TR 395 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05030 PROBENECID TIME: 13:50:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097
CONT: N01CP9561903 CAS: 57-66-9
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05030 PROBENECID TIME: 13:50:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097
CONT: N01CP9561903 CAS: 57-66-9
PATHOLOGIST: K. MURTHY S. EUSTIS
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 293 447 551 597 610 636 653 658 671 707 |
| 708 720 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 1 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 292 462 499 503 517 582 616 631 650 664 |
| 667 672 694 699 723 |
| CENSORED DEATHS |
| 651 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .4G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 1 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 336 372 457 491 499 513 562 574 580 588 |
| 600 611 652 660 666 670 690 700 703 704 |
| 704 706 707 708 713 723 727 |
| CENSORED DEATHS |
| 695 |
| |
==================================================================================
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 92.0 84.0 74.0 |
| | |
| | |
|.1G/KG | 100.0 100.0 100.0 98.0 98.0 96.0 90.0 88.0 80.0 69.7 |
| | |
| | |
|.4G/KG | 100.0 100.0 100.0 98.0 96.0 94.0 88.0 78.0 72.0 45.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .1G/KG .4G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 69.7% 45.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.003 P=0.722 P=0.006 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.7 591.4 615.4 |
|NATURAL DEATHS (C) | (34.3) (30.1) (21.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.8 686.8 667.4 |
|(STANDARD ERROR) | (11.3) (12.7) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 354 495 510 529 544 579 593 620 635 636 |
| 636 644 649 651 652 652 663 663 675 677 |
| 692 704 720 722 722 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .1G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 85 97 537 551 572 592 593 603 617 691 |
| 699 708 721 722 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .4G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 1 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 94 135 203 216 260 266 270 288 495 512 |
| 526 557 561 592 592 603 605 624 637 639 |
| 649 652 658 670 677 695 698 705 721 722 |
| CENSORED DEATHS |
| 604 |
| |
==================================================================================
PROBENECID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 98.0 98.0 90.0 86.0 64.0 48.0 |
| | |
| | |
|.1G/KG | 98.0 96.0 96.0 96.0 96.0 96.0 94.0 84.0 82.0 70.0 |
| | |
| | |
|.4G/KG | 100.0 96.0 86.0 84.0 84.0 84.0 78.0 65.9 53.6 39.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .1G/KG .4G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 70.0% 39.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.041 P=0.048N P=0.231 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 628.4 567.3 517.4 |
|NATURAL DEATHS (C) | (16.7) (52.7) (35.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 676.7 680.5 599.5 |
|(STANDARD ERROR) | (11.2) (18.7) (25.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROBENECID
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.1G/KG = 2
.4G/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3
| 1 3 3 1 2
| 3 1 2 32 1 1
| 32 2 1 1
P 90 + 3 2 2 1 1
E | 3 3 2 2 1 1
R | 333 2 2 21 1
C | 33 2 21 1
E 80 + 3 3 22 11
N | 3 3 11
T | 3 332 2 111
| 33 2 2
S 70 + 22
U | 3 3
R | 333
V |
I 60 +
V |
A |
L | 33
50 + 3 3
|
| 33
|
40 +
|
---+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+--
0 6 12 18 24 30 36 42 48 54 60 66 72 78 84 90 96 102 108
WEEK
NOTE: 14 obs hidden.
PROBENECID
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.1G/KG = 2
.4G/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 23 1
| 22 3 1 1
| 2 3 3 3 1 1 12 2
| 3 3 1 12 2
90 + 1 21 2
| 33 1 1
P | 3 3 3 1 2 1 1
E | 3 3 2 2
R 80 + 3 3 22
C | 3 3 11 2 2
E | 33 3 11 222
N | 11
T 70 + 3 3 2 2
| 1 1
S | 3 33 1 1
U | 33
R 60 + 33 1 1
V | 33 1 1
I | 1 11
V | 3 33
A 50 + 3 3
L | 1 1
| 33
| 3 3
40 + 33 3
|
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
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