TR 395 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 02 TIME: 15:19:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 000057669
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 02 TIME: 15:19:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 000057669
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 02 TIME: 15:19:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 000057669
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PROBENECID
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Skin: Subcutaneous Tissue Fibroma
Neurofibroma or Fibroma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.3% 4.0% 0.0% | 0.0% 0.0% 3.1% |
|TERMINAL (d) | 2/38 (5%) 0/23 (0%) 0/24 (0%) | 0/32 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 731 (T) 717 --- | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268N P=0.662N P=0.344N | P=0.312 (e) P=0.500 |
|INCIDENTAL TUMOR | P=0.204N P=0.463N P=0.344N | P=0.312 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.241N P=0.627N P=0.344N | P=0.312 (e) P=0.500 |
|COCHRAN-ARMITAGE | P=0.195N | P=0.315 |
|FISHER EXACT | P=0.500N P=0.247N | (e) P=0.505 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 0.0% 0.0% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 2/38 (5%) 0/23 (0%) 0/24 (0%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 731 (T) --- --- | --- 694 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291N P=0.354N P=0.344N | P=0.698N P=0.483 (e) |
|INCIDENTAL TUMOR | P=0.291N P=0.354N P=0.344N | P=0.843 P=0.362 (e) |
|LOGISTIC REGRESSION | P=0.291N P=0.354N P=0.344N | P=0.695N P=0.494 (e) |
|COCHRAN-ARMITAGE | P=0.221N | P=0.685N |
|FISHER EXACT | P=0.247N P=0.247N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 10.5% 4.0% 0.0% | 0.0% 2.9% 3.1% |
|TERMINAL (d) | 4/38 (11%) 0/23 (0%) 0/24 (0%) | 0/32 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 731 (T) 717 --- | --- 694 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.352N P=0.135N | P=0.464 P=0.483 P=0.500 |
|INCIDENTAL TUMOR | P=0.080N P=0.209N P=0.135N | P=0.345 P=0.362 P=0.500 |
|LOGISTIC REGRESSION | P=0.089N P=0.309N P=0.135N | P=0.453 P=0.494 P=0.500 |
|COCHRAN-ARMITAGE | P=0.059N | P=0.477 |
|FISHER EXACT | P=0.181N P=0.059N | P=0.500 P=0.505 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) | 0/48 (0%) 0/49 (0%) 1/49 (2%) |
|ADJUSTED (b) | 0.0% 11.0% 2.9% | 0.0% 0.0% 3.1% |
|TERMINAL (d) | 0/38 (0%) 1/23 (4%) 0/24 (0%) | 0/32 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- 645 634 | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.559 P=0.066 P=0.468 | P=0.312 (e) P=0.500 |
|INCIDENTAL TUMOR | P=0.556N P=0.246 P=0.682 | P=0.312 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.618 P=0.084 P=0.506 | P=0.312 (e) P=0.500 |
|COCHRAN-ARMITAGE | P=0.636 | P=0.314 |
|FISHER EXACT | P=0.121 P=0.500 | (e) P=0.505 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 2/50 (4%) 10/50 (20%) | 3/48 (6%) 2/49 (4%) 14/49 (29%) |
|ADJUSTED (b) | 27.6% 7.6% 33.4% | 7.6% 5.5% 41.0% |
