2 (4%)
Clear Cell Focus 1 (2%) 4 (8%)
Hematopoietic Cell Proliferation 5 (10%) 2 (3%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Focal 9 (18%) 4 (8%) 9 (15%)
Hyperplasia, Lymphoid 4 (8%) 9 (15%)
Inflammation, Chronic 1 (2%) 3 (5%) 4 (40%)
Inflammation, Subacute 7 (14%) 4 (8%) 4 (7%)
Mixed Cell Focus 1 (2%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 6 (12%)
Kupffer Cell, Hyperplasia 1 (2%) 3 (6%) 2 (3%)
Kupffer Cell, Pigmentation 1 (2%)
Lobules, Necrosis 10 (20%) 8 (16%) 5 (8%)
Mesentery (8) (12) (2)
Accessory Spleen 1 (50%)
Fat, Necrosis 6 (75%) 7 (58%) 1 (50%)
Pancreas (49) (49) (60) (10)
Atrophy 2 (4%) 1 (2%) 2 (3%)
Cyst 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cytoplasmic Alteration 5 (10%) 7 (14%) 1 (2%)
Focal Cellular Change 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 5 (10%) 4 (8%) 2 (3%) 1 (10%)
Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (50) (60) (10)
Hyperplasia, Lymphoid 22 (44%) 9 (18%) 19 (32%)
Stomach, Forestomach (50) (50) (59) (10)
Diverticulum 2 (3%)
Edema 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 2 (4%) 6 (12%)
Stomach, Glandular (50) (50) (59) (10)
Cyst 7 (14%) 9 (18%) 10 (17%)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%) 3 (5%)
Metaplasia, Squamous 2 (4%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Hypertrophy 2 (100%)
Inflammation, Chronic 1 (50%)
Heart (50) (50) (60) (10)
Myocardium, Fibrosis 2 (4%)
Myocardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (60) (10)
Accessory Adrenal Cortical Nodule 9 (18%) 8 (16%) 17 (28%) 1 (10%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%) 1 (2%) 2 (3%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Focal 5 (10%) 5 (10%) 1 (2%)
Capsule, Hyperplasia 1 (2%) 2 (3%)
X-Zone, Degeneration, Fatty 1 (2%)
Adrenal Gland, Medulla (50) (50) (60) (9)
Hyperplasia 2 (4%) 3 (6%)
Islets, Pancreatic (48) (49) (60) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 (2%)
Hyperplasia 6 (13%) 8 (16%) 6 (10%)
Hyperplasia, Lymphoid 1 (2%)
Parathyroid Gland (49) (48) (58) (9)
Cyst 1 (2%) 4 (8%)
Ectopic Thymus 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Pigmentation 1 (2%)
Pituitary Gland (47) (48) (60) (8)
Pars Distalis, Angiectasis 4 (9%) 2 (4%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 7 (15%) 9 (19%) 7 (12%)
Thyroid Gland (50) (50) (59) (10)
Degeneration, Cystic 23 (46%) 25 (50%) 21 (36%)
Ectopic Thymus 1 (2%)
Inflammation, Subacute 3 (6%) 1 (2%) 3 (5%)
Follicle, Cyst 1 (2%) 3 (6%) 3 (5%)
Follicular Cell, Hyperplasia 10 (20%) 8 (16%) 9 (15%)
Follicular Cell, Hyperplasia, Diffuse 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2)
Ectasia 2 (100%)
Ovary (48) (48) (57) (10)
Angiectasis 10 (21%) 10 (21%) 15 (26%)
Cyst 17 (35%) 16 (33%) 20 (35%)
Hemorrhage 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
Uterus (59) (4) (60) (1) (60) (10)
Angiectasis 5 (8%) 7 (12%) 4 (7%)
Granuloma 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 18 (31%) 22 (37%) 14 (23%)
Hyperplasia, Cystic 54 (92%) 56 (93%) 56 (93%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%)
Inflammation, Suppurative 3 (5%) 4 (7%) 4 (7%) 1 (10%)
Metaplasia, Squamous 1 (2%) 3 (5%) 3 (5%)
Endometrium, Cyst 4 (100%) 1 (100%) 3 (30%)
Myometrium, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (60) (10)
Hypercellularity 2 (4%) 9 (18%) 4 (7%)
Lymph Node (50) (50) (60) (10)
Iliac, Hematopoietic Cell Proliferation 1 (2%)
Iliac, Hemorrhage 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Iliac, Lymphatic, Dilatation 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hyperplasia, Lymphoid 2 (3%)
