TR 393 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
SODIUM FLUORIDE
NTP Experiment-Test: 05131-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7681-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 50 70 70 99
Scheduled Sacrifice 20 18 20 19
Early Deaths
Natural Death 13 7 5 7 16
Moribund Sacrifice 14 6 9 9 12
Survivors
Terminal Sacrifice 53 8 38 32 51
Natural Death 2 1
Special Control 29
Animals Examined Microscopically 100 42 62 63 99
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (99) (42) (60) (60) (99)
Inflammation, Chronic Active 1 (2%)
Gallbladder (99) (40) (59) (58) (98)
Cyst 1 (2%)
Mineralization 1 (1%)
Artery, Necrosis, Fibrinoid 1 (2%)
Intestine Small, Duodenum (100) (42) (60) (58) (98)
Inflammation, Chronic Active 2 (3%) 2 (2%)
Intestine Small, Ileum (98) (42) (60) (59) (97)
Lymphoid Tissue, Hyperplasia 1 (2%)
Intestine Small, Jejunum (100) (42) (60) (59) (97)
Inflammation, Chronic Active 1 (1%)
Lymphoid Tissue, Hyperplasia 3 (3%)
Liver (100) (42) (60) (60) (99)
Angiectasis 1 (2%)
Basophilic Focus 2 (2%) 6 (14%) 1 (2%) 3 (5%)
Clear Cell Focus 3 (3%) 2 (5%) 2 (3%) 2 (3%) 3 (3%)
Eosinophilic Focus 23 (23%) 4 (10%) 22 (37%) 11 (18%) 12 (12%)
Hematopoietic Cell Proliferation 6 (6%) 2 (5%) 3 (5%) 3 (5%) 6 (6%)
Hepatodiaphragmatic Nodule 1 (2%) 1 (2%) 1 (1%)
Inflammation, Chronic Active 2 (2%) 1 (2%) 3 (3%)
Leukocytosis 2 (5%)
Mineralization 1 (2%)
Necrosis, Coagulative 7 (7%) 4 (10%) 4 (7%) 9 (15%) 3 (3%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 6 (6%) 5 (12%) 4 (7%) 7 (12%) 6 (6%)
Artery, Necrosis, Fibrinoid 1 (2%)
Bile Duct, Cyst 1 (1%) 1 (2%) 1 (2%)
Mesentery (28) (6) (16) (18) (28)
Hemorrhage 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (17%) 1 (4%)
Inflammation, Necrotizing 24 (86%) 3 (50%) 13 (81%) 14 (78%) 15 (54%)
Mineralization 11 (39%) 7 (44%) 5 (28%) 4 (14%)
Artery, Necrosis, Fibrinoid 1 (6%)
Pancreas (100) (42) (60) (59) (98)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%)
Acinus, Atrophy 3 (3%) 4 (7%) 2 (2%)
Acinus, Hyperplasia 2 (2%)
Duct, Ectasia 1 (2%) 3 (3%)
Salivary Glands (99) (41) (60) (60) (99)
Duct, Ectasia 1 (1%)
Stomach, Forestomach (100) (42) (60) (59) (98)
Acanthosis 5 (5%) 6 (10%) 5 (8%) 3 (3%)
Diverticulum 1 (1%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (3%) 1 (2%) 5 (8%) 3 (5%) 5 (5%)
Stomach, Glandular (100) (42) (60) (59) (98)
Cyst 1 (2%)
Erosion 1 (1%) 2 (5%) 3 (3%)
Hyperplasia 2 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 4 (4%)
Tooth (90) (42) (60) (60) (89)
Dentine, Incisor, Dysplasia 34 (38%) 1 (2%) 21 (35%) 23 (38%) 24 (27%)
Dentine, Incisor, Necrosis 2 (3%) 2 (2%)
Incisor, Lower, Dysplasia 1 (2%)
Incisor, Ameloblast, Atrophy 1 (1%) 1 (2%) 3 (3%)
Incisor, Ameloblast, Degeneration 1 (2%)
Peridontal Tissue, Incisor, Inflammation,
Suppurative 1 (2%)
Peridontal Tissue, Incisor, Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Artery, Necrosis, Fibrinoid 1 (100%)
