TR 392 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 05/07/97
EXPERIMENT: 05089 TEST: 01 TIME: 15:41:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: C91004
PATHOLOGIST: D. FARNELL CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: EXCLUDE 017 0.0275%
EXCLUDE 018 0.0275% 3 SSAC
EXCLUDE 019 0.0275%
EXCLUDE 020 0.0275% 3 SSAC
EXCLUDE 021 0.0140%
EXCLUDE 022 0.0140% 3 SSAC
EXCLUDE 023 0.0140%
EXCLUDE 024 0.0140% 3 SSAC
EXCLUDE 025 0.00700%
EXCLUDE 026 0.00700% 3 SSAC
EXCLUDE 027 0.00700%
EXCLUDE 028 0.00700% 3 SSAC
EXCLUDE 029 SENTINEL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 05/07/97
EXPERIMENT: 05089 TEST: 01 TIME: 15:41:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: C91004
PATHOLOGIST: D. FARNELL CAS: 10599903
RATS(FISCHER 344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 05/07/97
EXPERIMENT: 05089 TEST: 01 TIME: 15:41:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: C91004
PATHOLOGIST: D. FARNELL CAS: 10599903
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Fibroma
Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Testes Adenoma
All Organs Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Islets, Pancreatic Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
====================================================================================================
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/51 (45%) 35/50 (70%) 27/51 (53%) 22/50 (44%) | 7/50 (14%) 2/49 (4%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | 84.2% 84.8% 79.8% 72.6% | 21.9% 7.4% 16.3% 16.8% |
|TERMINAL (d) | 10/14 (71%) 16/22 (73%) 8/14 (57%) 9/16 (56%) | 6/31 (19%) 2/27 (7%) 2/29 (7%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 541 605 533 543 | 721 729 (T) 584 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231N P=0.446 P=0.325 P=0.300N | P=0.517 P=0.114N P=0.537N P=0.526N |
|INCIDENTAL TUMOR | P=0.086N P=0.140 P=0.362 P=0.269N | P=0.518N P=0.111N P=0.542N P=0.447N |
|LOGISTIC REGRESSION | P=0.098N P=0.111 P=0.343 P=0.275N | P=0.531N P=0.092N P=0.526N P=0.451N |
|COCHRAN-ARMITAGE | P=0.210N | P=0.495N |
|FISHER EXACT | P=0.010 ** P=0.276 P=0.536N | P=0.085N P=0.500N P=0.380N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/51 (4%) 0/50 (0%) 0/51 (0%) 0/50 (0%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.5% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 0/31 (0%) 0/27 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 675 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113N P=0.187N P=0.235N P=0.222N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.096N P=0.197N P=0.222N P=0.176N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.110N P=0.205N P=0.229N P=0.216N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.116N | (e) |
|FISHER EXACT | P=0.252N P=0.248N P=0.252N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/51 (49%) 35/50 (70%) 27/51 (53%) 22/50 (44%) | 7/50 (14%) 2/49 (4%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | 85.5% 84.8% 79.8% 72.6% | 21.9% 7.4% 16.3% 16.8% |
|TERMINAL (d) | 10/14 (71%) 16/22 (73%) 8/14 (57%) 9/16 (56%) | 6/31 (19%) 2/27 (7%) 2/29 (7%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 541 605 533 543 | 721 729 (T) 584 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.537N P=0.450 P=0.194N | P=0.517 P=0.114N P=0.537N P=0.526N |
|INCIDENTAL TUMOR | P=0.038N* P=0.279 P=0.541 P=0.132N | P=0.518N P=0.111N P=0.542N P=0.447N |
|LOGISTIC REGRESSION | P=0.048N* P=0.235 P=0.522 P=0.142N | P=0.531N P=0.092N P=0.526N P=0.451N |
|COCHRAN-ARMITAGE | P=0.127N | P=0.495N |
|FISHER EXACT | P=0.026 * P=0.422 P=0.380N | P=0.085N P=0.500N P=0.380N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 4/51 (8%) 1/50 (2%) | 5/48 (10%) 8/50 (16%) 7/50 (14%) 2/49 (4%) |
|ADJUSTED (b) | 14.5% 9.1% 22.3% 2.1% | 16.1% 23.7% 22.7% 4.3% |
|TERMINAL (d) | 1/14 (7%) 2/22 (9%) 2/14 (14%) 0/16 (0%) | 5/31 (16%) 4/28 (14%) 6/29 (21%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 465 729 (T) 690 543 | 729 (T) 540 667 508 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.294N P=0.344N P=0.502 P=0.270N | P=0.208N P=0.236 P=0.332 P=0.299N |
|INCIDENTAL TUMOR | P=0.309N P=0.504N P=0.479 P=0.387N | P=0.141N P=0.240 P=0.334 P=0.242N |
