TR 392 Rat Pathology Tables
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Congestion | 2 |
Fatty Change | 1 1 2 3 3 2 |
Fibrosis, Focal | |
Focal Cellular Change | 2 2 2 1 1 2 1 1 1 2 2 2 1 2 2 1 2 2|
Granuloma | 2 1 1 1 2 2 1 2 2 1 1 2 2 2 1 1 2 1 1 2 1|
Hematopoietic Cell Proliferation | 1 1 1 1|
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 3 3 2 3|
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Multifocal | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 1 2 2 1 1 1 1 1 1 1 1 1 2 2 |
Biliary Tract, Fibrosis | 1 1 2 2 1 1 1 1 1 1 1 1 1 2 2 |
Centrilobular, Atrophy | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 2 3 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perforation | 4 |
Ulcer | 3 4 2 |
Mucosa, Hyperplasia, Papillary | 2 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Congestion | |
Focal Cellular Change | 1 2 1 2 1 2 1 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 3 3 2 2 3 3 3 3 3 2 2 2 1 |
Cyst | 2 2 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 2|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + M + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 3 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Proliferation | |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
Follicle, Cyst | 1 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Hydrometra | 1 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Vagina | + + + |
Cyst | 3 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 1 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2 3 |
Pancreatic, Angiectasis | 2 |
Renal, Angiectasis | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 2 1 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 3 3 4 2 3|
Hyperplasia, Histiocytic, Lymphoid | 2 |
Capsule, Hyperplasia, Histiocytic, | |
Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 3 2 3 1 2 2|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | 3 |
Inflammation, Chronic | 1 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 2 1 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + M + + + + + + + +|
Compression | 1 4 3 3 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Macrophage | 2 1 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Pyogranulomatous | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 3 3 |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Nephropathy | 4 1 2 2 2 3 3 1 2 3 2 2 3 2 3 2 2 3 3 2 2 2 2 3|
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2|
Basophilic Focus | |
Congestion | 2 2 |
Fatty Change | 3 3 4 2 |
Fibrosis, Focal | 3 |
Focal Cellular Change | 1 1 1 2 1 2 2 2 1 2 2 2 1 2 2 2|
Granuloma | 1 2 1 2 1 3 1 1 2 2 1 2 2 1 2 2 1 2|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 2 2 2 2 2|
Hyperplasia, Histiocytic, Lymphoid | 3 |
Hyperplasia, Multifocal | 2 2 1 1 1 2 |
Infiltration Cellular, Mixed Cell | 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Biliary Tract, Fibrosis | 1 1 1 2 1 1 1 1 1 1 1 1 |
Centrilobular, Atrophy | 2 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 1 |
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perforation | 3 |
Ulcer | 2 3 4 |
Mucosa, Hyperplasia, Papillary | 3 1 2 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 4 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | 3 |
Focal Cellular Change | 1 1 1 1 4 1 1 1 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 3 2 2 2 2 2 3 3 2 3 4 3 2 4 3 3 2|
Cyst | 2 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 3 |
Inflammation, Suppurative | 3 2 1 3 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Proliferation | |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
Follicle, Cyst | 1 |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 1 |
__________________________________________________________________________|
Vagina | + + + + + + |
Cyst | 3 X 3 2 4 |
Inflammation, Suppurative | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 1 1 1 1 |
Pancreatic, Angiectasis | |
Renal, Angiectasis | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2|
Hyperplasia, Histiocytic, Lymphoid | |
Capsule, Hyperplasia, Histiocytic, | |
Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 1 2 2 2 2 2 2 2 2 2 3 2|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | |
Inflammation, Chronic | 2 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + M + + +|
Compression | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Foreign Body | 3 |
Hemorrhage | |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | 2 2|
Inflammation, Pyogranulomatous | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Fungus | 3 2 |
Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + + |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 2 1 1 |
Nephropathy | 1 1 1 1 1 1 2 2 1 2 2 3 2 3 3 1 2 2 2 3|
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 1| 1| 1| 1| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.7|
Basophilic Focus | | 1 |
Congestion | | 3 2.0|
Fatty Change | | 10 2.4|
Fibrosis, Focal | | 1 3.0|
Focal Cellular Change | 1 2 1 2 1 1 1 1 1 | 43 1.5|
Granuloma | 1 2 2 2 1 2 1 | 46 1.5|
Hematopoietic Cell Proliferation | | 6 1.3|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | | 10 2.3|
Hyperplasia, Histiocytic, Lymphoid | | 1 3.0|
Hyperplasia, Multifocal | | 7 1.6|
Infiltration Cellular, Mixed Cell | | 4 2.0|
Necrosis, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 1 1 1 1 | 41 1.2|
Biliary Tract, Fibrosis | 2 | 28 1.2|
Centrilobular, Atrophy | | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Accessory Spleen | | 1 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 5 2.4|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 | 8 1.1|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Focal Cellular Change | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 1| 1| 1| 1| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 1.0|
Inflammation, Chronic | | 7 2.7|
Perforation | | 2 3.5|
Ulcer | | 6 3.0|
Mucosa, Hyperplasia, Papillary | | 9 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Artery, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Congestion | | 1 3.0|
Focal Cellular Change | 1 1 | 19 1.3|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 3 2 3 2 2 1 1 1 | 46 2.3|
Cyst | | 3 2.0|
Pars Distalis, Focal Cellular Change | 1 | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 | 7 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 3 1.0|
Ultimobranchial Cyst | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 1| 1| 1| 1| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 1 1 1 1 1 | 17 1.1|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | | 3 2.7|
Inflammation, Suppurative | | 11 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Corpus Luteum, Proliferation | 3 | 1 3.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | 3 | 1 3.0|
Follicle, Cyst | | 2 1.0|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 2 3.5|
Hydrometra | | 2 1.5|
Inflammation, Suppurative | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 1 2 | 27 1.3|
__________________________________________________________________________|____________|
Vagina | + | 10 |
Cyst | 2 | 8 2.7|
Inflammation, Suppurative | 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 2.0|
Myelofibrosis | 1 | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | 2 1 | 9 1.6|
Pancreatic, Angiectasis | | 1 2.0|
Renal, Angiectasis | 2 | 1 2.0|
Renal, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Angiectasis | | 3 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 1| 1| 1| 1| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 2 | 12 2.8|
Hyperplasia, Histiocytic, Lymphoid | 2 | 2 2.0|
Capsule, Hyperplasia, Histiocytic, | | |
Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 1 2 2 | 40 2.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Inflammation, Chronic | | 3 1.7|
Ulcer | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 | 10 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Compression | 3 | 11 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Foreign Body | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Macrophage | | 3 1.7|
Infiltration Cellular, Mixed Cell | 2 | 3 2.0|
Inflammation, Pyogranulomatous | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 4.0|
Fungus | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 1| 1| 1| 1| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
VEHICLE | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 3 3.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Hyperplasia, Lymphoid | 1 | 5 1.8|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 | 9 1.2|
Nephropathy | 1 3 2 2 1 1 2 1 1 2 | 54 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 3| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
VEHICLE | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Granuloma | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 1 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 3| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
VEHICLE | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myelofibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 4 |
Hyperplasia, Glandular | 2 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 2 2 2 3 | 4 2.3|
Inflammation, Chronic | 2 2 2 3 | 4 2.3|
Metaplasia, Squamous | 2 2 2 | 3 2.0|
Necrosis | 2 2 2 | 3 2.0|
Acinus, Dilatation | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 2 1 1 1 1 1 1 | 9 1.1|
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|
| 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Fatty Change | 1 1 2 2 2 |
Focal Cellular Change | 2 1 2 1 1 1 1 2 2 1 2 2 2 2 2 2|
Granuloma | 1 2 1 1 2 1 1 1 1 2 1 2 2 1 1 3 2 2 2 1|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Histiocytic, Lymphoid | 2 |
Hyperplasia, Multifocal | 2 1 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 2 |
Necrosis, Focal | 2 2 |
Bile Duct, Hyperplasia | 1 1 2 2 3 1 1 1 1 1 2 1 1 1 2 2 1 1|
Biliary Tract, Fibrosis | 1 1 2 2 2 1 1 1 1 2 1 |
Centrilobular, Atrophy | 2 2 3 |
Centrilobular, Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + I + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 3 2 |
Perforation | 4 |
Ulcer | 4 |
Mucosa, Hyperplasia, Papillary | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|
| 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 1 2 1 2 1 1 2 2 |
Hyperplasia | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 2 2 3 2 2 2 2 2 3 1 2 3 3 3 3 1|
Cyst | 2 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 3 2 |
Inflammation, Suppurative | 3 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Corpus Luteum, Proliferation | |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydrometra | 2 2 2|
Inflammation, Suppurative | 2 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|
| 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Lamina Propria, Hyperplasia | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2|
Horn, Atrophy | 4 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + + + + + + |
Cyst | 3 2 2 X |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Angiectasis | |
Inguinal, Hyperplasia | |
Inguinal, Inflammation, Suppurative | 3 |
Mediastinal, Angiectasis | 3 2 2 3 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 3 3 2 2 2 2 |
Hyperplasia, Histiocytic, Lymphoid | 2 2 3 1 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 1 2 3 2 2 2 2 2 2 1 1 1 3 4 2|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|
| 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 2 3 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Atrophy | 4 |
Cataract | 3 3 3 4 |
Retina, Degeneration | 4 3 3 4 4 |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 4 2 2 |
Hydronephrosis | 3 |
Inflammation, Suppurative | 3 |
Mineralization | |
Nephropathy | 2 4 3 3 3 2 2 3 4 3 4 4 3 2 1 2 2 3 2 1 3 3 3 4 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|
| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Fatty Change | 3 2 3 2 |
Focal Cellular Change | 1 1 1 1 2 1 2 2 2 2 2 1 1 1 |
Granuloma | 1 2 1 1 1 1 2 1 2 2 1 1 2 1 2 2 1 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 2 2 3 3 |
Hyperplasia, Histiocytic, Lymphoid | 2 |
Hyperplasia, Multifocal | 2 2 2 3 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 |
Inflammation, Focal | |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 1 1 1 2 1 2 1 2 1 1|
Biliary Tract, Fibrosis | 1 1 1 1 1 1 1 2 1 1|
Centrilobular, Atrophy | 2 2 4 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Chronic | |
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 3 3 |
Perforation | |
Ulcer | 3 3 |
Mucosa, Hyperplasia, Papillary | 1 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|
| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 2 2 |
Hyperplasia | 4 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 1 2 3 2 2 2 3 2 2 2 3 3 3 2 3 2|
Cyst | 3 2 |
Hemorrhage | 3 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 1 |
Inflammation, Suppurative | 2 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Corpus Luteum, Proliferation | 2 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 3 |
Follicle, Cyst | 1 |
Periovarian Tissue, Cyst | 3 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydrometra | 2 2 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|
| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Lamina Propria, Hyperplasia | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 1 1 2 2 1 1|
Horn, Atrophy | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + + +|
Cyst | X X|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Angiectasis | 3 |
Inguinal, Hyperplasia | 2 2 |
Inguinal, Inflammation, Suppurative | |
Mediastinal, Angiectasis | 1 2 1 2 2 |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 2 |
Hyperplasia, Histiocytic, Lymphoid | 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 4|
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|
| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0200% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 3 |
Hyperplasia, Macrophage | 2 2 2|
Infiltration Cellular, Mixed Cell | 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Hydronephrosis | |
Inflammation, Suppurative | |
Mineralization | 1 1 1 2 |
Nephropathy | 1 1 1 1 1 3 1 2 2 2 2 1 2 3 2 1 1 1 3 3 4 3 2 3 3|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5| | |
| 5| 2| 7| 7| 9| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 5 1.4|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.0|
Congestion | | 1 2.0|
Fatty Change | 3 3 | 11 2.2|
Focal Cellular Change | 1 2 1 | 33 1.5|
Granuloma | 1 1 1 2 1 2 | 44 1.4|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | 3 2 | 9 2.7|
Hyperplasia, Histiocytic, Lymphoid | | 2 2.0|
Hyperplasia, Multifocal | 2 2 | 15 2.0|
Infiltration Cellular, Mixed Cell | 2 | 9 2.0|
Inflammation, Focal | | 1 2.0|
Necrosis, Focal | | 3 1.7|
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 | 42 1.4|
Biliary Tract, Fibrosis | 1 2 1 1 2 | 26 1.3|
Centrilobular, Atrophy | 3 3 | 9 2.6|
Centrilobular, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 2 2 | 6 1.3|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Diverticulum | 3 | 1 3.0|
Inflammation, Chronic | 3 | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5| | |
| 5| 2| 7| 7| 9| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | | 1 4.0|
Ulcer | 3 | 4 3.3|
Mucosa, Hyperplasia, Papillary | 3 | 6 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Focal Cellular Change | 1 2 3 1 | 17 1.6|
Hyperplasia | | 2 3.5|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 9 1.4|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 3 3 3 2 3 1 2 2 2 2 | 47 2.3|
Cyst | | 3 2.3|
Hemorrhage | | 1 3.0|
Pars Distalis, Focal Cellular Change | 1 2 | 2 1.5|
Pars Distalis, Hyperplasia, Focal | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 2 1 1 1 2 1 | 14 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 2 | 2 2.0|
Hyperplasia | | 3 2.0|
Inflammation, Suppurative | 1 | 6 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5| | |
| 5| 2| 7| 7| 9| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Corpus Luteum, Proliferation | | 1 2.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 1 3.0|
Follicle, Cyst | | 2 1.5|
Periovarian Tissue, Cyst | 3 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Hydrometra | 1 3 | 8 1.9|
Inflammation, Suppurative | | 2 2.5|
Cervix, Lamina Propria, Hyperplasia | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 | 20 1.9|
Horn, Atrophy | | 1 4.0|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + + + | 13 |
Cyst | 3 3 | 8 2.6|
Inflammation, Suppurative | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 5 2.8|
Myelofibrosis | 3 1 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Inguinal, Angiectasis | | 1 3.0|
Inguinal, Hyperplasia | | 2 2.0|
Inguinal, Inflammation, Suppurative | | 1 3.0|
Mediastinal, Angiectasis | 2 1 2 2 | 13 1.9|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Angiectasis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | | 2 1.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | 2 | 4 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 9 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5| | |
| 5| 2| 7| 7| 9| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic, Lymphoid | | 6 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 1 2 2 | 38 2.0|
Hyperplasia | | 7 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 9 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 7 2.7|
Hemorrhage | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Macrophage | | 3 2.0|
Infiltration Cellular, Mixed Cell | 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 3 2.0|
Inflammation, Suppurative | 1 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 7 |
Atrophy | 4 | 2 4.0|
Cataract | | 5 3.4|
Retina, Degeneration | 4 | 7 3.7|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
Hyperplasia, Lymphoid | 1 2 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5| | |
| 5| 2| 7| 7| 9| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Cyst | | 3 2.7|
Hydronephrosis | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 1 1 1 | 7 1.1|
Nephropathy | 2 2 2 2 2 3 1 1 1 | 59 2.3|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 3| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Granuloma | 1 1 1 1 | 4 1.0|
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 3| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myelofibrosis | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
Atrophy | 4 | 1 4.0|
Hydrocephalus | 3 | 1 3.0|
Mineralization, Focal | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 5 |
Hyperplasia, Glandular | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 2 1 | 3 1.3|
Inflammation, Chronic | 1 2 1 | 3 1.3|
Acinus, Dilatation | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 3| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.0200% | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 2 1 1 1 1 2 1 1 | 10 1.2|
Nephropathy | 1 1 | 2 1.0|
Renal Tubule, Dilatation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0100% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 2 |
Fatty Change | 2 1 1 3 2 |
Focal Cellular Change | 1 2 1 1 2 1 1 1 2 2 2 2 1 2 2 1 2 |
Granuloma | 2 1 2 2 1 1 2 1 1 2 1 1 1 2 2 3 1 1 1|
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | 2 3 2 |
Hyperplasia, Multifocal | 2 1 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 2 1 1 2 2 1 1 1 1 3 2 2 1 |
Biliary Tract, Fibrosis | 2 1 2 1 1 1 1 1 1 1 1 2 3 1 2 |
Centrilobular, Atrophy | 3 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 2 1 1 1 1 |
Edema | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Edema | 2 |
Inflammation, Chronic | 3 2 |
Perforation | 4 |
Ulcer | 4 |
