TR 395 Rat Pathology Tables
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
Facility: TSI Mason Research
Chemical CAS #: 57-66-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Mesentery | + + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + M + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M M + M + + + M + + M + + + + + M|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma NOS | |
Leukemia Mononuclear | X |
Polyp Stromal | X |
Sarcoma Stromal | |
Bilateral, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
Axillary, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mandibular, Carcinoma, Metastatic, | |
Thyroid Gland | X |
Mandibular, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | |
Fibroadenoma | X X X X X X|
Fibroadenoma, Multiple | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibroma | |
Sarcoma | X |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebrum, Oligodendroglioma Malignant| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | X X |
Leukemia Mononuclear | X X X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 15 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Carcinoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Leukemia Mononuclear | X X X | 6 |
Pheochromocytoma Benign | | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + M M + M + + + + M| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X | 20 |
Pars Distalis, Adenoma, Multiple | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X X X X X | 9 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M M + + + + + + + + + + + + M + M + M + M M| 36 |
Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Benign | X X | 2 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deciduoma NOS | X| 1 |
Leukemia Mononuclear | X | 2 |
Polyp Stromal | X X X X X | 6 |
Sarcoma Stromal | X | 1 |
Bilateral, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + | 23 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Leukemia Mononuclear | X X | 2 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mandibular, Carcinoma, Metastatic, | | |
Thyroid Gland | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X | 7 |
Mediastinal, Leukemia Mononuclear | X X X X X | 9 |
Pancreatic, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 15 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Adenocarcinoma | X X X | 3 |
Fibroadenoma | X X X X X X X X | 14 |
Fibroadenoma, Multiple | X X X X | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Neurofibroma | X | 1 |
Sarcoma | X | 2 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Cerebrum, Oligodendroglioma Malignant| X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Carcinoma, Metastatic, Thyroid Gland | | 2 |
Leukemia Mononuclear | X X X X X X X | 12 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + + + +| 6 |
__________________________________________________________________________|____________|
Eye | + + + + + + + +| 11 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X|
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + M +|
Adenoma | X X X X|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X X X |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Thymus | + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X|
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + + + |
Basal Cell Carcinoma | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + |
Astrocytoma Benign | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + + +|
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + M + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M +| 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + +| 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + +| 30 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X| 16 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 14 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + +| 10 |
__________________________________________________________________________|____________|
Stomach | + + + + +| 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + +| 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + +| 9 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + +| 9 |
Leukemia Mononuclear | X X X| 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + +| 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + +| 13 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + +| 13 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 11 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
Pars Distalis, Adenoma | X X X X X X X X X X| 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X X | 3 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + + + + + + + +| 16 |
Adenoma | X X X| 7 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + +| 16 |
Granulosa Cell Tumor Benign | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + +| 16 |
Leukemia Mononuclear | X | 1 |
Polyp Stromal | X X X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | M + + + +| 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 21 |
Axillary, Leukemia Mononuclear | X X | 3 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 4 |
Mandibular, Leukemia Mononuclear | X X X | 4 |
Mediastinal, Leukemia Mononuclear | X X X X | 7 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
Renal, Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + +| 20 |
Leukemia Mononuclear | X X X X X| 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X X X X X X X X| 14 |
__________________________________________________________________________|____________|
Thymus | + + + + +| 10 |
Leukemia Mononuclear | X X X| 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 28 |
Adenocarcinoma | X | 1 |
Fibroadenoma | X X X X X X X X X X X| 17 |
Fibroadenoma, Multiple | X X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + +| 12 |
Basal Cell Carcinoma | X | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | M + + + +| 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 10 |
Astrocytoma Benign | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + +| 26 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Leukemia Mononuclear | X X X| 5 |
__________________________________________________________________________|____________|
Nose | + + + + +| 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 4 |
__________________________________________________________________________|____________|
Eye | + + + + + + | 13 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + +| 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant Histiocytic | X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + |
Histiocytic Sarcoma | |
Sarcoma Stromal, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + A|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + M + + + + + + + + + + + + M + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M M M + + + + + + M + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Carcinoma | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arrhenoblastoma Benign | |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Adenoma | |
Leiomyosarcoma | |
Leukemia Mononuclear | |
Polyp Stromal | X X X X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Mandibular, Carcinoma, Metastatic, | |
Thyroid Gland | X |
Mandibular, Leukemia Mononuclear | X X |
Mandibular, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Undifferentiated Cell Type | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + + + + M + M + M M|
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Thyroid Gland | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + A + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + M + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + A M + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X | 16 |
Lymphoma Malignant Histiocytic | | 1 |
Neoplastic Nodule | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + +| 6 |
Histiocytic Sarcoma | X | 1 |
Sarcoma Stromal, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Adenoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + M + + + + + + + +| 45 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X | 4 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M M + + M + M + + + + + + + M M M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X | 15 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Bilateral, C-Cell, Carcinoma | | 1 |
C-Cell, Adenoma | X | 1 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + M + + + + + + + + + + + + + + + + + M| 45 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arrhenoblastoma Benign | X | 1 |
Granulosa Cell Tumor Benign | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Leiomyosarcoma | X | 1 |
Leukemia Mononuclear | X X | 2 |
Polyp Stromal | X X X X X | 9 |
Sarcoma Stromal | X X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 18 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | | 1 |
Mandibular, Carcinoma, Metastatic, | | |
