TR 392 Rat Pathology Tables
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Merge 001 001,002 0 ppm
Merge 002 003,004 0 ppm
Merge 003 015,016 50 ppm
Merge 004 013,014 50 ppm
Merge 005 009,010 100 ppm
Merge 006 011,012 100 ppm
Merge 007 005,006 200 ppm
Merge 008 007,008 200 ppm
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Early Deaths
Moribund Sacrifice 16 17 20 23
Natural Death 3 5 1 3
Survivors
Terminal Sacrifice 31 28 29 24
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Rectum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (49) (50)
Intestine Small, Ileum (50) (49) (49) (50)
Intestine Small, Jejunum (50) (50) (49) (50)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Mesentery (10) (11) (5) (9)
Pancreas (50) (50) (49) (50)
Salivary Glands (49) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (49)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (50) (49) (50) (50)
Pheochromocytoma Benign 6 (12%) 2 (4%) 5 (10%) 5 (10%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 4 (8%) 1 (2%)
Carcinoma 1 (2%)
Page 2
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (50) (49) (50) (50)
Pars Distalis, Adenoma 33 (66%) 29 (59%) 18 (36%) 31 (62%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 4 (8%) 4 (8%) 4 (8%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
Oral, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (50) (50) (49)
Adenoma 5 (10%) 8 (16%) 7 (14%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor NOS 1 (2%)
Uterus (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Endometrium, Deciduoma NOS 1 (2%)
Endometrium, Polyp Stromal 10 (20%) 9 (18%) 12 (24%) 11 (22%)
Endometrium, Sarcoma Stromal 1 (2%) 3 (6%) 1 (2%)
Vagina (8) (7) (11) (12)
Sarcoma 1 (13%) 1 (9%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (50) (50) (50) (50)
Lymph Node, Mandibular (48) (49) (49) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Thymus (49) (47) (49) (49)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenocarcinoma 2 (4%) 1 (2%) 1 (2%)
Adenoma 1 (2%) 1 (2%)
Fibroadenoma 11 (22%) 15 (30%) 13 (26%) 13 (26%)
Fibroadenoma, Multiple 5 (10%) 5 (10%) 6 (12%) 2 (4%)
Skin (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (50) (49) (50)
Glioma Malignant 1 (2%)
Glioma NOS 1 (2%)
Oligodendroglioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Thyroid Gland 2 (4%)
Nose (50) (50) (50) (50)
Glands, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (1)
Pinna, Schwannoma NOS 1 (100%) 1 (100%) 1 (100%)
Eye (3) (1) (5) (6)
Lids, Schwannoma NOS 1 (20%)
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Lipoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 8 (16%) 11 (22%) 15 (30%) 16 (32%)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 45 44 47
Total Primary Neoplasms 104 103 105 101
Total Animals with Benign Neoplasms 45 42 37 44
Total Benign Neoplasms 85 83 76 79
Total Animals with Malignant Neoplasms 16 15 22 19
Total Malignant Neoplasms 18 18 25 21
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2 4 1
Total Uncertain Neoplasms 1 2 4 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Early Deaths
Moribund Sacrifice 34 27 34 33
Natural Death 3 1 3 1
Survivors
Terminal Sacrifice 14 22 14 16
Animals Examined Microscopically 51 50 51 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (51) (50) (51) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Intestine Large, Cecum (51) (50) (50) (50)
Intestine Large, Colon (51) (50) (51) (49)
Intestine Large, Rectum (51) (50) (50) (49)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (51) (50) (51) (49)
Intestine Small, Jejunum (51) (50) (51) (49)
Adenocarcinoma 1 (2%)
Liver (51) (50) (51) (50)
Hepatocellular Adenoma 2 (4%) 4 (8%) 2 (4%)
Mesentery (31) (15) (15) (24)
Osteosarcoma, Metastatic, Bone 1 (3%)
Pancreas (51) (50) (51) (50)
Acinar Cell, Adenoma 4 (8%) 5 (10%) 1 (2%) 2 (4%)
Acinar Cell, Adenoma, Multiple 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (51) (50) (51) (50)
Stomach, Forestomach (51) (50) (51) (49)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (51) (50) (51) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (51) (50) (51) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (51) (50) (51) (50)
Adenoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (51) (50) (51) (50)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Benign 11 (22%) 16 (32%) 17 (33%) 14 (28%)
Bilateral, Pheochromocytoma Benign 12 (24%) 19 (38%) 10 (20%) 8 (16%)
Islets, Pancreatic (51) (50) (51) (50)
Adenoma 5 (10%) 5 (10%) 5 (10%) 10 (20%)
Carcinoma 2 (4%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (51) (50)
Pars Distalis, Adenoma 20 (40%) 29 (58%) 22 (43%) 19 (38%)
Thyroid Gland (51) (50) (51) (50)
C-Cell, Adenoma 6 (12%) 2 (4%) 3 (6%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (51) (50) (51) (50)
Preputial Gland (50) (50) (51) (50)
Adenoma 3 (6%) 2 (4%) 4 (8%) 1 (2%)
Carcinoma 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Sarcoma, Metastatic 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (51) (50) (51) (50)
Sarcoma, Metastatic 1 (2%)
Seminal Vesicle (51) (50) (51) (50)
Testes (51) (50) (51) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Bilateral, Interstitial Cell, Adenoma 26 (51%) 30 (60%) 30 (59%) 32 (64%)
Interstitial Cell, Adenoma 7 (14%) 14 (28%) 8 (16%) 11 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (51) (50) (51) (50)
Lymph Node (51) (50) (51) (50)
Lymph Node, Mandibular (51) (50) (51) (49)
Lymph Node, Mesenteric (51) (49) (51) (50)
Spleen (51) (50) (51) (50)
Page 8
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%)
Thymus (46) (46) (48) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (48) (49) (49)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Skin (51) (50) (51) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%) 5 (10%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma
Malignant 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Lymphangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (51) (50) (51) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Hindlimb, Sarcoma, Metastatic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (51) (50) (51) (50)
Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1)
Carcinoma, Metastatic, Thyroid Gland 1 (100%)
Lung (51) (50) (51) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 4 (8%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Page 9
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mediastinum, Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (51) (50) (51) (50)
Trachea (51) (50) (51) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Squamous Cell Papilloma 1 (50%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (51) (50) (51) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (51) (50) (51) (50)
Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(51) *(50) *(51) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 25 (49%) 26 (52%) 29 (57%) 30 (60%)
Mesothelioma Malignant 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLORAMINE Date: 05/19/97
Route: DOSED WATER Time: 09:11:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 51 50
Total Primary Neoplasms 144 176 154 152
Total Animals with Benign Neoplasms 47 50 50 49
Total Benign Neoplasms 105 144 114 113
Total Animals with Malignant Neoplasms 31 28 37 36
Total Malignant Neoplasms 39 32 40 39
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 7 4 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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