|LOGISTIC REGRESSION | P=0.274N P=0.462N P=0.528 P=0.372N | P=0.129N P=0.282 P=0.374 P=0.197N |
|COCHRAN-ARMITAGE | P=0.290N | P=0.120N |
|FISHER EXACT | P=0.500N P=0.511 P=0.309N | P=0.304 P=0.409 P=0.209N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 4/51 (8%) 1/50 (2%) | 1/48 (2%) 1/50 (2%) 0/50 (0%) 1/49 (2%) |
|ADJUSTED (b) | 2.3% 7.2% 9.3% 6.3% | 3.2% 2.1% 0.0% 3.3% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/14 (0%) 1/16 (6%) | 1/31 (3%) 0/28 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 537 661 519 729 (T) | 729 (T) 452 --- 703 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.578N P=0.597 P=0.202 P=0.738N | P=0.645N P=0.744 P=0.513N P=0.718 |
|INCIDENTAL TUMOR | P=0.560 P=0.381 P=0.182 P=0.703 | P=0.570N P=0.704 P=0.513N P=0.754N |
|LOGISTIC REGRESSION | P=0.522 P=0.458 P=0.112 P=0.748 | P=0.609N P=0.692N P=0.513N P=0.748 |
|COCHRAN-ARMITAGE | P=0.596N | P=0.614N |
|FISHER EXACT | P=0.500 P=0.187 P=0.753N | P=0.742N P=0.490N P=0.747N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 8/51 (16%) 2/50 (4%) | 6/48 (13%) 9/50 (18%) 7/50 (14%) 3/49 (6%) |
|ADJUSTED (b) | 16.4% 16.0% 29.6% 8.2% | 19.4% 25.2% 22.7% 7.5% |
|TERMINAL (d) | 1/14 (7%) 3/22 (14%) 2/14 (14%) 1/16 (6%) | 6/31 (19%) 4/28 (14%) 6/29 (21%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 465 661 519 543 | 729 (T) 452 667 508 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.458N P=0.203 P=0.293N | P=0.220N P=0.245 P=0.450 P=0.344N |
|INCIDENTAL TUMOR | P=0.375N P=0.583 P=0.175 P=0.451N | P=0.136N P=0.229 P=0.451 P=0.263N |
|LOGISTIC REGRESSION | P=0.355N P=0.644N P=0.175 P=0.410N | P=0.129N P=0.308 P=0.498 P=0.229N |
|COCHRAN-ARMITAGE | P=0.336N | P=0.125N |
|FISHER EXACT | P=0.643N P=0.188 P=0.339N | P=0.318 P=0.532 P=0.233N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/51 (10%) 5/50 (10%) 5/51 (10%) 10/50 (20%) | 0/50 (0%) 4/50 (8%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 23.4% 18.5% 24.3% 40.3% | 0.0% 12.2% 3.6% 0.0% |
|TERMINAL (d) | 2/14 (14%) 2/22 (9%) 2/14 (14%) 4/16 (25%) | 0/31 (0%) 2/28 (7%) 1/28 (4%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 605 662 533 636 | --- 662 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070 P=0.412N P=0.619N P=0.201 | P=0.348N P=0.057 P=0.480 (e) |
|INCIDENTAL TUMOR | P=0.091 P=0.473N P=0.625N P=0.216 | P=0.312N P=0.058 P=0.480 (e) |
|LOGISTIC REGRESSION | P=0.079 P=0.504N P=0.608N P=0.183 | P=0.312N P=0.060 P=0.480 (e) |
|COCHRAN-ARMITAGE | P=0.066 | P=0.297N |
|FISHER EXACT | P=0.617 P=0.630N P=0.123 | P=0.059 P=0.495 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/51 (4%) 0/50 (0%) 1/51 (2%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.2% 0.0% 2.2% 5.9% | 0.0% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 0/31 (0%) 1/28 (4%) 0/28 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 675 --- 562 719 | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510N P=0.179N P=0.500N P=0.484N | P=0.603N P=0.480 (e) (e) |
|INCIDENTAL TUMOR | P=0.449N P=0.197N P=0.452N P=0.398N | P=0.603N P=0.480 (e) (e) |
|LOGISTIC REGRESSION | P=0.496N P=0.190N P=0.494N P=0.456N | P=0.603N P=0.480 (e) (e) |
|COCHRAN-ARMITAGE | P=0.504N | P=0.567N |
|FISHER EXACT | P=0.252N P=0.500N P=0.508N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/51 (14%) 5/50 (10%) 6/51 (12%) 11/50 (22%) | 0/50 (0%) 5/50 (10%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 31.2% 18.5% 25.9% 43.8% | 0.0% 15.6% 3.6% 0.0% |
|TERMINAL (d) | 2/14 (14%) 2/22 (9%) 2/14 (14%) 4/16 (25%) | 0/31 (0%) 3/28 (11%) 1/28 (4%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 605 662 533 636 | --- 662 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107 P=0.189N P=0.493N P=0.309 | P=0.296N P=0.029 * P=0.480 (e) |
|INCIDENTAL TUMOR | P=0.143 P=0.227N P=0.471N P=0.359 | P=0.266N P=0.029 * P=0.480 (e) |
|LOGISTIC REGRESSION | P=0.120 P=0.245N P=0.472N P=0.301 | P=0.261N P=0.031 * P=0.480 (e) |
|COCHRAN-ARMITAGE | P=0.099 | P=0.243N |
|FISHER EXACT | P=0.394N P=0.500N P=0.205 | P=0.028 * P=0.495 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/51 (4%) 4/50 (8%) 2/51 (4%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 11.2% 15.9% 10.0% 0.0% | 3.2% 10.7% 3.4% 12.5% |
