TR 393 Rat Pathology Tables
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7681-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|
| 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X|
Congestion | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 3 1 2 2 3 1 1 2|
Vacuolization Cytoplasmic | 2 4 1 1 |
Bile Duct, Hyperplasia | 1 1 3 2 3 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
Fat, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Cytomegaly | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia | |
Mineralization | 3 |
Necrosis | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Dentine, Incisor, Incisor, | |
Necrosis, Multifocal, Multifocal| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|
| 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Necrosis, Focal | 1 1 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1|
Peridontal Tissue, Incisor, | |
Inflammation, Necrotizing | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 4 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 4 2 3 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 1 1 1 2 2 2 2 1 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Congestion | |
Degeneration, Cystic | 3 |
Hyperplasia | 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 1 4 3 |
Pars Distalis, Cyst | X X X|
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 3 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|
| 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
Inflammation, Chronic Active | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 3 3 |
__________________________________________________________________________|
Vagina | |
Exudate | |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid, Nodular | 3 |
Hyperplasia, Reticulum Cell | |
Infiltration Cellular, Lipocyte | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Depletion Lymphoid | 4 3 2 3 4 3 3 2 3 2 4 4 3 3 3 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 2 4 4 3 3 3 3 2 2 2 3 3 4 1 3 3 3|
Mineralization | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 1 |
Mandible, Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|
| 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | |
Thoracic, Vertebra, Osteosclerosis | 1 3 |
Tibia, Fibrous Osteodystrophy | |
Tibia, Osteosclerosis | 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
Myelin, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic Active | 3 3 |
Mucosa, Ulcer | 2 |
Sinus, Foreign Body | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + |
Anterior Chamber, Hemorrhage | |
Lens, Cataract | 3 3 3 3 4 3 |
Retina, Atrophy | 4 4 4 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 2 2 1 1 3 2 2 2 1 2 2 2 1 3 1 3|
Cortex, Cyst | X|
Renal Tubule, Mineralization | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|
| 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X|
Congestion | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic Active | 1 2 2 1 3 2 |
Vacuolization Cytoplasmic | 2 4 3 |
Bile Duct, Hyperplasia | 1 3 4 2 3 2 2 2 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Cytomegaly | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia | |
Mineralization | |
Necrosis | 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Dentine, Incisor, Incisor, | |
Necrosis, Multifocal, Multifocal| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|
| 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Necrosis, Focal | |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Incisor, | |
Inflammation, Necrotizing | 3 |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 1 1 2 1 3 2 1 1 1 2 1 3 1 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | |
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 |
Bilateral, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 2 2 3 3 3 3 4 4 2 4|
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 3 2 2|
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
Rathke's Cleft, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|
| 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 2 |
Inflammation, Chronic Active | 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 |
__________________________________________________________________________|
Vagina | + + |
Exudate | |
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid, Nodular | |
Hyperplasia, Reticulum Cell | 2 |
Infiltration Cellular, Lipocyte | |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + M + + M + M +|
Depletion Lymphoid | 3 3 3 3 3 1 2 2 2 3 3 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 4 4 3 4 3 3 4 2 2 3 3 3 3 2 4 4 3 4 2 3 3|
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | |
Mandible, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|
| 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | |
Thoracic, Vertebra, Osteosclerosis | |
Tibia, Fibrous Osteodystrophy | |
Tibia, Osteosclerosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | |
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | |
Myelin, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 3 3|
Mucosa, Ulcer | |
Sinus, Foreign Body | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + |
Anterior Chamber, Hemorrhage | 3 |
Lens, Cataract | 4 3 3 3 |
Retina, Atrophy | 4 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 2 1 3 1 1 2 2 1 1 2 2 1 2 3 3 3 2 2 1|
Cortex, Cyst | |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|
| 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Congestion | 3 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic Active | 2 |
Vacuolization Cytoplasmic | 3 4 |
Bile Duct, Hyperplasia | 2 2 2 1 1|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 2 |
Fat, Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 2 2 1 1 1 3 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Cytomegaly | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia | |
Mineralization | |
Necrosis | 1 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + M + + + + + + + + + + + + I + + + + + +|
Dentine, Dentine, Incisor, Incisor, | |
Necrosis, Multifocal, Multifocal| 1 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|
| 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Necrosis, Focal | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 3 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Incisor, | |
Inflammation, Necrotizing | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 2 2 1 3 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 1 1 1 1 1 1 1 2 2 1 2 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | 4 |
Degeneration, Cystic | 2 3 |
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | 2 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Congestion | 3 3 2 4 3 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 3 2 2 2 2|
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|
| 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
Inflammation, Chronic Active | 2 2 2 2 2 2|
Duct, Cyst | X X X X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 3 2 2|
__________________________________________________________________________|
Vagina | + |
Exudate | X |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid, Nodular | |
Hyperplasia, Reticulum Cell | 3 |
Infiltration Cellular, Lipocyte | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + M M + +|
Depletion Lymphoid | 2 3 4 3 3 2 3 2 2 3 4 2 4 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 4 3 3 3 3 3 3 3 3 2 3 3|
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 3 3|
Mandible, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|
| 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 1 |
Thoracic, Vertebra, Osteosclerosis | 1 3|
Tibia, Fibrous Osteodystrophy | 1 |
Tibia, Osteosclerosis | 2 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage | 3 |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Spinal Cord | |
Myelin, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | 2 |
Mucosa, Inflammation, Acute | 3 |
Mucosa, Inflammation, Chronic Active | 2 1 2 2 3 2 |
Mucosa, Ulcer | 2 |
Sinus, Foreign Body | 3 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + |
Anterior Chamber, Hemorrhage | |
Lens, Cataract | 3 3 3 3 3 3 |
Retina, Atrophy | 4 4 4 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 3 1 1 1 2 3 1 1 1 2 2 1 2 2 1 2 1 1 2 2 4|
Cortex, Cyst | |
Renal Tubule, Mineralization | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4| |
DAY ON TEST | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5| |
| 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X| 55 |
Clear Cell Focus | X X X X X | 13 |
Congestion | | 1 3.0|
Eosinophilic Focus | X X | 4 |
Hepatodiaphragmatic Nodule | X X | 8 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 2 2 1 2 2 2| 23 1.8|
Vacuolization Cytoplasmic | 2 3 | 11 2.6|
Bile Duct, Hyperplasia | 1 2 2 2 2 | 25 2.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic Active | | 1 2.0|
Fat, Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acinus, Atrophy | 2 2 | 21 1.5|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acinus, Cytomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acanthosis | 3 | 4 2.8|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia | 2 | 1 2.0|
Mineralization | | 1 3.0|
Necrosis | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4| |
DAY ON TEST | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5| |
| 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Dentine, Dentine, Incisor, Incisor, | | |
Necrosis, Multifocal, Multifocal| | 1 1.0|
Dentine, Incisor, Necrosis, Focal | 1 | 5 1.0|
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 1 | 54 1.1|
Peridontal Tissue, Incisor, | | |
Inflammation, Necrotizing | | 1 3.0|
Peridontal Tissue, Molar, | | |
Inflammation, Suppurative | 4| 3 3.3|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | | 1 2.5|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 4 3 2 3 | 19 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Degeneration, Chronic | 1 1 2 1 2 2 1 2 3 2 2 1 3 2 2 | 69 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Accessory Adrenal Cortical Nodule | | 1 |
Congestion | | 1 4.0|
