TR 395 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 01 TIME: 13:50:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 57-66-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 01 TIME: 13:50:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 57-66-9
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PROBENECID DATE: 09/04/94
EXPERIMENT: 05030 TEST: 01 TIME: 13:50:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: GAVAGE NTP C#: 56097
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 57-66-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PROBENECID
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Islets, Pancreatic Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/13 (0%) 1/49 (2%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% | 4.2% 0.0% 3.4% |
|TERMINAL (d) | 2/36 (6%) 0/34 (0%) 0/22 (0%) | 1/24 (4%) 0/3 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) --- --- | 729 (T) --- 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.300N P=0.251N P=0.352N | P=0.598 P=0.892N P=0.697 |
|INCIDENTAL TUMOR | P=0.300N P=0.251N P=0.352N | P=0.616 P=0.892N P=0.689 |
|LOGISTIC REGRESSION | P=0.300N P=0.251N P=0.352N | P=0.636 P=0.892N P=0.718 |
|COCHRAN-ARMITAGE | P=0.219N | P=0.678 |
|FISHER EXACT | P=0.242N P=0.242N | P=0.794N P=0.747 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/49 (39%) 18/50 (36%) 8/50 (16%) | 2/48 (4%) 1/13 (8%) 1/45 (2%) |
|ADJUSTED (b) | 49.9% 45.9% 31.9% | 6.4% 33.3% 6.3% |
|TERMINAL (d) | 17/36 (47%) 13/34 (38%) 6/22 (27%) | 1/24 (4%) 1/3 (33%) 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 707 631 562 | 635 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.143N P=0.565 P=0.183N | P=0.542N P=0.628 P=0.628N |
|INCIDENTAL TUMOR | P=0.029N* P=0.551N P=0.076N | P=0.481N P=0.609 P=0.553N |
|LOGISTIC REGRESSION | P=0.022N* P=0.580N P=0.045N* | P=0.497N P=0.463 P=0.599N |
|COCHRAN-ARMITAGE | P=0.006N** | P=0.417N |
|FISHER EXACT | P=0.469N P=0.010N** | P=0.519 P=0.524N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/49 (41%) 19/50 (38%) 8/50 (16%) | 2/48 (4%) 1/13 (8%) 1/45 (2%) |
|ADJUSTED (b) | 52.5% 48.5% 31.9% | 6.4% 33.3% 6.3% |
|TERMINAL (d) | 18/36 (50%) 14/34 (41%) 6/22 (27%) | 1/24 (4%) 1/3 (33%) 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 707 631 562 | 635 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.106N P=0.560 P=0.140N | P=0.542N P=0.628 P=0.628N |
|INCIDENTAL TUMOR | P=0.019N* P=0.555N P=0.054N | P=0.481N P=0.609 P=0.553N |
|LOGISTIC REGRESSION | P=0.014N* P=0.585 P=0.030N* | P=0.497N P=0.463 P=0.599N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.417N |
|FISHER EXACT | P=0.468N P=0.006N** | P=0.519 P=0.524N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 3/15 (20%) 9/50 (18%) | 3/36 (8%) 7/16 (44%) 1/45 (2%) |
|ADJUSTED (b) | 14.1% 34.8% 26.8% | 10.2% 64.2% 5.3% |
|TERMINAL (d) | 3/37 (8%) 2/6 (33%) 3/22 (14%) | 1/20 (5%) 5/8 (63%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 551 582 491 | 649 593 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074 P=0.539 P=0.123 | P=0.148N P=0.027 * P=0.368N |
|INCIDENTAL TUMOR | P=0.395 P=0.291 P=0.480 | P=0.064N P=0.010 ** P=0.373N |
|LOGISTIC REGRESSION | P=0.334 P=0.401 P=0.373 | P=0.074N P=0.003 ** P=0.277N |
