TR 395 Rat Pathology Tables
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
Facility: TSI Mason Research
Chemical CAS #: 57-66-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X X X 1 X X X X X 2 X X X X X|
Cyst | X |
Fatty Change, Diffuse | 2 2 2 |
Fatty Change, Focal | 1 1 1 2 1 1 |
Focal Cellular Change | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X |
Necrosis | 1 |
Pigmentation | 2 2 |
Regeneration, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Pigmentation | 2 |
Artery, Thrombosis | 2 |
Fat, Inflammation, Chronic Active | 2 |
Fat, Mineralization | |
Fat, Necrosis | 1 4 |
Fat, Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 3 2 |
Artery, Pigmentation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hypertrophy | |
Acinus, Inflammation, Chronic Active | |
Acinus, Necrosis | 1 1 |
Duct, Inflammation, Chronic Active | 1 2 1 2 |
Duct, Metaplasia, Squamous | 1 1 2 2 2 1 2 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 2 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + M + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 2 2 2 2 2 2 3 2 2|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M M + M + + + M + + M + + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Depletion Lymphoid | 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Angiectasis | 2 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Angiectasis | 2 2 |
Depletion Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2|
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 2 2 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + M +|
Galactocele | X X X X X X X X X X X X X X X X X X X|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Artery, Pigmentation | 2 |
Artery, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hemorrhage | 2 |
Cerebrum, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|
| 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Medulla, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Embolus Tumor | X |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Atypia Cellular | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hydronephrosis | 2 |
Nephropathy | 1 2 2 1 3 1 2 1 2 1 1 1 1 1 1 2 1 2 2 1 1 1|
Cortex, Mineralization | 1 |
Papilla, Mineralization | 1 2 1 2 1 1 1 1 1 1 1 |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoid Nodule, Hyperplasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Lymphoid Nodule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 36 1.5|
Cyst | | 1 |
Fatty Change, Diffuse | 2 2 3 2 2 | 8 2.1|
Fatty Change, Focal | 1 1 1 | 10 1.2|
Focal Cellular Change | X | 1 |
Hepatodiaphragmatic Nodule | X X | 4 |
Mixed Cell Focus | 2 | 5 2.0|
Necrosis | | 1 1.0|
Pigmentation | | 2 2.0|
Regeneration, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Artery, Pigmentation | | 1 2.0|
Artery, Thrombosis | | 1 2.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Mineralization | 1 | 1 1.0|
Fat, Necrosis | 2 3 | 4 2.5|
Fat, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Hyperplasia | | 2 2.5|
Artery, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Hypertrophy | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Necrosis | | 2 1.0|
Duct, Inflammation, Chronic Active | 1 | 5 1.4|
Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 2 | 18 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 2 1.5|
Hyperkeratosis | 2 | 2 2.0|
Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | 32 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia | 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + M M + M + + + + M| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 3 2 3 2 3 3 2 2 2 3| 24 2.3|
Pars Distalis, Cyst | X X X X | 7 |
Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 2 | 15 1.9|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 2 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abscess | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M M + + + + + + + + + + + + M + M + M + M M| 36 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypoplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Angiectasis | 2 2 | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.0|
Pancreatic, Depletion Lymphoid | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.5|
Renal, Angiectasis | 2 | 3 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 2 2.0|
Depletion Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 | 3 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 3 2 1 2 2 1 2 2 3| 38 2.1|
Hemorrhage | | 2 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 2 2 3 | 9 2.2|
Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Galactocele | X X X X X X X X X X X X X X X X X | 36 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Artery, Pigmentation | | 1 2.0|
Artery, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Brain Stem, Hemorrhage | | 1 2.0|
Cerebrum, Necrosis | 3 | 2 2.5|
Medulla, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 2 2 2 2 2 | 6 1.8|
Embolus Tumor | | 1 |
Hemorrhage | 2 | 2 1.5|
Infiltration Cellular, Histiocyte | 2 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 2 | 2 2.0|
Mediastinum, Atypia Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + +| 6 |
__________________________________________________________________________|____________|
Eye | + + + + + + + +| 11 |
