TR 393 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
SODIUM FLUORIDE
NTP Experiment-Test: 05131-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7681-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 100 50 70 70 100
Scheduled Sacrifice 20 20 20 19
Early Deaths
Natural Death 10 4 11 6 10
Moribund Sacrifice 11 7 8 10 17
Survivors
Terminal Sacrifice 59 18 31 34 54
Special Control 21
Animals Examined Microscopically 100 32 70 70 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (100) (32) (59) (60) (100)
Adenocarcinoma 1 (3%)
Leiomyosarcoma, Metastatic, Vagina 1 (2%)
Intestine Small, Jejunum (100) (32) (60) (60) (100)
Leiomyoma 1 (1%) 1 (1%)
Liver (100) (32) (60) (60) (100)
Hepatocellular Adenoma 2 (2%) 1 (2%) 1 (1%)
Mesentery (4) (1) (3) (2) (2)
Histiocytic Sarcoma, Metastatic, Skin 1 (50%)
Oral Mucosa (1) (2)
Gingival, Squamous Cell Carcinoma 1 (100%) 2 (100%)
Pancreas (100) (32) (60) (60) (99)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Acinus, Adenoma 1 (1%)
Pharynx (1) (2) (1)
Palate, Squamous Cell Carcinoma 1 (100%)
Palate, Squamous Cell Papilloma 1 (100%) 1 (50%)
Salivary Glands (100) (32) (60) (59) (97)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Stomach, Glandular (100) (32) (60) (60) (100)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (100) (32) (60) (60) (100)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (1%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (100) (32) (60) (60) (100)
Adenoma 1 (1%) 1 (1%)
Adrenal Gland, Medulla (100) (32) (59) (60) (100)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (1%)
Pheochromocytoma Malignant 1 (2%) 1 (1%)
Pheochromocytoma Benign 5 (5%) 2 (3%) 1 (2%) 5 (5%)
Bilateral, Pheochromocytoma Benign 1 (1%)
Islets, Pancreatic (100) (32) (60) (60) (99)
Adenoma 3 (3%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (99) (32) (56) (55) (97)
Adenoma 1 (2%) 1 (1%)
Pituitary Gland (99) (32) (60) (60) (100)
Pars Distalis, Adenoma 32 (32%) 7 (22%) 23 (38%) 21 (35%) 28 (28%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%) 4 (4%)
Pars Distalis, Carcinoma 2 (3%)
Pars Intermedia, Adenoma 1 (2%)
Pars Intermedia, Carcinoma 1 (1%)
Thyroid Gland (100) (32) (60) (60) (100)
Bilateral, C-Cell, Adenoma 1 (1%)
Bilateral, Follicular Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 13 (13%) 7 (22%) 4 (7%) 7 (12%) 12 (12%)
C-Cell, Carcinoma 1 (1%) 1 (2%) 1 (1%)
Follicular Cell, Adenoma 1 (2%) 1 (1%)
Follicular Cell, Carcinoma 2 (2%) 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (98) (32) (58) (59) (98)
Adenoma 9 (9%) 1 (2%) 5 (8%) 11 (11%)
Carcinoma 1 (1%) 1 (2%) 1 (1%)
Bilateral, Adenoma 1 (1%) 1 (2%) 1 (1%)
Bilateral, Carcinoma 1 (2%)
Ovary (100) (32) (60) (60) (100)
Granulosa Cell Tumor Malignant 1 (1%)
Periovarian Tissue, Lymphangioma 1 (3%)
Uterus (100) (32) (60) (60) (100)
Adenoma 1 (2%) 2 (2%)
Hemangioma 1 (1%)
Page 3
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyosarcoma 1 (3%)
Lymphangiosarcoma 1 (1%)
Polyp Stromal 12 (12%) 1 (3%) 4 (7%) 7 (12%) 2 (2%)
Cervix, Carcinoma 1 (1%)
Cervix, Fibroma 1 (1%)
Cervix, Fibrosarcoma 1 (1%)
Cervix, Sarcoma Stromal 1 (1%)
Vagina (3) (2)
Fibrosarcoma 1 (33%)
Leiomyosarcoma 1 (33%) 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (99) (32) (60) (60) (100)
Lymph Node (100) (32) (60) (60) (100)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (1%)