|COCHRAN-ARMITAGE | P=0.315 | P=0.048N* |
|FISHER EXACT | P=0.352 P=0.303 | P=0.006 ** P=0.229N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/15 (13%) 1/50 (2%) | 0/36 (0%) 1/16 (6%) 0/45 (0%) |
|ADJUSTED (b) | 0.0% 33.3% 4.3% | 0.0% 12.5% 0.0% |
|TERMINAL (d) | 0/37 (0%) 2/6 (33%) 0/22 (0%) | 0/20 (0%) 1/8 (13%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) 727 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463 P=0.006 ** P=0.400 | P=0.650N P=0.318 (e) |
|INCIDENTAL TUMOR | P=0.627 P=0.006 ** P=0.665 | P=0.650N P=0.318 (e) |
|LOGISTIC REGRESSION | P=0.506 P=0.006 ** P=0.429 | P=0.650N P=0.318 (e) |
|COCHRAN-ARMITAGE | P=0.640 | P=0.602N |
|FISHER EXACT | P=0.052 P=0.505 | P=0.308 (e) |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 5/15 (33%) 10/50 (20%) | 3/36 (8%) 8/16 (50%) 1/45 (2%) |
|ADJUSTED (b) | 14.1% 67.4% 29.9% | 10.2% 76.1% 5.3% |
|TERMINAL (d) | 3/37 (8%) 4/6 (67%) 3/22 (14%) | 1/20 (5%) 6/8 (75%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 551 582 491 | 649 593 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.056 P=0.111 P=0.074 | P=0.127N P=0.009 ** P=0.368N |
|INCIDENTAL TUMOR | P=0.378 P=0.022 * P=0.409 | P=0.054N P=0.003 ** P=0.373N |
|LOGISTIC REGRESSION | P=0.311 P=0.047 * P=0.269 | P=0.064N P<0.001 ** P=0.277N |
|COCHRAN-ARMITAGE | P=0.310 | P=0.038N* |
|FISHER EXACT | P=0.071 P=0.220 | P=0.002 ** P=0.229N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 2/19 (11%) 3/49 (6%) | 0/50 (0%) 1/11 (9%) 2/50 (4%) |
|ADJUSTED (b) | 5.6% 14.9% 10.7% | 0.0% 100.0% 9.6% |
|TERMINAL (d) | 2/36 (6%) 1/8 (13%) 1/22 (5%) | 0/24 (0%) 1/1 (100%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 699 703 | --- 729 (T) 705 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.313 P=0.277 P=0.319 | P=0.207 P=0.009 ** P=0.189 |
|INCIDENTAL TUMOR | P=0.574 P=0.206 P=0.501 | P=0.241 P=0.009 ** P=0.180 |
|LOGISTIC REGRESSION | P=0.446 P=0.183 P=0.404 | P=0.241 P=0.009 ** P=0.184 |
|COCHRAN-ARMITAGE | P=0.530 | P=0.292 |
|FISHER EXACT | P=0.310 P=0.500 | P=0.180 P=0.247 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 3/19 (16%) 3/49 (6%) | 0/50 (0%) 1/11 (9%) 2/50 (4%) |
|ADJUSTED (b) | 5.6% 27.1% 10.7% | 0.0% 100.0% 9.6% |
|TERMINAL (d) | 2/36 (6%) 2/8 (25%) 1/22 (5%) | 0/24 (0%) 1/1 (100%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 699 703 | --- 729 (T) 705 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.358 P=0.073 P=0.319 | P=0.207 P=0.009 ** P=0.189 |
|INCIDENTAL TUMOR | P=0.605 P=0.046 * P=0.501 | P=0.241 P=0.009 ** P=0.180 |
|LOGISTIC REGRESSION | P=0.498 P=0.037 * P=0.404 | P=0.241 P=0.009 ** P=0.184 |
|COCHRAN-ARMITAGE | P=0.593 | P=0.292 |
|FISHER EXACT | P=0.129 P=0.500 | P=0.180 P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/41 (2%) 0/50 (0%) | 0/50 (0%) 1/30 (3%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 3.4% 0.0% | 0.0% 5.9% 9.8% |
|TERMINAL (d) | 1/37 (3%) 1/29 (3%) 0/22 (0%) | 0/24 (0%) 1/17 (6%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) --- | --- 729 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.472N P=0.707 P=0.604N | P=0.148 P=0.431 P=0.188 |
|INCIDENTAL TUMOR | P=0.472N P=0.707 P=0.604N | P=0.175 P=0.431 P=0.180 |
|LOGISTIC REGRESSION | P=0.472N P=0.707 P=0.604N | P=0.162 P=0.431 P=0.181 |
