TR 396 Mouse Pathology Tables
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
Facility: International Research and Development Corp.
Chemical CAS #: 79-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|
| 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + + + A +|
Calculus Micro Observation Only | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute, Focal | 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + A + + + + + + +|
Amyloid Deposition | |
Congestion | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Inflammation, Chronic | 2 2 2 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Inflammation, Chronic | 3 |
Duct, Cyst | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Hyperplasia, Focal, Squamous | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Erosion | 1 2 |
Hyperplasia, Cystic | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|
| 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | |
Mineralization | |
Valve, Pigmentation | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Inflammation, Chronic | |
Necrosis | |
Subcapsular, Hyperplasia | 3 3 3 3 3 3 3 3 4 3 3 2 3 3 3 3 2 2 3 2 2 3 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + M + + + + + + + M M M + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + M + + I + + + +|
Cyst | |
Hyperplasia, Focal | 1 4 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic | |
Pigmentation, Cholesterol | 2 |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | X X X X X X X X X X X X|
Cyst, Multiple | X X X X X |
Inflammation, Chronic | 4 |
Mineralization | 2 |
Artery, Amyloid Deposition | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 2 3 3 3 1 2 3 3 1 3 1 4 3 1 1 3 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|
| 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | 2 3 3 1 2 1 2 2 1 1|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation, Acute | |
Mandibular, Abscess | |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Multiple | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | X |
Hematopoietic Cell Proliferation | |
Erythrocytic | 4 |
Hyperplasia, Lymphoid | 3 4 2 4 3 3 |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + M + + + + + + +|
Abscess, Multifocal | |
Atrophy | 1 3 3 |
Cyst | X X X X X |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Hyperplasia | 3 |
Duct, Cyst | |
Duct, Hyperplasia, Atypical | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2|
Granuloma | 1 |
Inflammation, Chronic | 1 |
Parasite External | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|
| 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | |
Mineralization | 2 2 2 2 1 1 3 2 2 2 1 1|
Necrosis, Focal | 2 |
Pigmentation, Cholesterol | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 |
Artery, Mineralization | |
Artery, Media, Hypertrophy | 1 2 1 1|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Exudate | 1 1 1 1 1|
Granuloma | |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Mucosa, Nasopharyngeal Duct, | |
Hyperplasia | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 2 1 1 1 1 1 2 2 1 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Inflammation, Chronic | 1 1 2 2 1 2 1 1 1|
Nephropathy | 2 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|
| 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|
| 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + A + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + A + + + + + + + + + + M + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + A + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + + + + + + + + + + + + A A +|
Amyloid Deposition | |
Congestion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + + + A A +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 2 1 |
Necrosis, Coagulative | 4 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic | 2 1 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Focal, Squamous | 3 1 2 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + A + +|
Erosion | |
Hyperplasia, Cystic | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|
| 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | 2 |
Mineralization | |
Valve, Pigmentation | 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Inflammation, Chronic | 1 |
Necrosis | 2 |
Subcapsular, Hyperplasia | 3 3 3 3 3 3 4 3 3 3 2 3 3 2 3 3 3 2 3 3 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + M M + M M M M + M M + + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | X X X X |
Hyperplasia, Focal | 3 2 3 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute, Focal | |
Inflammation, Chronic | 1 1 |
Pigmentation, Cholesterol | |
Follicle, Cyst | X X X X X X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X |
Cyst, Multiple | X X X X|
Inflammation, Chronic | |
Mineralization | |
Artery, Amyloid Deposition | 2 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 3 3 1 3 4 4 2 4 2 2 4 1 3 4 2 3 4 2 4 1 1 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|
| 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | 1 1 1 2 1 2 1 3 2 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation, Acute | |
Mandibular, Abscess | |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Multiple | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 |
Hyperplasia, Lymphoid | 4 2 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + I + + + M + + + + + + + + + + + + + + M + +|
Abscess, Multifocal | |
Atrophy | 2 2 |
Cyst | X X X |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1|
Acinus, Hyperplasia | |
Duct, Cyst | X X X X |
Duct, Hyperplasia, Atypical | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Granuloma | |
Inflammation, Chronic | 3 2 |
Parasite External | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Inflammation, | |
Granulomatous | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|
| 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 3 |
Mineralization | 2 2 1 2 1 2 1 2 2 1 2 2 2|
Necrosis, Focal | |
Pigmentation, Cholesterol | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Artery, Mineralization | 1 |
Artery, Media, Hypertrophy | 2 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 1 1 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Exudate | 1 2 |
Granuloma | 1 |
Inflammation, Acute | 2 1 1 2 |
Inflammation, Chronic Active | 1 1 |
Mucosa, Nasopharyngeal Duct, | |
Hyperplasia | 3 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 1 1 1 2 1 3 2 3 2 4|
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Olfactory Epithelium, Metaplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Inflammation, Chronic | 1 1 2 1 3 2|
Nephropathy | 2 1 4 1 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|
| 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | 3 3 3|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1| | |
| 1| 1| 9| 5| 9| 1| 0| 0| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + | 55 |
Calculus Micro Observation Only | X | 1 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + A A + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + | 52 |
Amyloid Deposition | 3 | 1 3.0|
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + | 52 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 6 1.5|
Necrosis, Coagulative | | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 23 |
Inflammation, Chronic | 2 | 11 1.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 3 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Duct, Cyst | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | | 1 2.0|
Hyperplasia, Focal, Squamous | 2 | 5 1.8|
Ulcer | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Erosion | 1 | 3 1.3|
Hyperplasia, Cystic | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1| | |
| 1| 1| 9| 5| 9| 1| 0| 0| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + M + + + + + + | 57 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration | 1 2 | 3 1.7|
Mineralization | 1 | 1 1.0|