Hemorrhage | 2 | 1 2.0|
Lens, Cataract | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 1.0|
Pigmentation | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| |
DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| |
| 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hydronephrosis | | 1 2.0|
Nephropathy | 1 1 2 1 1 2 1 1 1 1 1 2 1 2 2 1 2 1 1 | 41 1.4|
Cortex, Mineralization | 1 1 1 | 4 1.0|
Papilla, Mineralization | 1 1 2 1 1 1 2 | 18 1.2|
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 48 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
Parasite | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 1 1 2|
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + |
Duct, Inflammation, Acute | 1 |
Duct, Metaplasia, Squamous | 2 1 |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Cardiomyopathy | 2 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 1 2 2 3 3 2 3 3 3 2|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + M +|
Hyperplasia | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + |
Angiectasis | 2 2 |
Depletion Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 |
Necrosis | |
Pigmentation | 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Galactocele | X X X X X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Congestion | 2 2 2 2 |
Hemorrhage | 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + + +|
Synechia | |
Lens, Cataract | 2 2 |
Retina, Atrophy | 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
Pigmentation | X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Mineralization | 1 1 |
Papilla, Mineralization | 1 1 1 1 |
Pelvis, Mineralization | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Pigmentation | 1 1 2 2 2 2 2 1 1 1 2 2 2 1 2 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + M + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M +| 8 |
Parasite | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 10 |
Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + +| 11 |
Lymphoid Nodule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + +| 30 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X | 20 |
Clear Cell Focus | X | 1 |
Fatty Change, Diffuse | 2 | 2 2.0|
Fatty Change, Focal | 1 2 2| 7 1.4|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Mixed Cell Focus | | 2 |
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + +| 10 |
Duct, Inflammation, Acute | | 1 1.0|
Duct, Metaplasia, Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + +| 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + +| 9 |
Hyperkeratosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + +| 9 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + +| 9 |
Cardiomyopathy | 2 | 3 2.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + +| 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + +| 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + +| 13 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 2 2 2 2 3 2 2 2 2 2| 24 2.3|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 | 13 1.8|
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 | 13 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + + + + + + + +| 16 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Acute | 3 3 4 | 3 3.3|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + +| 16 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | M + + + +| 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 21 |
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Renal, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocyte | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + +| 20 |
Angiectasis | | 2 2.0|
Depletion Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 23 |
Angiectasis | 2 | 1 2.0|
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 | 6 1.8|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 2 2.5|
Necrosis | 3 | 1 3.0|
Pigmentation | 2 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + +| 10 |
Depletion Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 28 |
Galactocele | X X X X X X X X| 13 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 12 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | M + + + +| 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 10 |
Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + +| 26 |
Congestion | 2 2 2 2 2 2 | 10 2.0|
Hemorrhage | 1 | 2 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + +| 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 4 |
__________________________________________________________________________|____________|
Eye | + + + + + + | 13 |
Synechia | 2 2 | 2 2.0|
Lens, Cataract | 2 2 | 4 2.0|
Retina, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.1|
Pigmentation | | 1 |
Cortex, Mineralization | 1 | 3 1.0|
Papilla, Mineralization | 1 1 1 1 1 1| 10 1.0|
Pelvis, Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 | 30 1.1|
Renal Tubule, Pigmentation | 2 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2| 47 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + +| 8 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + M|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + A|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite | 1 1 1 1 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + A|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | |
Congestion | 2 |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X |
Necrosis | |
Regeneration, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Hemorrhage | |
Fat, Mineralization | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + M|
Acinus, Inflammation, Chronic Active | 1 |
Duct, Inflammation, Chronic Active | |
Duct, Metaplasia, Squamous | 2 1 1 2 1 1 1 1 |
Duct, Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hemorrhage | 1|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + A|
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 3 2 2 2 1 2 3 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Hemorrhage | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + M + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M M M + + + + + + M + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 3 2 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + + +|
Mineralization | 1 |
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic Active | 1 |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Pigmentation | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Decidual Reaction | X |
Hemorrhage | 2 |
Bilateral, Abscess | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Adenomatous| 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 2 |
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 1 2 2 2 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 3 3 2 2 3 3|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +|
Cyst | |
Depletion Lymphoid | 4 |
Hemorrhage | 3 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + + + + M + M + M M|
Galactocele | X X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|
| 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Cerebrum, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 3 |
Congestion | 2 3 |
Edema | 1 2 2 2|
Fibrosis | 2 |
Hemorrhage | 1 1 3 3|
Infiltration Cellular, Histiocyte | 3 2 |
Inflammation, Chronic Active | 2 2 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + + |
Synechia | |
Lens, Cataract | 3 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + |
Pigmentation | 2 |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 |
Cortex, Inflammation, Acute | |
Cortex, Mineralization | 2 1 1 1 1|
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Papilla, Necrosis | |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Pigmentation | 2 1 2 2 1 1 2 2 2 1 2 2 1 1 2 2 2 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + A + + + M + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite | 1 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + M + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + A M + + + + + + + + A +| 44 |
Lymphoid Nodule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 |
Lymphoid Nodule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X | 27 |
Clear Cell Focus | X | 1 |
Congestion | | 1 2.0|
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Mixed Cell Focus | X | 5 |
Necrosis | 4 1| 2 2.5|
Regeneration, Focal | 2 | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 6 |
Fat, Hemorrhage | 2| 1 2.0|
Fat, Mineralization | 2 | 1 2.0|
Fat, Necrosis | 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 2.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Inflammation, Chronic Active | | 1 1.0|
Duct, Inflammation, Chronic Active | 1 | 1 1.0|
Duct, Metaplasia, Squamous | 1 2 1 1 2 | 13 1.3|
Duct, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 2 | 1 2.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 31 2.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + M + + + + + + + +| 45 |
Hyperplasia | 1 1 2 | 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M M + + M + M + + + + + + + M M M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 2 3 2 2 2 2 | 15 2.3|
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia | 2 2 2 2 | 11 2.0|
Pars Intermedia, Angiectasis | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Mineralization | | 1 1.0|
C-Cell, Hyperplasia | 1 | 4 1.0|
Follicular Cell, Hyperplasia | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + M + + + + + + + + + + + + + + + + + M| 45 |
Inflammation, Chronic Active | | 1 1.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 4 |
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Decidual Reaction | | 1 |
Hemorrhage | | 1 2.0|
Bilateral, Abscess | 3 | 1 3.0|
Endometrium, Hyperplasia, Adenomatous| | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 2 | 3 2.3|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Depletion Lymphoid | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 2| 5 2.0|
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 2 2 2 2 2 | 23 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 3 3 2 2 3 3| 15 2.6|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + + + + + + + + + + + + + + +| 46 |
Cyst | X | 1 |
Depletion Lymphoid | | 1 4.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + M + + + M + + M M + + + + M M + + + +| 36 |
Galactocele | X X | 6 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 | 1 3.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Cerebrum, Hemorrhage | 2| 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | | 1 3.0|
Congestion | 3 3 3| 5 2.8|
Edema | 1 2 2 2| 8 1.8|
Fibrosis | | 1 2.0|
Hemorrhage | 1 | 5 1.8|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 6 1.5|
