TR 392 Mouse Pathology Tables
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|
| 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + I + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Jejunum, Necrosis, Fibrinoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 4 |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | |
Hyperplasia, Focal | 2 3 2 3 1 2 4 |
Hyperplasia, Lymphoid | 1 1 1 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | |
Inflammation, Subacute | 3 1 |
Mineralization | |
Mixed Cell Focus | X |
Artery, Necrosis, Fibrinoid | 4 |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Edema | |
Artery, Necrosis, Fibrinoid | 4 |
Fat, Inflammation, Suppurative | |
Fat, Necrosis | 4 2 3 4 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
Cytoplasmic Alteration | 2 3 |
Focal Cellular Change | X |
Hyperplasia, Lymphoid | 1 2 2 |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|
| 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 1 1 3 |
Acinus, Hyperplasia, Cystic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Diverticulum | |
Edema | 2 |
Inflammation, Suppurative | 2 |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | 2 2 |
Erosion | 2 |
Inflammation, Subacute | 2 |
Metaplasia, Squamous | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Necrosis, Fibrinoid | 4 |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Subacute | 3 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Basophilic Focus | |
Clear Cell Focus | X |
Hyperplasia, Focal | 2 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 4 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ectopic Thymus | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|
| 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 1 2 3 1 2 1 1 2|
Inflammation, Subacute | 1 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + M + + + + + + I + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 2|
Cyst | X X X X X |
Hyperplasia | |
Artery, Necrosis, Fibrinoid | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 |
Hydrometra | 3 4 3 4 4 4 4 2 |
Hyperplasia, Cystic | 3 3 3 2 4 2 3 3 3 4 3 2 3 2 3 1 2 3 3 3 4 4 2 3 3|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | 4 |
Iliac, Angiectasis | 4 4 |
Iliac, Hyperplasia, Plasma Cell | 4 3 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + I + + + +|
Hyperplasia, Lymphoid | 2 3 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 2 2 1 3 3 1 1 |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|
| 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 3 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X |
Depletion Cellular | 3 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 4 3 |
Artery, Necrosis, Fibrinoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Thalamus, Mineralization | 1 2 3 2 2 1 1 3 3 1 1 2 2 3 3 3 2 3 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 1 2 1 1 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|
| 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 3 1 1 1 |
Glomerulosclerosis | 2 |
Hydronephrosis | 2 4 |
Hyperplasia, Lymphoid | 1 1 1 3 2 2 2 1 1 1 1 2 |
Inflammation, Suppurative | 3 |
Metaplasia, Osseous | 3 |
Mineralization | 2 1 1 1 3 1 1 1 2|
Papilla, Necrosis | 4 |
Renal Tubule, Atrophy | 2 2 2 |
Renal Tubule, Dilatation | 3 1 3 |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Regeneration | 1 3 1 1 1 2 2 1 1 1 1 3 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Ureter | + |
Dilatation | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | 2 2 1 1 2 2 1 3 2 1 |
Inflammation, Subacute | 3 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|
| 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + I + + + A + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Artery, Jejunum, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 1 2 3 |
Hemorrhage | 1 |
Hyperplasia, Focal | 3 |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic | 1 |
Inflammation, Subacute | 1 1 |
Mineralization | |
Mixed Cell Focus | |
Artery, Necrosis, Fibrinoid | |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Edema | |
Artery, Necrosis, Fibrinoid | |
Fat, Inflammation, Suppurative | |
Fat, Necrosis | 2 3 3 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 3 1 1 1 1 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|
| 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 2 1 3 2 3 2 3 2 2 2 2 1 2|
Acinus, Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Diverticulum | 3 |
Edema | |
Inflammation, Suppurative | |
Ulcer | 1 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Edema | |
Erosion | |
Inflammation, Subacute | 2 2 |
Metaplasia, Squamous | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Necrosis, Fibrinoid | |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Subacute | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Basophilic Focus | X X X|
Clear Cell Focus | |
Hyperplasia, Focal | 2 |
Capsule, Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M + + + + + + + + + + + + +|
Ectopic Thymus | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|
| 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 2 3 2 2 1 1 1 2 2 1 1|
Inflammation, Subacute | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + I + + + + + + + + +|
Angiectasis | 2 2 3 2 3|
Cyst | X X X X X |
Hyperplasia | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hydrometra | 4 3 4 2 4 3 3 4 4|
Hyperplasia, Cystic | 2 3 3 3 3 2 3 2 3 2 4 4 2 1 2 1 2 3 3 3 3 2 2 3|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | |
Iliac, Angiectasis | |
Iliac, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + I|
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 1 1 3 2 4 |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|
| 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 3 |
Red Pulp, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X |
Depletion Cellular | 3 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 3 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | X |
Thalamus, Mineralization | 1 1 2 2 1 3 3 3 2 2 3 3 1 2 2 3 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 1 |
Infiltration Cellular, Histiocyte | 1 3 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|
| 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1|
Glomerulosclerosis | |
Hydronephrosis | 4 |
Hyperplasia, Lymphoid | 2 1 1 2 1 3 2 1 3 3 1 3 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | |
Renal Tubule, Atrophy | 4 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 4 1|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Lymphoid | 1 1 1 1 2 2 1 1 1 1 2 2 |
Inflammation, Subacute | 3 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + I + + + + + + + | 57 |
Cyst | | 3 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Edema | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Artery, Jejunum, Necrosis, Fibrinoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 3.5|
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | | 5 1.6|
Hemorrhage | 1 | 2 1.0|
Hyperplasia, Focal | 2 2 2 3 | 12 2.4|
Hyperplasia, Lymphoid | 1 | 6 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Subacute | 1 | 5 1.4|
Mineralization | 3 | 1 3.0|
Mixed Cell Focus | | 1 |
Artery, Necrosis, Fibrinoid | | 1 4.0|
Hepatocyte, Karyomegaly | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 1.7|
Kupffer Cell, Hyperplasia | | 1 2.0|
Kupffer Cell, Pigmentation | 1 | 2 2.0|
Lobules, Necrosis | 2 | 6 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 17 |
Edema | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | | 1 4.0|
Fat, Inflammation, Suppurative | 3 | 1 3.0|
Fat, Necrosis | 4 3 3 | 14 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 1 | 3 1.3|
Cytoplasmic Alteration | | 2 2.5|
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 8 1.5|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | 2 1 1 1 | 24 1.8|
Acinus, Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst | | 1 |
Diverticulum | | 1 3.0|
Edema | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 1.0|
Mucosa, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | X X X | 10 |
Edema | | 2 2.0|
Erosion | | 1 2.0|
Inflammation, Subacute | | 3 2.0|
Metaplasia, Squamous | 2 | 1 2.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Necrosis, Fibrinoid | | 1 4.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Myocardium, Inflammation, Subacute | | 1 3.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X X | 11 |
Basophilic Focus | | 3 |
Clear Cell Focus | | 1 |
Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Ectopic Thymus | X | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Hyperplasia | 1 1 | 9 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 | 26 1.7|
Inflammation, Subacute | 1 | 2 1.0|
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | 1 | 12 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | I + + + + + + + + + | 56 |
Angiectasis | | 11 2.2|
Cyst | X X X | 13 |
Hyperplasia | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 5 2.4|
Hydrometra | 2 3 3 | 20 3.4|
Hyperplasia, Cystic | 2 3 2 2 2 2 3 3 3 2 | 59 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | 2 2 2 | 5 2.2|
Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 7 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Artery, Necrosis, Fibrinoid | | 1 4.0|
Iliac, Angiectasis | | 2 4.0|
Iliac, Hyperplasia, Plasma Cell | | 2 3.5|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 5 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | 2 | 4 2.0|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 3 2 | 21 2.4|
Hemorrhage | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 5 2.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia | 3 | 4 3.0|
Red Pulp, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Angiectasis | 2 2 | 3 2.0|
Cyst | | 9 |
Depletion Cellular | | 3 3.0|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | 4 | 3 3.7|
Artery, Necrosis, Fibrinoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 2 | 1 2.0|
Hyperostosis | 3 | 6 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Cyst | X | 2 |
Thalamus, Mineralization | 3 1 2 2 1 1 | 48 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Edema | 2 | 1 2.0|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 10 1.6|
Infiltration Cellular, Histiocyte | 3 | 3 2.3|
Inflammation, Chronic | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X | 3 |
Glands, Hyperplasia, Cystic | 2 | 5 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 2 1 1 | 14 1.2|
Glomerulosclerosis | 2 | 2 2.0|
Hydronephrosis | | 3 3.3|
Hyperplasia, Lymphoid | 1 2 2 | 27 1.7|
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 1 1 2 1 1 1 | 25 1.2|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Atrophy | | 4 2.5|
Renal Tubule, Dilatation | 3 | 5 2.6|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Regeneration | 1 2 3 1 1 1 1 1 | 41 1.3|
Transitional Epithelium, Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 2| 3| 7| 7| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Dilatation | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 1 4.0|
Hyperplasia, Lymphoid | 2 2 1 2 | 26 1.5|
Inflammation, Subacute | 3 | 3 3.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 8| 8| 7| 1| 0| 1| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + M + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 8| 8| 7| 1| 0| 1| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 1 | 2 1.5|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0.0200% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 2 3 2 |
Hyperplasia, Lymphoid | 1 1 1 |
Inflammation, Chronic | 2 1 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
Cytoplasmic Alteration | 4 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Inflammation, Subacute | 3 |
Metaplasia, Squamous | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0.0200% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hypertrophy | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X|
Basophilic Focus | X |
Clear Cell Focus | X |
Cyst | |
Hyperplasia, Focal | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + +|
Ectopic Thymus | |
Pigmentation | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Degeneration, Cystic | 1 3 1 1 1 2 1 2 1 |
Inflammation, Subacute | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + I M + I + + + + +|
Angiectasis | 2 2 3 3 2 2|
Cyst | X X X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hemorrhage | 2 |
Hydrometra | 3 3 4 3 |
Hyperplasia, Cystic | 2 3 3 3 2 3 3 3 4 3 2 4 3 2 2 2 3 2 2 4 2 3 3 3|
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0.0200% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | X 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + M + + + +|
Hemorrhage | 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 2 1 1 1 3 2 3 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 2 2 |
Red Pulp, Atrophy | |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + M|
Angiectasis | 2 |
Cyst | X |
Depletion Cellular | 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 |
Hyperplasia, Lobular | 1 |
__________________________________________________________________________|
Skin | + + + + + + I + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 4 2 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Inflammation, Chronic | 1 |
Thalamus, Mineralization | 1 1 2 1 2 2 2 2 3 1 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0.0200% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 1 1 1 2 1 |
Infiltration Cellular, Histiocyte | 4 1 1 2 1 1 |
Inflammation, Chronic | |
Leukocytosis | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
Cyst | X |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Casts Protein | 1 1 1 |
Cyst | |
Hemorrhage | 3 2 |
Hyperplasia, Lymphoid | 1 3 1 1 1 1 1 1 2 1 1|
Metaplasia, Osseous | 1 |
Mineralization | 1 2 1 1 1 1 |
Renal Tubule, Atrophy | 2 3 3 3 1 3 2 2|
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 2 1 2 1 1 2 2 3 3 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|
| 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 1 3 3 4 3 |
Hyperplasia, Lymphoid | 2 2 2|
Inflammation, Chronic | 3 |
Inflammation, Subacute | 1 1 |
Mixed Cell Focus | X |
Kupffer Cell, Hyperplasia | 3 3|
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | X |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cyst | X |
Cytoplasmic Alteration | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 2 2 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Inflammation, Subacute | 2 |
Metaplasia, Squamous | 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|
| 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hypertrophy | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X X|
Basophilic Focus | |
Clear Cell Focus | |
Cyst | X |
Hyperplasia, Focal | |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
Pigmentation | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 2 1 2 1 1 1 |
Inflammation, Subacute | 2 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 4 2 3 2 2 |
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Hemorrhage | |
Hydrometra | 3 3 4 3 3 3 4 |
Hyperplasia, Cystic | 3 3 3 2 3 3 3 3 4 3 3 3 2 3 3 3 2 2 3 3 3 3 2|
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|
| 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + M + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 1 2 3 1 3 2 1 2|
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Hyperplasia | 1 3 2 2 |
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thymus | + M M + + + + + + M + M M + M + + M + + + + + + +|
Angiectasis | |
Cyst | X |
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + I + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Inflammation, Chronic | |
Thalamus, Mineralization | 2 2 2 2 3 2 2 1 2 3 1 2 2 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|
| 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 3 2 2|
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Chronic | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Cyst | |
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Casts Protein | 1 1 1 1 |
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 3 1 2 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 2 1 |
Renal Tubule, Atrophy | |
Renal Tubule, Pigmentation | 4 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 2 1 1 2 2 3 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Edema | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Focal | 3 | 9 2.7|
Hyperplasia, Lymphoid | 1 1 3 | 9 1.6|
Inflammation, Chronic | | 3 2.0|
Inflammation, Subacute | 1 | 4 1.0|
Mixed Cell Focus | | 1 |
Kupffer Cell, Hyperplasia | | 2 3.0|
Kupffer Cell, Pigmentation | | 1 3.0|
Lobules, Necrosis | | 5 1.2|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Accessory Spleen | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
Cyst | | 1 |
Cytoplasmic Alteration | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 2 1 1 3 2 1 2 2 | 19 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + | 59 |
Diverticulum | | 2 2.5|
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + | 59 |
Cyst | X | 10 |
Inflammation, Subacute | 2 | 3 2.3|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Hypertrophy | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 17 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Cyst | X | 2 |
Hyperplasia, Focal | 1 | 1 1.0|
Capsule, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 6 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Ectopic Thymus | X | 1 |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 | 7 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 2 2 | 21 1.5|
Inflammation, Subacute | 1 1 | 3 1.3|
Follicle, Cyst | | 3 |
Follicular Cell, Hyperplasia | | 9 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 2 | 15 2.4|
Cyst | X X X | 20 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 4 2.5|
Hemorrhage | | 1 2.0|
Hydrometra | 4 2 3 | 14 3.2|
Hyperplasia, Cystic | 2 2 3 3 3 2 3 2 3 | 56 2.8|
Inflammation, Suppurative | 2 | 4 2.3|
Metaplasia, Squamous | | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Hemorrhage | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 18 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Hyperplasia | 3 3 3 | 9 2.3|
Red Pulp, Atrophy | | 1 2.0|
Red Pulp, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 51 |
Angiectasis | 3 | 2 2.5|
Cyst | X X X | 5 |
Depletion Cellular | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 2 1.5|
Hyperplasia, Lobular | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 2 1.0|