Valve, Pigmentation | 3 | 8 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | |
Granulocytic | X | 1 |
Inflammation, Chronic | | 1 1.0|
Necrosis | | 1 2.0|
Subcapsular, Hyperplasia | 2 2 2 3 3 2 3 3 2 3 | 59 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 57 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + M + M + | 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 55 |
Cyst | X | 5 |
Hyperplasia, Focal | 1 2 2 3 | 16 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Pigmentation, Cholesterol | | 1 2.0|
Follicle, Cyst | | 9 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1| | |
| 1| 1| 9| 5| 9| 1| 0| 0| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst, Multiple | X X | 11 |
Inflammation, Chronic | 3 | 2 3.5|
Mineralization | | 1 2.0|
Artery, Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic | 2 2 1 2 2 2 3 4 2 | 56 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 1 1 1 2 2 3 | 26 1.7|
Myeloid Cell, Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Iliac, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Iliac, Inflammation, Acute | 2 | 1 2.0|
Mandibular, Abscess | 4 | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Granuloma, Multiple | | 1 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | X X | 3 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 2 3.5|
Hyperplasia, Lymphoid | | 9 3.0|
Hyperplasia, Plasma Cell | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 54 |
Abscess, Multifocal | 4 | 1 4.0|
Atrophy | | 5 2.2|
Cyst | | 8 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + A + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1| | |
| 1| 1| 9| 5| 9| 1| 0| 0| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 | 4 1.0|
Acinus, Hyperplasia | | 1 3.0|
Duct, Cyst | | 4 |
Duct, Hyperplasia, Atypical | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 5 1.8|
Granuloma | | 1 1.0|
Inflammation, Chronic | | 3 2.0|
Parasite External | X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Periosteum, Inflammation, | | |
Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 2.0|
Hemorrhage | | 1 3.0|
Mineralization | 2 2 2 2 | 29 1.8|
Necrosis, Focal | | 1 2.0|
Pigmentation, Cholesterol | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 3 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
Artery, Mineralization | | 1 1.0|
Artery, Media, Hypertrophy | | 6 1.3|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 8 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Congestion | | 2 4.0|
Exudate | 1 1 | 9 1.1|
Granuloma | | 1 1.0|
Inflammation, Acute | | 5 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1| | |
| 1| 1| 9| 5| 9| 1| 0| 0| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 1.0|
Mucosa, Nasopharyngeal Duct, | | |
Hyperplasia | | 1 3.0|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 1 1 3 1 2 2 2 1 | 32 1.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hydronephrosis | 2 | 1 2.0|
Inflammation, Chronic | 2 2 | 17 1.5|
Nephropathy | | 11 1.7|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Inflammation, Chronic | | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|
DAY ON TEST | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|
| 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 1 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 1 1 2 1 1 1|
Inflammation, Chronic Active | 1 |
Necrosis, Coagulative | 2 |
Pigmentation | 3 |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 2 |
Artery, Adventitia, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + I + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal, Squamous | 2 1 1 |
Inflammation, Chronic | 2 |
Ulcer, Multifocal | |
Vein, Dilatation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic | 1 |
Valve, Pigmentation | 2 1 1 1 1 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Pituitary Gland | |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|
DAY ON TEST | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|
| 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cyst | X X X X |
Cyst, Multiple | X X |
Inflammation, Acute | |
Mineralization | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Myelofibrosis | 2 1 2 1 2 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | |
Granulocytic | X |
Hematopoietic Cell Proliferation | |
Erythrocytic | X |
Hyperplasia, Lymphoid | 3 4 4|
Pigmentation | |
__________________________________________________________________________|
Thymus | + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Infiltration Cellular, Mast Cell | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|
DAY ON TEST | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|
| 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Congestion | 2 |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Exudate | 1 1 1 2 1 1 |
Inflammation, Acute | 1 1 1 2 2 1 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|
| 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Gallbladder | A + |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 2 |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Pigmentation | |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Artery, Adventitia, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 1 3 3 3|
Inflammation, Chronic | 3 |
Ulcer, Multifocal | 2 |
Vein, Dilatation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 1 |
Inflammation, Chronic | |
Valve, Pigmentation | 1 1 3 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Pituitary Gland | + + + |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|
| 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cyst | X X X X |
Cyst, Multiple | X |
Inflammation, Acute | |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 4 |
Endometrium, Hyperplasia, Cystic | 4 1 2 2 4 2 2 3 3 3 2 3 2 3 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Myelofibrosis | 1 4 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | X |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Duct, Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Infiltration Cellular, Mast Cell | |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|
| 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Congestion | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1|
Exudate | 1 1 1 1 1 |
Inflammation, Acute | 1 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 2 1 2 1 1 1 1 1 1 2 1 1 3|
Olfactory Epithelium, Metaplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3| | |
| 1| 1| 9| 7| 9| 9| 1| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Gallbladder | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 1 1 1 1 3 | 17 1.2|
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Coagulative | | 1 2.0|
Pigmentation | | 1 3.0|
Hepatocyte, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation, Chronic | 3 | 2 2.5|
Artery, Adventitia, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Cyst | | 1 |
Hyperplasia, Focal, Squamous | 3 | 8 2.1|
Inflammation, Chronic | 2 | 3 2.3|
Ulcer, Multifocal | | 1 2.0|
Vein, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 2 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Valve, Pigmentation | 1 1 | 20 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3| | |
| 1| 1| 9| 7| 9| 9| 1| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 24 |
Cyst | X X X X | 12 |
Cyst, Multiple | X X X | 6 |
Inflammation, Acute | 2 | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 43 |
Inflammation, Acute | 2 | 3 2.7|
Endometrium, Hyperplasia, Cystic | 2 3 1 2 2 2 2 2 3 | 41 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 21 |
Myelofibrosis | 2 2 2 2 | 21 1.9|
__________________________________________________________________________|____________|
Lymph Node | + + | 19 |
Iliac, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 12 |
__________________________________________________________________________|____________|
Spleen | + + + | 25 |
Fibrosis | | 2 1.5|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 |
