TR 396 Rat Pathology Tables
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
Facility: International Research and Development Corp.
Chemical CAS #: 79-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|
| 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Angiectasis | |
Basophilic Focus | X X X X X X X X |
Basophilic Focus, Multiple | X X X X X X |
Congestion | 1 |
Cytoplasmic Alteration, Focal | 3 2 |
Degeneration, Fatty | |
Hemorrhage, Focal | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Focal | |
Inflammation, Granulomatous, | |
Multifocal | 1 2 1 1 |
Necrosis, Acute, Coagulative, | |
Multifocal | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 1 1 |
Hepatocyte, Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic, Multifocal | 2 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 3 2 2 1|
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Duct, Inflammation, Chronic | 1 |
Duct, Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + +|
Inflammation, Acute | 3|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|
| 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia | 2 2 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Necrosis, Acute | |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 1 2 1 1 2 1 1 1 1 2 1 1|
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 2 |
Hyperplasia, Focal | 2 1 1 2 |
Hypertrophy, Focal | 2 2 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Focal | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + + M + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 3 2 1|
Pars Distalis, Hyperplasia | 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M M + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|
| 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | 2 |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Acute | |
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypoplasia | |
Myelofibrosis | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + +|
Edema | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + + + + +|
Autolysis | 1 |
Cyst | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 3 2 |
Hyperplasia | 1 3 3 1 2 2 1|
Duct, Ectasia | 2 1 3 3 1 3 1 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Third Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|
| 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | |
Inflammation, Chronic | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3|
Interstitium, Infiltration Cellular, | |
Multifocal | 3 |
Perivascular, Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | X X |
Inflammation, Chronic, Focal | |
Mucosa, Inflammation, Chronic Active | 3 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 |
Nephropathy | 1 1 2 2 3 1 3 3 1 2 3 2 2 1 1 3 1 3|
Renal Tubule, Epithelium, | |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only, | |
Multifocal | |
Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|
DAY ON TEST | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|
| 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | |
Basophilic Focus | X X 1 X |
Basophilic Focus, Multiple | X X X X X X |
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Fatty | 3 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Focal | 2 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 2 1 2 2 2 2 |
Necrosis, Acute, Coagulative, | |
Multifocal | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1 1 |
Hepatocyte, Hypertrophy, Focal | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic, Multifocal | |
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 1 1 1 1 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Duct, Inflammation, Chronic | 1 |
Duct, Inflammation, Chronic Active | 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|
DAY ON TEST | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|
| 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis, Acute | 1|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 2 1 1 1 1 1 1 1 |
Atrium Left, Thrombosis | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 1 1 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | 1 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + M + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | |
Pars Distalis, Angiectasis | 3 3 2 1|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + I + I + I + + + + +|
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 1 3 1 1 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|
DAY ON TEST | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|
| 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Follicle, Cyst | 3|
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Acute | 2 3 |
Inflammation, Chronic | 3 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypoplasia | 2 |
Myelofibrosis | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Fibrosis | 3|
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 2 1 2 1 3 2 |
Duct, Ectasia | 2 1 3 3 3 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Third Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|
DAY ON TEST | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|
| 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Inflammation, Chronic | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Interstitium, Infiltration Cellular, | |
Multifocal | |
Perivascular, Inflammation, Chronic | 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + M + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic, Focal | 2 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1|
Nephropathy | 1 2 3 2 1 1 3 1 2 2 2 1 2 1 1|
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + +|
Calculus Micro Observation Only, | |
Multifocal | X |
Hyperplasia, Papillary | 4 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| | |
DAY ON TEST | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3| | |
| 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + | 53 |
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 52 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 53 |
Angiectasis, Focal | | 1 2.0|
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X | 16 1.0|
Basophilic Focus, Multiple | X X X X X X X X X | 21 |
Congestion | | 1 1.0|
Cytoplasmic Alteration, Focal | 3 2 1 | 6 2.2|
