TR 393 Mouse Pathology Tables
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7681-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|
| 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X |
Hematopoietic Cell Proliferation | 2 2 |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Necrotizing | 4 4 4 4 4 |
Mineralization | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Diverticulum | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 1 1 2 1 1 1 1 1 1 1 |
Incisor, Ameloblast, Atrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|
| 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Hypertrophy | 2 1 |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Pigmentation, Melanin | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + I + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 2 4 2 2 2 2 2 3 4 3 3 2 2 2 4 |
Cyst | X X X X X |
Mineralization | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 4 4 3 4 |
Hyperplasia, Cystic, Glandular | 3 2 2 2 3 3 2 2 3 4 2 1 3 3 2 3 2 2 2 2|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|
| 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Mast Cell | |
Femoral, Myelofibrosis | 1 1 1 2 1 1 |
Humerus, Myelofibrosis | 2 1 1 1 1 1|
Mandible, Myelofibrosis | |
Maxilla, Hyperplasia, Mast Cell | |
Maxilla, Myelofibrosis | 1 1 1 2 2 1 |
Thoracic, Vertebra, Myelofibrosis | 1 2 1 1 1 3 2 2 3 2 1 1 1 2 2 1|
Tibia, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Mineralization | |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 2 |
Intervertebral Disc, Degeneration | 3 2 3 2 |
Periosteum, Tibia, Proliferation, | |
Focal | |
Rib, Cartilage, Necrosis | |
Thoracic, Vertebra, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|
| 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | X |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Harderian Gland | I M M M + M + M M M + + + + M + M + + + + + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hypertrophy | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|
DAY ON TEST | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|
| 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Lymphoid Tissue, Hyperplasia | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X|
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 2 2 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 3 3 |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Hemorrhage | |
Inflammation, Necrotizing | 4 4 4 4 4 4 4 4|
Mineralization | 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 1 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Diverticulum | 2|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 1 1 3 1 1 |
Incisor, Ameloblast, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|
DAY ON TEST | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|
| 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Hypertrophy | |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 2 4 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Pigmentation, Melanin | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + I + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 2 3 3 2 2 3 3 2 4 2 3 |
Cyst | X X X X X X X |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 4 4 3 |
Hyperplasia, Cystic, Glandular | 2 2 2 3 3 3 2 4 2 2 2 2 2 4 3 2 2 3|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|
DAY ON TEST | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|
| 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Mast Cell | |
Femoral, Myelofibrosis | 1 1 1 2 1 1 |
Humerus, Myelofibrosis | 2 1 1 1 |
Mandible, Myelofibrosis | |
Maxilla, Hyperplasia, Mast Cell | |
Maxilla, Myelofibrosis | 1 1 1 |
Thoracic, Vertebra, Myelofibrosis | 1 2 2 1 1 2 2 2 2 2 |
Tibia, Myelofibrosis | 2 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | 2 4 |
Mineralization | |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 2 |
Intervertebral Disc, Degeneration | 3 2 2 3 |
Periosteum, Tibia, Proliferation, | |
Focal | |
Rib, Cartilage, Necrosis | 3 |
Thoracic, Vertebra, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|
DAY ON TEST | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|
| 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | X X |
Hydrocephalus | 3 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + + M + M M M + + + + + + + + + M + + + M + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hypertrophy | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|
| 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | 3 |
Necrosis, Coagulative | 4 3 2 |
Vacuolization Cytoplasmic | 3 2 1 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Necrotizing | 4 4 4 4 |
Mineralization | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Diverticulum | |
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1|
Incisor, Ameloblast, Atrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|
| 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Hypertrophy | 1 2 |
Capsule, Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 2 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Pigmentation, Melanin | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 2 3 3 4 3 3 3 2 2 3 2 4 3 3 2|
Cyst | X X X X X X X |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 3 4 |
Hyperplasia, Cystic, Glandular | 2 2 4 2 3 3 3 3 2 2 4 2 2 2 3 3 2 3 2 4 3 3 4|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|
| 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Mast Cell | 2 |
Femoral, Myelofibrosis | 1 2 1 1 1 2 1 1 1 1 1 1 |
Humerus, Myelofibrosis | 1 3 1 1 2 1 2 |
Mandible, Myelofibrosis | |
Maxilla, Hyperplasia, Mast Cell | 1 |
Maxilla, Myelofibrosis | 2 2 1 1 1 1 |
Thoracic, Vertebra, Myelofibrosis | 2 2 4 2 2 2 1 2 1 2 1 3 3 1 2 1 1 1 2 |
Tibia, Myelofibrosis | 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 3 2 3 4 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Mineralization | |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | |
Intervertebral Disc, Degeneration | 3 1 1 1 3 2 |
Periosteum, Tibia, Proliferation, | |
Focal | |
Rib, Cartilage, Necrosis | |
Thoracic, Vertebra, Osteosclerosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|
| 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | |
Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + M + + M + M M + M + + + + + M + M M + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Hypertrophy | 4 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 2 1 1 1 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3| |
| 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 4.0|
Lymphoid Tissue, Hyperplasia | 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X | 23 |
Hematopoietic Cell Proliferation | | 6 2.0|
Inflammation, Chronic Active | | 2 2.5|
Necrosis, Coagulative | 2 2 | 7 2.7|
Vacuolization Cytoplasmic | 2 2 2 | 6 2.0|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 28 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Necrotizing | 4 4 4 4 4 4 4 | 24 4.0|
Mineralization | 2 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acanthosis | 3 | 5 2.6|
Diverticulum | | 1 2.0|
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Erosion | | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +| 90 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3| |
| 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1 1| 34 1.1|
Incisor, Ameloblast, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Cardiomyopathy, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Accessory Adrenal Cortical Nodule | | 3 |
Degeneration, Fatty | 1 2 | 2 1.5|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 | 3 2.0|
Hypertrophy | 2 2 | 6 1.7|
Capsule, Spindle Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 96 |
Hyperplasia | | 1 2.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + M + + + + M + + + +| 92 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Pars Distalis, Cyst | | 5 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 | 16 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 2.0|
Ultimobranchial Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 2 3 1 2 2 2 2 2 2| 30 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
Pigmentation, Melanin | | 1 2.0|
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3| |
| 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Atrophy | 2 2 2 2 3 2 2 1 2 2 2 2 3 2| 63 2.6|
Cyst | X X X X X | 24 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Angiectasis | 2 | 1 2.0|
Dilatation | 4 4 4 3| 13 3.7|
Hyperplasia, Cystic, Glandular | 2 4 2 2 3 2 3 1 2 4 1 4 4 4 3 3 2 3 4 3| 81 2.6|
Inflammation, Necrotizing | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Femoral, Hyperplasia, Mast Cell | | 1 2.0|
Femoral, Myelofibrosis | 1 1 1 2 1 1 1 1 1 1 | 34 1.1|
Humerus, Myelofibrosis | 1 1 1 1 1 1 2 1 1 2 1 | 28 1.3|
Mandible, Myelofibrosis | 3 | 1 3.0|
Maxilla, Hyperplasia, Mast Cell | | 1 1.0|
Maxilla, Myelofibrosis | 2 1 4 1 | 19 1.4|
Thoracic, Vertebra, Myelofibrosis | 1 3 2 3 1 1 2 2 1 2 2 2 2 2 2 1| 61 1.8|
Tibia, Myelofibrosis | 1 1 4 1 | 14 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 96 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hyperplasia, Plasma Cell | | 1 3.0|
Sinus, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hematopoietic Cell Proliferation | 4 3 3 2 2 4 | 20 2.9|
Hyperplasia, Lymphoid | 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 96 |
Cyst | X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hyperplasia, Cystic | 1 1 1 1| 8 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acanthosis | | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3| |
| 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
Hair Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + +| 90 |
Humerus, Osteosclerosis | | 2 2.0|
Intervertebral Disc, Degeneration | | 14 2.2|
Periosteum, Tibia, Proliferation, | | |
Focal | 3 | 1 3.0|
Rib, Cartilage, Necrosis | | 1 3.0|
Thoracic, Vertebra, Osteosclerosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Compression | | 3 |
Hydrocephalus | | 3 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | I | |
__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + I + + + M + M + M M + + M + + + + + M| 66 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hydronephrosis | | 1 3.0|
Hypertrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3| |
| 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 63 1.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 52 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|
DAY ON TEST | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|
| 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Leukocytosis | |
Necrosis, Coagulative | 2 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | |
Incisor, Lower, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|
DAY ON TEST | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|
| 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Follicular Cell, Hyperplasia | 3 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 3 4 3 4 4 |
Cyst | X X X X X X X |
Inflammation, Chronic Active | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 4 3 4 4 |
Hyperplasia, Cystic, Glandular | 2 2 3 3 4 2 2 2 3 2 2 4 3 3 2 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 1 1 1 |
