TR 393 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
SODIUM FLUORIDE
NTP Experiment-Test: 05131-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7681-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 50 70 70 100
Scheduled Sacrifice 20 20 20 19
Early Deaths
Natural Death 10 4 11 6 10
Moribund Sacrifice 11 7 8 10 17
Survivors
Terminal Sacrifice 59 18 31 34 54
Special Control 21
Animals Examined Microscopically 100 32 70 70 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (100) (32) (60) (60) (100)
Necrosis 1 (2%)
Intestine Small, Jejunum (100) (32) (60) (60) (100)
Inflammation, Chronic 1 (2%)
Liver (100) (32) (60) (60) (100)
Angiectasis 1 (1%) 1 (2%)
Basophilic Focus 55 (55%) 13 (41%) 38 (63%) 33 (55%) 52 (52%)
Clear Cell Focus 13 (13%) 1 (3%) 8 (13%) 9 (15%) 8 (8%)
Congestion 1 (1%) 1 (2%) 2 (3%)
Eosinophilic Focus 4 (4%) 1 (3%) 6 (10%) 7 (12%) 9 (9%)
Hepatodiaphragmatic Nodule 8 (8%) 5 (16%) 8 (13%) 10 (17%) 15 (15%)
Hepatodiaphragmatic Nodule, Multiple 1 (2%) 1 (1%)
Hyperplasia 1 (1%) 2 (3%) 3 (5%)
Inflammation, Chronic Active 23 (23%) 11 (34%) 17 (28%) 16 (27%) 24 (24%)
Mixed Cell Focus 1 (2%) 2 (2%)
Vacuolization Cytoplasmic 11 (11%) 6 (19%) 8 (13%) 7 (12%) 19 (19%)
Bile Duct, Hyperplasia 25 (25%) 12 (38%) 14 (23%) 18 (30%) 23 (23%)
Centrilobular, Necrosis 1 (1%) 1 (2%) 1 (2%)
Hepatocyte, Degeneration, Cystic 1 (2%)
Mesentery (4) (1) (3) (2) (2)
Inflammation, Chronic Active 1 (25%)
Fat, Congestion, Acute 1 (50%)
Fat, Inflammation, Chronic Active 3 (75%) 2 (67%) 2 (100%)
Pancreas (100) (32) (60) (60) (99)
Acinus, Atrophy 21 (21%) 6 (19%) 10 (17%) 7 (12%) 21 (21%)
Acinus, Cytomegaly, Focal 1 (2%)
Artery, Inflammation, Chronic Active 1 (1%)
Pharynx (1) (2) (1)
Hyperplasia, Squamous 1 (50%)
Salivary Glands (100) (32) (60) (59) (97)
Acinus, Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Cytomegaly 1 (1%)
Stomach, Forestomach (100) (32) (60) (60) (100)
Acanthosis 4 (4%) 1 (3%) 3 (5%) 2 (3%) 3 (3%)
Inflammation, Chronic Active 1 (2%) 2 (2%)
Ulcer 1 (1%) 3 (5%) 3 (5%) 6 (6%)
Stomach, Glandular (100) (32) (60) (60) (100)
Cyst Epithelial Inclusion 1 (1%)
Erosion 1 (2%)
Hyperplasia 1 (1%)
Mineralization 1 (1%)
Necrosis 2 (2%) 2 (6%) 1 (2%) 1 (2%) 3 (3%)
Pigmentation 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 1 (1%)
Ulcer 1 (3%) 1 (2%) 1 (2%) 3 (3%)
Tongue (1) (1) (1)
Hyperplasia, Squamous 1 (100%) 1 (100%) 1 (100%)
Tooth (98) (31) (70) (70) (100)
Dentine, Dentine, Incisor, Incisor, Necrosis,
Multifocal, Multifocal 1 (1%)
Dentine, Incisor, Dysplasia 2 (6%) 8 (11%) 4 (6%) 10 (10%)
Dentine, Incisor, Necrosis, Focal 5 (5%) 4 (6%) 4 (4%)
Dentine, Incisor, Necrosis, Multifocal 54 (55%) 16 (52%) 34 (49%) 26 (37%) 53 (53%)
Incisor, Odontoblast, Degeneration 2 (2%)
Incisor, Ameloblast, Degeneration 1 (1%) 7 (7%)
Peridontal Tissue, Incisor, Inflammation,
Necrotizing 1 (1%)
Peridontal Tissue, Incisor, Lower,
Inflammation, Chronic, Suppurative 1 (1%)