Degeneration, Cystic | 2 | 5 2.4|
Hyperplasia | 2 2 | 17 2.0|
Hypertrophy | 2 2 | 3 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 | 7 2.0|
Bilateral, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hemorrhage | | 1 4.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4| |
DAY ON TEST | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5| |
| 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Congestion | 4 3 3 | 21 3.0|
Pars Distalis, Cyst | X X X X X X | 20 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 2 2 3 2 2 3 2 | 21 2.3|
Pars Intermedia, Cyst | | 2 |
Pars Intermedia, Hyperplasia | | 1 2.0|
Rathke's Cleft, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
C-Cell, Hyperplasia | 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 98 |
Hyperplasia, Glandular | | 4 2.0|
Inflammation, Chronic Active | 2 2 1 1 2 | 14 1.9|
Duct, Cyst | X X | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cervix, Cyst | X | 2 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2| 12 2.5|
__________________________________________________________________________|____________|
Vagina | | 3 |
Exudate | | 1 |
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + M +| 99 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Mediastinal, Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Fibrosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4| |
DAY ON TEST | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5| |
| 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid, Nodular | | 1 3.0|
Hyperplasia, Reticulum Cell | | 2 2.5|
Infiltration Cellular, Lipocyte | | 1 3.0|
Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M + + +| 90 |
Depletion Lymphoid | 2 3 3 4 3 3 3 3 3 4 2 3 | 62 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 99 |
Hyperplasia, Cystic | 2 3 2 3 2 3 3 3 3 3 2 3 2 2 4 2 3 2 2| 81 2.8|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Humerus, Osteosclerosis | 3 | 4 2.5|
Mandible, Fibrous Osteodystrophy | | 1 2.0|
Thoracic, Vertebra, Fibrous | | |
Osteodystrophy | | 1 1.0|
Thoracic, Vertebra, Osteosclerosis | 2 | 5 2.0|
Tibia, Fibrous Osteodystrophy | | 1 1.0|
Tibia, Osteosclerosis | 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Compression | X X | 6 |
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Myelin, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4| |
DAY ON TEST | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5| |
| 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Squamous | | 1 2.0|
Mucosa, Inflammation, Acute | | 2 2.5|
Mucosa, Inflammation, Chronic Active | 2 | 12 2.3|
Mucosa, Ulcer | | 2 2.0|
Sinus, Foreign Body | | 6 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | + + + + | 21 |
Anterior Chamber, Hemorrhage | | 1 3.0|
Lens, Cataract | 3 3 3 | 19 3.1|
Retina, Atrophy | 4 4 4 | 19 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Nephropathy, Chronic | 2 3 2 1 3 3 2 1 2 1 2 1 3 1 2 1 2 1 3 2 | 84 1.9|
Cortex, Cyst | | 1 |
Renal Tubule, Mineralization | 2 2 1 | 9 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|
DAY ON TEST | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|
| 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPECIAL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 2 3 2 3 2 |
Vacuolization Cytoplasmic | 4 4 3 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 4 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 1 1 1 3 2 2 1 1 1 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|
DAY ON TEST | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|
| 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPECIAL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
Renal, Angiectasis | 2 |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + I + + + + + + + +|
Depletion Lymphoid | 2 2 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 4 2 2 2 3 2 3 3 3 1 3 3 3|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|
DAY ON TEST | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|
| 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPECIAL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Humerus, Osteosclerosis | 2 3 1 |
Maxilla, Fibrous Osteodystrophy | 1 |
Thoracic, Vertebra, Osteosclerosis | 3 |
Tibia, Osteosclerosis | 1 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | 2|
Mucosa, Inflammation, Chronic Active | 2 |
Sinus, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 3 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 3 2 2 2 2 2 2 1 2 2 1 1 1 1|
Cortex, Cyst | X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7| |
DAY ON TEST | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3| |
| 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
SPECIAL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + + + + + | 31 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 32 |
Basophilic Focus | X X X X X X X | 13 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic Active | 2 1 2 2 2 | 11 2.0|
Vacuolization Cytoplasmic | 4 4 3 | 6 3.7|
Bile Duct, Hyperplasia | 1 2 3 1 | 12 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 32 |
Acinus, Atrophy | 2 | 6 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 32 |
Acanthosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 32 |
Necrosis | 2 2 | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + I | 31 |
Dentine, Incisor, Dysplasia | 1 | 2 1.0|
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 1 | 16 1.0|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 3 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 32 |
Degeneration, Chronic | 1 1 1 1 1 2 2 3 | 18 1.4|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7| |
DAY ON TEST | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3| |
| 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
SPECIAL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 32 |
Hyperplasia | 2 | 2 2.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 32 |
Pars Distalis, Congestion | 2 | 1 2.0|
Pars Distalis, Cyst | X X X | 6 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 32 |
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + | 32 |
Hyperplasia, Glandular | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 32 |
Follicle, Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 32 |
Cervix, Cyst | | 1 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 32 |
Mediastinal, Angiectasis | | 1 3.0|
Renal, Angiectasis | | 1 2.0|
Renal, Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7| |
DAY ON TEST | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3| |
| 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
SPECIAL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 32 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + | 29 |
Depletion Lymphoid | 2 3 2 3 2 | 10 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 31 |
Hyperplasia, Cystic | 1 3 3 3 2 3 2 2 3 | 24 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 32 |
Humerus, Osteosclerosis | 3 | 4 2.3|
Maxilla, Fibrous Osteodystrophy | | 1 1.0|
Thoracic, Vertebra, Osteosclerosis | | 1 3.0|
Tibia, Osteosclerosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 32 |
Compression | X | 2 |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 32 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 32 |
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Inflammation, Chronic Active | 2 2 2 | 4 2.0|
Sinus, Foreign Body | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Lens, Cataract | 3 3 3 | 5 3.0|
Retina, Atrophy | 4 4 4 | 5 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7| |
DAY ON TEST | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3| |
| 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
SPECIAL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 32 |
Nephropathy, Chronic | 1 2 1 2 1 2 1 2 2 1 1 | 27 1.6|
Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|
DAY ON TEST | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|
| 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Congestion | |
Eosinophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 2 2 3 2 |
Vacuolization Cytoplasmic | 2 2|
Bile Duct, Hyperplasia | 1 3 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3|
Ulcer | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Necrosis | |
Pigmentation, Hemosiderin | 2 |
Pigmentation | |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 2 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 |
Peridontal Tissue, Incisor, Lower, | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|
DAY ON TEST | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|
| 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 1 2 1 1 1 2 2 2 1 1 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 |
Hypertrophy | 2 |
Necrosis | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 2 3 4 2 3|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Intermedia, Congestion | 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Glandular | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|
DAY ON TEST | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|
| 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 2 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Periovarian Tissue, Cyst | X X X|
Periovarian Tissue, Hemorrhage | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 |
__________________________________________________________________________|
Vagina | + |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Reticulum Cell | 3 |
Capsule, Fibrosis | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 2 3 4 3 2 3 2 4 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 3 2 4 1 2 3 2 3 2 3 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|
DAY ON TEST | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|
| 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Humerus, Osteosclerosis | |
Thoracic, Vertebra, Osteosclerosis | |
Tibia, Osteosclerosis | 1 3 |
Vertebra, Osteosclerosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | 2 2 |
Mucosa, Inflammation, Chronic Active | 3 2 2 |