Heart (99) (41) (60) (60) (99)
Cardiomyopathy, Chronic 1 (1%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (1%)
Artery, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (99) (42) (60) (60) (99)
Accessory Adrenal Cortical Nodule 3 (3%) 1 (1%)
Cyst 1 (2%) 1 (1%)
Cytoplasmic Alteration 1 (1%)
Degeneration, Fatty 2 (2%) 3 (5%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (1%) 1 (2%) 2 (2%)
Hyperplasia 3 (3%) 1 (2%) 1 (2%) 2 (2%)
Hypertrophy 6 (6%) 1 (2%) 4 (7%)
Capsule, Spindle Cell, Hyperplasia 1 (1%) 1 (2%) 3 (5%) 1 (1%)
Adrenal Gland, Medulla (96) (42) (60) (60) (98)
Hyperplasia 1 (1%) 1 (2%)
Hypertrophy 1 (1%)
Parathyroid Gland (92) (37) (59) (57) (92)
Cyst 1 (1%) 1 (2%) 1 (1%)
Hyperplasia 1 (3%)
Pituitary Gland (100) (41) (59) (61) (97)
Craniopharyngeal Duct, Pars Distalis, Cyst 1 (2%)
Craniopharyngeal Duct, Pars Distalis,
Inflammation, Suppurative 1 (2%)
Pars Distalis, Cyst 5 (5%) 1 (2%) 4 (7%) 2 (2%)
Pars Distalis, Hyperplasia 16 (16%) 1 (2%) 20 (34%) 16 (26%) 25 (26%)
Thyroid Gland (100) (42) (60) (60) (99)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%) 2 (3%) 2 (2%)
Ultimobranchial Cyst 1 (1%) 1 (2%) 1 (2%) 3 (3%)
Follicle, Cyst 1 (1%)
Follicular Cell, Hyperplasia 30 (30%) 8 (19%) 27 (45%) 24 (40%) 33 (33%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2) (2) (3)
Pigmentation, Melanin 1 (50%)
Duct, Dilatation 1 (50%) 1 (50%)
Ovary (98) (41) (57) (58) (98)
Atrophy 63 (64%) 14 (34%) 38 (67%) 39 (67%) 59 (60%)
Cyst 24 (24%) 12 (29%) 25 (44%) 16 (28%) 25 (26%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (1%) 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (1%)
Thrombosis 2 (4%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Uterus (100) (42) (60) (60) (99)
Angiectasis 1 (1%) 1 (1%)
Dilatation 13 (13%) 11 (26%) 14 (23%) 6 (10%) 14 (14%)
Hyperplasia, Cystic, Glandular 81 (81%) 34 (81%) 54 (90%) 56 (93%) 81 (82%)
Inflammation, Necrotizing 1 (1%)
Inflammation, Suppurative 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (42) (62) (61) (99)
Femoral, Hyperplasia, Mast Cell 1 (1%)
Femoral, Myelofibrosis 34 (34%) 5 (12%) 34 (55%) 34 (56%) 53 (54%)
Humerus, Myelofibrosis 28 (28%) 7 (17%) 27 (44%) 26 (43%) 47 (47%)
Mandible, Myelofibrosis 1 (1%) 1 (1%)
Maxilla, Hyperplasia, Mast Cell 1 (1%)
Maxilla, Myelofibrosis 19 (19%) 3 (7%) 20 (32%) 21 (34%) 44 (44%)
Thoracic, Vertebra, Myelofibrosis 61 (61%) 20 (48%) 50 (81%) 49 (80%) 74 (75%)
Tibia, Myelofibrosis 14 (14%) 3 (7%) 16 (26%) 9 (15%) 26 (26%)
Lymph Node (100) (42) (60) (60) (99)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Renal, Sinus, Ectasia 1 (2%)
Lymph Node, Mandibular (96) (42) (60) (56) (98)
Hyperplasia, Lymphoid 2 (2%)
Lymph Node, Mesenteric (99) (40) (57) (57) (94)
Hyperplasia, Plasma Cell 1 (1%)
Sinus, Ectasia 1 (1%) 1 (2%) 1 (2%)
Spleen (99) (42) (60) (59) (99)
Depletion Lymphoid 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 20 (20%) 10 (24%) 15 (25%) 15 (25%) 20 (20%)