Degeneration, Fatty | | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Acute, Focal | | 2 1.5|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 2 2 2 2 1 1 1 2 | 21 1.7|
Necrosis, Acute, Coagulative, | | |
Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 | 7 1.1|
Hepatocyte, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Chronic, Multifocal | | 1 2.0|
Fat, Necrosis, Focal | 3 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 53 |
Atrophy, Focal | 1 1 1 1 1 1 | 19 1.3|
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 53 |
Hemorrhage | | 1 3.0|
Duct, Inflammation, Chronic | 2 2 1 | 5 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| | |
DAY ON TEST | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3| | |
| 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Inflammation, Chronic Active | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 51 |
Inflammation, Acute | 2 | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
Epithelium, Hyperplasia | 2 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 2 1 2 1 1 2 1 1 1 1 2 2 2 1 | 41 1.4|
Atrium Left, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 53 |
Congestion | | 1 2.0|
Ectasia | 2 | 2 2.0|
Hyperplasia, Focal | 1 1 2 2 | 10 1.4|
Hypertrophy, Focal | 2 1 1 1 | 9 1.4|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 2 | 11 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + | 52 |
Hyperplasia, Focal | 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + M + + + + + | 43 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 53 |
Pigmentation, Focal | 1 | 1 1.0|
Pars Distalis, Angiectasis | 2 2 | 6 2.2|
Pars Distalis, Cyst | 3 3 2 2 3 | 10 2.3|
Pars Distalis, Hyperplasia | 3 2 | 9 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 53 |
C-Cell, Hyperplasia | 2 2 1 1 1 1 1 1 | 20 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| | |
DAY ON TEST | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3| | |
| 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + M + + + | 44 |
Inflammation, Acute | 3 1 | 5 1.8|
Inflammation, Chronic | 1 1 1 1 | 11 1.2|
Inflammation, Chronic Active | 1 | 6 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 53 |
Hemorrhage | | 1 2.0|
Follicle, Cyst | 3 2 3 3 | 6 2.7|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + | 53 |
Dilatation | | 2 3.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia | 2 | 1 2.0|
Hypoplasia | | 1 2.0|
Myelofibrosis | 2 | 2 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 52 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 53 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 3.0|
Pigmentation | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + | 51 |
Autolysis | | 1 1.0|
Cyst | 2 | 2 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 53 |
Galactocele | 3 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| | |
DAY ON TEST | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3| | |
| 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 3 1 2 2 1 2 1 2 | 23 1.8|
Duct, Ectasia | 1 3 2 2 1 1 2 2 | 24 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 53 |
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 53 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 53 |
Hydrocephalus | | 1 2.0|
Third Ventricle, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 53 |
Congestion | | 1 1.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.0|
Interstitium, Infiltration Cellular, | | |
Multifocal | | 1 3.0|
Perivascular, Inflammation, Chronic | 1 1 1 1 1 | 14 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 52 |
Fungus | X X | 5 |
Inflammation, Chronic, Focal | | 1 2.0|
Mucosa, Inflammation, Chronic Active | 2 2 | 5 2.4|
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 2 | 4 1.8|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens, Cataract | 3 3 | 2 3.0|
Retina, Degeneration | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| | |
DAY ON TEST | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3| | |
| 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 53 |
Mineralization, Multifocal | 1 1 | 9 1.0|
Nephropathy | 3 2 1 2 2 1 1 1 2 3 3 1 1 | 46 1.8|
Renal Tubule, Epithelium, | | |
Pigmentation | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 52 |
Calculus Micro Observation Only, | | |
Multifocal | | 1 |
Hyperplasia, Papillary | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|
DAY ON TEST | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|
| 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Autolysis | 2 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Congestion | |
Edema | |
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Basophilic Focus, Multiple | X X X X X |
Congestion | |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty | 4 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1|
Necrosis, Acute, Focal | |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 1|
Cytoplasmic Alteration, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 3 |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|
DAY ON TEST | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|
| 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis, Acute | 1 1 |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1|
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 |
Mineralization | |
Necrosis, Acute, Focal | |
Thrombosis | 1 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 1 |
Bilateral, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + M + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 2 1 2 1 2|
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M + + + + M + M|
Hyperplasia | |
Hyperplasia, Squamous | |
Inflammation, Acute | 2 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|
DAY ON TEST | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|
| 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | 3 2|
Myeloid Cell, Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Renal, Congestion | 2 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 4 2 |
Inflammation, Focal, Granulomatous | |
Necrosis, Focal | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Inflammation, Acute | 3 |
Duct, Ectasia | 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Face, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|
