TR 393 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/17/94
EXP: 05131 SODIUM FLUORIDE TIME: 04:25:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 55221B
CONT: N01-ES-55102 CAS: 7681-49-4
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/17/94
EXP: 05131 SODIUM FLUORIDE TIME: 04:25:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 55221B
CONT: N01-ES-55102 CAS: 7681-49-4
PATHOLOGIST: R. PERSING S. EUSTIS
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 38 CENSORED DEATHS 19 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 59 145 325 417 441 533 543 543 543 549 |
| 570 570 571 599 613 644 645 646 648 656 |
| 665 669 676 677 684 686 690 692 694 697 |
| 712 716 718 718 718 719 719 726 |
| CENSORED DEATHS |
| 184 184 184 184 184 185 185 185 185 185 |
| 459 459 459 459 459 459 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = SPECIAL CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 27 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 180 317 389 414 537 537 555 607 613 614 |
| 620 627 634 645 670 680 695 716 |
| CENSORED DEATHS |
| 282 382 388 404 422 441 464 501 522 526 |
| 533 544 561 570 575 584 591 602 641 644 |
| 655 660 677 691 705 710 726 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 26 CENSORED DEATHS 19 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 422 424 533 584 607 623 634 638 647 654 |
| 663 668 669 670 671 673 676 691 697 699 |
| 706 710 711 717 718 727 |
| CENSORED DEATHS |
| 184 184 184 184 184 185 185 185 185 185 |
| 459 459 459 459 459 459 460 460 460 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 26 CENSORED DEATHS 21 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 382 404 570 575 583 591 603 607 607 619 |
| 642 648 660 668 681 681 684 693 698 702 |
| 715 715 716 717 718 718 |
| CENSORED DEATHS |
| 184 184 185 185 185 185 185 185 185 185 |
| 185 459 459 460 460 460 460 460 460 460 |
| 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 PPM |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 38 CENSORED DEATHS 20 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 282 388 389 464 501 522 526 544 561 570 |
| 587 602 607 614 620 628 645 646 646 655 |
| 659 661 661 664 671 678 681 681 683 683 |
| 687 695 710 711 718 718 726 726 |
| CENSORED DEATHS |
| 184 184 184 184 184 184 184 184 185 190 |
| 459 459 459 459 459 460 460 460 460 460 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 99.0 98.0 98.0 96.9 95.7 94.6 89.6 83.2 74.4 53.0 |
| | |
| | |
|SPECIAL | 100.0 98.0 98.0 96.0 91.6 91.6 86.4 83.7 59.9 39.3 |
|CONTROL | |
| | |
|25 PPM | 100.0 100.0 100.0 100.0 96.7 96.7 94.7 92.7 78.9 49.3 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 96.6 96.6 96.6 86.3 74.0 47.3 |
| | |
| | |
|175 PPM | 100.0 100.0 100.0 98.9 96.7 95.4 90.4 85.4 70.3 52.7 |
| | |
| | |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 53.0% 39.3% 49.3% 47.3% 52.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.680N ----- P=0.923 P=0.746 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 600.9 558.3 647.4 638.3 616.1 |
|NATURAL DEATHS (C) | (24.5) (34.0) (15.6) (17.2) (16.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 600.3 573.9 586.2 571.4 604.7 |
|(STANDARD ERROR) | (18.9) (18.5) (22.9) (23.4) (17.5) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 21 CENSORED DEATHS 20 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 260 376 400 463 509 620 630 634 643 646 |
| 647 663 674 677 682 683 683 691 710 719 |
| 719 |
| CENSORED DEATHS |
| 184 184 184 184 184 184 184 185 185 185 |
| 459 459 459 459 459 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = SPECIAL CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 21 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 320 379 402 599 609 620 632 633 646 670 |
| 716 |
| CENSORED DEATHS |
| 338 415 451 463 515 557 561 568 579 584 |
| 614 628 641 643 643 661 677 698 705 710 |
| 726 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 19 CENSORED DEATHS 20 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 451 565 582 618 620 631 639 659 677 677 |
| 696 702 704 709 715 718 719 719 719 |
| CENSORED DEATHS |
| 184 184 184 184 185 185 185 185 185 185 |
| 459 459 459 459 459 459 460 460 460 460 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 16 CENSORED DEATHS 20 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 568 568 571 575 643 646 647 647 647 662 |
| 663 670 708 715 716 716 |
| CENSORED DEATHS |
| 184 184 184 184 184 185 185 185 185 185 |
| 459 459 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 PPM |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 27 CENSORED DEATHS 19 TERMINAL 54 |
| |
| UNCENSORED DEATHS |
| 338 415 515 557 561 571 578 613 628 631 |
| 631 639 646 647 647 647 678 705 709 714 |
| 716 716 716 719 719 719 722 |
| CENSORED DEATHS |
| 184 184 184 184 185 185 185 185 185 185 |
| 459 459 459 459 459 459 460 460 460 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.9 98.9 96.7 95.4 94.2 94.2 85.4 74.1 |
| | |
| | |
|SPECIAL | 100.0 100.0 100.0 98.0 93.9 93.9 93.9 91.4 77.8 71.0 |
|CONTROL | |
| | |
|25 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 98.3 94.3 84.3 62.2 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.0 78.0 68.0 |
| | |
| | |
|175 PPM | 100.0 100.0 100.0 98.9 97.8 97.8 96.5 91.6 80.5 66.8 |
| | |
| | |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.1% 71.0% 62.2% 68.0% 66.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.681 ----- P=0.285 P=0.630 P=0.442 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 606.1 566.0 658.9 647.6 633.2 |
|NATURAL DEATHS (C) | (27.8) (40.1) (16.1) (13.3) (18.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 621.8 634.5 593.7 594.2 624.4 |
|(STANDARD ERROR) | (17.9) (16.3) (23.2) (23.0) (17.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM FLUORIDE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
SPECIAL CONTROL = 2
25 PPM = 3
100 PPM = 4
175 PPM = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 1 2 5 45 3
| 1 2 21 45 4 13 5 3 4
| 2 2 1 1 5 5 5 1 443
| 2 5511 43 3
P 90 + 11 55 4 4 3 3 3
E | 2 12 1 5 454 33
R | 1 155 33
C | 2 12145 133
E 80 + 2245 113 33
N | 411
T | 41 11
| 22 114
S 70 + 22 5311
U | 22 311
R | 411
V | 2 2 541411
I 60 + 2 2 3334
V | 55
A | 2 2 311
L | 31 1
50 + 2 2 3 3
| 4 4
| 2 2
|
40 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 68 obs hidden.
SODIUM FLUORIDE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
SPECIAL CONTROL = 2
25 PPM = 3
100 PPM = 4
175 PPM = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 5 3 4
| 1 5 1 5 3 3
| 2 1 2 1 5 5
| 2 1 1 5 53 3
95 + 1 1 55
| 2 1 5443 2 1
| 54 11 4
| 5 225 11
P 90 + 535114
E | 2 25311
R |
C | 2 231 1
E 85 + 55 1 1
N | 3 3
T | 4 4 11
| 2 2
S 80 + 5 3 3
U | 51133
R | 2 42 1 51
V | 4 11
I 75 + 2 52
V | 331 1
A | 33
L | 2 2
70 +
|
| 45 4
| 5 5
65 +
|
| 3 3
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.
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