Hyperplasia, Lymphoid | 4 | 4 3.8|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 3 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 4 |
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3| | |
| 1| 1| 9| 7| 9| 9| 1| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 2 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 1 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 14 |
Congestion | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Concretion | | 1 1.0|
Exudate | 1 1 2 1 | 15 1.1|
Inflammation, Acute | 1 1 | 15 1.1|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 | 3 1.3|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 1 1 1 2 | 32 1.2|
Olfactory Epithelium, Metaplasia | 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 5 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3| | |
| 1| 1| 9| 7| 9| 9| 1| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|
| 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + A + + + + + + M + + M M + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + M + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + I + + +|
Ulcer, Acute | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + A A + + +|
Amyloid Deposition | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + A + + +|
Ulcer, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | |
Granulocytic | X 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 1 2 2 2 3|
Inflammation, Chronic Active | 1 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 3 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Clear Cell Focus | X |
Inflammation, Chronic | 2|
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Mucocele | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2|
Hyperplasia, Diffuse, Squamous | 3 |
Hyperplasia, Focal, Squamous | 2 2 2 1 2 |
Hyperplasia, Multifocal, Squamous | 2 2|
Inflammation, Acute | 1|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|
| 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Ulcer, Multifocal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
Hyperplasia, Atypical, Focal | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
Peridontal Tissue, Cyst | X |
Peridontal Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
Mineralization | |
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Granulocytic | X X |
Hemorrhage | |
Hyperplasia | 2 |
Hypertrophy | 2 3 |
Necrosis | 2 |
Subcapsular, Hyperplasia | 3 3 3 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 2 1 2 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + + M M + M + + + + + M M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Focal | 3 3 2 3 3 2|
Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|
| 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | X X X X X X X X X X |
Cyst, Multiple | X X X X |
Inflammation, Acute | 3 |
Mineralization | 2 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Acute | |
Thrombosis | 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 2 2 2 3 2 3 2 3 3 3 2 2 2|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 2 1 1 2 2 1|
Myeloid Cell, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + M + + + + + + + + + + + + + +|
Iliac, Fibrosis | |
Iliac, Hematopoietic Cell | |
Proliferation Granulocytic | |
Iliac, Inflammation, Acute | 2 |
Iliac, Inflammation, Chronic Active | 4 |
Iliac, Pigmentation | |
Inguinal, Inflammation, Acute | 2 |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Inflammation, Acute | 4 |
Renal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 1 |
Hyperplasia, Lymphoid | 4|
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 4 4 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 |
Hyperplasia, Lymphoid | 3 3 2 2 3 4 3 2|
Hyperplasia, Plasma Cell | |
Inflammation, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|
| 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + M + + + + + + + + + + + M|
Atrophy | |
Cyst | X X X X |
Necrosis | 2 2 |
Pigmentation, Lipofuscin | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hemorrhage | |
Duct, Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Fibrosis | |
Hyperkeratosis | 2 |
Inflammation, Acute, Chronic | 1 |
Inflammation, Chronic | |
Parasite External | |
Ulcer, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Edema | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 2 2 2 1 1 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 |
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic | |
Alveolus, Crystals | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Artery, Media, Hypertrophy | 1 2 1|
Bronchus, Fibrosis | 2 |
Interstitium, Fibrosis, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|
| 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic, | |
Focal | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 2 1 2 2 1 1 1 1 3|
Pleura, Inflammation, Acute, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Exudate | 2 2 2 2 2 1 |
Granuloma | 2 |
Inflammation, Acute | 1 2 1 2 2 1 2 1 1 2 3 2 1 1|
Inflammation, Chronic Active | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 1 2 1 2 1 2 1 2 2 1 2 1 1|
Nasolacrimal Duct, Hyperplasia | 2 |
Olfactory Epithelium, Metaplasia | 2 3 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Metaplasia, Squamous | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2|
Mineralization | |
Nephropathy | 2 1 1 2 1 1 |
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|
| 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + A + M + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + I + + + + + + + + + + + + + +|
Ulcer, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + A A + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + A A + + + + + + + + + + + + +|
Ulcer, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 1 2 2 2 3 |
Inflammation, Chronic Active | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 1|
Clear Cell Focus | |
Inflammation, Chronic | 2 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mucocele | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Hyperplasia, Diffuse, Squamous | |
Hyperplasia, Focal, Squamous | 2 4 2|
Hyperplasia, Multifocal, Squamous | 3 |
Inflammation, Acute | |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|
| 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 2 |
Ulcer, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Atypical, Focal | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
Peridontal Tissue, Cyst | |
Peridontal Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 2 3 |
Mineralization | 1 3 1 |
Coronary Artery, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
Hemorrhage | 2 |
Hyperplasia | |
Hypertrophy | 2 |
Necrosis | 3 |
Subcapsular, Hyperplasia | 3 3 3 3 3 2 3 3 3 3 2 3 3 2 4 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + M + + + + M + M M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + M + I + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal | 3 3 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|
| 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Cyst | X X X X X X X X X X X X |
Cyst, Multiple | X X X X|
Inflammation, Acute | |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Acute | 1 2 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 3 2 3 2 3 3 2 2 3 3 3 2 2 3 2 2|
__________________________________________________________________________|
Vagina | + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 2 3 1 1 1 3 1 |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Fibrosis | 1|
Iliac, Hematopoietic Cell | |
Proliferation Granulocytic | 3|
Iliac, Inflammation, Acute | |
Iliac, Inflammation, Chronic Active | |
Iliac, Pigmentation | 3|
Inguinal, Inflammation, Acute | |
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, Acute | |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 4 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 4 3 |
Hyperplasia, Lymphoid | 2 2 2 4 4 |
Hyperplasia, Plasma Cell | 4 |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|