Humerus, Myelofibrosis | 1 1 1 |
Maxilla, Myelofibrosis | 2 1 |
Thoracic, Vertebra, Myelofibrosis | 2 2 2 1 2 1 1 1 1 |
Tibia, Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|
DAY ON TEST | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|
| 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectopic Parathyroid Gland | X |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 1 1 1 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 1 1 |
Mandible, Inflammation, Suppurative | |
Tibia, Osteosclerosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + M + + + M + + + + + + + + + I + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | 1 1 2 1 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Nephropathy, Chronic | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4| |
DAY ON TEST | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7| |
| 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| 42 |
Lymphoid Tissue, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + +| 42 |
Basophilic Focus | X X | 6 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X | 4 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Leukocytosis | X X | 2 |
Necrosis, Coagulative | 1 4 1 | 4 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 3 2 2 | 5 2.2|
Bile Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Necrotizing | 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| 42 |
Diverticulum | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| 42 |
Erosion | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + +| 42 |
Dentine, Incisor, Dysplasia | 1 | 1 1.0|
Incisor, Lower, Dysplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4| |
DAY ON TEST | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7| |
| 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +| 42 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + M + + +| 37 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 41 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic Active | | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | |
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + + + + + + + + + + + +| 41 |
Atrophy | 2 4 3 3 3 4 | 14 3.3|
Cyst | X X X X X | 12 |
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + +| 42 |
Dilatation | 4 4 4 4 4| 11 3.9|
Hyperplasia, Cystic, Glandular | 1 4 4 2 3 3 3 2 3 3 4 3 3 2 1 3 2 | 34 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| 42 |
Femoral, Myelofibrosis | 1 1 | 5 1.0|
Humerus, Myelofibrosis | 1 3 2 1 | 7 1.4|
Maxilla, Myelofibrosis | 2 | 3 1.7|
Thoracic, Vertebra, Myelofibrosis | 1 1 1 2 2 1 3 2 1 2 2 | 20 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4| |
DAY ON TEST | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7| |
| 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Tibia, Myelofibrosis | 2 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +| 42 |
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + +| 40 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + +| 42 |
Hematopoietic Cell Proliferation | 4 2 2 4 4 2 | 10 2.9|
Hyperplasia, Lymphoid | 3 2 2| 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + +| 42 |
Cyst | X | 3 |
Ectopic Parathyroid Gland | | 1 |
Thymocyte, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| 41 |
Hyperplasia, Cystic | 1 1 1| 7 1.1|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + +| 42 |
Intervertebral Disc, Degeneration | | 2 1.0|
Mandible, Inflammation, Suppurative | 3 | 1 3.0|
Tibia, Osteosclerosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic Active | | 1 2.0|
Leukocytosis | X X | 2 |
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4| |
DAY ON TEST | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7| |
| 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + M + + M M + + + + +| 36 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + +| 42 |
Cyst | | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.0|
Necrosis, Coagulative | 3 | 1 3.0|
Nephropathy, Chronic | 2 1 1 1 2 1 | 12 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|
| 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Coagulative | 4 3 4 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Necrotizing | 4 4 4 4 4 4 |
Mineralization | 2 1 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Diverticulum | 2 |
Inflammation, Chronic Active | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|
| 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 |
Fibrosis | |
Hyperplasia | |
Hypertrophy | 2 |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 2 1 2 2 3 1 2 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 3 1 2 2 2 3 2 3 2 3 2 4|
Cyst | X X X X X X X X X X X|
Mineralization | |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4|
Hyperplasia, Cystic, Glandular | 4 4 4 2 2 3 2 2 4 4 4 1 2 3 3 4 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 1 1 2 2 1 2 2 1 1 1 1 1 1 2 2 |
Humerus, Myelofibrosis | 1 1 1 1 2 1 2 1 1 |
Maxilla, Myelofibrosis | 1 1 2 2 2 2 2 1 1 2 1 1 |
Thoracic, Vertebra, Myelofibrosis | 1 1 1 2 1 1 3 2 1 3 2 2 1 3 3 1 3 1 2 2 1|
Tibia, Myelofibrosis | 2 2 1 1 2 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + M + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|
| 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 2 2 4|
Hyperplasia, Lymphoid | 3 4 3 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Periosteum, Proliferation, | |
Focal | |
Intervertebral Disc, Degeneration | 2 1 2 1 2|
Periosteum, Maxilla, Proliferation, | |
Focal | 2|
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | |
Neuron, Necrosis | |
White Matter, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|
| 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + M M + + + + + + + + M + + M + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 2 2 2 1 1 1 1 1 1 1 1 3 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|
| 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Necrotizing | 4 4 4 4 |
Mineralization | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 2 |
Diverticulum | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + |
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|
| 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 |
Fibrosis | 2 |
Hyperplasia | 2 |
Hypertrophy | |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + |
Pars Distalis, Hyperplasia | 3 2 3 3 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Ultimobranchial Cyst | X |
Follicular Cell, Hyperplasia | 3 2 2 2 2 1 2 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | I + + + I + + + + + + + + + + + + + + + + |
Atrophy | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 |
Cyst | X X X X X X X X X X X |
Mineralization | 3 |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 4 4 4 4 4 |
Hyperplasia, Cystic, Glandular | 3 4 2 4 2 2 4 4 4 2 2 2 2 3 4 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Femoral, Myelofibrosis | 2 2 2 1 1 1 1 1 1 1 2 |
Humerus, Myelofibrosis | 2 2 2 2 1 2 2 1 1 1 1 |
Maxilla, Myelofibrosis | 3 1 2 1 2 2 |
Thoracic, Vertebra, Myelofibrosis | 1 2 3 2 2 1 2 1 2 2 2 2 1 3 1 2 2 3 3 |
Tibia, Myelofibrosis | 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|
| 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 3 3 3 |
Hyperplasia, Lymphoid | 3 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Humerus, Periosteum, Proliferation, | |
Focal | 2 |
Intervertebral Disc, Degeneration | 2 2 2 2 2 |
Periosteum, Maxilla, Proliferation, | |
Focal | |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | |
Hydrocephalus | |
Neuron, Necrosis | |
White Matter, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Degeneration | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 |
Mineralization | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|
| 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | M M M + M + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7| | |
DAY ON TEST | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2| | |
| 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + | 59 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X X X X | 22 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Necrosis, Coagulative | 1 | 4 3.0|
Vacuolization Cytoplasmic | 4 2 | 4 2.5|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | M + + + + + | 16 |
Inflammation, Necrotizing | 4 3 4 | 13 3.9|
Mineralization | 2 | 7 1.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | 3 3 | 6 2.5|
Diverticulum | | 1 2.0|
Inflammation, Chronic Active | 2 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + | 60 |
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 | 21 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7| | |
DAY ON TEST | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2| | |
| 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Fatty | | 3 2.3|
Fibrosis | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | | 1 2.0|
Capsule, Spindle Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + | 59 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 59 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 | 20 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
Ultimobranchial Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 1 2 1 1 | 27 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 2 |
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + M + + | 57 |
Atrophy | 1 2 2 4 3 3 2 2 | 38 2.2|
Cyst | X X X | 25 |
Mineralization | | 1 3.0|
Thrombosis | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 60 |
Dilatation | 4 3 3 4 4 3 4 | 14 3.8|
Hyperplasia, Cystic, Glandular | 2 4 2 3 2 3 4 3 3 2 4 3 3 3 3 | 54 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7| | |
DAY ON TEST | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2| | |
| 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 62 |
Femoral, Myelofibrosis | 1 1 1 2 2 1 2 | 34 1.4|
Humerus, Myelofibrosis | 1 1 2 1 1 2 2 | 27 1.4|
Maxilla, Myelofibrosis | 1 1 | 20 1.6|
Thoracic, Vertebra, Myelofibrosis | 3 2 1 3 1 2 2 2 2 2 | 50 1.9|
Tibia, Myelofibrosis | 1 | 16 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 57 |
Sinus, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 3 3 3 3 | 15 2.7|
Hyperplasia, Lymphoid | | 7 3.1|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + I + + + + + + + + | 56 |
Cyst | | 6 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + | 59 |
Hyperplasia, Cystic | 2 | 8 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 60 |
Humerus, Periosteum, Proliferation, | | |
Focal | | 1 2.0|
Intervertebral Disc, Degeneration | 2 2 2 | 13 1.8|
Periosteum, Maxilla, Proliferation, | | |
Focal | | 1 2.0|
Rib, Cartilage, Degeneration | 3 | 1 3.0|
Thoracic, Vertebra, Osteosclerosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 60 |
Compression | X X | 2 |
Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7| | |
DAY ON TEST | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2| | |
| 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Neuron, Necrosis | 2 | 1 2.0|
White Matter, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 4 2.0|
Mineralization | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 60 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Phthisis Bulbi | X | 1 |