Sinus, Foreign Body | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 3 3 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Nephropathy, Chronic | 1 2 2 2 1 3 2 3 2 1 2 2 1 3 3 3 1 3 2 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|
| 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Congestion | 2 |
Eosinophilic Focus | X|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 2 1 2 2 2 2 |
Vacuolization Cytoplasmic | 3 3 3 3 |
Bile Duct, Hyperplasia | 2 3 2 2 1 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Necrosis | |
Pigmentation, Hemosiderin | |
Pigmentation | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 2 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Incisor, Lower, | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|
| 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, | |
Suppurative | 3 |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 4 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 1 1 3 2 1 1 1 1 1 1 2 1 1 1 1 2 2 1|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 3 1|
Hypertrophy | 2 2 1 |
Necrosis | 3 |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 3 4 3 |
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Congestion | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|
| 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 1 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Periovarian Tissue, Cyst | X|
Periovarian Tissue, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 2 |
__________________________________________________________________________|
Vagina | |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Reticulum Cell | |
Capsule, Fibrosis | |
Red Pulp, Atrophy | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 2 3 4 3 3 3 3 3 2 2 2 2 3 4 2 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 3 3 4 2 3 3 3 4 2 3 3 3 2 3 3 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|
| 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Humerus, Osteosclerosis | 3 3 1 1 |
Thoracic, Vertebra, Osteosclerosis | 1 3 3 1 2 |
Tibia, Osteosclerosis | 1 2 3 3 2 2 |
Vertebra, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hydrocephalus | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Mucosa, Inflammation, Chronic Active | 3 2 |
Sinus, Foreign Body | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 3 3 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3 |
Nephropathy, Chronic | 3 3 2 2 1 4 3 3 3 2 3 1 1 2 1 2 1 2 3 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7| | |
DAY ON TEST | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3| | |
| 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 60 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X | 38 |
Clear Cell Focus | | 8 |
Congestion | | 1 2.0|
Eosinophilic Focus | | 6 |
Hepatodiaphragmatic Nodule | X X | 8 |
Hyperplasia | | 2 2.5|
Inflammation, Chronic Active | 2 2 2 4 1 | 17 2.0|
Vacuolization Cytoplasmic | 4 4 | 8 3.0|
Bile Duct, Hyperplasia | 2 3 1 3 2 | 14 2.1|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 60 |
Acinus, Atrophy | 3 1 | 10 1.6|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 60 |
Acanthosis | 3 | 3 3.0|
Ulcer | 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 60 |
Erosion | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7| | |
DAY ON TEST | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3| | |
| 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + | 70 |
Dentine, Incisor, Dysplasia | 1 1 1 1 | 8 1.3|
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 | 34 1.1|
Peridontal Tissue, Incisor, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | | 1 3.0|
Peridontal Tissue, Molar, | | |
Inflammation, Suppurative | 3 | 2 2.5|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 2 | 7 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 60 |
Degeneration, Chronic | 1 2 1 3 2 2 2 1 2 2 1 2 2 | 46 1.5|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 1 |
Angiectasis | 3 | 1 3.0|
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 | 13 2.0|
Hypertrophy | 2 | 5 1.8|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 59 |
Angiectasis | 3 | 1 3.0|
Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 60 |
Pars Distalis, Congestion | 3 2 4 4 | 12 3.1|
Pars Distalis, Cyst | X X X X X X | 23 |
Pars Distalis, Hemorrhage | | 2 2.5|
Pars Distalis, Hyperplasia | 3 2 2 2 2 | 13 2.1|
Pars Intermedia, Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7| | |
DAY ON TEST | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3| | |
| 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + | 58 |
Hyperplasia, Glandular | 2 | 7 2.1|
Inflammation, Chronic Active | 2 1 1 | 10 1.5|
Duct, Cyst | X | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Periovarian Tissue, Cyst | X X | 6 |
Periovarian Tissue, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + | 60 |
Cervix, Cyst | X | 1 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 2 1 2 3 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Exudate | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 60 |
Femoral, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 60 |
Mediastinal, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 60 |
Congestion | 3 | 3 2.7|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia, Reticulum Cell | | 1 3.0|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7| | |
DAY ON TEST | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3| | |
| 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Red Pulp, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + | 58 |
Depletion Lymphoid | 3 3 4 2 2 4 4 3 4 3 3 3 | 42 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 3 3 3 3 3 4 3 2 2 3 4 3 4 2 | 51 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 60 |
Ulcer | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Humerus, Fibrous Osteodystrophy | | 1 1.0|
Humerus, Osteosclerosis | 1 | 5 1.8|
Thoracic, Vertebra, Osteosclerosis | 1 1 | 7 1.7|
Tibia, Osteosclerosis | 2 2 2 | 11 2.1|
Vertebra, Osteosclerosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 60 |
Compression | | 4 |
Hydrocephalus | | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Squamous | | 2 2.0|
Mucosa, Inflammation, Chronic Active | 3 2 | 7 2.4|
Sinus, Foreign Body | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7| | |
DAY ON TEST | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3| | |
| 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 10 |
Lens, Cataract | 3 3 2 3 | 10 2.9|
Retina, Atrophy | 4 4 4 4 | 10 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 60 |
Inflammation, Acute, Focal | | 1 3.0|
Nephropathy, Chronic | 2 1 2 1 2 2 3 2 1 2 2 1 3 1 2 | 58 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 59 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|
DAY ON TEST | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|
| 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X |
Congestion | 2 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X X |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia | |
Inflammation, Chronic Active | 2 2 3 1 2 1 2|
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 3 3 2 |
Bile Duct, Hyperplasia | 2 2 2|
Centrilobular, Necrosis | 3 |
Hepatocyte, Degeneration, Cystic | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Congestion, Acute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
Acinus, Cytomegaly, Focal | |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic Active | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Pigmentation, Hemosiderin | |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|
DAY ON TEST | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|
| 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Dysplasia | 1 |
Dentine, Incisor, Necrosis, Focal | |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1|
Incisor, Ameloblast, Degeneration | 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 1 1 2 1 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 2 2 2|
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | |
Bilateral, Degeneration, Cystic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 2 3 4 3 3 3 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 3 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 3 |
Inflammation, Chronic Active | 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|
DAY ON TEST | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|
| 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic | |
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 1 2|
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Femoral, Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Necrosis | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | M + + + + + + + + M + + + + + + + + + +|
Depletion Lymphoid | 2 3 2 2 2 3 2 2 3 3 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 4 3 3 3 4 2 2 3 4 3 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosclerosis | |
Femur, Osteosclerosis | 2 |
Humerus, Osteosclerosis | 2 2 2 |
Joint, Cartilage, Tibia, Degeneration| |
Maxilla, Osteosclerosis | 1 2 |
Thoracic, Vertebra, Osteosclerosis | 2 2 1 |
Tibia, Osteosclerosis | 1 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|
DAY ON TEST | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|
| 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic Active | 2 2 |
Sinus, Foreign Body | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Lens, Cataract | 3 3 3 3|
Retina, Atrophy | 4 4 4 4|
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 1 2 1 3 2 2 2 2 2 1 3 4 2 2 2|
Renal Tubule, Atrophy | |
Renal Tubule, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|
DAY ON TEST | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|
| 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X |
Congestion | |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia | 3 3 3 |
Inflammation, Chronic Active | 2 2 3 2 2 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 3 4 1 |
Bile Duct, Hyperplasia | 2 3 2 1 2 2 3 2 3 |
Centrilobular, Necrosis | |
Hepatocyte, Degeneration, Cystic | |
__________________________________________________________________________|
Mesentery | |