|TERMINAL (d) | 7/38 (18%) 0/23 (0%) 6/24 (25%) | 1/32 (3%) 1/32 (3%) 12/32 (38%) |
|FIRST INCIDENCE (DAYS) | 541 659 515 | 612 595 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268 P=0.041N* P=0.442 | P<0.001 ** P=0.535N P=0.003 ** |
|INCIDENTAL TUMOR | P=0.579N P=0.002N** P=0.369N | P<0.001 ** P=0.500N P=0.001 ** |
|LOGISTIC REGRESSION | P=0.427 P=0.008N** P=0.470N | P<0.001 ** P=0.447N P=0.002 ** |
|COCHRAN-ARMITAGE | P=0.474 | P<0.001 ** |
|FISHER EXACT | P=0.004N** P=0.405N | P=0.490N P=0.004 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 12/50 (24%) 11/50 (22%) | 2/48 (4%) 2/49 (4%) 3/49 (6%) |
|ADJUSTED (b) | 16.3% 36.8% 29.3% | 5.3% 5.5% 9.0% |
|TERMINAL (d) | 3/38 (8%) 4/23 (17%) 2/24 (8%) | 0/32 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 522 492 438 | 687 595 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175 P=0.038 * P=0.109 | P=0.405 P=0.661 P=0.483 |
|INCIDENTAL TUMOR | P=0.546N P=0.425 P=0.564 | P=0.224 P=0.604 P=0.202 |
|LOGISTIC REGRESSION | P=0.569 P=0.164 P=0.469 | P=0.395 P=0.683N P=0.146 |
|COCHRAN-ARMITAGE | P=0.294 | P=0.432 |
|FISHER EXACT | P=0.154 P=0.218 | P=0.684N P=0.510 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 12/50 (24%) 19/50 (38%) | 5/48 (10%) 3/49 (6%) 16/49 (33%) |
|ADJUSTED (b) | 33.8% 36.8% 50.1% | 12.5% 8.5% 45.6% |
|TERMINAL (d) | 9/38 (24%) 4/23 (17%) 7/24 (29%) | 1/32 (3%) 2/32 (6%) 13/32 (41%) |
|FIRST INCIDENCE (DAYS) | 522 492 438 | 612 595 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058 P=0.404 P=0.070 | P<0.001 ** P=0.402N P=0.007 ** |
|INCIDENTAL TUMOR | P=0.352 P=0.185N P=0.490 | P<0.001 ** P=0.450N P<0.001 ** |
|LOGISTIC REGRESSION | P=0.323 P=0.283N P=0.474 | P<0.001 ** P=0.329N P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.153 | P<0.001 ** |
|FISHER EXACT | P=0.326N P=0.263 | P=0.346N P=0.007 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 12/50 (24%) 19/50 (38%) | 5/48 (10%) 3/49 (6%) 16/49 (33%) |
|ADJUSTED (b) | 33.8% 36.8% 50.1% | 12.5% 8.5% 45.6% |
|TERMINAL (d) | 9/38 (24%) 4/23 (17%) 7/24 (29%) | 1/32 (3%) 2/32 (6%) 13/32 (41%) |
|FIRST INCIDENCE (DAYS) | 522 492 438 | 612 595 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058 P=0.404 P=0.070 | P<0.001 ** P=0.402N P=0.007 ** |
|INCIDENTAL TUMOR | P=0.352 P=0.185N P=0.490 | P<0.001 ** P=0.450N P<0.001 ** |
|LOGISTIC REGRESSION | P=0.323 P=0.283N P=0.474 | P<0.001 ** P=0.329N P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.153 | P<0.001 ** |
|FISHER EXACT | P=0.326N P=0.263 | P=0.346N P=0.007 ** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 4/50 (8%) 4/50 (8%) | 1/49 (2%) 4/23 (17%) 5/49 (10%) |
|ADJUSTED (b) | 7.9% 15.1% 12.9% | 3.0% 35.0% 15.1% |
|TERMINAL (d) | 3/38 (8%) 2/23 (9%) 1/24 (4%) | 0/32 (0%) 3/9 (33%) 4/32 (13%) |
|FIRST INCIDENCE (DAYS) | 731 (T) 645 620 | 722 595 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332 P=0.269 P=0.319 | P=0.212 P=0.029 * P=0.105 |
|INCIDENTAL TUMOR | P=0.607 P=0.507 P=0.621 | P=0.143 P=0.015 * P=0.036 * |
|LOGISTIC REGRESSION | P=0.441 P=0.347 P=0.444 | P=0.189 P=0.008 ** P=0.081 |