Lymph Node, Mandibular (47) (50) (60) (10)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (48) (48) (56) (10)
Hematopoietic Cell Proliferation 3 (6%)
Hemorrhage 1 (2%) 5 (10%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (50) (49) (60) (10)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 13 (26%) 19 (39%) 18 (30%)
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%)
Lymphoid Follicle, Hyperplasia 5 (10%) 6 (12%) 9 (15%)
Red Pulp, Atrophy 1 (2%)
Red Pulp, Hyperplasia 3 (6%) 2 (4%) 4 (7%)
Thymus (47) (46) (51) (10)
Angiectasis 2 (4%) 5 (11%) 2 (4%)
Cyst 4 (9%) 6 (13%) 5 (10%)
Depletion Cellular 3 (6%) 9 (20%) 2 (4%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (60) (10)
Hyperplasia, Cystic 2 (4%) 4 (8%) 2 (3%)
Hyperplasia, Lobular 1 (2%)
Skin (49) (50) (58) (10)
Acanthosis 2 (4%) 2 (3%)
Inflammation, Chronic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (60) (10)
Hyperostosis 7 (14%) 6 (12%) 7 (12%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (60) (10)
Compression 1 (2%) 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Necrosis 2 (4%)
Thalamus, Mineralization 33 (66%) 44 (88%) 39 (65%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (60) (10)
Congestion 5 (10%) 2 (4%) 2 (3%)
Fibrosis 2 (4%)
Hemorrhage 2 (4%) 2 (4%) 2 (3%)
Hyperplasia, Lymphoid 12 (24%) 15 (30%) 13 (22%)
Infiltration Cellular, Histiocyte 2 (4%) 5 (10%) 9 (15%)
Inflammation, Chronic 1 (2%)
Leukocytosis 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Nose (50) (50) (60) (10)
Exudate 3 (6%) 2 (3%)
Glands, Hyperplasia, Cystic 1 (2%) 6 (12%) 4 (7%)
Trachea (50) (49) (59) (10)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
Cornea, Inflammation, Chronic 1 (100%)
Harderian Gland (1) (4) (6)
Cyst 1 (25%) 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Hyperplasia, Focal 1 (25%) 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (56) (60) (10)
Amyloid Deposition 1 (2%)
Casts Protein 6 (11%) 8 (14%) 7 (12%)
Cyst 1 (2%) 2 (3%)
Glomerulosclerosis 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 2 (3%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 15 (26%) 15 (27%) 23 (38%)
Metaplasia, Osseous 4 (7%) 2 (4%) 1 (2%)
Mineralization 8 (14%) 13 (23%) 13 (22%)
Thrombosis 1 (2%)
Interstitium, Pigmentation 1 (2%) 2 (4%)
Renal Tubule, Atrophy 6 (11%) 7 (13%) 8 (13%)
Renal Tubule, Casts Protein 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Dilatation 6 (11%) 4 (7%)
Renal Tubule, Necrosis 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Regeneration 42 (74%) 38 (68%) 31 (52%) 3 (30%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Urinary Bladder (49) (49) (60) (10)
Angiectasis 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 27 (55%) 23 (47%) 35 (58%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10
Scheduled Sacrifice 10 10
Early Deaths
Moribund Sacrifice 12
Natural Death 3
Survivors
Terminal Sacrifice 35
Animals Examined Microscopically 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (60) (10)
Cyst 1 (2%)
Liver (60) (10)
Angiectasis 1 (2%)
Basophilic Focus 6 (10%)
Clear Cell Focus 4 (7%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 12 (20%)
Hyperplasia, Lymphoid 7 (12%)
Inflammation, Chronic 3 (5%) 2 (20%)
Inflammation, Subacute 5 (8%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%)
Hepatocyte, Cytomegaly 1 (2%)
Hepatocyte, Karyomegaly 2 (3%)
Hepatocyte, Nuclear Alteration 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (5%)
Kupffer Cell, Hyperplasia 3 (5%)
Kupffer Cell, Pigmentation 1 (2%)
Lobules, Necrosis 8 (13%) 1 (10%)
Mesentery (8)