Inflammation, Chronic Active | 2| 3 2.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Synechia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| |
DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| |
| 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Cataract | 2 3 | 3 2.7|
Retina, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 7 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Nephropathy | 1 2 1 1 1 1 1 1 2 2 1 1 1 1 2 | 30 1.2|
Cortex, Inflammation, Acute | 3| 1 3.0|
Cortex, Mineralization | 2 1 1 1 2| 10 1.3|
Papilla, Mineralization | 2 1 1 1 1 1 1 1 1 1 2| 24 1.1|
Papilla, Necrosis | 3| 1 3.0|
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Renal Tubule, Pigmentation | 2 2 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 2 1 1 1| 46 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 2| 1 2.0|
Necrosis | 3| 1 3.0|
Transitional Epithelium, Hyperplasia | 1| 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | 1 |
Congestion | 2 |
Fatty Change, Diffuse | 2 2 3 3 1 |
Fatty Change, Focal | 2 2 1 1 2 2 2 2 1 1 2|
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Necrosis | 2 |
Regeneration, Focal | 2 |
Artery, Inflammation, Chronic Active | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Necrosis, Fibrinoid | 3 3 |
Fat, Necrosis | 4 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 2 3 |
Artery, Necrosis, Fibrinoid | 1 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Inflammation, Chronic Active | 1 |
Artery, Necrosis, Fibrinoid | 2 |
Duct, Inflammation, Chronic Active | 2 1 1 |
Duct, Metaplasia, Squamous | 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 2 |
Necrosis | 2 3 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Artery, Necrosis, Fibrinoid | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 3 1 2 1 2 2|
Thrombosis | |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M M + + + + + + + + M + + + M M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 2 2 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 |
Capsule, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 |
Necrosis | 2 2 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 2 1 |
Artery, Necrosis, Fibrinoid | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 3 2 2 2 2 4 4 1 3 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 |
Renal, Angiectasis | 2 2 |
Renal, Depletion Lymphoid | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 3 |
Necrosis | 2 |
Capsule, Fibrosis | 2 |
Capsule, Inflammation, Chronic Active| 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M M M + M M M + + + + M + + M + M M + +|
Galactocele | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | 2 |
Brain Stem, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|
| 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | 2 |
Congestion | 2 2 |
Edema | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Necrosis, Fibrinoid | 3 |
Bronchiole, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | |
Retina, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 3 2 2 2 1 3 2 1 2 3 2 3 3 2 2 2 2 2 2 2 2|
Artery, Inflammation | 2 |
Cortex, Mineralization | 1 1 |
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Mineralization | 1 1 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| 47 |
Parasite | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + M + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X | 32 |
Clear Cell Focus | | 1 1.0|
Congestion | | 1 2.0|
Fatty Change, Diffuse | 2 1 2| 8 2.0|
Fatty Change, Focal | 2 1 1 1 1 1 1 2 2 2 2 2 2 2 1 1 | 27 1.6|
Hepatodiaphragmatic Nodule | X X| 3 |
Mixed Cell Focus | X | 2 |
Necrosis | | 1 2.0|
Regeneration, Focal | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 35 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Artery, Necrosis, Fibrinoid | | 2 3.0|
Fat, Necrosis | 4 | 4 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 2 2.0|
Acinus, Hyperplasia | 2 2 2 2 2 | 7 2.1|
Artery, Necrosis, Fibrinoid | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Acinus, Inflammation, Chronic Active | | 1 1.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Duct, Inflammation, Chronic Active | | 3 1.3|
Duct, Metaplasia, Squamous | 1 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 2 2.0|
Hyperkeratosis | 3 | 3 2.3|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 2 2.5|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Artery, Necrosis, Fibrinoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Artery, Necrosis, Fibrinoid | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2| 37 2.0|
Thrombosis | X | 1 |
Artery, Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | 2 2 1 2 1 | 9 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| 42 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 2 2 | 9 2.2|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 2 2 3 | 11 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
C-Cell, Hyperplasia | 1 3 1 | 7 1.6|
Capsule, Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 2 2.0|
Necrosis | 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 2 2 | 5 1.8|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 2 1 1 2 2 1 1 2 1 | 17 1.6|
Seminiferous Tubule, Atrophy | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 3 2 2 | 5 2.2|
Renal, Angiectasis | | 2 2.0|