Mucosa, Hyperplasia, Papillary | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0100% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Degeneration | 3 |
Fibrosis | 2 |
Focal Cellular Change | 2 1 2 2 2 2 1 2 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 1 2 2 1 1 2 2 3 1 2 2 2 2 2 4 3|
Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 |
Inflammation, Suppurative | 1 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | 3 |
Hydrometra | 3 3 2 2 |
Inflammation, Suppurative | 1 3 |
Endometrium, Hyperplasia, Cystic | 1 2 1 1 1 2 1 1 2 2 1 2 1 2 2 1 3 2|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0100% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | + + + +|
Cyst | 3 2 3|
Inflammation, Suppurative | 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 3 |
Mediastinal, Angiectasis | 2 3 |
Mediastinal, Hyperplasia | 3 |
Pancreatic, Angiectasis | 4 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 1 |
Developmental Malformation | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 4 4 4 2 |
Hyperplasia, Histiocytic, Lymphoid | 4 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 3 2 2|
Fibrosis | 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Exudate | |
Hemorrhage | |
Inflammation, Chronic | |
Ulcer | |
Sebaceous Gland, Cyst | |
Subcutaneous Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0100% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Macrophage | 2 |
Alveolar Epithelium, Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Hemorrhage | |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 1 2 2 2 2 4 3 2 2 3 3 1 3 3 2 1 2 2 2 3 1 2 2 3 3|
Pigmentation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|
| 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0100% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Fatty Change | 4 3 2 3 2 4 1|
Focal Cellular Change | 1 2 2 1 2 2 2 2 2 2 2 1 |
Granuloma | 1 1 1 1 1 1 1 3 2 1 1 2 1|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 3 2 |
Hyperplasia, Multifocal | 2 1 2 |
Infiltration Cellular, Mixed Cell | 2 |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 2 1 2 |
Biliary Tract, Fibrosis | 1 1 1 1 1 1 2 1 1 |
Centrilobular, Atrophy | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Edema | |
Inflammation, Chronic | 2 3 4 |
Perforation | |
Ulcer | 3 4 |
Mucosa, Hyperplasia, Papillary | 1 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|
| 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0100% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Degeneration | |
Fibrosis | |
Focal Cellular Change | 1 1 1 1 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 3 2 3 3 3 3 2 3 2 2 2 |
Cyst | 3 3|
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 3 1 1 3 1 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Hydrometra | 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 1 2 2 1 2 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|
| 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0100% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | + + + + + |
Cyst | 2 3 1 3 3 |
Inflammation, Suppurative | 2 3 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2 |
Mediastinal, Angiectasis | 2 2 2 3 |
Mediastinal, Hyperplasia | |
Pancreatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Developmental Malformation | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Histiocytic, Lymphoid | 1 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + +|
Cyst | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Fibrosis | |
Hyperplasia | 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Exudate | |
Hemorrhage | 2 |
Inflammation, Chronic | 2 |
Ulcer | 2 |
Sebaceous Gland, Cyst | 2 |
Subcutaneous Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|
| 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0100% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + +|
Compression | 2 3 1 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + +|
Cataract | 3 2|
Hemorrhage | 3|
Retina, Degeneration | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | 3 |
Mineralization | |
Nephropathy | 1 1 3 2 2 2 4 2 2 2 1 2 1 2 1 1 1 1 2 4|
Pigmentation | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 8| 7| 2| 2| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.0100% | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Parasite Metazoan | | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | | 3 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 3 2.0|
Cyst | | 1 2.0|
Fatty Change | 3 | 13 2.4|
Focal Cellular Change | 1 1 1 | 32 1.6|
Granuloma | 2 2 2 1 | 36 1.4|
Hematopoietic Cell Proliferation | 1 | 3 1.7|
Hepatodiaphragmatic Nodule | | 6 2.5|
Hyperplasia, Multifocal | 2 | 8 1.8|
Infiltration Cellular, Mixed Cell | | 3 2.0|
Necrosis, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 | 35 1.4|
Biliary Tract, Fibrosis | 1 1 | 26 1.3|
Centrilobular, Atrophy | 2 | 4 2.3|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Inflammation, Chronic | | 3 2.7|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Atrophy, Focal | | 7 1.4|
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Cyst | | 1 1.0|
Edema | | 1 2.0|
Inflammation, Chronic | | 5 2.8|
Perforation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 8| 7| 2| 2| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.0100% | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 3 3.7|
Mucosa, Hyperplasia, Papillary | | 5 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Angiectasis | 2 | 1 2.0|
Congestion | | 1 2.0|
Degeneration | | 1 3.0|
Fibrosis | | 1 2.0|
Focal Cellular Change | | 14 1.5|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Angiectasis | 1 3 | 36 2.2|
Cyst | 2 | 4 2.5|
Pars Distalis, Hyperplasia, Focal | 1 | 9 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Hyperplasia | 2 | 11 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 50 |
Degeneration, Cystic | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 8| 7| 2| 2| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.0100% | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 6 2.0|
Inflammation, Suppurative | | 9 1.9|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Follicle, Cyst | | 1 3.0|
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Decidual Reaction | | 1 3.0|
Hydrometra | | 5 2.6|
Inflammation, Suppurative | | 2 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 1 | 38 1.5|
__________________________________________________________________________|____________|
Vagina | + + | 11 |
Cyst | 2 3 | 10 2.5|
Inflammation, Suppurative | 3 3 | 8 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Inguinal, Hyperplasia | 3 | 3 2.7|
Mediastinal, Angiectasis | 2 | 7 2.3|
Mediastinal, Hyperplasia | | 1 3.0|
Pancreatic, Angiectasis | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 49 |
Angiectasis | | 3 2.0|
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Angiectasis | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Depletion Cellular | | 2 1.5|
Developmental Malformation | | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 7 3.0|
Hyperplasia, Histiocytic, Lymphoid | | 2 2.5|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 49 |
Cyst | | 2 2.0|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 8| 7| 2| 2| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.0100% | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Dilatation | 2 2 | 40 2.0|
Fibrosis | | 1 2.0|
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Erosion | 2 | 1 2.0|
Exudate | 4 | 1 4.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 4 | 2 3.0|
Ulcer | | 1 2.0|
Sebaceous Gland, Cyst | | 1 2.0|
Subcutaneous Tissue, Foreign Body | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | 2 | 11 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 49 |
Compression | | 5 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Macrophage | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Fungus | 2 | 3 1.7|
Inflammation, Suppurative | 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | 4 | 4 3.3|
Hemorrhage | | 1 3.0|
Retina, Degeneration | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5| | |
| 6| 8| 7| 2| 2| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.0100% | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Atrophy | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 | 2 1.5|
Nephropathy | 1 1 2 2 3 | 50 2.0|
Pigmentation | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Necrosis | 4 |
Parasite Metazoan | |
Perforation | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2|
Congestion | 2 |
Fatty Change | 4 3 2 3 2 1 2 3 1 2 3 3 1 2 |
Focal Cellular Change | 2 2 2 2 2 1 2 2 1 2 2|
Granuloma | 2 1 1 1 2 1 1 3 1 1 1 3 2 2 1 1 1 2 1 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Multifocal | 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2|
Necrosis, Focal | 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1|
Biliary Tract, Fibrosis | 1 1 1 2 1 2 1 1 1 1|
Centrilobular, Atrophy | 2 2 3 2 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | 2 |
Inflammation, Chronic | 3 2 2 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 2 1|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic | 2 3 |
Perforation | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Focal Cellular Change | 1 1 1 1 1 1 1 1 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 1 3 3 4 3 3 3 3 3 2 3 3 3 2 2 2 3|
Cyst | 1 |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 |
Inflammation, Suppurative | 3 2 2 3 4|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 2 1 1 2 1 2 1 1 1 2 1 2 2 2 1 1 1|
__________________________________________________________________________|
Vagina | + + + |
Cyst | 3 3 2 |
Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 3 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 3 |
Pancreatic, Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 2 3 2 2 2 |
Hyperplasia, Histiocytic, Lymphoid | 2 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + M + + + + + + + + + +|
Cyst | 1 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 1 2 2 2 2 4 2 2 3 4 2 2 2 2 2 2|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.00500% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 3 3 2 3 2|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Suppurative | 2 |
Mineralization | 1 |
Nephropathy | 1 1 2 1 1 1 4 3 3 3 2 3 1 3 2 2 3 2 1 1 4 3 3 3|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|
| 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.00500% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis | |
Parasite Metazoan | 1 2 |
Perforation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Fatty Change | 2 4 1 |
Focal Cellular Change | 1 2 1 1 2 1 2 1 2 2 1 2 2 1 2 2 2 2 2|
Granuloma | 1 1 1 2 1 2 2 2 2 1 1 2 1 2 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 3 3 3 |
Hyperplasia, Histiocytic, Lymphoid | 2 |
Hyperplasia, Multifocal | 2 2 |
Infiltration Cellular, Mixed Cell | 2 4 2 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1|
Biliary Tract, Fibrosis | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Centrilobular, Atrophy | 2 3 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | |
Inflammation, Chronic | 2 2 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Inflammation, Chronic | 3 |
Perforation | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|
| 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.00500% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Congestion | |
Focal Cellular Change | 2 2 1 |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 1 |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 4 3 3 3 1 3 3 2 2 2 2 3 2 1 |
Cyst | |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 3 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|
| 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.00500% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 3 |
Periovarian Tissue, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Vagina | + + + + |
Cyst | 3 1 4 |
Inflammation, Suppurative | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Pancreatic, Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic, Lymphoid | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 1 2 1 2 2 2 2 2 1 2 3 1 3 2 2|
Hyperplasia | 2 2 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|
| 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.00500% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 2 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 3 2 2 2 |
Hemorrhage | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 |
Hemorrhage | 3 2 |
Hyperplasia, Macrophage | |
Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 3 2|
Inflammation, Suppurative | 2 1 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 2 2 2 3 2 2 3 3 2 1 1 2 2 3 4 2 3 2 2 2|
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5| | |
| 0| 2| 6| 0| 1| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.00500% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Inflammation, Chronic | | 1 4.0|
Necrosis | | 1 4.0|
Parasite Metazoan | | 2 1.5|
Perforation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | 1 | 4 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 2 2.5|
Congestion | | 1 2.0|
Fatty Change | | 17 2.3|
Focal Cellular Change | 1 1 1 1 1 | 35 1.6|
Granuloma | 2 2 2 | 38 1.5|
Hematopoietic Cell Proliferation | | 2 2.0|
Hepatodiaphragmatic Nodule | 2 | 5 2.8|
Hyperplasia, Histiocytic, Lymphoid | | 1 2.0|
Hyperplasia, Multifocal | 1 | 6 1.8|
Infiltration Cellular, Mixed Cell | 2 | 11 2.2|
Necrosis, Focal | | 3 1.7|
Bile Duct, Hyperplasia | 1 1 | 32 1.1|
Biliary Tract, Fibrosis | 1 1 | 27 1.1|
Centrilobular, Atrophy | 2 | 7 2.3|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Accessory Spleen | | 1 2.0|
Inflammation, Chronic | | 6 2.2|
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy, Focal | | 6 1.2|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5| | |
| 0| 2| 6| 0| 1| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.00500% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Chronic | | 3 2.7|
Perforation | | 1 3.0|
Ulcer | | 2 3.5|
Mucosa, Hyperplasia, Papillary | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Angiectasis | | 2 2.5|
Congestion | 2 | 2 2.0|
Focal Cellular Change | 1 1 | 14 1.1|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 49 |
Developmental Malformation | | 1 1.0|
Hyperplasia | | 6 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Angiectasis | 2 4 1 1 3 | 40 2.5|
Cyst | | 1 1.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Hyperplasia | 2 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5| | |
| 0| 2| 6| 0| 1| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.00500% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Abdominal, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 50 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | | 4 2.0|
Inflammation, Suppurative | 3 | 8 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 1 3.0|
Periovarian Tissue, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Hydrometra | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 | 32 1.6|
__________________________________________________________________________|____________|
Vagina | | 7 |
Cyst | | 6 2.7|
Inflammation, Suppurative | | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | | 7 2.6|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Mediastinal, Angiectasis | | 3 2.7|
Pancreatic, Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 49 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Depletion Cellular | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 8 2.3|
Hyperplasia, Histiocytic, Lymphoid | 1 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5| | |
| 0| 2| 6| 0| 1| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.00500% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + | 47 |
Cyst | | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Dilatation | 2 2 2 2 2 | 43 2.0|
Hyperplasia | | 3 2.3|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | 1 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | 4 3 | 16 2.6|
Hemorrhage | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 3 2.7|
Hemorrhage | | 3 2.3|
Hyperplasia, Macrophage | | 1 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Fungus | | 7 2.0|
Inflammation, Suppurative | | 8 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5| | |
| 0| 2| 6| 0| 1| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.00500% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Fibrosis | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 1.0|
Nephropathy | 1 1 2 3 | 48 2.2|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|
| 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy, Focal | |
Fatty Change | 4 3 2 1 2 |
Focal Cellular Change | 1 1 2 2 1 1 2 2 1 1 2 2 1 2 1 2 2 1|
Granuloma | 1 2 1 2 2 2 1 2 1 1 1 1 2 3 2 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 3 3 2 2|
Hyperplasia, Multifocal | 2 2 2 2|
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 2 1 1 2 3 1 1 1 1 1 2 2|
Biliary Tract, Fibrosis | 1 1 1 1 1 2 1 1 1 2 1|
Centrilobular, Atrophy | 3 2 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | 3 |
Mucosa, Hyperplasia, Papillary | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mucosa, Cyst | 1 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|
| 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Thrombosis | |
Pericardium, Edema | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 |
Congestion | 2 2 |
Focal Cellular Change | 1 2 2 1 2 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 1 2 4 3 2 1 3 3 3 1 2 2 3 2|
Atrophy | 1 |
Cyst | 2 2 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
C-Cell, Hyperplasia | 1 2 2 1 1 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia | 2 1 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|
| 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | 4 2 4 4 |
Periovarian Tissue, Cyst | 2 |
__________________________________________________________________________|
Oviduct | |
Dilatation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
Hydrometra | 2 |
Intussusception | |
Endometrium, Hyperplasia, Cystic | 2 2 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Vagina | + + + |
Cyst | 2 X |
Exudate, Mucous | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Inflammation, Suppurative | 2 |
Mediastinal, Angiectasis | 3 2 3 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia | |
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 2 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 2 3 4 4 |
Hemorrhage | 3 |
Hyperplasia, Histiocytic, Lymphoid | 2 2 4 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|
| 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1 2 2 2|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Macrophage | |
Inflammation, Chronic, Focal | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | |
Respiratory Epithelium, Degeneration,| |
Mucoid | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + M |
Cataract | |
Cornea, Inflammation, Chronic | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Lymphoid | 1 |
Acinus, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|
| 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Mineralization | 2 |
Nephropathy | 3 4 2 2 1 3 2 3 2 1 3 2 2 3 1 2 2 2 2 1 1 1 2 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|
| 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Atrophy, Focal | 2 |
Fatty Change | 2 3 |
Focal Cellular Change | 1 1 2 2 2 2 1 2 2 1 1 2 3 2 2 2|
Granuloma | 1 2 2 1 1 1 2 2 1 2 2 2 2 2 1 2 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 3 3 2 2 3 3 |
Hyperplasia, Multifocal | 2 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | |
Bile Duct, Hyperplasia | 1 2 2 1 2 1 2 2 2 2 1 2 2 1 3 2 1 2 1 2|
Biliary Tract, Fibrosis | 1 1 1 2 2 1 2 2 1 2 1 2 2 1 2 1 1|
Centrilobular, Atrophy | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Focal Cellular Change | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mucosa, Cyst | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|
| 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Thrombosis | |
Pericardium, Edema | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 2 |
Congestion | |
Focal Cellular Change | 2 2 1 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 2 3 3 1 2 3 2 2 3 2 4 2 2 4 2 2 3 4 |
Atrophy | |
Cyst | 2 1 3 1 |
Pars Distalis, Focal Cellular Change | 1 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
C-Cell, Hyperplasia | 1 1 1 1 1 2 2 2 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 3 2 |
Inflammation, Suppurative | 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|
| 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | 1 4 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Oviduct | + |
Dilatation | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 3 3 |
Hydrometra | |
Intussusception | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Vagina | + + + + + +|
Cyst | 1 3 3 4|
Exudate, Mucous | 2 |
Inflammation, Suppurative | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Inflammation, Suppurative | |
Mediastinal, Angiectasis | 1 1 1 3 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 2 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia | 2 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Hyperplasia, Histiocytic, Lymphoid | 2 1 4 2 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|
| 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 1 2 2 2 1 2 2 2 2 2 2 2 1 2 2 1|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Macrophage | 2 |
Inflammation, Chronic, Focal | 1 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 |
Respiratory Epithelium, Degeneration,| |
Mucoid | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Cornea, Inflammation, Chronic | 2 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia, Lymphoid | 2 2 |
Acinus, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|
| 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0275% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Mineralization | 2 2 2 2 2 |
Nephropathy | 2 2 1 1 2 1 2 1 1 3 1 2 3 3 2 3 1 2 2 3 2 3 3 3 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 9| 0| 0| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0275% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 | 4 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Atrophy, Focal | | 1 2.0|
Fatty Change | 2 2 | 9 2.3|
Focal Cellular Change | 2 1 2 1 1 1 1 | 41 1.6|
Granuloma | 2 1 2 2 1 1 2 1 | 41 1.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 3 2 2 | 16 2.6|
Hyperplasia, Multifocal | 2 2 2 | 14 2.0|
Infiltration Cellular, Mixed Cell | | 6 2.0|
Inflammation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 2 1 1 1 1 | 47 1.5|
Biliary Tract, Fibrosis | 1 1 1 1 2 1 | 34 1.3|
Centrilobular, Atrophy | 3 2 | 12 2.3|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Focal Cellular Change | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
Mucosa, Hyperplasia, Papillary | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 9| 0| 0| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0275% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Mucosa, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Dilatation | 2 | 1 2.0|
Thrombosis | 3 | 1 3.0|
Pericardium, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Angiectasis | | 2 2.0|
Congestion | | 2 2.0|
Focal Cellular Change | 2 1 | 15 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 2 3 2 2 1 2 1 2 2 | 49 2.2|
Atrophy | | 1 1.0|
Cyst | | 6 1.8|
Pars Distalis, Focal Cellular Change | 2 2 1 | 5 1.6|
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 2 1.0|
C-Cell, Hyperplasia | 1 1 1 1 1 | 22 1.3|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 9| 0| 0| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0275% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 | 2 3.0|
Hyperplasia | 2 3 | 8 2.1|
Inflammation, Suppurative | 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Follicle, Cyst | | 6 3.2|
Periovarian Tissue, Cyst | 2 | 2 2.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Hemorrhage | | 2 3.0|
Hydrometra | 2 2 2 | 4 2.0|
Intussusception | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 | 28 1.7|
__________________________________________________________________________|____________|
Vagina | + + | 11 |
Cyst | 2 | 7 2.5|
Exudate, Mucous | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 5 2.8|
Myelofibrosis | 4 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Inguinal, Inflammation, Suppurative | | 1 2.0|
Mediastinal, Angiectasis | 2 1 2 2 | 12 1.9|
Mediastinal, Hyperplasia, Histiocytic| 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 2.0|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia | | 1 2.0|
Renal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 9| 0| 0| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0275% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 3 2.0|
Hyperplasia, Histiocytic | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 2 | 4 2.5|
Hematopoietic Cell Proliferation | | 5 3.2|
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic, Lymphoid | | 8 2.5|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 2 | 42 1.8|
Hyperplasia | | 7 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 1 | 4 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 8 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Macrophage | 1 | 2 1.5|
Inflammation, Chronic, Focal | | 1 1.0|
Pigmentation | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 3 2.0|
Inflammation, Suppurative | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 9| 0| 0| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0275% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Degeneration,| | |
Mucoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 2.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 6 |
Hyperplasia, Lymphoid | 2 2 | 5 1.8|
Acinus, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 1 1 | 8 1.8|
Nephropathy | 2 2 2 2 2 1 1 1 1 | 58 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 3| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Granuloma | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + M + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 3| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.0275% | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + | 9 |
Hyperplasia, Glandular | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 1 2 2 1 1 1 1 | 8 1.4|
Inflammation, Chronic | 2 1 1 1 1 1 2 | 7 1.3|
Metaplasia, Squamous | 1 | 1 1.0|
Necrosis | 1 1 1 | 3 1.0|
Acinus, Dilatation | 2 2 2 2 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Mineralization | 1 1 1 1 2 2 2 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|
| 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0140% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Fatty Change | 2 2 3 2 |
Focal Cellular Change | 1 2 2 1 2 2 1 2 1 1 1 2 2 2 2 1 2 2|
Granuloma | 1 1 2 1 2 2 1 1 1 1 2 1 3 1 1 2 1 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 3 2 |
Hyperplasia, Multifocal | 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Necrosis, Focal | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 1 1 2 2 1 1 1 2 2 1 1|
Biliary Tract, Fibrosis | 1 1 1 1 1 2 2 1 1 2 1 1 |
Centrilobular, Atrophy | 2 2 3 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Angiectasis | 3 |
Inflammation, Chronic | 3 |
Fat, Necrosis | 2 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 1 1 1 1 1|
Inflammation, Chronic | 3 |
Acinar Cell, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 3 4 |
Ulcer | 2 |
Mucosa, Hyperplasia, Papillary | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|
| 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0140% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Aneurysm | |
Mesenteric Artery, Inflammation, | |
Chronic | |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 |
Focal Cellular Change | 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 2 1 2 3 4 2 1 3 2 2 3 3|
Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperplasia | 1 |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Vagina | + + + + + |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|
| 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0140% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 4 |
Exudate, Mucous | |
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 2 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2 2 3 2 |
Mediastinal, Hyperplasia, Histiocytic| |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis | 3 1 |
Hematopoietic Cell Proliferation | 2 3 3 |
Hemorrhage | |
Hyperplasia, Histiocytic, Lymphoid | 3 4 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 3 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|
| 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0140% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | 3 3 2 3 |
Hemorrhage | 3 2 3 3 |
Necrosis | 3 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Pyogranulomatous | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 2 |
Hemorrhage | 3 |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Hemorrhage | |
Pinna, Inflammation, Chronic | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 3 3 2 3 2 2 2 2 2 1 1 3 1 1 1 2 2 2 4 2 3 2|
Pigmentation | 3 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.0140% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | 1 1 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Congestion | 3 |
Fatty Change | 1 3 2 |
Focal Cellular Change | 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 |
Granuloma | 2 2 2 1 1 3 2 2 2 2 1 1 1 2 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Multifocal | 3 1 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 1 |
Necrosis, Focal | 2 2 1 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 2 1 2 1 1 1 2 1 1 1 1 1 1 2 2 1|
Biliary Tract, Fibrosis | 1 2 2 2 1 1 2 1 1 1 1 1 1|
Centrilobular, Atrophy | 2 2 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Angiectasis | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2|
Inflammation, Chronic | |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 1 |
Ulcer | |
Mucosa, Hyperplasia, Papillary | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.0140% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Aneurysm | 3 |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
Mesenteric Artery, Thrombosis | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | 2 1 2 1 1 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 3 2 3 3 2 1 2 3 3 2 1 1|
Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 1 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M|
Fibrosis | |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 1 4 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 1 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 1 1 1 2 1 1 2 2 2 2 3 2 3 3 1 2 2|
__________________________________________________________________________|
Vagina | + + + + |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.0140% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 4 2 2 2 |
Exudate, Mucous | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 X |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + M + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 4 3 |
Hemorrhage | 2 |
Hyperplasia, Histiocytic, Lymphoid | 3 4 2 |
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2 2 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Squamous | |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 2 3 3 2 2 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.0140% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | 3 2 2 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Macrophage | |
Inflammation, Chronic, Focal | |
Inflammation, Pyogranulomatous | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Hemorrhage | |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Hemorrhage | 1 |
Pinna, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 3 3 3 |
Inflammation, Suppurative | 1 |
Mineralization | |
Nephropathy | 2 1 1 3 2 2 3 2 3 2 1 3 2 1 2 1 3 3 2 1|
Pigmentation | |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5| | |
| 9| 1| 7| 4| 9| 8| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0140% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 51 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Parasite Metazoan | | 4 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 51 |
Angiectasis | | 3 2.0|
Congestion | 3 | 2 3.0|
Fatty Change | 2 3 3 3 | 11 2.4|
Focal Cellular Change | 2 1 2 | 36 1.7|
Granuloma | 2 2 2 | 36 1.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 3 2 | 7 2.6|
Hyperplasia, Multifocal | 2 2 | 9 2.0|
Infiltration Cellular, Mixed Cell | | 6 1.8|
Necrosis, Focal | 1 | 5 1.6|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 2 1 2 | 37 1.4|
Biliary Tract, Fibrosis | 2 2 1 2 | 29 1.3|
Centrilobular, Atrophy | 2 2 | 9 2.1|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Angiectasis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 51 |
Atrophy, Focal | 2 | 8 1.5|
Inflammation, Chronic | | 1 3.0|
Acinar Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 51 |
Diverticulum | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5| | |
| 9| 1| 7| 4| 9| 8| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0140% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 3 2.7|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia, Papillary | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 51 |
Edema | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Aneurysm | | 1 3.0|
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 3.0|
Mesenteric Artery, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Angiectasis | | 3 2.3|
Focal Cellular Change | 2 1 | 18 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
Hyperplasia | 1 | 8 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Angiectasis | 3 2 2 2 | 36 2.3|
Cyst | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 9 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 51 |
C-Cell, Hyperplasia | 2 2 | 11 1.6|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 50 |
Fibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5| | |
| 9| 1| 7| 4| 9| 8| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0140% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 3 1.7|
Inflammation, Suppurative | | 5 2.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 51 |
Follicle, Cyst | | 2 1.5|
Periovarian Tissue, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 51 |
Angiectasis | | 1 2.0|
Hydrometra | 3 | 3 3.0|
Endometrium, Hyperplasia, Cystic | 1 1 2 2 | 37 1.8|
__________________________________________________________________________|____________|
Vagina | + + + + | 13 |
Cyst | 3 3 | 7 2.9|
Exudate, Mucous | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 51 |
Hypercellularity | | 7 2.5|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
Mediastinal, Angiectasis | | 7 2.1|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Angiectasis | | 2 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 49 |
Angiectasis | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 51 |
Congestion | | 1 4.0|
Fibrosis | 1 | 4 1.5|
Hematopoietic Cell Proliferation | | 5 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic, Lymphoid | | 5 3.2|
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 50 |
Cyst | | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5| | |
| 9| 1| 7| 4| 9| 8| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0140% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 51 |
Dilatation | 2 2 2 2 | 40 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Erosion | | 1 2.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
Hyperostosis | 1 | 13 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 51 |
Compression | | 7 2.6|
Hemorrhage | | 4 2.8|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 51 |
Congestion | | 2 3.0|
Hemorrhage | 1 | 2 1.5|
Hyperplasia, Macrophage | | 1 1.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Pyogranulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
Fungus | | 3 1.7|
Hemorrhage | 3 | 2 3.0|
Inflammation, Suppurative | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Hemorrhage | | 1 1.0|
Pinna, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5| | |
| 9| 1| 7| 4| 9| 8| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0140% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 51 |
Congestion | | 1 3.0|
Fibrosis | | 3 3.0|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 1 | 2 1.0|
Nephropathy | 2 1 1 1 2 | 47 2.0|
Pigmentation | 3 | 2 3.0|
Renal Tubule, Degeneration, Hyaline | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|
| 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.00700% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Fatty Change | 4 2 2 2 1 1 2 1 2 4 1 |
Focal Cellular Change | 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Granuloma | 2 2 2 2 2 1 1 1 1 2 1 1 2 2 1 2 1 2 2 1|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 2 3 |
Hyperplasia, Histiocytic, Lymphoid | 1 |
Hyperplasia, Multifocal | 2 3 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1|
Biliary Tract, Fibrosis | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Atrophy | 2 3 2 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 4 |
Ulcer | 3 |
Mucosa, Hyperplasia, Papillary | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|
| 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.00700% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Chronic | 3 |
Necrosis | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Mesenteric Artery, Thrombosis | |
Thoracic, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 2 1 1 2 2 2 |
Metaplasia, Osseous | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 2 2 2 3 4 4 3 1 3 3 3 3 2 1 2 3 2 4|
Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M M + + + + + + + + + + + + + + +|
Fibrosis | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|
| 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.00700% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | 4 3|
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | 3 1 |
Inflammation, Suppurative | |
Prolapse | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 1 3 1 2 2 2 1 3 2 1|
__________________________________________________________________________|
Vagina | + + + + + + + |
Cyst | 3 3 2 3 2 |
Inflammation, Suppurative | 2 3 2 3 2 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2 |
Mediastinal, Angiectasis | 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 2 4 2 2|
Hyperplasia, Histiocytic, Lymphoid | 2 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 1 2 2 2|
Fibrosis | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 3 1 2 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|
| 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.00700% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 2 4 3 2 3|
Hemorrhage | |
Hydrocephalus | 2 |
Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Hemorrhage | |
Inflammation, Pyogranulomatous | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 3 3 2 2 2 1 3 3 3 1 3 2 1 2 4 3 2 1 1 2 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.00700% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Cyst | 3|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2|
Congestion | 2 |