DAY ON TEST | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|
| 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage, Focal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | |
Hemorrhage | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Autolysis | 2 2 1|
Foreign Body | |
Fungus | |
Hemorrhage | 3 |
Mucosa, Inflammation, Acute | 1 1 |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Sinus, Inflammation, Acute | 2 |
Vein, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 3 |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 3 1 |
Hemorrhage | 2 |
Mineralization, Focal | |
Mineralization, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|
DAY ON TEST | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|
| 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 2 1 2 2 1 3 3 3 1 1|
Cortex, Renal Tubule, Necrosis, Focal| |
Renal Tubule, Epithelium, | |
Pigmentation | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|
DAY ON TEST | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|
| 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 2 |
Edema | |
Hyperplasia, Lymphoid | 2 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X X X X X |
Congestion | 2 3 |
Cytoplasmic Alteration, Focal | 1 |
Degeneration, Fatty | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous, | |
Multifocal | 1 2 3 2 2 2 2 1|
Necrosis, Acute, Focal | 1 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 2 2 1 |
Cytoplasmic Alteration, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|
DAY ON TEST | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|
| 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis, Acute | 1 1 |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 2 2 2 1 1 1|
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Focal | 1 2 2 |
Hypertrophy, Focal | 2 |
Mineralization | 4 |
Necrosis, Acute, Focal | |
Thrombosis | |
Vacuolization Cytoplasmic, Diffuse | 2 2 |
Vacuolization Cytoplasmic, Focal | |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Squamous | 2 |
Inflammation, Acute | 2 2 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|
DAY ON TEST | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|
| 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 3 1|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 |
Endometrium, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Vagina | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M +|
Renal, Congestion | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Hematopoietic Cell Proliferation | |
Granulocytic | 1 |
Inflammation, Focal, Granulomatous | 1 |
Necrosis, Focal | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
Inflammation, Acute | |
Duct, Ectasia | 2 2 2 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Face, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|
DAY ON TEST | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|
| 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage, Focal | |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Fibrosis, Focal | 1 |
Hemorrhage | 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Foreign Body | 2 |
Fungus | |
Hemorrhage | |
Mucosa, Inflammation, Acute | 2 1 2 |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Sinus, Inflammation, Acute | |
Vein, Thrombosis | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
Bilateral, Lens, Cataract | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 2|
Congestion | 2 |
Hemorrhage | |
Mineralization, Focal | 1 |
Mineralization, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|
DAY ON TEST | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|
| 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 3 2 1 1 1 4 1 2 1 1 2 2 2 2 2|
Cortex, Renal Tubule, Necrosis, Focal| 2 |
Renal Tubule, Epithelium, | |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7| | |
DAY ON TEST | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3| | |
| 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 1 | 3 1.7|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 53 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + | 51 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 3 3 | 3 3.3|
Congestion | 2 | 2 2.0|
Edema | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 52 |
Autolysis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 53 |
Basophilic Focus | X | 6 |
Basophilic Focus, Multiple | X X X X X | 17 |
Congestion | | 2 2.5|
Cytoplasmic Alteration, Focal | 2 1 | 3 1.3|
Degeneration, Fatty | | 1 4.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Granulomatous, | | |
Multifocal | 2 2 2 2 2 1 1 | 19 1.6|
Necrosis, Acute, Focal | 1 | 2 1.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 53 |
Atrophy, Focal | 1 1 1 1 1 2 | 15 1.3|
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7| | |
DAY ON TEST | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3| | |
| 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + | 52 |
Inflammation, Acute | 2 | 3 2.3|
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | 1 | 1 1.0|
Necrosis, Acute | | 4 1.0|
Pigmentation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 2 1 | 31 1.2|
Atrium Left, Thrombosis | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 53 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Focal | 1 2 2 1 | 8 1.6|
Hypertrophy, Focal | 1 1 | 4 1.3|
Mineralization | | 1 4.0|
Necrosis, Acute, Focal | 2 | 1 2.0|
Thrombosis | | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 1 1 1 2 2 | 9 1.2|
Bilateral, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + M + + + + M + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 53 |
Pars Distalis, Angiectasis | 2 2 | 4 2.3|
Pars Distalis, Cyst | 3 | 4 2.3|
Pars Distalis, Hyperplasia | 2 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 52 |
Ultimobranchial Cyst | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7| | |
DAY ON TEST | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3| | |
| 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + M + + + + + | 45 |
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Acute | 2 | 8 1.8|
Inflammation, Chronic | 2 1 | 6 1.5|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 53 |
Follicle, Cyst | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 53 |
Dilatation | 2 | 5 2.0|