|COCHRAN-ARMITAGE | P=0.354N | P=0.239 |
|FISHER EXACT | P=0.701 P=0.500N | P=0.375 P=0.247 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/41 (5%) 0/50 (0%) | 0/50 (0%) 1/30 (3%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 6.9% 0.0% | 0.0% 5.9% 9.8% |
|TERMINAL (d) | 1/37 (3%) 2/29 (7%) 0/22 (0%) | 0/24 (0%) 1/17 (6%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) --- | --- 729 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429N P=0.415 P=0.604N | P=0.148 P=0.431 P=0.188 |
|INCIDENTAL TUMOR | P=0.429N P=0.415 P=0.604N | P=0.175 P=0.431 P=0.180 |
|LOGISTIC REGRESSION | P=0.429N P=0.415 P=0.604N | P=0.162 P=0.431 P=0.181 |
|COCHRAN-ARMITAGE | P=0.293N | P=0.239 |
|FISHER EXACT | P=0.425 P=0.500N | P=0.375 P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/41 (5%) 0/50 (0%) | 0/50 (0%) 1/30 (3%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 6.9% 0.0% | 0.0% 5.9% 9.8% |
|TERMINAL (d) | 1/37 (3%) 2/29 (7%) 0/22 (0%) | 0/24 (0%) 1/17 (6%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) --- | --- 729 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429N P=0.415 P=0.604N | P=0.148 P=0.431 P=0.188 |
|INCIDENTAL TUMOR | P=0.429N P=0.415 P=0.604N | P=0.175 P=0.431 P=0.180 |
|LOGISTIC REGRESSION | P=0.429N P=0.415 P=0.604N | P=0.162 P=0.431 P=0.181 |
|COCHRAN-ARMITAGE | P=0.293N | P=0.239 |
|FISHER EXACT | P=0.425 P=0.500N | P=0.375 P=0.247 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/18 (11%) 6/50 (12%) | 2/50 (4%) 2/26 (8%) 1/50 (2%) |
|ADJUSTED (b) | 7.7% 16.0% 22.3% | 8.3% 9.1% 4.2% |
|TERMINAL (d) | 2/37 (5%) 1/7 (14%) 4/22 (18%) | 2/24 (8%) 1/15 (7%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 671 462 580 | 729 (T) 721 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.078 P=0.482 P=0.093 | P=0.490N P=0.598 P=0.576N |
|INCIDENTAL TUMOR | P=0.205 P=0.535 P=0.180 | P=0.456N P=0.401 P=0.593N |
|LOGISTIC REGRESSION | P=0.231 P=0.471 P=0.204 | P=0.460N P=0.492 P=0.586N |
|COCHRAN-ARMITAGE | P=0.240 | P=0.357N |
|FISHER EXACT | P=0.399 P=0.243 | P=0.423 P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 9.7% 2.9% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/34 (0%) 0/22 (0%) | 1/24 (4%) 1/35 (3%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 652 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.147N P=0.214N P=0.171N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.149N P=0.380N P=0.179N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.129N P=0.295N P=0.149N |
|COCHRAN-ARMITAGE | (e) | P=0.107N |
|FISHER EXACT | (e) (e) | P=0.309N P=0.121N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 0/50 (0%) | 24/50 (48%) 23/50 (46%) 5/50 (10%) |
|ADJUSTED (b) | 7.8% 5.3% 0.0% | 65.7% 48.8% 15.6% |
|TERMINAL (d) | 2/37 (5%) 1/34 (3%) 0/22 (0%) | 12/24 (50%) 11/35 (31%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 708 650 --- | 593 537 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.170N P=0.539N P=0.222N | P=0.002N** P=0.149N P=0.002N** |
|INCIDENTAL TUMOR | P=0.081N P=0.499N P=0.125N | P<0.001N** P=0.448 P<0.001N** |
|LOGISTIC REGRESSION | P=0.114N P=0.516N P=0.165N | P<0.001N** P=0.479N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.098N | P<0.001N** |