Inflammation, Chronic | | 1 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 7 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | 2 1 2 1 2 | 39 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Lymphoid | 1 2 | 13 1.5|
Infiltration Cellular, Histiocyte | 1 | 9 1.7|
Inflammation, Chronic | | 1 2.0|
Leukocytosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 2 |
Glands, Hyperplasia, Cystic | | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
Cyst | | 1 |
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
Casts Protein | | 7 1.0|
Cyst | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | 2 2 2 | 23 1.4|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 | 13 1.2|
Renal Tubule, Atrophy | | 8 2.4|
Renal Tubule, Pigmentation | | 1 4.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 3 1 1 2 2 1 2 | 35 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 8| 8| 7| 1| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 8| 8| 7| 1| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Cyst | 2 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|
| 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0.0100% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + M + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X 3 X|
Clear Cell Focus | X |
Hemorrhage | |
Hyperplasia, Focal | 3 2 |
Hyperplasia, Lymphoid | 2 1 |
Inflammation, Chronic | 1 |
Inflammation, Subacute | 2 3 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 2 |
Lobules, Necrosis | 1 4 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
Cytoplasmic Alteration | 4 4 4 4 |
Focal Cellular Change | X |
Hyperplasia, Lymphoid | 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 2 3 1 1 3 1 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
Inflammation, Suppurative | 1 |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | |
Erosion | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|
| 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0.0100% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Basophilic Focus | X|
Cyst | |
Hyperplasia, Focal | 2 1 3 |
Capsule, Hyperplasia | |
X-Zone, Degeneration, Fatty | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Thymus | X X |
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + M + + + M + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 2 1 1 1 2 2 |
Ectopic Thymus | X |
Inflammation, Subacute | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Diffuse| 4 |
Follicular Cell, Hyperplasia, Focal | 3 |
Follicular Cell, Hyperplasia | 1 1 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 4 2 2 2 2 |
Cyst | X X X X X X X X X X |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|
| 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0.0100% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 4 2 |
Granuloma | 2 |
Hydrometra | 3 2 3 3 4 3 |
Hyperplasia, Cystic | 1 4 3 3 3 2 2 3 3 3 3 1 3 2 3 2 2 3 2 3 2 2 3 1|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 1 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + I + + + I|
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 3 1 2 3 1 1 2 |
Hemorrhage | |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Hyperplasia | 2 2 3 |
Red Pulp, Hyperplasia | 1 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 2 |
Cyst | X X |
Depletion Cellular | 3 4 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|
| 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0.0100% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hydrocephalus | 2 |
Thalamus, Mineralization | 1 1 3 2 2 2 2 1 1 1 3 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 2 3 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 1 1 2 2 2 1 2|
Infiltration Cellular, Histiocyte | 1 2 |
Leukocytosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Cystic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 2 |
Cyst | X|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 1 2 1 2 |
Metaplasia, Osseous | 2 1 |
Mineralization | 2 1 2 1 |
Thrombosis | |
Interstitium, Pigmentation | 3 |
Renal Tubule, Atrophy | 2 2 |
Renal Tubule, Casts Protein | |
Renal Tubule, Dilatation | 2 2 2 2 2 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | 2 1 3 1 1 2 1 1 3 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 2 1 3 1 1 2 1 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X 3 X |
Clear Cell Focus | |
Hemorrhage | 1 |
Hyperplasia, Focal | 2 3 2 3 2 3 |
Hyperplasia, Lymphoid | 1 3 |
Inflammation, Chronic | |
Inflammation, Subacute | 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 1 4 2 1 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 4 4 2 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + I + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 2 1 1 2 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | 2 |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Basophilic Focus | |
Cyst | |
Hyperplasia, Focal | 1 2 |
Capsule, Hyperplasia | 2 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + M + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + +|
Cyst | |
Ectopic Thymus | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1 1|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 1 1 1 2 2 2 2 1 1 |
Ectopic Thymus | |
Inflammation, Subacute | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 2 |
Cyst | X X X X |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 2 4 4 |
Granuloma | |
Hydrometra | 2 2 4 4 4 4 4 3 4 3 |
Hyperplasia, Cystic | 2 3 2 3 3 3 3 3 2 2 3 3 2 2 3 3 3 3 2 2 3|
Hyperplasia, Lymphoid | 1 2 |
Inflammation, Suppurative | |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 |
Hemorrhage | |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 2 3 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 3 |
Cyst | X X |
Depletion Cellular | 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hydrocephalus | |
Thalamus, Mineralization | 2 3 1 3 1 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 1 1 |
Infiltration Cellular, Histiocyte | |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Cystic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 |
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 2 1 2 1 1 1 4 |
Metaplasia, Osseous | 3 1|
Mineralization | 2 1 1 2 |
Thrombosis | X |
Interstitium, Pigmentation | |
Renal Tubule, Atrophy | 2 1 4 |
Renal Tubule, Casts Protein | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + I + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 1 3 1 1 1 1 1 2 2 1 3|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 2| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 48 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X | 7 3.0|
Clear Cell Focus | | 1 |
Hemorrhage | | 1 1.0|
Hyperplasia, Focal | 3 | 9 2.6|
Hyperplasia, Lymphoid | | 4 1.8|
Inflammation, Chronic | | 1 1.0|
Inflammation, Subacute | 1 | 7 1.4|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Hyperplasia | | 1 2.0|
Lobules, Necrosis | 2 | 10 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Fat, Necrosis | | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Atrophy | 3 | 2 2.5|
Cyst | | 1 |
Cytoplasmic Alteration | | 5 3.8|
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 5 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | | 22 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Inflammation, Subacute | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
Mucosa, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 2| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | X | 7 |
Edema | | 1 2.0|
Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Myocardium, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X X | 9 |
Basophilic Focus | | 1 |
Cyst | X | 1 |
Hyperplasia, Focal | | 5 1.8|
Capsule, Hyperplasia | | 1 2.0|
X-Zone, Degeneration, Fatty | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 48 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | | 6 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 49 |
Cyst | | 1 |
Ectopic Thymus | | 2 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 47 |
Pars Distalis, Angiectasis | | 4 1.0|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | 1 2 | 23 1.6|
Ectopic Thymus | | 1 |
Inflammation, Subacute | 1 1 | 3 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Diffuse| | 1 4.0|
Follicular Cell, Hyperplasia, Focal | | 1 3.0|
Follicular Cell, Hyperplasia | 2 1 | 10 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 2| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + M + + + | 48 |
Angiectasis | | 10 2.4|
Cyst | X X X | 17 |
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 59 |
Angiectasis | | 5 3.2|
Granuloma | | 1 2.0|
Hydrometra | 4 4 | 18 3.3|
Hyperplasia, Cystic | 3 1 3 2 2 2 2 3 2 | 54 2.5|
Hyperplasia, Lymphoid | | 2 1.5|
Inflammation, Suppurative | 1 | 3 1.3|
Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 47 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Hematopoietic Cell Proliferation | 1 | 13 2.0|
Hemorrhage | 4 | 1 4.0|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 5 2.4|
Red Pulp, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + | 47 |
Angiectasis | | 2 2.5|
Cyst | | 4 |
Depletion Cellular | | 3 3.3|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 2| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 49 |
Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 49 |
Acanthosis | 1 | 2 1.0|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | | 7 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | | 1 |
Hydrocephalus | | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 | 33 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 5 2.4|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 1 | 12 1.4|
Infiltration Cellular, Histiocyte | | 2 1.5|
Leukocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Glands, Hyperplasia, Cystic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 57 |
Casts Protein | 1 | 6 1.2|
Cyst | | 1 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 1 1 | 15 1.5|
Metaplasia, Osseous | | 4 1.8|
Mineralization | | 8 1.5|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 2| 3| 1| 3| 3| 6| 7| 6| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Interstitium, Pigmentation | | 1 3.0|
Renal Tubule, Atrophy | 1 | 6 2.0|
Renal Tubule, Casts Protein | | 1 1.0|
Renal Tubule, Dilatation | 2 | 6 2.0|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | 2 1 1 1 1 1 1 2 | 42 1.2|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 49 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | 1 2 | 27 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 9| 7| 8| 9| 7| 1| 0| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
Endometrium, Cyst | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 2 3 2 3 3 |
Hyperplasia, Lymphoid | 1 1 |
Inflammation, Chronic | |
Inflammation, Subacute | 1 |
Centrilobular, Necrosis | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 1 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cytoplasmic Alteration | 3 2 |
Hyperplasia, Lymphoid | 1 1 1 2 1 1 3 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 1 1 1 1 1 2 1 2|
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | 1 |
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X |
Cyst | |
X-Zone, Degeneration, Fatty | 1 |
Zona Reticularis, Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 4 |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 2 |
Follicular Cell, Hyperplasia | 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + + + I|
Angiectasis | 2 2 3 1 2 4 2 2 |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hydrometra | 3 3 3 3 3 |
Hyperplasia, Cystic | 3 3 2 2 3 2 2 1 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 3 3|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 2 4 3 4 2 |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 2|
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | 2 3|
__________________________________________________________________________|
Thymus | I + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X |
Depletion Cellular | 2 2 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic, Focal | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 1 2 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Parenchyma, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Thalamus, Mineralization | 2 2 2 2 2 2 1 2 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 1 1 |
Leukocytosis | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 1 1 3 1 |
Cyst | X |
Glomerulosclerosis | 3 |
Hemorrhage | |
Hydronephrosis | |
Hyperplasia, Lymphoid | 1 1 2 1 3 1 1 4 2 3 |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 |
Interstitium, Pigmentation | 3 |
Renal Tubule, Atrophy | 1 1 3 2 |
Renal Tubule, Dilatation | 1 3 1 |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 1 1 1 2 1 1 1 1 1 1 1 4 1 1 1 2 1 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 3 1 1 1 1 1 1 1 3 1 2 3 1|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|
| 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + M M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 X |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Focal | 3 2 4 3 2|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 |
Inflammation, Subacute | 1 1 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 4 1 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 1 1|
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Fibrosis | |
Mucosa, Hyperplasia | 1 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | 2 |
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|
| 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Cyst | X X |
X-Zone, Degeneration, Fatty | |
Zona Reticularis, Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + +|
Degeneration, Cystic | 2 4 2 1 1 1 3 1 2 1|
Hyperplasia, Lymphoid | 3 |
Inflammation, Subacute | 1 1 |
Follicular Cell, Hyperplasia | 3 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + M + + + + + + +|
Angiectasis | 2 3 |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Hydrometra | 2 3 3 2 4 4 3 |
Hyperplasia, Cystic | 2 2 2 2 2 3 2 2 2 2 2 3 1 2 2 2 2 3 4 2 3 2 3 2 2|
Hyperplasia, Lymphoid | 2|
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|
| 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 3 3 2 2 2 3 2 1 3 |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Atrophy | 2 2 |
Lymphoid Follicle, Hyperplasia | 3 2 2|
Red Pulp, Atrophy | |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Cyst | X X X |
Depletion Cellular | 3 3 3 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Inflammation, Chronic, Focal | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|
| 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
ANIMAL ID | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Parenchyma, Vacuolization | |
Cytoplasmic, Diffuse | |
Thalamus, Mineralization | 1 1 1 3 1 3 1 2 3 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 4 |
Leukocytosis | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 2 1 |
Cyst | |
Glomerulosclerosis | |
Hemorrhage | |
Hydronephrosis | 2 2 |
Hyperplasia, Lymphoid | 2 1 1 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1|
Interstitium, Pigmentation | |
Renal Tubule, Atrophy | 4 1 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 2 2 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 2 1 4 2 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 8| 7| 6| 8| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | A |
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Basophilic Focus | X | 3 3.0|
Clear Cell Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Hyperplasia, Focal | 3 | 11 2.7|
Hyperplasia, Lymphoid | | 2 1.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Subacute | | 3 1.0|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Karyomegaly | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 2.3|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
Lobules, Necrosis | 3 | 4 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Fat, Necrosis | 4 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | | 1 2.0|
Cytoplasmic Alteration | | 2 2.5|
Hyperplasia, Lymphoid | | 9 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | 1 | 15 1.5|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Edema | | 1 2.0|
Fibrosis | | 1 1.0|
Mucosa, Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Cyst | X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 8| 7| 6| 8| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | A |
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Mucosa, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X | 10 |
Cyst | | 2 |
X-Zone, Degeneration, Fatty | 3 | 2 2.0|
Zona Reticularis, Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | | 8 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 49 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 1 4.0|
Pars Distalis, Hyperplasia | | 6 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 49 |
Degeneration, Cystic | 1 1 | 26 1.4|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Inflammation, Subacute | | 3 1.3|
Follicular Cell, Hyperplasia | 4 2 | 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 46 |
Angiectasis | 2 3 3 | 13 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 8| 7| 6| 8| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | A |
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X X X | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 3 | 4 3.3|
Hydrometra | 4 4 | 14 3.1|
Hyperplasia, Cystic | 3 2 2 3 1 2 3 3 2 | 59 2.3|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Suppurative | | 2 2.0|
Metaplasia, Squamous | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + | 49 |
Hyperplasia, Lymphoid | | 4 3.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 4 | 3 2.0|
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 4 | 19 2.6|
Pigmentation, Hemosiderin | 2 | 4 2.0|
Lymphoid Follicle, Atrophy | | 2 2.0|
Lymphoid Follicle, Hyperplasia | 2 | 7 2.1|
Red Pulp, Atrophy | | 1 2.0|
Red Pulp, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + | 47 |
Angiectasis | 2 | 1 2.0|
Cyst | X | 10 |
Depletion Cellular | 3 | 6 2.7|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 8| 7| 6| 8| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | A |
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Hyperplasia, Lobular | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Acanthosis | | 2 1.0|
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | 2 | 9 1.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | | 1 |
Necrosis | | 1 2.0|
Parenchyma, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
