TR 392 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CHLORAMINE
NTP Experiment-Test: 05089-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 9 10
Early Deaths
Natural Death 3 3 6
Moribund Sacrifice 13 14 14
Accidently Killed 1 1
Survivors
Terminal Sacrifice 33 32 31
Animals Examined Microscopically 60 10 60 6 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (9) (49) (49)
Intestine Small, Duodenum (58) (9) (46) (51)
Fibrous Histiocytoma 1 (2%)
Intestine Small, Ileum (58) (10) (50) (51)
Intestine Small, Jejunum (58) (10) (49) (51)
Liver (60) (10) (50) (51)
Chemodectoma Malignant, Metastatic, Thyroid
Gland 1 (2%)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 6 (10%) 8 (16%) 6 (12%)
Hepatocellular Carcinoma, Multiple, Two 3 (6%) 1 (2%)
Hepatocellular Adenoma 14 (23%) 10 (20%) 11 (22%)
Hepatocellular Adenoma, Multiple, Two 3 (5%) 1 (2%) 6 (12%)
Hepatocellular Adenoma, Multiple, Three 1 (2%) 1 (2%)
Hepatocellular Adenoma, Multiple, Four 1 (2%) 2 (4%) 1 (2%)
Hepatocellular Adenoma, Multiple, Five 1 (2%)
Hepatocellular Adenoma, Multiple, Greater
Than Five 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (17) (8) (10)
Chemodectoma Malignant 1 (6%)
Hemangiosarcoma 1 (6%)
Histiocytic Sarcoma 1 (10%)
Pancreas (60) (10) (50) (50)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Salivary Glands (59) (10) (50) (51)
Stomach, Forestomach (60) (10) (50) (51)
Hemangioma 1 (2%)
Page 2
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Leiomyoma 1 (2%)
Stomach, Glandular (60) (10) (50) (51)
Carcinoid Tumor Malignant 1 (2%)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1)
Heart (60) (10) (50) (51)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50) (51)
Histiocytic Sarcoma 1 (2%)
Islets, Pancreatic (60) (10) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (58) (9) (50) (50)
Pars Distalis, Adenoma 5 (9%) 11 (22%) 8 (16%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (10) (49) (51)
Chemodectoma Malignant 1 (2%)
Follicular Cell, Adenoma 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (56) (10) (46) (46)
Adenoma 2 (4%)
Cystadenoma 1 (2%) 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Hemangioma 1 (2%)
Teratoma Benign 1 (2%)
Uterus (60) (10) (60) (2) (59)
Carcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 3 (5%)
Sarcoma 1 (2%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50) (51)
Fibrous Histiocytoma 1 (2%)
Lymph Node (60) (10) (50) (51)
Axillary, Fibrosarcoma, Metastatic, Skin 1 (2%)
Renal, Fibrous Histiocytoma 1 (2%)
Lymph Node, Mandibular (56) (10) (49) (49)
Lymph Node, Mesenteric (59) (9) (50) (47)
Fibrous Histiocytoma 1 (2%)
Renal, Iliac, Mediastinal, Mandibular,
Fibrous Histiocytoma 1 (2%)
Spleen (59) (10) (50) (51)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (58) (10) (47) (49)
Fibrous Histiocytoma 1 (2%)
Thymoma Benign 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (10) (50) (51)
Fibrosarcoma 1 (2%)
Mast Cell Tumor Benign 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10) (50) (51)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (3)
Fibrosarcoma, Metastatic, Skin 1 (50%) 1 (33%)
Histiocytic Sarcoma 1 (33%)
Osteosarcoma, Metastatic, Bone 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50) (51)
Alveolar/Bronchiolar Adenoma 4 (7%) 3 (6%) 5 (10%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 6 (12%)
Chemodectoma Malignant, Metastatic, Thyroid
Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1) (3)
Adenoma 1 (100%) 1 (100%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (53) (4) (57)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (59) (10) (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10) *(60) *(6) *(60)
Histiocytic Sarcoma 2 (3%)
Leukemia Erythrocytic 1 (2%)
Leukemia Granulocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%) 3 (5%)
Lymphoma Malignant Mixed 7 (12%) 5 (8%) 10 (17%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 40 43
Total Primary Neoplasms 76 69 72
Total Animals with Benign Neoplasms 29 28 27
Total Benign Neoplasms 43 36 36
Total Animals with Malignant Neoplasms 23 21 30
Total Malignant Neoplasms 33 33 36
Total Animals with Metastatic Neoplasms 3 3 2
Total Metastatic Neoplasm 5 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 6 3 3
Moribund Sacrifice 9 19 5
Survivors
Terminal Sacrifice 35 27 42
Natural Death 1
Animals Examined Microscopically 60 4 60 1 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (48) (59) (9)
Intestine Large, Cecum (50) (50) (59) (10)
Intestine Small, Ileum (49) (49) (57) (10)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Jejunum (49) (49) (58) (10)
Liver (50) (50) (60) (10)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 4 (8%) 6 (12%) 3 (5%)
Hepatocellular Carcinoma, Multiple, Two 2 (4%)
Hepatocellular Carcinoma, Multiple, Four 1 (2%)
Hepatocellular Adenoma 18 (36%) 7 (14%) 11 (18%)
Hepatocellular Adenoma, Multiple, Two 2 (4%) 5 (10%) 2 (3%)
Hepatocellular Adenoma, Multiple, Three 1 (2%) 4 (8%)
Hepatocellular Adenoma, Multiple, Four 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Mesentery (8) (12) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (8%)