Endometrium, Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia | 2 | 1 2.0|
Myelofibrosis | | 3 2.3|
Myeloid Cell, Hyperplasia | 1 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 52 |
Renal, Congestion | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 52 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 53 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 2 | 5 2.4|
Inflammation, Focal, Granulomatous | | 1 1.0|
Necrosis, Focal | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7| | |
DAY ON TEST | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3| | |
| 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Cystic | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Duct, Ectasia | 2 | 11 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + I + + + + + + | 52 |
Face, Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 53 |
Hemorrhage, Focal | 1 | 1 1.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 2 2 | 6 1.8|
Fibrosis, Focal | | 1 1.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 | 4 1.8|
Foreign Body | | 1 2.0|
Fungus | X | 1 |
Hemorrhage | 2 2 | 3 2.3|
Mucosa, Inflammation, Acute | 2 | 6 1.5|
Mucosa, Inflammation, Chronic Active | 2 3 | 2 2.5|
Nasolacrimal Duct, Cyst | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7| | |
DAY ON TEST | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3| | |
| 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Sinus, Inflammation, Acute | | 1 2.0|
Vein, Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Bilateral, Lens, Cataract | | 1 3.0|
Lens, Cataract | 2 4 | 2 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 2 2 2 3 | 7 2.1|
Congestion | | 3 2.0|
Hemorrhage | | 1 2.0|
Mineralization, Focal | 1 | 2 1.0|
Mineralization, Multifocal | | 2 1.0|
Nephropathy | 3 1 3 2 1 1 2 3 1 3 2 2 | 38 1.9|
Cortex, Renal Tubule, Necrosis, Focal| | 1 2.0|
Renal Tubule, Epithelium, | | |
Pigmentation | 2 | 4 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 52 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|
| 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + I + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + I M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
Submucosa, Inflammation, Acute, Focal| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X X X X|
Congestion | |
Cytoplasmic Alteration, Focal | 1 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Focal | |
Inflammation, Granulomatous, | |
Multifocal | 2 2 1 2 1|
Necrosis, Acute, Focal | |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic, Multifocal | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic | |
Duct, Inflammation, Chronic | 1 |
Duct, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|
| 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 1|
Muscularis, Hypertrophy, Focal | |
Submucosa, Inflammation, Acute | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Acute | 2 |
Necrosis, Acute | 2 |
Arteriole, Submucosa, Thrombosis | 3 |
Serosa, Inflammation, Chronic, | |
Multifocal | 2 |
Submucosa, Inflammation, Chronic | 2|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 2 1 1 1|
Coronary Artery, Inflammation, | |
Chronic | |
Pericardium, Fibrosis, Focal | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Congestion | |
Hemorrhage | |
Hyperplasia, Focal | 1 1 2 1 |
Hypertrophy, Focal | 1 1 |
Vacuolization Cytoplasmic, Focal | 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + I + +|
Congestion, Focal | 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Autolysis | |
Congestion, Focal | |
Hemorrhage | |
Pars Distalis, Angiectasis | 3 3 2|
Pars Distalis, Cyst | 2 2|
Pars Distalis, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|
| 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Distalis, Vacuolization Nuclear | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 3|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Atrophy | |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 3 |
Endometrium, Fibrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Lymphocyte, Depletion Cellular | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Pigmentation | |
Capsule, Fibrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + I I + + M + + + + + +|
Cyst | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Medulla, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|
| 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 1 1 1 1 1 2 2|
Inflammation, Acute | |
Inflammation, Chronic Active, | |
Multifocal | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Face, Inflammation, Chronic Active, | |
Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Congestion | |
Cerebellum, Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 2 2 3 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous, | |
Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + +|
Foreign Body | |
Fungus | X |
Mucosa, Inflammation, Acute | 3 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Cyst | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|
| 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | 1 |
Sinus, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | 3 |
Sclera, Mineralization, Focal | 1 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Hemorrhage | |
Inflammation, Multifocal, Suppurative| |
Mineralization, Multifocal | 1 1 1 1 |
Nephropathy | 1 1 2 1 1 3 2 1 2 1 1 1|
Cortex, Renal Tubule, Necrosis | |
Renal Tubule, Epithelium, | |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M +|
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|
| 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + +|
Parasite Metazoan | X X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | X X|
Submucosa, Inflammation, Acute, Focal| 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X |
Basophilic Focus, Multiple | X X X X X |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Acute, Focal | |
Inflammation, Granulomatous, | |
Multifocal | 3 2 2 2 1 |
Necrosis, Acute, Focal | 1 |
Bile Duct, Hyperplasia | 1 1|
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic, Multifocal | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 2 1 1 2|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic | 1 |
Duct, Inflammation, Chronic | |