Thalamus, Mineralization | 2 1 1 | 27 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Hemorrhage | | 3 1.0|
Hyperplasia, Lymphoid | 1 | 9 1.2|
Infiltration Cellular, Histiocyte | | 3 2.0|
Leukocytosis | 2 | 1 2.0|
Thrombosis | | 2 |
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | | 2 |
Glands, Hyperplasia, Cystic | | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 8| 7| 6| 8| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | A |
0.00500% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Casts Protein | | 10 1.4|
Cyst | | 1 |
Glomerulosclerosis | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Hydronephrosis | | 2 2.0|
Hyperplasia, Lymphoid | 3 | 14 1.9|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 | 9 1.0|
Interstitium, Pigmentation | | 1 3.0|
Renal Tubule, Atrophy | 2 | 7 2.0|
Renal Tubule, Dilatation | | 4 2.0|
Renal Tubule, Pigmentation | | 1 1.0|
Renal Tubule, Regeneration | 1 1 | 34 1.2|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 49 |
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 3 | 21 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 8| 7| 1| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 8| 8| 8| 8| 9| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 9| 9| 9| 9| 0| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
Endometrium, Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
Renal Tubule, Regeneration | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|
| 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0275% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X X X |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia, Focal | 2 2 1 2 2 2 2 3 3 2|
Hyperplasia, Lymphoid | 1 3 2 1 |
Inflammation, Chronic | 2 |
Inflammation, Subacute | 1 1 1 |
Mineralization | |
Mixed Cell Focus | |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Karyomegaly | 2 2 |
Hepatocyte, Nuclear Alteration | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 4 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 1 1 2 1 2 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Diverticulum | 2 |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|
| 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0275% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Erosion | 2 3 |
Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Hypertrophy | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Cyst | X |
Hyperplasia, Focal | 2 2 |
Necrosis | |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 1 2 2 1 1 3 2 1 2 2|
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + I + + + + +|
Angiectasis | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|
| 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0275% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X X X X X X |
Hyperplasia, Cystic | |
Hyperplasia | 2 2 |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hydrometra | 1 3 4 4 3 4 4 3 |
Hyperplasia, Cystic | 3 3 3 2 4 3 2 2 2 3 3 1 2 3 3 3 1 4 2 4 3 3 4 3 2|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hypercellularity | 2 X |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Lymphatic, Dilatation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 1 1 3 2 3 1 1 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Atrophy | 3 2 |
Lymphoid Follicle, Hyperplasia | 3 2 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + M + + M + + M + + M + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X |
Depletion Cellular | 3 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|
| 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0275% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 2 |
Hydrocephalus | 2 |
Thalamus, Mineralization | 2 2 2 1 2 1 1 2 1 2 1 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 4 |
Hyperplasia, Lymphoid | 1 1 2 1 2 |
Infiltration Cellular, Histiocyte | 1 3 4 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Focal | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|
| 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0275% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 3 1 1 |
Cyst | X X|
Glomerulosclerosis | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 3 1 1 1 1 1 2 2|
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 2 1 1 1|
Interstitium, Pigmentation | 2 |
Papilla, Necrosis | 2 |
Renal Tubule, Atrophy | 3 2 1 3|
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 1 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|
| 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + I + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Hyperplasia, Focal | 2 |
Hyperplasia, Lymphoid | 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Subacute | 1 |
Mineralization | 4|
Mixed Cell Focus | X |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Nuclear Alteration | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 2 2 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 2 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 |
Cytoplasmic Alteration | 4 |
Focal Cellular Change | X |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 2 1 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Diverticulum | |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|
| 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Erosion | |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Hypertrophy | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Cyst | |
Hyperplasia, Focal | 1 1 1 |
Necrosis | 1 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 2 1 1 1 2 1 1 1 1|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Subacute | 1 |
Follicular Cell, Hyperplasia | 3 1 1 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + M + + M + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|
| 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X |
Hyperplasia, Cystic | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 3 4 4 4 2 4 4 4 3 |
Hyperplasia, Cystic | 2 2 2 3 3 2 2 2 2 2 3 1 2 2 4 3 3 3 3 3 1 2 2|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 2 2 2 |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | 3 4 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hematopoietic Cell | |
Proliferation | 4 |
Renal, Hematopoietic Cell | |
Proliferation | 3 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + I + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | 3 |
Hematopoietic Cell Proliferation | 1 3 4 4 2 4 2 1 2 1 1 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Atrophy | 2 3 |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 |
Cyst | X X X |
Depletion Cellular | 2 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|
| 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Hydrocephalus | |
Thalamus, Mineralization | 2 2 2 2 1 2 2 2 2 2 3 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 |
Hemorrhage | 1 3 |
Hyperplasia, Lymphoid | 2 2 1 2 1 2 3|
Infiltration Cellular, Histiocyte | 4 2 2 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
Retina, Atrophy | 4|
__________________________________________________________________________|
Harderian Gland | + + + + + +|
Hyperplasia, Focal | 1 1|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|
| 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1|
Cyst | X X |
Glomerulosclerosis | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 2 1 1 1 1 1 1 3 |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 2 |
Interstitium, Pigmentation | |
Papilla, Necrosis | |
Renal Tubule, Atrophy | 1 1 2 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 3 4 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 8| 1| 6| 8| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | 3 3 X | 6 3.0|
Clear Cell Focus | | 4 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal | 2 | 12 2.1|
Hyperplasia, Lymphoid | | 7 1.4|
Inflammation, Chronic | 1 | 3 1.3|
Inflammation, Subacute | 1 | 5 1.0|
Mineralization | | 1 4.0|
Mixed Cell Focus | | 1 |
Hepatocyte, Cytomegaly | | 1 2.0|
Hepatocyte, Karyomegaly | | 2 2.0|
Hepatocyte, Nuclear Alteration | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 3 2.0|
Kupffer Cell, Hyperplasia | 3 | 3 2.3|
Kupffer Cell, Pigmentation | | 1 2.0|
Lobules, Necrosis | 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Fat, Necrosis | 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 3 1.3|
Cytoplasmic Alteration | 4 | 3 3.7|
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 4 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 2 1 2 | 20 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 8| 1| 6| 8| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Diverticulum | | 1 2.0|
Erosion | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 5 |
Erosion | | 2 2.5|
Inflammation, Subacute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Myocardium, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 13 |
Cyst | | 1 |
Hyperplasia, Focal | | 5 1.4|
Necrosis | | 1 1.0|
X-Zone, Degeneration, Fatty | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 8 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 2 2.5|
Pars Distalis, Hyperplasia | | 7 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 1 | 29 1.6|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Subacute | 3 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 8| 1| 6| 8| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 4 | 14 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 56 |
Angiectasis | 2 | 7 2.3|
Cyst | | 16 |
Hyperplasia, Cystic | 3 | 1 3.0|
Hyperplasia | | 2 2.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.3|
Hydrometra | 2 4 3 3 | 21 3.3|
Hyperplasia, Cystic | 2 2 3 2 2 2 3 2 3 3 | 58 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | | 3 2.0|
Metaplasia, Squamous | 2 | 3 2.3|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Hypercellularity | 2 | 6 2.6|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 58 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 8| 1| 6| 8| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 | 2 2.5|
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Congestion | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 2 3 | 22 2.1|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Hemosiderin | | 4 2.0|
Lymphoid Follicle, Atrophy | | 4 2.5|
Lymphoid Follicle, Hyperplasia | | 5 2.2|
Red Pulp, Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Angiectasis | 3 | 3 2.3|
Cyst | X X X | 10 |
Depletion Cellular | | 4 2.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 7 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 1 | 33 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 8| 1| 6| 8| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 3 2.3|
Hemorrhage | 1 1 | 7 1.7|
Hyperplasia, Lymphoid | 1 | 13 1.6|
Infiltration Cellular, Histiocyte | 3 | 7 2.7|
Inflammation, Chronic | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X | 5 |
Glands, Hyperplasia, Cystic | 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 8 |
Hyperplasia, Focal | 1 | 3 1.0|
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 | 7 1.4|
Cyst | X | 5 |
Glomerulosclerosis | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 22 1.5|
Metaplasia, Osseous | 3 2 | 3 2.0|
Mineralization | 1 | 13 1.2|
Interstitium, Pigmentation | | 1 2.0|
Papilla, Necrosis | | 1 2.0|
Renal Tubule, Atrophy | 3 2 | 10 1.9|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | | 2 3.5|
Renal Tubule, Regeneration | 1 1 1 1 | 34 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 3 | 20 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 8| 9| 7| 9| 2| 0| 2| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 | 2 1.0|
Lobules, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | M + + + + + + + + + | 9 |
Accessory Adrenal Cortical Nodule | X X X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
Ectopic Thymus | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 8| 9| 7| 9| 2| 0| 2| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + M | 9 |
Cyst | X | 1 |
Developmental Malformation | X | 1 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Hypercellularity | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
Hyperplasia, Lobular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 8| 9| 7| 9| 2| 0| 2| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|
| 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.0140% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + M +|
Cyst | |
Dilatation | |
Hyperplasia, Lymphoid | 2 |
Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X|
Hematopoietic Cell Proliferation | 2 4 4 |
Hemorrhage | |
Hyperplasia, Focal | 2 3 |
Inflammation, Subacute | 2 3 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 |
Kupffer Cell, Hyperplasia | 2 2 2|
Lobules, Necrosis | 1 3 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 3 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Atrophy | 1|
Cyst | X |
Cytoplasmic Alteration | 3 3 3 4 3|
Focal Cellular Change | X |
Hyperplasia, Lymphoid | 1 2 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Suppurative | 1 2|
Ulcer | 1 |
Mucosa, Hyperplasia | 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|
| 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.0140% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Edema | |
Erosion | |
Inflammation, Subacute | 2 |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Cyst | X |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + M + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 2 2 3 1 2 3 2|
Inflammation, Subacute | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Ectasia | |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 4 |
Cyst | X X X X X X X X |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|
| 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.0140% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Hydrometra | 3 4 4 4 2 4 3 2 3 4 3 4 |
Hyperplasia, Cystic | 2 2 2 3 2 2 4 3 2 4 2 1 2 2 3 1 2 2 2 3 2 2|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 4 |
Metaplasia, Squamous | 1|
Myometrium, Fibrosis | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | X 2 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Lymphatic, Dilatation | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 2 1 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 4 4 4 2 1 4 2|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 |
Red Pulp, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + I + + + + + M|
Angiectasis | 2 |
Cyst | X X X X |
Depletion Cellular | 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|
| 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.0140% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 3 1 2|
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 3 |
Hydrocephalus | 2 |
Inflammation, Chronic | |
Necrosis | 2 |
Thalamus, Mineralization | 2 1 2 1 2 2 2 2 1 3 2 1 2 2 2 2 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 2 2 2 1 1 |
Infiltration Cellular, Histiocyte | 3 |
Leukocytosis | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X|
Glands, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + |
Cyst | |
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 |
Glomerulosclerosis | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|
| 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.0140% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | |
Hyperplasia, Lymphoid | 1 1 1 2 1 |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 1 3|
Interstitium, Pigmentation | 1 |
Renal Tubule, Atrophy | 1 2 1 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | 1 2 1 1 1 1 1 1 1 3 1 1 1 1 4 3|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 1 1 2 1 1 1 3 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Dilatation | 3 |
Hyperplasia, Lymphoid | |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X 3 |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Hyperplasia, Focal | 2 3 |
Inflammation, Subacute | 1 1|
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 1 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Cytoplasmic Alteration | 4 3 |
Focal Cellular Change | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Suppurative | |
Ulcer | |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Edema | |
Erosion | 1 |
Inflammation, Subacute | |
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Cyst | |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 3 |
Pars Distalis, Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 2 3 1 2 1 1 4 2 1|
Inflammation, Subacute | 1|
Follicle, Cyst | X X X|
Follicular Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 3 3 3 2 |
Cyst | X X X X X X X X|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 |
Hydrometra | 4 3 3 3 3 3 3 3 |
Hyperplasia, Cystic | 3 1 1 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2 2|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Suppurative | 2|
Metaplasia, Squamous | 1 |
Myometrium, Fibrosis | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Lymphatic, Dilatation | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 4 4 2 3 4 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 2 2|
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2|
Cyst | X |
Depletion Cellular | 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Hydrocephalus | |
Inflammation, Chronic | 2 |
Necrosis | 3 |
Thalamus, Mineralization | 1 2 2 1 2 2 2 2 2 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 1 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 1 1 2 2 1 |
Infiltration Cellular, Histiocyte | 3 3 3 3 |
Leukocytosis | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
Cyst | X |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 |
Glomerulosclerosis | 1 1 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | 2 1 1 2 2 1 1|
Metaplasia, Osseous | 2 |
Mineralization | 1 1 2 |
Interstitium, Pigmentation | 1 |
Renal Tubule, Atrophy | 1 1 2 1 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 3 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 2 1 1 1 2 3 3 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 1 1 3 1 1 1 3 1 2|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 0| 8| 2| 8| 7| 6| 8| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 48 |
Cyst | | 1 |
Dilatation | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Edema | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Basophilic Focus | | 2 3.0|
Clear Cell Focus | | 4 |
Hematopoietic Cell Proliferation | 4 | 5 3.2|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal | | 4 2.5|
Inflammation, Subacute | | 4 1.8|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 6 2.7|
Kupffer Cell, Hyperplasia | | 3 2.0|