|TERMINAL (d) | 1/14 (7%) 3/22 (14%) 1/14 (7%) 0/16 (0%) | 1/31 (3%) 3/28 (11%) 1/29 (3%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | 687 653 625 --- | 729 (T) 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107N P=0.526 P=0.688N P=0.221N | P=0.223 P=0.268 P=0.747 P=0.217 |
|INCIDENTAL TUMOR | P=0.101N P=0.512 P=0.662N P=0.195N | P=0.223 P=0.268 P=0.747 P=0.217 |
|LOGISTIC REGRESSION | P=0.100N P=0.457 P=0.684N P=0.209N | P=0.222 P=0.268 P=0.747 P=0.217 |
|COCHRAN-ARMITAGE | P=0.114N | P=0.313 |
|FISHER EXACT | P=0.329 P=0.691N P=0.252N | P=0.309 P=0.753N P=0.309 |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 4/50 (8%) 0/51 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 3.8% 13.7% 0.0% 11.2% | 3.2% 3.6% 5.7% 9.7% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 0/14 (0%) 1/16 (6%) | 1/31 (3%) 1/28 (4%) 1/29 (3%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 674 618 --- 718 | 729 (T) 729 (T) 619 589 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.573N P=0.293 P=0.500N P=0.535 | P=0.125 P=0.739 P=0.477 P=0.251 |
|INCIDENTAL TUMOR | P=0.546N P=0.243 P=0.487N P=0.582 | P=0.171 P=0.739 P=0.548 P=0.328 |
|LOGISTIC REGRESSION | P=0.560N P=0.212 P=0.493N P=0.544 | P=0.162 P=0.739 P=0.496 P=0.302 |
|COCHRAN-ARMITAGE | P=0.583N | P=0.165 |
|FISHER EXACT | P=0.175 P=0.500N P=0.492 | P=0.753N P=0.500 P=0.309 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 1/50 (2%) 0/51 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.5% 0.0% 5.9% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/14 (0%) 0/16 (0%) | 0/31 (0%) 0/28 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- 577 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140 P=0.590 (e) P=0.267 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.145 P=0.590 (e) P=0.250 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.137 P=0.590 (e) P=0.196 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.137 | (e) |
|FISHER EXACT | P=0.495 (e) P=0.243 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 4/50 (8%) 0/51 (0%) 4/50 (8%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 3.8% 13.7% 0.0% 16.5% | 3.2% 3.6% 5.7% 9.7% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 0/14 (0%) 1/16 (6%) | 1/31 (3%) 1/28 (4%) 1/29 (3%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 674 618 --- 577 | 729 (T) 729 (T) 619 589 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234 P=0.293 P=0.500N P=0.220 | P=0.125 P=0.739 P=0.477 P=0.251 |
|INCIDENTAL TUMOR | P=0.256 P=0.243 P=0.487N P=0.232 | P=0.171 P=0.739 P=0.548 P=0.328 |
|LOGISTIC REGRESSION | P=0.237 P=0.212 P=0.493N P=0.197 | P=0.162 P=0.739 P=0.496 P=0.302 |
|COCHRAN-ARMITAGE | P=0.222 | P=0.165 |
|FISHER EXACT | P=0.175 P=0.500N P=0.175 | P=0.753N P=0.500 P=0.309 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 1/51 (2%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.6% 0.0% | 6.5% 3.6% 3.4% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 2/31 (6%) 1/28 (4%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 703 --- | 729 (T) 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.696 (e) P=0.489 (e) | P=0.189N P=0.536N P=0.523N P=0.296N |
|INCIDENTAL TUMOR | P=0.721 (e) P=0.513 (e) | P=0.189N P=0.536N P=0.523N P=0.296N |
|LOGISTIC REGRESSION | P=0.701 (e) P=0.505 (e) | P=0.189N P=0.536N P=0.523N P=0.296N |
|COCHRAN-ARMITAGE | P=0.693 | P=0.153N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 0/50 (0%) 1/51 (2%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.4% 0.0% 5.6% 0.0% | 9.7% 3.6% 3.4% 3.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 3/31 (10%) 1/28 (4%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 541 --- 703 --- | 729 (T) 729 (T) 729 (T) 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397N P=0.469N P=0.756N P=0.478N | P=0.299N P=0.341N P=0.328N P=0.382N |
|INCIDENTAL TUMOR | P=0.430N P=0.892N P=0.717 P=0.638N | P=0.285N P=0.341N P=0.328N P=0.355N |
|LOGISTIC REGRESSION | P=0.441N P=0.691N P=0.754 P=0.650N | P=0.269N P=0.341N P=0.328N P=0.338N |
|COCHRAN-ARMITAGE | P=0.408N | P=0.242N |
|FISHER EXACT | P=0.505N P=0.752N P=0.505N | P=0.309N P=0.309N P=0.309N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/51 (4%) 1/50 (2%) 1/51 (2%) 2/50 (4%) | 16/50 (32%) 20/50 (40%) 19/50 (38%) 15/50 (30%) |