Fat, Necrosis 6 (75%)
Pancreas (60) (10)
Atrophy 3 (5%)
Cytoplasmic Alteration 3 (5%)
Focal Cellular Change 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 1 (10%)
Salivary Glands (60) (10)
Hyperplasia, Lymphoid 20 (33%)
Stomach, Forestomach (60) (10)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Diverticulum 1 (2%)
Erosion 1 (2%)
Inflammation, Suppurative 1 (2%)
Mucosa, Hyperplasia 2 (3%)
Stomach, Glandular (60) (10)
Cyst 5 (8%)
Erosion 2 (3%)
Inflammation, Subacute 2 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Hypertrophy 1 (100%)
Heart (60) (10)
Myocardium, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (9)
Accessory Adrenal Cortical Nodule 13 (22%) 3 (33%)
Cyst 1 (2%)
Hyperplasia, Focal 5 (8%)
Necrosis 1 (2%)
X-Zone, Degeneration, Fatty 1 (2%)
Adrenal Gland, Medulla (60) (9)
Hyperplasia 3 (5%)
Islets, Pancreatic (60) (10)
Hyperplasia 8 (13%) 1 (10%)
Parathyroid Gland (58) (10)
Cyst 1 (2%)
Ectopic Thymus 1 (10%)
Pituitary Gland (60) (9)
Pars Distalis, Angiectasis 2 (3%)
Pars Distalis, Hyperplasia 7 (12%)
Thyroid Gland (60) (10)
Degeneration, Cystic 29 (48%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Subacute 2 (3%)
Follicular Cell, Hyperplasia 14 (23%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2)
Ectasia 2 (100%)
Ovary (56) (9)
Angiectasis 7 (13%)
Cyst 16 (29%) 1 (11%)
Developmental Malformation 1 (11%)
Hemorrhage 1 (11%)
Hyperplasia 2 (4%)
Hyperplasia, Cystic 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (60) (10)
Angiectasis 3 (5%)
Hydrometra 21 (35%)
Hyperplasia, Cystic 58 (97%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 3 (5%)
Metaplasia, Squamous 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10)
Angiectasis 1 (2%)
Hypercellularity 6 (10%) 1 (10%)
Myelofibrosis 1 (2%)
Lymph Node (60) (10)
Iliac, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (58) (10)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (58) (10)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
Lymphatic, Dilatation 1 (2%)
Spleen (60) (10)
Angiectasis 1 (2%)
Congestion 3 (5%)
Hematopoietic Cell Proliferation 22 (37%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
Pigmentation, Hemosiderin 4 (7%)
Lymphoid Follicle, Atrophy 4 (7%)
Lymphoid Follicle, Hyperplasia 5 (8%)
Red Pulp, Hyperplasia 3 (5%)
Thymus (55) (10)
Angiectasis 3 (5%)
Cyst 10 (18%)
Depletion Cellular 4 (7%)
Hyperplasia, Lymphoid 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (10)
Hyperplasia, Cystic 2 (3%)
Hyperplasia, Lobular 1 (10%)
Skin (60) (10)
Acanthosis 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10)
Hyperostosis 7 (12%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10)
Compression 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Thalamus, Mineralization 33 (55%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10)
Congestion 3 (5%)
Hemorrhage 7 (12%) 1 (10%)
Hyperplasia, Lymphoid 13 (22%)
Infiltration Cellular, Histiocyte 7 (12%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 2 (3%)
Nose (60) (10)
Exudate 5 (8%)
Glands, Hyperplasia, Cystic 5 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Cataract 1 (50%)
Retina, Atrophy 1 (50%)
Harderian Gland (8)
Hyperplasia 1 (13%)
Hyperplasia, Focal 3 (38%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10)
Casts Protein 7 (12%)
Cyst 5 (8%)
Glomerulosclerosis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 22 (37%)
Metaplasia, Osseous 3 (5%)
Mineralization 13 (22%)
Interstitium, Pigmentation 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy 10 (17%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Pigmentation 2 (3%)
