TR 396 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MONOCHLOROACETIC ACID DATE: 09/18/94
EXPERIMENT: 05705 TEST: 02 TIME: 21:26:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: 05700-05 ROUTE: GAVAGE NTP C#: 60231
PATHOLOGIST: P. HILDEBRANDT CAS: 79-11-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MONOCHLOROACETIC ACID DATE: 09/18/94
EXPERIMENT: 05705 TEST: 02 TIME: 21:26:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 05700-05 ROUTE: GAVAGE NTP C#: 60231
PATHOLOGIST: P. HILDEBRANDT CAS: 79-11-8
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MONOCHLOROACETIC ACID DATE: 09/18/94
EXPERIMENT: 05705 TEST: 02 TIME: 21:26:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 05700-05 ROUTE: GAVAGE NTP C#: 60231
PATHOLOGIST: P. HILDEBRANDT CAS: 79-11-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF MONOCHLOROACETIC ACID
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/51 (33%) 13/50 (26%) 8/53 (15%) | 2/52 (4%) 0/52 (0%) 0/53 (0%) |
|ADJUSTED (b) | 50.4% 46.3% 45.5% | 5.4% 0.0% 0.0% |
|TERMINAL (d) | 11/27 (41%) 7/21 (33%) 7/16 (44%) | 2/37 (5%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 644 577 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.308N P=0.499N P=0.333N | P=0.156N P=0.394N P=0.319N |
|INCIDENTAL TUMOR | P=0.144N P=0.287N P=0.185N | P=0.156N P=0.394N P=0.319N |
|LOGISTIC REGRESSION | P=0.159N P=0.322N P=0.188N | P=0.156N P=0.394N P=0.319N |
|COCHRAN-ARMITAGE | P=0.020N* | P=0.094N |
|FISHER EXACT | P=0.278N P=0.025N* | P=0.248N P=0.243N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/51 (35%) 14/50 (28%) 9/53 (17%) | 2/52 (4%) 0/52 (0%) 0/53 (0%) |
|ADJUSTED (b) | 51.9% 48.0% 48.2% | 5.4% 0.0% 0.0% |
|TERMINAL (d) | 11/27 (41%) 7/21 (33%) 7/16 (44%) | 2/37 (5%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 575 644 577 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.362N P=0.509N P=0.391N | P=0.156N P=0.394N P=0.319N |
|INCIDENTAL TUMOR | P=0.154N P=0.266N P=0.199N | P=0.156N P=0.394N P=0.319N |
|LOGISTIC REGRESSION | P=0.176N P=0.325N P=0.209N | P=0.156N P=0.394N P=0.319N |
|COCHRAN-ARMITAGE | P=0.023N* | P=0.094N |
|FISHER EXACT | P=0.283N P=0.028N* | P=0.248N P=0.243N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/53 (2%) 1/53 (2%) 0/53 (0%) | 2/53 (4%) 1/53 (2%) 0/53 (0%) |
|ADJUSTED (b) | 3.7% 1.9% 0.0% | 5.4% 2.9% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/21 (0%) 0/16 (0%) | 2/37 (5%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 364 --- | 729 (T) 630 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.393N P=0.735 P=0.604N | P=0.219N P=0.678N P=0.319N |
|INCIDENTAL TUMOR | P=0.282N P=0.733 P=0.604N | P=0.179N P=0.536N P=0.319N |
|LOGISTIC REGRESSION | P=0.251N P=0.752N P=0.604N | P=0.176N P=0.576N P=0.319N |
|COCHRAN-ARMITAGE | P=0.332N | P=0.142N |
|FISHER EXACT | P=0.752N P=0.500N | P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/52 (6%) 1/53 (2%) 1/52 (2%) | 0/53 (0%) 0/53 (0%) 0/51 (0%) |
|ADJUSTED (b) | 10.2% 4.8% 5.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 1/21 (5%) 0/16 (0%) | 0/37 (0%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 705 729 (T) 698 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.361N P=0.387N P=0.516N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.296N P=0.345N P=0.419N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.321N P=0.342N P=0.464N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.201N | (e) |