Hemorrhage 1 (1%)
Hyperplasia, Lymphoid 10 (10%) 3 (7%) 7 (12%) 7 (12%) 11 (11%)
Thymus (96) (42) (56) (55) (92)
Cyst 4 (4%) 3 (7%) 6 (11%) 4 (7%) 6 (7%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 2 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Thymocyte, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (98) (41) (59) (60) (99)
Hyperplasia, Cystic 8 (8%) 7 (17%) 8 (14%) 8 (13%) 7 (7%)
Inflammation, Chronic Active 1 (2%)
Skin (100) (42) (60) (60) (99)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Acanthosis 1 (1%)
Alopecia 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (1%)
Inflammation, Chronic Active 2 (2%) 2 (3%) 1 (2%) 2 (2%)
Mineralization 1 (1%)
Artery, Necrosis, Fibrinoid 1 (2%)
Hair Follicle, Cyst 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (90) (42) (60) (60) (89)
Femur, Osteosclerosis 1 (1%)
Humerus, Osteosclerosis 2 (2%) 2 (2%)
Humerus, Periosteum, Proliferation, Focal 1 (2%)
Intervertebral Disc, Degeneration 14 (16%) 2 (5%) 13 (22%) 8 (13%) 16 (18%)
Mandible, Inflammation, Suppurative 1 (2%)
Periosteum, Tibia, Proliferation, Focal 1 (1%)
Periosteum, Maxilla, Proliferation, Focal 1 (2%)
Rib, Cartilage, Degeneration 1 (2%) 1 (2%) 1 (1%)
Rib, Cartilage, Necrosis 1 (1%)
Thoracic, Vertebra, Osteosclerosis 1 (1%) 1 (2%) 3 (3%)
Tibia, Osteosclerosis 1 (2%) 2 (2%)
Skeletal Muscle (12) (1) (1) (11)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (42) (60) (60) (99)
Compression 3 (3%) 2 (3%) 2 (3%) 1 (1%)
Hydrocephalus 3 (3%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (1%)
Artery, Necrosis, Fibrinoid 1 (2%)
Neuron, Necrosis 1 (2%)
White Matter, Degeneration 1 (2%)
Peripheral Nerve (1) (1) (3) (1)
Sciatic, Degeneration 1 (100%) 1 (33%)
Spinal, Degeneration 1 (33%)
Spinal Cord (1) (1) (3) (1)
White Matter, Degeneration 1 (33%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (42) (60) (60) (99)
Inflammation, Chronic Active 3 (3%) 1 (2%) 4 (7%) 1 (2%) 3 (3%)
Leukocytosis 2 (5%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (2%) 2 (5%) 3 (5%) 1 (2%)
Nose (100) (42) (60) (60) (99)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (1%) 1 (2%) 3 (5%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (1)
Middle Ear, Inflammation, Suppurative 1 (100%)
Eye (1) (1) (2) (3) (1)
Inflammation, Chronic Active 1 (100%)
Phthisis Bulbi 1 (50%)
Cornea, Inflammation, Chronic Active 2 (67%)
Lens, Cataract 1 (50%)
Retina, Atrophy 1 (50%)
Harderian Gland (66) (36) (48) (45) (52)
Hyperplasia 1 (3%) 2 (4%)
Inflammation, Chronic Active 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (42) (60) (60) (99)
Atypia Cellular 1 (1%)
Cyst 1 (2%) 2 (3%) 1 (1%)
Hydronephrosis 1 (1%) 1 (2%)
Hypertrophy 1 (1%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (1%)
Mineralization 63 (63%) 22 (52%) 34 (57%) 26 (43%) 28 (28%)
Necrosis, Coagulative 1 (2%)