Renal Tubule, Regeneration 34 (57%) 1 (10%)
Urinary Bladder (60) (10)
Hyperplasia, Lymphoid 20 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 4 3 6
Moribund Sacrifice 12 24 16
Survivors
Terminal Sacrifice 34 23 27
Natural Death 1
Animals Examined Microscopically 60 10 60 60 3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (9) (50) (47)
Cyst 1 (2%)
Dilatation 1 (2%) 1 (2%)
Intestine Large, Colon (59) (9) (50) (49)
Diverticulum 1 (2%)
Intestine Small, Duodenum (59) (10) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Metaplasia, Squamous 1 (2%)
Intestine Small, Ileum (58) (10) (49) (48)
Hyperplasia, Lymphoid 1 (2%)
Liver (60) (10) (51) (50)
Angiectasis 2 (4%)
Basophilic Focus 3 (5%) 4 (8%) 4 (8%)
Clear Cell Focus 11 (18%) 11 (22%) 12 (24%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia, Focal 14 (23%) 21 (41%) 18 (36%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (10%)
Inflammation, Chronic 3 (5%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 2 (3%)
Mixed Cell Focus 1 (2%) 1 (2%) 2 (4%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Cytomegaly 7 (12%)
Hepatocyte, Karyomegaly 2 (3%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 11 (18%) 2 (4%) 4 (8%)
Kupffer Cell, Hyperplasia 4 (7%) 3 (6%) 4 (8%)
Kupffer Cell, Pigmentation 3 (6%)
Lobules, Necrosis 3 (5%) 7 (14%) 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (9) (1) (7) (3)
Accessory Spleen 1 (33%)
Fibrosis 1 (11%)
Mineralization 1 (11%)
Fat, Necrosis 6 (67%) 5 (71%) 1 (33%)
Pancreas (60) (10) (50) (50)
Atrophy 6 (10%) 3 (6%) 4 (8%)
Cytoplasmic Alteration 4 (7%) 1 (2%)
Focal Cellular Change 2 (3%) 1 (2%)
Inflammation, Chronic 1 (2%)
Salivary Glands (60) (10) (50) (50)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 21 (35%) 13 (26%) 13 (26%)
Stomach, Forestomach (60) (10) (48) (50)
Edema 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Subacute 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Stomach, Glandular (60) (10) (48) (50)
Cyst 13 (22%) 11 (23%) 5 (10%)
Erosion 4 (8%)
Inflammation, Subacute 1 (2%) 2 (4%)
Metaplasia, Squamous 1 (2%) 1 (2%)
Mineralization 2 (3%) 5 (10%)
Mucosa, Dysplasia 1 (2%) 1 (2%)
Mucosa, Hyperplasia 2 (4%)
Tooth (17) (11) (7)
Dysplasia 17 (100%) 11 (100%) 7 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Hypertrophy 1 (100%)
Inflammation, Chronic 1 (100%)
Heart (60) (10) (50) (50)
Epicardium, Inflammation, Chronic 2 (3%)
Myocardium, Fibrosis 1 (2%)
Myocardium, Inflammation, Chronic 3 (5%) 1 (2%)
Myocardium, Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50) (50)
Accessory Adrenal Cortical Nodule 3 (5%) 1 (10%) 4 (8%) 7 (14%)
Basophilic Focus 2 (3%) 2 (4%)
Clear Cell Focus 3 (5%) 7 (14%) 6 (12%)
Cyst 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 31 (52%) 24 (48%) 20 (40%)
Hypertrophy, Focal 2 (3%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Capsule, Hyperplasia 11 (18%) 11 (22%) 11 (22%)
Adrenal Gland, Medulla (59) (10) (50) (50)
Hyperplasia 3 (5%)
Islets, Pancreatic (60) (10) (50) (50)
Cyst 1 (2%) 1 (2%)
Hyperplasia 38 (63%) 27 (54%) 26 (52%)
Parathyroid Gland (59) (10) (47) (48)
Cyst 2 (3%) 1 (10%) 2 (4%)
Pituitary Gland (58) (9) (45) (49)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 3 (5%) 3 (7%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (60) (10) (49) (50)
Degeneration, Cystic 12 (20%) 17 (35%) 14 (28%)
Inflammation, Subacute 3 (6%)
Follicle, Cyst 3 (6%) 1 (2%)
Follicle, Inflammation, Suppurative 1 (2%)
Follicular Cell, Hyperplasia 5 (8%) 2 (4%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (8) (8) (7)