|COCHRAN-ARMITAGE | P=0.497 | P=0.215 |
|FISHER EXACT | P=0.511 P=0.511 | P=0.033 * P=0.102 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 2/50 (4%) | 2/49 (4%) 0/23 (0%) 1/49 (2%) |
|ADJUSTED (b) | 5.1% 0.0% 6.5% | 6.0% 0.0% 3.1% |
|TERMINAL (d) | 1/38 (3%) 0/23 (0%) 1/24 (4%) | 1/32 (3%) 0/9 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 680 --- 568 | 721 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436 P=0.342N P=0.572 | P=0.514N P=0.376N P=0.507N |
|INCIDENTAL TUMOR | P=0.623 P=0.131N P=0.578N | P=0.604N P=0.534N P=0.629N |
|LOGISTIC REGRESSION | P=0.508 P=0.285N P=0.684 | P=0.510N P=0.549N P=0.530N |
|COCHRAN-ARMITAGE | P=0.525 | P=0.509N |
|FISHER EXACT | P=0.242N P=0.684N | P=0.460N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 4/50 (8%) 6/50 (12%) | 3/49 (6%) 4/23 (17%) 6/49 (12%) |
|ADJUSTED (b) | 12.8% 15.1% 18.7% | 8.8% 35.0% 18.1% |
|TERMINAL (d) | 4/38 (11%) 2/23 (9%) 2/24 (8%) | 1/32 (3%) 3/9 (33%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 680 645 568 | 721 595 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244 P=0.502 P=0.281 | P=0.311 P=0.159 P=0.242 |
|INCIDENTAL TUMOR | P=0.565 P=0.433N P=0.587N | P=0.200 P=0.071 P=0.090 |
|LOGISTIC REGRESSION | P=0.362 P=0.616 P=0.447 | P=0.281 P=0.048 * P=0.195 |
|COCHRAN-ARMITAGE | P=0.416 | P=0.318 |
|FISHER EXACT | P=0.487N P=0.514 | P=0.141 P=0.243 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/38 (0%) 0/44 (0%) 0/44 (0%) | 2/41 (5%) 0/13 (0%) 4/38 (11%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.5% 0.0% 13.8% |
|TERMINAL (d) | 0/29 (0%) 0/22 (0%) 0/22 (0%) | 2/31 (6%) 0/3 (0%) 4/29 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.246 P=0.794N P=0.304 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.246 P=0.794N P=0.304 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.246 P=0.794N P=0.304 |
|COCHRAN-ARMITAGE | (e) | P=0.200 |
|FISHER EXACT | (e) (e) | P=0.573N P=0.302 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) | 0/49 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 11.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/23 (0%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 646 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * (e) P=0.066 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.035 * (e) P=0.224 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.026 * (e) P=0.097 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.030 * | (e) |
|FISHER EXACT | (e) P=0.121 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 3/50 (6%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 13.0% 9.8% | 0.0% 0.0% 3.0% |
|TERMINAL (d) | 0/38 (0%) 2/23 (9%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 390 390 515 | --- --- 717 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.320 P=0.114 P=0.231 | P=0.308 (e) P=0.494 |
|INCIDENTAL TUMOR | P=0.287 P=0.251 P=0.357 | P=0.139 (e) P=0.261 |
|LOGISTIC REGRESSION | P=0.417 P=0.246 P=0.340 | P=0.297 (e) P=0.479 |
|COCHRAN-ARMITAGE | P=0.402 | P=0.315 |