|FISHER EXACT | P=0.500N P=0.121N | P=0.500N P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 0/50 (0%) | 24/50 (48%) 23/50 (46%) 5/50 (10%) |
|ADJUSTED (b) | 7.8% 5.3% 0.0% | 65.7% 48.8% 15.6% |
|TERMINAL (d) | 2/37 (5%) 1/34 (3%) 0/22 (0%) | 12/24 (50%) 11/35 (31%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 708 650 --- | 593 537 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.170N P=0.539N P=0.222N | P=0.002N** P=0.149N P=0.002N** |
|INCIDENTAL TUMOR | P=0.081N P=0.499N P=0.125N | P<0.001N** P=0.448 P<0.001N** |
|LOGISTIC REGRESSION | P=0.114N P=0.516N P=0.165N | P<0.001N** P=0.479N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.098N | P<0.001N** |
|FISHER EXACT | P=0.500N P=0.121N | P=0.500N P<0.001N** |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 1/16 (6%) 1/50 (2%) |
|ADJUSTED (b) | | 7.5% 16.7% 2.7% |
|TERMINAL (d) | | 1/24 (4%) 1/6 (17%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | | 704 729 (T) 592 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.524N P=0.738 P=0.578N |
|INCIDENTAL TUMOR | | P=0.448N P=0.478 P=0.525N |
|LOGISTIC REGRESSION | | P=0.459N P=0.538 P=0.546N |
|COCHRAN-ARMITAGE | | P=0.399N |
|FISHER EXACT | | P=0.572 P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 14/26 (54%) 17/50 (34%) | 22/50 (44%) 26/50 (52%) 16/50 (32%) |
|ADJUSTED (b) | 35.3% 74.0% 49.9% | 60.7% 63.2% 60.0% |
|TERMINAL (d) | 10/37 (27%) 10/14 (71%) 7/22 (32%) | 11/24 (46%) 20/35 (57%) 9/19 (47%) |
|FIRST INCIDENCE (DAYS) | 610 462 513 | 544 592 557 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.083 P=0.045 * P=0.076 | P=0.490N P=0.356N P=0.466N |
|INCIDENTAL TUMOR | P=0.534N P=0.018 * P=0.488 | P=0.249N P=0.317 P=0.353N |
|LOGISTIC REGRESSION | P=0.505 P=0.013 * P=0.352 | P=0.294N P=0.339 P=0.385N |
|COCHRAN-ARMITAGE | P=0.540N | P=0.070N |
|FISHER EXACT | P=0.038 * P=0.415 | P=0.274 P=0.151N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 2.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/37 (5%) 0/34 (0%) 0/22 (0%) | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 694 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275N P=0.531N P=0.358N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.192N P=0.504N P=0.358N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.228N P=0.521N P=0.358N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.195N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.0% 2.9% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/34 (0%) 0/22 (0%) | 1/24 (4%) 1/35 (3%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 663 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.251N P=0.392N P=0.296N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.250N P=0.507N P=0.304N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.236N P=0.474N P=0.280N |
|COCHRAN-ARMITAGE | (e) | P=0.195N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.9% 4.2% | 4.2% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 2/34 (6%) 0/22 (0%) | 1/24 (4%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) 723 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423 P=0.220 P=0.408 | P=0.520N P=0.425N P=0.547N |
|INCIDENTAL TUMOR | P=0.563 P=0.220 P=0.665 | P=0.520N P=0.425N P=0.547N |