Lobules, Necrosis | | 8 1.6|
__________________________________________________________________________|____________|
Mesentery | + | 12 |
Fat, Necrosis | | 7 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Atrophy | | 1 1.0|
Cyst | | 1 |
Cytoplasmic Alteration | | 7 3.3|
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 4 1.8|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | 2 1 1 | 9 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 0| 8| 2| 8| 7| 6| 8| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Edema | | 1 2.0|
Inflammation, Suppurative | | 2 1.5|
Ulcer | | 1 1.0|
Mucosa, Hyperplasia | | 6 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Cyst | X X | 9 |
Edema | 2 | 1 2.0|
Erosion | | 1 1.0|
Inflammation, Subacute | | 1 2.0|
Metaplasia, Squamous | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Myocardium, Fibrosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X | 8 |
Cyst | | 1 |
Developmental Malformation | | 1 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Focal | | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 49 |
Hyperplasia | 2 | 8 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
Cyst | | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 48 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Hyperplasia | | 9 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | 3 1 3 | 25 1.9|
Inflammation, Subacute | | 1 1.0|
Follicle, Cyst | | 3 |
Follicular Cell, Hyperplasia | 1 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 0| 8| 2| 8| 7| 6| 8| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 48 |
Angiectasis | 2 4 | 10 2.9|
Cyst | | 16 |
Hemorrhage | | 1 4.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 7 2.3|
Hydrometra | 4 4 | 22 3.3|
Hyperplasia, Cystic | 2 4 2 2 2 2 1 3 3 2 | 56 2.2|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Suppurative | 2 4 | 4 3.0|
Metaplasia, Squamous | 3 | 3 1.7|
Myometrium, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | 2 4 | 9 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Iliac, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Iliac, Hemorrhage | 3 | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Iliac, Lymphatic, Dilatation | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 48 |
Hematopoietic Cell Proliferation | 4 | 3 3.0|
Hemorrhage | | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 0| 8| 2| 8| 7| 6| 8| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 49 |
Hematopoietic Cell Proliferation | 4 4 | 19 2.9|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 2 | 6 2.0|
Red Pulp, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + M + + + | 46 |
Angiectasis | | 5 2.4|
Cyst | X | 6 |
Depletion Cellular | 3 | 9 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Hyperplasia, Cystic | | 4 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | | 6 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Cyst | | 1 |
Hemorrhage | | 1 3.0|
Hydrocephalus | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | | 2 2.5|
Thalamus, Mineralization | 1 2 3 1 2 | 44 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 2 2.5|
Fibrosis | | 2 1.5|
Hemorrhage | 3 | 2 2.0|
Hyperplasia, Lymphoid | 2 1 | 15 1.4|
Infiltration Cellular, Histiocyte | | 5 3.0|
Leukocytosis | | 1 2.0|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
| 0| 8| 2| 8| 7| 6| 8| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | | 3 |
Glands, Hyperplasia, Cystic | 1 | 6 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 49 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
Cyst | | 1 |
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Casts Protein | 1 | 8 1.0|
Glomerulosclerosis | | 2 1.0|
Hemorrhage | | 1 2.0|
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 | 15 1.3|
Metaplasia, Osseous | | 2 1.5|
Mineralization | 1 1 | 13 1.2|
Interstitium, Pigmentation | | 2 1.0|
Renal Tubule, Atrophy | | 7 1.3|
Renal Tubule, Cytoplasmic Alteration | 3 | 1 3.0|
Renal Tubule, Dilatation | 1 | 4 2.0|
Renal Tubule, Necrosis | | 2 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | 1 1 2 1 | 38 1.4|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 49 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 | 23 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 9| 8| 1| 2| 0| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + | 1 |
Endometrium, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|
| 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.00700% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | X |
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 3 2 3 1 1 |
Hyperplasia, Lymphoid | 1 1 |
Inflammation, Subacute | 1 1 1 |
Mixed Cell Focus | X |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 4 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 2 |
Cyst | X |
Cytoplasmic Alteration | 4 3 |
Hyperplasia, Lymphoid | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Erosion | 4 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|
| 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.00700% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X |
Clear Cell Focus | X |
Hyperplasia, Focal | 3 1 1 |
Capsule, Hyperplasia | 3 |
X-Zone, Degeneration, Fatty | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 3 2 3 3 2 3 1 2 1 2 2 3 2 2|
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + I + + + + M + + + + + + + M + + + M +|
Angiectasis | 2 2 2 2 2 2|
Cyst | X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Hydrometra | 4 3 4 3 4 3 3 3 |
Hyperplasia, Cystic | 1 2 2 2 3 3 3 3 3 1 4 2 2 4 2 1 4 2 2 3 3 3 1 2|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|
| 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.00700% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + M + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
Lymphatic, Dilatation | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 2 3 |
Hemorrhage | |
Pigmentation, Hemosiderin | 2 2|
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 3 2 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X |
Depletion Cellular | 2 3 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Exudate | |
Inflammation, Chronic | |
Ulcer | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 3 2|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|
| 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.00700% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Inflammation, Chronic | |
Thalamus, Mineralization | 2 1 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 3 2 2 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 3 1 |
Hyperplasia, Lymphoid | 1 1 2 2 2 1 1 4|
Infiltration Cellular, Histiocyte | 2 4 2 4|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Glands, Hyperplasia, Cystic | 1 1 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 |
Cyst | X X X X |
Glomerulosclerosis | 1 1 |
Hemorrhage | |
Hydronephrosis | 1 |
Hyperplasia, Lymphoid | 2 1 1 1 1 2|
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 |
Interstitium, Pigmentation | 2 |
Renal Tubule, Atrophy | 3 3 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Regeneration | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Dilatation | 4 |
Edema | 3 |
Hyperplasia, Lymphoid | 3 1 1 1 3 1 1|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X 3 |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Focal | 3 3 2 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Subacute | 1 1 2 1 |
Mixed Cell Focus | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 2 |
Kupffer Cell, Pigmentation | 3 2 |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Cytoplasmic Alteration | 3 4 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 2 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Erosion | 3 |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Mucosa, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X|
Clear Cell Focus | X |
Hyperplasia, Focal | 3 |
Capsule, Hyperplasia | 2 2 |
X-Zone, Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 3 2 3 2 2 2|
Hyperplasia, Lymphoid | 2 1 |
Inflammation, Subacute | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 3 1 3 3 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | I + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 4 3 4|
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 4 3 2 3 4 4 2 4 2 2 |
Hyperplasia, Cystic | 2 3 2 2 2 2 3 1 2 2 2 2 1 2 2 3 3 2 2 3 2 2 2 2 2|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 |
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 3|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 4 4 3 3 2 1 |
Hemorrhage | 4 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 2|
Red Pulp, Hyperplasia | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X X |
Depletion Cellular | 3 4 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Exudate | X |
Inflammation, Chronic | 1 2 2 |
Ulcer | |
Subcutaneous Tissue, Edema | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
ANIMAL ID | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Thalamus, Mineralization | 2 2 2 3 1 1 2 1 2 2 2 3 2 1 2 2 3 1 1 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 3 1 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 |
Cyst | X X |
Glomerulosclerosis | 1 |
Hemorrhage | 2 |
Hydronephrosis | 1 |
Hyperplasia, Lymphoid | 1 1 2 3 1 1 1 1|
Metaplasia, Osseous | 2 |
Mineralization | 1 |
Interstitium, Pigmentation | |
Renal Tubule, Atrophy | 1 1 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Dilatation | 2 2 |
Renal Tubule, Regeneration | 1 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | |
Hyperplasia, Lymphoid | 1 1 1 1 3 1 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 4| 2| 4| 4| 4| | |
DAY ON TEST | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5| | |
| 3| 3| 2| 3| 4| 7| 1| 8| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + | 49 |
Cyst | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 51 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 51 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 2 3.0|
Clear Cell Focus | X | 4 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 2 3.5|
Hyperplasia, Focal | 3 | 11 2.3|
Hyperplasia, Lymphoid | | 3 1.3|
Inflammation, Subacute | 1 3 | 9 1.3|
Mixed Cell Focus | | 1 |
Centrilobular, Necrosis | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Hyperplasia | 2 3 | 5 2.6|
Kupffer Cell, Pigmentation | | 2 2.5|
Lobules, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Fat, Necrosis | 3 | 7 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Atrophy | | 1 2.0|
Cyst | | 1 |
Cytoplasmic Alteration | | 5 3.4|
Hyperplasia, Lymphoid | 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
Hyperplasia, Lymphoid | 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 4| 2| 4| 4| 4| | |
DAY ON TEST | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5| | |
| 3| 3| 2| 3| 4| 7| 1| 8| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 51 |
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 51 |
Cyst | | 13 |
Erosion | | 2 3.5|
Ulcer | | 1 3.0|
Mucosa, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
Myocardium, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Accessory Adrenal Cortical Nodule | X X | 18 |
Clear Cell Focus | | 2 |
Hyperplasia, Focal | | 4 2.0|
Capsule, Hyperplasia | | 3 2.3|
X-Zone, Degeneration, Fatty | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Hyperplasia | 1 2 | 5 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Pars Distalis, Angiectasis | | 2 1.5|
Pars Distalis, Hyperplasia | | 7 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 51 |
Degeneration, Cystic | 2 | 26 2.2|
Hyperplasia, Lymphoid | | 3 1.7|
Inflammation, Subacute | | 2 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 2 | 17 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 4| 2| 4| 4| 4| | |
DAY ON TEST | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5| | |
| 3| 3| 2| 3| 4| 7| 1| 8| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 46 |
Angiectasis | 2 4 | 15 2.6|
Cyst | X X | 14 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | 3 | 4 2.8|
Hydrometra | 2 | 19 3.1|
Hyperplasia, Cystic | 3 3 2 2 2 2 2 2 1 | 58 2.2|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 3 1.7|
Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 51 |
Hypercellularity | 3 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + | 49 |
Hyperplasia, Lymphoid | | 4 2.5|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + | 47 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 1 1 | 4 1.5|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | | 1 2.0|
Lymphatic, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 51 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 1 3 3 | 17 2.5|
Hemorrhage | | 1 4.0|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | | 6 2.2|
Red Pulp, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + I + + + | 49 |
Angiectasis | | 1 3.0|
Cyst | | 5 |
Depletion Cellular | 2 3 | 10 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 4| 2| 4| 4| 4| | |
DAY ON TEST | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5| | |
| 3| 3| 2| 3| 4| 7| 1| 8| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 3 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Acanthosis | | 3 2.7|
Exudate | | 1 |
Inflammation, Chronic | 1 | 4 1.5|
Ulcer | | 1 4.0|
Subcutaneous Tissue, Edema | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
Hyperostosis | | 7 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 51 |
Inflammation, Chronic | | 1 2.0|
Thalamus, Mineralization | 3 2 2 1 | 45 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 51 |
Congestion | 3 | 3 3.3|
Hemorrhage | 2 | 4 2.0|
Hyperplasia, Lymphoid | | 9 1.7|
Infiltration Cellular, Histiocyte | 3 | 7 2.7|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
Exudate | X | 5 |
Glands, Hyperplasia, Cystic | 2 | 7 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Hyperplasia, Focal | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Casts Protein | 1 | 10 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 4| 2| 4| 4| 4| | |
DAY ON TEST | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5| | |
| 3| 3| 2| 3| 4| 7| 1| 8| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | O |
B6C3F1 MICE FEMALE | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst | | 6 |
Glomerulosclerosis | | 3 1.0|
Hemorrhage | | 1 2.0|
Hydronephrosis | | 2 1.0|
Hyperplasia, Lymphoid | 2 | 15 1.4|
Metaplasia, Osseous | | 2 1.5|
Mineralization | | 6 1.0|
Interstitium, Pigmentation | | 1 2.0|
Renal Tubule, Atrophy | | 4 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
Renal Tubule, Dilatation | | 3 2.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 2 | 40 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Dilatation | | 1 4.0|
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 | 18 1.4|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|
| 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 3 3 2 2 3 2 3 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Inflammation, Chronic | 1|
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | 2 2 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | |
Mineralization | 3 |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 1 |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | X X |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia, Lymphoid | 1 2 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|
| 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Inflammation, Subacute | |
Metaplasia, Squamous | |
Mineralization | 2 |
Mucosa, Dysplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Dysplasia | 3 3 2 4 4 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | 1 |
Myocardium, Fibrosis | |
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X|
Basophilic Focus | X |
Clear Cell Focus | X |
Hyperplasia, Diffuse | 2 |
Hyperplasia, Focal | 1 3 2 1 2 2 1 2 1 1 2 1 2|
Hypertrophy, Focal | 3 |
Mineralization | 3 |
Capsule, Hyperplasia | 2 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 3 3 1 4 4 2 1 3 3 2 2 1 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 2 2 1 2 2 |
Follicle, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|
| 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + |
Dilatation | 3 3 3 3 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + |
Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 4 4 3 3 4 4 3 |
Fibrosis | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hypercellularity | 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + M + + + + + + + + + M + A + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | 3 2 2 1 2 1 2 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|
| 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 3 4 2 3 |
Lymphoid Follicle, Hyperplasia | 3|
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + + + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 2 3 3 2 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Thalamus, Mineralization | 1 3 3 2 3 1 1 3 1 1 2 2 2 3 2 1 2 3 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 1 2 |
Infiltration Cellular, Histiocyte | 3 2 2 3 3 4 3 4 3|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Artery, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X |
Glands, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 2 |
Cyst | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|
| 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 1 1 1 2 1 |
Inflammation, Chronic | |
Metaplasia, Osseous | 1 |
Mineralization | 3 3 2 3 3 2 2 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 3 3|
Renal Tubule, Atrophy | 1 2 2 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 2 3 3 3 3 2 3 2 2 3 2 3 2 3 2 2 2 3 2 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | 1 1 1|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 9| 3| 3| 6| 3| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 5|
| 7| 5| 7| 5| 6| 8| 8| 1| 8| 8| 1| 3| 1| 3| 3| 3| 1| 9| 6| 1| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + I + + + + + + + + + M + + M + + M + + M + + + +|
Dilatation | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +|
Diverticulum | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 3 2 3 3 3 3 3 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 3 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X |
Hepatocyte, Cytomegaly | 2 2 2 3 |
Hepatocyte, Karyomegaly | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 |
Kupffer Cell, Hyperplasia | 2 |
Lobules, Necrosis | 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 1 |
Mineralization | |