Fat, Congestion, Acute | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 |
Acinus, Cytomegaly, Focal | 2 |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Inflammation, Chronic Active | 3 |
Ulcer | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Necrosis | |
Pigmentation, Hemosiderin | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|
DAY ON TEST | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|
| 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Dysplasia | 1 |
Dentine, Incisor, Necrosis, Focal | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 |
Incisor, Ameloblast, Degeneration | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 2 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Chronic | 1 1 2 1 1 1 2 3 3 2 1 2 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 3 |
Bilateral, Degeneration, Cystic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Congestion | 3 3 4 4 4 3 |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 3 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Glandular | 2 2 |
Inflammation, Chronic Active | 2 2 2 2 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|
DAY ON TEST | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|
| 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Infarct, Chronic | |
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 1 1 2 2 3 |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Femoral, Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Fibrosis | 2 |
Necrosis | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + |
Depletion Lymphoid | 4 2 2 3 3 2 3 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 4 3 3 4 2 2 3 2 3 4 3 3 3 3 3 3 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosclerosis | 4 |
Femur, Osteosclerosis | |
Humerus, Osteosclerosis | 4 |
Joint, Cartilage, Tibia, Degeneration| |
Maxilla, Osteosclerosis | |
Thoracic, Vertebra, Osteosclerosis | 4 1 |
Tibia, Osteosclerosis | 4 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | X X X X |
Hydrocephalus | 3 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|
DAY ON TEST | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|
| 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Metaplasia, Squamous | 2 |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 2 |
Sinus, Foreign Body | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Lens, Cataract | 3 3 3 3 3 |
Retina, Atrophy | 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 3 3 4 2 3 1 1 4 2 3 2 3 3 2 2 3 1 3 3 2 |
Renal Tubule, Atrophy | |
Renal Tubule, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| | |
DAY ON TEST | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3| | |
| 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X | 9 |
Congestion | | 2 2.0|
Eosinophilic Focus | X X X | 7 |
Hepatodiaphragmatic Nodule | X | 10 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia | | 3 3.0|
Inflammation, Chronic Active | 1 3 1 | 16 1.9|
Mixed Cell Focus | X | 1 |
Vacuolization Cytoplasmic | | 7 2.6|
Bile Duct, Hyperplasia | 1 1 3 1 2 2 | 18 2.0|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Degeneration, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Congestion, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 3 2 | 7 2.0|
Acinus, Cytomegaly, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + | 59 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | 3 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 60 |
Necrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| | |
DAY ON TEST | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3| | |
| 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + | 70 |
Dentine, Incisor, Dysplasia | 1 2 | 4 1.3|
Dentine, Incisor, Necrosis, Focal | 1 1 1 | 4 1.0|
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 4 1 1 | 26 1.1|
Incisor, Ameloblast, Degeneration | | 1 2.0|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 2 3 3 | 10 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Chronic | 2 1 1 1 1 3 1 1 2 2 2 1 2 1 | 43 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 2 2 3 2 2 | 18 2.1|
Hypertrophy | 3 2 | 5 2.2|
Vacuolization Cytoplasmic, Focal | | 2 2.5|
Bilateral, Degeneration, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 2 2 | 8 2.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 60 |
Pars Distalis, Congestion | 2 3 3 2 3 | 17 3.1|
Pars Distalis, Cyst | X X X X X X | 17 |
Pars Distalis, Hyperplasia | 3 3 2 | 10 2.6|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 2 2 2 2 2 | 9 2.1|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| | |
DAY ON TEST | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3| | |
| 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Glandular | 3 2 | 6 2.3|
Inflammation, Chronic Active | 2 2 1 3 | 11 1.9|
Duct, Cyst | X | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 60 |
Infarct, Chronic | 3 | 1 3.0|
Cervix, Cyst | X X | 2 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 | 11 1.8|
Lumen, Hemorrhage | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 60 |
Femoral, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 60 |
Depletion Lymphoid | 2 | 1 2.0|
Fibrosis | | 2 2.0|
Necrosis | | 1 3.0|
Red Pulp, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + | 56 |
Depletion Lymphoid | 3 2 2 2 3 2 4 2 2 3 3 3 4 4 4 2 2 | 43 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 2 2 3 3 4 2 2 3 2 2 2 2 3 2 3 3 2 | 52 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Cranium, Osteosclerosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| | |
DAY ON TEST | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3| | |
| 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Femur, Osteosclerosis | | 1 2.0|
Humerus, Osteosclerosis | | 4 2.5|
Joint, Cartilage, Tibia, Degeneration| 1 | 1 1.0|
Maxilla, Osteosclerosis | | 2 1.5|
Thoracic, Vertebra, Osteosclerosis | | 5 2.0|
Tibia, Osteosclerosis | 3 2 | 9 2.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 60 |
Compression | X | 7 |
Hydrocephalus | 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Squamous | | 1 2.0|
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Inflammation, Chronic Active | 2 | 5 2.0|
Sinus, Foreign Body | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 13 |
Lens, Cataract | 3 3 3 3 | 13 3.0|
Retina, Atrophy | 4 4 4 4 | 13 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 60 |
Nephropathy, Chronic | 3 3 3 1 1 3 1 2 2 1 3 3 2 4 1 3 2 | 55 2.2|
Renal Tubule, Atrophy | 4 | 1 4.0|
Renal Tubule, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| | |
DAY ON TEST | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3| | |
| 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|
DAY ON TEST | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|
| 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X|
Hepatodiaphragmatic Nodule, Multiple | |
Inflammation, Chronic Active | 2 1 1 2 2 3 2 1|
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 3 4 1 |
Bile Duct, Hyperplasia | 2 3 4 2 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 2 1 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic Active | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 |
Dentine, Incisor, Necrosis, Focal | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 |
Incisor, Odontoblast, Degeneration | |
Incisor, Ameloblast, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|
DAY ON TEST | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|
| 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 2 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 1 2 2 2 2 1 1 2 1 2 1 2 2 2 2 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | 3 2 |
Hyperplasia | 2 2 2 |
Hypertrophy | 2 1|
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 2 3 3 3 2 3 |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hemorrhage | 3 4 |
Pars Distalis, Hyperplasia | 1 2 2 2 3 2 3 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + M + + + + +|
Hyperplasia, Glandular | 2 2 |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|
DAY ON TEST | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|
| 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Cyst | X |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cervix, Cyst | X X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | 4 |
Thrombosis | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Depletion Lymphoid | 2 3 2 2 4 3 2 2 3 3 3 3 4 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 3 3 1 3 3 1 3 3 2 4 3 3 3 4 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Humerus, Osteosclerosis | 2 4 |
Maxilla, Osteosclerosis | 2 |
Thoracic, Vertebra, Osteosclerosis | 2 3 |
Tibia, Osteosclerosis | 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|
DAY ON TEST | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|
| 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
Hydrocephalus | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 2 3 2 3 3 |
Mucosa, Ulcer | |
Sinus, Foreign Body | 2 2 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Eye | + + + + |
Anterior Chamber, Hemorrhage | |
Cornea, Inflammation, Acute | |
Lens, Cataract | 3 3 3 3 |
Retina, Atrophy | 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 1 2 1 1 1 2 2 1 1 2 3 2 2 3 3 1 2 2 1 1|
Cortex, Infarct, Chronic, Multifocal | 3 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|
DAY ON TEST | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|
| 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Chronic Active | 2 2 2 2 2 |
Mixed Cell Focus | X X |
Vacuolization Cytoplasmic | 4 2 1 2 3 2 2 2 |
Bile Duct, Hyperplasia | 2 2 1 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | 2 3 |
Ulcer | 3 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
Pigmentation, Hemosiderin | |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 2 |
Dentine, Incisor, Necrosis, Focal | 1 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 |
Incisor, Odontoblast, Degeneration | |
Incisor, Ameloblast, Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|
DAY ON TEST | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|