Dilatation 8 (100%) 8 (100%) 6 (86%)
Inflammation, Suppurative 1 (13%)
Epididymis (60) (9) (50) (50)
Atypia Cellular 2 (4%)
Granuloma Sperm 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 2 (4%)
Spermatocele 1 (2%)
Preputial Gland (4) (10) (11)
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ectasia 4 (100%) 9 (90%) 9 (82%)
Inflammation, Chronic 2 (20%) 1 (9%)
Prostate (60) (10) (50) (49)
Cyst 1 (2%)
Inflammation, Chronic 2 (3%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (60) (10) (51) (50)
Dilatation 20 (33%) 19 (37%) 22 (44%)
Fibrosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Testes (60) (10) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Seminiferous Tubule, Atrophy 2 (3%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Hypercellularity 3 (5%) 4 (8%) 2 (4%)
Necrosis 1 (2%)
Lymph Node (60) (10) (50) (50)
Bronchial, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (58) (10) (46) (48)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 2 (4%)
Hyperplasia, Plasma Cell 3 (5%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (56) (10) (50) (48)
Depletion Cellular 1 (2%)
Hematopoietic Cell Proliferation 6 (11%) 3 (6%) 6 (13%)
Hemorrhage 24 (43%) 15 (30%) 20 (42%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 6 (11%) 2 (4%) 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Spleen (60) (10) (50) (50)
Angiectasis 2 (4%)
Hematopoietic Cell Proliferation 10 (17%) 13 (26%) 12 (24%)
Pigmentation, Hemosiderin 2 (4%) 1 (2%)
Lymphoid Follicle, Atrophy 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymphoid Follicle, Hyperplasia 4 (7%) 4 (8%) 2 (4%)
Red Pulp, Atrophy 2 (3%)
Red Pulp, Hyperplasia 3 (5%) 2 (4%)
Thymus (56) (9) (41) (43)
Cyst 10 (18%) 5 (12%) 8 (19%)
Depletion Cellular 11 (20%) 9 (22%) 11 (26%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (10) (50) (49)
Acanthosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10) (50) (50)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10) (50) (50)
Cyst 1 (2%)
Hemorrhage 2 (4%)
Hydrocephalus 1 (2%)
Thalamus, Mineralization 48 (80%) 38 (76%) 38 (76%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (53) (50)
Congestion 2 (3%) 1 (2%) 2 (4%)
Hemorrhage 2 (3%) 3 (6%) 3 (6%)
Hyperplasia, Lymphoid 6 (10%) 4 (8%) 3 (6%)
Infiltration Cellular, Histiocyte 16 (27%) 9 (17%) 2 (4%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (12%) 2 (4%) 2 (4%)
Artery, Mineralization 1 (2%)
Nose (60) (10) (50) (50)
Exudate 8 (13%) 5 (10%) 8 (16%)
Glands, Hyperplasia, Cystic 6 (10%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 24
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (60) (60) (3)
Casts Protein 11 (18%) 18 (30%) 10 (17%)
Cyst 28 (47%) 24 (40%) 25 (42%)
Glomerulosclerosis 2 (3%)
Granuloma 1 (2%) 1 (2%)
Hydronephrosis 3 (5%) 3 (5%)
Hyperplasia, Lymphoid 12 (20%) 18 (30%) 10 (17%)
Inflammation, Chronic 4 (7%) 3 (5%) 1 (2%)
Metaplasia, Osseous 2 (3%) 1 (2%) 1 (2%)
Mineralization 57 (95%) 54 (90%) 56 (93%)
Pigmentation, Cholesterol 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy 4 (7%) 17 (28%) 16 (27%)
Renal Tubule, Dilatation 7 (12%) 14 (23%) 15 (25%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 2 (3%)
Renal Tubule, Regeneration 55 (92%) 1 (10%) 58 (97%) 55 (92%) 3 (100%)
Transitional Epithelium, Hyperplasia 1 (2%) 3 (5%)
Urinary Bladder (60) (10) (51) (50)
Dilatation 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 4 (8%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 25
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 9 10
Early Deaths
Moribund Sacrifice 13 13 10
Natural Death 3 2 4