|ADJUSTED (b) | 14.3% 4.5% 7.1% 8.9% | 43.5% 54.6% 55.0% 44.5% |
|TERMINAL (d) | 2/14 (14%) 1/22 (5%) 1/14 (7%) 1/16 (6%) | 11/31 (35%) 12/28 (43%) 14/29 (48%) 7/24 (29%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 656 | 578 626 584 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.554 P=0.342N P=0.500N P=0.639N | P=0.442 P=0.199 P=0.274 P=0.430 |
|INCIDENTAL TUMOR | P=0.560 P=0.342N P=0.500N P=0.633N | P=0.408N P=0.226 P=0.286 P=0.528N |
|LOGISTIC REGRESSION | P=0.563 P=0.342N P=0.500N P=0.652N | P=0.418N P=0.229 P=0.284 P=0.536N |
|COCHRAN-ARMITAGE | P=0.551 | P=0.363N |
|FISHER EXACT | P=0.508N P=0.500N P=0.684 | P=0.266 P=0.338 P=0.500N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/51 (6%) 1/50 (2%) 1/51 (2%) 2/50 (4%) | 17/50 (34%) 20/50 (40%) 19/50 (38%) 16/50 (32%) |
|ADJUSTED (b) | 16.3% 4.5% 7.1% 8.9% | 46.3% 54.6% 55.0% 46.2% |
|TERMINAL (d) | 2/14 (14%) 1/22 (5%) 1/14 (7%) 1/16 (6%) | 12/31 (39%) 12/28 (43%) 14/29 (48%) 7/24 (29%) |
|FIRST INCIDENCE (DAYS) | 541 729 (T) 729 (T) 656 | 578 626 584 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.473N P=0.182N P=0.295N P=0.433N | P=0.418 P=0.254 P=0.343 P=0.420 |
|INCIDENTAL TUMOR | P=0.498N P=0.306N P=0.345N P=0.498N | P=0.428N P=0.291 P=0.360 P=0.529N |
|LOGISTIC REGRESSION | P=0.456N P=0.260N P=0.291N P=0.467N | P=0.440N P=0.298 P=0.359 P=0.540N |
|COCHRAN-ARMITAGE | P=0.479N | P=0.383N |
|FISHER EXACT | P=0.316N P=0.309N P=0.509N | P=0.339 P=0.418 P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/51 (6%) 1/50 (2%) 2/51 (4%) 2/50 (4%) | 19/50 (38%) 21/50 (42%) 19/50 (38%) 16/50 (32%) |
|ADJUSTED (b) | 16.3% 4.5% 12.3% 8.9% | 52.0% 57.5% 55.0% 46.2% |
|TERMINAL (d) | 2/14 (14%) 1/22 (5%) 1/14 (7%) 1/16 (6%) | 14/31 (45%) 13/28 (46%) 14/29 (48%) 7/24 (29%) |
|FIRST INCIDENCE (DAYS) | 541 729 (T) 703 656 | 578 626 584 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.499N P=0.182N P=0.497N P=0.433N | P=0.512N P=0.310 P=0.493 P=0.554 |
|INCIDENTAL TUMOR | P=0.509N P=0.306N P=0.536N P=0.498N | P=0.285N P=0.356 P=0.521 P=0.384N |
|LOGISTIC REGRESSION | P=0.481N P=0.260N P=0.483N P=0.467N | P=0.287N P=0.373 P=0.523 P=0.381N |
|COCHRAN-ARMITAGE | P=0.506N | P=0.237N |
|FISHER EXACT | P=0.316N P=0.500N P=0.509N | P=0.419 P=0.582N P=0.338N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 2/51 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 0.0% | 3.2% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 1/31 (3%) 0/28 (0%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 447 --- | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.606 (e) P=0.247 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|INCIDENTAL TUMOR | P=0.542 (e) P=0.217 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|LOGISTIC REGRESSION | P=0.386 (e) P=0.127 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|COCHRAN-ARMITAGE | P=0.592 | P=0.405N |
|FISHER EXACT | (e) P=0.248 (e) | P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 2/51 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 0.0% | 3.2% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 1/31 (3%) 0/28 (0%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 447 --- | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.606 (e) P=0.247 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|INCIDENTAL TUMOR | P=0.542 (e) P=0.217 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|LOGISTIC REGRESSION | P=0.386 (e) P=0.127 (e) | P=0.451N P=0.520N P=0.747 P=0.551N |
|COCHRAN-ARMITAGE | P=0.592 | P=0.405N |
|FISHER EXACT | (e) P=0.248 (e) | P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/51 (8%) 6/50 (12%) 1/51 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 25.6% 27.3% 7.1% 12.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/14 (21%) 6/22 (27%) 1/14 (7%) 2/16 (13%) | 0/31 (0%) 0/28 (0%) 0/28 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 710 729 (T) 729 (T) 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.126N P=0.626N P=0.181N P=0.274N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.121N P=0.629N P=0.170N P=0.260N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.129N P=0.586 P=0.182N P=0.286N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.136N | (e) |