Fat, Necrosis | 4 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | 2 2 |
Focal Cellular Change | |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 1 2 1 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 9| 3| 3| 6| 3| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 5|
| 7| 5| 7| 5| 6| 8| 8| 1| 8| 8| 1| 3| 1| 3| 3| 3| 1| 9| 6| 1| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperkeratosis | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Inflammation, Subacute | 3 |
Metaplasia, Squamous | 1 |
Mineralization | 2 |
Mucosa, Dysplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + |
Dysplasia | 4 2 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | |
Myocardium, Fibrosis | 1 |
Myocardium, Inflammation, Chronic | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Basophilic Focus | X |
Clear Cell Focus | X |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 1 1 2 1 2 3 1 1 3 1 2 |
Hypertrophy, Focal | 3 |
Mineralization | |
Capsule, Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 3 3 2 3 3 3 3 2 4 4 3 1 2 1 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 |
Follicle, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 116
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 9| 3| 3| 6| 3| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 5|
| 7| 5| 7| 5| 6| 8| 8| 1| 8| 8| 1| 3| 1| 3| 3| 3| 1| 9| 6| 1| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 3 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
__________________________________________________________________________|
Preputial Gland | + + + |
Ectasia | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 3 3 2 4 3 |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Seminiferous Tubule, Atrophy | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | 2 3|
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 1 2 2 2 2 2 1 2 3 1 2 1 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 4 3 3 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 9| 3| 3| 6| 3| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 5|
| 7| 5| 7| 5| 6| 8| 8| 1| 8| 8| 1| 3| 1| 3| 3| 3| 1| 9| 6| 1| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 3 2 |
Lymphoid Follicle, Hyperplasia | 2 2 3 |
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + I + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 2 3 3 2 2|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Thalamus, Mineralization | 1 3 2 2 1 2 1 3 2 2 1 1 2 1 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 |
Infiltration Cellular, Histiocyte | 2 3 1 2 2 3 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 3 2 2 3 1 2 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X|
Glands, Hyperplasia, Cystic | 1 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 |
Cyst | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 9| 3| 3| 6| 3| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 5|
| 7| 5| 7| 5| 6| 8| 8| 1| 8| 8| 1| 3| 1| 3| 3| 3| 1| 9| 6| 1| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 1 1 2 1 |
Inflammation, Chronic | 1 1 |
Metaplasia, Osseous | 1 |
Mineralization | 2 2 1 3 3 3 2 2 3 3 2 2 2 2 2 3 3 3 2 2 2 3 3 3 2|
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | 1 1 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 2 2 3 3 2 2 2 2 3 3 2 3 2 2 2 3 1 3 1 1 2 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 0| 0| 6| 6| 7| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + | 53 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Diverticulum | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 3 |
Clear Cell Focus | | 11 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Focal | | 14 2.7|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 3 1.7|
Inflammation, Chronic Active | 1 | 2 1.0|
Mixed Cell Focus | | 1 |
Hepatocyte, Cytomegaly | 2 2 2 | 7 2.1|
Hepatocyte, Karyomegaly | | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 2 3 | 11 2.4|
Kupffer Cell, Hyperplasia | 3 | 4 2.3|
Lobules, Necrosis | | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Fibrosis | | 1 1.0|
Mineralization | | 1 3.0|
Fat, Necrosis | 2 | 6 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 6 2.0|
Cytoplasmic Alteration | 3 | 4 2.5|
Focal Cellular Change | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 0| 0| 6| 6| 7| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 1 1.0|
Hyperplasia, Lymphoid | 1 1 2 1 1 | 21 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | X | 13 |
Inflammation, Subacute | | 1 3.0|
Metaplasia, Squamous | | 1 1.0|
Mineralization | | 2 2.0|
Mucosa, Dysplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 17 |
Dysplasia | | 17 2.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Epicardium, Inflammation, Chronic | 1 | 2 1.0|
Myocardium, Fibrosis | | 1 1.0|
Myocardium, Inflammation, Chronic | | 3 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 3 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 3 |
Hyperplasia, Diffuse | | 1 2.0|
Hyperplasia, Focal | 2 2 1 2 1 1 | 31 1.6|
Hypertrophy, Focal | | 2 3.0|
Mineralization | | 1 3.0|
Capsule, Hyperplasia | 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 0| 0| 6| 6| 7| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 2 2 2 4 | 38 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M M + + + + + | 58 |
Pars Distalis, Angiectasis | 1 | 1 1.0|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 | 12 1.6|
Follicle, Inflammation, Suppurative | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 8 |
Dilatation | 4 | 8 3.3|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | I | 4 |
Ectasia | | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Chronic | 1 1 | 2 1.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 4 | 20 3.3|
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
Seminiferous Tubule, Atrophy | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hypercellularity | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 0| 0| 6| 6| 7| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 58 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Depletion Cellular | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 6 1.7|
Hemorrhage | 1 2 2 1 | 24 1.8|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 6 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 2 | 10 2.6|
Lymphoid Follicle, Hyperplasia | | 4 2.5|
Red Pulp, Atrophy | | 2 2.0|
Red Pulp, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 56 |
Cyst | X X | 10 |
Depletion Cellular | 2 | 11 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hydrocephalus | | 1 2.0|
Thalamus, Mineralization | 2 2 2 1 2 2 | 48 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 0| 0| 6| 6| 7| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Lymphoid | 1 | 6 1.3|
Infiltration Cellular, Histiocyte | 3 | 16 2.7|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 7 2.3|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 8 |
Glands, Hyperplasia, Cystic | | 6 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 1 1 | 11 1.1|
Cyst | | 28 |
Hydronephrosis | 3 | 3 2.3|
Hyperplasia, Lymphoid | 1 2 2 | 12 1.3|
Inflammation, Chronic | 1 1 | 4 1.0|
Metaplasia, Osseous | | 2 1.0|
Mineralization | 3 3 2 3 1 1 1 1 | 57 2.5|
Renal Tubule, Atrophy | | 4 1.8|
Renal Tubule, Dilatation | 1 1 1 1 | 7 1.0|
Renal Tubule, Necrosis | 3 | 1 3.0|
Renal Tubule, Regeneration | 3 2 2 2 2 1 2 1 2 1 | 55 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Hyperplasia, Lymphoid | | 4 1.0|
Inflammation, Chronic | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 9| 7| 1| 1| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 4| 4| 4| 4| 5| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 9| 7| 1| 1| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 4| 4| 4| 4| 5| | A |
VEHICLE | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3| 6| 3|
| 7| 6| 6| 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 7| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0200% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + I + + + + + + + + + +|
Cyst | X |
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Focal | 2 |
Hyperplasia, Lymphoid | |
Infarct | 3 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Mineralization | |
Mixed Cell Focus | X X X |
Centrilobular, Necrosis | 4 |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 |
Kupffer Cell, Hyperplasia | 3 2 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 3 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 3 2 |
Inflammation, Chronic | |
Acinar Cell, Dysplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3| 6| 3|
| 7| 6| 6| 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 7| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0200% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Subacute | |
Metaplasia, Squamous | |
Mineralization | 1 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Basophilic Focus | X X |
Clear Cell Focus | X |
Hyperplasia, Focal | 1 1 1 2 1 2 |
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 1 2 1 3 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 |
Inflammation, Subacute | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 128
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3| 6| 3|
| 7| 6| 6| 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 7| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0200% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + |
Ectasia | 4 3 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
Hemorrhage | 2 1 2 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 4 2 1 1 2|
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Depletion Cellular | 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 129
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3| 6| 3|
| 7| 6| 6| 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 7| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
0.0200% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 1 2 3 1 2 3 1 2 2 1 3 2 2 1 2 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 4 2 2 3|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 1 1 |
Cyst | X X X X X X X X|
Granuloma | |
Hyperplasia, Lymphoid | 1 1 2 2 |
Inflammation, Chronic | |
Mineralization | 2 3 3 2 3 3 2 3 2 2 3 2 1 3 1 3 3 2 2 3 3 2 3|
Renal Tubule, Atrophy | 1 1 3 1 3|
Renal Tubule, Dilatation | 1 2 2 3 2 2 1 1 2 2|
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Regeneration | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 3 1 2 2 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | 1 1 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 130
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 3| 6| 5| 7| 7| 6| 7| 7| 7| 2| 6| 3| 3| 3| 8| 5| 7| 7| 7| 1| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 3|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 3 3 |
Hyperplasia, Lymphoid | 3 |
Infarct | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | |
Mineralization | |
Mixed Cell Focus | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 2 3 2 |
Hepatocyte, Karyomegaly | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 4 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 |
Acinar Cell, Dysplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 131
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 3| 6| 5| 7| 7| 6| 7| 7| 7| 2| 6| 3| 3| 3| 8| 5| 7| 7| 7| 1| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Inflammation, Subacute | 2 |
Metaplasia, Squamous | 2 |
Mineralization | 1 2 1 1 |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Basophilic Focus | |
Clear Cell Focus | X X |
Hyperplasia, Focal | 3 1 1 2 1 1 1 1 3 2 1 1|
Hypertrophy, Focal | 3 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 2 3 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +|
Cyst | X X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2|
Inflammation, Subacute | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 132
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 3| 6| 5| 7| 7| 6| 7| 7| 7| 2| 6| 3| 3| 3| 8| 5| 7| 7| 7| 1| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + |
Ectasia | 2 3 3 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 1 1 3 1 1 3 1|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 1 2 2 2 2 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + + M + +|
Cyst | X X X X |
Depletion Cellular | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 133
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 3| 6| 5| 7| 7| 6| 7| 7| 7| 2| 6| 3| 3| 3| 8| 5| 7| 7| 7| 1| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 2 2 1 2 1 1 1 2 2 2 2 2 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 2 2 3 3 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 |
Cyst | X X X X X X X X |
Granuloma | 1|
Hyperplasia, Lymphoid | 2 1 1 2 1|
Inflammation, Chronic | 1 1 1 |
Mineralization | 3 2 2 3 1 1 2 2 2 3 2 2 1 2 1 2 3 3 3 2 2 3 2|
Renal Tubule, Atrophy | 2 2 3 2 3 2|
Renal Tubule, Dilatation | 1 2 1 2 2 2 2 2 2 1 |
Renal Tubule, Hyperplasia, Focal | 3 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Regeneration | 1 2 2 2 2 1 2 2 1 2 3 1 1 2 2 3 3 3 2 2 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 134
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 3| 6| 8| 7| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Cyst | | 1 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 5 |
Clear Cell Focus | | 4 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Focal | 2 3 | 5 2.6|
Hyperplasia, Lymphoid | | 1 3.0|
Infarct | | 1 3.0|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | 1 | 2 1.0|
Metaplasia, Osseous | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Mixed Cell Focus | | 3 |
Centrilobular, Necrosis | | 1 4.0|
Hepatocyte, Cytomegaly | 2 3 | 7 2.3|
Hepatocyte, Karyomegaly | 2 | 3 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 3 2 | 11 2.2|
Kupffer Cell, Hyperplasia | 3 | 4 2.5|
Kupffer Cell, Pigmentation | | 1 3.0|
Lobules, Necrosis | 3 | 6 2.3|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Cytoplasmic Alteration | | 2 2.5|
Inflammation, Chronic | | 1 1.0|
Acinar Cell, Dysplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 135
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 3| 6| 8| 7| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 | 13 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
Mucosa, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 10 |
Inflammation, Subacute | | 1 2.0|
Metaplasia, Squamous | | 1 2.0|
Mineralization | | 6 1.2|
__________________________________________________________________________|____________|
Tooth | | 3 |
Dysplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Myocardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 7 |
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Hyperplasia, Focal | 1 2 1 | 21 1.4|
Hypertrophy, Focal | | 1 3.0|
Capsule, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 3 3 | 18 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 | 12 1.1|
Inflammation, Subacute | 1 | 1 1.0|
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | 1 2 | 8 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 136
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 3| 6| 8| 7| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Dilatation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
Ectasia | | 7 2.9|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 2 3 | 8 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Seminiferous Tubule, Atrophy | | 4 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Hemorrhage | 3 2 | 13 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | 2 | 2 2.5|
Hematopoietic Cell Proliferation | | 11 2.0|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | | 1 3.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 137
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 3| 6| 8| 7| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X X | 9 |
Depletion Cellular | | 7 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Subcutaneous Tissue, Edema | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 2 1 2 2 2 | 47 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 3 1.7|
Infiltration Cellular, Histiocyte | | 8 2.6|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 4 |
Glands, Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | | 12 1.0|
Cyst | X X | 18 |
Granuloma | 2 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 138
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 3| 6| 8| 7| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| | A |
0.0200% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 1 1 | 12 1.3|
Inflammation, Chronic | | 3 1.0|
Mineralization | 3 2 3 2 2 1 2 1 3 2 | 56 2.3|
Renal Tubule, Atrophy | 1 2 | 13 2.0|
Renal Tubule, Dilatation | 2 2 2 2 1 2 2 1 | 28 1.8|
Renal Tubule, Hyperplasia, Focal | | 1 3.0|
Renal Tubule, Necrosis | | 2 2.0|
Renal Tubule, Regeneration | 2 2 2 1 2 2 1 2 1 | 57 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Hyperplasia, Lymphoid | 1 | 5 1.2|
Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 9| 7| 8| 2| 2| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + I + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Inflammation, Subacute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ectopic Thymus | X | 1 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 140
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 7| 9| 9| 7| 8| 2| 2| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | A |
0.0200% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 141
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 9| 9| 2| 1| 3| 8| 7| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 8| 9| 7| 8| 6| 1| 7| 7| 5| 5| 5| 5| 1| 5| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.0100% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 X X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 3 3 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Centrilobular, Necrosis | 1 |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 3 |
Kupffer Cell, Hyperplasia | 3 2 |
Kupffer Cell, Pigmentation | 3 1 |
Lobules, Necrosis | 1 1 1 2 |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | |
Cytoplasmic Alteration | 3 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
Inflammation, Subacute | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 142
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 9| 9| 2| 1| 3| 8| 7| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 8| 9| 7| 8| 6| 1| 7| 7| 5| 5| 5| 5| 1| 5| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.0100% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X|
Atrophy | |