Survivors
Terminal Sacrifice 34 35 37
Animals Examined Microscopically 60 2 60 1 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (48) (58) (9)
Cyst 1 (2%) 1 (2%)
Dilatation 2 (3%)
Intestine Large, Cecum (49) (49) (60) (10)
Hyperplasia, Lymphoid 1 (2%)
Liver (52) (55) (60) (10)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 3 (5%) 5 (8%)
Clear Cell Focus 13 (25%) 16 (29%) 4 (7%)
Eosinophilic Focus 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 12 (23%) 23 (42%) 5 (8%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 2 (4%) 3 (5%) 2 (3%)
Inflammation, Chronic Active 1 (2%) 2 (3%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%) 3 (5%)
Centrilobular, Necrosis 2 (4%) 2 (4%) 1 (2%)
Hepatocyte, Cytomegaly 2 (4%) 2 (4%) 7 (12%)
Hepatocyte, Karyomegaly 2 (4%) 3 (5%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 6 (11%) 11 (18%)
Kupffer Cell, Hyperplasia 2 (4%) 4 (7%)
Kupffer Cell, Pigmentation 2 (4%) 1 (2%) 1 (2%)
Lobules, Necrosis 7 (13%) 4 (7%) 6 (10%)
Mesentery (2) (4) (4)
Hemorrhage 1 (50%)
Fat, Fungus 1 (25%)
Fat, Inflammation, Pyogranulomatous 1 (25%)
Fat, Necrosis 1 (50%) 2 (50%) 4 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 26
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (51) (60) (10)
Atrophy 5 (10%) 4 (8%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration 2 (4%) 2 (3%)
Hyperplasia, Lymphoid 2 (4%)
Inflammation, Chronic 1 (2%)
Acinar Cell, Dysplasia, Focal 1 (2%)
Salivary Glands (50) (50) (60) (10)
Hyperplasia, Lymphoid 15 (30%) 13 (26%) 13 (22%)
Stomach, Forestomach (50) (50) (60) (10)
Inflammation, Suppurative 2 (4%) 1 (2%)
Mucosa, Hyperplasia 2 (4%) 1 (2%) 2 (3%)
Stomach, Glandular (50) (50) (60) (10)
Cyst 8 (16%) 6 (12%) 10 (17%)
Erosion 1 (2%)
Inflammation, Subacute 1 (2%) 3 (6%) 1 (2%) 1 (10%)
Metaplasia, Squamous 1 (2%)
Mineralization 3 (6%) 4 (8%) 6 (10%)
Mucosa, Hyperplasia 1 (2%)
Tooth (5) (6) (3)
Dysplasia 5 (100%) 5 (83%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (60) (10)
Epicardium, Inflammation, Chronic 1 (2%)
Myocardium, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (60) (10)
Accessory Adrenal Cortical Nodule 7 (14%) 6 (12%) 7 (12%)
Atrophy 1 (2%)
Basophilic Focus 1 (2%) 2 (3%)
Clear Cell Focus 3 (6%) 6 (12%) 3 (5%)
Cyst 1 (2%)
Developmental Malformation 1 (2%) 2 (4%)
Hyperplasia, Focal 31 (62%) 26 (52%) 21 (35%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Capsule, Hyperplasia 6 (12%) 4 (8%) 4 (7%)
Adrenal Gland, Medulla (50) (50) (60) (10)
Atrophy 1 (2%)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (50) (60) (10)
Hyperplasia 26 (52%) 29 (58%) 18 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 27
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (46) (45) (55) (10)
Cyst 2 (4%) 3 (5%)
Pituitary Gland (49) (49) (59) (10)
Pars Distalis, Cyst 6 (12%) 7 (14%) 3 (5%)
Pars Distalis, Hyperplasia 2 (4%)
Thyroid Gland (49) (50) (59) (10)
Degeneration, Cystic 15 (31%) 13 (26%) 12 (20%)
Ectopic Thymus 1 (2%) 1 (10%)
Inflammation, Subacute 1 (2%)
Follicle, Cyst 4 (8%) 1 (2%) 3 (5%) 1 (10%)
Follicular Cell, Hyperplasia 6 (12%) 4 (8%) 8 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (5) (6) (2)
Dilatation 5 (100%) 5 (83%) 2 (100%)
Epididymis (50) (50) (60) (10)
Atypia Cellular 1 (2%)
Fibrosis 1 (2%)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Preputial Gland (6) (20) (7)
Ectasia 6 (100%) 18 (90%) 7 (100%)
Inflammation, Chronic 2 (33%) 9 (45%) 1 (14%)
Inflammation, Suppurative 1 (5%)
Prostate (51) (50) (60) (10)
Concretion 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (50) (51) (60) (10)