Peridontal Tissue, Molar, Inflammation,
Suppurative 3 (3%) 2 (3%) 4 (4%)
Peridontal Tissue, Molar, Lower,
Inflammation, Chronic, Suppurative 20 (20%) 5 (16%) 7 (10%) 10 (14%) 21 (21%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (100) (32) (60) (60) (100)
Degeneration, Chronic 69 (69%) 18 (56%) 46 (77%) 43 (72%) 69 (69%)
Inflammation, Chronic Active 1 (1%)
Thrombosis 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (100) (32) (60) (60) (100)
Accessory Adrenal Cortical Nodule 1 (1%) 1 (2%) 1 (1%)
Angiectasis 1 (2%)
Congestion 1 (1%)
Degeneration, Cystic 5 (5%) 1 (2%) 1 (2%) 3 (3%)
Hyperplasia 17 (17%) 2 (6%) 13 (22%) 18 (30%) 15 (15%)
Hypertrophy 3 (3%) 1 (3%) 5 (8%) 5 (8%) 10 (10%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic, Focal 7 (7%) 1 (2%) 2 (3%) 7 (7%)
Bilateral, Degeneration, Cystic 1 (2%)
Bilateral, Hyperplasia 1 (1%)
Adrenal Gland, Medulla (100) (32) (59) (60) (100)
Angiectasis 1 (2%)
Cyst 1 (1%)
Hemorrhage 1 (1%)
Hyperplasia 3 (3%) 3 (5%) 8 (13%) 6 (6%)
Hypertrophy 1 (2%)
Islets, Pancreatic (100) (32) (60) (60) (99)
Hyperplasia 1 (1%)
Pituitary Gland (99) (32) (60) (60) (100)
Pars Distalis, Congestion 21 (21%) 1 (3%) 12 (20%) 17 (28%) 22 (22%)
Pars Distalis, Cyst 20 (20%) 6 (19%) 23 (38%) 17 (28%) 30 (30%)
Pars Distalis, Hemorrhage 1 (1%) 1 (3%) 2 (3%) 5 (5%)
Pars Distalis, Hyperplasia 21 (21%) 7 (22%) 13 (22%) 10 (17%) 19 (19%)
Pars Intermedia, Congestion 1 (2%)
Pars Intermedia, Cyst 2 (2%) 1 (2%) 4 (4%)
Pars Intermedia, Hyperplasia 1 (1%) 1 (2%)
Rathke's Cleft, Cyst 1 (1%)
Thyroid Gland (100) (32) (60) (60) (100)
C-Cell, Hyperplasia 9 (9%) 1 (3%) 6 (10%) 9 (15%) 8 (8%)
Follicle, Cyst 1 (3%) 2 (2%)
Follicular Cell, Hyperplasia 1 (3%) 1 (2%) 4 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (98) (32) (58) (59) (98)
Hyperplasia 1 (1%)
Hyperplasia, Glandular 4 (4%) 1 (3%) 7 (12%) 6 (10%) 6 (6%)
Inflammation, Chronic Active 14 (14%) 2 (6%) 10 (17%) 11 (19%) 18 (18%)
Duct, Cyst 8 (8%) 3 (5%) 3 (5%) 5 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Duct, Hyperplasia, Squamous 2 (2%)
Ovary (100) (32) (60) (60) (100)
Infiltration Cellular, Lymphocyte 1 (2%)
Bilateral, Periovarian Tissue, Cyst 1 (1%)
Follicle, Cyst 1 (1%) 2 (6%) 1 (2%) 1 (1%)
Periovarian Tissue, Cyst 2 (2%) 6 (10%) 3 (5%) 4 (4%)
Periovarian Tissue, Hemorrhage 1 (2%)
Uterus (100) (32) (60) (60) (100)
Hemorrhage 1 (1%)
Infarct, Chronic 1 (2%)
Cervix, Cyst 2 (2%) 1 (3%) 1 (2%) 2 (3%) 4 (4%)
Endometrium, Hyperplasia, Cystic, Glandular 12 (12%) 4 (13%) 13 (22%) 11 (18%) 13 (13%)
Lumen, Hemorrhage 2 (3%)
Vagina (3) (2)
Exudate 1 (33%) 1 (50%)
Prolapse 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (99) (32) (60) (60) (100)
Femoral, Atrophy 1 (2%)
Femoral, Myelofibrosis 1 (2%) 1 (1%)
Lymph Node (100) (32) (60) (60) (100)
Mediastinal, Angiectasis 1 (3%)
Mediastinal, Congestion 1 (1%) 1 (2%)
Renal, Angiectasis 1 (3%)
Renal, Pigmentation, Hemosiderin 1 (3%)
Lymph Node, Mandibular (100) (32) (60) (59) (100)