Nephropathy, Chronic 52 (52%) 12 (29%) 43 (72%) 29 (48%) 26 (26%)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Hyperplasia, Lymphoid 2 (2%)
Renal Tubule, Necrosis 3 (3%)
Urinary Bladder (100) (42) (60) (60) (97)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Necrotizing 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 99 50 70 70 100
Scheduled Sacrifice 20 20 19 20
Early Deaths
Natural Death 16 3 8 6 11
Moribund Sacrifice 5 9 3 8 4
Survivors
Natural Death 2
Terminal Sacrifice 56 18 39 37 65
Special Control 20
Animals Examined Microscopically 99 32 60 62 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (96) (32) (58) (59) (100)
Cyst 1 (3%)
Intestine Small, Duodenum (99) (32) (60) (59) (100)
Erosion 1 (2%)
Intussusception 1 (2%)
Intestine Small, Jejunum (99) (32) (60) (59) (100)
Lymphoid Tissue, Hyperplasia 2 (3%) 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (3%)
Liver (99) (32) (60) (61) (100)
Basophilic Focus 9 (9%) 1 (3%) 6 (10%) 2 (3%) 5 (5%)
Clear Cell Focus 36 (36%) 7 (22%) 27 (45%) 31 (51%) 48 (48%)
Clear Cell Focus, Multiple 1 (3%)
Cytologic Alterations 1 (1%) 1 (2%)
Eosinophilic Focus 9 (9%) 2 (6%) 9 (15%) 12 (20%) 6 (6%)
Fibrosis 1 (2%)
Hyperplasia 1 (1%) 2 (3%)
Inflammation, Chronic Active 2 (2%) 2 (6%) 7 (12%) 1 (2%)
Mineralization 1 (2%) 1 (1%)
Mixed Cell Focus 1 (2%) 2 (2%)
Necrosis, Coagulative 4 (4%) 3 (9%) 5 (8%) 4 (7%) 4 (4%)
Vacuolization Cytoplasmic 24 (24%) 13 (41%) 18 (30%) 17 (28%) 27 (27%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (10) (2) (5) (8) (4)
Inflammation, Chronic Active 1 (13%) 1 (25%)
Inflammation, Necrotizing 8 (80%) 1 (50%) 4 (80%) 6 (75%) 2 (50%)
Mineralization 1 (10%) 2 (40%) 2 (25%) 1 (25%)
Pancreas (98) (32) (60) (60) (100)
Inflammation, Chronic Active 1 (1%)
Acinus, Amyloid Deposition 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 3 (3%) 1 (2%) 1 (2%) 1 (1%)
Acinus, Inflammation, Chronic Active 1 (1%) 1 (2%)
Acinus, Necrosis, Coagulative 1 (2%)
Stomach, Forestomach (99) (32) (60) (60) (99)
Acanthosis 2 (2%) 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (1%)
Diverticulum 1 (3%) 1 (2%) 2 (2%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%)
Mineralization 1 (3%)
Stomach, Glandular (99) (32) (60) (60) (100)
Erosion 1 (1%) 1 (2%) 1 (2%) 2 (2%)
Inflammation, Chronic Active 1 (1%)
Mineralization 2 (2%) 2 (3%) 1 (2%) 4 (4%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Tooth (90) (32) (60) (60) (90)
Dentine, Incisor, Concretion 1 (1%)
Dentine, Incisor, Degeneration 1 (2%)
Dentine, Incisor, Dysplasia 69 (77%) 17 (53%) 52 (87%) 48 (80%) 82 (91%)
Dentine, Incisor, Necrosis 2 (2%) 2 (2%)
Gingiva, Incisor, Inflammation, Suppurative 1 (2%)
Incisor, Lower, Dysplasia 8 (9%) 6 (19%) 14 (23%) 17 (28%) 14 (16%)
Incisor, Ameloblast, Atrophy 42 (47%) 15 (47%) 29 (48%) 27 (45%) 50 (56%)
Peridontal Tissue, Incisor, Inflammation,
Suppurative 1 (2%) 1 (1%)
Pulp, Incisor, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1) (1) (2)