Dilatation 18 (36%) 22 (43%) 8 (13%)
Hemorrhage 1 (2%)
Inflammation, Chronic 2 (4%) 1 (10%)
Testes (50) (50) (60) (10)
Infarct 1 (2%)
Seminiferous Tubule, Atrophy 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 28
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (60) (10)
Angiectasis 1 (2%)
Hypercellularity 2 (4%) 3 (6%) 1 (2%)
Lymph Node (50) (50) (60) (10)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (50) (48) (56) (10)
Hemorrhage 1 (10%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (50) (50) (59) (10)
Hematopoietic Cell Proliferation 1 (2%) 6 (12%) 3 (5%)
Hemorrhage 12 (24%) 16 (32%) 13 (22%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (51) (51) (60) (10)
Angiectasis 1 (2%)
Congestion 2 (3%)
Hematopoietic Cell Proliferation 15 (29%) 8 (16%) 11 (18%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 2 (4%) 4 (8%) 1 (2%)
Red Pulp, Atrophy 1 (2%) 2 (4%) 1 (2%)
Thymus (46) (46) (56) (10)
Cyst 3 (7%) 4 (9%) 9 (16%)
Depletion Cellular 2 (4%) 5 (11%) 7 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (60) (10)
Acanthosis 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%)
Hair Follicle, Cyst 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 29
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (60) (10)
Thalamus, Mineralization 44 (88%) 43 (86%) 47 (78%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (52) (60) (10)
Congestion 2 (4%) 1 (2%)
Embolus 1 (2%)
Hemorrhage 4 (8%) 3 (6%) 1 (2%) 1 (10%)
Hyperplasia, Lymphoid 2 (4%) 5 (10%) 3 (5%)
Infiltration Cellular, Histiocyte 9 (18%) 6 (12%) 8 (13%)
Inflammation, Chronic 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (5%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Nose (50) (50) (60) (10)
Exudate 1 (2%) 2 (4%) 4 (7%)
Foreign Body 1 (2%)
Glands, Hyperplasia, Cystic 1 (2%) 2 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (2) (60) (1) (60) (10)
Casts Protein 14 (23%) 12 (20%) 12 (20%)
Cyst 24 (40%) 23 (38%) 18 (30%)
Glomerulosclerosis 4 (7%)
Granuloma 2 (3%) 3 (5%)
Hydronephrosis 1 (2%) 5 (8%)
Hyperplasia, Lymphoid 18 (30%) 15 (25%) 12 (20%)
Inflammation, Chronic 4 (7%) 5 (8%) 3 (5%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (3%) 1 (2%)
Mineralization 54 (90%) 54 (90%) 56 (93%)
Renal Tubule, Atrophy 8 (13%) 11 (18%) 13 (22%)
Renal Tubule, Degeneration, Focal 1 (2%)
Renal Tubule, Dilatation 25 (42%) 14 (23%) 28 (47%)
Renal Tubule, Hyperplasia, Focal 2 (3%) 1 (2%)
Renal Tubule, Necrosis 2 (3%) 2 (3%)
Renal Tubule, Regeneration 56 (93%) 2 (100%) 59 (98%) 1 (100%) 57 (95%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 30
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (60) (10)
Dilatation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 2 (4%) 5 (8%)
Inflammation, Chronic 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 31
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10
Scheduled Sacrifice 9 10
Early Deaths
Natural Death 8
Moribund Sacrifice 10
Accidently Killed 1
Survivors
Terminal Sacrifice 32
Animals Examined Microscopically 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (56) (9)
Dilatation 2 (4%)
Intestine Small, Ileum (58) (9)
Hyperplasia, Lymphoid 1 (2%)
Liver (60) (10)
Basophilic Focus 4 (7%)
Clear Cell Focus 8 (13%)
Eosinophilic Focus 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 13 (22%)
Inflammation, Chronic 2 (3%) 1 (10%)
Inflammation, Chronic Active 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Cytomegaly 2 (3%)
Hepatocyte, Karyomegaly 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 6 (10%) 1 (10%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 3 (5%)