Clear Cell Focus | X |
Developmental Malformation | |
Hyperplasia, Focal | 1 1 1 2 1 1 2 1 2 3 3 2 2 1 1 1|
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 4 2 1 2 3 2 3 1 2 1 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Degeneration, Cystic | 1 2 3 3 2 1 2 1 2 1 1|
Ectopic Thymus | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Dilatation | 4 4 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Ectasia | 3 3 2 3 3 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 143
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 9| 9| 2| 1| 3| 8| 7| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 8| 9| 7| 8| 6| 1| 7| 7| 5| 5| 5| 5| 1| 5| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.0100% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 3 4 2 2 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 1 1 1 2 3 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 3 1 2 2 1 3 |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 3 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X X |
Depletion Cellular | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 1 |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 1 1 2 1 1 2 1 1 2 3 1 2 2 1 2 3 2 2 3 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 144
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 9| 9| 2| 1| 3| 8| 7| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 8| 9| 7| 8| 6| 1| 7| 7| 5| 5| 5| 5| 1| 5| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
0.0100% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | 1 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 4 4|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Foreign Body | 1 |
Glands, Hyperplasia, Cystic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 2 |
Cyst | X X X X X X X X X X X X X |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 1 1 2 1|
Inflammation, Chronic | |
Metaplasia, Osseous | |
Mineralization | 2 2 3 2 1 1 2 3 2 3 2 3 2 2 1 1 1 3 2 3 2 2|
Renal Tubule, Atrophy | 2 3 2 |
Renal Tubule, Degeneration, Focal | |
Renal Tubule, Dilatation | 1 1 1 1 2 1 1 1 |
Renal Tubule, Hyperplasia, Focal | 2 2 |
Renal Tubule, Necrosis | 1|
Renal Tubule, Regeneration | 2 2 3 1 1 1 1 2 3 2 3 2 3 2 2 1 1 1 3 2 4 3 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Lymphoid | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 145
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 6| 3|
| 6| 5| 7| 5| 6| 8| 8| 2| 8| 8| 8| 8| 6| 6| 6| 1| 6| 3| 3| 3| 3| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 3 2 3 2 2 3 2 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X X |
Centrilobular, Necrosis | 2 |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 4 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 |
Cyst | X |
Cytoplasmic Alteration | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Inflammation, Subacute | 3 |
Mineralization | 2 1 |
_____________________________________________________________________________________________________________________|
Page 146
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 6| 3|
| 6| 5| 7| 5| 6| 8| 8| 2| 8| 8| 8| 8| 6| 6| 6| 1| 6| 3| 3| 3| 3| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Atrophy | 4 |
Clear Cell Focus | X X |
Developmental Malformation | X |
Hyperplasia, Focal | 1 1 2 1 2 1 2 2 3 1 2|
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 1 2 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1|
Ectopic Thymus | |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + +|
Dilatation | 3 4|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + |
Ectasia | 4 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 147
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 6| 3|
| 6| 5| 7| 5| 6| 8| 8| 2| 8| 8| 8| 8| 6| 6| 6| 1| 6| 3| 3| 3| 3| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 3 2 4 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 2 2 |
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 1 1 3 1 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + M + +|
Cyst | X |
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 1 1 2 1 2 2 2 1 1 2 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 148
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 6| 3|
| 6| 5| 7| 5| 6| 8| 8| 2| 8| 8| 8| 8| 6| 6| 6| 1| 6| 3| 3| 3| 3| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Embolus | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 1 2 4 3 3 3 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 2 1 1 1 3 3 1|
Cyst | X X X X X X X X X|
Hydronephrosis | |
Hyperplasia, Lymphoid | 1 1 2 1 2 1 1 1 1 3 2 |
Inflammation, Chronic | 2 |
Metaplasia, Osseous | |
Mineralization | 2 3 1 2 2 3 1 1 3 2 2 2 2 3 2 1 2 1 1 3 4 3|
Renal Tubule, Atrophy | 1 2 1 4 |
Renal Tubule, Degeneration, Focal | |
Renal Tubule, Dilatation | 1 1 1 2 2 2 2 1 1 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Regeneration | 1 3 1 1 2 3 3 2 2 2 1 3 2 1 1 1 1 1 2 1 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 149
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 0| 6| 6| 3| 8| 7| 7| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 52 |
Basophilic Focus | | 3 4.0|
Clear Cell Focus | X | 13 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 2 1 | 12 2.4|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mixed Cell Focus | | 3 |
Centrilobular, Necrosis | | 2 1.5|
Hepatocyte, Cytomegaly | 2 | 2 2.0|
Hepatocyte, Karyomegaly | 2 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 6 2.3|
Kupffer Cell, Hyperplasia | | 2 2.5|
Kupffer Cell, Pigmentation | | 2 2.0|
Lobules, Necrosis | 1 | 7 1.1|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemorrhage | | 1 4.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | 2 | 5 2.0|
Cyst | | 1 |
Cytoplasmic Alteration | | 2 3.0|
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | 2 2 | 15 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 150
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 0| 6| 6| 3| 8| 7| 7| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Cyst | | 8 |
Inflammation, Subacute | | 1 3.0|
Mineralization | | 3 1.3|
__________________________________________________________________________|____________|
Tooth | | 5 |
Dysplasia | | 5 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Epicardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X | 7 |
Atrophy | | 1 4.0|
Clear Cell Focus | | 3 |
Developmental Malformation | | 1 |
Hyperplasia, Focal | 1 1 1 1 | 31 1.5|
Hypertrophy, Focal | 3 | 1 3.0|
Capsule, Hyperplasia | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Atrophy | | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | 1 1 | 26 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Cyst | X | 6 |
Pars Distalis, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 49 |
Degeneration, Cystic | 2 1 | 15 1.6|
Ectopic Thymus | X | 1 |
Follicle, Cyst | X | 4 |
Follicular Cell, Hyperplasia | 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 151
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 0| 6| 6| 3| 8| 7| 7| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 5 |
Dilatation | | 5 3.8|
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Atypia Cellular | | 1 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Ectasia | | 6 3.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 51 |
Concretion | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Dilatation | 2 2 3 3 | 18 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Infarct | | 1 4.0|
Seminiferous Tubule, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Angiectasis | 1 | 1 1.0|
Hypercellularity | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | 1 | 12 1.7|
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + | 51 |
Hematopoietic Cell Proliferation | | 15 1.9|
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 2 2.5|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 46 |
Cyst | | 3 |
Depletion Cellular | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 152
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 0| 6| 6| 3| 8| 7| 7| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 1 1.0|
Hair Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Thalamus, Mineralization | 2 2 2 2 1 | 44 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 51 |
Embolus | | 1 1.0|
Hemorrhage | 1 | 4 1.5|
Hyperplasia, Lymphoid | | 2 1.5|
Infiltration Cellular, Histiocyte | | 9 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | | 1 |
Foreign Body | | 1 1.0|
Glands, Hyperplasia, Cystic | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 | 14 1.5|
Cyst | X X | 24 |
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | 1 1 1 | 18 1.3|
Inflammation, Chronic | 1 1 1 | 4 1.3|
Metaplasia, Osseous | 2 1 | 2 1.5|
Mineralization | 3 2 3 3 3 1 1 1 1 1 | 54 2.0|
Renal Tubule, Atrophy | 1 | 8 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 153
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 0| 6| 6| 3| 8| 7| 7| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0100% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Degeneration, Focal | 1 | 1 1.0|
Renal Tubule, Dilatation | 3 1 1 2 1 1 2 2 | 25 1.4|
Renal Tubule, Hyperplasia, Focal | | 2 2.0|
Renal Tubule, Necrosis | | 2 2.5|
Renal Tubule, Regeneration | 1 2 3 3 2 1 1 2 2 1 | 56 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Dilatation | | 1 3.0|
Hyperplasia, Lymphoid | | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 154
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 9| 9| 7| 8| 1| 0| 2| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 9| 0| 1| 1| 1| 1| 2| | A |
0.0100% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 155
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 5| 5| 3| 2| 3| 3| 3| 2| 2| 9| 2| 3| 3| 5| 3| 3| 3| 8| 3| 9| 8| 9| 5| 3|
| 8| 9| 9| 7| 7| 7| 5| 5| 8| 6| 0| 7| 4| 4| 8| 4| 4| 4| 6| 6| 8| 6| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0.00500% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X |
Hyperplasia, Focal | 1 2 3 3 3 2 3 2 2 3|
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | X |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | 1 2 |
Kupffer Cell, Pigmentation | 1 2 |
Lobules, Necrosis | 1 1 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 2 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Inflammation, Subacute | 1 |
Metaplasia, Squamous | 1 |
Mineralization | 2 1 |
Mucosa, Dysplasia | |
__________________________________________________________________________|
Tooth | + + + + + + |
Dysplasia | 3 3 2 2 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 156
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 5| 5| 3| 2| 3| 3| 3| 2| 2| 9| 2| 3| 3| 5| 3| 3| 3| 8| 3| 9| 8| 9| 5| 3|
| 8| 9| 9| 7| 7| 7| 5| 5| 8| 6| 0| 7| 4| 4| 8| 4| 4| 4| 6| 6| 8| 6| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0.00500% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hypertrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Clear Cell Focus | X X X |
Cyst | X |
Hyperplasia, Focal | 1 2 1 1 1 2 1 1 1 1|
Hypertrophy, Focal | 3 |
Capsule, Hyperplasia | 2 3 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 3 2 1 3 2 1 2 3 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 4 1 2 1 2 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + |
Dilatation | 3 4 3 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Ectasia | 4 4 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 157
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 5| 5| 3| 2| 3| 3| 3| 2| 2| 9| 2| 3| 3| 5| 3| 3| 3| 8| 3| 9| 8| 9| 5| 3|
| 8| 9| 9| 7| 7| 7| 5| 5| 8| 6| 0| 7| 4| 4| 8| 4| 4| 4| 6| 6| 8| 6| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0.00500% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 4 3 4 4 4 2 2 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
Seminiferous Tubule, Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation | 1 |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + I + + + + + + + + M +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 2 2 1 2 2 1 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 1 4 3 |
Pigmentation, Hemosiderin | 2 2 |
Lymphoid Follicle, Atrophy | 3 2 |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + + M + + + + + M M + +|
Cyst | X X|
Depletion Cellular | 2 2 3 4 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 158
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 5| 5| 3| 2| 3| 3| 3| 2| 2| 9| 2| 3| 3| 5| 3| 3| 3| 8| 3| 9| 8| 9| 5| 3|
| 8| 9| 9| 7| 7| 7| 5| 5| 8| 6| 0| 7| 4| 4| 8| 4| 4| 4| 6| 6| 8| 6| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0.00500% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 3 1 2 2 2 1 1 1 1 2 2 2 3 2 3 2 3 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 4 3 4 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 2 2 1 1 1 3 1 2 1 1 4 |
Cyst | X X X X X X X X X X X X X X |
Glomerulosclerosis | 1 1 |
Granuloma | 1 |
Hydronephrosis | 2 2 |
Hyperplasia, Lymphoid | 3 3 1 3 3 2 2 1|
Inflammation, Chronic | |
Metaplasia, Osseous | 2 |
Mineralization | 1 3 1 3 1 3 3 3 3 3 3 2 2 3 2 1 2 3 1 1 2|
Renal Tubule, Atrophy | 2 2 2 3 2 2 4 2|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Focal | 3 |
Renal Tubule, Regeneration | 1 3 2 4 2 2 2 2 2 2 2 2 2 3 2 2 4 2 3 1 3 2 2|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 1 |
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 159
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 3| 0| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 5| 1| 2| 2| 8| 6| 5| 2| 6| 6| 6| 6| 6| 7| 7| 1| 1| 1| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X|
Hyperplasia, Focal | 3 2 3 3 3 3 3 3 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 1 |
Mixed Cell Focus | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + M + + + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + M + + + + + +|
Edema | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + M + + + + + M + + + + + +|
Cyst | X X X X |
Inflammation, Subacute | 3|
Metaplasia, Squamous | |
Mineralization | 1 |
Mucosa, Dysplasia | 3|
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 160
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 3| 0| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 5| 1| 2| 2| 8| 6| 5| 2| 6| 6| 6| 6| 6| 7| 7| 1| 1| 1| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hypertrophy | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Clear Cell Focus | X X X X|
Cyst | |
Hyperplasia, Focal | 1 1 2 2 2 1 1 1 1 1 1|
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 3 1 2 2 2 1 1 2 1 2 3 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + M I + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + +|
Degeneration, Cystic | 2 2 2 3 2 1 2|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + |
Dilatation | 4 4 4 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 1 2 |
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Ectasia | 3 4 2 4 3|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 161
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 3| 0| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 5| 1| 2| 2| 8| 6| 5| 2| 6| 6| 6| 6| 6| 7| 7| 1| 1| 1| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 2 4 3 4 4 4 4 3 3|
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Seminiferous Tubule, Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | 1 3 2 1 1 3 |
Hyperplasia, Lymphoid | 2 4|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 1 3 1 1 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + M + + + + M +|
Cyst | X X |
Depletion Cellular | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 162
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 3| 0| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 5| 1| 2| 2| 8| 6| 5| 2| 6| 6| 6| 6| 6| 7| 7| 1| 1| 1| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 2 2 1 2 2 1 2 1 1 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 |
Infiltration Cellular, Histiocyte | 4 3 2 4 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 2 1 2 3 |
Cyst | X X X X X X X X|
Glomerulosclerosis | |
Granuloma | |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 1 2 1 1 1 1 1 1 2 |
Inflammation, Chronic | 1 1 |
Metaplasia, Osseous | |
Mineralization | 3 3 2 1 2 2 2 2 2 1 3 3 3 1 2 2 2 2 2 2 2 2 2|
Renal Tubule, Atrophy | 2 1 1 2 3 3 1|
Renal Tubule, Dilatation | 1 1 1 1 2 1 2 2 1 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 1 3 2 1 2 2 1 1 2 1 2 2 1 2 3 3 1 1 1 1 3 1 2 3 3|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 163
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 5| 3| 1| 3| 6| 8| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 51 |
Basophilic Focus | 3 X | 4 3.0|
Clear Cell Focus | X X | 11 |
Hyperplasia, Focal | 4 2 | 21 2.7|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic | | 2 1.5|
Mixed Cell Focus | | 1 |
Centrilobular, Necrosis | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 2 2.0|
Kupffer Cell, Hyperplasia | | 3 2.0|
Kupffer Cell, Pigmentation | | 3 2.0|
Lobules, Necrosis | 4 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | 1 | 13 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 48 |
Edema | | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 48 |
Cyst | X X | 11 |
Inflammation, Subacute | | 2 2.0|
Metaplasia, Squamous | | 1 1.0|
Mineralization | 2 1 | 5 1.4|
Mucosa, Dysplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 164
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 5| 3| 1| 3| 6| 8| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + | 11 |
Dysplasia | 3 3 | 11 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Hypertrophy | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Myocardium, Mineralization | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | | 4 |
Clear Cell Focus | | 7 |
Cyst | | 1 |
Hyperplasia, Focal | 2 1 3 | 24 1.3|
Hypertrophy, Focal | | 1 3.0|
Capsule, Hyperplasia | 2 | 11 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Cyst | | 1 |
Hyperplasia | 1 2 1 | 27 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M | 47 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 45 |
Pars Distalis, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 49 |
Degeneration, Cystic | 2 | 17 1.8|
Follicle, Cyst | X X | 3 |
Follicular Cell, Hyperplasia | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 8 |
Dilatation | | 8 3.6|
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 165
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 5| 3| 1| 3| 6| 8| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atypia Cellular | | 2 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 2 1.5|
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 10 |