|FISHER EXACT | P=0.358 P=0.181N P=0.348N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 29/50 (58%) 22/51 (43%) 19/50 (38%) | 33/50 (66%) 29/49 (59%) 18/50 (36%) 31/50 (62%) |
|ADJUSTED (b) | 58.7% 70.2% 69.0% 58.1% | 78.1% 69.5% 46.0% 78.4% |
|TERMINAL (d) | 3/13 (23%) 11/22 (50%) 7/14 (50%) 5/16 (31%) | 22/31 (71%) 15/27 (56%) 9/29 (31%) 16/24 (67%) |
|FIRST INCIDENCE (DAYS) | 451 473 447 577 | 531 540 590 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.237N P=0.502 P=0.493 P=0.321N | P=0.393 P=0.489N P=0.017N* P=0.331 |
|INCIDENTAL TUMOR | P=0.187N P=0.046 * P=0.530 P=0.434N | P=0.303N P=0.381N P=0.003N** P=0.490N |
|LOGISTIC REGRESSION | P=0.235N P=0.050 * P=0.450 P=0.473N | P=0.359N P=0.365N P=0.003N** P=0.469N |
|COCHRAN-ARMITAGE | P=0.232N | P=0.326N |
|FISHER EXACT | P=0.055 P=0.453 P=0.500N | P=0.311N P=0.002N** P=0.418N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/51 (10%) 7/50 (14%) 4/51 (8%) 4/50 (8%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 25.1% 23.8% 18.2% 21.1% | 2.9% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 2/14 (14%) 3/22 (14%) 1/14 (7%) 2/16 (13%) | 0/31 (0%) 1/28 (4%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 674 654 583 712 | 702 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314N P=0.618 P=0.482N P=0.423N | P=0.265N P=0.749 P=0.512N P=0.531N |
|INCIDENTAL TUMOR | P=0.245N P=0.594 P=0.457N P=0.363N | P=0.240N P=0.749 P=0.536N P=0.455N |
|LOGISTIC REGRESSION | P=0.284N P=0.532 P=0.478N P=0.420N | P=0.246N P=0.757 P=0.506N P=0.507N |
|COCHRAN-ARMITAGE | P=0.325N | P=0.236N |
|FISHER EXACT | P=0.366 P=0.500N P=0.513N | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 4/50 (8%) 2/51 (4%) 5/50 (10%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.0% 11.2% 18.5% | 5.5% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 1/14 (7%) 1/16 (6%) | 1/31 (3%) 0/28 (0%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 667 690 656 | 666 --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.123 P=0.245 P=0.053 | P=0.218N P=0.265N P=0.524N P=0.279N |
|INCIDENTAL TUMOR | P=0.073 P=0.111 P=0.247 P=0.058 | P=0.203N P=0.251N P=0.537N P=0.242N |
|LOGISTIC REGRESSION | P=0.056 P=0.095 P=0.239 P=0.040 * | P=0.195N P=0.241N P=0.512N P=0.242N |
|COCHRAN-ARMITAGE | P=0.050 | P=0.188N |
|FISHER EXACT | P=0.056 P=0.248 P=0.027 * | P=0.247N P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 4/50 (8%) 2/51 (4%) 6/50 (12%) | 3/50 (6%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 2.1% 15.0% 11.2% 20.5% | 8.0% 0.0% 3.4% 5.7% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 1/14 (7%) 1/16 (6%) | 1/31 (3%) 0/28 (0%) 1/29 (3%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 465 667 690 619 | 666 --- 729 (T) 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 P=0.286 P=0.510 P=0.096 | P=0.599N P=0.141N P=0.329N P=0.551N |
|INCIDENTAL TUMOR | P=0.069 P=0.146 P=0.454 P=0.068 | P=0.526N P=0.127N P=0.351N P=0.440N |
|LOGISTIC REGRESSION | P=0.057 P=0.161 P=0.488 P=0.044 * | P=0.559N P=0.120N P=0.313N P=0.495N |
|COCHRAN-ARMITAGE | P=0.053 | P=0.556N |
|FISHER EXACT | P=0.175 P=0.500 P=0.053 | P=0.121N P=0.309N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 0/50 (0%) 0/51 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.1% 0.0% 0.0% 2.4% | 2.6% 0.0% 0.0% 5.7% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 0/31 (0%) 0/28 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 465 --- --- 619 | 668 --- --- 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.617 P=0.488N P=0.492N P=0.722N | P=0.233 P=0.510N P=0.505N P=0.475 |
|INCIDENTAL TUMOR | P=0.542 P=0.892N P=0.594N P=0.663 | P=0.303 P=0.500N P=0.536N P=0.580 |
|LOGISTIC REGRESSION | P=0.435 P=0.835N P=0.677N P=0.619 | P=0.247 P=0.491N P=0.491N P=0.511 |
|COCHRAN-ARMITAGE | P=0.592 | P=0.246 |
|FISHER EXACT | P=0.505N P=0.500N P=0.748 | P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/51 (6%) 3/50 (6%) 2/51 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 15.6% 10.6% 7.5% 11.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 1/22 (5%) 0/14 (0%) 1/16 (6%) | 0/31 (0%) 0/28 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 687 662 583 718 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.365N P=0.506N P=0.485N P=0.441N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.314N P=0.533N P=0.456N P=0.398N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.349N P=0.562N P=0.483N P=0.443N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.377N | (e) |