| 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 4 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 1 1 1 2 2 2 1 1 2 1 1 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 |
Hypertrophy | 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 3 4 3 3 |
Pars Distalis, Cyst | X X X X X X X X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 2 2|
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
Hyperplasia | |
Inflammation, Chronic Active | 1 4 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|
DAY ON TEST | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|
| 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Cyst | X X |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | X |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | |
Thrombosis | X |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + + + + + + + + + + M + + +|
Depletion Lymphoid | 3 3 4 2 3 2 3 3 2 2 3 3 3 2 3 3 2 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 4 3 2 2 3 3 2 2 4 2 3 3 2 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Humerus, Osteosclerosis | 3 2 1 |
Maxilla, Osteosclerosis | |
Thoracic, Vertebra, Osteosclerosis | 3 2 1 |
Tibia, Osteosclerosis | 1 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|
DAY ON TEST | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|
| 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 2 |
Hydrocephalus | 3 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic Active | 3 3 2 3 |
Mucosa, Ulcer | 2 |
Sinus, Foreign Body | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Inflammation, Chronic Active | |
__________________________________________________________________________|
Eye | + + + + + + |
Anterior Chamber, Hemorrhage | 3 |
Cornea, Inflammation, Acute | 3 |
Lens, Cataract | 3 3 3 3 3 |
Retina, Atrophy | 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy, Chronic | 2 2 1 2 2 2 1 1 1 2 4 2 2 3 2 1 2 3 |
Cortex, Infarct, Chronic, Multifocal | |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|
DAY ON TEST | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|
| 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Multiple | |
Inflammation, Chronic Active | 2 2 1 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 4 1 4|
Bile Duct, Hyperplasia | 2 2 1 2 3|
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +|
Acinus, Atrophy | 2 1 1 2|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + M + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic Active | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Pigmentation, Hemosiderin | |
Ulcer | 2 3 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 2 1 |
Dentine, Incisor, Necrosis, Focal | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 2 1 1 1 1 1 |
Incisor, Odontoblast, Degeneration | 1 |
Incisor, Ameloblast, Degeneration | 1 2 4 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|
DAY ON TEST | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|
| 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 4 2 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 2 3 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 1 1 1 1 2 1 1 2 2 2 3 2 1 2|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 |
Hypertrophy | 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 3 3 4 3 3|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 |
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|
DAY ON TEST | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|
| 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Cyst | |
Duct, Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cervix, Cyst | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | |
Thrombosis | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + M|
Depletion Lymphoid | 2 2 3 3 3 3 3 3 2 3 3 4 4 4 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 4 3 4 3 2 3 3 2 2 2 2 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 2 |
Humerus, Osteosclerosis | 1 |
Maxilla, Osteosclerosis | |
Thoracic, Vertebra, Osteosclerosis | 2 |
Tibia, Osteosclerosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|
DAY ON TEST | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|
| 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
Hydrocephalus | 2 3 3 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 3 3 2 |
Mucosa, Ulcer | 2 |
Sinus, Foreign Body | 2 3 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Inflammation, Chronic Active | |
__________________________________________________________________________|
Eye | + + + + + + + + |
Anterior Chamber, Hemorrhage | |
Cornea, Inflammation, Acute | |
Lens, Cataract | 3 3 3 3 3 3 4 3 |
Retina, Atrophy | 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 1 2 3 3 3 2 1 3 2 2 2 2 3 2 2 1 2 2 3|
Cortex, Infarct, Chronic, Multifocal | |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Basophilic Focus | X X X X X X X X X X X X X X X | 52 |
Clear Cell Focus | X X X X X X| 8 |
Eosinophilic Focus | X X X X | 9 |
Hepatodiaphragmatic Nodule | X X X X | 15 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Inflammation, Chronic Active | 2 1 2 1 2 2 2| 24 1.8|
Mixed Cell Focus | | 2 |
Vacuolization Cytoplasmic | 3 2 3 | 19 2.5|
Bile Duct, Hyperplasia | 2 4 2 2 3| 23 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Acinus, Atrophy | 3 2 1 1 1 1 2 | 21 1.6|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Acanthosis | 3 | 3 2.7|
Inflammation, Chronic Active | | 2 2.5|
Ulcer | | 6 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Necrosis | | 3 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Dentine, Incisor, Dysplasia | 1 3 2 | 10 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dentine, Incisor, Necrosis, Focal | | 4 1.0|
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 53 1.0|
Incisor, Odontoblast, Degeneration | 1 | 2 1.0|
Incisor, Ameloblast, Degeneration | 4 3 | 7 2.3|
Peridontal Tissue, Molar, | | |
Inflammation, Suppurative | | 4 3.0|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 2 3 3 3 2 2 2 2 | 21 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Degeneration, Chronic | 2 1 3 2 1 1 1 1 2 1 1 1 1 1 1 | 69 1.6|
Inflammation, Chronic Active | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Cystic | 2 | 3 2.3|
Hyperplasia | 2 2 2 2 | 15 2.0|
Hypertrophy | 2 2 2 | 10 1.9|
Vacuolization Cytoplasmic, Focal | | 7 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Cyst | X | 1 |
Hyperplasia | | 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Pars Distalis, Congestion | 3 4 2 3 3 3 3 | 22 3.0|
Pars Distalis, Cyst | X X X X X X X X X| 30 |
Pars Distalis, Hemorrhage | 3 | 5 3.4|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3| 19 2.2|
Pars Intermedia, Cyst | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
C-Cell, Hyperplasia | 2 | 8 2.0|
Follicle, Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hyperplasia, Glandular | 3 2 | 6 2.3|
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 2 3 2 3 2 | 18 1.9|
Duct, Cyst | X X | 5 |
Duct, Hyperplasia, Squamous | 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Bilateral, Periovarian Tissue, Cyst | | 1 |
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hemorrhage | 2 | 1 2.0|
Cervix, Cyst | X X | 4 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 4 3 1 2 2| 13 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Femoral, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Depletion Lymphoid | | 2 2.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Granulomatous | | 1 4.0|
Thrombosis | | 1 |
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 95 |
Depletion Lymphoid | 3 3 3 3 3 3 4 2 2 2 2 2 3 3 2 2 3 3 4 3 3 2| 73 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 99 |
Hyperplasia, Cystic | 2 3 4 3 4 3 2 2 3 4 3 3 2 3 2 2 3 2 2 3 2 2| 77 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Femur, Fibrous Osteodystrophy | | 1 2.0|
Humerus, Osteosclerosis | 2 1 2 2 2 | 11 2.0|
Maxilla, Osteosclerosis | 1 2 | 3 1.7|
Thoracic, Vertebra, Osteosclerosis | 1 2 2 1 2 2 1 1 2 | 15 1.8|
Tibia, Osteosclerosis | 1 2 3 2 2 3 1 3 1| 15 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Compression | X | 10 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 6 2.7|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Alveolar Epithelium, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Inflammation, Chronic Active | | 1 2.0|
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Inflammation, Chronic Active | 3 4 2 3 | 18 2.7|
Mucosa, Ulcer | | 2 2.0|
Sinus, Foreign Body | 2 3 3 | 15 2.4|
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +| 98 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Pinna, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + + | 26 |
Anterior Chamber, Hemorrhage | | 1 3.0|
Cornea, Inflammation, Acute | | 1 3.0|
Lens, Cataract | 3 3 3 3 3 3 3 3 | 25 3.0|
Retina, Atrophy | 4 4 4 4 4 4 4 4 | 25 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
175 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic | 1 3 3 2 2 2 2 1 2 3 2 2 1 3 2 3 1 1 2 3 1 2 1| 82 1.9|
Cortex, Infarct, Chronic, Multifocal | | 1 3.0|
Renal Tubule, Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 100 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|
DAY ON TEST | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|
| 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 1 1 |
Vacuolization Cytoplasmic | 3 2 3 2 |
Bile Duct, Hyperplasia | 3 4 2 2 2 2 2 2 3 3 2 2 2 2 4 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Hepatocyte, Degeneration, Cystic | 4 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 2 2 3 2 2 |
Acinus, Hyperplasia | 2 |
Artery, Inflammation, Chronic Active | 3 |
Vein, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Mineralization | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + +|
Dysplasia | 2 |
Hyperplasia | |
Mineralization | |
Necrosis | |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|
DAY ON TEST | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|