Congestion 3 (5%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (100) (31) (60) (59) (100)
Angiectasis 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%) 1 (2%)
Inflammation, Chronic Active 1 (1%)
Spleen (100) (32) (60) (60) (100)
Depletion Lymphoid 1 (2%) 1 (2%) 2 (2%)
Fibrosis 2 (2%) 1 (3%) 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 1 (1%) 1 (2%) 1 (1%)
Hyperplasia, Lymphoid, Nodular 1 (1%)
Hyperplasia, Reticulum Cell 2 (2%) 1 (2%)
Infiltration Cellular, Lipocyte 1 (1%)
Inflammation, Granulomatous 1 (1%)
Necrosis 2 (2%) 1 (2%)
Thrombosis 1 (1%)
Capsule, Fibrosis 1 (2%) 1 (1%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (90) (29) (58) (56) (95)
Depletion Lymphoid 62 (69%) 10 (34%) 42 (72%) 43 (77%) 73 (77%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (99) (31) (60) (60) (99)
Hyperplasia, Cystic 81 (82%) 24 (77%) 51 (85%) 52 (87%) 77 (78%)
Mineralization 1 (1%)
Skin (99) (32) (60) (59) (100)
Ulcer 1 (1%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (32) (70) (70) (100)
Cranium, Osteosclerosis 1 (1%)
Femur, Fibrous Osteodystrophy 1 (1%)
Femur, Osteosclerosis 1 (1%)
Humerus, Fibrous Osteodystrophy 1 (1%)
Humerus, Osteosclerosis 4 (4%) 4 (13%) 5 (7%) 4 (6%) 11 (11%)
Joint, Cartilage, Tibia, Degeneration 1 (1%)
Mandible, Fibrous Osteodystrophy 1 (1%)
Maxilla, Fibrous Osteodystrophy 1 (3%)
Maxilla, Osteosclerosis 2 (3%) 3 (3%)
Thoracic, Vertebra, Fibrous Osteodystrophy 1 (1%)
Thoracic, Vertebra, Osteosclerosis 5 (5%) 1 (3%) 7 (10%) 5 (7%) 15 (15%)
Tibia, Fibrous Osteodystrophy 1 (1%)
Tibia, Osteosclerosis 6 (6%) 2 (6%) 11 (16%) 9 (13%) 15 (15%)
Vertebra, Osteosclerosis 1 (1%)
Skeletal Muscle (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (32) (60) (60) (100)
Compression 6 (6%) 2 (6%) 4 (7%) 7 (12%) 10 (10%)
Hemorrhage 1 (1%) 1 (1%)
Hydrocephalus 5 (5%) 1 (3%) 3 (5%) 5 (8%) 6 (6%)
Necrosis 1 (1%)
Spinal Cord (1)
Myelin, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (32) (60) (60) (100)
Foreign Body 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (3%) 1 (3%) 4 (7%) 2 (3%) 5 (5%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Nose (100) (32) (60) (60) (100)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Metaplasia, Squamous 1 (1%) 2 (3%) 1 (2%)
Mucosa, Inflammation, Acute 2 (2%) 1 (3%) 1 (2%) 1 (1%)
Mucosa, Inflammation, Chronic Active 12 (12%) 4 (13%) 7 (12%) 5 (8%) 18 (18%)
Mucosa, Ulcer 2 (2%) 2 (2%)
Sinus, Foreign Body 6 (6%) 2 (6%) 5 (8%) 4 (7%) 15 (15%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (2)
Pinna, Inflammation, Chronic Active 1 (50%)
Eye (21) (5) (10) (13) (26)
Anterior Chamber, Hemorrhage 1 (5%) 1 (4%)
Cornea, Inflammation, Acute 1 (4%)
Lens, Cataract 19 (90%) 5 (100%) 10 (100%) 13 (100%) 25 (96%)
Retina, Atrophy 19 (90%) 5 (100%) 10 (100%) 13 (100%) 25 (96%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (32) (60) (60) (100)
Hydronephrosis 1 (1%)
Inflammation, Acute, Focal 1 (2%)