|FISHER EXACT | P=0.652 P=0.500N P=0.509N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 3/50 (6%) 1/51 (2%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 11.5% 4.8% 4.8% | 0.0% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 2/22 (9%) 0/14 (0%) 0/16 (0%) | 0/31 (0%) 1/28 (4%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 654 698 712 | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.433N P=0.462 P=0.749N P=0.722N | P=0.603N P=0.480 (e) (e) |
|INCIDENTAL TUMOR | P=0.407N P=0.450 P=0.753N P=0.713N | P=0.603N P=0.480 (e) (e) |
|LOGISTIC REGRESSION | P=0.431N P=0.399 P=0.764N P=0.741N | P=0.603N P=0.480 (e) (e) |
|COCHRAN-ARMITAGE | P=0.449N | P=0.567N |
|FISHER EXACT | P=0.301 P=0.752N P=0.748 | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/51 (10%) 6/50 (12%) 3/51 (6%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 25.1% 21.2% 11.9% 15.4% | 2.9% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 2/14 (14%) 3/22 (14%) 0/14 (0%) 1/16 (6%) | 0/31 (0%) 1/28 (4%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 674 654 583 712 | 702 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205N P=0.516N P=0.343N P=0.295N | P=0.265N P=0.749 P=0.512N P=0.531N |
|INCIDENTAL TUMOR | P=0.152N P=0.545N P=0.314N P=0.236N | P=0.240N P=0.749 P=0.536N P=0.455N |
|LOGISTIC REGRESSION | P=0.183N P=0.603N P=0.335N P=0.285N | P=0.246N P=0.757 P=0.506N P=0.507N |
|COCHRAN-ARMITAGE | P=0.214N | P=0.236N |
|FISHER EXACT | P=0.486 P=0.358N P=0.369N | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/51 (8%) 6/50 (12%) 3/51 (6%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 22.1% 21.2% 11.9% 15.4% | 0.0% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 2/14 (14%) 3/22 (14%) 0/14 (0%) 1/16 (6%) | 0/31 (0%) 1/28 (4%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 687 654 583 712 | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290N P=0.602 P=0.479N P=0.423N | P=0.603N P=0.480 (e) (e) |
|INCIDENTAL TUMOR | P=0.236N P=0.577 P=0.458N P=0.380N | P=0.603N P=0.480 (e) (e) |
|LOGISTIC REGRESSION | P=0.271N P=0.521 P=0.480N P=0.432N | P=0.603N P=0.480 (e) (e) |
|COCHRAN-ARMITAGE | P=0.306N | P=0.567N |
|FISHER EXACT | P=0.358 P=0.500N P=0.511N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/51 (65%) 44/50 (88%) 38/51 (75%) 43/50 (86%) | |
|ADJUSTED (b) | 96.7% 100.0% 100.0% 97.6% | |
|TERMINAL (d) | 13/14 (93%) 22/22 (100%) 14/14 (100%) 15/16 (94%) | |
|FIRST INCIDENCE (DAYS) | 446 579 533 524 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175 P=0.420N P=0.302 P=0.295 | |
|INCIDENTAL TUMOR | P=0.082 P=0.146 P=0.334 P=0.058 | |
|LOGISTIC REGRESSION | P=0.098 P=0.125 P=0.296 P=0.059 | |
|COCHRAN-ARMITAGE | P=0.035 * | |
|FISHER EXACT | P=0.005 ** P=0.195 P=0.012 * | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/51 (12%) 2/50 (4%) 3/51 (6%) 3/50 (6%) | 4/50 (8%) 4/50 (8%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 23.2% 5.2% 7.5% 10.6% | 10.6% 14.3% 13.8% 8.6% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 0/14 (0%) 1/16 (6%) | 2/31 (6%) 4/28 (14%) 4/29 (14%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 541 627 586 530 | 620 729 (T) 729 (T) 589 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.238N P=0.073N P=0.237N P=0.193N | P=0.521N P=0.594 P=0.600 P=0.580N |
|INCIDENTAL TUMOR | P=0.273N P=0.190N P=0.185N P=0.302N | P=0.434N P=0.632N P=0.597N P=0.380N |
|LOGISTIC REGRESSION | P=0.320N P=0.170N P=0.260N P=0.284N | P=0.424N P=0.631 P=0.628 P=0.471N |
|COCHRAN-ARMITAGE | P=0.262N | P=0.410N |
|FISHER EXACT | P=0.141N P=0.244N P=0.254N | P=0.643N P=0.643N P=0.500N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 2/50 (4%) 1/51 (2%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 8.7% 2.9% 0.0% | 3.2% 7.1% 6.9% 0.0% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/14 (0%) 0/16 (0%) | 1/31 (3%) 2/28 (7%) 2/29 (7%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 598 718 618 --- | 729 (T) 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240N P=0.620 P=0.760N P=0.480N | P=0.361N P=0.464 P=0.477 P=0.551N |