Lymph Node, Mandibular (100) (32) (60) (59) (100)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (100) (31) (60) (59) (100)
Spleen (100) (32) (60) (60) (100)
Thymus (90) (29) (58) (56) (95)
Thymoma Benign 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (99) (31) (60) (60) (99)
Adenocarcinoma 1 (1%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 1 (2%) 1 (2%) 1 (1%)
Fibroadenoma 20 (20%) 6 (19%) 12 (20%) 12 (20%) 19 (19%)
Fibroadenoma, Multiple 2 (2%) 2 (6%) 1 (2%) 3 (5%) 5 (5%)
Skin (99) (32) (60) (59) (100)
Keratoacanthoma 2 (2%)
Keratoacanthoma, Multiple 1 (1%)
Squamous Cell Papilloma 1 (3%)
Trichoepithelioma 1 (1%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (1%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
Subcutaneous Tissue, Granulosa Cell Tumor
Malignant, Metastatic, Ovary 1 (1%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (1%)
Page 4
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Schwannoma Malignant,
Metastatic, Eye 1 (3%)
Sweat Gland, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (32) (60) (60) (100)
Astrocytoma Malignant 1 (1%) 1 (2%) 1 (1%)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
Carcinoma, Metastatic, Zymbal's Gland 1 (1%)
Glioma Malignant 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Oligodendroglioma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (32) (60) (60) (100)
Alveolar/Bronchiolar Adenoma 2 (2%) 1 (2%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (1%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Nose (100) (32) (60) (60) (100)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (2)
Pinna, Fibroma 1 (33%)
Pinna, Fibrosarcoma 2 (67%) 1 (50%)
Eye (21) (5) (10) (13) (26)
Optic Nerve, Schwannoma Malignant 1 (20%)
Harderian Gland (1) (1)
Fibrosarcoma, Metastatic, Skin 1 (100%)
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (32) (60) (60) (100)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (1%)
Mast Cell Tumor Malignant 1 (2%)
Urinary Bladder (100) (32) (59) (60) (100)
Leiomyosarcoma, Metastatic, Vagina 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(100) *(32) *(70) *(70) *(100)
Histiocytic Sarcoma 1 (1%)
Leukemia Mononuclear 26 (26%) 7 (22%) 16 (23%) 14 (20%) 20 (20%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 73 22 45 51 74
Total Primary Neoplasms 148 35 76 91 142
Total Animals with Benign Neoplasms 63 17 39 40 61
Total Benign Neoplasms 108 25 55 64 105
Total Animals with Malignant Neoplasms 38 8 21 25 32
Total Malignant Neoplasms 40 10 21 27 37
Total Animals with Metastatic Neoplasms 1 1 1 5 2
Total Metastatic Neoplasm 5 1 2 13 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 100 50 70 70 100
Scheduled Sacrifice 19 19 20 20
Early Deaths
Moribund Sacrifice 21 12 13 13 19
Natural Death 17 6 13 13 19
Accidently Killed 1
Survivors
Terminal Sacrifice 42 5 25 23 42
Special Control 27
Wrong Sex 1
Animals Examined Microscopically 99 45 70 70 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (98) (45) (60) (60) (100)
Adenocarcinoma 1 (1%)
Intestine Small, Ileum (98) (45) (60) (60) (99)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (99) (45) (60) (60) (100)
Adenocarcinoma 1 (1%)
Leiomyoma 1 (1%)
Liver (99) (45) (60) (60) (100)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Adenoma 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Histiocytic Sarcoma, Multiple 1 (1%)
Mesentery (13) (6) (9) (5) (18)
Histiocytic Sarcoma 1 (20%)