| 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 1 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Peridontal Tissue, Molar, | |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 4 4 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 3 2 2 2 3 3 2 2 2 3 2 2 2 3 2 2 2 1 2 2 1|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hemorrhage | |
Hyperplasia | 3 2 3 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hemorrhage | 3 3 3 |
Pars Distalis, Hyperplasia | 3 3 3 2 2 3 |
Pars Distalis, Inflammation, Chronic | |
Active | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|
DAY ON TEST | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|
| 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 3 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + +|
Dilatation | 4 3 |
Inflammation, Chronic Active | 3 3 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 3 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 1 3 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + M + + A + + M + + + + + + + + + + +|
Depletion Lymphoid | 4 3 3 2 2 3 2 2 3 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + M + M + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 2 1 2 2 3 2 2 3 2 2 2 2 2 2 3 3 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|
DAY ON TEST | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|
| 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | 1 |
Humerus, Osteosclerosis | |
Humerus, Joint, Cartilage, | |
Degeneration, Focal | |
Humerus, Joint, Cartilage, | |
Degeneration | |
Humerus, Joint, Cartilage, Necrosis, | |
Focal | 3 |
Humerus, Ligament, Metaplasia, | |
Cartilagenous, Focal | |
Joint, Cartilage, Tibia, Necrosis, | |
Focal | |
Mandible, Fibrous Osteodystrophy | |
Maxilla, Fibrous Osteodystrophy | 3 |
Thoracic, Periosteum, Vertebra, | |
Hyperostosis | 3 |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 1 |
Thoracic, Vertebra, Intervertebral | |
Disc, Degeneration | 3 |
Tibia, Fibrous Osteodystrophy | 1 3 |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Degeneration | |
Hydrocephalus | 2 |
Necrosis, Subacute | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|
DAY ON TEST | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|
| 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic Active | 3 3 2 2 3 3 2 |
Mucosa, Ulcer | 2 |
Sinus, Foreign Body | 3 3 2 2 3 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Acanthosis | |
__________________________________________________________________________|
Eye | + + + + + + + |
Lens, Cataract | 4 3 3 3 2 3 3 |
Retina, Atrophy | 4 4 4 4 3 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 2 3 3 3 4 4 2 4 3 4 4 3 3 4 1 3 1 4 4 1|
Cortex, Cyst | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|
| 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 1 2 |
Vacuolization Cytoplasmic | 3 3 1 2 3 4 2 |
Bile Duct, Hyperplasia | 3 2 3 2 3 3 2 3 4 3 2 2 3 3 2 4 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Hepatocyte, Degeneration, Cystic | 2 3 2|
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 2 3 1 1 3 2 |
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic Active | 3 3 |
Vein, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 |
Mineralization | 4 |
Ulcer | 3 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Hyperplasia | |
Mineralization | 3 3 |
Necrosis | 3 2 |
Ulcer | 3 3 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|
| 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | 2 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Molar, | |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | 4 |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 4 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 1 2 3 2 3 2 2 2 2 1 1 1 3 1 3 3 1 3 2 2 3|
Mineralization | 3 |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hemorrhage | |
Hyperplasia | 2 2 2 2|
Vacuolization Cytoplasmic, Focal | 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 2 3 2 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 3 |
Pars Distalis, Inflammation, Chronic | |
Active | 4 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|
| 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 2|
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic Active | 2 2 1 1 1 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 3 2 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 3 2 2 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M M + + M + + +|
Depletion Lymphoid | 3 3 2 3 2 3 2 2 2 2 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 3 2 2 2 1 2 1 2 3 3 2 2 2 4 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|
| 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | 2 3 |
Humerus, Osteosclerosis | 3 2 |
Humerus, Joint, Cartilage, | |
Degeneration, Focal | |
Humerus, Joint, Cartilage, | |
Degeneration | 3 |
Humerus, Joint, Cartilage, Necrosis, | |
Focal | |
Humerus, Ligament, Metaplasia, | |
Cartilagenous, Focal | 2 |
Joint, Cartilage, Tibia, Necrosis, | |
Focal | 4 |
Mandible, Fibrous Osteodystrophy | |
Maxilla, Fibrous Osteodystrophy | 3 |
Thoracic, Periosteum, Vertebra, | |
Hyperostosis | |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 2 |
Thoracic, Vertebra, Intervertebral | |
Disc, Degeneration | |
Tibia, Fibrous Osteodystrophy | 2 3 |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration | 2 |
Hydrocephalus | 2 |
Necrosis, Subacute | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|
| 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic Active | 3 3 1 2 2 2 |
Mucosa, Ulcer | |
Sinus, Foreign Body | 3 3 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Acanthosis | |
__________________________________________________________________________|
Eye | + + + + + + |
Lens, Cataract | 3 3 3 3 3 |
Retina, Atrophy | 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | M |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 4 3 4 2 3 4 4 1 4 4 1 4 1 4 2 4 4 1 2 3 2 2 4|
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|
| 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X X X|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 3 |
Inflammation, Chronic Active | 1 2 2 |
Vacuolization Cytoplasmic | 1 2 4 2 4 3 2 2 2 4 4 |
Bile Duct, Hyperplasia | 1 2 3 2 2 2 2 2 4 2 2 3 2 3 2 2 3 2 2 3 2|
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
Hepatocyte, Degeneration, Cystic | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | 3 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 2 3 3 |
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic Active | 2 |
Vein, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Hyperplasia | 2 |
Mineralization | 3 |
Necrosis | 2 |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|
| 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Dysplasia | |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1|
Peridontal Tissue, Molar, | |
Inflammation, Chronic, | |
Suppurative | |
Peridontal Tissue, Molar, | |
Inflammation, Suppurative | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 2 2 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 2 3 3 3 2 2 3 3 1 3 2 2 2 3 2 3 2 2 2 3 2|
Mineralization | |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hemorrhage | 3 |
Hyperplasia | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 2 3 2 2 1 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 3 3|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Distalis, Inflammation, Chronic | |
Active | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|
| 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 1 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 3 2 2 2 2 2 3 3 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic Active | 1 2 2 2 3 2 2 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 1 |
Seminiferous Tubule, Atrophy | 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | 2 2 2|
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + M|
Depletion Lymphoid | 2 3 3 3 3 3 4 3 2 2 3 3 3 3 3 2 4 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 3 3 2 3 2 3 2 2 2 3 3 3 3 2 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|
| 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | 1 |
Humerus, Osteosclerosis | 1 |
Humerus, Joint, Cartilage, | |
Degeneration, Focal | |
Humerus, Joint, Cartilage, | |
Degeneration | |
Humerus, Joint, Cartilage, Necrosis, | |
Focal | |
Humerus, Ligament, Metaplasia, | |
Cartilagenous, Focal | |
Joint, Cartilage, Tibia, Necrosis, | |
Focal | |
Mandible, Fibrous Osteodystrophy | |
Maxilla, Fibrous Osteodystrophy | 1 |
Thoracic, Periosteum, Vertebra, | |
Hyperostosis | |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 1 |
Thoracic, Vertebra, Intervertebral | |
Disc, Degeneration | |
Tibia, Fibrous Osteodystrophy | 1 1 |
Tibia, Osteosclerosis | 2 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration | |
Hydrocephalus | |
Necrosis, Subacute | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|
| 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic Active | 3 3 3 4 2 3|
Mucosa, Ulcer | |
Sinus, Foreign Body | 3 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Acanthosis | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 3 3 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 4 2 3 3 3 3 2 4 2 3 4 3 1 4 2 4 2 2 3 4 3 2 4|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Basophilic Focus | X X X X X | 18 |
Clear Cell Focus | X X X X X | 23 |
Eosinophilic Focus | X X | 5 |
Hepatodiaphragmatic Nodule | | 7 |
Hyperplasia | | 4 3.0|
Inflammation, Chronic Active | 1 2 1 1| 13 1.4|
Vacuolization Cytoplasmic | 2 3 2 2 2 3 3 3 3 2| 32 2.6|
Bile Duct, Hyperplasia | 3 3 4 2 4 2 3 4 2 3 2 2 3 3 2 2 3 2 3 2| 73 2.5|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Hepatocyte, Degeneration, Cystic | 2 2 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Mesentery | + + + | 13 |
Fat, Inflammation, Chronic Active | 4 3 3 | 12 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Acinus, Atrophy | 2 3 2 1 2 2 2 1 2 2 4| 34 2.2|
Acinus, Hyperplasia | | 1 2.0|
Artery, Inflammation, Chronic Active | 3 | 5 2.8|
Vein, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Acanthosis | 3 3 3 3 | 9 2.8|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 3 | 3 3.0|