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + M M + + M + + M + + + + + + + + | 48 |
Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 2 |
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 | 34 1.0|
Nephropathy, Chronic | 1 1 1 1 1 3 1 1 1 1 3 1 | 43 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|
DAY ON TEST | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|
| 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + A |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + A |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | 2 |
Mineralization | |
Necrosis, Coagulative | 2 3 |
Pigmentation, Hemosiderin | 2 |
Vacuolization Cytoplasmic | 2 3 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Necrotizing | 3 4 3 4 4 4 |
Mineralization | 3 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A |
Acinus, Atrophy | 3 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A |
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + |
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1 1 1 |
Dentine, Incisor, Necrosis | |
Incisor, Ameloblast, Atrophy | |
Incisor, Ameloblast, Degeneration | |
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|
DAY ON TEST | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|
| 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hypertrophy | |
Capsule, Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Craniopharyngeal Duct, Pars Distalis,| |
Inflammation, Suppurative | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 2 3 2 2 3 2 2 2 3 2 2 3 2 |
Cyst | X X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 4 3 |
Hyperplasia, Cystic, Glandular | 2 2 2 2 2 2 2 3 4 3 2 4 4 2 4 3 1 3 4 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|
DAY ON TEST | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|
| 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Humerus, Myelofibrosis | 3 1 2 1 1 3 2 1 2 |
Maxilla, Myelofibrosis | 1 2 1 1 1 3 1 |
Thoracic, Vertebra, Myelofibrosis | 1 1 2 2 1 1 2 2 2 2 3 2 2 2 2 2 1 2 |
Tibia, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + M + + + + + + + + + + + + + |
Sinus, Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + |
Depletion Lymphoid | 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 4 3 2 2 2 4 |
Hyperplasia, Lymphoid | 4 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | X X |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 1 1 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Alopecia | |
Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Intervertebral Disc, Degeneration | 3 |
Rib, Cartilage, Degeneration | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Compression | |
Hydrocephalus | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Degeneration | |
Spinal, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|
DAY ON TEST | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|
| 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Leukocytosis | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + M + + + M + + + + + + + M + + + + M M + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Hydronephrosis | |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|
DAY ON TEST | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|
| 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis, Coagulative | 4 4 2 3 2 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 4 2 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Necrotizing | 3 4 4 4 |
Mineralization | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 2 1 1 1 1 1 1 1 1|
Dentine, Incisor, Necrosis | 2 |
Incisor, Ameloblast, Atrophy | |
Incisor, Ameloblast, Degeneration | 2 |
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|
DAY ON TEST | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|
| 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy | 2 |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | X |
Craniopharyngeal Duct, Pars Distalis,| |
Inflammation, Suppurative | 4 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ultimobranchial Cyst | X |
Follicular Cell, Hyperplasia | 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + I + +|
Atrophy | 2 3 2 3 3 3 2 3 2 2 2 4 2|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 4|
Hyperplasia, Cystic, Glandular | 3 1 2 3 2 4 2 2 3 2 3 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|
DAY ON TEST | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|
| 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 1 1 1 1 1 1 1 1 1 1 1 |
Humerus, Myelofibrosis | 2 2 2 1 1 3 1 2 2 2|
Maxilla, Myelofibrosis | 1 1 2 1 1 2 1 2 2|
Thoracic, Vertebra, Myelofibrosis | 3 3 1 3 2 3 3 2 1 2 1 3 1 1 2|
Tibia, Myelofibrosis | 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + +|
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + + + + M +|
Cyst | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Chronic Active | 3 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 2 2 3 1 2 |
Rib, Cartilage, Degeneration | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 3 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Degeneration | |
Spinal, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|
DAY ON TEST | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|
| 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Leukocytosis | X |
Mineralization | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + I |
Middle Ear, Inflammation, Suppurative| 4 |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + + M + + M + + M + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 1 2 3 1 1 1 3 1 1|
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3| | |
| 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + | 58 |
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X | 3 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X X X | 11 |
Hematopoietic Cell Proliferation | 1 | 3 2.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 3 | 1 3.0|
Necrosis, Coagulative | 4 4 | 9 3.1|
Pigmentation, Hemosiderin | | 1 2.0|
Vacuolization Cytoplasmic | 2 3 | 7 2.6|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 18 |
Inflammation, Necrotizing | 4 4 4 4 | 14 3.8|
Mineralization | 2 2 3 2 | 5 2.4|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 59 |
Acinus, Atrophy | 2 2 | 4 2.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 59 |
Acanthosis | 2 3 3 | 5 2.6|
Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + | 60 |
Dentine, Incisor, Dysplasia | 1 2 1 1 1 | 23 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3| | |
| 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dentine, Incisor, Necrosis | 2 | 2 2.0|
Incisor, Ameloblast, Atrophy | 4 | 1 4.0|
Incisor, Ameloblast, Degeneration | | 1 2.0|
Peridontal Tissue, Incisor, | | |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | | 1 2.0|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 60 |
Cyst | X | 1 |
Degeneration, Fatty | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy | 2 2 2 | 4 2.0|
Capsule, Spindle Cell, Hyperplasia | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 61 |
Craniopharyngeal Duct, Pars Distalis,| | |
Cyst | | 1 |
Craniopharyngeal Duct, Pars Distalis,| | |
Inflammation, Suppurative | | 1 4.0|
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia | 2 2 2 | 16 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 1.5|
Ultimobranchial Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 2 2 2 2 1 2 4 | 24 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3| | |
| 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + I + + + + + + | 58 |
Atrophy | 2 4 2 4 4 3 2 2 2 2 2 2 | 39 2.5|
Cyst | X X X | 16 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 60 |
Dilatation | 4 | 6 3.8|
Hyperplasia, Cystic, Glandular | 1 4 2 2 3 2 3 2 3 4 3 2 3 2 3 2 3 | 56 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 61 |
Femoral, Myelofibrosis | 2 1 1 1 1 2 1 2 | 34 1.1|
Humerus, Myelofibrosis | 2 1 2 2 2 2 1 | 26 1.8|
Maxilla, Myelofibrosis | 2 1 2 2 2 | 21 1.5|
Thoracic, Vertebra, Myelofibrosis | 1 3 1 1 3 1 2 1 1 3 2 3 2 2 1 2 | 49 1.9|
Tibia, Myelofibrosis | 1 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 60 |
Renal, Sinus, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 57 |
Sinus, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 59 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 | 15 2.5|
Hyperplasia, Lymphoid | 3 3 3 2 | 7 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + + + + | 55 |
Cyst | X X | 4 |
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 1 | 8 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 60 |
Alopecia | X | 1 |
Inflammation, Chronic Active | | 1 3.0|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3| | |
| 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Intervertebral Disc, Degeneration | 2 2 | 8 2.1|
Rib, Cartilage, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 60 |
Compression | X | 2 |
Hydrocephalus | | 1 3.0|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
Sciatic, Degeneration | 3 | 1 3.0|
Spinal, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
White Matter, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
Leukocytosis | | 1 |
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Middle Ear, Inflammation, Suppurative| | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 3 |
Cornea, Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | + + M + + + M M + + + + + + M I + + | 45 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 60 |
Hydronephrosis | | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 | 26 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3| | |
| 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 1 2 2 1 1 1 1 1 2 | 29 1.3|
Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|
| 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 3 |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 4 4 4 4 4 |
Mineralization | 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Acinus, Hyperplasia | |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 1 1 1 1 1 |
Dentine, Incisor, Necrosis | |
Incisor, Ameloblast, Atrophy | |
Peridontal Tissue, Incisor, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|
| 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Cytoplasmic Alteration | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + + + + + + + + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | X |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
__________________________________________________________________________|
Ovary | + + + I + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 4 2 2 2 1 2 2 2 3 2 2 2 2|
Cyst | X X X X X X |
Necrosis, Coagulative | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Dilatation | 4 4 4 3 |
Hyperplasia, Cystic, Glandular | 2 2 2 2 2 4 3 4 2 2 3 1 2 4 2 3 2 3|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 1 1 1 1 1 1 1 2 1 2 2 1 1|
Humerus, Myelofibrosis | 1 1 2 2 2 1 1 1 2 2 2|
Mandible, Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|
| 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Maxilla, Myelofibrosis | 1 1 1 1 1 2 1 2 2 2|
Thoracic, Vertebra, Myelofibrosis | 1 3 2 2 3 3 3 2 4 3 2 2 1 1 3 3 3 3|
Tibia, Myelofibrosis | 2 1 2 1 1 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosclerosis | |
Humerus, Osteosclerosis | 1 |