Duct, Inflammation, Chronic Active | 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|
| 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 1|
Muscularis, Hypertrophy, Focal | 2|
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Acute | |
Necrosis, Acute | |
Arteriole, Submucosa, Thrombosis | |
Serosa, Inflammation, Chronic, | |
Multifocal | |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1|
Coronary Artery, Inflammation, | |
Chronic | |
Pericardium, Fibrosis, Focal | 2 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Congestion | |
Hemorrhage | 3 |
Hyperplasia, Focal | 2 1 1 |
Hypertrophy, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + M + + + + + + + M + M|
Congestion, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion, Focal | 2 |
Hemorrhage | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 1 3 2 |
Pars Distalis, Ectasia | 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|
| 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 1 2 2 |
Pars Distalis, Vacuolization Nuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 3 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 1 2|
Inflammation, Chronic | 1 1 1 1 2 1 |
Inflammation, Chronic Active | 2 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
Endometrium, Fibrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Lymphocyte, Depletion Cellular | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Pigmentation | 2 2 2 |
Capsule, Fibrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + + + +|
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Medulla, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|
| 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + I + + +|
Galactocele | 2 2 |
Hyperplasia | 1 3 2 1 2 2 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active, | |
Multifocal | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Face, Inflammation, Chronic Active, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Cerebellum, Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 2 3 2 2|
Hemorrhage | |
Inflammation, Chronic | 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | |
Mucosa, Inflammation, Acute | 2 1 2 3 |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | 3 2 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|
| 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | 1 1 |
Sinus, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
Sclera, Mineralization, Focal | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | 1 |
Hemorrhage | 3 |
Inflammation, Multifocal, Suppurative| |
Mineralization, Multifocal | 1 1 1 1 1 1 1 2 |
Nephropathy | 2 2 2 3 2 1 1 2 2 2 1 2|
Cortex, Renal Tubule, Necrosis | |
Renal Tubule, Epithelium, | |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + M + + + + + + + +|
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 52 |
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + | 51 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Parasite Metazoan | X | 3 |
Submucosa, Inflammation, Acute, Focal| | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 53 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X X | 16 |
Basophilic Focus, Multiple | X X X X | 14 |
Congestion | 1 | 1 1.0|
Cytoplasmic Alteration, Focal | | 4 1.8|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Acute, Focal | 2 1 | 2 1.5|
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 1 1 1 1 1 | 18 1.4|
Necrosis, Acute, Focal | | 1 1.0|
Bile Duct, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Fat, Necrosis, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + M + + I + + + + + + + + + + | 51 |
Atrophy, Focal | 2 1 | 10 1.3|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 53 |
Atrophy, Focal | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 2.0|
Inflammation, Chronic | | 1 1.0|
Duct, Inflammation, Chronic | 1 | 2 1.0|
Duct, Inflammation, Chronic Active | 1 | 7 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
Epithelium, Hyperplasia | 2 2 | 4 1.5|
Muscularis, Hypertrophy, Focal | | 1 2.0|
Submucosa, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 53 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Necrosis, Acute | 2 2 | 3 2.0|
Arteriole, Submucosa, Thrombosis | | 1 3.0|
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Submucosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.1|
Coronary Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
Pericardium, Fibrosis, Focal | | 1 2.0|
Valve, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + | 52 |
Angiectasis, Focal | | 1 2.0|
Congestion | 2 1 | 2 1.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal | 1 2 2 2 1 | 12 1.4|
Hypertrophy, Focal | 2 | 4 1.3|
Vacuolization Cytoplasmic, Focal | 3 1 | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Focal | 1 2 2 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + I + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M + + M + + + + + | 42 |
Congestion, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 | 1 2.0|
Congestion, Focal | | 1 2.0|
Hemorrhage | 2 2 | 2 2.0|
Pars Distalis, Angiectasis | 1 | 5 2.4|
Pars Distalis, Cyst | 2 2 | 7 2.0|
Pars Distalis, Ectasia | | 1 4.0|
Pars Distalis, Hyperplasia | 2 1 2 2 2 1 | 13 1.7|
Pars Distalis, Vacuolization Nuclear | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M + + + + + + + + | 52 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 2 1 1 | 16 1.3|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + + + M + + + M + + M + | 48 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | 3 2 | 4 2.0|
Inflammation, Chronic | 2 1 1 1 | 12 1.2|
Inflammation, Chronic Active | 2 | 5 2.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 53 |
Atrophy | 3 | 1 3.0|
Follicle, Cyst | 3 1 2 | 5 2.0|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 53 |
Dilatation | 3 | 3 3.0|
Hemorrhage | | 1 3.0|
Endometrium, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Congestion | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 53 |
Congestion | 1 | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Lymphocyte, Depletion Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 53 |
Fibrosis | | 1 2.0|
Pigmentation | 3 | 4 2.3|
Capsule, Fibrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | I + + + + + + I + + M I + + + + M | 44 |