| 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M M + + + + + + + + + + + + + + M M + + + + + + +|
Atrophy | 3 |
Cyst | X X X|
Necrosis | |
Pigmentation, Lipofuscin | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hemorrhage | 3 |
Duct, Cyst | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | 3 |
Hyperkeratosis | |
Inflammation, Acute, Chronic | |
Inflammation, Chronic | 1 1 |
Parasite External | X |
Ulcer, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Edema | 3 |
Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | 2 2 1 1 2 2 1 2 2 3 2 1|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | 2 |
Alveolus, Crystals | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Media, Hypertrophy | 2 2 1 2 1 1 |
Bronchus, Fibrosis | |
Interstitium, Fibrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|
| 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 1 2 1 1 1 2 2 |
Pleura, Inflammation, Acute, Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Exudate | 1 1 2 1 1 |
Granuloma | |
Inflammation, Acute | 2 2 1 2 1 1 1 1 2 1 1 1|
Inflammation, Chronic Active | 2 2 2 1 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 1 2 1 2 1 1 1 1 2 2 2 2 2 1 2|
Nasolacrimal Duct, Hyperplasia | |
Olfactory Epithelium, Metaplasia | 2 2 1 2 3 1 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 2 3 1|
Mineralization | 1 |
Nephropathy | 1 2 1 1 |
Renal Tubule, Epithelium, | |
Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + I + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 51 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Ulcer, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
Amyloid Deposition | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 54 |
Ulcer, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 4.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 5 2.8|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 | 14 1.9|
Inflammation, Chronic Active | | 1 1.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 8 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 4 2.8|
Clear Cell Focus | | 1 |
Inflammation, Chronic | 2 2 | 5 2.0|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 3 | 3 2.7|
Mucocele | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 4 2.0|
Hyperplasia, Diffuse, Squamous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal, Squamous | 3 1 1 2 | 12 2.0|
Hyperplasia, Multifocal, Squamous | | 3 2.3|
Inflammation, Acute | | 1 1.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic | 1 | 3 1.7|
Ulcer | | 2 2.0|
Ulcer, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 2 1.5|
Hyperplasia, Atypical, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
Peridontal Tissue, Cyst | | 1 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration | | 5 1.6|
Mineralization | | 3 1.7|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | X | 4 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | 1 | 4 2.0|
Necrosis | | 2 2.5|
Subcapsular, Hyperplasia | 2 3 3 3 3 3 3 3 3 4 | 58 2.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + M | 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 57 |
Cyst | | 3 |
Hyperplasia, Focal | 2 | 9 2.7|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.0|
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Abscess | | 3 4.0|
Cyst | X X X | 25 |
Cyst, Multiple | X X | 10 |
Inflammation, Acute | | 1 3.0|
Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Abscess | | 2 4.0|
Inflammation, Acute | | 2 1.5|
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 2 3 2 3 2 2 2 3 2 | 45 2.5|
__________________________________________________________________________|____________|
Vagina | + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 1 2 1 1 2 | 22 1.7|
Myeloid Cell, Hyperplasia | 4 | 4 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 58 |
Iliac, Fibrosis | | 1 1.0|
Iliac, Hematopoietic Cell | | |
Proliferation Granulocytic | | 1 3.0|
Iliac, Inflammation, Acute | | 1 2.0|
Iliac, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Pigmentation | | 1 3.0|
Inguinal, Inflammation, Acute | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Inflammation, Acute | | 1 4.0|
Renal, Inflammation, Acute | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 1.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 | 5 3.8|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 3 3.3|
Hyperplasia, Lymphoid | 2 4 3 3 | 17 2.8|
Hyperplasia, Plasma Cell | | 1 4.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Atrophy | 3 | 2 3.0|
Cyst | X X | 9 |
Necrosis | | 2 2.0|
Pigmentation, Lipofuscin | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 2.0|
Hemorrhage | | 1 3.0|
Duct, Cyst | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Fibrosis | | 1 3.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Acute, Chronic | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Parasite External | X X | 3 |
Ulcer, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Edema | | 1 3.0|
Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Mineralization | 2 2 2 2 | 24 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Hemorrhage | | 2 2.0|
Inflammation, Acute, Focal | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
Alveolus, Crystals | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Artery, Media, Hypertrophy | | 9 1.4|
Bronchus, Fibrosis | | 1 2.0|
Interstitium, Fibrosis, Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 1 2 | 22 1.6|
Pleura, Inflammation, Acute, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Cyst | | 1 |
Exudate | | 11 1.5|
Granuloma | | 1 2.0|
Inflammation, Acute | 1 2 2 2 2 | 31 1.5|
Inflammation, Chronic Active | 2 | 5 1.8|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 1 3 2 1 2 2 2 1 1 | 39 1.5|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Olfactory Epithelium, Metaplasia | 1 2 2 | 17 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3| | |
| 0| 1| 9| 5| 1| 1| 0| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Acute | | 3 2.0|
Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 2 2 2 1 | 21 1.9|
Mineralization | | 1 1.0|
Nephropathy | 1 1 | 12 1.3|
Renal Tubule, Epithelium, | | |
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + | 56 |
Inflammation, Chronic | 2 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|
| 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + A + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | |
Inflammation, Acute | |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Necrosis | |
Bile Duct, Cyst | X |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Hyperplasia, Focal | |
Inflammation, Chronic | 1 |
Necrosis, Multifocal | |
Duct, Cyst | 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 1 |
Erosion | |
Hyperkeratosis | |
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Acute | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|
| 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acute | 2 |
Pulp, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 3 2 1 1 1 1 1 |
Inflammation, Acute, Multifocal | |
Mineralization | 1 |
Epicardium, Inflammation, Chronic | |
Valve, Pigmentation | 1 1 2 1 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | |
Hyperplasia | 3 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 1 4 2 1 2 2 1 3 3 1 2 2 2 4 1 2 2 2 2 2 2 3 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + M + + + + M M + I + + M + M M M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Mineralization | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Penis | + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|
| 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 4 |
Duct, Cyst | 3 X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Mineralization | 1 |
Unilateral, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Inflammation, Acute | |
Inguinal, Pigmentation | |
Mediastinal, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infarct | |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3|
