TR 396 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
MONOCHLOROACETIC ACID
NTP Experiment-Test: 05705-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 21:14:43
Facility: International Research and Development Corp.
Chemical CAS #: 79-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 17 17 17
Early Deaths
Moribund 14 21 13
Dead 2 11 13
Dosing Accident 2 1
Survivors
Terminal Sacrifice 37 19 25
Moribund 1
Animals Examined Microscopically 53 53 53
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ALIMENTARY SYSTEM
Intestine Large, Colon (53) (53) (51)
Intestine Small, Ileum (53) (53) (48)
Liver (53) (53) (53)
Neoplastic Nodule 1 (2%)
Mesentery (4) (2)
Pancreas (53) (53) (51)
Salivary Glands (53) (53) (53)
Stomach, Forestomach (51) (52) (53)
Stomach, Glandular (53) (53) (53)
Tongue (1) (3)
Squamous Cell Papilloma 1 (100%) 1 (33%)
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CARDIOVASCULAR SYSTEM
Heart (53) (53) (53)
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ENDOCRINE SYSTEM
Adrenal Gland, Cortex (53) (53) (52)
Adenoma 1 (2%)
Adrenal Gland, Medulla (52) (52) (53)
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (53) (53) (51)
Carcinoma 1 (2%)
Pituitary Gland (53) (53) (53)
Pars Distalis, Adenoma 26 (49%) 19 (36%) 17 (32%)
Pars Distalis, Carcinoma 2 (4%) 2 (4%)
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NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (53) (52) (52)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 5 (9%) 3 (6%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 2 (4%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (44) (45) (48)
Carcinoma 1 (2%)
Sarcoma 1 (2%)
Ovary (53) (53) (53)
Adenoma 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (53) (53) (53)
Sarcoma Stromal 1 (2%)
Endometrium, Polyp Stromal 1 (2%) 7 (13%) 9 (17%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (53) (53) (53)
Lymph Node (53) (52) (53)
Mediastinal, Sarcoma 1 (2%)
Lymph Node, Mesenteric (52) (52) (53)
Spleen (53) (53) (53)
Thymus (51) (51) (44)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (53) (51)
Carcinoma 2 (4%) 3 (6%) 2 (4%)
Fibroadenoma 26 (49%) 23 (43%) 21 (41%)
Fibroadenoma, Multiple 1 (2%) 1 (2%)
Skin (53) (52) (52)
Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Page 3
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
Brain (53) (53) (53)
Astrocytoma Malignant 2 (4%) 1 (2%)
Carcinoma, Early Invasion, Metastatic,
Pituitary Gland 1 (2%) 1 (2%)
Spinal Cord (1)
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RESPIRATORY SYSTEM
Lung (53) (53) (53)
Nose (52) (53) (48)
Trachea (53) (53) (53)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (53) (52)
Hemangiosarcoma 1 (2%)
Urinary Bladder (52) (52) (49)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(53) *(53) *(53)
Leukemia Mononuclear 16 (30%) 14 (26%) 13 (25%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 45 39
Total Primary Neoplasms 97 79 74
Total Animals with Benign Neoplasms 43 34 36
Total Benign Neoplasms 67 53 55
Total Animals with Malignant Neoplasms 26 24 17
Total Malignant Neoplasms 30 26 19
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 17 17 17
Early Deaths
Dead 8 11 20
Moribund 17 21 15
Accident 1
Dosing Accident 2
Survivors
Terminal Sacrifice 27 21 16
Animals Examined Microscopically 53 53 53
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (52) (52) (53)
Intestine Large, Colon (53) (53) (53)
Intestine Small, Ileum (53) (52) (51)
Carcinoma 1 (2%)
Intestine Small, Jejunum (51) (52) (52)
Carcinoma 1 (2%)
Sarcoma 1 (2%)
Liver (53) (53) (53)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 1 (2%) 1 (2%)
Mesentery (2) (1) (2)
Pancreas (52) (53) (52)
Adenoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Salivary Glands (52) (53) (53)
Stomach (53) (52) (53)
Stomach, Forestomach (53) (52) (53)
Stomach, Glandular (52) (52) (53)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (52) (53) (53)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (52) (51) (53)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (51) (50) (53)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 12 (24%) 11 (22%) 8 (15%)
Bilateral, Pheochromocytoma Benign 5 (10%) 2 (4%)
Islets, Pancreatic (52) (53) (52)
Adenoma 3 (6%) 1 (2%) 1 (2%)
Parathyroid Gland (48) (47) (37)
Adenoma 1 (2%)
Pituitary Gland (53) (52) (53)
Pars Distalis, Adenoma 13 (25%) 6 (12%) 5 (9%)
Thyroid Gland (53) (53) (53)
C-Cell, Adenoma 5 (9%) 2 (4%) 1 (2%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
Follicle, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (52) (50) (52)
Preputial Gland (51) (52) (52)
Squamous Cell Papilloma 1 (2%)
Prostate (48) (52) (53)
Testes (53) (51) (52)
Bilateral, Interstitial Cell, Adenoma 35 (66%) 38 (75%) 39 (75%)
Interstitial Cell, Adenoma 14 (26%) 9 (18%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (52) (52)
Lymph Node (53) (52) (53)
Lymph Node, Mesenteric (53) (52) (53)
Spleen (53) (53) (53)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Thymus (47) (48) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (52) (53)
Adenoma 1 (2%)
Fibroadenoma 3 (6%) 3 (6%) 3 (6%)
Fibroadenoma, Multiple 1 (2%)
Skin (53) (51) (53)
Keratoacanthoma 3 (6%) 3 (6%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Face, Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Trichoepithelioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (53) (52) (52)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (53) (53)
Astrocytoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (53) (53)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Liposarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (52) (53) (53)
Squamous Cell Carcinoma 2 (4%)
Trachea (53) (53) (53)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (53) (53)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (51) (52) (53)
Papilloma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(53) *(53) *(53)
Leukemia Mononuclear 28 (53%) 30 (57%) 20 (38%)
Mesothelioma Benign 1 (2%) 3 (6%) 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 52 52 46
Total Primary Neoplasms 138 123 97
Total Animals with Benign Neoplasms 51 50 46
Total Benign Neoplasms 101 86 69
Total Animals with Malignant Neoplasms 33 33 24
Total Malignant Neoplasms 37 37 28
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 2 5
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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