Inflammation, Chronic Active 1 (100%)
Aorta, Inflammation, Chronic Active 1 (100%) 1 (50%)
Mesenteric Artery, Inflammation, Chronic
Active 1 (33%) 1 (100%)
Mesenteric Artery, Necrosis, Fibrinoid 1 (33%)
Renal Artery, Inflammation, Chronic Active 1 (33%)
Thoracic, Artery, Inflammation, Chronic
Active 1 (100%)
Heart (99) (32) (60) (59) (100)
Cardiomyopathy, Chronic 2 (2%) 1 (2%) 1 (1%)
Mineralization 2 (6%)
Perivascular, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (99) (32) (60) (60) (100)
Accessory Adrenal Cortical Nodule 2 (2%) 1 (2%) 1 (1%)
Atrophy 1 (2%)
Cyst 2 (2%) 2 (3%) 1 (2%)
Hyperplasia 3 (3%) 1 (3%) 1 (2%) 4 (7%) 7 (7%)
Hypertrophy 34 (34%) 7 (22%) 16 (27%) 23 (38%) 32 (32%)
Bilateral, Capsule, Spindle Cell, Hyperplasia 1 (1%) 1 (3%) 1 (2%) 2 (2%)
Capsule, Spindle Cell, Hyperplasia 11 (11%) 1 (3%) 8 (13%) 10 (17%) 13 (13%)
Adrenal Gland, Medulla (96) (32) (60) (60) (99)
Hyperplasia 1 (2%) 1 (2%) 1 (1%)
Islets, Pancreatic (98) (32) (60) (60) (100)
Hyperplasia 13 (13%) 7 (22%) 7 (12%) 17 (28%) 15 (15%)
Parathyroid Gland (88) (30) (55) (55) (97)
Cyst 2 (2%) 1 (2%)
Pituitary Gland (91) (32) (59) (57) (93)
Pars Distalis, Cyst 2 (2%) 6 (10%) 5 (9%) 4 (4%)
Pars Distalis, Hyperplasia 3 (3%) 1 (2%) 2 (4%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (99) (32) (60) (60) (100)
Cyst 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Ultimobranchial Cyst 1 (3%) 2 (3%) 1 (1%)
Follicle, Cyst 1 (1%)
Follicular Cell, Hyperplasia 6 (6%) 1 (3%) 10 (17%) 6 (10%) 12 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (99) (32) (60) (60) (99)
Aspermia 1 (1%) 2 (2%)
Atrophy 2 (2%)
Granuloma Sperm 2 (2%) 2 (3%) 4 (4%)
Inflammation, Chronic Active 2 (2%) 1 (3%) 1 (2%) 1 (1%)
Mineralization 1 (2%) 2 (3%)
Duct, Dilatation 1 (1%)
Preputial Gland (57) (12) (40) (33) (55)
Atrophy 48 (84%) 11 (92%) 30 (75%) 27 (82%) 35 (64%)
Inflammation, Chronic Active 22 (39%) 5 (42%) 18 (45%) 14 (42%) 25 (45%)
Duct, Dilatation 51 (89%) 11 (92%) 36 (90%) 32 (97%) 47 (85%)
Prostate (99) (32) (60) (60) (99)
Atrophy 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 3 (3%) 1 (3%) 1 (2%) 1 (1%)
Seminal Vesicle (99) (32) (60) (60) (100)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (2%) 1 (3%) 2 (3%) 1 (2%) 1 (1%)
Testes (98) (31) (60) (60) (99)
Mineralization 1 (3%) 2 (3%)
Necrosis, Coagulative 1 (2%)
Seminiferous Tubule, Atrophy 2 (2%)
Seminiferous Tubule, Degeneration 2 (3%) 3 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (99) (32) (60) (60) (100)
Femoral, Myelofibrosis 1 (1%) 1 (2%) 5 (8%) 2 (2%)
Femoral, Necrosis, Coagulative 1 (1%)
Humerus, Myelofibrosis 1 (2%) 2 (3%)
Maxilla, Myelofibrosis 1 (1%) 2 (3%)
Thoracic, Vertebra, Myelofibrosis 1 (1%)
Tibia, Myelofibrosis 1 (2%)
Lymph Node (99) (32) (60) (60) (100)
Inguinal, Hyperplasia, Plasma Cell 1 (1%)
Renal, Sinus, Ectasia 1 (2%)
Lymph Node, Mandibular (98) (31) (60) (59) (100)
Hyperplasia, Plasma Cell 2 (3%)