Nephropathy, Chronic 84 (84%) 27 (84%) 58 (97%) 55 (92%) 82 (82%)
Cortex, Cyst 1 (1%) 1 (3%)
Cortex, Infarct, Chronic, Multifocal 1 (1%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Inflammation, Chronic Active 1 (2%)
Renal Tubule, Mineralization 9 (9%) 2 (2%)
Urinary Bladder (100) (32) (59) (60) (100)
Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 50 70 70 100
Scheduled Sacrifice 19 19 20 20
Early Deaths
Moribund Sacrifice 21 12 13 13 19
Natural Death 17 6 13 13 19
Accidently Killed 1
Survivors
Terminal Sacrifice 42 5 25 23 42
Special Control 27
Wrong Sex 1
Animals Examined Microscopically 99 45 70 70 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (98) (45) (59) (60) (100)
Congestion 1 (1%)
Ulcer 1 (2%)
Intestine Large, Colon (98) (45) (60) (60) (100)
Ulcer 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Intestine Large, Rectum (98) (45) (60) (60) (100)
Parasite Metazoan 1 (1%) 1 (1%)
Muscularis, Inflammation, Chronic Active 1 (1%)
Intestine Small, Duodenum (99) (45) (60) (60) (100)
Ulcer 1 (2%)
Intestine Small, Jejunum (99) (45) (60) (60) (100)
Inflammation, Chronic Active, Granulomatous 1 (2%)
Liver (99) (45) (60) (60) (100)
Angiectasis 2 (4%) 2 (2%)
Basophilic Focus 18 (18%) 5 (11%) 23 (38%) 15 (25%) 24 (24%)
Clear Cell Focus 23 (23%) 2 (4%) 19 (32%) 17 (28%) 20 (20%)
Congestion 2 (3%) 1 (1%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 5 (5%) 1 (2%) 3 (5%) 3 (5%) 5 (5%)
Hepatodiaphragmatic Nodule 7 (7%) 6 (13%) 5 (8%) 5 (8%) 9 (9%)
Hyperplasia 4 (4%) 1 (2%) 3 (5%) 3 (5%) 9 (9%)
Infarct 1 (2%)
Inflammation, Chronic Active 13 (13%) 3 (7%) 11 (18%) 10 (17%) 10 (10%)
Mixed Cell Focus 3 (5%) 1 (1%)
Necrosis 2 (2%)
Vacuolization Cytoplasmic 32 (32%) 28 (62%) 25 (42%) 21 (35%) 31 (31%)
Bile Duct, Hyperplasia 73 (74%) 37 (82%) 48 (80%) 48 (80%) 76 (76%)
Centrilobular, Vacuolization Cytoplasmic 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Cytomegaly, Focal 1 (2%)
Hepatocyte, Degeneration, Cystic 13 (13%) 3 (7%) 8 (13%) 10 (17%) 14 (14%)
Serosa, Fibrosis 1 (2%) 1 (1%)
Subserosa, Congestion 1 (2%)
Mesentery (13) (6) (9) (5) (18)
Artery, Thrombosis 1 (20%)
Fat, Hemorrhage 1 (17%)
Fat, Inflammation, Chronic Active 12 (92%) 4 (67%) 7 (78%) 2 (40%) 17 (94%)
Pancreas (98) (45) (59) (60) (99)
Acinus, Atrophy 34 (35%) 18 (40%) 18 (31%) 22 (37%) 20 (20%)
Acinus, Hyperplasia 1 (1%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 5 (5%) 2 (4%) 5 (8%) 6 (6%)
Duct, Cyst 2 (3%)
Duct, Hyperplasia 1 (1%)
Vein, Thrombosis 1 (1%)
Salivary Glands (99) (45) (59) (60) (100)
Acinus, Atrophy 1 (1%)
Stomach, Forestomach (98) (45) (60) (60) (100)
Acanthosis 9 (9%) 2 (4%) 3 (5%) 4 (7%) 2 (2%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic Active 3 (3%) 1 (2%) 1 (2%) 2 (2%)
Mineralization 1 (1%)
Ulcer 8 (8%) 3 (7%) 8 (13%) 3 (5%) 3 (3%)
Submucosa, Ectopic Tissue 1 (2%)
Stomach, Glandular (98) (45) (60) (59) (100)
Cyst Epithelial Inclusion 1 (2%)
Dysplasia 2 (2%)
Erosion 1 (2%)
Hyperplasia 1 (1%)