Thyroid Gland | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X | 7 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X | 8 |
Pancreatic, Leukemia Mononuclear | X X | 3 |
Renal, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 17 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + M + + + M + + M M + + + + M M + + + +| 36 |
Fibroadenoma | X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X | 17 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + + + + |
Mesothelioma Benign | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M M M + + + + + + + + M + + + M M + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X|
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X |
Tunic, Mesothelioma Benign | |
Tunic, Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Bronchial, Mediastinal, Fibrosarcoma,| |
Metastatic, Skin | X |
Lumbar, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Epithelial Cell, Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M M M + M M M + + + + M + + M + M M + +|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
Leukemia Mononuclear | |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | X X X X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosarcoma, Metastatic, Skin | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Benign | |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + M + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 6 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Adenoma | X | 2 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X X X X X X X X X X | 14 |
Bilateral, Pheochromocytoma Benign | X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
C-Cell, Adenoma | X X X X X | 9 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X | 6 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X| 42 |
Interstitial Cell, Adenoma | X X | 3 |
Tunic, Mesothelioma Benign | X | 1 |
Tunic, Mesothelioma Malignant | X X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + | 31 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | X | 1 |
Bronchial, Mediastinal, Fibrosarcoma,| | |
Metastatic, Skin | | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Leukemia Mononuclear | X X X | 3 |
Mediastinal, Leukemia Mononuclear | X X | 2 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + + + + + + + + + + + + M M + +| 46 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X | 1 |
Epithelial Cell, Thymoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M M + M + + M M M M M M + M + M + + +| 26 |
Fibroadenoma | X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basal Cell Adenoma | X | 1 |
Keratoacanthoma | X | 2 |
Leukemia Mononuclear | X | 1 |
Trichoepithelioma | X | 1 |
Subcutaneous Tissue, Fibroma | X| 5 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X| 3 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Basosquamous Tumor Benign | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 6 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X|
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + +|
Mesothelioma Malignant | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Prostate | + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X |
Bilateral, Interstitial Tissue, | |
Adenoma | X |
Interstitial Cell, Adenoma | X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Mediastinal, Fibrous Histiocytoma, | |
Metastatic, Skin | X |
Mediastinal, Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X|
Mediastinal, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + +|
Leukemia Mononuclear | X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + +|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + +|
Basal Cell Adenoma | X |
Basal Cell Carcinoma | |
Fibrous Histiocytoma | X |
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leukemia Mononuclear | X|
__________________________________________________________________________|
Nose | + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + + |
Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + | 8 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 41 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X| 9 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 20 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 16 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 12 |
Mesothelioma Malignant | X | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 8 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X X X X X| 16 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 19 |
Adenoma | X | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + +| 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 26 |
Leukemia Mononuclear | X X | 2 |
Pars Distalis, Adenoma | X X X | 12 |
Pars Distalis, Adenoma, Multiple | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 12 |
C-Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 26 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 15 |
Adenoma | X | 2 |
Carcinoma | X | 2 |
Bilateral, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 30 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + +| 44 |
Leukemia Mononuclear | X X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| 33 |
Bilateral, Interstitial Tissue, | | |
Adenoma | | 1 |
Interstitial Cell, Adenoma | X X X | 5 |
Tunic, Mesothelioma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 27 |
Mediastinal, Fibrous Histiocytoma, | | |
Metastatic, Skin | | 1 |
Mediastinal, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Mandibular, Leukemia Mononuclear | | 1 |
Mediastinal, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 19 |
Leukemia Mononuclear | X X X X X X X| 10 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 14 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + | 9 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 20 |
Basal Cell Adenoma | | 1 |
Basal Cell Carcinoma | X | 1 |
Fibrous Histiocytoma | | 1 |
Keratoacanthoma | X | 1 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 1 |
Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 8 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 18 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 8 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 10 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 10 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Leiomyoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
__________________________________________________________________________|
Mesentery | + + + + + |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
Mesothelioma Malignant, Metastatic | |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + + M + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
C-Cell, Adenoma | X X X X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + M +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | X |
Bilateral, Adenoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X|
Tunic, Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X|
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M M + + M M + + + + M M M + + M + M + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Granular Cell Tumor Benign | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
Pleura, Mesothelioma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X|
Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 2 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Malignant, Metastatic | X | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | X X X X X | 6 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + + M + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X X X X X| 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Carcinoma | | 1 |
C-Cell, Adenoma | X X X X X X | 10 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X | 7 |
Carcinoma | | 1 |
Bilateral, Adenoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | 37 |
Interstitial Cell, Adenoma | X X X| 7 |
Tunic, Mesothelioma Malignant | X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + | 21 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + A + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + M +| 47 |
Leukemia Mononuclear | X| 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X| 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + + + + + + + + + + + M + M +| 46 |
Leukemia Mononuclear | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + M M M + M M M + + M + + + M + + + M + M| 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X | 1 |
Granular Cell Tumor Benign | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05030-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PROBENECID Date: 04/10/97
Route: GAVAGE Time: 09:45:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X| 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pleura, Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + + +| 11 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Malignant | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
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