Ectasia | 4 | 9 3.6|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 51 |
Dilatation | 3 | 19 3.3|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Congestion | | 1 3.0|
Hemorrhage | | 1 3.0|
Seminiferous Tubule, Atrophy | | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Angiectasis | | 1 2.0|
Hypercellularity | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 46 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Hematopoietic Cell Proliferation | | 3 1.3|
Hemorrhage | 2 1 | 15 1.7|
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Angiectasis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 13 2.2|
Pigmentation, Hemosiderin | | 2 2.0|
Lymphoid Follicle, Atrophy | | 2 2.5|
Lymphoid Follicle, Hyperplasia | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 166
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 5| 3| 1| 3| 6| 8| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + | 41 |
Cyst | X | 5 |
Depletion Cellular | 3 | 9 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Acanthosis | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Thalamus, Mineralization | 2 1 1 2 | 38 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 53 |
Congestion | | 1 3.0|
Hemorrhage | 1 | 3 1.3|
Hyperplasia, Lymphoid | 1 | 4 1.3|
Infiltration Cellular, Histiocyte | | 9 3.1|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | X | 5 |
Glands, Hyperplasia, Cystic | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 | 18 1.7|
Cyst | X X | 24 |
Glomerulosclerosis | | 2 1.0|
Granuloma | | 1 1.0|
Hydronephrosis | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 167
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 8| 3| 3| 5| 5| 5| 5| 5| | |
| 5| 3| 1| 3| 6| 8| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| | A |
0.00500% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 | 18 1.7|
Inflammation, Chronic | 2 | 3 1.3|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 2 3 2 3 2 1 1 1 1 2 | 54 2.1|
Renal Tubule, Atrophy | 2 2 | 17 2.1|
Renal Tubule, Dilatation | 1 1 2 1 1 | 14 1.3|
Renal Tubule, Hyperplasia, Focal | | 1 3.0|
Renal Tubule, Regeneration | 1 2 1 2 2 1 3 2 2 1 | 58 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 51 |
Dilatation | | 1 4.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 4 1.0|
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 168
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 8| 3| 3| 3| 3|
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 2| 6| 0| 6| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0.0275% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Focal | 3 3 3 2 3 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Bile Duct, Cyst | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 1 3 |
Lobules, Necrosis | 1 1 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 1 2 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 1 2|
Edema | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Edema | 2 |
Inflammation, Subacute | 3 2 |
_____________________________________________________________________________________________________________________|
Page 169
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 8| 3| 3| 3| 3|
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 2| 6| 0| 6| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0.0275% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Metaplasia, Squamous | 1 |
Mineralization | 1 |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + + |
Dysplasia | 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | |
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X|
Clear Cell Focus | X X X X |
Hyperplasia, Focal | 2 1 2 3 1 1 1 1 1 2 2 1 2 1 3 1 1 1 3|
Capsule, Hyperplasia, Focal | 3 |
Capsule, Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hyperplasia, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 4 1 2 3 3 2 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 2 2 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 4 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
_____________________________________________________________________________________________________________________|
Page 170
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 8| 3| 3| 3| 3|
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 2| 6| 0| 6| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0.0275% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Ectasia | 3 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 2 3 4 2 2 3 3 4 |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hypercellularity | 3 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 1 3 1 2 1 2 1 2 |
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Hematopoietic Cell Proliferation | 3 3 3 2 |
Red Pulp, Atrophy | 2 |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Depletion Cellular | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fat, Necrosis | |
Subcutaneous Tissue, Fibrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 171
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 8| 3| 3| 3| 3|
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 2| 6| 0| 6| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0.0275% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Thalamus, Mineralization | 2 2 3 2 1 2 2 2 2 2 2 2 2 3 2 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 2 |
Infiltration Cellular, Histiocyte | 4 4 2 3|
Inflammation, Chronic | |
Leukocytosis | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 |
Cyst | X X X X X X X X X X X|
Glomerulosclerosis | |
Granuloma | 1 1 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 1 1 2 1 1 2 1 1|
Inflammation, Chronic | |
Metaplasia, Osseous | 2 |
Mineralization | 2 2 2 2 3 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 1 3 3 3 2|
Renal Tubule, Atrophy | 1 1 |
Renal Tubule, Dilatation | 3 1 1 1 1 2 1 1 2 1 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 2 1 2 2 2 2 3 1 3 3 3 3 2 1 3 3 2 2 1 3 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 172
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 0| 4| 4| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6|
DAY ON TEST | 5| 2| 5| 5| 5| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 9| 6| 8| 3| 3| 8|
| 6| 6| 5| 7| 7| 7| 7| 7| 2| 1| 7| 1| 3| 1| 3| 3| 1| 8| 8| 1| 5| 5| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + I + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 3 2 3 3 3|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Bile Duct, Cyst | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Karyomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 |
Cytoplasmic Alteration | |
Focal Cellular Change | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +|
Diverticulum | |
Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X |
Edema | |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 173
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 0| 4| 4| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6|
DAY ON TEST | 5| 2| 5| 5| 5| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 9| 6| 8| 3| 3| 8|
| 6| 6| 5| 7| 7| 7| 7| 7| 2| 1| 7| 1| 3| 1| 3| 3| 1| 8| 8| 1| 5| 5| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Metaplasia, Squamous | |
Mineralization | |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | 2 |
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Clear Cell Focus | X X X X |
Hyperplasia, Focal | 2 1 3 2 3 2 1 1 3 1 |
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia | 2 2 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 4 1 1 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 1 1 |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 3 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
_____________________________________________________________________________________________________________________|
Page 174
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 0| 4| 4| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6|
DAY ON TEST | 5| 2| 5| 5| 5| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 9| 6| 8| 3| 3| 8|
| 6| 6| 5| 7| 7| 7| 7| 7| 2| 1| 7| 1| 3| 1| 3| 3| 1| 8| 8| 1| 5| 5| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Ectasia | 2 4 4 2 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 2 |
Fibrosis | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 1 1 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Congestion | |
Hematopoietic Cell Proliferation | 3 3 2 3 1|
Red Pulp, Atrophy | |
Red Pulp, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | X X X X X |
Depletion Cellular | 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fat, Necrosis | 2 |
Subcutaneous Tissue, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 175
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 0| 4| 4| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6|
DAY ON TEST | 5| 2| 5| 5| 5| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 9| 6| 8| 3| 3| 8|
| 6| 6| 5| 7| 7| 7| 7| 7| 2| 1| 7| 1| 3| 1| 3| 3| 1| 8| 8| 1| 5| 5| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Thalamus, Mineralization | 1 2 2 2 1 1 2 1 1 2 1 2 2 1 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 4 4 |
Inflammation, Chronic | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 3 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 2 3 |
Cyst | X X X X X X X X X X X X X |
Glomerulosclerosis | 1|
Granuloma | 1 1 |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 2 2 1 1 1 1 1 1 2|
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Mineralization | 1 1 2 2 3 1 3 1 1 3 1 2 2 2 2 2 2 3 |
Renal Tubule, Atrophy | 1 1 2 3|
Renal Tubule, Dilatation | 1 1 2 2 2 1 1 2 1 1 3|
Renal Tubule, Hyperplasia, Focal | 3 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 2 2 2 2 1 2 2 3 2 3 3 2 2 2 2 1 1 4 2 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Lymphoid | 2 1 1|
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 176
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 8| 7| 5| 8| 5| 5| 5| 5| 5| | |
| 6| 8| 5| 8| 4| 8| 6| 7| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + I + + I + + + + + | 56 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 4 |
Clear Cell Focus | X | 8 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Focal | 2 | 13 2.7|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Bile Duct, Cyst | X | 1 |
Centrilobular, Necrosis | 4 | 1 4.0|
Hepatocyte, Cytomegaly | 2 | 2 2.0|
Hepatocyte, Karyomegaly | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 | 6 2.0|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 2 | 3 2.0|
Lobules, Necrosis | 4 1 | 5 2.2|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 4 1.3|
Cytoplasmic Alteration | 3 | 2 3.0|
Focal Cellular Change | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 1 1 1 | 19 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Diverticulum | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 177
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 8| 7| 5| 8| 5| 5| 5| 5| 5| | |
| 6| 8| 5| 8| 4| 8| 6| 7| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst | X | 8 |
Edema | | 1 2.0|
Inflammation, Subacute | 2 | 4 2.3|
Metaplasia, Squamous | | 1 1.0|
Mineralization | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 7 |
Dysplasia | | 6 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Epicardium, Inflammation, Chronic | | 1 2.0|
Myocardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 5 |
Clear Cell Focus | X | 9 |
Hyperplasia, Focal | 2 2 | 31 1.7|
Capsule, Hyperplasia, Focal | | 1 3.0|
Capsule, Hyperplasia | 2 | 10 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 3 3 | 24 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 | 5 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 2 2 | 16 1.6|
Follicle, Cyst | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 178
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 8| 7| 5| 8| 5| 5| 5| 5| 5| | |
| 6| 8| 5| 8| 4| 8| 6| 7| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 4 |
Dilatation | | 4 3.8|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | | 1 |
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
Ectasia | | 6 3.0|
Inflammation, Chronic | | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 14 2.9|
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
Seminiferous Tubule, Atrophy | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hypercellularity | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 1 3 2 1 | 17 1.6|
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Congestion | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 | 11 2.5|
Red Pulp, Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 179
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 8| 7| 5| 8| 5| 5| 5| 5| 5| | |
| 6| 8| 5| 8| 4| 8| 6| 7| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Red Pulp, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Cyst | X | 10 |
Depletion Cellular | 2 | 8 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Fat, Necrosis | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Metaplasia, Osseous | | 1 1.0|
Thalamus, Mineralization | 2 1 2 1 1 2 1 2 | 48 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 2 | 3 2.7|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 2 1.5|
Infiltration Cellular, Histiocyte | 2 | 7 3.3|
Inflammation, Chronic | 1 | 1 1.0|
Leukocytosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 |
Glands, Hyperplasia, Cystic | | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 180
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 8| 7| 5| 8| 5| 5| 5| 5| 5| | |
| 6| 8| 5| 8| 4| 8| 6| 7| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | | 11 1.3|
Cyst | X X | 26 |
Glomerulosclerosis | | 1 1.0|
Granuloma | | 4 1.0|
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | 1 | 18 1.3|
Inflammation, Chronic | 1 | 2 1.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 1 1 2 2 | 48 2.2|
Renal Tubule, Atrophy | 1 | 7 1.4|
Renal Tubule, Dilatation | 1 1 1 1 2 1 1 1 | 29 1.4|
Renal Tubule, Hyperplasia, Focal | 2 | 2 2.5|
Renal Tubule, Pigmentation | 2 | 1 2.0|
Renal Tubule, Regeneration | 2 1 1 2 1 2 2 1 | 53 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 3 3.7|
Hyperplasia, Lymphoid | 2 | 5 1.4|
Inflammation, Chronic | 1 1 | 2 1.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 181
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 8| 7| 1| 2| 2| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + I + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + I + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 182
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 7| 9| 8| 7| 1| 2| 2| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| | A |
0.0275% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + M + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 183
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 8| 5| 3| 3| 2| 5| 9| 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 5| 3| 3| 3| 2| 3| 6|
| 0| 1| 3| 3| 6| 1| 8| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 5| 8| 4| 4| 4| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
0.0140% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X X X X X X X |
Hemorrhage | 1 |
Hyperplasia, Focal | 2 3 2 3 3 2 3 3 3 2 2 1 2|
Inflammation, Chronic | 3 1 |
Mineralization | |
Mixed Cell Focus | |
Centrilobular, Necrosis | 3 3|
Hepatocyte, Cytomegaly | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Fungus | |
Fat, Inflammation, Pyogranulomatous | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Erosion | 3 |
Inflammation, Subacute | 2 2 |
Mineralization | 1 1 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + |
Dysplasia | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 184
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 8| 5| 3| 3| 2| 5| 9| 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 5| 3| 3| 3| 2| 3| 6|
| 0| 1| 3| 3| 6| 1| 8| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 5| 8| 4| 4| 4| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
0.0140% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Basophilic Focus | X |
Clear Cell Focus | X X X|
Cyst | X |
Developmental Malformation | X X |
Hyperplasia, Focal | 2 2 2 1 2 2 2 1 1 2 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 2 2 1 3 1 3 1 1 3 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + I M + + + + + + + + + M + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 2 2 2 1|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Ectasia | 2 3 3 2 3 4 3 3 3 3 3 4 |
Inflammation, Chronic | 2 3 2 2 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 185
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 8| 5| 3| 3| 2| 5| 9| 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 5| 3| 3| 3| 2| 3| 6|
| 0| 1| 3| 3| 6| 1| 8| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 5| 8| 4| 4| 4| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
0.0140% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 4 4 3 3 3 4 4 3 |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + I + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1|
Hemorrhage | 2 1 3 1 2 1 1|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | M + + + M M + + + M + + + + + + + + + + + + + + +|
Cyst | X X |
Depletion Cellular | 2 3 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Ulcer | 3 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 1 3 2 2 2 2 1 1 1 2 2 3 1 1 3 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 3 1 |
_____________________________________________________________________________________________________________________|
Page 186
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 8| 5| 3| 3| 2| 5| 9| 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 5| 3| 3| 3| 2| 3| 6|
| 0| 1| 3| 3| 6| 1| 8| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 5| 8| 4| 4| 4| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
0.0140% | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 1 |
Infiltration Cellular, Histiocyte | 4 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 3 3 2 |
Cyst | X X X X X X X X X X |
Glomerulosclerosis | 1 2 2 |
Granuloma | 2 |
Hydronephrosis | 2 2 2 |
Hyperplasia, Lymphoid | 1 3 1 1 3 1 1 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Mineralization | 2 3 3 3 2 2 3 2 3 3 3 2 2 3 2 2 3 2 2 1 1|
Renal Tubule, Atrophy | 1 2 2 2 2 1 |
Renal Tubule, Dilatation | 1 2 1 1 |
Renal Tubule, Regeneration | 1 1 2 3 2 1 2 1 2 1 2 3 1 3 1 2 2 2 3 3 3 2 1 2 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 187