Lymph Node, Mesenteric (94) (31) (59) (56) (92)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 4 (7%)
Inflammation, Chronic Active 1 (1%)
Thrombosis 1 (2%)
Spleen (99) (32) (60) (60) (100)
Atrophy 1 (2%) 2 (2%)
Hematopoietic Cell Proliferation 8 (8%) 3 (9%) 10 (17%) 7 (12%) 9 (9%)
Hyperplasia, Lymphoid 1 (1%)
Thymus (87) (28) (52) (45) (85)
Atrophy 2 (4%)
Cyst 11 (13%) 3 (11%) 13 (25%) 6 (13%) 11 (13%)
Hyperplasia, Lymphoid 1 (1%)
Inflammation, Chronic Active 1 (1%)
Thymocyte, Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (99) (31) (60) (60) (100)
Autolysis 1 (1%)
Inflammation, Chronic Active 2 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (89) (32) (60) (60) (90)
Calvarium, Hyperostosis 1 (1%)
Calvarium, Osteosclerosis, Focal 1 (2%)
Humerus, Osteosclerosis 1 (2%)
Humerus, Joint, Cartilage, Hyperplasia, Focal 1 (1%)
Intervertebral Disc, Degeneration 6 (7%) 2 (6%) 10 (17%) 6 (10%) 8 (9%)
Joint, Cartilage, Tibia, Degeneration 2 (2%)
Rib, Cartilage, Degeneration 1 (2%) 2 (2%)
Thoracic, Vertebra, Osteosclerosis 2 (2%) 1 (3%) 3 (3%)
Tibia, Fracture Healed 1 (3%)
Tibia, Osteosclerosis 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (99) (32) (60) (60) (100)
Infiltration Cellular, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Chronic Active 4 (4%) 2 (3%) 2 (3%) 4 (4%)
Leukocytosis 1 (1%) 1 (3%) 1 (1%)
Mineralization 1 (1%)
Pigmentation, Hemosiderin 1 (1%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 4 (4%) 4 (7%) 4 (7%) 3 (3%)
Bronchus, Dilatation 1 (2%)
Mediastinum, Mineralization 1 (1%)
Nose (99) (32) (60) (60) (100)
Inflammation, Chronic Active 1 (1%) 1 (3%) 2 (2%)
Nasolacrimal Duct, Hyperplasia, Squamous 1 (1%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (7%) 5 (8%) 2 (3%) 2 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05131-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 08:28:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (2) (1)
Middle Ear, Inflammation, Suppurative 1 (50%)
Eye (5)
Phthisis Bulbi 1 (20%)
Cornea, Inflammation, Chronic Active 2 (40%)
Cornea, Mineralization 1 (20%)
Lens, Cataract 2 (40%)
Retina, Atrophy 1 (20%)
Harderian Gland (85) (27) (49) (52) (75)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (99) (32) (60) (60) (100)
Cyst 17 (17%) 4 (13%) 10 (17%) 13 (22%) 11 (11%)
Hydronephrosis 2 (6%) 1 (2%)
Inflammation, Chronic Active 2 (2%) 1 (3%) 2 (3%) 1 (1%)
Inflammation, Necrotizing 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 75 (76%) 28 (88%) 47 (78%) 44 (73%) 73 (73%)
Necrosis, Coagulative 1 (1%) 1 (1%)
Nephropathy, Chronic 76 (77%) 27 (84%) 56 (93%) 53 (88%) 78 (78%)
Artery, Necrosis, Fibrinoid 1 (1%)
Pelvis, Bacterium 1 (1%)
Renal Tubule, Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (98) (32) (60) (59) (100)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Inflammation, Chronic Active 2 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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