|FISHER EXACT | P=0.302N P=0.309N | (e) (e) |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/52 (6%) 1/53 (2%) 1/52 (2%) | 0/53 (0%) 0/53 (0%) 1/51 (2%) |
|ADJUSTED (b) | 10.2% 4.8% 5.3% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 2/27 (7%) 1/21 (5%) 0/16 (0%) | 0/37 (0%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 705 729 (T) 698 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.361N P=0.387N P=0.516N | P=0.232 (e) P=0.430 |
|INCIDENTAL TUMOR | P=0.296N P=0.345N P=0.419N | P=0.232 (e) P=0.430 |
|LOGISTIC REGRESSION | P=0.321N P=0.342N P=0.464N | P=0.232 (e) P=0.430 |
|COCHRAN-ARMITAGE | P=0.201N | P=0.264 |
|FISHER EXACT | P=0.302N P=0.309N | (e) P=0.490 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/53 (0%) | 2/53 (4%) 3/53 (6%) 2/53 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.7% 12.0% 6.9% |
|TERMINAL (d) | 0/27 (0%) 0/21 (0%) 0/16 (0%) | 1/37 (3%) 1/19 (5%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 565 644 682 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.461 P=0.301 P=0.590 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.564 P=0.603 P=0.670 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.543 P=0.474 P=0.671 |
|COCHRAN-ARMITAGE | (e) | P=0.594 |
|FISHER EXACT | (e) (e) | P=0.500 P=0.691N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/53 (2%) 0/53 (0%) 0/53 (0%) | 2/53 (4%) 3/53 (6%) 2/53 (4%) |
|ADJUSTED (b) | 3.7% 0.0% 0.0% | 4.7% 12.0% 6.9% |
|TERMINAL (d) | 1/27 (4%) 0/21 (0%) 0/16 (0%) | 1/37 (3%) 1/19 (5%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 565 644 682 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.341N P=0.550N P=0.604N | P=0.461 P=0.301 P=0.590 |
|INCIDENTAL TUMOR | P=0.341N P=0.550N P=0.604N | P=0.564 P=0.603 P=0.670 |
|LOGISTIC REGRESSION | P=0.341N P=0.551N P=0.604N | P=0.543 P=0.474 P=0.671 |
|COCHRAN-ARMITAGE | P=0.270N | P=0.594 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.691N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/53 (6%) 3/53 (6%) 4/53 (8%) | 27/53 (51%) 23/53 (43%) 22/53 (42%) |
|ADJUSTED (b) | 11.1% 11.8% 22.6% | 64.1% 66.3% 63.4% |
|TERMINAL (d) | 3/27 (11%) 2/21 (10%) 3/16 (19%) | 22/37 (59%) 9/19 (47%) 14/26 (54%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 633 682 | 626 427 458 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.186 P=0.564 P=0.229 | P=0.323 P=0.070 P=0.367 |
|INCIDENTAL TUMOR | P=0.219 P=0.608 P=0.252 | P=0.441N P=0.529N P=0.546N |
|LOGISTIC REGRESSION | P=0.210 P=0.624 P=0.231 | P=0.439N P=0.559N P=0.545N |
|COCHRAN-ARMITAGE | P=0.421 | P=0.190N |
|FISHER EXACT | P=0.661N P=0.500 | P=0.280N P=0.218N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/53 (8%) 3/53 (6%) 4/53 (8%) | 27/53 (51%) 23/53 (43%) 22/53 (42%) |
|ADJUSTED (b) | 14.8% 11.8% 22.6% | 64.1% 66.3% 63.4% |
|TERMINAL (d) | 4/27 (15%) 2/21 (10%) 3/16 (19%) | 22/37 (59%) 9/19 (47%) 14/26 (54%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 633 682 | 626 427 458 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299 P=0.618N P=0.340 | P=0.323 P=0.070 P=0.367 |
|INCIDENTAL TUMOR | P=0.340 P=0.577N P=0.366 | P=0.441N P=0.529N P=0.546N |
|LOGISTIC REGRESSION | P=0.330 P=0.553N P=0.340 | P=0.439N P=0.559N P=0.545N |