Mineralization | | 1 4.0|
Ulcer | 3 | 8 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia | 2 | 2 2.0|
Hyperplasia | | 1 2.0|
Mineralization | | 3 3.0|
Necrosis | 2 | 4 2.3|
Ulcer | 2 | 7 2.6|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Dentine, Incisor, Dysplasia | 1 | 4 1.3|
Dentine, Incisor, Necrosis, | | |
Multifocal | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 75 1.1|
Peridontal Tissue, Molar, | | |
Inflammation, Chronic, | | |
Suppurative | 3 | 1 3.0|
Peridontal Tissue, Molar, | | |
Inflammation, Suppurative | 4 | 4 4.0|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 2 2 4 3 2 3 3 4 3 3 3 3 | 27 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Degeneration, Chronic | 2 2 1 2 2 3 2 3 2 2 2 2 2 3 3 3 2 2 3 2 2 2 3| 91 2.2|
Mineralization | 3 | 2 3.0|
Thrombosis | X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Accessory Adrenal Cortical Nodule | | 1 |
Hemorrhage | | 1 3.0|
Hyperplasia | 2 | 10 2.2|
Vacuolization Cytoplasmic, Focal | 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 1 2 2 2 2 2 2 2 2 1 | 33 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 96 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Pars Distalis, Congestion | | 2 3.0|
Pars Distalis, Cyst | X | 6 |
Pars Distalis, Hemorrhage | | 3 3.0|
Pars Distalis, Hyperplasia | 2 1 2 2| 17 2.2|
Pars Distalis, Inflammation, Chronic | | |
Active | | 1 4.0|
Pars Intermedia, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
C-Cell, Hyperplasia | 2 2 | 5 1.8|
Follicle, Cyst | X X | 2 |
Follicular Cell, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 2 1 2 2 2 2| 54 2.1|
Duct, Cyst | X | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Dilatation | | 4 3.3|
Inflammation, Chronic Active | 2 3 1 2 2 1 2 | 29 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
Atrophy | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2| 39 1.9|
Seminiferous Tubule, Atrophy | 3 3 2 2 2 3 3 | 20 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Femoral, Myelofibrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 97 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Depletion Lymphoid | | 1 3.0|
Fibrosis | 2 | 10 2.2|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + M + M + + + + + + + + + + + + + + +| 88 |
Depletion Lymphoid | 3 4 3 3 3 2 4 3 4 3 3 3 | 54 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + M| 92 |
Hyperplasia, Cystic | 2 2 3 3 2 2 2 3 3 3 2 2 2 3 2 2 2 2 4 2 3 2 2 | 87 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Acanthosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Humerus, Fibrous Osteodystrophy | 3 1 1 3 | 8 1.9|
Humerus, Osteosclerosis | 1 | 4 1.8|
Humerus, Joint, Cartilage, | | |
Degeneration, Focal | 3 | 1 3.0|
Humerus, Joint, Cartilage, | | |
Degeneration | | 1 3.0|
Humerus, Joint, Cartilage, Necrosis, | | |
Focal | | 1 3.0|
Humerus, Ligament, Metaplasia, | | |
Cartilagenous, Focal | | 1 2.0|
Joint, Cartilage, Tibia, Necrosis, | | |
Focal | | 1 4.0|
Mandible, Fibrous Osteodystrophy | 3 | 1 3.0|
Maxilla, Fibrous Osteodystrophy | 2 1 2 2 | 7 2.0|
Thoracic, Periosteum, Vertebra, | | |
Hyperostosis | | 1 3.0|
Thoracic, Vertebra, Fibrous | | |
Osteodystrophy | 1 1 1 2 | 7 1.3|
Thoracic, Vertebra, Intervertebral | | |
Disc, Degeneration | | 1 3.0|
Tibia, Fibrous Osteodystrophy | 2 1 1 3 | 10 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Tibia, Osteosclerosis | | 2 1.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Compression | X | 2 |
Degeneration | | 1 2.0|
Hydrocephalus | | 2 2.0|
Necrosis, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 99 |
Inflammation, Chronic Active | 2 | 4 2.0|
Metaplasia, Squamous | 2 2 | 4 2.0|
Mucosa, Inflammation, Chronic Active | 3 3 3 2 3 3 | 25 2.6|
Mucosa, Ulcer | | 1 2.0|
Sinus, Foreign Body | 3 2 3 3 3 | 20 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Pinna, Acanthosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + | 23 |
Lens, Cataract | 3 3 3 3 3 3 | 21 3.0|
Retina, Atrophy | 4 4 4 4 2 4 4 | 22 3.9|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Nephropathy, Chronic | 1 4 3 2 4 3 3 3 3 3 2 3 3 2 4 2 2 2 4 3 4 4 4 1 3| 97 3.0|
Cortex, Cyst | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4| |
DAY ON TEST | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5| |
| 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 98 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|
DAY ON TEST | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|
| 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Basophilic Focus | X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 1 |
Vacuolization Cytoplasmic | 2 3 2 2 3 2 2 3 3 2|
Bile Duct, Hyperplasia | 2 4 3 3 1 2 3 1 2 2 2 3 2 2 2 2 1 3 4|
Hepatocyte, Degeneration, Cystic | 2 2|
__________________________________________________________________________|
Mesentery | + +|
Fat, Hemorrhage | |
Fat, Inflammation, Chronic Active | 2 3|
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 4 1 2 2 3 3 1 1 |
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 2 3|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1|
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|
DAY ON TEST | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|
| 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Suppurative | 3 3 3 3 2 4 3 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 3 3 3 3 3 2 3 2 2 3 3 1 2 2 2 3 3|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
Hemorrhage | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 3 2 2 2 1 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 1 2 2 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 2 3 3 3 |
Serosa, Inflammation, Chronic Active | 3|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|
DAY ON TEST | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|
| 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Depletion Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Hyperplasia, Reticulum Cell | |
Capsule, Cyst, Multiple | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 2 2 2 3 3 3 2 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 2 3 3 3 3 3 3 2 1 1 2 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4|
Subcutaneous Tissue, Foreign Body | 4|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Humerus, Fibrous Osteodystrophy | 2 |
Humerus, Osteosclerosis | |
Mandible, Fibrous Osteodystrophy | 2 |
Maxilla, Fibrous Osteodystrophy | 2 |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 3 |
Tibia, Fibrous Osteodystrophy | 3 2 |
Tibia, Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|
DAY ON TEST | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|
| 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
SPECIAL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Sciatic, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 4 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
Mucosa, Inflammation, Acute | 3 3 2 3 2 |
Mucosa, Inflammation, Chronic Active | 2 2 2|
Mucosa, Ulcer | 2 3 |
Sinus, Foreign Body | 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 2 2 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | +|
Hyperplasia | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 3 2 3 2 3 3 4 2 2 1 3 2 3 2 3 1 2 4 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6| |
DAY ON TEST | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9| |
| 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
SPECIAL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Angiectasis | | 2 3.5|
Basophilic Focus | X X | 5 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X X | 6 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Vacuolization Cytoplasmic | 4 2 3 2 2 2 3 2 4 2 3 2 3 3 3 3 1 2| 28 2.5|
Bile Duct, Hyperplasia | 4 2 3 3 3 2 3 3 2 2 2 3 2 2 2 2 2 2| 37 2.4|
Hepatocyte, Degeneration, Cystic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Inflammation, Chronic Active | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Acinus, Atrophy | 2 2 2 1 1 2 1 2| 18 1.9|
Acinus, Hyperplasia | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Acanthosis | 3 | 2 3.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | 3 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Mineralization | 4 | 1 4.0|
Ulcer | 3 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6| |
DAY ON TEST | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9| |
| 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
SPECIAL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Dentine, Incisor, Necrosis, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.1|
Peridontal Tissue, Molar, Lower, | | |
Inflammation, Chronic, | | |
Suppurative | 3 3 4 3 3 4 3 4 4 4 3 3 | 22 3.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Degeneration, Chronic | 2 3 2 2 4 2 3 2 2 2 2 2 2 3 1 3 2 | 35 2.4|
Mineralization | 4 | 1 4.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 2| 3 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 2 2 2 | 11 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 3 | 6 2.3|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
C-Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6| |
DAY ON TEST | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9| |
| 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
SPECIAL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Glandular | | 1 2.0|
Inflammation, Chronic Active | 2 1 2 2 2 2 2 2 2 2 1 3 2 2| 30 1.9|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic Active | 2 1 2 | 11 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 30 2.0|
Seminiferous Tubule, Atrophy | 3 | 5 2.8|
Serosa, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Mediastinal, Depletion Lymphoid | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Depletion Lymphoid | 2 | 1 2.0|
Fibrosis | 3 | 2 2.5|
Hyperplasia, Reticulum Cell | 4 | 1 4.0|
Capsule, Cyst, Multiple | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + M + + + + + + + + + + +| 43 |
Depletion Lymphoid | 3 2 4 3 3 3 2 2 3| 19 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M + + + + + + + + + + + + + + + + + + +| 43 |