Renal, Depletion Lymphoid | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 2| 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 2 2 2 2 2 2| 27 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Necrosis | 2 | 2 2.0|
Capsule, Fibrosis | | 1 2.0|
Capsule, Inflammation, Chronic Active| | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + + + + + + + + + + + + M M + +| 46 |
Atrophy | 3 | 1 3.0|
Epithelial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M M + M + + M M M M M M + M + M + + +| 26 |
Galactocele | X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis | 4 3 | 4 3.3|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Necrosis, Fibrinoid | | 1 2.0|
Brain Stem, Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchiectasis | | 1 2.0|
Congestion | 2 | 3 2.0|
Edema | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 2 2 2 | 4 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
Artery, Necrosis, Fibrinoid | | 1 3.0|
Bronchiole, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Lens, Cataract | 3 | 1 3.0|
Retina, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1 2 3 2 3 1 2 2 1 2 2| 48 2.0|
Artery, Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| |
| 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Mineralization | | 2 1.0|
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Pelvis, Mineralization | 1 | 4 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 3 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 3 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
Calculus Gross Observation | X X | 2 |
Calculus Micro Observation Only | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
Necrosis | 3|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
Lymphoid Tissue, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Congestion | 3 |
Cyst | X |
Degeneration, Cystic | 1 |
Degeneration | 1 |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 2 2 2 2 1 2 2 1 2|
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 3 |
Artery, Mineralization | 2 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia, Pseudoepitheliomatous | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | 2 |
Duct, Inflammation, Acute | 1 |
Duct, Metaplasia | |
Duct, Metaplasia, Squamous | 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + +|
Acanthosis | 2|
Hyperkeratosis | 2 2|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + +|
Cardiomyopathy | 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 3 4 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Distalis, Pigmentation | 2 |
Pars Intermedia, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
Concretion | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 2 1 1 2 1 1|
Seminiferous Tubule, Atrophy | 2 3 2 2 2 2 2 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Lumbar, Angiectasis | 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mandibular, Angiectasis | 2 |
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 |
Mediastinal, Pigmentation | 2 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 2 2 2 1 2 |
Renal, Angiectasis | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Angiectasis | 3 |
Infiltration Cellular, Histiocyte | 2 2 |
Pigmentation | 2 2 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + +|
Congestion | |
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 3 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|
| 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + +|
Cerebellum, Hemorrhage | 2|
Cerebellum, Necrosis | 2|
Cerebrum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
Congestion | 2 2 1 |
Edema | 1 2 |
Hemorrhage | |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + +|
Congestion | |
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | |
Synechia | 2 |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 2 |
Nephropathy | 1 2 2 3 2 2 2 1 3 2 2 2 1 2 3 2 3 1 1 2 1 1 1|
Cortex, Mineralization | 2 1 2 1 1 1 |
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Mineralization | 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration | 1 |
Renal Tubule, Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Hemorrhage | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 12 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 9 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 8 |
Lymphoid Tissue, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + | 8 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 41 |
Basophilic Focus | X X X X X X X X X X X | 27 |
Clear Cell Focus | X X X X X X | 11 |
Congestion | | 1 3.0|
Cyst | | 1 |
Degeneration, Cystic | | 1 1.0|
Degeneration | | 1 1.0|
Fatty Change, Diffuse | 2 2 2 | 4 2.0|
Fatty Change, Focal | 1 2 1 2 1 | 14 1.6|
Hepatodiaphragmatic Nodule | X X X | 6 |
Mixed Cell Focus | X | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 | 25 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 20 |
Acinus, Atrophy | | 1 2.0|
Acinus, Hyperplasia | 3 | 2 3.0|
Artery, Mineralization | | 1 2.0|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Hyperplasia, Pseudoepitheliomatous | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 16 |
Fibrosis | | 1 2.0|
Hyperplasia | | 1 2.0|
Duct, Inflammation, Acute | | 1 1.0|
Duct, Metaplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Metaplasia, Squamous | 1 | 5 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 12 |