|COCHRAN-ARMITAGE | P=0.576N | P=0.190N |
|FISHER EXACT | P=0.500N P=0.642N | P=0.280N P=0.218N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/53 (8%) 3/53 (6%) 4/53 (8%) | 28/53 (53%) 25/53 (47%) 24/53 (45%) |
|ADJUSTED (b) | 14.8% 11.8% 22.6% | 64.8% 70.9% 67.5% |
|TERMINAL (d) | 4/27 (15%) 2/21 (10%) 3/16 (19%) | 22/37 (59%) 10/19 (53%) 15/26 (58%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 633 682 | 565 427 458 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299 P=0.618N P=0.340 | P=0.243 P=0.043 * P=0.281 |
|INCIDENTAL TUMOR | P=0.340 P=0.577N P=0.366 | P=0.529N P=0.582N P=0.541 |
|LOGISTIC REGRESSION | P=0.330 P=0.553N P=0.340 | P=0.535N P=0.531 P=0.540 |
|COCHRAN-ARMITAGE | P=0.576N | P=0.248N |
|FISHER EXACT | P=0.500N P=0.642N | P=0.349N P=0.280N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Nose |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/52 (4%) 0/53 (0%) 0/53 (0%) | 0/52 (0%) 0/53 (0%) 0/48 (0%) |
|ADJUSTED (b) | 4.4% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/21 (0%) 0/16 (0%) | 0/36 (0%) 0/19 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 350 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.258N P=0.293N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.056N P=0.215N P=0.160N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.051N P=0.214N P=0.131N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.093N | (e) |
|FISHER EXACT | P=0.243N P=0.243N | (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/53 (25%) 6/52 (12%) 5/53 (9%) | 26/53 (49%) 19/53 (36%) 17/53 (32%) |
|ADJUSTED (b) | 39.0% 22.4% 22.6% | 63.2% 61.7% 48.7% |
|TERMINAL (d) | 8/27 (30%) 4/21 (19%) 2/16 (13%) | 22/37 (59%) 9/19 (47%) 9/26 (35%) |
|FIRST INCIDENCE (DAYS) | 621 556 513 | 637 299 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.156N P=0.149N P=0.253N | P=0.405N P=0.197 P=0.409N |
|INCIDENTAL TUMOR | P=0.065N P=0.074N P=0.113N | P=0.139N P=0.460N P=0.191N |
|LOGISTIC REGRESSION | P=0.061N P=0.080N P=0.127N | P=0.144N P=0.330N P=0.201N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.045N* |
|FISHER EXACT | P=0.069N P=0.034N* | P=0.119N P=0.057N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/53 (0%) 0/52 (0%) 0/53 (0%) | 2/53 (4%) 2/53 (4%) 0/53 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.7% 6.5% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/21 (0%) 0/16 (0%) | 1/37 (3%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 565 644 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.247N P=0.556 P=0.297N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.142N P=0.458N P=0.256N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.173N P=0.688N P=0.225N |
|COCHRAN-ARMITAGE | (e) | P=0.176N |
|FISHER EXACT | (e) (e) | P=0.691N P=0.248N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/53 (25%) 6/52 (12%) 5/53 (9%) | 28/53 (53%) 21/53 (40%) 17/53 (32%) |
|ADJUSTED (b) | 39.0% 22.4% 22.6% | 66.3% 64.2% 48.7% |
|TERMINAL (d) | 8/27 (30%) 4/21 (19%) 2/16 (13%) | 23/37 (62%) 9/19 (47%) 9/26 (35%) |
|FIRST INCIDENCE (DAYS) | 621 556 513 | 565 299 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.156N P=0.149N P=0.253N | P=0.302N P=0.172 P=0.290N |
|INCIDENTAL TUMOR | P=0.065N P=0.074N P=0.113N | P=0.070N P=0.365N P=0.103N |