Fatty Change | 2 2 2 2 1 2 |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Granuloma | 2 2 1 2 2 2 1 1 1 1 1 1 2 1 2 1|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 2 2 3 2 2 2 2|
Hyperplasia, Histiocytic, Lymphoid | 2 |
Hyperplasia, Multifocal | 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Necrosis, Focal | 2 2 |
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 1 2 1 2 1 1 1|
Biliary Tract, Fibrosis | 1 1 1 1 1 1 1 2 1 1|
Centrilobular, Atrophy | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 4 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | |
Ulcer | 1 |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.00700% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Chronic | |
Necrosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 2 |
Mesenteric Artery, Thrombosis | 3 |
Thoracic, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + + +|
Focal Cellular Change | 1 1 2 1 2 1 3 1 1|
Metaplasia, Osseous | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 2 3 4 3 3 2 3 2 2 3 2 4 2 3 2 2|
Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 1 1 1|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 |
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.00700% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | 3 3 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 3 |
Inflammation, Suppurative | |
Prolapse | 4 |
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 2 2 1 1 2 1|
__________________________________________________________________________|
Vagina | + + + + + |
Cyst | 2 3 3 3 |
Inflammation, Suppurative | 2 2 3 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Angiectasis | 2 2|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | 2 2 2 4 3 |
Hyperplasia, Histiocytic, Lymphoid | 3 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1|
Fibrosis | 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.00700% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 4 |
Hemorrhage | |
Hydrocephalus | |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 1 |
Inflammation, Pyogranulomatous | |
Alveolar Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3 2 1 |
Inflammation, Suppurative | 3 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + +|
Atrophy | |
Cataract | 4 3 3|
Retina, Degeneration | 4 4 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 2 4 4 2 1 2 2 2 3 2 2 2 1 1 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5| | |
| 4| 1| 9| 9| 9| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.00700% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | | 5 1.2|
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
Fibrosis | | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 2 2.0|
Congestion | | 1 2.0|
Fatty Change | 4 3 | 19 2.1|
Focal Cellular Change | 1 2 | 38 1.9|
Granuloma | 1 1 2 | 39 1.5|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | | 9 2.2|
Hyperplasia, Histiocytic, Lymphoid | | 2 1.5|
Hyperplasia, Multifocal | 2 | 8 2.1|
Infiltration Cellular, Mixed Cell | 2 | 8 2.0|
Necrosis, Focal | | 2 2.0|
Bile Duct, Hyperplasia | 2 1 1 1 | 42 1.2|
Biliary Tract, Fibrosis | 2 1 1 1 | 31 1.1|
Centrilobular, Atrophy | 2 | 5 2.2|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Chronic | | 2 3.0|
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy, Focal | 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5| | |
| 4| 1| 9| 9| 9| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.00700% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 3.0|
Inflammation, Chronic | 3 3 | 3 3.3|
Ulcer | 2 | 3 2.0|
Mucosa, Hyperplasia, Papillary | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Erosion | 1 | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 5 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 3 2.3|
Mesenteric Artery, Thrombosis | | 1 3.0|
Thoracic, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 49 |
Focal Cellular Change | | 16 1.5|
Metaplasia, Osseous | | 1 2.0|
Vacuolization Cytoplasmic | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 49 |
Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Angiectasis | 2 2 2 2 | 42 2.5|
Cyst | | 2 2.0|
Pars Distalis, Hyperplasia, Focal | | 9 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 48 |
Fibrosis | | 1 2.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 1 | 9 1.0|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5| | |
| 4| 1| 9| 9| 9| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.00700% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 50 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | 1 | 5 1.6|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Follicle, Cyst | | 4 3.3|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Hemorrhage | | 1 4.0|
Hydrometra | | 4 2.3|
Inflammation, Suppurative | 1 | 1 1.0|
Prolapse | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 2 | 33 1.8|
__________________________________________________________________________|____________|
Vagina | + + | 14 |
Cyst | | 9 2.7|
Inflammation, Suppurative | 1 | 10 2.3|
Mucosa, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hypercellularity | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | | 3 1.7|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Angiectasis | | 2 2.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Amyloid Deposition | | 1 2.0|
Hematopoietic Cell Proliferation | | 9 2.6|
Hyperplasia, Histiocytic, Lymphoid | | 6 1.7|
__________________________________________________________________________|____________|
Thymus | + + + M + | 47 |
Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5| | |
| 4| 1| 9| 9| 9| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.00700% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Dilatation | 2 2 2 4 2 | 43 1.9|
Fibrosis | | 1 2.0|
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Sebaceous Gland, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | 3 2 | 12 2.9|
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 1 2.0|
Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Foreign Body | | 1 1.0|
Hemorrhage | | 1 1.0|
Inflammation, Pyogranulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Foreign Body | 2 | 1 2.0|
Fungus | | 3 2.0|
Inflammation, Suppurative | 3 | 7 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 5 |
Atrophy | | 1 4.0|
Cataract | 4 | 4 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5| | |
| 4| 1| 9| 9| 9| 7| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.00700% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Degeneration | 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Fibrosis | | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | | 2 1.0|
Nephropathy | 1 4 2 | 45 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|
| 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 1 |
Atrophy, Focal | |
Basophilic Focus | |
Congestion | 3 |
Degeneration, Cystic | 2 2 1 1 1 1 2 1|
Fatty Change | 1 3 1 2 |
Focal Cellular Change | 1 2 2 1 2|
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | 3 2 2 2 |
Hyperplasia, Multifocal | 2 3 2 2 2 2 3 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 1 2 1 1 2 1 1 1|
Mineralization | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 3 2 2 2 2 2 2 2 3 2 3 3 1 2 1 3 1 2 1 2 2 1|
Biliary Tract, Fibrosis | 1 3 2 2 2 2 2 2 2 2 2 2 1 2 1 2 1 2 1 2 1|
Centrilobular, Atrophy | 2 3 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
Inflammation, Chronic | 1 2 2 2 2 |
Fat, Necrosis | 3 2 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 1 1 3 2 |
Cytoplasmic Alteration | 2 |
Acinar Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|
| 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 3 3 2 3 |
Ulcer | 3 2 2 3 |
Mucosa, Hyperplasia, Papillary | 3 3 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Inflammation, Chronic | 1 3 2 2 2 |
Mineralization | 3 |
Pigmentation, Focal | 1 1 |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | + |
Epithelium Alveolus, Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Inflammation, | |
Chronic | 3 2 2 |
Mesenteric Artery, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Focal Cellular Change | 1 1 1 2 1 2 1 1 1 1|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 2 1|
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 2 3 2 3 3 2 1|
Cyst | 2 2 |
Pigmentation | 3|
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|
| 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | 1 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | 1 |
Follicle, Hyperplasia, Macrophage | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 |
Fibrosis | 2 |
Inflammation, Suppurative | 1 3 1 2 1 4 1 1 1 1 1 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 3 1 2 1 2 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Germinal Epithelium, Degeneration | 3 3 2 3 3 3 3 3 3|
Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Mediastinal, Hyperplasia | |
Pancreatic, Hyperplasia | 2 |
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|
| 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Dilatation | 1 2 2 3 1 2 |
Hemorrhage | 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst Epithelial Inclusion | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 |
Hemorrhage | 1 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Acute | |
Necrosis, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Mediastinum, Hemorrhage | |
Mediastinum, Inflammation, Chronic | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 |
Inflammation, Suppurative | 1 1 1 1 1 2 3 |
Mucosa, Hyperplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|
| 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Pinna, Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Eye | +|
Atrophy | |
Cataract | |
Retina, Degeneration | |
Retrobulbar, Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4|
Nephropathy | 2 4 4 3 3 2 2 4 3 3 3 3 3 3 4 1 2 4 4 4 2 4 4 4 4|
Pelvis, Dilatation | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|
| 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 1 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 3 1 |
Atrophy, Focal | |
Basophilic Focus | |
Congestion | |
Degeneration, Cystic | 1 3 |
Fatty Change | 1 1 2 1 1 1 2 2 2 1 2 2 1|
Focal Cellular Change | 1 2 1 1 1 2 |
Hemorrhage | 1 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Multifocal | 3 2 2 2 2 2 3|
Infiltration Cellular, Mixed Cell | 2 2 2 2 |
Inflammation, Focal | 1 2 2 1 2 2 2 2 2 2 2 2 |
Mineralization | |
Necrosis, Focal | 3 1 |
Bile Duct, Hyperplasia | 2 2 1 2 2 1 1 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3|
Biliary Tract, Fibrosis | 2 1 1 1 2 2 2 3 2 1 2 1 2 2 2 1 2 2 2 2|
Centrilobular, Atrophy | 3 1 3 2 2 2 3|
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 3 3 1 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 1 1 1|
Cytoplasmic Alteration | |
Acinar Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|
| 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 3 |
Ulcer | 2 3 |
Mucosa, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 2 2 |
Mineralization | |
Pigmentation, Focal | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Epithelium Alveolus, Cyst | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Mesenteric Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | 2 |
Focal Cellular Change | 1 1 |
Hemorrhage | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia | 1 1 1 2 2 1 1 |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 3 3 3 3 3 2 |
Cyst | |
Pigmentation | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|
| 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | 1 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | |
Follicle, Hyperplasia, Macrophage | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Fibrosis | |
Inflammation, Suppurative | 2 2 2 1 4 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 2 2 1 4 2 1 3 2 3 1 2 2 1 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Germinal Epithelium, Degeneration | 3 2 3 3 3 3|
Interstitial Cell, Hyperplasia | 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 2 2 3 |
Mediastinal, Hyperplasia | |
Pancreatic, Hyperplasia | 3 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 2|
Hematopoietic Cell Proliferation | 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + M + + M M M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|
| 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3 |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Dilatation | 3 3 2 2 3 3 3 3 3 2 |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 2 1 3 1 3 4 4 |
Hemorrhage | 3 3 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis, Focal | 1 |
Hemorrhage | 2 1 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Acute | 2 |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Hemorrhage | 3 |
Mediastinum, Inflammation, Chronic | 3 |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 |
Inflammation, Suppurative | 1 3 2 1 1 2 2 1 |
Mucosa, Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|
| 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Pinna, Hyperplasia, Squamous | |
__________________________________________________________________________|
Eye | + + + + |
Atrophy | 3 |
Cataract | 4 |
Retina, Degeneration | 4 |
Retrobulbar, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Nephropathy | 2 2 2 2 2 3 3 3 3 3 2 4 3 4 4 2 2 4 3 4 3 1 3 3|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 6 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 8 1.5|
Atrophy, Focal | 2 | 1 2.0|
Basophilic Focus | 3 | 1 3.0|
Congestion | | 1 3.0|
Degeneration, Cystic | | 10 1.5|
Fatty Change | 2 1 1 1 1 1 | 23 1.4|
Focal Cellular Change | 2 1 | 13 1.5|
Hemorrhage | | 3 1.7|
Hepatodiaphragmatic Nodule | 2 3 | 6 2.3|
Hyperplasia, Multifocal | 2 | 15 2.3|
Infiltration Cellular, Mixed Cell | 2 | 7 2.0|
Inflammation, Focal | 2 2 2 1 1 1 1 | 27 1.6|
Mineralization | 2 | 1 2.0|
Necrosis, Focal | | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 1 1 2 | 57 1.9|
Biliary Tract, Fibrosis | 2 1 2 1 2 1 1 | 48 1.7|
Centrilobular, Atrophy | 2 | 14 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 32 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 2 | 7 1.9|
Fat, Necrosis | 3 3 3 | 12 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 2 | 14 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | | 1 2.0|
Acinar Cell, Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 7 2.9|
Ulcer | | 6 2.5|
Mucosa, Hyperplasia, Papillary | | 6 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 3 1.3|
Inflammation, Chronic | | 8 2.0|
Mineralization | | 1 3.0|
Pigmentation, Focal | | 2 1.0|
Ulcer | | 1 3.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Epithelium Alveolus, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
Aorta, Mineralization | | 1 3.0|
Mesenteric Artery, Inflammation, | | |
Chronic | | 4 2.3|
Mesenteric Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Cyst | | 1 2.0|
Focal Cellular Change | 1 | 13 1.2|
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Hyperplasia | 1 | 11 1.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 3 | 17 2.6|
Cyst | | 2 2.0|
Pigmentation | | 1 3.0|
Pars Distalis, Focal Cellular Change | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 2 | 10 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 | 6 1.3|
Pigmentation | | 2 1.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 | 7 1.3|
Follicle, Cyst | | 1 1.0|
Follicle, Hyperplasia, Macrophage | | 1 1.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 3 | 3 2.7|
Fibrosis | | 1 2.0|
Inflammation, Suppurative | 1 1 1 1 | 24 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 1 2 1 2 | 35 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Germinal Epithelium, Degeneration | | 15 2.9|
Interstitial Cell, Hyperplasia | 2 1 | 13 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 4 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Angiectasis | 2 | 6 2.3|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Hyperplasia | | 2 2.5|
Renal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | 2 2 | 3 2.0|
Hyperplasia | 2 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 6 2.3|
Hematopoietic Cell Proliferation | 1 | 3 2.0|
Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 54 |
Angiectasis | | 1 3.0|
Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M + | 56 |
Dilatation | | 16 2.4|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Cyst Epithelial Inclusion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 11 2.6|
Hemorrhage | | 5 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 2 1.5|
Hemorrhage | 1 | 7 1.6|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia, Macrophage | 1 | 3 1.7|
Infiltration Cellular, Mixed Cell | 2 | 3 2.0|
Inflammation, Acute | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 6 2.0|
Mediastinum, Hemorrhage | | 1 3.0|
Mediastinum, Inflammation, Chronic | | 1 3.0|
Pleura, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 3 | 5 1.8|
Inflammation, Suppurative | 3 3 | 17 1.7|
Mucosa, Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Glands, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 5 |
Atrophy | | 1 3.0|
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
Retrobulbar, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 4 2.8|
Nephropathy | 2 2 4 4 4 3 2 2 2 2 | 59 2.9|
Pelvis, Dilatation | 1 | 2 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
Renal Tubule, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 4| 3| 3| 9| 5| 5| 5| 5| 5| | |
| 5| 1| 1| 1| 5| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 4| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 4| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 6| 7| 6| 5| 5| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 1| 1| 3| 3| 9| 3| 3| 6| 9| 9| 5| 6| 3| 7| 6| 3| 3| 3| 7| 8| 3| 3| 3|
| 6| 8| 2| 2| 0| 0| 1| 6| 0| 1| 1| 1| 6| 1| 0| 7| 1| 1| 1| 1| 5| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + M + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Degeneration, Cystic | 1 1|
Eosinophilic Focus | 2 3 |
Fatty Change | 2 1 2 2 2 2 1 2 |
Focal Cellular Change | 1 1 1 2 2 1|
Hepatodiaphragmatic Nodule | 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 1|
Inflammation, Focal | 2 2 1 2 1 1 2|
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Thrombosis | 2 1 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 1 2 2 3 3 1 2 2 2 1 3 2 2 2 2 2 1 2|
Biliary Tract, Fibrosis | 1 2 2 2 1 2 2 2 3 2 1 1 2 2 1 2 1 2 2 1 2|
Centrilobular, Atrophy | 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 |
Fat, Necrosis | 3 3 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 2 |
Atrophy, Diffuse | |
Atrophy, Focal | 1 1 1 1 2 2 |
Edema | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 |
Ulcer | |
Mucosa, Hyperplasia, Papillary | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 6| 7| 6| 5| 5| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 1| 1| 3| 3| 9| 3| 3| 6| 9| 9| 5| 6| 3| 7| 6| 3| 3| 3| 7| 8| 3| 3| 3|
| 6| 8| 2| 2| 0| 0| 1| 6| 0| 1| 1| 1| 6| 1| 0| 7| 1| 1| 1| 1| 5| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 2 |
Mucosa, Cyst | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Focal Cellular Change | 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis, Focal | |
Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 2 3 2 3 2 |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 1 |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 |
Pigmentation | |
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Hyperplasia, Macrophage | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 6| 7| 6| 5| 5| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 1| 1| 3| 3| 9| 3| 3| 6| 9| 9| 5| 6| 3| 7| 6| 3| 3| 3| 7| 8| 3| 3| 3|
