TR 395 Mouse Pathology Tables
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
Facility: TSI Mason Research
Chemical CAS #: 000057669
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + A + + + + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + A|
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + A + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + M + M M + + + M + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + M M + + + M + A + + + + + M + + + + + + + +|
Pars Distalis, Adenoma | |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + M + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + M + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Iliac, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Inguinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + M + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + A M + + + + + + M + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M M M + M M + + + M + + + + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + A M + + + + + + + + + + + M +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + M M + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + M + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + A +| 44 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + M + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Mesentery | +| 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + M + + + + + M + + + + + + + + + +| 45 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Squamous Cell Papilloma | X X X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M A + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M + M + + M M M + + + + + M + + M + M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + M M + M + + + + + + + + + + + + + + + + + + + +| 41 |
Pars Distalis, Adenoma | X | 1 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | M + + M + + + + M + + + + + + + + + + + + + + + M| 43 |
Axillary, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Iliac, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Inguinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 3 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + + + M M + + + + + + + + + + + + + + + M| 41 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + M + + + + + + M + + + M| 42 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M M M M M M + M + M M + + M + M M M + +| 22 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + M + + + + + + + + + + M + + + + + + M M M +| 41 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + A +| 44 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M A + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + +|
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
Histiocytic Sarcoma | |
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + M +|
__________________________________________________________________________|
Intestine Small | + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A +|
Histiocytic Sarcoma | |
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + +|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Luteoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Polyp Stromal | X |
Endometrium, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Axillary, Lymphoma Malignant Mixed | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X |
__________________________________________________________________________|
Thymus | + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M|
__________________________________________________________________________|
Skin | + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + M + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + A +| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + +| 14 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + +| 15 |
Histiocytic Sarcoma | X | 1 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + M + + + M + +| 10 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + A +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + A +| 14 |
Histiocytic Sarcoma | X | 1 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + +| 19 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + +| 14 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + M + + + M + + + + +| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M M + + + + +| 13 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Histiocytic Sarcoma | X | 1 |
Luteoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + +| 30 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Polyp Stromal | | 1 |
Endometrium, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 26 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 3 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 3 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 3 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + +| 20 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 25 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 4 |
__________________________________________________________________________|____________|
Thymus | + + M + + + +| 12 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M| 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + +| 16 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + +| 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 23 |
Alveolar/Bronchiolar Adenoma | | 4 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + +| 19 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + +| 13 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + M A + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Lymphoid Nodule, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + A + + + + + + + + + + A A + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M M + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + M + + + + + + M M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M M + + + M M M M M M M + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + M + + + + + M|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + M + + M + + + + + +|
Axillary, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + + M + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hemangiosarcoma, Metastatic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + M M + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + M + M + M M M + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + M + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | +|
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + A + + + + + + + + + + + + + + + + + + + A| 46 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Lymphoid Nodule, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic | | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X | 4 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + M + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + M +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M M + + + M M + M + M + + + + M + + M + +| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + M + + + + + + + + M M + + M M M| 38 |
Pars Distalis, Adenoma | X X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + M + + + + + + + + A| 45 |
Axillary, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + M + + + A| 44 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma, Metastatic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + + + + + + + + + + M + + M M +| 42 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + + M + + + + M M + + M + + M M| 32 |
__________________________________________________________________________|____________|
Skin | M + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X | 5 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + M + + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X|
Hepatocellular Adenoma | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + M M M M M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + M M M M M M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + M + + M|
Axillary, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Inguinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + M + + M|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + M + M + + + + + M + + + M + + + + + M + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + + M + + + M +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + + + + + + + + + + M + + + + M| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X | 7 |
Hepatocellular Adenoma | X X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A M + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + M + M + + + M + M + + + + M M + + + M +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + M + + + + + + + + + M M M + + + +| 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 |
Axillary, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Inguinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + M + + M + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M + M M M M M M M + M + M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + M + + + + + A + + + + +| 47 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + M + + + + + + M + M + + M + M + + +| 40 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Adenoma | X X | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A M A + + + + A + + + + + + + A M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + M + + + + + + + A +|
Sarcoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + M + + M + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + A + + + + M + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + A + M + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A M A + + + + M + + + + + + + A +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + M + + + + + M M + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M + M + + M + M + + + M M + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Prostate | M + + + + M + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M M + + + + + + + + + + + + + M +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Histiocytic Sarcoma | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Histiocytic Sarcoma | |
Mediastinal, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M M + + + + + + + + + + + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + M M M + + + M A + + + M + + + + + + + + M M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M + M M + M M M M M M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Neurofibroma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Mediastinum, Fibrosarcoma, Early | |
Invasion | X |
__________________________________________________________________________|
Nose | M + + + + + + + + M + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + + + + + + M A + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 43 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 2 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X X X X X X | 12 |
Hepatocellular Adenoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + M + +| 44 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M + + + + M + + + + + + + + + + + M + +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + M + M + + + + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + A + +| 15 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + M + + + + + + + + + + + + + + + + +| 45 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Histiocytic Sarcoma | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Histiocytic Sarcoma | X | 1 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Histiocytic Sarcoma | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + M + M + + + + + + M M + + + + + + +| 42 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + A + + + M M + + + + + + M M M + + + + + +| 36 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M + M M M M M M M M M M + M M M M M M| 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 4 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
Subcutaneous Tissue, Neurofibroma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 3 |
Mediastinum, Fibrosarcoma, Early | | |
Invasion | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + + +| 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +|
Anus, Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + A + + + + + +|
Lymphoid Nodule, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Lymphoma Malignant Lymphocytic | |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + M M + + M + + + + M + M M M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + M + M + + + + + + + M + + + + + M + + + + M +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + M + + + + M + + M + + + + + M + + + + M +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + M + + + M + M + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Neurofibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Meninges, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + M M + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + M +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + M M + A + + + + + + + + + + A + M M A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 |
Anus, Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A + + A + + + + + + + A + M + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + M A + + + + + + + A + M + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + A A + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + A A + + + + + + + A + M + A + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + A A + + + + + + + A + + + + + + +| 43 |
Lymphoid Nodule, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M A + A + A A + + + + M + + A + M + A M + +| 39 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X X X X | 11 |
Hepatocellular Adenoma | X X X X| 7 |
Hepatocellular Adenoma, Multiple | X | 3 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + A A + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + M + + + + + + M + + + + M +| 46 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M M + + M M + + M M + M + + + M + M M +| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + M M + + + + + + M + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + M M + + + + + + + + + + + + + + + +| 42 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + + + M M M + M + + + + + + + + + + + + +| 38 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + M + + + A + + +| 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + M M M M + + + M + + + + + + M + M + M| 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M + M M M M M M M M M M M M M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Fibrosarcoma | | 3 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Neurofibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Meninges, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 2 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X | 7 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | M + + + + + M + + + + + M + + + M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 453521-453521/453521
--multipart-boundary--