|INCIDENTAL TUMOR | P=0.237N P=0.540 P=0.698N P=0.536N | P=0.361N P=0.464 P=0.477 P=0.551N |
|LOGISTIC REGRESSION | P=0.246N P=0.541 P=0.746 P=0.565N | P=0.361N P=0.464 P=0.477 P=0.551N |
|COCHRAN-ARMITAGE | P=0.250N | P=0.296N |
|FISHER EXACT | P=0.492 P=0.752N P=0.505N | P=0.500 P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/51 (14%) 4/50 (8%) 4/51 (8%) 3/50 (6%) | 5/50 (10%) 6/50 (12%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 25.2% 13.5% 10.2% 10.6% | 13.7% 21.4% 20.7% 8.6% |
|TERMINAL (d) | 1/14 (7%) 1/22 (5%) 0/14 (0%) 1/16 (6%) | 3/31 (10%) 6/28 (21%) 6/29 (21%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 541 627 586 530 | 620 729 (T) 729 (T) 589 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130N P=0.136N P=0.258N P=0.124N | P=0.382N P=0.436 P=0.448 P=0.450N |
|INCIDENTAL TUMOR | P=0.143N P=0.315N P=0.175N P=0.211N | P=0.308N P=0.493 P=0.532 P=0.264N |
|LOGISTIC REGRESSION | P=0.175N P=0.293N P=0.286N P=0.200N | P=0.285N P=0.482 P=0.475 P=0.336N |
|COCHRAN-ARMITAGE | P=0.144N | P=0.262N |
|FISHER EXACT | P=0.274N P=0.263N P=0.167N | P=0.500 P=0.500 P=0.357N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 0/51 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.4% 3.6% 4.4% 2.7% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 1/31 (3%) 1/28 (4%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 729 (T) 560 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.313N P=0.333N P=0.517N P=0.342N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.229N P=0.324N P=0.438N P=0.266N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.273N P=0.313N P=0.458N P=0.312N |
|COCHRAN-ARMITAGE | (e) | P=0.279N |
|FISHER EXACT | (e) (e) (e) | P=0.309N P=0.500N P=0.309N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 0/51 (0%) 0/50 (0%) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.4% 7.1% 4.4% 2.7% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/14 (0%) 0/16 (0%) | 1/31 (3%) 2/28 (7%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 729 (T) 560 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.271N P=0.535N P=0.517N P=0.342N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.198N P=0.528N P=0.438N P=0.266N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.229N P=0.512N P=0.458N P=0.312N |
|COCHRAN-ARMITAGE | (e) | P=0.232N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.500N P=0.309N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 9/50 (18%) 12/50 (24%) 11/50 (22%) |
|ADJUSTED (b) | | 24.7% 27.4% 34.4% 34.3% |
|TERMINAL (d) | | 4/31 (13%) 6/28 (21%) 7/29 (24%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | | 508 626 605 591 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.240 P=0.558N P=0.366 P=0.363 |
|INCIDENTAL TUMOR | | P=0.409 P=0.491N P=0.422 P=0.578 |
|LOGISTIC REGRESSION | | P=0.371 P=0.494N P=0.397 P=0.526 |
|COCHRAN-ARMITAGE | | P=0.385 |
|FISHER EXACT | | P=0.500N P=0.405 P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 1/50 (2%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | | 0.0% 3.6% 8.3% 4.2% |
|TERMINAL (d) | | 0/31 (0%) 1/28 (4%) 1/29 (3%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) 620 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.301 P=0.480 P=0.113 P=0.449 |
|INCIDENTAL TUMOR | | P=0.351 P=0.480 P=0.139 P=0.449 |
|LOGISTIC REGRESSION | | P=0.346 P=0.480 P=0.124 P=0.449 |
|COCHRAN-ARMITAGE | | P=0.351 |
|FISHER EXACT | | P=0.500 P=0.121 P=0.500 |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 10/50 (20%) 15/50 (30%) 11/50 (22%) |
|ADJUSTED (b) | | 24.7% 30.7% 40.5% 34.3% |
|TERMINAL (d) | | 4/31 (13%) 7/28 (25%) 8/29 (28%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | | 508 626 605 591 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.239 P=0.532 P=0.166 P=0.363 |
|INCIDENTAL TUMOR | | P=0.417 P=0.595N P=0.197 P=0.578 |
|LOGISTIC REGRESSION | | P=0.374 P=0.597N P=0.175 P=0.526 |
|COCHRAN-ARMITAGE | | P=0.388 |
|FISHER EXACT | | P=0.598N P=0.178 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/51 (49%) 26/50 (52%) 29/51 (57%) 30/50 (60%) | 8/50 (16%) 11/50 (22%) 15/50 (30%) 16/50 (32%) |