|FISHER EXACT | P=0.181 P=0.309 | (e) P=0.505 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibroma or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 4/50 (8%) | 0/49 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.0% 13.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/23 (0%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 635 635 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017 * P=0.462 P=0.032 * | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.090 P=0.443 P=0.164 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.025 * P=0.499 P=0.052 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.028 * | (e) |
|FISHER EXACT | P=0.500 P=0.059 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 7/50 (14%) 6/50 (12%) | 0/49 (0%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 22.0% 18.7% | 0.0% 3.0% 3.0% |
|TERMINAL (d) | 0/38 (0%) 3/23 (13%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 390 390 515 | --- 717 717 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.100 P=0.014 * P=0.031 * | P=0.467 P=0.494 P=0.494 |
|INCIDENTAL TUMOR | P=0.228 P=0.028 * P=0.171 | P=0.206 P=0.362 P=0.261 |
|LOGISTIC REGRESSION | P=0.158 P=0.043 * P=0.064 | P=0.451 P=0.484 P=0.479 |
|COCHRAN-ARMITAGE | P=0.154 | P=0.477 |
|FISHER EXACT | P=0.030 * P=0.056 | P=0.500 P=0.505 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 6/50 (12%) 3/50 (6%) | 0/49 (0%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 19.6% 9.8% | 0.0% 3.0% 3.0% |
|TERMINAL (d) | 0/38 (0%) 3/23 (13%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 390 390 515 | --- 717 717 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.412 P=0.027 * P=0.231 | P=0.467 P=0.494 P=0.494 |
|INCIDENTAL TUMOR | P=0.464 P=0.061 P=0.357 | P=0.206 P=0.362 P=0.261 |
|LOGISTIC REGRESSION | P=0.527 P=0.078 P=0.340 | P=0.451 P=0.484 P=0.479 |
|COCHRAN-ARMITAGE | P=0.513 | P=0.477 |
|FISHER EXACT | P=0.056 P=0.309 | P=0.500 P=0.505 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 3/49 (6%) 3/49 (6%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 4.3% 0.0% | 9.4% 9.4% 6.3% |
|TERMINAL (d) | 0/38 (0%) 1/23 (4%) 0/24 (0%) | 3/32 (9%) 3/32 (9%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 731 (T) --- | 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.743N P=0.400 (e) | P=0.429N P=0.665 P=0.500N |
|INCIDENTAL TUMOR | P=0.743N P=0.400 (e) | P=0.429N P=0.665 P=0.500N |
|LOGISTIC REGRESSION | P=0.743N P=0.400 (e) | P=0.429N P=0.665 P=0.500N |
|COCHRAN-ARMITAGE | P=0.689N | P=0.419N |
|FISHER EXACT | P=0.500 (e) | P=0.661N P=0.490N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 3/49 (6%) 2/49 (4%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 4.3% 0.0% | 9.4% 6.3% 6.3% |
|TERMINAL (d) | 0/38 (0%) 1/23 (4%) 0/24 (0%) | 3/32 (9%) 2/32 (6%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 731 (T) --- | 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.743N P=0.400 (e) | P=0.485N P=0.500N P=0.500N |
|INCIDENTAL TUMOR | P=0.743N P=0.400 (e) | P=0.485N P=0.500N P=0.500N |