|LOGISTIC REGRESSION | P=0.467 P=0.220 P=0.447 | P=0.520N P=0.425N P=0.547N |
|COCHRAN-ARMITAGE | P=0.568 | P=0.461N |
|FISHER EXACT | P=0.247 P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 5.9% 4.5% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 2/37 (5%) 2/34 (6%) 1/22 (5%) | 0/24 (0%) 1/35 (3%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 730 (T) | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.609N P=0.665 P=0.678N | P=0.760N P=0.575 (e) |
|INCIDENTAL TUMOR | P=0.609N P=0.665 P=0.678N | P=0.760N P=0.575 (e) |
|LOGISTIC REGRESSION | P=0.609N P=0.665 P=0.678N | P=0.760N P=0.575 (e) |
|COCHRAN-ARMITAGE | P=0.412N | P=0.689N |
|FISHER EXACT | P=0.691N P=0.500N | P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 10.8% 14.1% 8.5% | 4.2% 2.9% 0.0% |
|TERMINAL (d) | 4/37 (11%) 4/34 (12%) 1/22 (5%) | 1/24 (4%) 1/35 (3%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 694 723 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.486N P=0.446 P=0.585N | P=0.436N P=0.676N P=0.547N |
|INCIDENTAL TUMOR | P=0.351N P=0.462 P=0.479N | P=0.436N P=0.676N P=0.547N |
|LOGISTIC REGRESSION | P=0.383N P=0.442 P=0.547N | P=0.436N P=0.676N P=0.547N |
|COCHRAN-ARMITAGE | P=0.240N | P=0.364N |
|FISHER EXACT | P=0.500 P=0.339N | P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 12.2% 8.6% 11.1% | 4.2% 0.0% 0.0% |
|TERMINAL (d) | 3/37 (8%) 2/34 (6%) 1/22 (5%) | 1/24 (4%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 610 723 670 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.599N P=0.404N P=0.576N | P=0.520N P=0.425N P=0.547N |
|INCIDENTAL TUMOR | P=0.303N P=0.388N P=0.302N | P=0.520N P=0.425N P=0.547N |
|LOGISTIC REGRESSION | P=0.425N P=0.371N P=0.394N | P=0.520N P=0.425N P=0.547N |
|COCHRAN-ARMITAGE | P=0.368N | P=0.461N |
|FISHER EXACT | P=0.357N P=0.357N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.1% 2.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/34 (3%) 0/22 (0%) | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 447 730 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234N P=0.517N P=0.252N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.128N P=0.399N P=0.065N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.149N P=0.456N P=0.154N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.195N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 5/50 (10%) 5/50 (10%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 15.8% 13.6% 16.7% | 4.2% 0.0% 0.0% |
|TERMINAL (d) | 3/37 (8%) 3/34 (9%) 1/22 (5%) | 1/24 (4%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 447 664 670 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550 P=0.433N P=0.598N | P=0.520N P=0.425N P=0.547N |
|INCIDENTAL TUMOR | P=0.198N P=0.348N P=0.162N | P=0.520N P=0.425N P=0.547N |
|LOGISTIC REGRESSION | P=0.379N P=0.353N P=0.333N | P=0.520N P=0.425N P=0.547N |
|COCHRAN-ARMITAGE | P=0.391N | P=0.461N |
|FISHER EXACT | P=0.380N P=0.380N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.1% 5.4% 6.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/34 (3%) 0/22 (0%) | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 447 664 700 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562 P=0.674 P=0.634 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.381N P=0.607N P=0.357N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.583N P=0.661N P=0.615N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.643 | (e) |