Inflammation, Chronic Active 1 (2%)
Mineralization 3 (3%) 1 (2%) 2 (3%) 1 (1%)
Necrosis 4 (4%) 3 (5%) 3 (5%) 6 (6%)
Pigmentation, Hemosiderin 3 (5%) 4 (7%) 2 (2%)
Ulcer 7 (7%) 3 (7%) 3 (5%) 1 (2%) 1 (1%)
Tongue (2)
Mucosa, Hyperplasia, Squamous 1 (50%)
Tooth (99) (45) (70) (70) (99)
Dentine, Incisor, Dysplasia 4 (4%) 7 (10%) 14 (20%) 31 (31%)
Dentine, Incisor, Necrosis, Focal 1 (1%)
Dentine, Incisor, Necrosis, Multifocal 75 (76%) 33 (73%) 42 (60%) 44 (63%) 73 (74%)
Incisor, Odontoblast, Degeneration 1 (1%) 2 (3%) 4 (4%)
Incisor, Ameloblast, Degeneration 1 (1%) 7 (10%) 24 (24%)
Peridontal Tissue, Fibrosis 1 (1%)
Peridontal Tissue, Inflammation, Chronic 1 (1%)
Peridontal Tissue, Incisor, Inflammation,
Suppurative 2 (2%)
Peridontal Tissue, Molar, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Chronic, Suppurative 1 (1%) 1 (1%)
Peridontal Tissue, Molar, Inflammation,
Suppurative 4 (4%) 1 (1%) 2 (2%)
Peridontal Tissue, Molar, Lower,
Inflammation, Chronic, Suppurative 27 (27%) 22 (49%) 21 (30%) 19 (27%) 33 (33%)
Pulp, Incisor, Inflammation, Chronic,
Necrotizing 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (99) (45) (60) (60) (100)
Degeneration, Chronic 91 (92%) 35 (78%) 55 (92%) 52 (87%) 84 (84%)
Mineralization 2 (2%) 1 (2%)
Thrombosis 6 (6%) 1 (2%) 2 (3%) 3 (5%) 4 (4%)
Atrium, Dilatation 1 (2%) 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (99) (45) (60) (60) (100)
Capsule, Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Cortex (99) (45) (60) (60) (100)
Accessory Adrenal Cortical Nodule 1 (1%)
Congestion 1 (2%)
Hemorrhage 1 (1%)
Hyperplasia 10 (10%) 3 (7%) 12 (20%) 12 (20%) 12 (12%)
Hypertrophy 1 (2%) 2 (3%) 4 (4%)
Vacuolization Cytoplasmic, Focal 6 (6%) 1 (2%) 3 (5%) 6 (10%) 8 (8%)
Bilateral, Degeneration, Cystic, Focal 1 (2%)
Adrenal Gland, Medulla (98) (45) (60) (60) (100)
Hemorrhage 1 (1%)
Hyperplasia 33 (34%) 11 (24%) 21 (35%) 17 (28%) 28 (28%)
Islets, Pancreatic (98) (45) (58) (60) (100)
Hyperplasia 1 (1%) 3 (5%) 1 (2%) 2 (2%)
Parathyroid Gland (96) (43) (60) (59) (95)
Hyperplasia 1 (1%) 2 (3%) 1 (1%)
Pituitary Gland (99) (44) (59) (59) (100)
Pars Distalis, Congestion 2 (2%) 3 (5%) 5 (8%) 6 (6%)
Pars Distalis, Cyst 6 (6%) 2 (5%) 4 (7%) 4 (7%) 2 (2%)
Pars Distalis, Hemorrhage 3 (3%) 1 (2%) 1 (1%)
Pars Distalis, Hyperplasia 17 (17%) 6 (14%) 12 (20%) 9 (15%) 9 (9%)
Pars Distalis, Inflammation, Chronic Active 1 (1%)
Pars Distalis, Karyomegaly 1 (1%)
Pars Distalis, Vacuolization Cytoplasmic,
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Focal 1 (2%)
Pars Intermedia, Cyst 3 (3%) 2 (5%) 1 (2%) 2 (3%) 2 (2%)
Thyroid Gland (99) (45) (60) (60) (100)
Metaplasia, Osseous 1 (1%)
C-Cell, Hyperplasia 5 (5%) 3 (7%) 4 (7%) 6 (10%) 10 (10%)
Follicle, Cyst 2 (2%) 1 (2%) 2 (3%) 2 (2%)
Follicular Cell, Hyperplasia 2 (2%) 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (1)
Hemorrhage 1 (100%)
Epididymis (99) (45) (60) (60) (100)
Dilatation 2 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (1%)