Cyst | X X X |
Ectopic Parathyroid Gland | |
Epithelial Cell, Hyperplasia | 2 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|
| 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M + M M M M I + M + M M M M M +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | |
Fibrosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell, Focal | |
Parasite External | X |
Ulcer | 3 |
Prepuce, Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
Osteoporosis, Focal | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Mineralization | 2 2 1 1 2 1 1 2 1 1 2 3 1 3 2 1 2 3 2 |
Necrosis, Focal | |
Meninges, Perivascular, Inflammation,| |
Chronic | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|
| 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Granuloma | |
Inflammation, Acute | 1 1 |
Inflammation, Chronic | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 2 2 1 3 1 2 2 4 1 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Submucosa, Cyst | X |
Turbinate, Inflammation, Chronic, | |
Multifocal | 1 |
Vomeronasal Organ, Cyst | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Cyst, Multiple | X |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | |
Mineralization | |
Nephropathy | 1 1 1 1 2 1 1 1 2 1 2 2 1 2 2 1 |
Pelvis, Inflammation, Chronic | 3 3 |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + I + + + + + + +|
Calculus Gross Observation | X |
Diverticulum | |
Inflammation, Acute | |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|
| 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A A + + + A + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + A A + + + A + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + + + A + + + A + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + A + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + + A + + + A + + + + + + + A + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 4 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis | 1 1|
Bile Duct, Cyst | |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + A + +|
Atrophy | 2 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | |
Necrosis, Multifocal | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 1 |
Erosion | 1 |
Hyperkeratosis | |
Hyperplasia, Focal, Squamous | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Epithelium, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|
| 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acute | |
Pulp, Inflammation, Acute | 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Acute, Multifocal | |
Mineralization | |
Epicardium, Inflammation, Chronic | 2 |
Valve, Pigmentation | 3 1 1 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
Hypertrophy, Focal | 3 |
Subcapsular, Hyperplasia | 1 3 1 3 2 1 1 4 1 1 1 2 3 2 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + A + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M M M + + + + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + I + +|
Cyst | X |
Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 1 |
Follicle, Cyst | X X X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|
| 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Granulomatous | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + +|
Dilatation | 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 3 |
Mineralization | 1 |
Unilateral, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 4|
Inguinal, Inflammation, Acute | |
Inguinal, Pigmentation | 2 2 |
Mediastinal, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 4 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + M + I + + M + + + + I + M + + + + + M + +|
Atrophy | 3 |
Cyst | X |
Ectopic Parathyroid Gland | X |
Epithelial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|
| 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M + M M M + M M + M M M M + M + M M M|
Hemorrhage, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Acanthosis | |
Fibrosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell, Focal | 2 |
Parasite External | |
Ulcer | |
Prepuce, Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
Osteoporosis, Focal | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Mineralization | 2 2 2 2 2 1 1 2 4 2 2 1 1 2 2 2 3 2|
Necrosis, Focal | |
Meninges, Perivascular, Inflammation,| |
Chronic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|
| 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Granuloma | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 3 1 1 2 1 2 1 1|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Submucosa, Cyst | |
Turbinate, Inflammation, Chronic, | |
Multifocal | |
Vomeronasal Organ, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Cyst, Multiple | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | |
Mineralization | 1 |
Nephropathy | 2 3 1 1 1 1 2 1 1 1 1 1 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + A + + + + + + + + + +|
Calculus Gross Observation | |
Diverticulum | |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus, Multiple | | 1 4.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 1 | 3 1.3|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Necrosis | | 2 1.0|
Bile Duct, Cyst | | 1 |
Hepatocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | | 3 1.3|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Necrosis, Multifocal | | 1 1.0|
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | 1 | 3 1.0|
Erosion | | 1 1.0|
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Focal, Squamous | 2 4 3 | 5 2.6|
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | I + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 1.0|
Inflammation, Acute | 3 | 1 3.0|
Epithelium, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 5 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 2.0|
Pulp, Inflammation, Acute | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration | 3 2 | 21 1.3|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Mineralization | | 1 1.0|
Epicardium, Inflammation, Chronic | | 1 2.0|
Valve, Pigmentation | 2 | 8 1.5|
Ventricle, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Cyst | | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 4 1 | 4 2.5|
Hypertrophy, Focal | | 1 3.0|
Subcapsular, Hyperplasia | 1 3 2 1 3 2 4 2 2 | 54 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + | 56 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M M + + + | 41 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Cyst | X | 2 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | X X | 6 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Penis | + + | 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Abscess | 4 4 | 2 4.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Granulomatous | 2 | 3 3.0|
Duct, Cyst | X X | 5 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 5 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Degeneration | | 3 2.3|
Mineralization | | 2 1.0|
Unilateral, Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 58 |
Inguinal, Hyperplasia, Lymphoid | | 2 3.5|
Inguinal, Hyperplasia, Plasma Cell | 4 3 | 4 3.5|
Inguinal, Inflammation, Acute | 2 | 1 2.0|
Inguinal, Pigmentation | | 2 2.0|
Mediastinal, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I + + + + + + + + + | 56 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 3 2 | 4 3.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + M + | 49 |
Atrophy | | 4 3.3|
Cyst | | 4 |
Ectopic Parathyroid Gland | | 1 |
Epithelial Cell, Hyperplasia | 3 | 9 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M + M | 13 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Acanthosis | 2 | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Basal Cell, Focal | | 1 2.0|
Parasite External | X | 2 |
Ulcer | | 1 3.0|
Prepuce, Inflammation, Acute | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture Healed | | 1 |
Osteoporosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Mineralization | 2 2 1 2 1 1 2 2 | 45 1.8|