Fibrous Histiocytoma 1 (8%)
Pancreas (49) (49) (60) (10)
Salivary Glands (50) (50) (60) (10)
Stomach, Glandular (50) (50) (59) (10)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (60) (10)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (60) (10)
Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50) (60) (9)
Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (48) (49) (60) (10)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (47) (48) (60) (8)
Pars Distalis, Adenoma 4 (9%) 4 (8%) 2 (3%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (59) (10)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (48) (57) (10)
Adenoma 1 (2%)
Cystadenoma 1 (2%) 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Uterus (59) (4) (60) (1) (60) (10)
Carcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 2 (3%)
Polyp Stromal 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (60) (10)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (50) (60) (10)
Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lymph Node, Mandibular (47) (50) (60) (10)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (48) (48) (56) (10)
Spleen (50) (49) (60) (10)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (47) (46) (51) (10)
Fibrous Histiocytoma 1 (2%)
Thymoma Benign 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (60) (10)
Skin (49) (50) (58) (10)
Subcutaneous Tissue, Fibrosarcoma 3 (6%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (60) (10)
Fibrous Histiocytoma 1 (2%)
Osteosarcoma 2 (4%)
Skeletal Muscle (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (60) (10)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (60) (10)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (3%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 5 (10%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%) 1 (2%)
Nose (50) (50) (60) (10)
Glands, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (4) (6)
Adenoma 1 (25%) 4 (67%)
Carcinoma 1 (100%) 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (56) (60) (10)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (49) (49) (60) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(4) *(60) *(1) *(60) *(10)
Histiocytic Sarcoma 1 (2%) 1 (2%) 2 (3%)
Leukemia Erythrocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 3 (5%)
Lymphoma Malignant Mixed 4 (7%) 7 (12%) 11 (18%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 37 32
Total Primary Neoplasms 57 69 59
Total Animals with Benign Neoplasms 28 23 22
Total Benign Neoplasms 37 29 30
Total Animals with Malignant Neoplasms 16 25 21
Total Malignant Neoplasms 20 40 29
Total Animals with Metastatic Neoplasms 1 4 2
Total Metastatic Neoplasm 1 12 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10
Scheduled Sacrifice 10 10
Early Deaths
Moribund Sacrifice 12
Natural Death 3
Survivors
Terminal Sacrifice 35
Animals Examined Microscopically 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (60) (10)
Intestine Small, Jejunum (60) (10)
Hemangioma 1 (2%)
Liver (60) (10)
Hepatocellular Carcinoma 5 (8%)
Hepatocellular Adenoma 18 (30%)
Hepatocellular Adenoma, Multiple, Two 4 (7%)
Hepatocellular Adenoma, Multiple, Greater
Than Five 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (8)
Pancreas (60) (10)
Salivary Glands (60) (10)
Stomach, Forestomach (60) (10)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (9)
Adrenal Gland, Medulla (60) (9)
Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (60) (10)
Adenoma 1 (2%)
Page 12
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (60) (9)
Pars Distalis, Adenoma 6 (10%)
Thyroid Gland (60) (10)
Follicular Cell, Adenoma 2 (3%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (56) (9)
Cystadenocarcinoma 1 (2%)
Uterus (60) (10)
Deciduoma Benign 1 (10%)
Polyp Stromal 4 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (60) (10)
Mediastinal, Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node, Mandibular (58) (10)
Lymph Node, Mesenteric (58) (10)
Spleen (60) (10)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (55) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (10)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (10)
Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10)
Alveolar/Bronchiolar Adenoma 3 (5%)
Alveolar/Bronchiolar Carcinoma 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (3%)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (8)
Adenoma 4 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10)
Osteosarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (60) (10)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%)
Lymphoma Malignant Mixed 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 1
Total Primary Neoplasms 67 1
Total Animals with Benign Neoplasms 36 1
Total Benign Neoplasms 46 1
Total Animals with Malignant Neoplasms 19
Total Malignant Neoplasms 21
Total Animals with Metastatic Neoplasms 3
Total Metastatic Neoplasm 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 4 3 6
Moribund Sacrifice 12 24 16
Survivors
Terminal Sacrifice 34 23 27
Natural Death 1
Animals Examined Microscopically 60 10 60 60 3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (9) (50) (47)