Lobules, Necrosis 5 (8%)
Mesentery (3) (1)
Inflammation, Chronic 1 (100%)
Fat, Necrosis 2 (67%)
Pancreas (60) (10)
Atrophy 4 (7%)
Cytoplasmic Alteration 2 (3%)
Focal Cellular Change 1 (2%)
Inflammation, Chronic 1 (10%)
Salivary Glands (60) (10)
Hyperplasia, Lymphoid 19 (32%)
Stomach, Forestomach (59) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 32
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Diverticulum 2 (3%)
Edema 1 (2%)
Stomach, Glandular (59) (10)
Cyst 8 (14%) 1 (10%)
Edema 1 (2%)
Inflammation, Subacute 4 (7%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Tooth (7)
Dysplasia 6 (86%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (10)
Epicardium, Inflammation, Chronic 1 (2%)
Myocardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (9)
Accessory Adrenal Cortical Nodule 5 (8%)
Clear Cell Focus 9 (15%)
Hyperplasia, Focal 31 (52%)
Capsule, Hyperplasia 10 (17%)
Capsule, Hyperplasia, Focal 1 (2%)
Adrenal Gland, Medulla (60) (9)
Developmental Malformation 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (60) (10)
Hyperplasia 24 (40%)
Parathyroid Gland (58) (9)
Cyst 2 (3%)
Pituitary Gland (58) (10)
Pars Distalis, Cyst 2 (3%)
Pars Distalis, Hyperplasia 5 (9%)
Thyroid Gland (60) (10)
Degeneration, Cystic 16 (27%)
Follicle, Cyst 4 (7%)
Follicular Cell, Hyperplasia 3 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 33
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4)
Dilatation 4 (100%)
Epididymis (60) (9)
Atypia Cellular 1 (2%)
Inflammation, Chronic 2 (3%)
Preputial Gland (7)
Ectasia 6 (86%)
Inflammation, Chronic 3 (43%)
Seminal Vesicle (60) (10)
Dilatation 14 (23%)
Fibrosis 1 (2%)
Testes (60) (10)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10)
Angiectasis 1 (2%)
Hypercellularity 4 (7%)
Lymph Node (60) (10)
Mediastinal, Hemorrhage 1 (2%)
Lymph Node, Mesenteric (59) (8)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 17 (29%)
Hyperplasia, Lymphoid 4 (7%)
Spleen (60) (10)
Angiectasis 2 (3%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 11 (18%)
Red Pulp, Atrophy 1 (2%)
Red Pulp, Hyperplasia 1 (2%)
Thymus (58) (10)
Cyst 10 (17%)
Depletion Cellular 8 (14%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 34
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (10)
Fat, Necrosis 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10)
Metaplasia, Osseous 1 (2%)
Thalamus, Mineralization 48 (80%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10)
Congestion 3 (5%)
Hemorrhage 2 (3%) 1 (10%)
Hyperplasia, Lymphoid 2 (3%)
Infiltration Cellular, Histiocyte 7 (12%)
Inflammation, Chronic 1 (2%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%)
Nose (60) (10)
Exudate 1 (2%)
Glands, Hyperplasia, Cystic 4 (7%)
Trachea (60) (10)
Inflammation, Suppurative 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10)
Casts Protein 11 (18%)
Cyst 26 (43%)
Glomerulosclerosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 35
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Granuloma 4 (7%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 18 (30%)
Inflammation, Chronic 2 (3%)
Metaplasia, Osseous 1 (2%)
Mineralization 48 (80%)
Renal Tubule, Atrophy 7 (12%)
Renal Tubule, Dilatation 29 (48%)
Renal Tubule, Hyperplasia, Focal 2 (3%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 53 (88%)
Renal Tubule, Vacuolization Cytoplasmic 1 (10%)
Urinary Bladder (60) (10)
Dilatation 3 (5%)
Hyperplasia, Lymphoid 5 (8%)
Inflammation, Chronic 2 (3%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 36
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