Cyst | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Medulla, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 51 |
Galactocele | X 2 | 5 2.3|
Hyperplasia | 2 1 2 1 1 1 3 2 | 23 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 1 | 1 1.0|
Duct, Ectasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + + + + + + + + | 52 |
Face, Inflammation, Chronic Active, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 53 |
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 | 2 1.5|
Cerebellum, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 3 2 | 13 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 2 1.0|
Perivascular, Inflammation, Chronic | 1 1 2 1 1 1 | 12 1.1|
__________________________________________________________________________|____________|
Nose | A + + A A + + + + + + + + + + + + | 48 |
Foreign Body | | 1 1.0|
Fungus | | 1 |
Mucosa, Inflammation, Acute | | 5 2.2|
Mucosa, Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Cyst | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 3 2 3 | 6 2.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 | 4 1.8|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 3 1.0|
Sinus, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 2 | 2 2.5|
Retina, Degeneration | 2 | 2 2.5|
Sclera, Mineralization, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + | 52 |
Autolysis | | 1 2.0|
Congestion | | 1 1.0|
Hemorrhage | | 1 3.0|
Inflammation, Multifocal, Suppurative| 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3| | |
| 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization, Multifocal | 1 1 1 | 15 1.1|
Nephropathy | 1 2 1 3 1 2 1 2 2 2 1 | 35 1.6|
Cortex, Renal Tubule, Necrosis | 4 | 1 4.0|
Renal Tubule, Epithelium, | | |
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + I + + + + + + + + + + | 49 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|
DAY ON TEST | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|
| 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | |
Basophilic Focus | X 2 X |
Basophilic Focus, Multiple | X |
Congestion | |
Cytoplasmic Alteration, Focal | 2 3 2 2 3 |
Cytoplasmic Alteration, Multifocal | 2 |
Fatty Change, Diffuse | 2 |
Fatty Change, Multifocal | |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Necrosis, Acute, Focal | |
Pigmentation, Diffuse | |
Thrombosis | 2 |
Vacuolization Cytoplasmic, Focal | |
Artery, Thrombosis | |
Bile Duct, Hyperplasia | 1 3 2 1 3 3 2 2 1 |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 2 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Chronic, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 2 2|
Cytoplasmic Alteration, Focal | 1 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|
DAY ON TEST | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|
| 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 1 |
Duct, Ectasia, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 |
Necrosis, Focal | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Mineralization | 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 |
Inflammation, Chronic | 2 1 2 2 3 1 2 2 1 2 1 2 2 1 2 2 3|
Mineralization | |
Artery, Mineralization, Multifocal | 2 |
Atrium Left, Thrombosis | 4 |
Valve, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 |
Hypertrophy, Focal | 1 |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 1 1|
Pars Nervosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|
DAY ON TEST | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|
| 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M +|
Inflammation, Acute | 1 1 2 |
Inflammation, Chronic | 1 2 1 1 2 2 2 |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + M I|
Hyperplasia, Focal | 1 |
Inflammation, Acute | 2 1 2 3 |
Inflammation, Chronic | |
Epithelium, Degeneration, Focal | |
__________________________________________________________________________|
Seminal Vesicle | M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
Mineralization, Focal | 1|
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 2 2 1 1 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 3|
Hyperplasia | 2 |
Hypoplasia | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation, Focal, | |
Granulomatous | |
Inguinal, Inflammation, Acute, | |
Multifocal | 2 |
Mediastinal, Congestion | 2 2 |
Mediastinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|
DAY ON TEST | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|
| 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hemorrhage, Multifocal | |
Pigmentation, Diffuse | 2 |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | I I + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Acute | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | 3|
Inflammation, Focal, Granulomatous | 2 2 |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|
DAY ON TEST | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|
| 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Fungus | X |
Mucosa, Concretion, Focal | |
Mucosa, Inflammation, Acute | 3 2 |
Mucosa, Inflammation, Chronic Active | 3 2 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
Retina, Degeneration | |
Sclera, Mineralization, Focal | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Mineralization, Multifocal | 2 |
Nephropathy | 3 3 2 1 4 2 2 2 4 4 2 2 3 3 2 3 1 4 3|
Cortex, Cyst | 1 |
Medulla, Inflammation, Multifocal | 3 |
Pelvis, Calculus Gross Observation | |
Pelvis, Inflammation, Acute | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Epithelium, | |
Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|
| 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | |
Congestion | 2 |
Cytoplasmic Alteration, Focal | 2 2 2 2 |
Cytoplasmic Alteration, Multifocal | 2 |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | |
Inflammation, Granulomatous, | |
Multifocal | |
Necrosis, Acute, Focal | 2 |
Pigmentation, Diffuse | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | 1 |
Artery, Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 1 2 2 1 |
Hepatocyte, Degeneration, Cystic, | |
Focal | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Chronic, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 2 1 1 |
Cytoplasmic Alteration, Focal | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|