Necrosis, Focal | 2 | 1 2.0|
Meninges, Perivascular, Inflammation,| | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | 1 1 1 | 15 1.1|
Granuloma | 2 | 2 1.5|
Inflammation, Acute | | 3 1.0|
Inflammation, Chronic | 1 | 2 1.5|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 3 2 2 1 1 | 23 1.8|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Submucosa, Cyst | | 1 |
Turbinate, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Vomeronasal Organ, Cyst | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Cyst, Multiple | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2| | |
| 7| 0| 9| 6| 0| 0| 9| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 3 |
Inflammation, Acute | 3 | 1 3.0|
Mineralization | 1 | 2 1.0|
Nephropathy | 1 1 1 1 2 1 1 | 36 1.3|
Pelvis, Inflammation, Chronic | | 2 3.0|
Renal Tubule, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Calculus Gross Observation | | 1 |
Diverticulum | 1 | 1 1.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|
| 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Acute | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + A + + + + + A|
Cyst | X |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + A + + + + + +|
Amyloid Deposition | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration | |
Infarct | |
Inflammation, Chronic | 1 |
Necrosis | 3 1 1 |
__________________________________________________________________________|
Mesentery | |
Artery, Perivascular, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cyst | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|
| 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 2 |
Inflammation, Chronic | 1 |
Atrium, Pigmentation | |
Atrium, Thrombosis | X |
Epicardium, Fibrosis | |
Valve, Pigmentation | 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Subcapsular, Hyperplasia | 3 1 2 1 1 2 2 1 2 2 2 2 2 2 1 1 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + M M + + M M + + + M M M M M + M M M + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + I + +|
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Cyst | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + |
Hemorrhage | 2 |
Inflammation, Chronic | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Seminal Vesicle | +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|
| 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 1 1|
Mineralization | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + M + + + +|
Inguinal, Hyperplasia, Plasma Cell | 4 3 |
Inguinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + M + + + +|
Inflammation, Acute | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy, Focal | |
Hematopoietic Cell Proliferation | |
Granulocytic | X X|
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 |
Hyperplasia, Lymphoid | 2 |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M I M + M + I + M M + + + + M|
Atrophy | 3 |
Cyst | X |
Ectopic Parathyroid Gland | X X |
Necrosis | |
Epithelial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M + M M M M M M M M M M M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Acute | |
Inflammation, Chronic | |
Parasite External | X X |
Prepuce, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Melanosis | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|
| 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | 2 2 1 2 2 2 2 1 2 3 2 2 2 2 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 |
Interstitium, Inflammation, Chronic | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 2 1 1 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 1 1 3 1 1 |
Granuloma | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 2 1 3 1 1 1 1 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 1 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
Ulcer, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation, Acute | 1 |
Neovascularization | 3 |
Cornea, Necrosis | 1 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Mineralization | 1 |
Nephropathy | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|
| 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Acute | 4 |
__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + + + + + M + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + A + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + + + A + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + + A + + + + M + + + + + + + + +|
Amyloid Deposition | 1 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + M + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration | |
Infarct | 1 |
Inflammation, Chronic | 1 1 1|
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Artery, Perivascular, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + I + + + + + + + + +|
Cyst | X X |
Erosion | 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|
| 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + M + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + M + + + + + + + + +|
Degeneration | 1 1 1 1 2 1 1 1 1 |
Inflammation, Chronic | 1 |
Atrium, Pigmentation | |
Atrium, Thrombosis | |
Epicardium, Fibrosis | 3 |
Valve, Pigmentation | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
Subcapsular, Hyperplasia | 2 2 2 1 3 2 1 2 3 2 2 2 1 1 1 1 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M M + M M M M M M M M M + + + M M M M M M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Cyst | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + |
Hemorrhage | |
Inflammation, Chronic | 3 |
Duct, Cyst | X X |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|
| 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + I + + + + M + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + I + + + + M + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy, Focal | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + I + + + + + + M M + + + I + + I + +|
Atrophy | |
Cyst | X |
Ectopic Parathyroid Gland | |
Necrosis | 1 |
Epithelial Cell, Hyperplasia | 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M + + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Parasite External | X |
Prepuce, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | |
Melanosis | 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|
| 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | 1 1 2 2 1 1 3 3 1 2 2 1 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
Pleura, Fibrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +|
Exudate | 1 1 2 2 1 1 |
Granuloma | 1 |
Inflammation, Acute | 1 2 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 1 1 1 1 1 3 2 1 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Metaplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +|
Metaplasia, Squamous | 1 |
Ulcer, Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Acute | |
Neovascularization | 1 |
Cornea, Necrosis | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | |
Mineralization | |
Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3| | |
| 1| 9| 9| 1| 1| 4| 0| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Ulcer, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | I + + + + + + + + A | 52 |
Cyst | | 1 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
Amyloid Deposition | | 1 1.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Congestion | 4 | 1 4.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Infarct | 4 | 2 2.5|
Inflammation, Chronic | | 4 1.0|
Necrosis | | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Perivascular, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M | 57 |
Atrophy | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hyperplasia, Focal, Squamous | | 2 2.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3| | |
| 1| 9| 9| 1| 1| 4| 0| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 1 | 3 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Developmental Malformation | X | 1 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Degeneration | 1 1 | 16 1.1|
Inflammation, Chronic | 2 | 3 1.3|
Atrium, Pigmentation | 1 | 1 1.0|
Atrium, Thrombosis | | 1 |
Epicardium, Fibrosis | | 1 3.0|
Valve, Pigmentation | 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Subcapsular, Hyperplasia | 1 1 1 2 1 2 1 | 48 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | I M + M M + + M M + | 19 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3| | |
| 1| 9| 9| 1| 1| 4| 0| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 2 3.0|
Duct, Cyst | X | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 2 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Degeneration | | 4 1.3|
Mineralization | 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 55 |
Inguinal, Hyperplasia, Plasma Cell | | 2 3.5|
Inguinal, Pigmentation | 1 1 1 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy, Focal | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 3 2.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + M + + M M | 42 |
Atrophy | | 1 3.0|
Cyst | X | 3 |
Ectopic Parathyroid Gland | X | 3 |
Necrosis | | 1 1.0|
Epithelial Cell, Hyperplasia | 1 | 7 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M M M + M M | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3| | |
| 1| 9| 9| 1| 1| 4| 0| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.5|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
Parasite External | | 3 |
Prepuce, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Congestion | | 1 1.0|
Melanosis | | 1 1.0|
Mineralization | 3 2 1 1 2 2 | 34 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.3|
Interstitium, Inflammation, Chronic | 2 | 2 1.5|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 6 1.3|
Pleura, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Exudate | 1 2 1 1 1 | 18 1.3|
Granuloma | | 1 1.0|
Inflammation, Acute | 1 | 7 1.1|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | 2 1 | 2 1.5|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 1 2 1 1 1 1 1 | 28 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| | |
DAY ON TEST | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3| | |
| 1| 9| 9| 1| 1| 4| 0| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Metaplasia | | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Metaplasia, Squamous | | 1 1.0|
Ulcer, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Inflammation, Acute | | 1 1.0|
Neovascularization | | 2 2.0|
Cornea, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Cyst | X | 4 |
Mineralization | 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 | 38 1.1|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|
DAY ON TEST | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|
| 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + I + + + + A A + + M + M + + A + A A A A + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A + + + + + A + + A + + A + A + + + +|
Diverticulum | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + A + + + + + + + + A + + M + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | A A + + + + A + + + + + A + + A + A A + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + + + A + + + + + A + + A + A A + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + A + + A + + + + + A + + A + A A A A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + A + + A + + + + + A + + A + A A A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Congestion | |
Hematopoietic Cell Proliferation | |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Necrosis | 2 |
Bile Duct, Cyst | |
Centrilobular, Fatty Change | |
Hepatocyte, Cytomegaly, Diffuse | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 2 2 3 4 |
Hyperplasia, Multifocal, Squamous | 3 2 |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic Active | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | |
Erosion | 1 2 1 1|
Inflammation, Acute | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|
DAY ON TEST | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|
| 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | |
Pulp, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic Active | |
Degeneration | 3 2 2 2 1 2 2 2 2|
Mineralization | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia | 1 |
Hypertrophy, Focal | 1 |
Subcapsular, Hyperplasia | 1 1 2 1 2 1 2 4 1 2 1 1 3 4 1 2 2 1 2 4 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + + + M M + M + M M + + + + + + M M M + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + M + + + + + + +|
Congestion | |
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Fibrosis | |
Inflammation, Chronic | 1 |
Duct, Cyst | 4 X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|
DAY ON TEST | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|
| 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 2|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + M + + M + M + + + + + M +|
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + M + + M + M + + + + + M +|
Congestion, Focal | 1 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 |
Hyperplasia, Lymphoid | 3 3 2 |
Hyperplasia, Plasma Cell | 2 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | 2 |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + M M + M + + + + + + + M M + + M|
Atrophy | 2 |
Cyst | X X X |
Necrosis | |
Epithelial Cell, Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|
DAY ON TEST | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|
| 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Parasite External | X X |
Ulcer | 3 |
Epithelium, Atrophy | 2 |
Hair Follicle, Atrophy | 2 |
Prepuce, Inflammation, Acute | 3 |
Prepuce, Ulcer | 4 2 |
Scrotal, Ulcer, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 2 1 1 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 2 1 1 2|
Hemorrhage | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Chronic | 1 3 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 1 1 2 1 1 1 2 1 1|
Inflammation, Acute | 1 1 1 3 1 2 3 2 3 1 |
Mucosa, Turbinate, Hyperplasia | |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 3 2 1 1 1 1 1 2 1 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 2 2 |
Olfactory Epithelium, Metaplasia | 2 |
Turbinate, Atrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|
DAY ON TEST | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|
| 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Acute | 3 |
Mineralization | |
Nephropathy | 1 2 1 3 1 1 1 1 1 1 1 1|
Capsule, Fibrosis | |
Renal Tubule, Necrosis, Acute | 1 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + I + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Acute | 4 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|
DAY ON TEST | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|
| 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + A + + + + + + + M + + M + + + + A + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + M A + M + A + + + + + + A + + + + A + A + +|
Diverticulum | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | 1 |
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + M + + + + + + + A + + + M + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + A + + + A + + + + + + A + + + + A A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + A A + + + + + A + + + + M A A A A|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + A + + A A + + + + A A A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + A + + + + + + A + + + + A A A + +|
__________________________________________________________________________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Congestion | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Necrosis | 2 3 |
Bile Duct, Cyst | X |
Centrilobular, Fatty Change | 1 |
Hepatocyte, Cytomegaly, Diffuse | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | 2 |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 2 3 |
Hyperplasia, Multifocal, Squamous | 2 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + M + A + +|
Cyst | |
Erosion | 1 1 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|
DAY ON TEST | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|
| 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 1 |
Pulp, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic Active | 4 |
Degeneration | 1 2 3 2 1 1 3|
Mineralization | 1 2 |
Atrium, Thrombosis | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytoplasmic Alteration, Focal | |
Hyperplasia | 1 1 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 1 1 1 1 2 1 2 1 2 2 3 2 1 3 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M M + M + M + M + + M + + M + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + A + + + +|
Follicle, Cyst | X|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + |
Fibrosis | |
Inflammation, Chronic | |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + A + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|
DAY ON TEST | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|
| 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + A + + + +|
Iliac, Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + A A + + +|
Congestion, Focal | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 4 3 3 3 |
Hyperplasia, Lymphoid | 4 2 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + M + + M M + + M M + M + + + M M + + + + + M + M|
Atrophy | |
Cyst | X |
Necrosis | 2 |
Epithelial Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | |
Inflammation, Acute | |
Inflammation, Chronic | 1 2|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|
DAY ON TEST | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|
| 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Parasite External | X X|
Ulcer | 3 3 3|
Epithelium, Atrophy | |
Hair Follicle, Atrophy | |
Prepuce, Inflammation, Acute | 1|
Prepuce, Ulcer | 4 |
Scrotal, Ulcer, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 3 |
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1|
Interstitium, Inflammation, Chronic | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 1 3 2 4 1 1 1 |
Inflammation, Acute | 1 1 1 1 1 2 1 1 1|
Mucosa, Turbinate, Hyperplasia | 2 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | 3 2 1 2 2 2 1 1 2 2|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Metaplasia | 3 |
Turbinate, Atrophy | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|
DAY ON TEST | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|
| 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | 1 |
Mineralization | 1 2 |
Nephropathy | 1 1 1 1 2 2 2 1 2 1 2 |
Capsule, Fibrosis | 2 |
Renal Tubule, Necrosis, Acute | 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + A + + + + + + + + + + + A + A + +|
Ectopic Tissue | |
Inflammation, Acute | 4 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 4| 0| 4| 5| 7| 7| | |
DAY ON TEST | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2| | |
| 3| 9| 1| 5| 5| 8| 7| 4| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A M M + + + | 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + A + + + + | 44 |
Diverticulum | | 1 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + | 56 |
Inflammation, Chronic Active | | 1 1.0|
Parasite Metazoan | X | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + A + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + A + + | 39 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + A A + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + A A + + + + | 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Congestion | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Acute | 4 1 | 2 2.5|
Inflammation, Chronic | | 2 2.5|
Necrosis | 3 4 | 5 2.8|
Bile Duct, Cyst | | 1 |
Centrilobular, Fatty Change | | 1 1.0|
Hepatocyte, Cytomegaly, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + | 57 |
Atrophy | | 4 1.3|
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Cyst | X | 1 |
Hyperplasia, Focal, Squamous | 1 1 | 8 2.3|
Hyperplasia, Multifocal, Squamous | 3 | 5 2.2|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 4| 0| 4| 5| 7| 7| | |
DAY ON TEST | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2| | |
| 3| 9| 1| 5| 5| 8| 7| 4| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | X | 1 |
Erosion | 2 | 8 1.4|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 1.0|
Pulp, Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Abscess, Chronic Active | | 1 4.0|
Degeneration | 2 3 2 | 19 2.0|
Mineralization | | 3 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Basophilic Focus | X | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia | | 3 1.0|
Hypertrophy, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 1 2 1 1 2 1 1 | 49 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Fibrosis | | 2 1.5|
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + M M + | 35 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 56 |
Congestion | | 1 2.0|
Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + | 57 |
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 4| 0| 4| 5| 7| 7| | |
DAY ON TEST | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2| | |
| 3| 9| 1| 5| 5| 8| 7| 4| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 8 |
Fibrosis | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Duct, Cyst | | 4 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + | 57 |
Fibrosis, Focal | | 1 2.0|
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 5 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Degeneration | | 4 1.5|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + A M + + + | 51 |
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A M + + + | 50 |
Congestion, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | 4 | 6 3.3|
Hyperplasia, Lymphoid | | 5 2.8|
Hyperplasia, Plasma Cell | | 3 2.3|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Pigmentation, Hemosiderin | 4 | 2 3.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 4| 0| 4| 5| 7| 7| | |
DAY ON TEST | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2| | |
| 3| 9| 1| 5| 5| 8| 7| 4| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + M M M + M M + + | 38 |
Atrophy | | 1 2.0|
Cyst | | 4 |
Necrosis | | 1 2.0|
Epithelial Cell, Hyperplasia | 1 | 8 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M | 3 |
__________________________________________________________________________|____________|
Skin | I + + + + + + + + + | 59 |
Acanthosis | 2 2 | 2 2.0|
Fibrosis | 3 | 2 2.5|
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic | | 2 1.5|
Parasite External | X X X | 7 |
Ulcer | | 4 3.0|
Epithelium, Atrophy | | 1 2.0|
Hair Follicle, Atrophy | 1 | 2 1.5|
Prepuce, Inflammation, Acute | | 2 2.0|
Prepuce, Ulcer | | 3 3.3|
Scrotal, Ulcer, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture Healed | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 3 2 1 2 1 3 | 28 1.8|
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 4 4 | 11 2.4|
Hemorrhage | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05705-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 12:50:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 4| 0| 4| 5| 7| 7| | |
DAY ON TEST | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2| | |
| 3| 9| 1| 5| 5| 8| 7| 4| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic | | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | 1 1 2 | 22 1.5|
Inflammation, Acute | 1 1 1 2 2 | 24 1.5|
Mucosa, Turbinate, Hyperplasia | | 1 2.0|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 1 2 1 1 | 24 1.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 3 2.3|
Olfactory Epithelium, Metaplasia | | 2 2.5|
Turbinate, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 5 |
Inflammation, Acute | | 2 2.0|
Mineralization | | 2 1.5|
Nephropathy | 1 2 2 2 1 | 28 1.4|
Capsule, Fibrosis | | 1 2.0|
Renal Tubule, Necrosis, Acute | 1 | 6 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + | 54 |
Ectopic Tissue | | 1 |
Inflammation, Acute | | 2 4.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
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