|ADJUSTED (b) | 73.1% 65.5% 89.1% 80.8% | 20.8% 29.0% 39.3% 41.4% |
|TERMINAL (d) | 6/14 (43%) 10/22 (45%) 11/14 (79%) 10/16 (63%) | 4/31 (13%) 4/28 (14%) 8/29 (28%) 4/24 (17%) |
|FIRST INCIDENCE (DAYS) | 315 581 429 495 | 472 540 465 592 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244 P=0.186N P=0.337 P=0.464 | P=0.021 * P=0.280 P=0.077 P=0.036 * |
|INCIDENTAL TUMOR | P=0.132 P=0.540 P=0.233 P=0.188 | P=0.062 P=0.269 P=0.075 P=0.096 |
|LOGISTIC REGRESSION | P=0.164 P=0.503 P=0.223 P=0.213 | P=0.035 * P=0.322 P=0.087 P=0.058 |
|COCHRAN-ARMITAGE | P=0.139 | P=0.034 * |
|FISHER EXACT | P=0.460 P=0.276 P=0.182 | P=0.306 P=0.077 P=0.050 |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/51 (2%) 0/50 (0%) 2/51 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 0.0% 11.8% 2.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 1/14 (7%) 0/16 (0%) | 0/31 (0%) 0/28 (0%) 0/29 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 710 --- 701 587 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.507 P=0.453N P=0.493 P=0.730N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.530 P=0.464N P=0.515 P=0.750N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.511 P=0.449N P=0.502 P=0.758 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.496 | (e) |
|FISHER EXACT | P=0.505N P=0.500 P=0.748 | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/51 (92%) 50/50 (100%) 50/51 (98%) 49/50 (98%) | 45/50 (90%) 42/50 (84%) 37/50 (74%) 44/50 (88%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 95.7% 91.3% 84.0% 93.5% |
|TERMINAL (d) | 14/14 (100%) 22/22 (100%) 14/14 (100%) 16/16 (100%)| 29/31 (94%) 24/28 (86%) 22/29 (76%) 21/24 (88%) |
|FIRST INCIDENCE (DAYS) | 446 473 447 524 | 508 540 560 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.504 P=0.066N P=0.455 P=0.334N | P=0.184 P=0.551 P=0.220N P=0.203 |
|INCIDENTAL TUMOR | P=0.637N P=0.748 P=0.674 P=0.751 | P=0.418N P=0.436N P=0.040N* P=0.532N |
|LOGISTIC REGRESSION | P=0.544N P=0.543 P=0.523 P=0.667N | P=0.432N P=0.400N P=0.054N P=0.540N |
|COCHRAN-ARMITAGE | P=0.166 | P=0.448N |
|FISHER EXACT | P=0.061 P=0.181 P=0.187 | P=0.277N P=0.033N* P=0.500N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.0100% 0.0200% | VEHICLE 0.00500% 0.0100% 0.0200% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/51 (61%) 28/50 (56%) 37/51 (73%) 36/50 (72%) | 16/50 (32%) 15/50 (30%) 22/50 (44%) 19/50 (38%) |
|ADJUSTED (b) | 79.7% 71.3% 91.1% 86.3% | 40.6% 39.2% 52.8% 48.9% |
|TERMINAL (d) | 7/14 (50%) 12/22 (55%) 11/14 (79%) 11/16 (69%) | 9/31 (29%) 7/28 (25%) 11/29 (38%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | 315 581 429 495 | 472 452 465 592 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204 P=0.057N P=0.278 P=0.507 | P=0.117 P=0.571N P=0.146 P=0.201 |
|INCIDENTAL TUMOR | P=0.057 P=0.365N P=0.144 P=0.149 | P=0.297 P=0.585 P=0.155 P=0.428 |
|LOGISTIC REGRESSION | P=0.060 P=0.392N P=0.146 P=0.148 | P=0.216 P=0.491N P=0.162 P=0.339 |
|COCHRAN-ARMITAGE | P=0.067 | P=0.213 |
|FISHER EXACT | P=0.388N P=0.147 P=0.163 | P=0.500N P=0.151 P=0.338 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/51 (98%) 50/50 (100%) 51/51 (100%) 50/50 (100%)| 48/50 (96%) 45/50 (90%) 44/50 (88%) 47/50 (94%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 96.0% 93.7% 93.6% 95.9% |
|TERMINAL (d) | 14/14 (100%) 22/22 (100%) 14/14 (100%) 16/16 (100%)| 29/31 (94%) 25/28 (89%) 26/29 (90%) 22/24 (92%) |
|FIRST INCIDENCE (DAYS) | 315 473 429 495 | 472 299 465 465 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.477N P=0.032N* P=0.541N P=0.253N | P=0.154 P=0.540 P=0.468N P=0.198 |
|INCIDENTAL TUMOR | P=0.375 P=0.892 P=0.594 P=0.638 | P=0.418N P=0.328N P=0.193N P=0.433N |
|LOGISTIC REGRESSION | P=0.432 P=0.736 P=0.603 P=0.694 | P=0.525N P=0.249N P=0.209N P=0.504N |
|COCHRAN-ARMITAGE | P=0.307 | P=0.500N |
|FISHER EXACT | P=0.505 P=0.500 P=0.505 | P=0.218N P=0.134N P=0.500N |
|=================================================================================================================================|
DATE: 05/07/97 EXPERIMENT: 05089 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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