|LOGISTIC REGRESSION | P=0.743N P=0.400 (e) | P=0.485N P=0.500N P=0.500N |
|COCHRAN-ARMITAGE | P=0.689N | P=0.475N |
|FISHER EXACT | P=0.500 (e) | P=0.500N P=0.490N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/50 (0%) 0/47 (0%) | 0/48 (0%) 2/48 (4%) 2/48 (4%) |
|ADJUSTED (b) | 2.6% 0.0% 0.0% | 0.0% 5.9% 6.3% |
|TERMINAL (d) | 1/38 (3%) 0/23 (0%) 0/23 (0%) | 0/32 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 731 (T) --- --- | --- 686 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531N P=0.600N P=0.600N | P=0.285 P=0.228 P=0.238 |
|INCIDENTAL TUMOR | P=0.531N P=0.600N P=0.600N | P=0.216 P=0.166 P=0.238 |
|LOGISTIC REGRESSION | P=0.531N P=0.600N P=0.600N | P=0.259 P=0.223 P=0.238 |
|COCHRAN-ARMITAGE | P=0.466N | P=0.292 |
|FISHER EXACT | P=0.490N P=0.505N | P=0.247 P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 2/50 (4%) | 0/49 (0%) 1/49 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 11.0% 6.1% | 0.0% 2.6% 6.3% |
|TERMINAL (d) | 0/38 (0%) 1/23 (4%) 0/24 (0%) | 0/32 (0%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 645 634 | --- 627 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.302 P=0.066 P=0.195 | P=0.186 P=0.485 P=0.238 |
|INCIDENTAL TUMOR | P=0.567 P=0.246 P=0.495 | P=0.201 P=0.567 P=0.238 |
|LOGISTIC REGRESSION | P=0.362 P=0.084 P=0.240 | P=0.186 P=0.511 P=0.238 |
|COCHRAN-ARMITAGE | P=0.377 | P=0.201 |
|FISHER EXACT | P=0.121 P=0.247 | P=0.500 P=0.253 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 3/50 (6%) | 0/49 (0%) 1/49 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 11.0% 10.0% | 0.0% 2.6% 6.3% |
|TERMINAL (d) | 0/38 (0%) 1/23 (4%) 1/24 (4%) | 0/32 (0%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 645 634 | --- 627 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 P=0.066 P=0.077 | P=0.186 P=0.485 P=0.238 |
|INCIDENTAL TUMOR | P=0.305 P=0.246 P=0.214 | P=0.201 P=0.567 P=0.238 |
|LOGISTIC REGRESSION | P=0.180 P=0.084 P=0.111 | P=0.186 P=0.511 P=0.238 |
|COCHRAN-ARMITAGE | P=0.195 | P=0.201 |
|FISHER EXACT | P=0.121 P=0.121 | P=0.500 P=0.253 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/49 (0%) 2/49 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 2.7% 6.2% | 0.0% 5.9% 8.6% |
|TERMINAL (d) | 0/38 (0%) 0/23 (0%) 1/24 (4%) | 0/32 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 492 355 | --- 686 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.173 P=0.457 P=0.186 | P=0.125 P=0.228 P=0.115 |
|INCIDENTAL TUMOR | P=0.170 P=0.662 P=0.274 | P=0.092 P=0.166 P=0.134 |
|LOGISTIC REGRESSION | P=0.203 P=0.567 P=0.271 | P=0.126 P=0.224 P=0.118 |
|COCHRAN-ARMITAGE | P=0.195 | P=0.138 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.247 P=0.125 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 7/50 (14%) | 11/49 (22%) 11/49 (22%) 10/50 (20%) |
|ADJUSTED (b) | 7.9% 14.3% 23.0% | 28.8% 32.1% 29.0% |
|TERMINAL (d) | 3/38 (8%) 2/23 (9%) 4/24 (17%) | 6/32 (19%) 9/32 (28%) 8/32 (25%) |
|FIRST INCIDENCE (DAYS) | 731 (T) 492 306 | 612 646 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.274 P=0.056 | P=0.490N P=0.558 P=0.534N |