Acanthosis | 3 2 | 3 2.3|
Hyperkeratosis | 2 | 3 2.0|
Hyperplasia, Basal Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 8 |
Cardiomyopathy | 2 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1 2 2 | 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 19 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + +| 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 26 |
Pars Distalis, Angiectasis | 3 2 3 3 2 | 11 2.5|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 2 2 | 6 1.8|
Pars Distalis, Pigmentation | | 1 2.0|
Pars Intermedia, Angiectasis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 12 |
C-Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 15 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 30 |
Concretion | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + +| 44 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 2 2 1 2 1 | 20 1.4|
Seminiferous Tubule, Atrophy | 2 3 2 2 2 3 2 3 3 3 2 2 3| 25 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 27 |
Lumbar, Angiectasis | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 2| 1 2.0|
Lumbar, Pigmentation | 2| 1 2.0|
Mandibular, Angiectasis | | 1 2.0|
Mediastinal, Angiectasis | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Mediastinal, Pigmentation | 2 | 4 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Pancreatic, Pigmentation | 2 | 6 1.8|
Renal, Angiectasis | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.5|
Renal, Pigmentation | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 20 |
Angiectasis | 3 | 2 3.0|
Infiltration Cellular, Histiocyte | 2 2 | 4 2.0|
Pigmentation | 1 2 2 2 | 9 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 19 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | | 1 2.0|
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 9 2.1|
Hemorrhage | 2 | 1 2.0|
Necrosis | 3| 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + | 9 |
Galactocele | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 20 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 3 3 | 3 3.0|
Hyperplasia, Basal Cell | 1 | 1 1.0|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 8 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
Cerebellum, Hemorrhage | | 1 2.0|
Cerebellum, Necrosis | | 1 2.0|
Cerebrum, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 18 |
Congestion | 4 | 4 2.3|
Edema | | 2 1.5|
Hemorrhage | 2 1 2 | 3 1.7|
Inflammation, Acute | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 9 |
Congestion | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| |
| 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
Synechia | | 1 2.0|
Lens, Cataract | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hydronephrosis | | 1 2.0|
Nephropathy | 1 1 1 1 2 2 3 2 1 2 1 2 2 1 1 2 2 2 2 1 2 2 2 3 2| 48 1.8|
Cortex, Mineralization | 1 1 1 | 9 1.2|
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Pelvis, Mineralization | 1 1 1 1 1 | 12 1.0|
Renal Tubule, Degeneration | | 1 1.0|
Renal Tubule, Pigmentation | 1 2 1 2 2 2 1 2 1 3 2 2 1 2 2 2 2 3 3 2 2 2 2| 46 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 10 |
Calculus Gross Observation | X | 2 |
Calculus Micro Observation Only | X | 2 |
Hemorrhage | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperkeratosis | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite | 1 1 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 2 1 1 1 1 2|
Focal Cellular Change | X X |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Necrosis | 2 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | 1 2 |
Fat, Necrosis | 3 |
Fat, Pigmentation | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Duct, Inflammation, Chronic Active | 1 |
Duct, Metaplasia | |
Duct, Metaplasia, Squamous | 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | |
Necrosis | 1|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Mineralization | 2 |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + + M + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Distalis, Necrosis | 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + M +|
Fibrosis | |
Inflammation, Chronic Active | |
Spermatocele | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Necrosis | 2 2 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Congestion | 1 |
Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 2 2 2 1 2 1 1 1|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 3 2 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Infiltration Cellular, | |
Histiocyte | 2 |
Lumbar, Hematopoietic Cell | |
Proliferation | 2 |
Lumbar, Hemorrhage | 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 2 |
Mandibular, Necrosis | |
Mediastinal, Angiectasis | 2 2 2 |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Angiectasis | 2 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 3 2 2 |
Depletion Lymphoid | 2 |
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 1 |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 3 2 1 2 3 3 2 2 2 2 1 3 2|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M M + + M M + + + + M M M + + M + M + M +|
Galactocele | X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | X |
Fibrosis | |
Hyperkeratosis | 3 3 4 |
Hyperplasia, Basal Cell | 1 |
Inflammation, Acute | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