Intervertebral Disc, Degeneration | 1 1 |
Rib, Cartilage, Degeneration | 3 |
Thoracic, Vertebra, Osteosclerosis | 3 |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|
| 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | I |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | M + M + + + + M + + + M I + M M M + + M M M + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Cyst | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 2 1 2 1 |
Perivascular, Hyperplasia, Lymphoid | |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X X|
Hematopoietic Cell Proliferation | 2 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 4 4 4 4 4 |
Mineralization | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
Acinus, Hyperplasia | 2 1 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 1 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 2 1 2 1 1 2 1 1 1 |
Dentine, Incisor, Necrosis | 3 |
Incisor, Ameloblast, Atrophy | 3 4 |
Peridontal Tissue, Incisor, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Cytoplasmic Alteration | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 3 3 3 2 2 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | X X |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 3 1 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 2 3 2 2 3 3 2 2 2 2 3 2 1 2 4 2|
Cyst | X X X X X X X X X X |
Necrosis, Coagulative | 4 |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 4 3 4 4 |
Hyperplasia, Cystic, Glandular | 2 2 3 3 3 3 3 3 4 2 2 3 2 3 2 4 3 2 3 2 4 3|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2|
Humerus, Myelofibrosis | 2 3 2 2 2 2 2 1 2 2 1 2 3|
Mandible, Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Maxilla, Myelofibrosis | 2 2 1 1 2 2 1 2 2 3 1 1 2 1 1|
Thoracic, Vertebra, Myelofibrosis | 2 2 2 2 3 2 3 2 4 2 2 3 2 2 3 2 3 3 3 2 4|
Tibia, Myelofibrosis | 2 2 2 1 1 1 1 1 1 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 2 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M M M + + + + + + + + + + + + + + + + + + + + M|
Cyst | |
Hyperplasia, Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosclerosis | 3 |
Humerus, Osteosclerosis | 4 |
Intervertebral Disc, Degeneration | 3 2 3 3 2 2 |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | 4 |
Tibia, Osteosclerosis | 4 1 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | M M M + + + M M + M M M M M M M M M M + + M M M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Cyst | X |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 2 1 1|
Nephropathy, Chronic | 3 1 1 1 1|
Perivascular, Hyperplasia, Lymphoid | 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|
DAY ON TEST | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|
| 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | 2 |
Inflammation, Necrotizing | 4 4 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + |
Dentine, Incisor, Dysplasia | 3 1 1 1 1 |
Dentine, Incisor, Necrosis | 3 |
Incisor, Ameloblast, Atrophy | 3 |
Peridontal Tissue, Incisor, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|
DAY ON TEST | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|
| 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Cytoplasmic Alteration | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + M + + + + M + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 1 2 2 3 1 2 1 3 1 2 2 |
Cyst | X X X X |
Necrosis, Coagulative | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 4 3 |
Hyperplasia, Cystic, Glandular | 4 2 2 2 2 2 2 1 2 2 3 3 4 2 2 2 2 2 2 3 3 2 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 1 1 1 1 2 2 2 1 1 2 1 1 |
Humerus, Myelofibrosis | 1 2 1 2 1 1 2 2 3 1 1|
Mandible, Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|
DAY ON TEST | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|
| 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Maxilla, Myelofibrosis | 2 2 1 1 1 1 2 1 1 2 |
Thoracic, Vertebra, Myelofibrosis | 2 2 2 3 2 2 2 2 3 2 2 1 3 4 2 2 1 1 2 1 |
Tibia, Myelofibrosis | 1 1 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 3 3 4 3 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + M + + + + +|
Cyst | X X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Femur, Osteosclerosis | |
Humerus, Osteosclerosis | |
Intervertebral Disc, Degeneration | 3 2 3 2 2 2 |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|
DAY ON TEST | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|
| 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | M + + + + M M + + M M M + + + + M M M M M + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Cyst | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 |
Nephropathy, Chronic | 1 1 1 2 1 2 1 2 1 1 1 |
Perivascular, Hyperplasia, Lymphoid | |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1| | |
DAY ON TEST | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6| | |
| 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 97 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Inflammation, Chronic Active | 2 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 97 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 97 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X X | 12 |
Hematopoietic Cell Proliferation | 2 | 6 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic Active | 3 | 3 2.7|
Necrosis, Coagulative | 3 | 3 3.3|
Vacuolization Cytoplasmic | | 6 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 28 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Necrotizing | 4 4 | 15 4.0|
Mineralization | 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Acinus, Atrophy | | 2 3.5|
Acinus, Hyperplasia | | 2 1.5|
Duct, Ectasia | 2 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Acanthosis | 2 | 3 2.0|
Inflammation, Chronic Active | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Erosion | | 3 2.3|
Mineralization | | 4 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + | 89 |
Dentine, Incisor, Dysplasia | 1 1 1 | 24 1.2|
Dentine, Incisor, Necrosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1| | |
DAY ON TEST | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6| | |
| 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Ameloblast, Atrophy | | 3 3.3|
Peridontal Tissue, Incisor, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | | 1 |
Cytoplasmic Alteration | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 1 | 2 1.5|
Capsule, Spindle Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 92 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 97 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 | 25 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | 2 | 2 2.0|
Ultimobranchial Cyst | | 3 |
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 2 2 2 2 1 1 | 33 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Atrophy | 2 2 2 2 3 4 2 2 1 2 3 | 59 2.2|
Cyst | X X X X X | 25 |
Necrosis, Coagulative | | 1 4.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1| | |
DAY ON TEST | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6| | |
| 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Dilatation | 4 4 3 3 | 14 3.6|
Hyperplasia, Cystic, Glandular | 2 2 2 2 3 3 1 2 3 2 1 3 3 3 3 2 2 2 | 81 2.5|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Femoral, Myelofibrosis | 1 1 1 1 1 1 1 1 1 1 1 | 53 1.2|
Humerus, Myelofibrosis | 1 2 2 1 1 1 4 2 1 2 2 1 | 47 1.7|
Mandible, Myelofibrosis | 4 | 1 4.0|
Maxilla, Myelofibrosis | 3 2 1 4 2 1 1 2 1 | 44 1.6|
Thoracic, Vertebra, Myelofibrosis | 2 2 1 3 3 3 2 2 3 2 2 2 3 2 2 | 74 2.3|
Tibia, Myelofibrosis | 2 3 | 26 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 94 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Hematopoietic Cell Proliferation | 3 3 3 3 | 20 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 2 2 | 11 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + | 92 |
Cyst | | 6 |
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Hyperplasia, Cystic | 1 | 7 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 89 |
Femur, Osteosclerosis | | 1 3.0|
Humerus, Osteosclerosis | | 2 2.5|
Intervertebral Disc, Degeneration | 2 2 | 16 2.2|
Rib, Cartilage, Degeneration | | 1 3.0|
Thoracic, Vertebra, Osteosclerosis | 3 | 3 3.3|
Tibia, Osteosclerosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1| | |
DAY ON TEST | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6| | |
| 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
175 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Compression | X | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
White Matter, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + M + M + + + + + M + + + + M + | 52 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Atypia Cellular | | 1 |
Cyst | | 1 |
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 | 28 1.0|
Nephropathy, Chronic | 2 1 3 1 1 | 26 1.4|
Perivascular, Hyperplasia, Lymphoid | 2 | 2 2.0|
Renal Tubule, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 97 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|
DAY ON TEST | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|
| 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X |
Cytologic Alterations | |
Eosinophilic Focus | X X X |
Hyperplasia | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 2 2 1 3 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Necrotizing | 4 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 |
Acinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 2 2 4 3 3 3 2 3 4 3 4 3 4 2 3 3 1 2|
Dentine, Incisor, Necrosis | 3 2 |
Incisor, Lower, Dysplasia | |
Incisor, Ameloblast, Atrophy | 4 4 3 3 4 3 4 3 4 3 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|
DAY ON TEST | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|
| 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic Active | |
Mesenteric Artery, Necrosis, | |
Fibrinoid | |
Renal Artery, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | |
Hyperplasia | |
Hypertrophy | 2 1 2 1 1|
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + M + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + I M + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Granuloma Sperm | 4 |
Inflammation, Chronic Active | |
Duct, Dilatation | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 3 4 4 3 3 3 2 3 3 3 4 3|
Inflammation, Chronic Active | 3 2 2 2 3 4 2 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|
DAY ON TEST | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|
| 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 4 3 3 4 4 4 3 4 3 2 4 4 3 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Maxilla, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + M M M M + + + + + + + M + + + + + + + +|
Cyst | X X|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 3 2 |
Thoracic, Vertebra, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Leukocytosis | X |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|
DAY ON TEST | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|
| 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Hyperplasia, | |
Squamous | 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | +|
Phthisis Bulbi | X|
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + M + + M M + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Inflammation, Chronic Active | 2 |