| 6| 8| 2| 2| 0| 0| 1| 6| 0| 1| 1| 1| 6| 1| 0| 7| 1| 1| 1| 1| 5| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Suppurative | 2 1 1 1 1 1 1 1 3 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Inflammation, Suppurative | 1 1 1 2 2 2 2 2 1 1 2 2 1 2 1 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Pancreatic, Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 3 |
Hematopoietic Cell Proliferation | 2 3 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Dilatation | 3 4 2 2 2 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Pigmentation | |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 6| 7| 6| 5| 5| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 1| 1| 3| 3| 9| 3| 3| 6| 9| 9| 5| 6| 3| 7| 6| 3| 3| 3| 7| 8| 3| 3| 3|
| 6| 8| 2| 2| 0| 0| 1| 6| 0| 1| 1| 1| 6| 1| 0| 7| 1| 1| 1| 1| 5| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Compression | 3 3 3 3 |
Hemorrhage | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | 3 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | |
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 3 3 3 3 1 3 3 3 2 2 3 3 3 3 4 3 3 3 3 2 3 3 3|
Pigmentation | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 2| 6| 9| 1| 2| 6| 3| 3| 3| 9| 0| 1| 3| 3| 4| 1| 6| 1| 3|
| 7| 7| 8| 8| 9| 7| 0| 4| 8| 8| 4| 7| 1| 1| 1| 7| 1| 8| 1| 1| 3| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 |
Degeneration, Cystic | 3 1 |
Eosinophilic Focus | |
Fatty Change | 1 1 1 1 3 1 3 3 1 3 |
Focal Cellular Change | 2 2 2 2 1 |
Hepatodiaphragmatic Nodule | 2 2 2 |
Hyperplasia, Multifocal | 3 3 3 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 |
Inflammation, Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Mixed Cell Focus | |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3 2 3 2 2 2 2 3 2 3|
Biliary Tract, Fibrosis | 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 1 3 1 3|
Centrilobular, Atrophy | 3 3 3 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 3 3 3 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 3 |
Atrophy, Diffuse | 3 |
Atrophy, Focal | 1 2 2 2 2 2 3 2 1 |
Edema | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Ulcer | 1 |
Mucosa, Hyperplasia, Papillary | 3 2 |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 2| 6| 9| 1| 2| 6| 3| 3| 3| 9| 0| 1| 3| 3| 4| 1| 6| 1| 3|
| 7| 7| 8| 8| 9| 7| 0| 4| 8| 8| 4| 7| 1| 1| 1| 7| 1| 8| 1| 1| 3| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | |
Mucosa, Cyst | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Fibrosis, Focal | 1 |
Hyperplasia | 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 2 3 3 2 2 2|
Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 1 |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Focal Cellular Change | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 1 |
Pigmentation | 1 1 |
C-Cell, Hyperplasia | 1 1|
Follicle, Hyperplasia, Macrophage | 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 2| 6| 9| 1| 2| 6| 3| 3| 3| 9| 0| 1| 3| 3| 4| 1| 6| 1| 3|
| 7| 7| 8| 8| 9| 7| 0| 4| 8| 8| 4| 7| 1| 1| 1| 7| 1| 8| 1| 1| 3| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 1 1 1 1 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Suppurative | 2 2 2 2 2 2 2 2 1 1 3 1 1 2 1 2 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 3 3 3 3 3 2 |
Interstitial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Pancreatic, Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 1 3 2 2|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
Subcutaneous Tissue, Pigmentation | 3 |
Subcutaneous Tissue, Fat, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 2| 6| 9| 1| 2| 6| 3| 3| 3| 9| 0| 1| 3| 3| 4| 1| 6| 1| 3|
| 7| 7| 8| 8| 9| 7| 0| 4| 8| 8| 4| 7| 1| 1| 1| 7| 1| 8| 1| 1| 3| 9| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0200% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Compression | 3 1 3 |
Hemorrhage | 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Foreign Body | 2|
Hemorrhage | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Foreign Body | |
Fungus | 2 2 3 2|
Inflammation, Suppurative | 3 2 3 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
Nephropathy | 2 2 2 2 2 2 3 2 3 3 2 2 4 3 3 3 3 3 3 2 2 3 3 3 3|
Pigmentation | 3 |
Renal Tubule, Hyperplasia | 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 2| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 5| 2| 2| 4| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0200% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 4 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 | 2 2.0|
Basophilic Focus | | 1 2.0|
Degeneration, Cystic | 2 | 5 1.6|
Eosinophilic Focus | | 2 2.5|
Fatty Change | 1 1 | 20 1.7|
Focal Cellular Change | 1 1 1 | 14 1.4|
Hepatodiaphragmatic Nodule | 2 3 | 6 2.2|
Hyperplasia, Multifocal | 2 2 | 12 2.3|
Infiltration Cellular, Mixed Cell | | 12 1.9|
Inflammation, Focal | 2 2 2 2 2 2 2 | 28 1.9|
Mixed Cell Focus | 3 | 1 3.0|
Necrosis, Focal | | 1 2.0|
Thrombosis | | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 59 2.0|
Biliary Tract, Fibrosis | 2 2 1 1 1 2 2 2 2 2 | 52 1.8|
Centrilobular, Atrophy | 2 2 | 13 2.4|
__________________________________________________________________________|____________|
Mesentery | + + + + | 28 |
Inflammation, Chronic | 2 | 4 1.8|
Fat, Necrosis | 3 3 3 | 15 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | | 2 2.5|
Atrophy, Diffuse | | 1 3.0|
Atrophy, Focal | 1 1 | 17 1.6|
Edema | | 1 2.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 2| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 5| 2| 2| 4| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0200% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + | 59 |
Inflammation, Chronic | | 5 1.8|
Ulcer | | 1 1.0|
Mucosa, Hyperplasia, Papillary | | 6 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + | 59 |
Edema | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mucosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Focal Cellular Change | 2 1 | 11 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Fibrosis, Focal | | 1 1.0|
Hyperplasia | | 11 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 3 1 3 1 | 23 2.3|
Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 2 1 | 11 1.7|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Nervosa, Focal Cellular Change | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 7 1.3|
Pigmentation | 1 | 3 1.0|
C-Cell, Hyperplasia | | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 2| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 5| 2| 2| 4| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0200% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Hyperplasia, Macrophage | 1 | 3 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | | 24 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 1 1.0|
Inflammation, Suppurative | 3 2 1 2 1 | 42 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | | 11 3.0|
Interstitial Cell, Hyperplasia | 1 2 | 9 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | 2 | 1 2.0|
Pancreatic, Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 7 2.3|
Hematopoietic Cell Proliferation | | 6 2.3|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 2| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 5| 2| 2| 4| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0200% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Dilatation | 3 3 | 14 2.5|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Subcutaneous Tissue, Pigmentation | | 1 3.0|
Subcutaneous Tissue, Fat, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Compression | 3 2 | 9 2.7|
Hemorrhage | 3 | 2 3.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Foreign Body | | 1 2.0|
Hemorrhage | 2 | 3 2.3|
Hyperplasia, Macrophage | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 1.0|
Foreign Body | 1 | 1 1.0|
Fungus | 2 2 2 | 9 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 2| 3| 5| 3| 5| 5| 5| 5| 5| | |
| 5| 2| 2| 4| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0200% | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 3 2 2 2 | 14 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.0|
Retina, Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 1.5|
Nephropathy | 1 2 3 3 3 2 2 2 2 2 | 60 2.6|
Pigmentation | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0200% | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 5| 5| 3| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
0.0200% | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
Mediastinal, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + M | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Necrosis | 1 | 1 1.0|
Acinus, Dilatation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 134
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 6| 7| 7| 0| 3| 3| 9| 9| 9| 7| 0| 2| 5| 9| 3| 9| 9| 3| 3| 3|
| 4| 1| 8| 0| 0| 2| 4| 5| 3| 0| 0| 0| 1| 6| 5| 5| 5| 6| 0| 0| 0| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0100% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2|
Congestion | |
Degeneration, Cystic | 2 2 2|
Eosinophilic Focus | |
Fatty Change | 1 1 3 2 |
Focal Cellular Change | 1 1 1 1 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 2 |
Hyperplasia, Multifocal | 3 2 3 3 2 3 2 2 2 3 2 |
Infiltration Cellular, Mixed Cell | 1 2 2 2 |
Inflammation, Focal | 2 2 2 2 2 2 2 |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 3 2 2 2 3 2 1 2 3 3 1 2 3 2 2 2 3|
Biliary Tract, Fibrosis | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2|
Centrilobular, Atrophy | 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | 2 3 |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 2 2 2 1 |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
Page 135
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 6| 7| 7| 0| 3| 3| 9| 9| 9| 7| 0| 2| 5| 9| 3| 9| 9| 3| 3| 3|
| 4| 1| 8| 0| 0| 2| 4| 5| 3| 0| 0| 0| 1| 6| 5| 5| 5| 6| 0| 0| 0| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0100% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | |
Perforation | 4 |
Ulcer | 4 |
Mucosa, Hyperplasia, Papillary | 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 1 |
Inflammation, Chronic | 2 2 1 |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 2 2 2 3 |
Hematopoietic Cell Proliferation | |
Mineralization | 1 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 3 3 3 3 2|
Atrophy | |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 136
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 6| 7| 7| 0| 3| 3| 9| 9| 9| 7| 0| 2| 5| 9| 3| 9| 9| 3| 3| 3|
| 4| 1| 8| 0| 0| 2| 4| 5| 3| 0| 0| 0| 1| 6| 5| 5| 5| 6| 0| 0| 0| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0100% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 1 1 1 1 2 1 1 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Suppurative | 2 4 1 2 2 1 2 2 2 2 1 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Germinal Epithelium, Degeneration | 3 3 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia | |
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia | |
Mediastinal, Angiectasis | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3|
Fibrosis | 3 2 2 2 3|
Hematopoietic Cell Proliferation | 2 3 3 4 2 |
Hyperplasia, Histiocytic | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +|
Cyst | 1 3|
Ectopic Parathyroid Gland | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 137
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 6| 7| 7| 0| 3| 3| 9| 9| 9| 7| 0| 2| 5| 9| 3| 9| 9| 3| 3| 3|
| 4| 1| 8| 0| 0| 2| 4| 5| 3| 0| 0| 0| 1| 6| 5| 5| 5| 6| 0| 0| 0| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0100% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + + + + + + + + + + + +|
Dilatation | 3 1 3 2 2|
Hyperplasia | |
Metaplasia, Cartilagenous | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic | 2 |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 1 2 2 |
Inflammation, Suppurative | 2 3 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Acinus, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 3 3 4 3 3 2 3 4 3 4 2 2 2 2 2 3 2 4 3 2 2 2 3 3 3|
Pigmentation | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 138
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 6| 7| 7| 0| 3| 3| 9| 9| 9| 7| 0| 2| 5| 9| 3| 9| 9| 3| 3| 3|
| 4| 1| 8| 0| 0| 2| 4| 5| 3| 0| 0| 0| 1| 6| 5| 5| 5| 6| 0| 0| 0| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0100% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Muscularis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 139
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 5| 5| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 4| 8| 4| 1| 3| 1| 0| 0| 3| 3| 8| 9| 3| 3| 3| 3| 6| 6| 1| 1|
| 7| 7| 8| 8| 9| 7| 6| 9| 9| 0| 9| 1| 2| 0| 0| 3| 6| 0| 0| 0| 9| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0100% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Congestion | 2 |
Degeneration, Cystic | 1 1 1 1 1 |
Eosinophilic Focus | 3 |
Fatty Change | 3 2 2 1 2 1 1 2 4 2 2 |
Focal Cellular Change | 1 2 1 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia, Multifocal | 3 2 3 2 3 2 2 3 2|
Infiltration Cellular, Mixed Cell | 2 2 2 3 3 |
Inflammation, Focal | 2 2 2 2 2 2 2 2 2 2 2 2 |
Necrosis, Focal | 1 1 |
Thrombosis | 2 2 |
Bile Duct, Dilatation | 3|
Bile Duct, Hyperplasia | 2 1 3 1 2 1 2 2 1 2 1 1 1 3 2 2 2 2 2 3|
Biliary Tract, Fibrosis | 2 1 3 1 2 2 2 1 2 1 1 1 2 2 1 2 2 2 2|
Centrilobular, Atrophy | 3 3 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 2 3 3|
Cytoplasmic Alteration | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
Page 140
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 5| 5| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 4| 8| 4| 1| 3| 1| 0| 0| 3| 3| 8| 9| 3| 3| 3| 3| 6| 6| 1| 1|
| 7| 7| 8| 8| 9| 7| 6| 9| 9| 0| 9| 1| 2| 0| 0| 3| 6| 0| 0| 0| 9| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0100% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 |
Perforation | |
Ulcer | 3 |
Mucosa, Hyperplasia, Papillary | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | |
Mineralization | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 2 1 1|
Hematopoietic Cell Proliferation | 2 |
Mineralization | |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 3 3 2 2 2 3 |
Atrophy | |
Cyst | 2 1 |
Pars Distalis, Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 141
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 5| 5| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 4| 8| 4| 1| 3| 1| 0| 0| 3| 3| 8| 9| 3| 3| 3| 3| 6| 6| 1| 1|
| 7| 7| 8| 8| 9| 7| 6| 9| 9| 0| 9| 1| 2| 0| 0| 3| 6| 0| 0| 0| 9| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0100% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 4 1 3 1 4 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Suppurative | 3 1 2 3 2 3 1 3 1 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
Germinal Epithelium, Degeneration | 3 3 3 3 3 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia | 2 |
Iliac, Hyperplasia | |
Inguinal, Hyperplasia | 3 |
Mediastinal, Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 2 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | |
Hyperplasia | 3 2 2 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 3 3 3 |
Hyperplasia, Histiocytic | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + +|
Cyst | |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 142
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 5| 5| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 4| 8| 4| 1| 3| 1| 0| 0| 3| 3| 8| 9| 3| 3| 3| 3| 6| 6| 1| 1|
| 7| 7| 8| 8| 9| 7| 6| 9| 9| 0| 9| 1| 2| 0| 0| 3| 6| 0| 0| 0| 9| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0100% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 3 3 2 3 3 2|
Hyperplasia | 2 2 |
Metaplasia, Cartilagenous | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Fat, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 |
Inflammation, Suppurative | 3 3 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | |
Acinus, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Nephropathy | 2 2 3 4 4 2 3 2 3 2 4 4 3 4 3 3 4 2 3 3|
Pigmentation | |
Renal Tubule, Hyperplasia | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 143
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 5| 5| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 4| 8| 4| 1| 3| 1| 0| 0| 3| 3| 8| 9| 3| 3| 3| 3| 6| 6| 1| 1|
| 7| 7| 8| 8| 9| 7| 6| 9| 9| 0| 9| 1| 2| 0| 0| 3| 6| 0| 0| 0| 9| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0100% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Muscularis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 144
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 6| 1| 9| 3| 2| 5| 5| 5| 5| | |
| 3| 6| 8| 8| 0| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0100% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 51 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 51 |
Angiectasis | | 6 1.8|
Congestion | | 1 2.0|
Degeneration, Cystic | 1 1 | 10 1.3|
Eosinophilic Focus | | 1 3.0|
Fatty Change | 3 3 | 17 2.1|
Focal Cellular Change | 2 1 | 13 1.2|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 3 2.3|
Hyperplasia, Multifocal | 2 3 | 22 2.5|
Infiltration Cellular, Mixed Cell | 3 | 10 2.2|
Inflammation, Focal | 2 | 20 2.0|
Necrosis, Focal | 1 | 3 1.0|
Thrombosis | | 2 2.0|
Bile Duct, Dilatation | | 1 3.0|
Bile Duct, Hyperplasia | 3 2 2 3 2 2 | 49 2.1|
Biliary Tract, Fibrosis | 2 2 1 2 1 2 | 47 1.8|
Centrilobular, Atrophy | 3 2 | 15 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + | 15 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 3 2.0|
Fat, Necrosis | | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 51 |
Atrophy, Focal | 2 2 | 14 1.9|
Cytoplasmic Alteration | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 145
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 6| 1| 9| 3| 2| 5| 5| 5| 5| | |
| 3| 6| 8| 8| 0| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0100% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 51 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic | | 4 3.0|
Mineralization | | 1 1.0|
Perforation | | 1 4.0|
Ulcer | | 2 3.5|
Mucosa, Hyperplasia, Papillary | 2 | 7 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 51 |
Edema | | 1 2.0|
Erosion | | 2 1.0|
Inflammation, Chronic | | 3 1.7|
Mineralization | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Focal Cellular Change | 2 | 11 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Mineralization | | 2 1.5|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
Hyperplasia | | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 146
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 6| 1| 9| 3| 2| 5| 5| 5| 5| | |
| 3| 6| 8| 8| 0| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0100% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | | 18 2.6|
Atrophy | 2 | 1 2.0|
Cyst | 1 | 3 1.3|
Pars Distalis, Hyperplasia, Focal | 2 | 7 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 51 |
Degeneration, Cystic | 1 | 4 1.0|
C-Cell, Hyperplasia | 2 | 2 2.0|
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 51 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 51 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 1 2 2 | 22 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 51 |
Edema | | 1 2.0|
Inflammation, Suppurative | 2 1 1 1 2 | 31 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 51 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 51 |
Artery, Inflammation, Chronic | | 1 1.0|
Germinal Epithelium, Degeneration | 3 3 3 | 14 3.0|
Interstitial Cell, Hyperplasia | | 11 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 51 |
Hypercellularity | | 2 3.0|
Myelofibrosis | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
Bronchial, Hyperplasia | | 1 2.0|
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia | | 1 3.0|
Mediastinal, Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 147
