TR 395 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05030 PROBENECID TIME: 15:19:33
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097
CONT: N01CP9561903 CAS: 000057669
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05030 PROBENECID TIME: 15:19:33
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097
CONT: N01CP9561903 CAS: 000057669
PATHOLOGIST: K. MURTHY S. EUSTIS
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 3 310 390 410 522 541 576 582 606 614 |
| 680 682 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 2 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 143 208 239 305 390 416 426 431 443 452 |
| 463 492 515 561 589 635 645 645 645 646 |
| 659 683 707 717 725 |
| CENSORED DEATHS |
| 3 3 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .4G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 20 31 304 306 355 408 438 509 515 568 |
| 568 589 611 611 620 626 634 635 640 646 |
| 667 686 717 722 725 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 98.0 96.0 92.0 92.0 88.0 84.0 80.0 76.0 |
| | |
| | |
|.1G/KG | 100.0 97.9 93.8 91.7 87.5 77.1 72.9 68.8 56.3 47.9 |
| | |
| | |
|.4G/KG | 96.0 96.0 96.0 90.0 88.0 86.0 82.0 76.0 60.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .1G/KG .4G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 47.9% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.050 P=0.009 P=0.011 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 493.0 511.2 533.8 |
|NATURAL DEATHS (C) | (55.5) (33.3) (38.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.9 592.0 628.4 |
|(STANDARD ERROR) | (19.4) (28.3) (24.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 13 539 580 596 603 612 612 648 655 660 |
| 687 687 704 709 709 721 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1G/KG |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 337 347 488 536 547 550 570 595 606 627 |
| 644 646 674 686 694 717 |
| CENSORED DEATHS |
| 108 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .4G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 303 343 343 408 422 475 486 514 527 567 |
| 583 585 586 605 643 672 716 717 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 98.0 98.0 98.0 98.0 95.9 89.8 79.6 65.3 |
| | |
| | |
|.1G/KG | 100.0 100.0 100.0 95.8 95.8 95.8 91.7 83.3 75.0 66.7 |
| | |
| | |
|.4G/KG | 100.0 100.0 100.0 94.0 90.0 88.0 82.0 72.0 70.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .1G/KG .4G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 65.3% 66.7% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.679 P=1.000 P=0.759 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.1 579.0 527.5 |
|NATURAL DEATHS (C) | (39.9) (28.1) (29.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.1 668.0 657.1 |
|(STANDARD ERROR) | (15.7) (17.9) (17.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROBENECID
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.1G/KG = 2
.4G/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 11 3 2
| 1 3 3 2 2 1
| 3 2 2 2 1 1 1
| 2 3 2 1 1
P 90 + 3 2 32 1 1
E | 322 3 1 1
R | 223 33 11 1
C | 2 2 2 3 3 11
E 80 + 2 2 1 1
N | 2 2 3 3
T | 2 2 3 3 1 1
| 2 2 33
S 70 + 2 2 332
U | 32 2
R | 33
V | 33
I 60 + 3 3
V | 2 23 2
A | 2 2 33
L | 2 2
50 + 22
| 2 2
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
PROBENECID
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.1G/KG = 2
.4G/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 22 1
| 2 2 1 1
95 +
| 3 3 2 2 1 1
| 3 3
| 2 2 11
P 90 + 3 3 11
E |
R | 3 3 2 2
C | 3 3 1 1
E 85 + 2 2
N | 3 3 2 2 11
T | 3 3
| 2 2 1 1
S 80 + 3 3 1 1
U | 2 2
R | 22
V |
I 75 + 2 2 1 1
V | 3 3 11
A | 3 3 22
L | 2 2
70 + 3 3 11
| 2 2
| 3 11
| 2 2
65 + 1 1
| 3 3
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
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