|LOGISTIC REGRESSION | P=0.061N P=0.080N P=0.127N | P=0.071N P=0.312N P=0.104N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.019N* |
|FISHER EXACT | P=0.069N P=0.034N* | P=0.121N P=0.024N* |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/53 (6%) 3/53 (6%) 0/53 (0%) | 0/53 (0%) 0/53 (0%) 1/53 (2%) |
|ADJUSTED (b) | 11.1% 9.1% 0.0% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 3/27 (11%) 0/21 (0%) 0/16 (0%) | 0/37 (0%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 633 --- | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.209N P=0.583 P=0.225N | P=0.232 (e) P=0.430 |
|INCIDENTAL TUMOR | P=0.136N P=0.623N P=0.225N | P=0.232 (e) P=0.430 |
|LOGISTIC REGRESSION | P=0.158N P=0.642 P=0.225N | P=0.232 (e) P=0.430 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.270 |
|FISHER EXACT | P=0.661N P=0.121N | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/53 (6%) 4/53 (8%) 2/53 (4%) | 0/53 (0%) 0/53 (0%) 1/53 (2%) |
|ADJUSTED (b) | 11.1% 13.5% 8.4% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 3/27 (11%) 1/21 (5%) 1/16 (6%) | 0/37 (0%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 633 486 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.530 P=0.405 P=0.667 | P=0.232 (e) P=0.430 |
|INCIDENTAL TUMOR | P=0.481N P=0.522 P=0.610N | P=0.232 (e) P=0.430 |
|LOGISTIC REGRESSION | P=0.519N P=0.469 P=0.603N | P=0.232 (e) P=0.430 |
|COCHRAN-ARMITAGE | P=0.417N | P=0.270 |
|FISHER EXACT | P=0.500 P=0.500N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/53 (4%) 3/53 (6%) 1/53 (2%) | 1/53 (2%) 1/53 (2%) 1/53 (2%) |
|ADJUSTED (b) | 5.3% 12.9% 2.6% | 2.7% 3.6% 3.8% |
|TERMINAL (d) | 0/27 (0%) 2/21 (10%) 0/16 (0%) | 1/37 (3%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 629 718 522 | 729 (T) 652 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.570N P=0.430 P=0.623N | P=0.537 P=0.631 P=0.681 |
|INCIDENTAL TUMOR | P=0.397N P=0.543 P=0.387N | P=0.584 P=0.734 P=0.681 |
|LOGISTIC REGRESSION | P=0.454N P=0.477 P=0.469N | P=0.581 P=0.730 P=0.681 |
|COCHRAN-ARMITAGE | P=0.399N | P=0.639 |
|FISHER EXACT | P=0.500 P=0.500N | P=0.752N P=0.752N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/53 (4%) 3/53 (6%) 1/53 (2%) | 2/53 (4%) 2/53 (4%) 1/53 (2%) |
|ADJUSTED (b) | 5.3% 12.9% 2.6% | 4.8% 7.8% 3.8% |
|TERMINAL (d) | 0/27 (0%) 2/21 (10%) 0/16 (0%) | 1/37 (3%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 629 718 522 | 626 652 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.570N P=0.430 P=0.623N | P=0.508N P=0.508 P=0.612N |
|INCIDENTAL TUMOR | P=0.397N P=0.543 P=0.387N | P=0.404N P=0.599N P=0.560N |
|LOGISTIC REGRESSION | P=0.454N P=0.477 P=0.469N | P=0.438N P=0.675 P=0.550N |
|COCHRAN-ARMITAGE | P=0.399N | P=0.390N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.691N P=0.500N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 49/53 (92%) 47/51 (92%) 45/52 (87%) | |
|ADJUSTED (b) | 98.0% 100.0% 100.0% | |
|TERMINAL (d) | 26/27 (96%) 21/21 (100%) 16/16 (100%) | |
|FIRST INCIDENCE (DAYS) | 436 427 450 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013 * P=0.248 P=0.018 * | |
|INCIDENTAL TUMOR | P=0.406 P=0.542N P=0.598 | |
|LOGISTIC REGRESSION | P=0.323 P=0.590N P=0.513 | |
|COCHRAN-ARMITAGE | P=0.195N | |
|FISHER EXACT | P=0.620N P=0.252N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/53 (9%) 2/53 (4%) 1/53 (2%) | 6/53 (11%) 3/52 (6%) 3/52 (6%) |