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 6| 1| 9| 3| 2| 5| 5| 5| 5| | |
| 3| 6| 8| 8| 0| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0100% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 2.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Angiectasis | | 2 2.5|
Cyst | | 1 3.0|
Hyperplasia | 2 | 9 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 51 |
Angiectasis | | 3 2.0|
Fibrosis | | 7 2.4|
Hematopoietic Cell Proliferation | 2 | 10 2.8|
Hyperplasia, Histiocytic | | 1 2.0|
Necrosis, Focal | 1 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 48 |
Cyst | | 2 2.0|
Ectopic Parathyroid Gland | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 49 |
Dilatation | | 12 2.3|
Hyperplasia | | 2 2.0|
Metaplasia, Cartilagenous | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Fat, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 51 |
Compression | | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 148
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 6| 1| 9| 3| 2| 5| 5| 5| 5| | |
| 3| 6| 8| 8| 0| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.0100% | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 51 |
Congestion | | 1 2.0|
Hemorrhage | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
Fungus | 2 | 9 2.0|
Inflammation, Suppurative | 2 1 | 13 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Degeneration | | 1 3.0|
Sclera, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Acinus, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 51 |
Cyst | | 1 3.0|
Nephropathy | 3 3 2 3 4 2 | 51 2.9|
Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 51 |
Inflammation, Chronic | | 1 2.0|
Muscularis, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 149
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 1| 6| 6| 9| 3| 1| 2| 6| 2| 3| 0| 4| 6| 2| 3| 7| 8| 0| 3| 3|
| 7| 5| 0| 0| 0| 4| 2| 8| 5| 1| 3| 5| 8| 9| 0| 1| 5| 1| 9| 0| 3| 1| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.00500% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Congestion | |
Degeneration, Cystic | 2 2 2 2 1 1 2 |
Fatty Change | 1 1 2 2 3 3 2 1 3 1 2 3 |
Focal Cellular Change | 2 2 2 2 1 1|
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia | 2 |
Hyperplasia, Multifocal | 2 2 2 2 3 2 2 2 2 4 3 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 2 2 2 1 2 2 2 2 2 1 2 1|
Mixed Cell Focus | |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 3 3 1 1 2 2 2 3 2 2 1 2 2 2 1 2 2 2 1 2 1|
Biliary Tract, Fibrosis | 2 2 2 2 2 2 1 1 2 2 2 2 2 2 1 2 2 1 2 1 2 1 2 1|
Centrilobular, Atrophy | 2 2 2 3 4 2 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | 3 |
Inflammation, Chronic | 3 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 1 2 1 2 1|
Cytoplasmic Alteration | 2 |
Acinar Cell, Hyperplasia | |
Duct, Dilatation | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic | 4 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 150
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 1| 6| 6| 9| 3| 1| 2| 6| 2| 3| 0| 4| 6| 2| 3| 7| 8| 0| 3| 3|
| 7| 5| 0| 0| 0| 4| 2| 8| 5| 1| 3| 5| 8| 9| 0| 1| 5| 1| 9| 0| 3| 1| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.00500% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
Perforation | |
Ulcer | 4 2 |
Mucosa, Hyperplasia, Papillary | 3 2 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Mineralization | 2 3 |
Epithelium, Degeneration, Hyaline | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Mesenteric Artery, Hypertrophy | 2 |
Mesenteric Artery, Inflammation, | |
Chronic | 2 2 2 |
Mesenteric Artery, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 2 2 2 1 2 2 1 1 1 2 |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 3 2 4 2 3 3 3 2 2 2 3 2 |
Cyst | 1 1 |
Hemorrhage | 4 4 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 151
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 1| 6| 6| 9| 3| 1| 2| 6| 2| 3| 0| 4| 6| 2| 3| 7| 8| 0| 3| 3|
| 7| 5| 0| 0| 0| 4| 2| 8| 5| 1| 3| 5| 8| 9| 0| 1| 5| 1| 9| 0| 3| 1| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.00500% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia | 2 |
Inflammation, Suppurative | 1 3 1 1 2 2 1 2 2 1 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia, Focal | 2 2 2 1|
Inflammation, Suppurative | 1 1 1 2 2 3 2 2 1 3 3 2 2 1 1 1 1 2 1 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Artery, Inflammation, Chronic | |
Germinal Epithelium, Degeneration | 4 3 3 3 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2 |
Mediastinal, Angiectasis | 2 |
Mediastinal, Hyperplasia | 2 |
Pancreatic, Angiectasis | 2 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | 1 2 3 2 3 |
Hematopoietic Cell Proliferation | 2 2 2 3 2|
Necrosis, Focal | 3 |
Trabecula, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + M + + + + + + + + M + +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 152
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 1| 6| 6| 9| 3| 1| 2| 6| 2| 3| 0| 4| 6| 2| 3| 7| 8| 0| 3| 3|
| 7| 5| 0| 0| 0| 4| 2| 8| 5| 1| 3| 5| 8| 9| 0| 1| 5| 1| 9| 0| 3| 1| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.00500% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Dilatation | 3 2 3 2 2 1 1 3 1 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 1 2 2 2 3 2 |
Inflammation, Suppurative | 2 2 1 3 1 2 2 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + +|
Cataract | 3 |
Retina, Degeneration | 4 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis, Focal | 2 |
Nephropathy | 3 3 2 3 3 2 2 4 2 4 2 2 4 4 4 2 3 2 4 3 2 2 4 3 2|
Renal Tubule, Hyperplasia | 1 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 153
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 0| 0| 1| 3| 0| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 5| 7| 3| 3|
| 7| 7| 8| 9| 9| 9| 5| 1| 5| 0| 1| 1| 1| 1| 1| 4| 6| 1| 1| 1| 8| 4| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.00500% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | 2 2 |
Degeneration, Cystic | 1 1 1 1 1 2 |
Fatty Change | 2 2 1 1 2 2 1 1 2 |
Focal Cellular Change | 2 1 1 1 2 2|
Hepatodiaphragmatic Nodule | 3 X 3 |
Hyperplasia | 3 |
Hyperplasia, Multifocal | 4 1 2 2 2 1 3 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Focal | 2 2 2 1 2 2 1 2 2 1 2 |
Mixed Cell Focus | 3 3 |
Necrosis, Focal | 1 |
Thrombosis | 1 |
Bile Duct, Hyperplasia | 2 3 2 2 2 1 2 2 1 2 2 3 2 1 2 1 2 2 2 3|
Biliary Tract, Fibrosis | 2 2 2 2 1 1 2 2 2 2 2 1 1 2 1 1 2 2 2|
Centrilobular, Atrophy | 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 3 1 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 2 1 1|
Cytoplasmic Alteration | |
Acinar Cell, Hyperplasia | 2 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
Page 154
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 0| 0| 1| 3| 0| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 5| 7| 3| 3|
| 7| 7| 8| 9| 9| 9| 5| 1| 5| 0| 1| 1| 1| 1| 1| 4| 6| 1| 1| 1| 8| 4| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.00500% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | |
Perforation | 3 |
Ulcer | 4 4 |
Mucosa, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | 2 2 |
Mineralization | |
Epithelium, Degeneration, Hyaline | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Hypertrophy | |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Mesenteric Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 1 1 2 2 1 |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 3 3 3 3 2 |
Cyst | 1 2 |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
C-Cell, Hyperplasia | 1 1 2 |
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 155
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 0| 0| 1| 3| 0| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 5| 7| 3| 3|
| 7| 7| 8| 9| 9| 9| 5| 1| 5| 0| 1| 1| 1| 1| 1| 4| 6| 1| 1| 1| 8| 4| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.00500% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 2 2 2 3 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia, Focal | 1 |
Inflammation, Suppurative | 3 3 4 3 2 3 1 1 2 1 2 2 3 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Artery, Inflammation, Chronic | 3 |
Germinal Epithelium, Degeneration | 3 3 3 3 3 3 3 3|
Interstitial Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Hyperplasia | 2 |
Pancreatic, Angiectasis | |
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 2 3 3 2 2|
Hematopoietic Cell Proliferation | |
Necrosis, Focal | |
Trabecula, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 156
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 7| 0| 0| 1| 3| 0| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 5| 7| 3| 3|
| 7| 7| 8| 9| 9| 9| 5| 1| 5| 0| 1| 1| 1| 1| 1| 4| 6| 1| 1| 1| 8| 4| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.00500% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + +|
Dilatation | 2 3 2 1 2 2 2 2 3 2 1 |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 |
Inflammation, Suppurative | 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 |
Necrosis, Focal | |
Nephropathy | 3 3 4 4 3 4 4 4 4 4 3 2 4 3 3 3 3 3 3 3|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 157
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 6| 1| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 7| 8| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.00500% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Parasite Metazoan | 2 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | 2 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 3 1.7|
Congestion | | 2 2.0|
Degeneration, Cystic | 2 | 14 1.5|
Fatty Change | | 21 1.8|
Focal Cellular Change | | 12 1.6|
Hepatodiaphragmatic Nodule | | 4 3.0|
Hyperplasia | | 2 2.5|
Hyperplasia, Multifocal | 2 | 19 2.3|
Infiltration Cellular, Mixed Cell | 1 | 4 1.5|
Inflammation, Focal | 1 | 24 1.7|
Mixed Cell Focus | | 2 3.0|
Necrosis, Focal | 1 | 2 1.0|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | 2 1 1 3 2 | 50 1.9|
Biliary Tract, Fibrosis | 2 1 1 3 2 | 48 1.7|
Centrilobular, Atrophy | 2 2 | 15 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 15 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 4 2.3|
Fat, Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy, Focal | 2 2 | 18 1.4|
Cytoplasmic Alteration | | 1 2.0|
Acinar Cell, Hyperplasia | | 1 2.0|
Duct, Dilatation | | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 158
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 6| 1| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 7| 8| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.00500% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lipocyte | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic | 3 | 7 3.0|
Mineralization | | 1 2.0|
Perforation | | 1 3.0|
Ulcer | | 4 3.5|
Mucosa, Hyperplasia, Papillary | 3 | 6 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Erosion | | 2 1.5|
Inflammation, Chronic | | 2 2.0|
Mineralization | 3 | 3 2.7|
Epithelium, Degeneration, Hyaline | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 4 |
Mesenteric Artery, Hypertrophy | | 1 2.0|
Mesenteric Artery, Inflammation, | | |
Chronic | | 4 2.0|
Mesenteric Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Focal Cellular Change | 1 1 2 2 | 22 1.5|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | 2 | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Angiectasis | 4 | 23 2.7|
Cyst | | 4 1.3|
Hemorrhage | | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 159
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 6| 1| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 7| 8| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.00500% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 4 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | 1 | 8 1.0|
C-Cell, Hyperplasia | | 4 1.3|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | 1 1 3 | 23 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia, Focal | | 5 1.6|
Inflammation, Suppurative | 2 1 3 2 2 | 42 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Hyperplasia | | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Germinal Epithelium, Degeneration | 3 3 | 14 3.1|
Interstitial Cell, Hyperplasia | | 9 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Myelofibrosis | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | | 3 2.0|
Mediastinal, Hyperplasia | | 2 2.0|
Pancreatic, Angiectasis | | 1 2.0|
Renal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Angiectasis | | 1 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 160
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 6| 1| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 7| 8| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.00500% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Angiectasis | | 1 2.0|
Fibrosis | 3 1 | 12 2.3|
Hematopoietic Cell Proliferation | | 5 2.2|
Necrosis, Focal | | 1 3.0|
Trabecula, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 46 |
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 48 |
Dilatation | 2 | 22 2.0|
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Cyst Epithelial Inclusion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | 1 | 12 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 2 1.5|
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Fungus | | 11 1.8|
Inflammation, Suppurative | | 13 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 161
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 6| 1| 3| 3| 5| 5| 5| 5| 5| | |
| 3| 7| 8| 0| 0| 7| 7| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.00500% | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 2 3.0|
Retina, Degeneration | | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Cyst | 2 2 | 5 1.8|
Necrosis, Focal | | 1 2.0|
Nephropathy | 3 3 4 2 3 | 50 3.1|
Renal Tubule, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 162
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 9| 1| 5| 6| 9| 2| 4| 3| 3| 3| 0| 9| 3| 3| 3| 9| 6| 3| 3| 3|
| 4| 2| 0| 5| 0| 6| 8| 2| 8| 0| 2| 5| 1| 1| 1| 5| 0| 2| 2| 2| 1| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0275% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 2 |
Congestion | |
Degeneration, Cystic | 2 1 2 2 1|
Fatty Change | 3 |
Focal Cellular Change | 1 1 1 1 1 2 1 1 1 1 3 1 |
Hepatodiaphragmatic Nodule | 2 |
Hyperplasia, Multifocal | 2 2 1 2 3 2 3 3 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 3 2 2 |
Inflammation, Focal | 2 2 2 2 2 2 2 2 2 2 |
Necrosis, Focal | 1 1 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 2 3 3 2 2 1 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Biliary Tract, Fibrosis | 2 2 2 2 1 1 1 2 2 1 1 2 2 2 1 2 2 2 2 2 2 2 2|
Centrilobular, Atrophy | 2 2 1 1 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + |
Angiectasis | |
Fibrosis | 2 |
Hemorrhage | 2 2 |
Inflammation, Chronic | 3 2 2 |
Fat, Necrosis | 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 1 1 1 |
Cytoplasmic Alteration | 2 |
Duct, Dilatation | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
Page 163
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 9| 1| 5| 6| 9| 2| 4| 3| 3| 3| 0| 9| 3| 3| 3| 9| 6| 3| 3| 3|
| 4| 2| 0| 5| 0| 6| 8| 2| 8| 0| 2| 5| 1| 1| 1| 5| 0| 2| 2| 2| 1| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0275% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia, Papillary | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 1 1 |
Mineralization | 2 |
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Thoracic, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 2 2 3 3 3|
Cyst | |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 2 2 1 |
Pigmentation | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Cyst | 2 |
Follicle, Hyperplasia, Macrophage | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 164
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 9| 1| 5| 6| 9| 2| 4| 3| 3| 3| 0| 9| 3| 3| 3| 9| 6| 3| 3| 3|
| 4| 2| 0| 5| 0| 6| 8| 2| 8| 0| 2| 5| 1| 1| 1| 5| 0| 2| 2| 2| 1| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0275% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 |
Dilatation | |
Ectopic Tissue | |
Hyperplasia | |
Inflammation, Suppurative | 2 2 1 4 1 1 4 1 1 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Focal | 1 1 |
Inflammation, Suppurative | 1 2 3 1 2 2 2 1 1 1 1 1 1 2 3 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Germinal Epithelium, Degeneration | 3 3 3 |
Interstitial Cell, Hyperplasia | 2 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia | 2 |
Mediastinal, Angiectasis | 2 |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia | |
Renal, Angiectasis | 3 |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 3 |
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 165
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 9| 1| 5| 6| 9| 2| 4| 3| 3| 3| 0| 9| 3| 3| 3| 9| 6| 3| 3| 3|
| 4| 2| 0| 5| 0| 6| 8| 2| 8| 0| 2| 5| 1| 1| 1| 5| 0| 2| 2| 2| 1| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0275% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 1 1 2 3 4 3 3 2 2|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 3 3 2 2 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic | |
Inflammation, Granulomatous | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 2 2 2 |
Inflammation, Suppurative | 2 1 2 2 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Mineralization | |
Nephropathy | 2 2 3 3 4 2 3 3 4 2 3 2 3 3 4 2 4 3 3 3 3 2 3 3 2|
_____________________________________________________________________________________________________________________|
Page 166
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 9| 1| 5| 6| 9| 2| 4| 3| 3| 3| 0| 9| 3| 3| 3| 9| 6| 3| 3| 3|
| 4| 2| 0| 5| 0| 6| 8| 2| 8| 0| 2| 5| 1| 1| 1| 5| 0| 2| 2| 2| 1| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0275% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
Page 167
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 2| 0| 2| 2| 5| 8| 2| 2| 2| 3| 2| 2| 2| 0| 4| 2| 6| 1|
| 7| 8| 9| 9| 9| 3| 7| 9| 0| 9| 0| 4| 5| 9| 9| 2| 3| 1| 9| 9| 1| 7| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0275% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Congestion | |
Degeneration, Cystic | 2 1 |
Fatty Change | 1 1 1 1 3 2 1 2 2 |
Focal Cellular Change | 1 2 1 1 2 |
Hepatodiaphragmatic Nodule | 3 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 3 |
Inflammation, Focal | 2 2 2 2 2 1 2 1 2 2 2 2 2 |
Necrosis, Focal | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 1 1 2 2 3 2 1 2 3 3 2 2 1 2 3 1 2 2 2 2 3 2|
Biliary Tract, Fibrosis | 1 2 1 1 1 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 2|
Centrilobular, Atrophy | 2 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Angiectasis | 2 |
Fibrosis | |
Hemorrhage | 3 |
Inflammation, Chronic | 1 1 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 |
Cytoplasmic Alteration | |
Duct, Dilatation | 1 1 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 3 |
Ulcer | 2 3 |
Mucosa, Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
Page 168
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 2| 0| 2| 2| 5| 8| 2| 2| 2| 3| 2| 2| 2| 0| 4| 2| 6| 1|
| 7| 8| 9| 9| 9| 3| 7| 9| 0| 9| 0| 4| 5| 9| 9| 2| 3| 1| 9| 9| 1| 7| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0275% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia, Papillary | 2 2 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Mineralization | 2|
Pigmentation, Focal | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 3 |
Thoracic, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Focal Cellular Change | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 2 2 2 1 2 3 3|
Cyst | |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Pigmentation | |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 1 2 |
Follicle, Hyperplasia, Macrophage | |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 169