Papilloma 1 (2%)
Intestine Small, Ileum (58) (10) (49) (48)
Carcinoma 1 (2%) 1 (2%)
Intestine Small, Jejunum (59) (10) (50) (50)
Carcinoma 2 (4%) 1 (2%)
Hemangiosarcoma 1 (2%)
Liver (60) (10) (51) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%)
Hemangiosarcoma, Metastatic 1 (2%)
Hepatoblastoma 1 (2%) 2 (4%)
Hepatocellular Carcinoma 11 (18%) 14 (27%) 10 (20%)
Hepatocellular Carcinoma, Multiple, Two 2 (3%) 2 (4%) 3 (6%)
Hepatocellular Carcinoma, Multiple, Three 1 (2%)
Hepatocellular Adenoma 9 (15%) 15 (29%) 15 (30%)
Hepatocellular Adenoma, Multiple, Two 12 (20%) 10 (20%) 10 (20%)
Hepatocellular Adenoma, Multiple, Three 9 (15%) 7 (14%) 2 (4%)
Hepatocellular Adenoma, Multiple, Four 2 (3%) 2 (4%) 1 (2%)
Hepatocellular Adenoma, Multiple, Five 1 (2%)
Hepatocellular Adenoma, Multiple, Greater
Than Five 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Mesentery (9) (1) (7) (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (14%)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (11%)
Hemangioma 1 (14%)
Page 16
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Hepatoblastoma, Metastatic, Liver 1 (11%)
Salivary Glands (60) (10) (50) (50)
Sarcoma 1 (2%)
Stomach, Forestomach (60) (10) (48) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Squamous Cell Papilloma 2 (3%) 1 (2%)
Stomach, Glandular (60) (10) (48) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (10) (50) (50)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Capsule, Adenoma 5 (8%) 4 (8%) 4 (8%)
Adrenal Gland, Medulla (59) (10) (50) (50)
Neuroblastoma Benign 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (60) (10) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Thyroid Gland (60) (10) (49) (50)
Follicular Cell, Adenoma 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (9) (50) (50)
Testes (60) (10) (50) (50)
Hemangioma 1 (2%)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 17
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (60) (10) (50) (50)
Inguinal, Renal, Popliteal, Sarcoma 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Hepatoblastoma, Metastatic,
Liver 1 (2%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%) 1 (2%)
Lymph Node, Mandibular (58) (10) (46) (48)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (56) (10) (50) (48)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (60) (10) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 3 (5%) 2 (4%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (56) (9) (41) (43)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (10) (50) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3)
Fibrosarcoma 1 (33%)
Hepatoblastoma, Metastatic, Liver 1 (33%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 18
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (53) (50)
Alveolar/Bronchiolar Adenoma 16 (27%) 10 (19%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 2 (3%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 9 (15%) 7 (13%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple, Two 2 (4%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (5%) 3 (6%) 2 (4%)
Sarcoma 1 (2%)
Mediastinum, Hemangioma 1 (2%) 1 (2%)
Nose (60) (10) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (1) (5)
Adenoma 3 (100%) 1 (100%) 3 (60%)
Carcinoma 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (60) (60) (3)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Sarcoma 1 (2%)
Urinary Bladder (60) (10) (51) (50)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10) *(60) *(60) *(3)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%)
Lymphoma Malignant Mixed 3 (5%) 3 (5%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE VEHICLE 0.00500% 0.00500% 0.00700% 0.00700%
CONTROL 3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 52 45
Total Primary Neoplasms 105 99 82
Total Animals with Benign Neoplasms 45 41 35
Total Benign Neoplasms 67 61 51
Total Animals with Malignant Neoplasms 25 29 26
Total Malignant Neoplasms 38 38 31
Total Animals with Metastatic Neoplasms 4 4 5
Total Metastatic Neoplasm 14 6 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 20
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10 60 10 60 10
Scheduled Sacrifice 10 10 10 10 9 10
Early Deaths
Moribund Sacrifice 13 13 10
Natural Death 3 2 4
Survivors
Terminal Sacrifice 34 35 37
Animals Examined Microscopically 60 2 60 1 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (48) (49) (58) (10)
Intestine Small, Jejunum (50) (50) (57) (10)
Carcinoma 3 (6%) 2 (4%)
Liver (52) (55) (60) (10)
Hemangiosarcoma 4 (8%) 2 (4%) 2 (3%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 15 (29%) 14 (25%) 10 (17%)
Hepatocellular Carcinoma, Multiple, Two 1 (2%) 2 (4%) 1 (2%)
Hepatocellular Adenoma 14 (27%) 11 (20%) 13 (22%)
Hepatocellular Adenoma, Multiple, Two 1 (2%) 11 (20%) 6 (10%)
Hepatocellular Adenoma, Multiple, Three 5 (10%) 4 (7%) 1 (2%)
Hepatocellular Adenoma, Multiple, Four 1 (2%) 2 (4%) 1 (2%)
Hepatocellular Adenoma, Multiple, Five 1 (2%)
Hepatocellular Adenoma, Multiple, Greater
Than Five 1 (2%)
Mesentery (2) (4) (4)
Hemangiosarcoma 1 (25%)