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 7| 5| 6| 8| 8| 7| 7| 8| 1| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 0| 1| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X |
Hemorrhage | |
Hyperplasia, Focal | 2 4 2 3 2 3 3 |
Inflammation, Chronic | 3 |
Mineralization | 2 |
Mixed Cell Focus | X |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 3 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Fungus | |
Fat, Inflammation, Pyogranulomatous | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Erosion | |
Inflammation, Subacute | |
Mineralization | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 2 |
_____________________________________________________________________________________________________________________|
Page 188
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 7| 5| 6| 8| 8| 7| 7| 8| 1| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 0| 1| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Basophilic Focus | |
Clear Cell Focus | X X X |
Cyst | |
Developmental Malformation | |
Hyperplasia, Focal | 1 2 1 1 1 3 2 2 3 1 2 2 2 3 1|
Capsule, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 1 4 3 3 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + +|
Dilatation | 3 4 4 3|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Ectasia | 3 4 4 3 |
Inflammation, Chronic | 2 3 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 189
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 7| 5| 6| 8| 8| 7| 7| 8| 1| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 0| 1| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 3 4 3 3 3 3 4 2 4 2 3|
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 2 2 1 2 2 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 2 1 |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 2 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 2 2 3 2 1 2 1 1 2 1 2 2 1 3 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 190
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 7| 5| 6| 8| 8| 7| 7| 8| 1| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 0| 1| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 1 1 |
Infiltration Cellular, Histiocyte | 3 4 2 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Glands, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 3 1 1 |
Cyst | X X X X X X X X X X X X|
Glomerulosclerosis | 1 |
Granuloma | 1 |
Hydronephrosis | 2 2 |
Hyperplasia, Lymphoid | 1 2 1 1 3 1 1 |
Inflammation, Chronic | 1 3 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Mineralization | 1 2 3 1 3 2 3 2 3 2 2 3 3 3 2 2 3 2 2 2 3 3 2 3|
Renal Tubule, Atrophy | 1 1 2 3 |
Renal Tubule, Dilatation | 1 1 1 2 1 |
Renal Tubule, Regeneration | 2 2 2 3 2 1 2 2 2 2 3 2 2 2 3 2 2 3 2 2 2 2 1 2 3|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 191
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| | |
| 3| 3| 2| 0| 8| 7| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 48 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 55 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 3 |
Clear Cell Focus | X | 16 |
Hemorrhage | | 1 1.0|
Hyperplasia, Focal | 2 3 2 | 23 2.5|
Inflammation, Chronic | | 3 2.3|
Mineralization | | 1 2.0|
Mixed Cell Focus | | 1 |
Centrilobular, Necrosis | | 2 3.0|
Hepatocyte, Cytomegaly | | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 6 2.5|
Kupffer Cell, Pigmentation | | 1 2.0|
Lobules, Necrosis | 3 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Fungus | X | 1 |
Fat, Inflammation, Pyogranulomatous | 4 | 1 4.0|
Fat, Necrosis | 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 51 |
Atrophy | | 4 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | | 13 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Cyst | | 6 |
Erosion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 192
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| | |
| 3| 3| 2| 0| 8| 7| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Subacute | 3 | 3 2.3|
Mineralization | | 4 1.3|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 6 |
Dysplasia | | 5 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Myocardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | | 6 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 6 |
Cyst | | 1 |
Developmental Malformation | | 2 |
Hyperplasia, Focal | 2 | 26 1.8|
Capsule, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | 2 2 | 29 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M | 45 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Cyst | X | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | 2 3 | 13 1.8|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 6 |
Dilatation | | 5 3.4|
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 193
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| | |
| 3| 3| 2| 0| 8| 7| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Fibrosis | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 20 |
Ectasia | 3 3 | 18 3.1|
Inflammation, Chronic | | 9 2.3|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 51 |
Dilatation | 2 | 22 3.2|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 1 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 6 1.5|
Hemorrhage | 1 1 | 16 1.6|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 51 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 8 2.1|
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 4 2.0|
Red Pulp, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 46 |
Cyst | | 4 |
Depletion Cellular | 3 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 194
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| | |
| 3| 3| 2| 0| 8| 7| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 1 4.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Thalamus, Mineralization | 3 2 3 1 2 | 43 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 52 |
Congestion | | 2 2.0|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | | 5 1.6|
Infiltration Cellular, Histiocyte | | 6 3.2|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | | 2 |
Glands, Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 3 1 | 12 1.9|
Cyst | X | 23 |
Glomerulosclerosis | | 4 1.5|
Granuloma | | 2 1.5|
Hydronephrosis | | 5 2.0|
Hyperplasia, Lymphoid | 1 | 15 1.5|
Inflammation, Chronic | 1 1 | 5 1.4|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 2 3 2 1 1 1 1 1 2 | 54 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 195
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| | |
| 3| 3| 2| 0| 8| 7| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| | A |
0.0140% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Atrophy | 3 | 11 1.8|
Renal Tubule, Dilatation | 1 1 1 1 2 | 14 1.2|
Renal Tubule, Regeneration | 2 3 1 3 1 1 2 3 2 | 59 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 196
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 9| 7| 9| 8| 7| 1| 2| 0| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | A |
0.0140% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 197
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 2| 3| 0| 4| 2| 3| 6| 3| 3| 3| 2| 3| 3| 9| 7| 3| 9| 2| 2| 1| 3| 3|
| 8| 6| 6| 7| 6| 1| 8| 6| 7| 8| 7| 7| 5| 7| 5| 5| 9| 7| 3| 0| 2| 7| 4| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.00700% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X|
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 3 3 3 3 2 1 |
Inflammation, Chronic | |
Mixed Cell Focus | X |
Centrilobular, Necrosis | |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | 2 2 2 3 |
Lobules, Necrosis | 1 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | X |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1|
Cytoplasmic Alteration | 4 |
Focal Cellular Change | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 2 1 2 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Ulcer | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Erosion | 2 3 2 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
Page 198
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 2| 3| 0| 4| 2| 3| 6| 3| 3| 3| 2| 3| 3| 9| 7| 3| 9| 2| 2| 1| 3| 3|
| 8| 6| 6| 7| 6| 1| 8| 6| 7| 8| 7| 7| 5| 7| 5| 5| 9| 7| 3| 0| 2| 7| 4| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.00700% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | 3 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X|
Basophilic Focus | |
Clear Cell Focus | X X X X X |
Hyperplasia, Focal | 1 2 3 1 2 2 1 1 1 1 1 |
Hypertrophy, Focal | 4 |
Capsule, Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 1 3 4 1 2 2 1 3 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 2 2 1 1 1 |
Inflammation, Subacute | 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + |
Dilatation | 2 4 3 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + |
Ectasia | 3 4 4 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 2 4 3 2 4 3 3 4 4 |
Fibrosis | |
Hemorrhage | 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 199
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 2| 3| 0| 4| 2| 3| 6| 3| 3| 3| 2| 3| 3| 9| 7| 3| 9| 2| 2| 1| 3| 3|
| 8| 6| 6| 7| 6| 1| 8| 6| 7| 8| 7| 7| 5| 7| 5| 5| 9| 7| 3| 0| 2| 7| 4| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.00700% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | 1 1 1 1 2 1 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 4 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 2 3 2 1|
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Atrophy | 3 3 |
Lymphoid Follicle, Hyperplasia | 2 |
Red Pulp, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + M + + + M M|
Cyst | X X |
Depletion Cellular | 3 2 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 3 |
Thalamus, Mineralization | 1 1 2 2 1 2 2 2 2 2 1 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 200
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 2| 3| 0| 4| 2| 3| 6| 3| 3| 3| 2| 3| 3| 9| 7| 3| 9| 2| 2| 1| 3| 3|
| 8| 6| 6| 7| 6| 1| 8| 6| 7| 8| 7| 7| 5| 7| 5| 5| 9| 7| 3| 0| 2| 7| 4| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.00700% | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 2 |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Glands, Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 2 |
Cyst | X X X X X X X X X X X X X |
Granuloma | |
Hyperplasia, Lymphoid | 1 1 2 |
Inflammation, Chronic | |
Metaplasia, Osseous | 3|
Mineralization | 3 2 2 2 2 3 1 3 2 2 2 2 3 3 3 3 1 2 2 4 2 3|
Pigmentation, Cholesterol | 2 |
Papilla, Necrosis | |
Renal Tubule, Atrophy | 1 1 1 2 2 1 2 |
Renal Tubule, Dilatation | 1 1 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Regeneration | 1 3 2 2 2 1 1 3 1 2 3 1 1 3 3 2 2 1 2 4 3|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 201
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 8| 3| 4| 3| 3| 6| 2| 8| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 6| 8| 2| 7| 0| 7| 7| 2| 3| 8| 2| 7| 7| 3| 6| 3| 3| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X|
Clear Cell Focus | X X X X X|
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 3 3 2 3 3 3 3 3 3 2 |
Inflammation, Chronic | 3 1 |
Mixed Cell Focus | X |
Centrilobular, Necrosis | 3 |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3|
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 4 4 2 3 4 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
Cytoplasmic Alteration | |
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Erosion | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + M |
_____________________________________________________________________________________________________________________|
Page 202
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 8| 3| 4| 3| 3| 6| 2| 8| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 6| 8| 2| 7| 0| 7| 7| 2| 3| 8| 2| 7| 7| 3| 6| 3| 3| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Basophilic Focus | X |
Clear Cell Focus | X |
Hyperplasia, Focal | 2 1 1 2 2 1 3 |
Hypertrophy, Focal | |
Capsule, Hyperplasia | 2 3 3 3 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 3 1 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 1 3 2 1 |
Inflammation, Subacute | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | M + |
Dilatation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Ectasia | 3 3 3 3 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 2 4 3 2 3 4 3 |
Fibrosis | 2 |
Hemorrhage | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 203
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 8| 3| 4| 3| 3| 6| 2| 8| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 6| 8| 2| 7| 0| 7| 7| 2| 3| 8| 2| 7| 7| 3| 6| 3| 3| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + I + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M +|
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | 3 1 2 2 3 3 1 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 3 2 4 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + I +|
Cyst | X X X X|
Depletion Cellular | 2 2 3 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Thalamus, Mineralization | 2 2 2 1 2 2 1 1 3 3 3 3 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 204
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 8| 3| 4| 3| 3| 6| 2| 8| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 6| 7| 5| 7| 6| 8| 2| 7| 0| 7| 7| 2| 3| 8| 2| 7| 7| 3| 6| 3| 3| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 3 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X|
Glands, Hyperplasia, Cystic | 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Suppurative | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 1 1 |
Cyst | X X X X X X X X|
Granuloma | 1 |
Hyperplasia, Lymphoid | 1 1 1 3 1|
Inflammation, Chronic | |
Metaplasia, Osseous | |
Mineralization | 1 2 2 2 2 2 2 2 3 2 2 3 2 2 3 3 3 3 2 2 1 1 2 3|
Pigmentation, Cholesterol | |
Papilla, Necrosis | |
Renal Tubule, Atrophy | 1 1 2 2 1 |
Renal Tubule, Dilatation | 1 1 1 1 1 3 1 |
Renal Tubule, Hyperplasia, Focal | 1 |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Regeneration | 2 1 2 2 2 1 2 3 1 2 2 1 3 2 1 3 3 2 2 1 2 2 2 2|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 205
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 4| 7| 7| 8| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 2 2.5|
Basophilic Focus | | 4 |
Clear Cell Focus | X | 12 |
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Focal | 3 | 18 2.7|
Inflammation, Chronic | | 2 2.0|
Mixed Cell Focus | | 2 |
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Karyomegaly | | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 4 2.3|
Kupffer Cell, Hyperplasia | | 4 2.3|
Lobules, Necrosis | | 8 2.6|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Accessory Spleen | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | | 4 1.3|
Cytoplasmic Alteration | | 1 4.0|
Focal Cellular Change | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | 1 | 13 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Inflammation, Subacute | | 1 3.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 206
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 4| 7| 7| 8| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Cyst | | 5 |
Erosion | | 4 2.3|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Tooth | + | 7 |
Dysplasia | 4 | 7 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Myocardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X | 7 |
Basophilic Focus | X | 2 |
Clear Cell Focus | | 6 |
Hyperplasia, Focal | 1 1 | 20 1.5|
Hypertrophy, Focal | | 1 4.0|
Capsule, Hyperplasia | 3 | 11 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | 2 3 3 | 26 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | | 14 1.8|
Inflammation, Subacute | 2 | 3 1.3|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 7 |
Dilatation | 4 | 6 3.2|
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 207
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 4| 7| 7| 8| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | | 11 |
Ectasia | | 9 3.3|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 49 |
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Dilatation | 3 | 22 3.0|
Fibrosis | | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 1 | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Seminiferous Tubule, Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I + | 48 |
Hyperplasia, Lymphoid | 2 | 2 2.5|
Hyperplasia, Plasma Cell | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 48 |
Hematopoietic Cell Proliferation | 2 1 | 6 1.3|
Hemorrhage | 3 2 3 1 | 20 1.8|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 12 2.2|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Atrophy | | 3 3.0|
Lymphoid Follicle, Hyperplasia | 2 | 2 2.0|
Red Pulp, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + | 43 |
Cyst | X X | 8 |
Depletion Cellular | | 11 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 208
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 4| 7| 7| 8| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Cyst | X | 1 |
Hemorrhage | | 2 2.5|
Thalamus, Mineralization | 2 1 1 1 1 | 38 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 2 2.5|
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | | 3 1.7|
Infiltration Cellular, Histiocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Exudate | | 8 |
Glands, Hyperplasia, Cystic | | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Casts Protein | 1 | 10 1.2|
Cyst | X X X 2 | 25 2.0|
Granuloma | | 1 1.0|
Hyperplasia, Lymphoid | 1 1 | 10 1.3|
Inflammation, Chronic | 2 | 1 2.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 3 2 3 2 3 2 2 2 2 2 | 56 2.3|
Pigmentation, Cholesterol | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 209
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 7| 7| 4| 7| 7| 8| 7| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.00700% | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Atrophy | 1 1 2 2 | 16 1.4|
Renal Tubule, Dilatation | 2 1 1 1 1 | 15 1.3|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
Renal Tubule, Necrosis | | 2 1.0|
Renal Tubule, Regeneration | 2 3 3 2 3 1 2 1 2 1 | 55 2.0|
Transitional Epithelium, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Dilatation | | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 210
NTP Experiment-Test: 05089-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 15:57:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | |
| 8| 9| 7| 8| 7| 0| 1| 1| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| | A |
0.00700% | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | L |
3 SSAC | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 3 |
Renal Tubule, Regeneration | 1 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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