|FISHER EXACT | P=0.691N P=0.691N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.5% 6.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/34 (0%) 0/22 (0%) | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 664 700 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.154 P=0.490 P=0.184 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.429 P=0.527 P=0.432 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.189 P=0.509 P=0.216 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.195 | (e) |
|FISHER EXACT | P=0.500 P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/49 (92%) 39/44 (89%) 44/50 (88%) | |
|ADJUSTED (b) | 100.0% 100.0% 97.8% | |
|TERMINAL (d) | 36/36 (100%) 29/29 (100%) 21/22 (95%) | |
|FIRST INCIDENCE (DAYS) | 551 503 499 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.433 P=0.003 ** | |
|INCIDENTAL TUMOR | P=0.391 P=0.475 P=0.459 | |
|LOGISTIC REGRESSION | P=0.354 P=0.551 P=0.466 | |
|COCHRAN-ARMITAGE | P=0.382N | |
|FISHER EXACT | P=0.431N P=0.383N | |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 3/12 (25%) 10/49 (20%) | 9/49 (18%) 3/50 (6%) 1/47 (2%) |
|ADJUSTED (b) | 24.3% 100.0% 35.7% | 28.3% 8.2% 5.3% |
|TERMINAL (d) | 9/37 (24%) 3/3 (100%) 6/22 (27%) | 3/23 (13%) 2/35 (6%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 574 | 635 721 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115 P=0.019 * P=0.130 | P=0.032N* P=0.021N* P=0.031N* |
|INCIDENTAL TUMOR | P=0.241 P=0.019 * P=0.246 | P=0.023N* P=0.120N P=0.022N* |
|LOGISTIC REGRESSION | P=0.365 P=0.019 * P=0.355 | P=0.023N* P=0.040N* P=0.021N* |
|COCHRAN-ARMITAGE | P=0.505 | P=0.014N* |
|FISHER EXACT | P=0.435 P=0.500 | P=0.056N P=0.009N** |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/12 (0%) 0/49 (0%) | 3/49 (6%) 1/50 (2%) 2/47 (4%) |
|ADJUSTED (b) | 2.7% 0.0% 0.0% | 11.2% 2.9% 9.1% |
|TERMINAL (d) | 1/37 (3%) 0/3 (0%) 0/22 (0%) | 2/23 (9%) 1/35 (3%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) --- --- | 651 729 (T) 698 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.507N P=0.947N P=0.604N | P=0.615 P=0.195N P=0.606N |
|INCIDENTAL TUMOR | P=0.507N P=0.947N P=0.604N | P=0.641 P=0.260N P=0.626N |
|LOGISTIC REGRESSION | P=0.507N P=0.947N P=0.604N | P=0.645 P=0.261N P=0.595N |
|COCHRAN-ARMITAGE | P=0.419N | P=0.571N |
|FISHER EXACT | P=0.803N P=0.500N | P=0.301N P=0.520N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 3/12 (25%) 10/49 (20%) | 12/49 (24%) 4/50 (8%) 3/47 (6%) |
|ADJUSTED (b) | 24.3% 100.0% 35.7% | 37.2% 11.0% 13.9% |
|TERMINAL (d) | 9/37 (24%) 3/3 (100%) 6/22 (27%) | 5/23 (22%) 3/35 (9%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 574 | 635 721 698 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115 P=0.019 * P=0.130 | P=0.069N P=0.006N** P=0.049N* |
|INCIDENTAL TUMOR | P=0.241 P=0.019 * P=0.246 | P=0.043N* P=0.046N* P=0.034N* |
|LOGISTIC REGRESSION | P=0.365 P=0.019 * P=0.355 | P=0.046N* P=0.015N* P=0.031N* |
|COCHRAN-ARMITAGE | P=0.505 | P=0.025N* |