Cerebrum, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 2 |
Edema | 2 2|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 2|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Hemorrhage | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Eye | + + + + + + + + |
Synechia | 2 3 |
Lens, Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|
| 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 2 3 2 |
Sclera, Pigmentation | 1 |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Cyst | X |
Nephropathy | 2 2 2 2 2 3 2 1 1 3 3 1 2 2 2 2 1 2 1 2 2 1 1|
Cortex, Mineralization | 1 |
Papilla, Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Pigmentation | 1 2 3 1 1 1 2 1 1 2 2 1 1 1 1 1 2 1 1 2 2 2 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Parasite | 1 2 | 6 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Parasite | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + A + + + + + + + + + + + + + + +| 47 |
Lymphoid Nodule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 34 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | 1 | 1 1.0|
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 2 1 1 2 1 1 1| 14 1.3|
Focal Cellular Change | | 2 |
Hepatodiaphragmatic Nodule | X | 3 |
Mixed Cell Focus | | 1 |
Necrosis | | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Inflammation, Chronic Active | | 2 1.5|
Fat, Necrosis | | 1 3.0|
Fat, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 1 2.0|
Acinus, Hyperplasia | 2 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Inflammation, Chronic Active | | 1 1.0|
Duct, Metaplasia | 1 | 1 1.0|
Duct, Metaplasia, Squamous | 1 1 1 2 | 10 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 3 1| 6 1.8|
Hyperkeratosis | 1 2 3 1| 5 1.8|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Mineralization | | 1 2.0|
Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 3 2 2 2| 44 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 1 1 2 | 14 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + + M + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 2 4 2 2 | 9 2.3|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 2 | 7 2.0|
Pars Distalis, Necrosis | | 1 3.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 1 3 2 1 1 1 2 | 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
Spermatocele | X | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Necrosis | 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 3 1.7|
Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Congestion | | 1 1.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 1 2 2| 26 1.7|
Seminiferous Tubule, Atrophy | 2 2 2 2 4 2 3 2 2 3 2 2 2 2 2 2 2 2 | 32 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + A + + + + + + + + + + + + + M +| 48 |
Iliac, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Lumbar, Hemorrhage | 2 | 2 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Mandibular, Necrosis | 2 | 1 2.0|
Mediastinal, Angiectasis | 2 | 4 2.0|
Mediastinal, Depletion Lymphoid | 2| 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 2 | 4 2.3|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Angiectasis | 3 | 2 2.5|
Renal, Hemorrhage | | 1 1.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 3 2 1| 11 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + M +| 47 |
Angiectasis | 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 2| 2 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 2 2 1 2 | 18 1.9|
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | | 2 2.5|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 2 2 2 3 2 2 2 2 1 2 3 2| 38 2.1|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 3 2.3|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + + + + + + + + + + + M + M +| 46 |
Atrophy | 3 | 1 3.0|
Depletion Lymphoid | 4| 1 4.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + M M M + M M M + + M + + + M + + + M + M| 27 |
Galactocele | X X | 5 |
Acinus, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Cyst Epithelial Inclusion | | 1 |
Fibrosis | 2 | 1 2.0|
Hyperkeratosis | 2 | 4 3.0|
Hyperplasia, Basal Cell | | 1 1.0|
Inflammation, Acute | 4 | 1 4.0|
Necrosis | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage | 1 | 1 1.0|
Cerebrum, Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| |
| 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | 2 | 1 2.0|
Congestion | 2 2 | 4 2.0|
Edema | 2 | 3 2.0|
Hemorrhage | 1 1 1 1 1| 6 1.2|
Infiltration Cellular, Histiocyte | 1 1 1 | 5 1.2|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 2 3 2 | 7 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + +| 11 |
Synechia | | 2 2.5|
Lens, Cataract | 2 | 3 2.0|
Retina, Atrophy | | 3 2.3|
Sclera, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.0|
Cyst | | 1 |
Nephropathy | 2 2 2 2 3 2 3 2 2 2 2 2 2 3 3 1 2 2 1 1 2 2 1 1| 47 1.9|
Cortex, Mineralization | 1 | 2 1.0|
Papilla, Mineralization | 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1| 35 1.1|
Pelvis, Mineralization | 1 1 1 1 1 | 13 1.0|
Renal Tubule, Mineralization | 1 1 | 3 1.0|
Renal Tubule, Pigmentation | 2 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 46 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + M + + + + + + +| 47 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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