|INCIDENTAL TUMOR | P=0.079 P=0.466 P=0.132 | P=0.445 P=0.418 P=0.448 |
|LOGISTIC REGRESSION | P=0.114 P=0.410 P=0.160 | P=0.555N P=0.521 P=0.595N |
|COCHRAN-ARMITAGE | P=0.118 | P=0.438N |
|FISHER EXACT | P=0.500 P=0.159 | P=0.595N P=0.479N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 5/50 (10%) | 11/49 (22%) 9/49 (18%) 7/50 (14%) |
|ADJUSTED (b) | 7.9% 12.0% 17.3% | 28.8% 27.0% 21.1% |
|TERMINAL (d) | 3/38 (8%) 2/23 (9%) 3/24 (13%) | 6/32 (19%) 8/32 (25%) 6/32 (19%) |
|FIRST INCIDENCE (DAYS) | 731 (T) 659 306 | 612 646 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.151 P=0.430 P=0.175 | P=0.229N P=0.434N P=0.248N |
|INCIDENTAL TUMOR | P=0.215 P=0.572 P=0.299 | P=0.385N P=0.551N P=0.456N |
|LOGISTIC REGRESSION | P=0.255 P=0.516 P=0.331 | P=0.272N P=0.472N P=0.291N |
|COCHRAN-ARMITAGE | P=0.280 | P=0.194N |
|FISHER EXACT | P=0.661N P=0.357 | P=0.401N P=0.204N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 10/50 (20%) 19/50 (38%) | 10/49 (20%) 10/49 (20%) 22/50 (44%) |
|ADJUSTED (b) | 41.6% 34.8% 58.2% | 27.7% 28.9% 62.8% |
|TERMINAL (d) | 13/38 (34%) 5/23 (22%) 11/24 (46%) | 7/32 (22%) 8/32 (25%) 19/32 (59%) |
|FIRST INCIDENCE (DAYS) | 541 635 515 | 612 595 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.062 P=0.407N P=0.099 | P=0.002 ** P=0.572 P=0.008 ** |
|INCIDENTAL TUMOR | P=0.303 P=0.087N P=0.494 | P<0.001 ** P=0.534 P=0.002 ** |
|LOGISTIC REGRESSION | P=0.176 P=0.162N P=0.344 | P<0.001 ** P=0.532 P=0.002 ** |
|COCHRAN-ARMITAGE | P=0.262 | P=0.003 ** |
|FISHER EXACT | P=0.059N P=0.500 | P=0.599N P=0.010 * |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 24/50 (48%) 25/50 (50%) | 15/49 (31%) 16/49 (33%) 17/50 (34%) |
|ADJUSTED (b) | 33.8% 65.7% 59.1% | 38.1% 41.9% 48.4% |
|TERMINAL (d) | 9/38 (24%) 11/23 (48%) 8/24 (33%) | 8/32 (25%) 10/32 (31%) 14/32 (44%) |
|FIRST INCIDENCE (DAYS) | 390 390 306 | 612 595 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019 * P=0.003 ** P=0.006 ** | P=0.368 P=0.454 P=0.386 |
|INCIDENTAL TUMOR | P=0.159 P=0.128 P=0.168 | P=0.111 P=0.256 P=0.119 |
|LOGISTIC REGRESSION | P=0.103 P=0.040 * P=0.077 | P=0.149 P=0.309 P=0.270 |
|COCHRAN-ARMITAGE | P=0.062 | P=0.429 |
|FISHER EXACT | P=0.050 P=0.033 * | P=0.500 P=0.442 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 26/50 (52%) 37/50 (74%) | 23/49 (47%) 21/49 (43%) 31/50 (62%) |
|ADJUSTED (b) | 54.2% 67.9% 82.2% | 55.7% 55.1% 86.0% |
|TERMINAL (d) | 17/38 (45%) 11/23 (48%) 16/24 (67%) | 14/32 (44%) 15/32 (47%) 27/32 (84%) |
|FIRST INCIDENCE (DAYS) | 390 390 306 | 612 595 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.053 P<0.001 ** | P=0.036 * P=0.481N P=0.072 |
|INCIDENTAL TUMOR | P=0.021 * P=0.563N P=0.055 | P=0.002 ** P=0.500 P=0.005 ** |
|LOGISTIC REGRESSION | P=0.006 ** P=0.492 P=0.015 * | P=0.002 ** P=0.513 P=0.012 * |
|COCHRAN-ARMITAGE | P=0.006 ** | P=0.047 * |
|FISHER EXACT | P=0.500 P=0.011 * | P=0.420N P=0.096 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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