|FISHER EXACT | P=0.435 P=0.500 | P=0.024N* P=0.014N* |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/12 (0%) 2/49 (4%) | 1/49 (2%) 1/50 (2%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 6.9% | 4.3% 2.9% 5.3% |
|TERMINAL (d) | 0/37 (0%) 0/3 (0%) 1/22 (5%) | 1/23 (4%) 1/35 (3%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 588 | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.086 (e) P=0.171 | P=0.624 P=0.665N P=0.720 |
|INCIDENTAL TUMOR | P=0.130 (e) P=0.222 | P=0.624 P=0.665N P=0.720 |
|LOGISTIC REGRESSION | P=0.157 (e) P=0.253 | P=0.624 P=0.665N P=0.720 |
|COCHRAN-ARMITAGE | P=0.155 | P=0.685 |
|FISHER EXACT | (e) P=0.247 | P=0.747N P=0.742 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 7/50 (14%) 10/50 (20%) 9/50 (18%) |
|ADJUSTED (b) | | 20.4% 23.9% 34.8% |
|TERMINAL (d) | | 2/24 (8%) 5/35 (14%) 5/19 (26%) |
|FIRST INCIDENCE (DAYS) | | 510 551 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.194 P=0.497 P=0.232 |
|INCIDENTAL TUMOR | | P=0.351 P=0.159 P=0.271 |
|LOGISTIC REGRESSION | | P=0.360 P=0.297 P=0.304 |
|COCHRAN-ARMITAGE | | P=0.441 |
|FISHER EXACT | | P=0.298 P=0.393 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 2.2% 0.0% 6.5% |
|TERMINAL (d) | | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | | 544 --- 605 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.235 P=0.496N P=0.422 |
|INCIDENTAL TUMOR | | P=0.335 P=0.773N P=0.469 |
|LOGISTIC REGRESSION | | P=0.356 P=0.448N P=0.553 |
|COCHRAN-ARMITAGE | | P=0.303 |
|FISHER EXACT | | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 8/50 (16%) 10/50 (20%) 11/50 (22%) |
|ADJUSTED (b) | | 22.2% 23.9% 39.0% |
|TERMINAL (d) | | 2/24 (8%) 5/35 (14%) 5/19 (26%) |
|FIRST INCIDENCE (DAYS) | | 510 551 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.107 P=0.595 P=0.162 |
|INCIDENTAL TUMOR | | P=0.236 P=0.190 P=0.192 |
|LOGISTIC REGRESSION | | P=0.254 P=0.397 P=0.244 |
|COCHRAN-ARMITAGE | | P=0.306 |
|FISHER EXACT | | P=0.398 P=0.306 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 10/50 (20%) 7/50 (14%) | 15/50 (30%) 17/50 (34%) 17/50 (34%) |
|ADJUSTED (b) | 16.2% 22.9% 20.3% | 40.1% 41.6% 58.4% |
|TERMINAL (d) | 6/37 (16%) 3/34 (9%) 2/22 (9%) | 5/24 (21%) 12/35 (34%) 8/19 (42%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 462 491 | 510 97 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.338 P=0.180 P=0.242 | P=0.106 P=0.418N P=0.187 |
|INCIDENTAL TUMOR | P=0.352N P=0.333 P=0.535 | P=0.263 P=0.341 P=0.197 |
|LOGISTIC REGRESSION | P=0.482N P=0.229 P=0.516 | P=0.298 P=0.413 P=0.252 |
|COCHRAN-ARMITAGE | P=0.562N | P=0.426 |
|FISHER EXACT | P=0.207 P=0.500 | P=0.415 P=0.415 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% | 0.0% 2.9% 12.7% |
|TERMINAL (d) | 0/37 (0%) 0/34 (0%) 0/22 (0%) | 0/24 (0%) 1/35 (3%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 499 | --- 729 (T) 670 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304 (e) P=0.492 | P=0.031 * P=0.575 P=0.090 |
|INCIDENTAL TUMOR | P=0.475 (e) P=0.814 | P=0.044 * P=0.575 P=0.073 |
|LOGISTIC REGRESSION | P=0.352 (e) P=0.560 | P=0.041 * P=0.575 P=0.086 |
|COCHRAN-ARMITAGE | P=0.311 | P=0.075 |
|FISHER EXACT | (e) P=0.500 | P=0.500 P=0.121 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% | 0.0% 0.0% 9.2% |