Mineralization | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | 4 |
Nephropathy, Chronic | 2 2 1 1 1 2 1 1 2 2 2 2 2 2 2 1 2 1 1|
Artery, Necrosis, Fibrinoid | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|
| 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X |
Cytologic Alterations | |
Eosinophilic Focus | X X |
Hyperplasia | 2 |
Inflammation, Chronic Active | |
Necrosis, Coagulative | 4|
Vacuolization Cytoplasmic | 2 2 2 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Necrotizing | 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 3 |
Acinus, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 3|
Mineralization | 1 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 4 3 1 4 3 1 4 2 2 1 4 3 3 1 1 2 4 3 1 3 3 4|
Dentine, Incisor, Necrosis | |
Incisor, Lower, Dysplasia | 3 4 4 3 3 |
Incisor, Ameloblast, Atrophy | 4 4 3 4 4 4 3 4 4 3 3 3 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|
| 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic Active | 3 |
Mesenteric Artery, Necrosis, | |
Fibrinoid | 3 |
Renal Artery, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Hyperplasia | |
Hypertrophy | 1 1 2 2 2 2 2 1 1 2 2 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 2 4 4 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + M + + + + + + + + M + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + I M +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Granuloma Sperm | 3 |
Inflammation, Chronic Active | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Atrophy | 3 3 3 3 4 3 2 3 4 4 3 4 4 2 3 2 3 |
Inflammation, Chronic Active | 2 2 4 2 4 4 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|
| 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 4 4 2 3 3 3 4 4 3 3 3 4 3 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Maxilla, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | X X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M + M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 3 |
Thoracic, Vertebra, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Leukocytosis | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|
| 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Hyperplasia, | |
Squamous | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + + M + M + + + + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 2 1 1 2 2 1 2 2 2 2 2 2 1 2 1 2 2 2 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + I + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|
| 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X|
Clear Cell Focus | X X X X X X X X X X X X |
Cytologic Alterations | |
Eosinophilic Focus | X X X |
Hyperplasia | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Necrotizing | 3 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Acinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 4 1 2 2 4 2 2 3 2 2 3 4 2 3 4 2 4 |
Dentine, Incisor, Necrosis | |
Incisor, Lower, Dysplasia | 3 |
Incisor, Ameloblast, Atrophy | 4 4 3 1 3 4 4 3 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|
| 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic Active | |
Mesenteric Artery, Necrosis, | |
Fibrinoid | |
Renal Artery, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | X |
Hyperplasia | 2 |
Hypertrophy | 2 2 2 1 2 1 2 2 2 2 1|
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | 3 |
Capsule, Spindle Cell, Hyperplasia | 3 3 3 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | |
Follicular Cell, Hyperplasia | 1 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | X |
Granuloma Sperm | |
Inflammation, Chronic Active | |
Duct, Dilatation | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + +|
Atrophy | 3 4 4 4 3 3 3 2 3 |
Inflammation, Chronic Active | 4 4 2 4 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|
| 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 4 3 4 3 3 4 4 3 4 3 4 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 1 |
Maxilla, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M + + + + M + + + + + + + M + + + + + + M|
Cyst | X X X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M + M + M + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 3 |
Thoracic, Vertebra, Osteosclerosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Leukocytosis | |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|
| 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
0 PPM | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Hyperplasia, | |
Squamous | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Phthisis Bulbi | |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Mineralization | 3 |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + M + + + M + + + + M + + + + + + + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Inflammation, Chronic Active | 4 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 3 1 2 2 2 2 1 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4| | |
DAY ON TEST | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5| | |
| 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | T |
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
0 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + | 96 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Basophilic Focus | X X X X | 9 |
Clear Cell Focus | X X X X X X X X X X | 36 |
Cytologic Alterations | X | 1 |
Eosinophilic Focus | X | 9 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | | 2 2.0|
Necrosis, Coagulative | 2 4 | 4 2.8|
Vacuolization Cytoplasmic | 2 2 2 2 2 3 2 3 | 24 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Inflammation, Necrotizing | 4 4 4 | 8 3.9|
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + | 98 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 2 | 3 2.0|
Acinus, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Acanthosis | 3 2 | 2 2.5|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Erosion | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + | 90 |
Dentine, Incisor, Dysplasia | 3 3 3 3 2 1 1 1 4 2 3 | 69 2.6|
Dentine, Incisor, Necrosis | | 2 2.5|
Incisor, Lower, Dysplasia | 4 2 | 8 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4| | |
DAY ON TEST | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5| | |
| 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | T |
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
0 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Ameloblast, Atrophy | 3 3 3 3 2 2 4 3 | 42 3.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Mesenteric Artery, Inflammation, | | |
Chronic Active | | 1 3.0|
Mesenteric Artery, Necrosis, | | |
Fibrinoid | | 1 3.0|
Renal Artery, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Cardiomyopathy, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Accessory Adrenal Cortical Nodule | | 2 |
Cyst | | 2 |
Hyperplasia | 2 1 | 3 1.7|
Hypertrophy | 2 1 2 2 2 1 2 | 34 1.6|
Bilateral, Capsule, Spindle Cell, | | |
Hyperplasia | | 1 3.0|
Capsule, Spindle Cell, Hyperplasia | 4 3 4 | 11 3.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 96 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + | 98 |
Hyperplasia | 2 3 | 13 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + M + + + + | 88 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + | 91 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Cyst | | 1 |
Inflammation, Chronic Active | | 1 1.0|
Follicular Cell, Hyperplasia | | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4| | |
DAY ON TEST | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5| | |
| 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | T |
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
0 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Aspermia | | 1 |
Granuloma Sperm | | 2 3.5|
Inflammation, Chronic Active | 3 3 | 2 3.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 57 |
Atrophy | 4 3 3 3 3 3 4 | 48 3.2|
Inflammation, Chronic Active | 4 3 2 3 | 22 2.9|
Duct, Dilatation | 3 4 3 2 3 4 4 2 | 51 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 98 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Femoral, Myelofibrosis | | 1 1.0|
Maxilla, Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 94 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Hematopoietic Cell Proliferation | 3 2 2 | 8 2.6|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + M + + + + + + + | 87 |
Cyst | X X X X | 11 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M + + M M + M M M + M M M M M M M M M M | 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4| | |
DAY ON TEST | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5| | |
| 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | T |
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
0 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + | 89 |
Intervertebral Disc, Degeneration | 3 2 | 6 2.7|
Thoracic, Vertebra, Osteosclerosis | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | 2 1 | 4 1.8|
Leukocytosis | | 1 |
Pigmentation, Hemosiderin | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 4 2.3|
Mediastinum, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Hyperplasia, | | |
Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Phthisis Bulbi | | 1 |
Cornea, Inflammation, Chronic Active | 4 | 2 3.5|
Cornea, Mineralization | | 1 3.0|
Lens, Cataract | 3 | 2 3.5|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | M + + + + + + + + + + + + + + + + + + + + + + + | 85 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 99 |
Cyst | X | 17 |
Inflammation, Chronic Active | | 2 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 75 1.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4| | |
DAY ON TEST | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5| | |
| 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | T |
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
0 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 2 1 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 | 76 1.8|
Artery, Necrosis, Fibrinoid | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 98 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|
DAY ON TEST | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|
| 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X|
Clear Cell Focus, Multiple | |
Eosinophilic Focus | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 2 2 2 3 3 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 4 1 3 3 3 4 3 3 4 3 3|
Incisor, Lower, Dysplasia | 2 3 3 4 |
Incisor, Ameloblast, Atrophy | 4 3 3 4 4 3 4 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 1 2 1 1 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|
DAY ON TEST | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|
| 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 3 3 4 4|
Inflammation, Chronic Active | 2 2 3 2|
Duct, Dilatation | 4 3 3 3 3 3 3 3 4 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M M M + M M M M M + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Intervertebral Disc, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|
DAY ON TEST | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|
| 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Thoracic, Vertebra, Osteosclerosis | |