Preputial Gland (99) (45) (60) (57) (100)
Hyperplasia 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Hyperplasia, Glandular 1 (2%) 1 (2%) 1 (1%)
Inflammation, Chronic Active 54 (55%) 30 (67%) 46 (77%) 40 (70%) 66 (66%)
Duct, Cyst 4 (4%) 1 (2%) 5 (8%) 4 (7%) 6 (6%)
Prostate (98) (45) (59) (59) (100)
Atrophy 1 (1%)
Dilatation 4 (4%) 1 (2%) 1 (2%) 4 (4%)
Hyperplasia 1 (1%)
Inflammation, Chronic Active 29 (30%) 11 (24%) 18 (31%) 13 (22%) 17 (17%)
Seminal Vesicle (97) (45) (60) (59) (97)
Atrophy 2 (2%) 3 (3%)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (1%)
Testes (99) (45) (60) (60) (100)
Interstitial Cell, Hyperplasia 39 (39%) 30 (67%) 24 (40%) 24 (40%) 39 (39%)
Seminiferous Tubule, Atrophy 20 (20%) 5 (11%) 5 (8%) 10 (17%) 10 (10%)
Serosa, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (98) (45) (60) (60) (100)
Femoral, Atrophy 1 (2%)
Femoral, Myelofibrosis 2 (2%)
Lymph Node (98) (45) (60) (60) (100)
Mediastinal, Congestion 1 (2%)
Mediastinal, Depletion Lymphoid 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Inflammation, Acute 1 (2%)
Renal, Angiectasis 1 (1%)
Renal, Congestion 1 (1%)
Lymph Node, Mandibular (98) (45) (59) (60) (100)
Angiectasis 1 (1%) 2 (3%) 2 (2%)
Congestion 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (1%)
Inflammation, Chronic Active 1 (2%)
Lymph Node, Mesenteric (97) (45) (59) (59) (96)
Angiectasis 1 (2%) 1 (2%) 1 (1%)
Congestion 1 (1%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Spleen (98) (45) (60) (60) (100)
Depletion Lymphoid 1 (1%) 1 (2%) 1 (2%) 1 (2%)
Fibrosis 10 (10%) 2 (4%) 7 (12%) 9 (15%) 9 (9%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (1%)
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 1 (2%) 1 (1%)
Capsule, Cyst, Multiple 1 (2%)
Red Pulp, Atrophy 1 (1%) 1 (2%)
Thymus (88) (43) (57) (51) (96)
Depletion Lymphoid 54 (61%) 19 (44%) 42 (74%) 38 (75%) 66 (69%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (92) (43) (57) (57) (92)
Hemorrhage 1 (1%)
Hyperplasia, Cystic 87 (95%) 37 (86%) 55 (96%) 56 (98%) 84 (91%)
Duct, Hemorrhage 1 (1%)
Skin (99) (45) (60) (60) (100)
Acanthosis 1 (1%)
Cyst Epithelial Inclusion 2 (3%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%)
Sebaceous Gland, Cyst 1 (2%)
Subcutaneous Tissue, Foreign Body 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%) 1 (2%) 2 (2%)
Subcutaneous Tissue, Metaplasia, Osseous 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (99) (45) (70) (70) (99)
Epiphysis, Tibia, Cyst 1 (1%) 1 (1%)
Epiphysis, Tibia, Cyst, Multifocal 1 (1%)
Femur, Fibrous Osteodystrophy 1 (1%)
Femur, Osteosclerosis 1 (1%)
Humerus, Fibrous Osteodystrophy 8 (8%) 2 (4%) 6 (9%) 8 (11%) 2 (2%)
Humerus, Osteoporosis 1 (1%)
Humerus, Osteosclerosis 4 (4%) 1 (2%) 1 (1%) 1 (1%)
Humerus, Joint, Cartilage, Degeneration 1 (1%) 1 (1%) 1 (1%)
Humerus, Joint, Cartilage, Degeneration,
Focal 1 (1%) 1 (1%)
Humerus, Joint, Cartilage, Necrosis, Focal 1 (1%) 1 (1%) 1 (1%)