| 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Duct, Ectasia, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Necrosis, Focal | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + M + + + + +|
Fibrosis, Focal | |
Inflammation, Chronic | 1 3 1 1 3 2 3 2 2 1 1 1 1 1 2 2|
Mineralization | 1 |
Artery, Mineralization, Multifocal | |
Atrium Left, Thrombosis | 1 4 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 2 2 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
Pars Nervosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|
| 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + +|
Inflammation, Acute | 1 2 1 1 2|
Inflammation, Chronic | 1 2 1 2 2 |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 |
Epithelium, Degeneration, Focal | 1 |
__________________________________________________________________________|
Seminal Vesicle | M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 |
Mineralization, Focal | |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Hyperplasia | |
Hypoplasia | 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Iliac, Inflammation, Focal, | |
Granulomatous | 3 |
Inguinal, Inflammation, Acute, | |
Multifocal | |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|
| 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Hemorrhage, Multifocal | |
Pigmentation, Diffuse | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | I I + + + + + + + + + + + + + I + +|
Cyst, Multiple | 3 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 2 |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
Subcutaneous Tissue, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic | 1 |
Inflammation, Focal, Granulomatous | 1 |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|
| 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + +|
Cyst | 4 X |
Fungus | X X X X|
Mucosa, Concretion, Focal | |
Mucosa, Inflammation, Acute | 3 1 2 |
Mucosa, Inflammation, Chronic Active | 3 2 3 3|
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Retina, Degeneration | 3 |
Sclera, Mineralization, Focal | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Mineralization, Multifocal | |
Nephropathy | 3 4 1 2 3 2 1 3 3 2 3 3 2 2 3 3 3 3|
Cortex, Cyst | |
Medulla, Inflammation, Multifocal | |
Pelvis, Calculus Gross Observation | X |
Pelvis, Inflammation, Acute | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + | 52 |
Inflammation, Acute | 1 1 | 2 1.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + | 53 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Parasite Metazoan | X X X | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | 2 | 1 2.0|
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 52 |
Autolysis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + | 51 |
Autolysis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 53 |
Angiectasis, Focal | 2 | 1 2.0|
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X | 9 2.0|
Basophilic Focus, Multiple | X X | 3 |
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | | 9 2.2|
Cytoplasmic Alteration, Multifocal | | 2 2.0|
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Multifocal | 3 | 1 3.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Necrosis, Acute, Focal | 1 | 2 1.5|
Pigmentation, Diffuse | 2 | 1 2.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Artery, Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 3 2 2 3 3 | 20 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis, Chronic, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + M + + + + + | 52 |
Atrophy, Focal | 2 2 2 2 1 | 16 1.4|
Cytoplasmic Alteration, Focal | | 1 1.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 52 |
Atrophy, Diffuse | | 1 1.0|
Duct, Ectasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | 2 3 | 3 2.3|
Inflammation, Chronic | 2 | 2 2.5|
Necrosis, Focal | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 52 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 2.0|
Necrosis, Focal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 52 |
Fibrosis, Focal | | 2 3.0|
Inflammation, Chronic | 2 1 2 2 3 2 2 2 3 2 2 2 2 2 2 | 48 1.9|
Mineralization | 2 | 2 1.5|
Artery, Mineralization, Multifocal | | 1 2.0|
Atrium Left, Thrombosis | 3 X | 5 3.0|
Valve, Thrombosis | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 52 |
Hyperplasia, Focal | 1 2 1 1 | 9 1.3|
Hypertrophy, Focal | 2 | 5 1.6|
Necrosis, Focal | | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | 2 2 | 2 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 3 | 7 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + | 51 |
Hyperplasia, Focal | 1 2 | 10 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + | 52 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + M + + M + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 53 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Cyst | X | 2 2.0|
Pars Distalis, Hyperplasia | 2 2 | 8 1.8|
Pars Nervosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 53 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 1 1 1 1 | 11 1.4|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + M + + + | 52 |
Duct, Epithelium, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 51 |
Inflammation, Acute | 1 1 | 10 1.3|
Inflammation, Chronic | 1 2 2 2 1 1 | 18 1.6|
Duct, Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + I + M + + + + + + + + + + + + | 48 |
Hyperplasia, Focal | | 4 1.0|
Inflammation, Acute | 4 | 6 2.7|
Inflammation, Chronic | | 1 1.0|
Epithelium, Degeneration, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | M M M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 53 |
Atrophy | 3 | 6 2.7|
Mineralization, Focal | | 1 1.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 | 6 1.5|
Seminiferous Tubule, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Megakaryocyte | | 1 3.0|
Hyperplasia | 2 | 2 2.0|
Hypoplasia | 2 | 2 2.0|
Myeloid Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 53 |
Axillary, Congestion | 2 | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Iliac, Inflammation, Focal, | | |
Granulomatous | | 1 3.0|
Inguinal, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
Mediastinal, Congestion | 2 2 2 | 5 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 53 |
Fibrosis, Focal | 2 | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 2 | 2 2.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