Tibia, Fracture Healed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + + + M + + + M + + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hydronephrosis | 3 |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 3 1 2 2 2 1 1 1 1 2 1 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5| |
DAY ON TEST | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2| |
| 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + +| 32 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + +| 32 |
Basophilic Focus | | 1 |
Clear Cell Focus | X X X | 7 |
Clear Cell Focus, Multiple | X| 1 |
Eosinophilic Focus | X X | 2 |
Inflammation, Chronic Active | 4 | 2 3.0|
Necrosis, Coagulative | 2 2 1| 3 1.7|
Vacuolization Cytoplasmic | 2 2 3 2 3 2 | 13 2.2|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + +| 32 |
Diverticulum | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + +| 32 |
Dentine, Incisor, Dysplasia | 4 3 3 3 4 3| 17 3.2|
Incisor, Lower, Dysplasia | 3 2 | 6 2.8|
Incisor, Ameloblast, Atrophy | 3 3 3 3 4 3| 15 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + +| 32 |
Mineralization | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5| |
DAY ON TEST | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2| |
| 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +| 32 |
Hyperplasia | | 1 2.0|
Hypertrophy | 2 2 | 7 1.6|
Bilateral, Capsule, Spindle Cell, | | |
Hyperplasia | | 1 4.0|
Capsule, Spindle Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + +| 32 |
Hyperplasia | 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + +| 32 |
Ultimobranchial Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 12 |
Atrophy | 3 | 11 3.7|
Inflammation, Chronic Active | 4 | 5 2.6|
Duct, Dilatation | 2 | 11 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + +| 31 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + +| 31 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 32 |
Hematopoietic Cell Proliferation | 3 4 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5| |
DAY ON TEST | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2| |
| 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
SPECIAL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + + + + + +| 28 |
Cyst | X| 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + M M M M M| 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 32 |
Intervertebral Disc, Degeneration | 2 | 2 2.0|
Thoracic, Vertebra, Osteosclerosis | 1 | 1 1.0|
Tibia, Fracture Healed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 32 |
Leukocytosis | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + +| 32 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + M + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 32 |
Cyst | X | 4 |
Hydronephrosis | 4 | 2 3.5|
Inflammation, Chronic Active | 4 | 1 4.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Nephropathy, Chronic | 2 2 1 1 2 1 1 1 1 3 2 1| 27 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|
| 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | 3 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X X X X X |
Cytologic Alterations | X |
Eosinophilic Focus | X X|
Fibrosis | 2 |
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 2 1 2 |
Mineralization | 2 |
Necrosis, Coagulative | 3 4 |
Vacuolization Cytoplasmic | 3 2 2 3 2 2 2 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 3 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Inflammation, Chronic Active | |
Acinus, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Degeneration | |
Dentine, Incisor, Dysplasia | 2 2 4 1 3 3 3 3 4 3 3 1 4 3 2 1 3 4|
Gingiva, Incisor, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|
| 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Suppurative | |
Incisor, Lower, Dysplasia | 4 1 4 3 4 4|
Incisor, Ameloblast, Atrophy | 4 3 3 3 3 3 3 3 2 3 4|
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | |
Cyst | X |
Hyperplasia | |
Hypertrophy | 2 1 1 2 2 2 |
Capsule, Spindle Cell, Hyperplasia | 2 4 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Follicular Cell, Hyperplasia | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 4 2 2 3 3|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|
| 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 2 2 3 2 2 2 |
Duct, Dilatation | 4 3 2 3 2 2 2 2 3 2 4 3 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Humerus, Myelofibrosis | 1 |
Maxilla, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 3 2 3 |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | |
Intervertebral Disc, Degeneration | 1 2 3 2 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|
| 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2|
Alveolar Epithelium, Hyperplasia | 2 |
Bronchus, Dilatation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + M M + + + M + + M +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hydronephrosis | |
Inflammation, Chronic Active | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 3|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|
DAY ON TEST | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|
| 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X X|
Cytologic Alterations | |
Eosinophilic Focus | X X X X X |
Fibrosis | |
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 2 2 |
Mineralization | |
Necrosis, Coagulative | 3 2 |
Vacuolization Cytoplasmic | 3 2 2 1 2 2 2|
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 4 |
Mineralization | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Inflammation, Chronic Active | 2 |
Acinus, Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Degeneration | |
Dentine, Incisor, Dysplasia | 1 3 2 3 1 1 3 1 2 2 4 3 3 1 4 3 1 2|
Gingiva, Incisor, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|
DAY ON TEST | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|
| 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Suppurative | 2 |
Incisor, Lower, Dysplasia | 3 4 |
Incisor, Ameloblast, Atrophy | 3 3 4 4 3 3 4 3 |
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Atrophy | |
Cyst | |
Hyperplasia | |
Hypertrophy | 2 2 2 2 1 2 |
Capsule, Spindle Cell, Hyperplasia | 3 4 4 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + M + + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Atrophy | 2 2 4 3 2 1 3 4 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|
DAY ON TEST | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|
| 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 2 2 2 2 |
Duct, Dilatation | 2 3 3 2 2 3 3 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Humerus, Myelofibrosis | |
Maxilla, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Renal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + + + M + +|
Atrophy | |
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 2 |
Intervertebral Disc, Degeneration | 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|
DAY ON TEST | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|
| 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 3 2 2 |
Bronchus, Dilatation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + M + + + + + M M + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Hydronephrosis | 4 |
Inflammation, Chronic Active | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 2 2 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3| | |
| 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 60 |
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 60 |
Lymphoid Tissue, Hyperplasia | 3 | 2 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | X X | 6 |
Clear Cell Focus | X X X X X X X X | 27 |
Cytologic Alterations | | 1 |
Eosinophilic Focus | X X | 9 |
Fibrosis | | 1 2.0|
Hyperplasia | | 2 4.0|
Inflammation, Chronic Active | | 7 1.9|
Mineralization | | 1 2.0|
Necrosis, Coagulative | 2 | 5 2.8|
Vacuolization Cytoplasmic | 2 2 2 | 18 2.1|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Inflammation, Necrotizing | 4 4 | 4 3.8|
Mineralization | 1 | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 1.0|
Acinus, Inflammation, Chronic Active | | 1 2.0|
Acinus, Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3| | |
| 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + | 60 |
Dentine, Incisor, Degeneration | 3 | 1 3.0|
Dentine, Incisor, Dysplasia | 3 4 3 2 3 1 2 1 2 3 4 3 1 2 4 3 | 52 2.5|
Gingiva, Incisor, Inflammation, | | |
Suppurative | | 1 2.0|
Incisor, Lower, Dysplasia | 2 2 1 2 2 3 | 14 2.8|
Incisor, Ameloblast, Atrophy | 3 4 3 3 3 3 4 3 4 3 | 29 3.2|
Peridontal Tissue, Incisor, | | |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Atrophy | 3 | 1 3.0|
Cyst | X | 2 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 2 1 2 2 | 16 1.8|
Capsule, Spindle Cell, Hyperplasia | 3 | 8 3.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 3 2 | 7 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + + + + + + + + | 55 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 59 |
Pars Distalis, Cyst | X X X | 6 |
Pars Distalis, Hyperplasia | | 1 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 2 2 | 10 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3| | |
| 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + | 60 |
Granuloma Sperm | 2 | 2 3.0|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 40 |
Atrophy | 2 4 2 4 4 3 4 4 3 3 2 | 30 2.8|
Inflammation, Chronic Active | 2 2 1 2 2 2 | 18 2.1|
Duct, Dilatation | 2 3 3 3 2 2 3 2 4 3 2 3 | 36 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + | 60 |
Seminiferous Tubule, Degeneration | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 60 |
Femoral, Myelofibrosis | 1 | 1 1.0|
Humerus, Myelofibrosis | | 1 1.0|
Maxilla, Myelofibrosis | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 60 |
Renal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 4 2.5|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 3 4 2 | 10 2.6|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + M M M + + + + | 52 |
Atrophy | 2 2 | 2 2.0|
Cyst | X X X X | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M + M M M M M M M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3| | |
| 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 60 |
Humerus, Osteosclerosis | | 1 2.0|
Intervertebral Disc, Degeneration | 1 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
Bronchus, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 60 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 | 5 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + M + M + + + + + M + + + + + + + | 49 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 60 |
Cyst | X X | 10 |
Hydronephrosis | | 1 4.0|
Inflammation, Chronic Active | | 2 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0|
Nephropathy, Chronic | 2 2 1 2 1 2 2 3 2 2 2 1 2 1 2 1 2 2 | 56 1.9|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 60 |
Calculus Gross Observation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|
| 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Intussusception | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X X X X X X |
Eosinophilic Focus | X X X X |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis, Coagulative | 4 1 |
Vacuolization Cytoplasmic | 2 2 2 3 3 1 2 2 2 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 4 4 4 |
Mineralization | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Amyloid Deposition | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Diverticulum | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
Perivascular, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 3 3 3 3 1 3 4 4 1 4 1 1 1 4 1 1 1 4 4|
Incisor, Lower, Dysplasia | 2 4 3 4 3 2 2 2|
Incisor, Ameloblast, Atrophy | 3 3 3 3 4 4 4 4 3 4 4|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|
| 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pulp, Incisor, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic Active | 4 |
Mesenteric Artery, Inflammation, | |
Chronic Active | 4 |
Thoracic, Artery, Inflammation, | |
Chronic Active | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Hypertrophy | 1 2 2 2 2 1 2 2 2 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 2 3 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Ultimobranchial Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 1 2 |
__________________________________________________________________________|
Penis | + |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|
| 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Atrophy | 2 2 3 2 2 2 2 4 |
Inflammation, Chronic Active | 4 2 2 3 2 |
Duct, Dilatation | 4 4 4 2 4 4 2 4 2 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 |
Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Humerus, Myelofibrosis | |
Tibia, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + M + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + I M + + + + + + M + + M + + + M|
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteosclerosis, Focal | |
Intervertebral Disc, Degeneration | 3 1 |
Rib, Cartilage, Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|
| 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Middle Ear, Inflammation, Suppurative| 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + M M + M + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Necrotizing | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 2 2 2 1 1 1 2 1 2 1 1 2 1 2 2 2 1 2 2 |
Renal Tubule, Epithelium, Hyperplasia| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|
| 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Intussusception | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X X X X X X X X |
Eosinophilic Focus | X X X X |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 2 3 2 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 3 |
Inflammation, Necrotizing | 4 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Amyloid Deposition | 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 |
Cyst Epithelial Inclusion | |
Diverticulum | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Mineralization | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + |
Dentine, Incisor, Dysplasia | 1 1 4 4 1 1 3 4 3 2 4 1 1 1 3 4 1 |
Incisor, Lower, Dysplasia | 3 4 3 3 |
Incisor, Ameloblast, Atrophy | 2 4 4 4 4 3 4 3 4 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|
| 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pulp, Incisor, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
Mesenteric Artery, Inflammation, | |
Chronic Active | |
Thoracic, Artery, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Perivascular, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hyperplasia | 1 |
Hypertrophy | 2 2 2 2 1 2 1 2 2 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 2 2 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M + + |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Mineralization | |
__________________________________________________________________________|
Penis | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|
| 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + |
Atrophy | 4 2 2 4 4 3 3 2 3 3 3 3 3 |
Inflammation, Chronic Active | 3 2 3 3 4 2 |
Duct, Dilatation | 2 4 2 2 2 2 2 3 3 2 2 4 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Femoral, Myelofibrosis | 2 1 1 1 |
Humerus, Myelofibrosis | 1 |
Tibia, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Hematopoietic Cell Proliferation | 3 3 2 |
__________________________________________________________________________|
Thymus | + M + M + + + M M + M M + + + + + + M + |
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Calvarium, Osteosclerosis, Focal | |
Intervertebral Disc, Degeneration | 2 2 1 |
Rib, Cartilage, Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|
| 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Harderian Gland | + + M M + + + + + + + + + + M + + + + M |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | X X X X X |
Inflammation, Necrotizing | 4 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy, Chronic | 2 3 1 1 2 2 1 3 2 2 2 1 2 1 2 1 2 1 1 |
Renal Tubule, Epithelium, Hyperplasia| 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 7| 1| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 6| 0| | |
DAY ON TEST | 5| 6| 6| 5| 5| 3| 6| 3| 3| 6| 6| 2| 3| 2| 3| 2| 3| 3| 2| 1| | |
| 9| 5| 6| 9| 9| 6| 5| 6| 6| 6| 6| 9| 7| 9| 7| 9| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A | 59 |
Intussusception | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A | 59 |
Lymphoid Tissue, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 61 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X X X X X X | 31 |
Eosinophilic Focus | X X X X | 12 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative | 2 | 4 2.8|
Vacuolization Cytoplasmic | 2 3 2 2 2 | 17 2.2|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Necrotizing | 2 | 6 3.7|
Mineralization | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 60 |
Acinus, Amyloid Deposition | | 1 1.0|
Acinus, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | | 1 |
Diverticulum | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Mineralization | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 7| 1| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 6| 0| | |
DAY ON TEST | 5| 6| 6| 5| 5| 3| 6| 3| 3| 6| 6| 2| 3| 2| 3| 2| 3| 3| 2| 1| | |
| 9| 5| 6| 9| 9| 6| 5| 6| 6| 6| 6| 9| 7| 9| 7| 9| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + | 60 |
Dentine, Incisor, Dysplasia | 3 2 3 3 3 4 4 2 2 1 3 3 | 48 2.5|
Incisor, Lower, Dysplasia | 3 3 4 3 3 | 17 3.0|
Incisor, Ameloblast, Atrophy | 3 4 3 4 4 3 3 | 27 3.5|
Pulp, Incisor, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation, Chronic Active | | 1 4.0|
Mesenteric Artery, Inflammation, | | |
Chronic Active | | 1 4.0|
Thoracic, Artery, Inflammation, | | |
Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 59 |
Perivascular, Inflammation, Chronic | | |
Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hyperplasia | 2 1 | 4 1.5|
Hypertrophy | 2 2 2 2 2 | 23 1.8|
Bilateral, Capsule, Spindle Cell, | | |
Hyperplasia | 3 | 1 3.0|
Capsule, Spindle Cell, Hyperplasia | 2 3 | 10 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 2 2 | 17 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M | 57 |
Pars Distalis, Cyst | | 5 |
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 4.0|
Ultimobranchial Cyst | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 7| 1| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 6| 0| | |
DAY ON TEST | 5| 6| 6| 5| 5| 3| 6| 3| 3| 6| 6| 2| 3| 2| 3| 2| 3| 3| 2| 1| | |
| 9| 5| 6| 9| 9| 6| 5| 6| 6| 6| 6| 9| 7| 9| 7| 9| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 33 |
Atrophy | 2 3 3 3 2 4 | 27 2.8|
Inflammation, Chronic Active | 4 4 3 | 14 2.9|
Duct, Dilatation | 3 2 3 3 2 3 | 32 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 60 |
Mineralization | | 2 2.5|
Necrosis, Coagulative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 60 |
Femoral, Myelofibrosis | 2 | 5 1.4|
Humerus, Myelofibrosis | 1 | 2 1.0|
Tibia, Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M | 56 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 | 7 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + M + + | 45 |
Cyst | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 7| 1| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 6| 0| | |
DAY ON TEST | 5| 6| 6| 5| 5| 3| 6| 3| 3| 6| 6| 2| 3| 2| 3| 2| 3| 3| 2| 1| | |
| 9| 5| 6| 9| 9| 6| 5| 6| 6| 6| 6| 9| 7| 9| 7| 9| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M M M M M M M M M M M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 60 |
Calvarium, Osteosclerosis, Focal | 3 | 1 3.0|
Intervertebral Disc, Degeneration | 2 | 6 1.8|
Rib, Cartilage, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 60 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Middle Ear, Inflammation, Suppurative| | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + M + + + + + + + + | 52 |
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 60 |
Cyst | X X X X X | 13 |
Inflammation, Necrotizing | | 1 4.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
Nephropathy, Chronic | 2 1 1 1 2 1 1 1 1 2 1 2 1 1 | 53 1.5|
Renal Tubule, Epithelium, Hyperplasia| | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A | 59 |
Calculus Micro Observation Only | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 7| 3| 7| 4| 6| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 3| 8| 3| 5| 2| 6| 3| 8| 3| 5| 3| 3| 3| 1| 6| 2| 2| 3| 3| 3| 3|
| 8| 5| 0| 0| 0| 6| 0| 9| 3| 6| 0| 4| 1| 9| 1| 1| 1| 9| 5| 9| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X X X |
Eosinophilic Focus | |
Mineralization | |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 2 2 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 4 |
Inflammation, Necrotizing | 4 |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Diverticulum | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Concretion | |
Dentine, Incisor, Dysplasia | 2 2 3 3 1 1 4 1 3 4 1 3 1 2 3 1 3 3 3|
Dentine, Incisor, Necrosis | |
Incisor, Lower, Dysplasia | 3 2 |
Incisor, Ameloblast, Atrophy | 3 3 3 4 3 3 4 3 3 3 3 3 3|
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 7| 3| 7| 4| 6| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 3| 8| 3| 5| 2| 6| 3| 8| 3| 5| 3| 3| 3| 1| 6| 2| 2| 3| 3| 3| 3|
| 8| 5| 0| 0| 0| 6| 0| 9| 3| 6| 0| 4| 1| 9| 1| 1| 1| 9| 5| 9| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Hypertrophy | 1 2 2 2 2 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 4 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + M + + + + M + + + + M +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | X |
Atrophy | 4 2 |
Granuloma Sperm | 2 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + +|
Atrophy | 4 4 2 4 4 2 4 2 4 2 |
Inflammation, Chronic Active | 3 2 3 2 3 2 2 2 |
Duct, Dilatation | 4 4 3 2 3 3 3 4 4 3 4 4 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 7| 3| 7| 4| 6| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 3| 8| 3| 5| 2| 6| 3| 8| 3| 5| 3| 3| 3| 1| 6| 2| 2| 3| 3| 3| 3|
| 8| 5| 0| 0| 0| 6| 0| 9| 3| 6| 0| 4| 1| 9| 1| 1| 1| 9| 5| 9| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
Femoral, Necrosis, Coagulative | |
Thoracic, Vertebra, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + M + + + + + M + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 4 3 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + M M + + +|
Cyst | X X |
Hyperplasia, Lymphoid | |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M + M M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | 3 |
Humerus, Joint, Cartilage, | |