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 2| 0| 2| 2| 5| 8| 2| 2| 2| 3| 2| 2| 2| 0| 4| 2| 6| 1|
| 7| 8| 9| 9| 9| 3| 7| 9| 0| 9| 0| 4| 5| 9| 9| 2| 3| 1| 9| 9| 1| 7| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0275% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 |
Dilatation | |
Ectopic Tissue | |
Hyperplasia | 2 |
Inflammation, Suppurative | 1 4 3 1 2 1 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Focal | |
Inflammation, Suppurative | 2 2 2 3 3 2 3 1 3 2 3 1 2 2 4 4|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Germinal Epithelium, Degeneration | 3 3 3 3 3|
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Myelofibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia | |
Mediastinal, Angiectasis | 3 2 3 2 |
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia | 1 |
Renal, Angiectasis | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia | 2 3 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 3|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 170
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 2| 0| 2| 2| 5| 8| 2| 2| 2| 3| 2| 2| 2| 0| 4| 2| 6| 1|
| 7| 8| 9| 9| 9| 3| 7| 9| 0| 9| 0| 4| 5| 9| 9| 2| 3| 1| 9| 9| 1| 7| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0275% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 2 3 1 1 1 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 3 |
Inflammation, Chronic | 1 2 3 |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | 2 |
Sebaceous Gland, Hyperplasia | 3 |
Subcutaneous Tissue, Abscess | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + M + + + + + + +|
Compression | 2 3|
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Macrophage | 1 1 1 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | 1 |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 2 2 |
Inflammation, Suppurative | 2 3 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Mineralization | 1 |
Nephropathy | 2 2 2 2 2 2 2 3 4 4 2 3 4 4 4 2 4 4 3 3 3 1 3 4|
_____________________________________________________________________________________________________________________|
Page 171
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 7| 6| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 2| 0| 2| 2| 5| 8| 2| 2| 2| 3| 2| 2| 2| 0| 4| 2| 6| 1|
| 7| 8| 9| 9| 9| 3| 7| 9| 0| 9| 0| 4| 5| 9| 9| 2| 3| 1| 9| 9| 1| 7| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0275% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 172
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 4| 0| 2| 9| 1| 5| 5| 5| 5| | |
| 0| 5| 8| 9| 7| 5| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0275% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 | 5 1.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Parasite Metazoan | 1 | 8 1.4|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 8 1.6|
Congestion | 3 | 1 3.0|
Degeneration, Cystic | | 7 1.6|
Fatty Change | 3 2 1 1 2 1 | 16 1.7|
Focal Cellular Change | 1 2 | 19 1.3|
Hepatodiaphragmatic Nodule | 2 | 4 2.3|
Hyperplasia, Multifocal | | 18 2.2|
Infiltration Cellular, Mixed Cell | 2 | 8 2.3|
Inflammation, Focal | 1 2 2 2 1 2 2 | 30 1.9|
Necrosis, Focal | 2 | 3 1.3|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | 2 2 2 3 1 2 2 2 2 | 58 2.0|
Biliary Tract, Fibrosis | 1 2 2 2 2 1 2 2 | 52 1.7|
Centrilobular, Atrophy | | 12 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 21 |
Angiectasis | | 1 2.0|
Fibrosis | | 1 2.0|
Hemorrhage | | 3 2.3|
Inflammation, Chronic | | 5 1.8|
Fat, Necrosis | | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 1 | 11 1.4|
Cytoplasmic Alteration | | 1 2.0|
Duct, Dilatation | | 2 1.0|
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 173
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 4| 0| 2| 9| 1| 5| 5| 5| 5| | |
| 0| 5| 8| 9| 7| 5| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0275% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | 3 | 4 2.5|
Ulcer | 2 | 3 2.3|
Mucosa, Atrophy, Focal | 2 | 1 2.0|
Mucosa, Hyperplasia, Papillary | 3 | 6 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 2 2.0|
Inflammation, Chronic | | 3 1.3|
Mineralization | | 2 2.0|
Pigmentation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 3 2.3|
Thoracic, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Focal Cellular Change | 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 59 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 4 3 | 20 2.6|
Cyst | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Focal Cellular Change | 1 1 | 2 1.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 9 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 174
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 4| 0| 2| 9| 1| 5| 5| 5| 5| | |
| 0| 5| 8| 9| 7| 5| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0275% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | 1 | 1 1.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 | 5 1.4|
Follicle, Cyst | | 3 1.7|
Follicle, Hyperplasia, Macrophage | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Spermatocele | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 4 2.5|
Dilatation | 3 | 1 3.0|
Ectopic Tissue | 3 | 1 3.0|
Hyperplasia | 2 | 2 2.0|
Inflammation, Suppurative | 2 1 1 1 1 | 24 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hyperplasia, Focal | | 2 1.0|
Inflammation, Suppurative | 1 3 1 2 1 2 1 | 40 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
Germinal Epithelium, Degeneration | 3 3 | 10 3.0|
Interstitial Cell, Hyperplasia | 2 2 | 17 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Myelofibrosis | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Deep Cervical, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | 2 | 6 2.3|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Hyperplasia | | 1 1.0|
Renal, Angiectasis | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 175
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 4| 0| 2| 9| 1| 5| 5| 5| 5| | |
| 0| 5| 8| 9| 7| 5| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0275% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Hyperplasia | 3 2 2 | 8 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | 2 | 3 2.7|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 9 2.6|
Hematopoietic Cell Proliferation | 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | 1 2 | 17 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis | | 2 3.0|
Inflammation, Chronic | | 3 2.0|
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | | 1 2.0|
Sebaceous Gland, Hyperplasia | | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 3 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | 3 2 | 10 2.4|
Hemorrhage | 2 | 3 2.7|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 176
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 4| 0| 2| 9| 1| 5| 5| 5| 5| | |
| 0| 5| 8| 9| 7| 5| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0275% | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia, Macrophage | | 3 1.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 1.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 9 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 1 | 11 1.9|
Inflammation, Suppurative | 1 1 1 1 | 17 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 3 2.3|
Mineralization | | 1 1.0|
Nephropathy | 4 4 3 3 3 2 2 2 2 2 | 59 2.8|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 177
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
0.0275% | 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 178
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 4| 4| 5| 3| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
0.0275% | 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
Inflammation, Chronic | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 179
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 4| 5| 6| 6| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 4| 8| 1| 3| 3| 9| 4| 6| 1| 3| 9| 9| 5| 7| 3| 2| 2| 3| 3| 3| 6| 4| 7| 3| 3|
| 5| 0| 1| 0| 0| 0| 1| 8| 1| 0| 8| 1| 6| 3| 0| 9| 9| 2| 2| 2| 6| 5| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0140% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | 1 |
Muscularis, Degeneration | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | 1 2 2 2 1 1 |
Muscularis, Degeneration | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Muscularis, Degeneration | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Congestion | 2 |
Degeneration, Cystic | 2 1 1 2 |
Fatty Change | 2 1 3 2 3 2 1 1 2 |
Focal Cellular Change | 1 1 1 1 2 2 1 1 1 2 2 |
Hepatodiaphragmatic Nodule | 2 3 |
Hyperplasia, Multifocal | 3 1 3 2 3 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2|
Inflammation, Focal | 1 1 1 2 1 2 1 1 1 1 2|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 3 1 2 1 1 2 3 2 2 2 4 1 2 2 2 1 2 1 1 2 2 3 1 2|
Biliary Tract, Fibrosis | 1 2 1 2 1 1 2 2 1 2 2 4 1 2 2 2 1 2 1 1 1 2 2 1 2|
Centrilobular, Atrophy | 2 1 2 2 2 2 2 2 1 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 3 1 1 2 1 1 1 |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 180
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 4| 5| 6| 6| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 4| 8| 1| 3| 3| 9| 4| 6| 1| 3| 9| 9| 5| 7| 3| 2| 2| 3| 3| 3| 6| 4| 7| 3| 3|
| 5| 0| 1| 0| 0| 0| 1| 8| 1| 0| 8| 1| 6| 3| 0| 9| 9| 2| 2| 2| 6| 5| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0140% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 3 |
Inflammation, Chronic | 3 3 3 |
Mineralization | |
Ulcer | 3 3 3 |
Mucosa, Hyperplasia, Papillary | 3 2 3 2 2 |
Muscularis, Degeneration | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | 1 1 |
Mineralization | |
Muscularis, Degeneration | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Degeneration | |
Aorta, Mineralization | |
Mesenteric Artery, Degeneration | |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Mesenteric Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 1 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 2 3 2 2 |
Cyst | 1 |
Hemorrhage | 4 |
Hyperplasia, Tubular | 2 |
Necrosis | |
Pars Distalis, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1|
C-Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
Page 181
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 4| 5| 6| 6| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 4| 8| 1| 3| 3| 9| 4| 6| 1| 3| 9| 9| 5| 7| 3| 2| 2| 3| 3| 3| 6| 4| 7| 3| 3|
| 5| 0| 1| 0| 0| 0| 1| 8| 1| 0| 8| 1| 6| 3| 0| 9| 9| 2| 2| 2| 6| 5| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0140% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Ductus Deferens | |
Degeneration | |
Mineralization | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + M + +|
Degeneration, Cystic | 2 3 |
Inflammation, Suppurative | 2 2 1 1 1 2 2 1 1 1 2 1 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Suppurative | 2 2 3 3 2 1 3 3 1 2 4 2 1 1 1 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Dilatation | |
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
Germinal Epithelium, Degeneration | 2 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
Page 182
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 4| 5| 6| 6| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 4| 8| 1| 3| 3| 9| 4| 6| 1| 3| 9| 9| 5| 7| 3| 2| 2| 3| 3| 3| 6| 4| 7| 3| 3|
| 5| 0| 1| 0| 0| 0| 1| 8| 1| 0| 8| 1| 6| 3| 0| 9| 9| 2| 2| 2| 6| 5| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0140% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 2 |
Necrosis, Focal | |
Artery, Degeneration | |
Artery, Mineralization | |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + M + + + + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 3 2 1 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Fibrosis | |
Hyperkeratosis | |
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | 2 4 |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Abscess | 2 |
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3|
Subcutaneous Tissue, Fat, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Degeneration | |
Diaphragm, Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 183
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 4| 5| 6| 6| 7| 5| 7| 7| 7| 7| 4| 6| 6| 7| 7|
DAY ON TEST | 4| 8| 1| 3| 3| 9| 4| 6| 1| 3| 9| 9| 5| 7| 3| 2| 2| 3| 3| 3| 6| 4| 7| 3| 3|
| 5| 0| 1| 0| 0| 0| 1| 8| 1| 0| 8| 1| 6| 3| 0| 9| 9| 2| 2| 2| 6| 5| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.0140% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | |
Bronchus, Degeneration | |
Bronchus, Mineralization | |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 1 2 |
Inflammation, Suppurative | 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Nephropathy | 3 3 3 3 4 2 3 3 4 3 2 2 4 3 3 2 4 3 3 3 2 3 3 3 3|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Inflammation, Chronic | 3 |
Necrosis | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 184
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 3| 5| 6| 6| 6| 7| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 8| 1| 3| 6| 1| 2| 2| 3| 4| 5| 6| 1| 2| 2| 7| 8| 1| 1|
| 7| 7| 8| 9| 9| 5| 2| 3| 4| 9| 0| 8| 9| 9| 9| 0| 3| 9| 8| 9| 4| 6| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0140% | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Parasite Metazoan | |
Muscularis, Degeneration | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M +|
Mineralization | 2 |
Parasite Metazoan | 2 |
Muscularis, Degeneration | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Muscularis, Degeneration | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Congestion | |
Degeneration, Cystic | 2 2 1 2|
Fatty Change | 1 2 2 1 |
Focal Cellular Change | 2 2 1 1 2 |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Multifocal | 2 2 2 3 2 2 3 3|
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 1 2 1 1 2 1 2 2 |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 2 1 2 3 2 3 2 2 1 2 1 1 2 2 2 2 3 3|
Biliary Tract, Fibrosis | 1 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 3|
Centrilobular, Atrophy | 2 2 1 2 2 3 2 2 2|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Hemorrhage | 3 |
Inflammation, Chronic | 2 2 2 |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 1 3 2 3 1 1|
Edema | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 185
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 3| 5| 6| 6| 6| 7| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 8| 1| 3| 6| 1| 2| 2| 3| 4| 5| 6| 1| 2| 2| 7| 8| 1| 1|
| 7| 7| 8| 9| 9| 5| 2| 3| 4| 9| 0| 8| 9| 9| 9| 0| 3| 9| 8| 9| 4| 6| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0140% | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Inflammation, Chronic | 3 2 |
Mineralization | 3 |
Ulcer | |
Mucosa, Hyperplasia, Papillary | 3 |
Muscularis, Degeneration | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 1 |
Mineralization | 3 |
Muscularis, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Aorta, Degeneration | 4 |
Aorta, Mineralization | 4 |
Mesenteric Artery, Degeneration | 3 |
Mesenteric Artery, Inflammation, | |
Chronic | 4 2 |
Mesenteric Artery, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Mineralization | 3 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 3 3 3 3 3 |
Cyst | 4 2 |
Hemorrhage | 3 |
Hyperplasia, Tubular | |
Necrosis | 4 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 2 |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 186
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 3| 5| 6| 6| 6| 7| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 8| 1| 3| 6| 1| 2| 2| 3| 4| 5| 6| 1| 2| 2| 7| 8| 1| 1|
| 7| 7| 8| 9| 9| 5| 2| 3| 4| 9| 0| 8| 9| 9| 9| 0| 3| 9| 8| 9| 4| 6| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0140% | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Ductus Deferens | + |
Degeneration | 4 |
Mineralization | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + +|
Degeneration, Cystic | 2 |
Inflammation, Suppurative | 1 3 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Inflammation, Suppurative | 1 3 2 2 4 1 1 4 1 3 2 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Dilatation | 2 |
Inflammation, Chronic | 1 |
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Germinal Epithelium, Degeneration | 3 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
_____________________________________________________________________________________________________________________|
Page 187
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 3| 5| 6| 6| 6| 7| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 8| 1| 3| 6| 1| 2| 2| 3| 4| 5| 6| 1| 2| 2| 7| 8| 1| 1|
| 7| 7| 8| 9| 9| 5| 2| 3| 4| 9| 0| 8| 9| 9| 9| 0| 3| 9| 8| 9| 4| 6| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0140% | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 3 3 2 |
Hematopoietic Cell Proliferation | 3 4 |
Necrosis, Focal | 2 |
Artery, Degeneration | 2 |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + +|
Dilatation | 2 2 1 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis | |
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Cyst | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Degeneration | 3 |
Diaphragm, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 188
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 3| 5| 6| 6| 6| 7| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 6| 7| 8| 1| 3| 6| 1| 2| 2| 3| 4| 5| 6| 1| 2| 2| 7| 8| 1| 1|
| 7| 7| 8| 9| 9| 5| 2| 3| 4| 9| 0| 8| 9| 9| 9| 0| 3| 9| 8| 9| 4| 6| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0140% | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Artery, Mineralization | 2 |
Bronchus, Degeneration | 2 |
Bronchus, Mineralization | 2 |
Mediastinum, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + M + + + + + + + +|
Fungus | 2 2 1 |
Inflammation, Suppurative | 3 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 1 3 4 3 3 2 2 2 3 3 3 4 4 3 2 3 2 3 4|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Necrosis | |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 189
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Mineralization | | 1 2.0|
Parasite Metazoan | 2 2 | 3 1.7|
Muscularis, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
Mineralization | | 1 2.0|
Parasite Metazoan | | 7 1.6|
Muscularis, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
Mineralization | | 1 2.0|
Muscularis, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 5 1.8|
Congestion | 2 | 2 2.0|
Degeneration, Cystic | 2 | 9 1.7|
Fatty Change | | 13 1.8|
Focal Cellular Change | 1 1 1 | 19 1.4|
Hepatodiaphragmatic Nodule | | 4 2.8|
Hyperplasia, Multifocal | 2 | 20 2.3|
Infiltration Cellular, Mixed Cell | 1 2 2 | 11 1.9|
Inflammation, Focal | 2 2 2 2 | 23 1.5|
Necrosis, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 2 1 2 | 50 1.9|
Biliary Tract, Fibrosis | 2 2 1 | 45 1.7|
Centrilobular, Atrophy | 2 | 20 1.9|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 16 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 4 2.0|
Fat, Necrosis | 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 190
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Focal | | 17 1.5|
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Edema | | 1 3.0|
Inflammation, Chronic | | 5 2.8|
Mineralization | | 1 3.0|
Ulcer | | 3 3.0|
Mucosa, Hyperplasia, Papillary | | 6 2.5|
Muscularis, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Edema | | 1 2.0|
Inflammation, Chronic | | 4 1.3|
Mineralization | | 1 3.0|
Muscularis, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 5 |
Aorta, Degeneration | | 1 4.0|
Aorta, Mineralization | | 1 4.0|
Mesenteric Artery, Degeneration | | 1 3.0|
Mesenteric Artery, Inflammation, | | |
Chronic | 2 | 4 2.5|
Mesenteric Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Degeneration | | 1 3.0|