Liposarcoma 1 (11%)
Oral Mucosa (1) (1) (2)
Buccal, Squamous Cell Carcinoma 1 (100%)
Buccal, Squamous Cell Papilloma 1 (50%)
Gingival, Squamous Cell Carcinoma 1 (100%) 1 (50%)
Pancreas (98) (45) (59) (60) (99)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Acinus, Adenoma 1 (2%)
Pharynx (1) (1)
Palate, Squamous Cell Papilloma 1 (100%) 1 (100%)
Salivary Glands (99) (45) (59) (60) (100)
Carcinoma 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Stomach, Forestomach (98) (45) (60) (60) (100)
Basal Cell Adenoma 1 (1%)
Page 8
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (98) (45) (60) (59) (100)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
Tooth (99) (45) (70) (70) (99)
Gingiva, Molar, Lower, Squamous Cell
Carcinoma, Metastatic 1 (1%)
Peridontal Tissue, Squamous Cell Carcinoma,
Metastatic 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (99) (45) (60) (60) (100)
Hemangiosarcoma 1 (1%)
Endocardium, Ventricle Left, Schwannoma
Benign 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (99) (45) (60) (60) (100)
Adenoma 1 (1%) 1 (2%) 1 (1%)
Adrenal Gland, Medulla (98) (45) (60) (60) (100)
Pheochromocytoma Malignant 2 (2%) 1 (2%)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 19 (19%) 6 (13%) 13 (22%) 8 (13%) 22 (22%)
Bilateral, Pheochromocytoma Benign 5 (5%) 2 (4%) 8 (13%) 7 (12%) 8 (8%)
Islets, Pancreatic (98) (45) (58) (60) (100)
Adenoma 2 (2%) 1 (2%) 3 (5%) 4 (4%)
Carcinoma 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Parathyroid Gland (96) (43) (60) (59) (95)
Adenoma 4 (4%) 1 (2%) 1 (2%) 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Pituitary Gland (99) (44) (59) (59) (100)
Pars Distalis, Adenoma 16 (16%) 3 (7%) 9 (15%) 9 (15%) 15 (15%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (99) (45) (60) (60) (100)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%) 1 (2%) 2 (2%)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 14 (14%) 6 (13%) 9 (15%) 9 (15%) 11 (11%)
C-Cell, Carcinoma 1 (1%) 4 (4%)
Follicular Cell, Adenoma 1 (2%) 3 (3%)
Follicular Cell, Carcinoma 1 (1%) 1 (2%) 2 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (1) (2)
Chordoma 1 (50%)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (99) (45) (60) (60) (100)
Preputial Gland (99) (45) (60) (57) (100)
Adenoma 7 (7%) 2 (4%) 5 (8%) 3 (5%) 5 (5%)
Carcinoma 1 (1%) 1 (2%) 3 (5%) 1 (2%) 4 (4%)
Prostate (98) (45) (59) (59) (100)
Seminal Vesicle (97) (45) (60) (59) (97)
Testes (99) (45) (60) (60) (100)
Bilateral, Interstitial Cell, Adenoma 58 (59%) 21 (47%) 39 (65%) 38 (63%) 63 (63%)
Interstitial Cell, Adenoma 14 (14%) 14 (31%) 13 (22%) 14 (23%) 14 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (98) (45) (60) (60) (100)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node (98) (45) (60) (60) (100)
Axillary, Carcinoma, Metastatic, Thyroid
Gland 1 (2%)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (1%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (2%)
Mediastinal, Histiocytic Sarcoma, Metastatic,
Spleen 1 (2%)
Lymph Node, Mandibular (98) (45) (59) (60) (100)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma, Metastatic, Spleen 1 (2%)
Lymph Node, Mesenteric (97) (45) (59) (59) (96)
Histiocytic Sarcoma, Metastatic, Spleen 1 (2%)
Spleen (98) (45) (60) (60) (100)
Fibrosarcoma 1 (1%) 1 (2%)
Fibrous Histiocytoma 1 (2%)
Hemangioma 1 (1%)
Histiocytic Sarcoma 3 (5%)
Thymus (88) (43) (57) (51) (96)