Hyperplasia, Focal | |
Intervertebral Disc, Degeneration | 2 2 |
Joint, Cartilage, Tibia, Degeneration| 2 |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 116
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 7| 3| 7| 4| 6| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 3| 8| 3| 5| 2| 6| 3| 8| 3| 5| 3| 3| 3| 1| 6| 2| 2| 3| 3| 3| 3|
| 8| 5| 0| 0| 0| 6| 0| 9| 3| 6| 0| 4| 1| 9| 1| 1| 1| 9| 5| 9| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic Active | 3 |
Leukocytosis | |
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + M + + + M + M + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | |
Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | 2 |
Nephropathy, Chronic | 1 2 2 2 1 3 2 2 1 2 2 2 3 1 3 2 2 1|
Pelvis, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 4| 7| 1| 7| 7| 7| 1| 1| 4| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 2| 3| 3| 2| 3| 6| 2| 3| 8| 3| 6| 1| 3| 3| 6| 6| 5| 7| 3| 2| 2| 5| 3|
| 1| 9| 9| 1| 2| 9| 2| 6| 9| 2| 8| 2| 5| 4| 2| 2| 6| 5| 9| 3| 2| 9| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X X X X X X X X|
Eosinophilic Focus | |
Mineralization | |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 2 |
Vacuolization Cytoplasmic | 3 2 2 2 2 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Concretion | 1 |
Dentine, Incisor, Dysplasia | 2 2 4 3 3 1 3 4 4 4 1 2 4 4 1 2 3 3 4 3|
Dentine, Incisor, Necrosis | 4 |
Incisor, Lower, Dysplasia | 3 3 3 2|
Incisor, Ameloblast, Atrophy | 4 4 3 3 4 4 4 3 3 3 4 3 4|
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 4| 7| 1| 7| 7| 7| 1| 1| 4| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 2| 3| 3| 2| 3| 6| 2| 3| 8| 3| 6| 1| 3| 3| 6| 6| 5| 7| 3| 2| 2| 5| 3|
| 1| 9| 9| 1| 2| 9| 2| 6| 9| 2| 8| 2| 5| 4| 2| 2| 6| 5| 9| 3| 2| 9| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 2 2 |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 |
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 4 2 4 4 4 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Atrophy | |
Granuloma Sperm | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Atrophy | 3 4 |
Inflammation, Chronic Active | 3 2 2 |
Duct, Dilatation | 2 2 3 3 3 4 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 4| 7| 1| 7| 7| 7| 1| 1| 4| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 2| 3| 3| 2| 3| 6| 2| 3| 8| 3| 6| 1| 3| 3| 6| 6| 5| 7| 3| 2| 2| 5| 3|
| 1| 9| 9| 1| 2| 9| 2| 6| 9| 2| 8| 2| 5| 4| 2| 2| 6| 5| 9| 3| 2| 9| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 1 |
Femoral, Necrosis, Coagulative | |
Thoracic, Vertebra, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M + M + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Lymphoid | |
Thymocyte, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + M M M M M M M + M M M M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | |
Humerus, Joint, Cartilage, | |
Hyperplasia, Focal | 3 |
Intervertebral Disc, Degeneration | 3 |
Joint, Cartilage, Tibia, Degeneration| |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | 4 |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 4| 7| 1| 7| 7| 7| 1| 1| 4| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 2| 3| 3| 2| 3| 6| 2| 3| 8| 3| 6| 1| 3| 3| 6| 6| 5| 7| 3| 2| 2| 5| 3|
| 1| 9| 9| 1| 2| 9| 2| 6| 9| 2| 8| 2| 5| 4| 2| 2| 6| 5| 9| 3| 2| 9| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
Leukocytosis | |
Mineralization | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + + M + + + M + + + + + M + + + + + + + + M M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X|
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 1 2 1 2 2 2 2 2 1 2 1 2 2 1 1 2 2 1|
Pelvis, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 5| 3| 2| 3| 6| 3| 3| 0| 2| 0| 3| 3|
| 2| 6| 7| 2| 3| 3| 8| 3| 3| 3| 4| 3| 3| 8| 3| 9| 3| 6| 3| 6| 5| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X X X X X X|
Eosinophilic Focus | X X |
Mineralization | 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 3 2 2 1 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | |
Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Concretion | |
Dentine, Incisor, Dysplasia | 3 1 1 3 4 1 1 2 1 3 2 1 1 4 4 3 3 4 3 3 1|
Dentine, Incisor, Necrosis | 4 |
Incisor, Lower, Dysplasia | 3 3 3 3 3 |
Incisor, Ameloblast, Atrophy | 3 4 3 4 3 3 4 4 4 4 4 3 3 |
Peridontal Tissue, Incisor, | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 5| 3| 2| 3| 6| 3| 3| 0| 2| 0| 3| 3|
| 2| 6| 7| 2| 3| 3| 8| 3| 3| 3| 4| 3| 3| 8| 3| 9| 3| 6| 3| 6| 5| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 2 2 |
Hypertrophy | 2 2 2 2 2 2 2 2 2|
Bilateral, Capsule, Spindle Cell, | |
Hyperplasia | 4 |
Capsule, Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 1 3 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Atrophy | |
Granuloma Sperm | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Atrophy | 3 4 2 2 2 4 2 2 2 2 4 3 2 |
Inflammation, Chronic Active | 3 4 3 4 3 |
Duct, Dilatation | 3 3 3 3 4 4 4 3 4 3 2 4 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 5| 3| 2| 3| 6| 3| 3| 0| 2| 0| 3| 3|
| 2| 6| 7| 2| 3| 3| 8| 3| 3| 3| 4| 3| 3| 8| 3| 9| 3| 6| 3| 6| 5| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
Femoral, Necrosis, Coagulative | 4 |
Thoracic, Vertebra, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + M + + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + M + + + + M + M + + M + + +|
Cyst | X X X |
Hyperplasia, Lymphoid | 4 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M + M M M + M + M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | |
Humerus, Joint, Cartilage, | |
Hyperplasia, Focal | |
Intervertebral Disc, Degeneration | 2 2 |
Joint, Cartilage, Tibia, Degeneration| 4 |
Rib, Cartilage, Degeneration | |
Thoracic, Vertebra, Osteosclerosis | 4 4 |
Tibia, Osteosclerosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
_____________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 5| 3| 2| 3| 6| 3| 3| 0| 2| 0| 3| 3|
| 2| 6| 7| 2| 3| 3| 8| 3| 3| 3| 4| 3| 3| 8| 3| 9| 3| 6| 3| 6| 5| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
175 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 2 |
Leukocytosis | X |
Mineralization | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | M M + M + M + + + + + + + + + + M + + M + + + M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 2 1 1 2 1 2 2 2 2 1 2 2 1 1 1 1 2 1|
Pelvis, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 2| 6| 9| 3| 3| 3| 3| 9| 3| 5| 3| 3| 2| 3| 3| |
| 6| 6| 6| 6| 9| 6| 6| 9| 6| 7| 9| 6| 3| 7| 7| 7| 7| 1| 7| 8| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Basophilic Focus | X X| 5 |
Clear Cell Focus | X X X X X X X X X X X X X X X | 48 |
Eosinophilic Focus | X X X X | 6 |
Mineralization | | 1 1.0|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative | | 4 2.3|
Vacuolization Cytoplasmic | 2 3 2 2 2 2 2 1 2 2 | 27 1.9|
__________________________________________________________________________|____________|
Mesentery | +| 4 |
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Necrotizing | 4| 2 4.0|
Mineralization | 2| 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + + + +| 99 |
Cyst Epithelial Inclusion | | 1 |
Diverticulum | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Erosion | | 2 2.0|
Mineralization | 1 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 90 |
Dentine, Incisor, Concretion | | 1 1.0|
Dentine, Incisor, Dysplasia | 2 2 1 4 2 1 3 4 4 1 3 1 2 4 1 4 4 2 1 3 3 1| 82 2.5|
Dentine, Incisor, Necrosis | | 2 4.0|
Incisor, Lower, Dysplasia | 3 4 3 | 14 2.9|
Incisor, Ameloblast, Atrophy | 4 3 4 4 4 3 4 4 4 4 3 | 50 3.5|
Peridontal Tissue, Incisor, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 2| 6| 9| 3| 3| 3| 3| 9| 3| 5| 3| 3| 2| 3| 3| |
| 6| 6| 6| 6| 9| 6| 6| 9| 6| 7| 9| 6| 3| 7| 7| 7| 7| 1| 7| 8| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
Aorta, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cardiomyopathy, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 3 2 2 | 7 2.1|
Hypertrophy | 2 2 2 2 3 2 2 2| 32 2.0|
Bilateral, Capsule, Spindle Cell, | | |
Hyperplasia | 4 | 2 4.0|
Capsule, Spindle Cell, Hyperplasia | 3 2 4 4 | 13 3.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hyperplasia | 2 2 2 2 | 15 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + I + + + + + +| 93 |
Pars Distalis, Cyst | X X| 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ultimobranchial Cyst | X | 1 |
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 | 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + M + + + + + + + + + + + + + + + + + + + + + +| 99 |
Aspermia | 3 | 2 3.0|
Atrophy | | 2 3.0|
Granuloma Sperm | 2 | 4 2.5|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 2| 6| 9| 3| 3| 3| 3| 9| 3| 5| 3| 3| 2| 3| 3| |
| 6| 6| 6| 6| 9| 6| 6| 9| 6| 7| 9| 6| 3| 7| 7| 7| 7| 1| 7| 8| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + +| 55 |
Atrophy | 2 2 2 2 4 2 2 4 2 2| 35 2.8|
Inflammation, Chronic Active | 2 3 4 3 2 2 2 2 4 | 25 2.7|
Duct, Dilatation | 3 3 3 3 3 2 3 4 3 2 3 3 2| 47 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Atrophy | | 2 4.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + M + + + + + + + + + + + + + + + + + + + + + +| 99 |
Seminiferous Tubule, Atrophy | | 2 4.0|
Seminiferous Tubule, Degeneration | 2 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Femoral, Myelofibrosis | | 2 1.5|
Femoral, Necrosis, Coagulative | | 1 4.0|
Thoracic, Vertebra, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 92 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Atrophy | | 2 3.0|
Hematopoietic Cell Proliferation | 3 3 3 2 | 9 2.9|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + + + M + + + + + + + + + + +| 85 |
Cyst | X X X X | 11 |
Hyperplasia, Lymphoid | | 1 4.0|
Thymocyte, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M + M M M M M M M + M + M M M M M M M M M| 16 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 90 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 2| 6| 9| 3| 3| 3| 3| 9| 3| 5| 3| 3| 2| 3| 3| |
| 6| 6| 6| 6| 9| 6| 6| 9| 6| 7| 9| 6| 3| 7| 7| 7| 7| 1| 7| 8| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Calvarium, Hyperostosis | | 1 3.0|
Humerus, Joint, Cartilage, | | |
Hyperplasia, Focal | | 1 3.0|
Intervertebral Disc, Degeneration | 1 3 2 | 8 2.1|
Joint, Cartilage, Tibia, Degeneration| | 2 3.0|
Rib, Cartilage, Degeneration | 3 3 | 2 3.0|
Thoracic, Vertebra, Osteosclerosis | | 3 4.0|
Tibia, Osteosclerosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic Active | 2 2 | 4 2.3|
Leukocytosis | | 1 |
Mineralization | | 1 2.0|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + M + + + + M + + + + + + + + + + + + M M + M M +| 75 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cyst | X X X X X | 11 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 73 1.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 05131-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 2| 6| 9| 3| 3| 3| 3| 9| 3| 5| 3| 3| 2| 3| 3| |
| 6| 6| 6| 6| 9| 6| 6| 9| 6| 7| 9| 6| 3| 7| 7| 7| 7| 1| 7| 8| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| A |
175 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 2 1 1 1 1 1 1 2 1 2 2 2 1 1 2 1 1 1 1 2 2| 78 1.6|
Pelvis, Bacterium | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
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