Humerus, Epiphysis, Cyst 1 (1%)
Humerus, Ligament, Metaplasia, Cartilagenous,
Focal 1 (1%)
Joint, Cartilage, Tibia, Degeneration 1 (1%) 2 (2%)
Joint, Cartilage, Tibia, Necrosis, Focal 1 (1%)
Mandible, Fibrous Osteodystrophy 1 (1%) 2 (4%) 1 (1%) 3 (4%) 1 (1%)
Maxilla, Fibrous Osteodystrophy 7 (7%) 2 (4%) 5 (7%) 4 (6%) 1 (1%)
Maxilla, Fibrous Osteodystrophy, Multifocal 1 (1%)
Thoracic, Periosteum, Vertebra, Hyperostosis 1 (1%)
Thoracic, Vertebra, Fibrous Osteodystrophy 7 (7%) 1 (2%) 3 (4%) 6 (9%) 3 (3%)
Thoracic, Vertebra, Osteosclerosis 1 (1%)
Thoracic, Vertebra, Intervertebral Disc,
Degeneration 1 (1%)
Tibia, Fibrous Osteodystrophy 10 (10%) 3 (7%) 5 (7%) 5 (7%) 2 (2%)
Tibia, Necrosis, Focal 1 (1%)
Tibia, Osteoporosis 1 (1%)
Tibia, Osteosclerosis 2 (2%) 1 (2%) 1 (1%) 4 (6%) 3 (3%)
Tibia, Thrombosis, Chronic, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (99) (45) (60) (60) (100)
Compression 2 (2%) 1 (2%) 3 (5%) 3 (5%) 2 (2%)
Degeneration 1 (1%)
Hemorrhage 1 (1%)
Hydrocephalus 2 (2%) 2 (3%) 2 (3%) 1 (1%)
Necrosis, Subacute 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Vein, Thrombosis 1 (1%)
Peripheral Nerve (1) (1) (1)
Sciatic, Degeneration 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (99) (45) (60) (60) (100)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (1%) 2 (4%) 2 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Mineralization 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (3%) 2 (4%) 2 (3%) 5 (8%) 3 (3%)
Pleura, Hyperplasia 1 (1%)
Pleura, Inflammation, Chronic Active 1 (2%) 1 (2%)
Nose (99) (45) (60) (60) (100)
Inflammation, Chronic Active 4 (4%) 1 (2%) 3 (5%) 3 (3%)
Metaplasia, Squamous 4 (4%) 1 (2%) 1 (2%) 3 (3%)
Mucosa, Inflammation, Acute 7 (16%) 1 (2%) 2 (3%) 5 (5%)
Mucosa, Inflammation, Chronic Active 25 (25%) 6 (13%) 17 (28%) 14 (23%) 22 (22%)
Mucosa, Ulcer 1 (1%) 3 (7%) 2 (3%) 1 (1%)
Sinus, Foreign Body 20 (20%) 4 (9%) 15 (25%) 11 (18%) 22 (22%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (1) (1) (1)
Pinna, Acanthosis 1 (33%)
Eye (23) (3) (7) (14) (16)
Cornea, Hyperplasia, Squamous 1 (14%)
Cornea, Inflammation, Chronic Active 1 (14%)
Lens, Cataract 21 (91%) 3 (100%) 7 (100%) 14 (100%) 16 (100%)
Retina, Atrophy 22 (96%) 3 (100%) 5 (71%) 14 (100%) 16 (100%)
Harderian Gland (1) (2) (1)
Hyperplasia 1 (50%)
Zymbal's Gland (3) (1) (2) (1) (3)
Cyst, Multiple 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (98) (45) (60) (60) (100)
Hydronephrosis 1 (2%)
Nephropathy, Chronic 97 (99%) 44 (98%) 60 (100%) 60 (100%) 99 (99%)
Cortex, Cyst 3 (3%) 2 (3%) 4 (7%) 2 (2%)
Renal Tubule, Necrosis, Acute, Multifocal 1 (1%)
Renal Tubule, Epithelium, Hyperplasia, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (98) (44) (60) (58) (100)
Calculus Micro Observation Only 1 (1%)
Ectasia 1 (2%)
Mucosa, Hyperplasia 1 (1%)
Submucosa, Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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