|ADJUSTED (b) | 16.6% 9.5% 3.8% | 14.1% 10.2% 11.5% |
|TERMINAL (d) | 4/27 (15%) 2/21 (10%) 0/16 (0%) | 3/37 (8%) 1/19 (5%) 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 512 729 (T) 653 | 558 568 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.150N P=0.309N P=0.233N | P=0.344N P=0.497N P=0.420N |
|INCIDENTAL TUMOR | P=0.102N P=0.344N P=0.155N | P=0.248N P=0.135N P=0.329N |
|LOGISTIC REGRESSION | P=0.099N P=0.235N P=0.153N | P=0.235N P=0.264N P=0.319N |
|COCHRAN-ARMITAGE | P=0.060N | P=0.187N |
|FISHER EXACT | P=0.219N P=0.103N | P=0.254N P=0.254N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/53 (4%) 1/53 (2%) 0/53 (0%) | 2/53 (4%) 0/52 (0%) 2/52 (4%) |
|ADJUSTED (b) | 7.4% 4.8% 0.0% | 5.4% 0.0% 6.7% |
|TERMINAL (d) | 2/27 (7%) 1/21 (5%) 0/16 (0%) | 2/37 (5%) 0/19 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | 729 (T) --- 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.588N P=0.359N | P=0.503 P=0.394N P=0.573 |
|INCIDENTAL TUMOR | P=0.236N P=0.588N P=0.359N | P=0.541 P=0.394N P=0.621 |
|LOGISTIC REGRESSION | P=0.236N P=0.588N P=0.359N | P=0.542 P=0.394N P=0.618 |
|COCHRAN-ARMITAGE | P=0.142N | P=0.616 |
|FISHER EXACT | P=0.500N P=0.248N | P=0.252N P=0.684 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/53 (13%) 3/53 (6%) 1/53 (2%) | 8/53 (15%) 3/52 (6%) 5/52 (10%) |
|ADJUSTED (b) | 23.8% 14.3% 3.8% | 19.2% 10.2% 17.9% |
|TERMINAL (d) | 6/27 (22%) 3/21 (14%) 0/16 (0%) | 5/37 (14%) 1/19 (5%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | 512 729 (T) 653 | 558 568 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067N P=0.258N P=0.112N | P=0.419N P=0.329N P=0.507N |
|INCIDENTAL TUMOR | P=0.045N* P=0.286N P=0.071N | P=0.316N P=0.071N P=0.399N |
|LOGISTIC REGRESSION | P=0.043N* P=0.185N P=0.070N | P=0.299N P=0.130N P=0.391N |
|COCHRAN-ARMITAGE | P=0.018N* | P=0.220N |
|FISHER EXACT | P=0.160N P=0.030N* | P=0.107N P=0.290N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/53 (2%) 7/53 (13%) 9/53 (17%) |
|ADJUSTED (b) | | 2.7% 26.6% 26.8% |
|TERMINAL (d) | | 1/37 (3%) 3/19 (16%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 504 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.004 ** P=0.005 ** P=0.003 ** |
|INCIDENTAL TUMOR | | P=0.007 ** P=0.024 * P=0.009 ** |
|LOGISTIC REGRESSION | | P=0.006 ** P=0.024 * P=0.006 ** |
|COCHRAN-ARMITAGE | | P=0.009 ** |
|FISHER EXACT | | P=0.030 * P=0.008 ** |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/53 (4%) 7/53 (13%) 9/53 (17%) |
|ADJUSTED (b) | | 5.1% 26.6% 26.8% |
|TERMINAL (d) | | 1/37 (3%) 3/19 (16%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 691 504 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.009 ** P=0.015 * P=0.010 ** |
|INCIDENTAL TUMOR | | P=0.020 * P=0.074 P=0.027 * |
|LOGISTIC REGRESSION | | P=0.015 * P=0.062 P=0.018 * |
|COCHRAN-ARMITAGE | | P=0.023 * |
|FISHER EXACT | | P=0.080 P=0.026 * |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/53 (53%) 30/53 (57%) 20/53 (38%) | 16/53 (30%) 14/53 (26%) 13/53 (25%) |
|ADJUSTED (b) | 65.5% 75.6% 63.7% | 33.5% 42.2% 36.2% |
|TERMINAL (d) | 13/27 (48%) 12/21 (57%) 6/16 (38%) | 6/37 (16%) 4/19 (21%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 436 448 492 | 520 504 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311 P=0.202 P=0.391 | P=0.447 P=0.254 P=0.501 |