|TERMINAL (d) | 0/37 (0%) 0/34 (0%) 0/22 (0%) | 0/24 (0%) 0/35 (0%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 499 | --- --- 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304 (e) P=0.492 | P=0.048 * (e) P=0.195 |
|INCIDENTAL TUMOR | P=0.475 (e) P=0.814 | P=0.065 (e) P=0.180 |
|LOGISTIC REGRESSION | P=0.352 (e) P=0.560 | P=0.056 (e) P=0.187 |
|COCHRAN-ARMITAGE | P=0.311 | P=0.092 |
|FISHER EXACT | (e) P=0.500 | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 12.2% 5.1% 15.8% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/37 (5%) 1/34 (3%) 1/22 (5%) | 0/24 (0%) 0/35 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 653 616 600 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267 P=0.261N P=0.396 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.512N P=0.224N P=0.388N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.450 P=0.220N P=0.604 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.465 | (e) |
|FISHER EXACT | P=0.218N P=0.630N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 46/50 (92%) 47/50 (94%) | 41/50 (82%) 39/50 (78%) 29/50 (58%) |
|ADJUSTED (b) | 100.0% 97.9% 100.0% | 93.0% 81.3% 84.6% |
|TERMINAL (d) | 37/37 (100%) 33/34 (97%) 22/22 (100%) | 21/24 (88%) 26/35 (74%) 14/19 (74%) |
|FIRST INCIDENCE (DAYS) | 551 462 491 | 510 537 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.356 P<0.001 ** | P=0.481N P=0.030N* P=0.332N |
|INCIDENTAL TUMOR | P=0.191 P=0.541 P=0.153 | P=0.057N P=0.518N P=0.093N |
|LOGISTIC REGRESSION | P=0.156 P=0.696 P=0.214 | P=0.071N P=0.394N P=0.099N |
|COCHRAN-ARMITAGE | P=0.564 | P=0.003N** |
|FISHER EXACT | P=0.500N P=0.661N | P=0.402N P=0.008N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .1G/KG .4G/KG | VEHICLE .1G/KG .4G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 23/50 (46%) 21/50 (42%) | 27/50 (54%) 21/50 (42%) 24/50 (48%) |
|ADJUSTED (b) | 35.0% 50.4% 49.7% | 63.3% 51.7% 72.2% |
|TERMINAL (d) | 10/37 (27%) 12/34 (35%) 4/22 (18%) | 10/24 (42%) 16/35 (46%) 10/19 (53%) |
|FIRST INCIDENCE (DAYS) | 447 462 372 | 495 97 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041 * P=0.066 P=0.029 * | P=0.167 P=0.033N* P=0.383 |
|INCIDENTAL TUMOR | P=0.447N P=0.148 P=0.544 | P=0.385 P=0.274N P=0.415 |
|LOGISTIC REGRESSION | P=0.537 P=0.114 P=0.380 | P=0.471 P=0.161N P=0.567 |
|COCHRAN-ARMITAGE | P=0.240 | P=0.443N |
|FISHER EXACT | P=0.074 P=0.149 | P=0.158N P=0.345N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 48/50 (96%) 48/50 (96%) | 49/50 (98%) 46/50 (92%) 37/50 (74%) |
|ADJUSTED (b) | 100.0% 98.0% 100.0% | 98.0% 93.9% 94.8% |
|TERMINAL (d) | 37/37 (100%) 33/34 (97%) 22/22 (100%) | 23/24 (96%) 32/35 (91%) 17/19 (89%) |
|FIRST INCIDENCE (DAYS) | 447 462 372 | 354 97 495 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.293 P=0.001 ** | P=0.446 P=0.012N* P=0.444N |
|INCIDENTAL TUMOR | P=0.565 P=0.755 P=0.480 | P=0.008N** P=0.333N P=0.022N* |
|LOGISTIC REGRESSION | P=0.446 P=0.652 P=0.505 | P=0.010N* P=0.201N P=0.028N* |
|COCHRAN-ARMITAGE | P=0.643 | P<0.001N** |
|FISHER EXACT | P=0.691N P=0.691N | P=0.181N P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05030 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PROBENECID
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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