Stomach, Forestomach (50) (50) (60) (10)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (60) (10)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 21
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (60) (10)
Adenoma 1 (2%)
Capsule, Adenoma 4 (8%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (60) (10)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (60) (10)
Adenoma 1 (2%)
Thyroid Gland (49) (50) (59) (10)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (60) (10)
Prostate (51) (50) (60) (10)
Testes (50) (50) (60) (10)
Interstitial Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (60) (10)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (50) (60) (10)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%)
Lymph Node, Mesenteric (50) (50) (59) (10)
Spleen (51) (51) (60) (10)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 22
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (60) (10)
Neoplasm NOS 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (52) (60) (10)
Alveolar/Bronchiolar Adenoma 10 (20%) 16 (31%) 6 (10%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 7 (14%) 5 (10%) 3 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple,
Three 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (4) (6)
Adenoma 1 (100%) 4 (100%) 5 (83%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (2) (60) (1) (60) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Renal Tubule, Adenoma 2 (3%)
Urinary Bladder (50) (50) (60) (10)
Page 23
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(2) *(60) *(1) *(60) *(10)
Lymphoma Malignant Mixed 3 (5%) 2 (3%) 2 (3%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 24
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0100% 0.0100% 0.0140% 0.0140% 0.0200% 0.0200%
3 SSAC 3 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 50 41
Total Primary Neoplasms 82 87 62
Total Animals with Benign Neoplasms 32 40 31
Total Benign Neoplasms 45 55 39
Total Animals with Malignant Neoplasms 29 24 19
Total Malignant Neoplasms 36 32 23
Total Animals with Metastatic Neoplasms 3 2 2
Total Metastatic Neoplasm 4 2 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 25
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10
Scheduled Sacrifice 9 10
Early Deaths
Natural Death 8
Moribund Sacrifice 10
Accidently Killed 1
Survivors
Terminal Sacrifice 32
Animals Examined Microscopically 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (58) (9)
Carcinoma 1 (2%)
Intestine Small, Jejunum (58) (10)
Carcinoma 2 (3%)
Liver (60) (10)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 11 (18%)
Hepatocellular Carcinoma, Multiple, Two 2 (3%)
Hepatocellular Carcinoma, Multiple, Three 2 (3%)
Hepatocellular Adenoma 18 (30%)
Hepatocellular Adenoma, Multiple, Two 5 (8%)
Hepatocellular Adenoma, Multiple, Three 4 (7%)
Hepatocellular Adenoma, Multiple, Five 1 (2%)
Mesentery (3) (1)
Pancreas (60) (10)
Salivary Glands (60) (10)
Stomach, Forestomach (59) (10)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (59) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Hemangioma 1 (100%)
Heart (60) (10)
____________________________________________________________________________________________________________________________________
Page 26
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (9)
Adenoma 1 (2%)
Capsule, Adenoma 5 (8%)
Adrenal Gland, Medulla (60) (9)
Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (60) (10)
Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (7)
Squamous Cell Carcinoma 1 (14%)
Prostate (60) (10)
Testes (60) (10)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10)
Lymph Node (60) (10)
Mediastinal, Squamous Cell Carcinoma,
Metastatic, Preputial Gland 1 (2%)
Lymph Node, Mandibular (57) (10)
Lymph Node, Mesenteric (59) (8)
Spleen (60) (10)
Hemangioma 1 (2%)
Thymus (58) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (4)
Carcinoma 1 (25%)
____________________________________________________________________________________________________________________________________
Page 27
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Squamous Cell Carcinoma, Metastatic,
Preputial Gland 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10)
Alveolar/Bronchiolar Adenoma 15 (25%)
Alveolar/Bronchiolar Carcinoma 7 (12%)
Alveolar/Bronchiolar Carcinoma, Multiple,
Three 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Preputial Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(10)
Lymphoma Malignant Mixed 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 28
NTP Experiment-Test: 05089-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 09/11/94
Route: DOSED WATER Time: 22:29:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0275% 0.0275%
3 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 52
Total Primary Neoplasms 90
Total Animals with Benign Neoplasms 38
Total Benign Neoplasms 53
Total Animals with Malignant Neoplasms 31
Total Malignant Neoplasms 37
Total Animals with Metastatic Neoplasms 3
Total Metastatic Neoplasm 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 29
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