|INCIDENTAL TUMOR | P=0.198N P=0.457 P=0.191N | P=0.257N P=0.146N P=0.247N |
|LOGISTIC REGRESSION | P=0.193N P=0.383 P=0.175N | P=0.344N P=0.150N P=0.384N |
|COCHRAN-ARMITAGE | P=0.073N | P=0.292N |
|FISHER EXACT | P=0.423 P=0.086N | P=0.415N P=0.332N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/53 (4%) 3/53 (6%) 1/53 (2%) | 0/53 (0%) 0/53 (0%) 0/53 (0%) |
|ADJUSTED (b) | 6.2% 12.0% 2.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 2/21 (10%) 0/16 (0%) | 0/37 (0%) 0/19 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 656 647 450 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563N P=0.410 P=0.617N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.447N P=0.472 P=0.476N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.425N P=0.479 P=0.464N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.399N | (e) |
|FISHER EXACT | P=0.500 P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 51/53 (96%) 50/53 (94%) 46/53 (87%) | 43/53 (81%) 34/53 (64%) 36/53 (68%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.4% 85.8% 87.6% |
|TERMINAL (d) | 27/27 (100%) 21/21 (100%) 16/16 (100%) | 34/37 (92%) 14/19 (74%) 21/26 (81%) |
|FIRST INCIDENCE (DAYS) | 436 427 450 | 558 299 458 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.204 P=0.021 * | P=0.204 P=0.045 * P=0.218 |
|INCIDENTAL TUMOR | P=0.398N P=0.398N P=0.464N | P=0.382N P=0.230N P=0.527N |
|LOGISTIC REGRESSION | P=0.398N P=0.398N P=0.464N | P=0.357N P=0.168N P=0.526N |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.082N |
|FISHER EXACT | P=0.500N P=0.080N | P=0.040N* P=0.090N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 33/53 (62%) 33/53 (62%) 24/53 (45%) | 26/53 (49%) 24/53 (45%) 17/53 (32%) |
|ADJUSTED (b) | 72.3% 79.2% 69.8% | 51.6% 65.7% 47.0% |
|TERMINAL (d) | 15/27 (56%) 13/21 (62%) 7/16 (44%) | 13/37 (35%) 8/19 (42%) 8/26 (31%) |
|FIRST INCIDENCE (DAYS) | 350 364 486 | 215 504 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.317 P=0.283 P=0.381 | P=0.398N P=0.094 P=0.372N |
|INCIDENTAL TUMOR | P=0.080N P=0.557 P=0.091N | P=0.052N P=0.168N P=0.045N* |
|LOGISTIC REGRESSION | P=0.107N P=0.573 P=0.078N | P=0.072N P=0.265N P=0.068N |
|COCHRAN-ARMITAGE | P=0.048N* | P=0.047N* |
|FISHER EXACT | P=0.579N P=0.059N | P=0.423N P=0.057N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05705 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MONOCHLOROACETIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 15 MG/KG 30 MG/KG | CONTROL 15 MG/KG 30 MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 52/53 (98%) 52/53 (98%) 46/53 (87%) | 50/53 (94%) 45/53 (85%) 39/53 (74%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 96.2% 93.6% 92.8% |
|TERMINAL (d) | 27/27 (100%) 21/21 (100%) 16/16 (100%) | 35/37 (95%) 16/19 (84%) 23/26 (88%) |
|FIRST INCIDENCE (DAYS) | 350 364 450 | 215 299 458 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024 * P=0.174 P=0.030 * | P=0.332 P=0.007 ** P=0.401 |
|INCIDENTAL TUMOR | P=0.065N P=0.807 P=0.156N | P=0.022N* P=0.091N P=0.041N* |
|LOGISTIC REGRESSION | P=0.010N** P=0.807 P=0.092N | P=0.020N* P=0.253N P=0.047N* |
|COCHRAN-ARMITAGE | P=0.010N* | P=0.003N** |
|FISHER EXACT | P=0.752N P=0.030N* | P=0.101N P=0.003N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).