Thymoma Malignant 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (92) (43) (57) (57) (92)
Fibroadenoma 6 (7%) 1 (2%) 2 (2%)
Skin (99) (45) (60) (60) (100)
Basal Cell Adenoma 1 (1%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 8 (8%) 1 (2%) 2 (3%) 2 (3%) 8 (8%)
Keratoacanthoma, Multiple 1 (1%) 1 (2%)
Papilloma 1 (2%) 2 (2%)
Squamous Cell Papilloma 1 (1%) 2 (3%) 1 (2%) 2 (2%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (3%) 3 (5%) 4 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Neurofibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma,
Multiple 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (1%)
Subcutaneous Tissue, Osteosarcoma,
Metastatic, Bone 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (99) (45) (70) (70) (99)
Humerus, Osteosarcoma 1 (1%)
Vertebra, Osteosarcoma 2 (2%)
Vertebra, Coccygeal, Osteosarcoma 1 (1%)
Skeletal Muscle (1) (1) (1) (1)
Diaphragm, Histiocytic Sarcoma, Metastatic,
Mesentery 1 (100%)
Diaphragm, Thymoma Malignant, Metastatic,
Thymus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (99) (45) (60) (60) (100)
Granular Cell Tumor Malignant 1 (2%)
Meninges, Carcinoma, Metastatic, Zymbal's
Gland 1 (1%)
Spinal Cord (1) (2) (2)
Astrocytoma Malignant 1 (100%)
Page 11
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont
Osteosarcoma, Metastatic, Bone 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (99) (45) (60) (60) (100)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (1%)
Carcinoma, Metastatic, Prostate 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (1%)
Fibrosarcoma, Metastatic, Ear 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
Mediastinum, Histiocytic Sarcoma, Metastatic,
Mesentery 1 (2%)
Mediastinum, Thymoma Malignant, Metastatic,
Thymus 1 (1%)
Nose (99) (45) (60) (60) (100)
Mucosa, Squamous Cell Carcinoma 1 (1%)
Mucosa, Squamous Cell Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (1) (1) (1)
Pinna, Fibroma 1 (100%)
Pinna, Fibrosarcoma 1 (100%)
Pinna, Neurofibrosarcoma 1 (33%) 1 (100%)
Pinna, Squamous Cell Carcinoma 1 (33%)
Zymbal's Gland (3) (1) (2) (1) (3)
Carcinoma 3 (100%) 1 (100%) 1 (50%) 1 (100%) 2 (67%)
Bilateral, Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (98) (45) (60) (60) (100)
Liposarcoma 1 (1%)
Cortex, Myxoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (1%)
Urinary Bladder (98) (44) (60) (58) (100)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(99) *(45) *(70) *(70) *(100)
Histiocytic Sarcoma 3 (4%) 1 (1%) 1 (1%)
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(99) *(45) *(70) *(70) *(100)
Leukemia Monocytic 1 (1%)
Leukemia Mononuclear 57 (58%) 14 (31%) 23 (33%) 21 (30%) 47 (47%)
Mesothelioma Benign 1 (1%) 2 (2%)
Mesothelioma Malignant 3 (7%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05131-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM FLUORIDE Date: 09/17/94
Route: DOSED WATER Time: 03:55:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 80 38 58 56 88
Total Primary Neoplasms 236 86 153 143 249
Total Animals with Benign Neoplasms 77 35 56 54 83
Total Benign Neoplasms 162 59 113 108 177
Total Animals with Malignant Neoplasms 61 22 31 29 63
Total Malignant Neoplasms 74 27 40 35 72
Total Animals with Metastatic Neoplasms 2 3 2 5 7
Total Metastatic Neoplasm 2 7 8 7 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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