Hyperplasia, Cystic | 3 2 2 2 2 2 4 3 2 2 2 2 2 2 3 2 2 1 2| 37 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Foreign Body | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6| |
DAY ON TEST | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9| |
| 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
SPECIAL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Humerus, Fibrous Osteodystrophy | 2 | 2 2.0|
Humerus, Osteosclerosis | 1 | 1 1.0|
Mandible, Fibrous Osteodystrophy | 2 | 2 2.0|
Maxilla, Fibrous Osteodystrophy | 2 | 2 2.0|
Thoracic, Vertebra, Fibrous | | |
Osteodystrophy | | 1 3.0|
Tibia, Fibrous Osteodystrophy | 2 | 3 2.3|
Tibia, Osteosclerosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Compression | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Sciatic, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 3.5|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Metaplasia, Squamous | 2 | 1 2.0|
Mucosa, Inflammation, Acute | 2 2 | 7 2.4|
Mucosa, Inflammation, Chronic Active | 2 2 2 | 6 2.0|
Mucosa, Ulcer | 2 | 3 2.3|
Sinus, Foreign Body | 3 | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 3 2.3|
Retina, Atrophy | | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6| |
DAY ON TEST | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9| |
| 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
SPECIAL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Nephropathy, Chronic | 2 3 2 2 2 2 3 3 3 4 3 2 2 4 4 1 3 2 3 2 2 4 4| 44 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|
| 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, | |
Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Eosinophilic Focus | X X X|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic Active | 1 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 2 3 4 2 2 |
Bile Duct, Hyperplasia | 2 2 1 2 3 2 1 2 2 2 2 4 2 4 4 3 3 3 2|
Hepatocyte, Cytomegaly, Focal | |
Hepatocyte, Degeneration, Cystic | 2 2 2 2 |
Subserosa, Congestion | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | 3 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 2 |
Artery, Inflammation, Chronic Active | 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Mucosa, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|
| 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Dysplasia | 1 1 |
Dentine, Incisor, Necrosis, Focal | |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Incisor, Odontoblast, Degeneration | |
Incisor, Ameloblast, Degeneration | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 3 3 2 3 3 4 3 3 |
Pulp, Incisor, Inflammation, Chronic,| |
Necrotizing | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 2 2 3 3 3 2 3 3 2 2 3 2 3 3 3 3|
Thrombosis | |
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 2 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic, Focal | 3 |
Bilateral, Degeneration, Cystic, | |
Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 1 1 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 3 |
Pars Distalis, Vacuolization | |
Cytoplasmic, Focal | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|
| 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
Duct, Cyst | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic Active | 2 1 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Femoral, Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + +|
Depletion Lymphoid | 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3 4 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M + + + + + + + M + + +|
Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 3 1 2 2 2 2 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Ulcer | |
Sebaceous Gland, Cyst | |
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|
| 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiphysis, Tibia, Cyst | X |
Epiphysis, Tibia, Cyst, Multifocal | |
Humerus, Fibrous Osteodystrophy | 1 |
Humerus, Osteoporosis | |
Humerus, Osteosclerosis | 1 |
Humerus, Joint, Cartilage, Necrosis, | |
Focal | 2 |
Humerus, Epiphysis, Cyst | |
Joint, Cartilage, Tibia, Degeneration| |
Mandible, Fibrous Osteodystrophy | |
Maxilla, Fibrous Osteodystrophy | |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | |
Tibia, Fibrous Osteodystrophy | |
Tibia, Osteoporosis | |
Tibia, Osteosclerosis | |
Tibia, Thrombosis, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 3 3 3 3 2 3 4 |
Sinus, Foreign Body | 2 3 3 3 3 3 3 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cornea, Hyperplasia, Squamous | |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|
| 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
Cyst, Multiple | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 4 4 2 2 4 3 4 4 4 4 4 4 3 4 3 2 3 4 4|
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|
DAY ON TEST | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|
| 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Ulcer | |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active, | |
Granulomatous | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 3 3 |
Inflammation, Chronic Active | 2 2 1 2 |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 4 2 4 3 3 2 2 |
Bile Duct, Hyperplasia | 3 3 2 4 2 2 3 4 2 2 2 3 3 3 2 |
Hepatocyte, Cytomegaly, Focal | |
Hepatocyte, Degeneration, Cystic | 2 2 |
Subserosa, Congestion | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 1 2 1 |
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
Mucosa, Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|
DAY ON TEST | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|
| 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dentine, Incisor, Dysplasia | 1 1 |
Dentine, Incisor, Necrosis, Focal | 1 |
Dentine, Incisor, Necrosis, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 |
Incisor, Odontoblast, Degeneration | |
Incisor, Ameloblast, Degeneration | |
Peridontal Tissue, Molar, Lower, | |
Inflammation, Chronic, | |
Suppurative | 2 4 3 2 3 3 2 3 |
Pulp, Incisor, Inflammation, Chronic,| |
Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Chronic | 3 2 2 2 3 2 3 2 3 3 2 3 2 3 2 2 3 3 1 |
Thrombosis | X X |
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
Capsule, Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | 2 |
Bilateral, Degeneration, Cystic, | |
Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 3 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + |
Pars Distalis, Congestion | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 3 2 3 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic, Focal | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|
DAY ON TEST | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|
| 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Glandular | |
Hyperplasia | |
Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 2 1 1 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | |
Inflammation, Chronic Active | 2 3 2 2 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Femoral, Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + |
Depletion Lymphoid | 3 3 3 4 3 3 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 3 1 3 2 2 3 2 2 2 3 2 2 2 1 2 4 2 2 2 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | |
Ulcer | 3 |
Sebaceous Gland, Cyst | |
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|
DAY ON TEST | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|
| 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiphysis, Tibia, Cyst | |
Epiphysis, Tibia, Cyst, Multifocal | |
Humerus, Fibrous Osteodystrophy | 3 3 |
Humerus, Osteoporosis | |
Humerus, Osteosclerosis | |
Humerus, Joint, Cartilage, Necrosis, | |
Focal | |
Humerus, Epiphysis, Cyst | |
Joint, Cartilage, Tibia, Degeneration| 1 |
Mandible, Fibrous Osteodystrophy | 3 |
Maxilla, Fibrous Osteodystrophy | 3 3 |
Thoracic, Vertebra, Fibrous | |
Osteodystrophy | 2 1 |
Tibia, Fibrous Osteodystrophy | 3 3 |
Tibia, Osteoporosis | |
Tibia, Osteosclerosis | |
Tibia, Thrombosis, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | X |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 1 2 3 |
Sinus, Foreign Body | 1 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cornea, Hyperplasia, Squamous | 2 |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | 2 3 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
_____________________________________________________________________________________________________________________
| 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|
DAY ON TEST | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|
| 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 4 3 2 3 3 2 4 2 3 3 3 3 2 4 4 2 4 2 3 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05131-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM FLUORIDE Date: 04/29/97
Route: DOSED WATER Time: 18:55:37
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 4| 4| 1| 6| 7| 7| 1| 6| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 6| 3| 6| 2| 1| 2| 6| 5| 8| 2| 3| 3| 8| 7| 3| 9| 2| 2| 3| 3| | |
| 0| 2| 0| 4| 7| 9| 0| 9| 5| 3| 3| 3| 4| 3| 3| 9| 7| 9| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 60 |
Ulcer | | 1 3.0|
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active, | | |
Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X | 23 |
Clear Cell Focus | X X X X X X X X | 19 |
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | X | 5 |
Hyperplasia | | 3 2.7|
Inflammation, Chronic Active | 1 1 2 2 2 | 11 1.6|
Mixed Cell Focus | X X | 3 |
Vacuolization Cytoplasmic | 2 2 4 2 2 2 3 2 2 2 2 3 | 25 2.5|
Bile Duct, Hyperplasia | 2 2 2 3 3 3 2 2 2 2 3 2 3 4 | 48 2.5|
Hepatocyte, Cytomegaly, Focal | 2 | 1 2.0|
Hepatocyte, Degeneration, Cystic | 2 2 | 8 2.0|
Subserosa, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Fat, Inflammation, Chronic Active | 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 59 |
Acinus, Atrophy | 1 2 2 2 1 2 3 2 | 18 1.8|
Artery, Inflammation, Chronic Active | 3 | 5 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + M + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | 3 | 3 3.0|
Ulcer | 3 2 3 2 | 8 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Necrosis | 2