Pigmentation, Diffuse | | 1 2.0|
Capsule, Fibrosis, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + I + | 47 |
Cyst, Multiple | | 1 3.0|
Hemorrhage | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Cystic | 2 | 1 2.0|
Hyperplasia | 1 | 2 1.5|
Duct, Ectasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acute | 3 | 1 3.0|
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 53 |
Fibrous Osteodystrophy | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 53 |
Congestion | | 1 1.0|
Hemorrhage, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 53 |
Congestion | | 2 2.0|
Inflammation, Acute, Focal | 2 | 2 2.0|
Inflammation, Chronic | 1 | 3 1.7|
Inflammation, Focal, Granulomatous | 2 | 4 1.8|
Mineralization, Focal | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.0|
Perivascular, Inflammation, Chronic | 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 52 |
Cyst | | 3 2.5|
Fungus | X X X | 8 |
Mucosa, Concretion, Focal | 2 | 1 2.0|
Mucosa, Inflammation, Acute | 3 2 | 7 2.3|
Mucosa, Inflammation, Chronic Active | 3 3 | 9 2.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3| | |
| 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | | 2 2.5|
Retina, Degeneration | | 1 3.0|
Sclera, Mineralization, Focal | 2 | 3 2.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 53 |
Calculus Micro Observation Only | | 1 |
Mineralization, Multifocal | | 1 2.0|
Nephropathy | 3 3 3 3 3 2 3 2 3 3 3 2 3 4 4 3 | 53 2.7|
Cortex, Cyst | | 1 1.0|
Medulla, Inflammation, Multifocal | | 1 3.0|
Pelvis, Calculus Gross Observation | | 1 |
Pelvis, Inflammation, Acute | 1 | 2 1.5|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 | 2 2.5|
Renal Tubule, Epithelium, | | |
Pigmentation | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + M + + + + + + + | 51 |
Inflammation, Acute | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|
| 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X X X X|
Clear Cell Focus | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 |
Necrosis, Acute, Focal | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 2 1 1 3 2 1|
Centrilobular, Fatty Change | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 1 2 2 1 1|
Congestion, Focal | |
Hyperplasia, Focal | 3 |
Inflammation, Chronic | |
Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|
| 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Ectasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic | 2 |
Duct, Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 |
Inflammation, Chronic Active | 3 |
Mineralization | 3 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Mineralization | 4 |
Necrosis, Focal | 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2 2 2 2 1 2 3 1 2 2 2 1 1 2 1|
Mineralization | 3 |
Atrium Left, Thrombosis | X 3 3 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 1 1 2 1|
Hyperplasia | 3 |
Hypertrophy, Focal | 1 1 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Thrombosis | |
Bilateral, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|
| 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 1 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 1 1 |
Pars Intermedia, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation, Acute | 3 2 2 2 2 |
Inflammation, Chronic | 1 1 2 1 1 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|
| 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Inflammation, Chronic | 4 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia | |
Necrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + I + + + + +|
Ectasia | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 1 |
Mineralization | |
Pigmentation | |
Duct, Ectasia | 1 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Meninges, Vein, Cerebrum, Thrombosis | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Fibrosis, Multifocal | 1 1 |
Hemorrhage, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|
| 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 |
Alveolus, Pigmentation | 1 |
Artery, Media, Hypertrophy | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Foreign Body | 2 |
Fungus | X |
Mucosa, Inflammation, Acute | 2 1 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Respiratory Epithelium, Hyperplasia, | |
Papillary | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 1 |
Lens, Cataract | |
Sclera, Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | |
Nephropathy | 1 1 3 2 2 4 4 1 3 3 3 3 2 3 3 3 3 2 3 3|
Cortex, Cyst | |
Pelvis, Inflammation, Acute | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Epithelium, | |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|
| 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X |
Clear Cell Focus | X |
Congestion | 2 1 |
Cytoplasmic Alteration, Focal | 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Inflammation, Chronic | |
Inflammation, Granulomatous, | |
Multifocal | |
Necrosis, Acute, Focal | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | 1 |
Bile Duct, Hyperplasia | 2 1 |
Centrilobular, Fatty Change | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Hepatocyte, Degeneration, Cystic, | |
Focal | 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Congestion, Focal | |
Hyperplasia, Focal | |
Inflammation, Chronic | |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|
| 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Ectasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 1 |
Inflammation, Chronic | |
Duct, Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Mineralization | |
Epithelium, Hyperplasia | 3 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | 2 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 3 2 2 3 2 3 2 2 2 1 2 |
Mineralization | 2 |
Atrium Left, Thrombosis | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia, Focal | 1 |
Hyperplasia | |
Hypertrophy, Focal | 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + M + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 2 1 |
Thrombosis | |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|
| 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 |
Pars Intermedia, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 1 2 1 2 2 1 1 1 2|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + +|
Axillary, