TR 396 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05705 MONOCHLOROACETIC ACID TIME: 19:59:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60231
CONT: 05700-05 CAS: 79-11-8
PATHOLOGIST: D. GOODMAN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05705 MONOCHLOROACETIC ACID TIME: 19:59:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60231
CONT: 05700-05 CAS: 79-11-8
PATHOLOGIST: D. GOODMAN S. EUSTIS
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 2 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 157 455 517 566 627 637 639 652 657 689 |
| 702 716 |
| CENSORED DEATHS |
| 59 361 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 6 6 11 66 66 126 136 434 542 566 |
| 573 581 614 639 659 670 673 674 687 714 |
| 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 5 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 4 63 104 135 149 268 367 424 428 431 |
| 434 443 447 447 467 468 495 497 504 528 |
| 541 545 553 581 588 594 599 623 645 669 |
| 679 695 711 726 |
| CENSORED DEATHS |
| 18 59 62 190 324 |
| |
==================================================================================
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.3 98.3 98.3 98.3 96.6 94.9 93.1 84.5 79.3 |
| | |
| | |
|50 MG/KG | 91.7 88.3 88.3 88.3 88.3 86.7 85.0 80.0 75.0 65.0 |
| | |
| | |
|100MG/KG | 96.6 91.3 89.5 89.5 85.9 71.2 60.3 51.2 47.5 38.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50 MG/KG 100MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 79.3% 65.0% 38.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.096 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 584.5 436.1 466.2 |
|NATURAL DEATHS (C) | (44.7) (61.5) (32.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.8 626.5 530.2 |
|(STANDARD ERROR) | (16.6) (27.9) (29.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 463 511 513 625 627 636 657 671 679 682 |
| 683 687 708 709 717 722 724 |
| CENSORED DEATHS |
| 153 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 253 310 390 503 545 545 587 590 591 614 |
| 636 640 647 651 656 675 697 701 703 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 3 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 100 137 182 182 191 584 640 645 664 672 |
| 717 723 725 |
| CENSORED DEATHS |
| 32 66 182 |
| |
==================================================================================
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.3 94.9 94.9 88.1 71.2 |
| | |
| | |
|50 MG/KG | 100.0 100.0 98.3 96.7 95.0 95.0 90.0 85.0 75.0 66.7 |
| | |
| | |
|100MG/KG | 100.0 96.6 91.3 91.3 91.3 91.3 91.3 89.6 84.3 77.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50 MG/KG 100MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.2% 66.7% 77.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.649N P=0.565 P=0.659N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 647.9 582.2 474.0 |
|NATURAL DEATHS (C) | (19.3) (28.9) (73.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.4 680.1 642.0 |
|(STANDARD ERROR) | (11.7) (13.1) (26.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MONOCHLOROACETIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50 MG/KG = 2
100MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
102.31 +
|12 1
| 3 3 1 1
| 22 3 3 1 1
95.00 + 2 2 3 3 1 1
| 3 3 1 1
| 2 2 3 3 11
| 2 2 3 3 11
87.69 + 2 3 32 1 1
| 32 2 2
P | 22 1 1
E | 22 1 1
R 80.38 + 3 3 2 2 1 1
C | 2 2 1 1
E | 2 2
N | 3 3 22
T 73.08 + 22
| 3 3
S | 2 2
U | 33 2 2
R 65.77 + 3 3 22 2
V | 3 3
I |
V | 33
A 58.46 + 3 3
L | 33
| 3 3
| 33
51.15 + 3 3
| 3 3
| 3 3
| 33
43.85 + 3 3
| 3 3
| 3 3
| 3 3
36.54 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
MONOCHLOROACETIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50 MG/KG = 2
100MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 2 1 1
|
| 3 3 2 2 11
95 + 2 2 1 1
| 2 2
P | 3 3
E | 3 3 11
R 90 + 2 2 13 1
C | 2 2 1 1
E | 33
N | 3 311
T 85 + 2 2 11
| 2 2 33
S | 3 3
U | 22 11 33
R 80 + 22 1 1
V |
I | 3 3
V | 22 11
A 75 + 2 2 11
L | 2 2
|
| 22 1 1
70 +
| 22
|
| 2 2
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.