Mineralization | | 1 3.0|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 49 |
Focal Cellular Change | 1 | 14 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 49 |
Hyperplasia | 1 | 13 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 50 |
Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 191
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Angiectasis | 2 2 | 15 2.5|
Cyst | | 3 2.3|
Hemorrhage | | 2 3.5|
Hyperplasia, Tubular | | 1 2.0|
Necrosis | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Degeneration, Cystic | | 9 1.2|
C-Cell, Hyperplasia | 1 | 3 1.0|
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
Degeneration | | 1 4.0|
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 47 |
Degeneration, Cystic | | 3 2.3|
Inflammation, Suppurative | 2 1 1 | 28 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Hyperplasia, Focal | 1 1 | 3 1.0|
Inflammation, Suppurative | 1 1 2 1 1 | 36 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Degeneration | | 1 3.0|
Dilatation | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Artery, Inflammation, Chronic | | 1 1.0|
Germinal Epithelium, Degeneration | 3 | 8 2.9|
Interstitial Cell, Hyperplasia | 2 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 192
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Myelofibrosis | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Mediastinal, Angiectasis | | 1 2.0|
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 49 |
Angiectasis | | 2 2.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
Angiectasis | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Depletion Cellular | | 1 2.0|
Fibrosis | | 5 2.2|
Hematopoietic Cell Proliferation | | 4 3.0|
Necrosis, Focal | | 1 2.0|
Artery, Degeneration | | 1 2.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 49 |
Dilatation | 2 | 12 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
Subcutaneous Tissue, Abscess | | 1 2.0|
Subcutaneous Tissue, Cyst | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Subcutaneous Tissue, Fat, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 193
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Atrophy | | 1 2.0|
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Degeneration | | 1 3.0|
Diaphragm, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | 3 | 6 2.7|
Hemorrhage | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 3 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Macrophage | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Alveolar Epithelium, Degeneration | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Artery, Mineralization | | 1 2.0|
Bronchus, Degeneration | | 1 2.0|
Bronchus, Mineralization | | 1 2.0|
Mediastinum, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 49 |
Fungus | 2 | 7 1.6|
Inflammation, Suppurative | 2 | 9 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
Degeneration | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 194
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 3| 3| 3| 3| 5| 5| 5| 5| 5| | |
| 4| 8| 0| 0| 0| 7| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | A |
0.0140% | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Cyst | | 3 2.0|
Nephropathy | 2 3 4 4 3 | 49 2.9|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Hemorrhage | | 2 3.5|
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 195
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 5| 5| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 7| 5| 5| 5| 6| 6|
DAY ON TEST | 4| 9| 6| 2| 2| 9| 6| 9| 7| 2| 9| 2| 2| 8| 1| 7| 7| 9| 2| 2| 0| 4| 8| 1| 1|
| 0| 1| 8| 9| 9| 3| 9| 6| 5| 9| 0| 5| 6| 0| 6| 5| 5| 0| 0| 9| 3| 7| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.00700% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 3 |
Degeneration, Cystic | 1 1 1|
Fatty Change | 3 3 3 1 1 2 3 3 3 |
Fibrosis, Focal | |
Focal Cellular Change | 1 1 1 1|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 3|
Hyperplasia | 2 |
Hyperplasia, Multifocal | 2 2 1 1 1 1 2 2|
Hypertrophy, Focal | |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 |
Inflammation, Focal | 1 2 2 2 2 1 1 |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 1 2 2 1 2 1 1 2 2 2 1 1 2 1 3 2 2|
Biliary Tract, Fibrosis | 2 2 2 2 2 1 1 1 1 2 1 1 2 2 2 1 1 2 2 1 1 1 2|
Centrilobular, Atrophy | 4 2 2 2 3 2 2 2 2 2 2 2 1|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 2 2 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 3 2 1 1 2 1 1 2 1 2 1|
Edema | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 196
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 5| 5| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 7| 5| 5| 5| 6| 6|
DAY ON TEST | 4| 9| 6| 2| 2| 9| 6| 9| 7| 2| 9| 2| 2| 8| 1| 7| 7| 9| 2| 2| 0| 4| 8| 1| 1|
| 0| 1| 8| 9| 9| 3| 9| 6| 5| 9| 0| 5| 6| 0| 6| 5| 5| 0| 0| 9| 3| 7| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.00700% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 3 |
Inflammation, Chronic | 3 3 3 3 |
Mineralization | |
Perforation | |
Ulcer | 1 3 2 3 3 |
Mucosa, Hyperplasia, Papillary | 2 3 2 2 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 3 |
Mineralization | 3 2 |
Mucosa, Degeneration | 3 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Tongue | |
Epithelium, Developmental | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hyperplasia | 1 1 2 1 1 2 1 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 3 2 2 2|
Cyst | 1 2|
Hemorrhage | 3|
_____________________________________________________________________________________________________________________|
Page 197
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 5| 5| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 7| 5| 5| 5| 6| 6|
DAY ON TEST | 4| 9| 6| 2| 2| 9| 6| 9| 7| 2| 9| 2| 2| 8| 1| 7| 7| 9| 2| 2| 0| 4| 8| 1| 1|
| 0| 1| 8| 9| 9| 3| 9| 6| 5| 9| 0| 5| 6| 0| 6| 5| 5| 0| 0| 9| 3| 7| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.00700% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Tubular | 2 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1|
C-Cell, Hyperplasia | |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Necrosis, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 1 2 1 2 1 1 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Suppurative | 1 1 4 2 2 2 1 2 2 2 3 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 1 |
Artery, Inflammation, Chronic | 3 |
Germinal Epithelium, Degeneration | 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia | 3 |
Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Angiectasis | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia | 2 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 198
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 5| 5| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 7| 5| 5| 5| 6| 6|
DAY ON TEST | 4| 9| 6| 2| 2| 9| 6| 9| 7| 2| 9| 2| 2| 8| 1| 7| 7| 9| 2| 2| 0| 4| 8| 1| 1|
| 0| 1| 8| 9| 9| 3| 9| 6| 5| 9| 0| 5| 6| 0| 6| 5| 5| 0| 0| 9| 3| 7| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.00700% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 2 2 2|
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Histiocytic, Lymphoid | |
Necrosis, Focal | |
Pigmentation | |
Capsule, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M M + + + M + + + + M + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 2 1 1 |
Hemorrhage | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fracture Healed | |
Hyperostosis | 3 |
Cartilage, Hyperplasia | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 3 |
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 199
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 5| 5| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 7| 5| 5| 5| 6| 6|
DAY ON TEST | 4| 9| 6| 2| 2| 9| 6| 9| 7| 2| 9| 2| 2| 8| 1| 7| 7| 9| 2| 2| 0| 4| 8| 1| 1|
| 0| 1| 8| 9| 9| 3| 9| 6| 5| 9| 0| 5| 6| 0| 6| 5| 5| 0| 0| 9| 3| 7| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.00700% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 2 4 |
Mediastinum, Angiectasis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Fungus | 2 2 2 2 2 2|
Hemorrhage | |
Hyperplasia, Squamous | |
Inflammation, Suppurative | 3 2 2 1 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + I |
Atrophy | 3 |
Cataract | 4 |
Anterior Chamber, Inflammation, Acute| |
Cornea, Inflammation, Acute | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hydronephrosis | |
Nephropathy | 2 3 3 4 3 3 1 3 4 3 4 4 4 4 3 3 3 4 4 3 2 3 2 3 3|
Renal Tubule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 200
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 5| 6| 6| 7| 5| 6| 6| 7| 7| 0| 4| 5| 6| 6| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 0| 1| 5| 1| 2| 7| 7| 2| 3| 5| 9| 9| 1| 3| 3| 5| 6| 1| 3|
| 7| 8| 8| 9| 9| 5| 6| 4| 4| 8| 3| 6| 6| 1| 0| 4| 0| 7| 9| 8| 5| 3| 8| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.00700% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Congestion | |
Degeneration, Cystic | 2 1 1 1 2 |
Fatty Change | 1 4 3 2 2 2 1|
Fibrosis, Focal | 1 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 2 2 3 |
Hyperplasia | |
Hyperplasia, Multifocal | 3 2 1 2 1 |
Hypertrophy, Focal | 3 |
Infiltration Cellular, Mixed Cell | 1 2 2 |
Inflammation, Focal | 2 2 2 1 1 1 1 1 1 1|
Necrosis, Focal | 2 |
Thrombosis | 1 |
Bile Duct, Hyperplasia | 1 2 2 3 2 2 2 1 1 2 2 1 2 3 2 2 1 2 2|
Biliary Tract, Fibrosis | 1 2 2 2 1 2 2 2 1 1 2 1 2 1 2 |
Centrilobular, Atrophy | 2 2 3 2 4 2 |
Centrilobular, Necrosis | 4 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | 2 3 3 2 |
Fat, Necrosis | 1 1 3 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 201
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 5| 6| 6| 7| 5| 6| 6| 7| 7| 0| 4| 5| 6| 6| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 0| 1| 5| 1| 2| 7| 7| 2| 3| 5| 9| 9| 1| 3| 3| 5| 6| 1| 3|
| 7| 8| 8| 9| 9| 5| 6| 4| 4| 8| 3| 6| 6| 1| 0| 4| 0| 7| 9| 8| 5| 3| 8| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.00700% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Inflammation, Chronic | 3 4 3 3 1 3|
Mineralization | 2 |
Perforation | 4|
Ulcer | 3 4 4 4 4|
Mucosa, Hyperplasia, Papillary | 2 3 3 4 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 1 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 2 |
Mineralization | 3 |
Mucosa, Degeneration | 3 |
Mucosa, Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Developmental | |
Malformation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I + + + + + + +|
Angiectasis | 3 2 2 4|
Cyst | 3 |
Hemorrhage | 2|
_____________________________________________________________________________________________________________________|
Page 202
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 5| 6| 6| 7| 5| 6| 6| 7| 7| 0| 4| 5| 6| 6| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 0| 1| 5| 1| 2| 7| 7| 2| 3| 5| 9| 9| 1| 3| 3| 5| 6| 1| 3|
| 7| 8| 8| 9| 9| 5| 6| 4| 4| 8| 3| 6| 6| 1| 0| 4| 0| 7| 9| 8| 5| 3| 8| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.00700% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Tubular | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 1 4 1 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Suppurative | 1 2 3 2 3 1 3 2 1 2 2 3 3 1 2 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | |
Artery, Inflammation, Chronic | 2 2|
Germinal Epithelium, Degeneration | 3 4 |
Interstitial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 3 3 |
Hyperplasia | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Angiectasis | 3 3 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia | |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
_____________________________________________________________________________________________________________________|
Page 203
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 5| 6| 6| 7| 5| 6| 6| 7| 7| 0| 4| 5| 6| 6| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 0| 1| 5| 1| 2| 7| 7| 2| 3| 5| 9| 9| 1| 3| 3| 5| 6| 1| 3|
| 7| 8| 8| 9| 9| 5| 6| 4| 4| 8| 3| 6| 6| 1| 0| 4| 0| 7| 9| 8| 5| 3| 8| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.00700% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Histiocytic, Lymphoid | |
Necrosis, Focal | 3 |
Pigmentation | 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + +|
Dilatation | 2 3 2 3|
Hemorrhage | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Inflammation, Chronic | 3|
Epidermis, Hyperplasia | 3|
Sebaceous Gland, Hyperplasia | 3|
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fracture Healed | 3 |
Hyperostosis | |
Cartilage, Hyperplasia | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 204
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 5| 6| 6| 7| 5| 6| 6| 7| 7| 0| 4| 5| 6| 6| 4| 6| 6| 7| 7|
DAY ON TEST | 5| 5| 5| 5| 5| 8| 0| 1| 5| 1| 2| 7| 7| 2| 3| 5| 9| 9| 1| 3| 3| 5| 6| 1| 3|
| 7| 8| 8| 9| 9| 5| 6| 4| 4| 8| 3| 6| 6| 1| 0| 4| 0| 7| 9| 8| 5| 3| 8| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.00700% | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia, Macrophage | 3 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Granulomatous | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
Mediastinum, Angiectasis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Fungus | 2 2 2 1 2 3 2 3 2|
Hemorrhage | |
Hyperplasia, Squamous | 3 |
Inflammation, Suppurative | 2 2 2 1 3 3 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cataract | 3 |
Anterior Chamber, Inflammation, Acute| |
Cornea, Inflammation, Acute | |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 2|
Hydronephrosis | 3 |
Nephropathy | 2 2 3 4 4 2 3 4 4 3 2 3 4 3 2 3 2 4 3|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 205
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 51 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 51 |
Parasite Metazoan | | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 51 |
Parasite Metazoan | | 7 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 51 |
Angiectasis | 2 | 4 2.0|
Congestion | | 2 3.0|
Degeneration, Cystic | 1 1 1 | 11 1.2|
Fatty Change | | 16 2.3|
Fibrosis, Focal | | 1 1.0|
Focal Cellular Change | 2 | 6 1.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | 3 | 5 2.6|
Hyperplasia | | 1 2.0|
Hyperplasia, Multifocal | | 13 1.6|
Hypertrophy, Focal | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 | 10 1.9|
Inflammation, Focal | 1 1 2 | 20 1.4|
Necrosis, Focal | | 1 2.0|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 1 2 2 | 49 1.8|
Biliary Tract, Fibrosis | 1 1 1 2 2 | 43 1.5|
Centrilobular, Atrophy | | 19 2.3|
Centrilobular, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 25 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 3 2 | 8 2.4|
Fat, Necrosis | 2 | 8 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 51 |
Atrophy, Focal | 1 | 16 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 206
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 51 |
Edema | | 1 3.0|
Inflammation, Chronic | 3 | 11 2.9|
Mineralization | | 1 2.0|
Perforation | 4 | 2 4.0|
Ulcer | 4 | 11 3.2|
Mucosa, Hyperplasia, Papillary | 3 3 | 14 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 51 |
Edema | 2 | 1 2.0|
Erosion | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 3 2.7|
Mineralization | 2 | 4 2.5|
Mucosa, Degeneration | 2 | 3 2.7|
Mucosa, Hyperplasia | 2 | 5 2.4|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Developmental | | |
Malformation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Aorta, Mineralization | | 2 3.5|
Mesenteric Artery, Inflammation, | | |
Chronic | 2 | 3 2.3|
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
Mineralization | | 1 2.0|
Thrombosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Atrophy | 3 | 1 3.0|
Focal Cellular Change | 1 | 7 1.0|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 207
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Atrophy | 3 | 1 3.0|
Hyperplasia | 1 | 15 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
Hyperplasia | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Angiectasis | 2 3 3 3 | 15 2.6|
Cyst | | 3 2.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Tubular | | 1 2.0|
Pars Distalis, Focal Cellular Change | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A | 50 |
Degeneration, Cystic | 1 1 | 8 1.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | 1 | 2 1.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 51 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 51 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 2 1 2 | 17 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 51 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Suppurative | 1 2 1 4 3 | 36 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 51 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 51 |
Hemorrhage | | 1 1.0|
Mineralization | | 1 1.0|
Artery, Inflammation, Chronic | 2 | 4 2.3|
Germinal Epithelium, Degeneration | 3 | 7 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 208
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 51 |
Hypercellularity | | 4 3.0|
Hyperplasia | | 1 3.0|
Myelofibrosis | 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
Inguinal, Hyperplasia | 3 | 1 3.0|
Mediastinal, Angiectasis | 2 | 6 2.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia | | 1 2.0|
Renal, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Angiectasis | 2 | 3 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia | 2 | 7 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 51 |
Fibrosis | 1 3 | 8 2.0|
Hematopoietic Cell Proliferation | 2 2 2 | 7 2.1|
Hyperplasia, Histiocytic, Lymphoid | 4 | 1 4.0|
Necrosis, Focal | | 1 3.0|
Pigmentation | | 1 2.0|
Capsule, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 44 |
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Dilatation | 2 3 2 | 13 2.2|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Cyst Epithelial Inclusion | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Epidermis, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 209
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Sebaceous Gland, Hyperplasia | | 1 3.0|
Subcutaneous Tissue, Fibrosis | 2 2 | 2 2.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
Developmental Malformation | 4 | 1 4.0|
Fracture Healed | | 1 3.0|
Hyperostosis | 4 | 2 3.5|
Cartilage, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 51 |
Compression | 2 | 8 2.6|
Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 51 |
Congestion | | 1 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Macrophage | 2 | 2 2.5|
Infiltration Cellular, Mixed Cell | 3 | 3 2.3|
Inflammation, Granulomatous | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 1 | 7 2.1|
Mediastinum, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
Exudate | 4 | 1 4.0|
Fungus | 1 | 16 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Suppurative | 1 1 | 19 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Atrophy | | 1 3.0|
Cataract | | 2 3.5|
Anterior Chamber, Inflammation, Acute| 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 210
NTP Experiment-Test: 05089-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 16:21:47
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 4| 4| 4| | |
DAY ON TEST | 2| 3| 6| 1| 1| 0| 5| 5| 5| 5| | |
| 7| 9| 8| 9| 9| 6| 7| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.00700% | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Inflammation, Acute | 1 | 1 1.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A | 50 |
Cyst | 3 2 | 8 2.3|
Hydronephrosis | | 1 3.0|
Nephropathy | 3 2 4 4 4 | 49 3.1|
Renal Tubule, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Bulbourethral Gland, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 51 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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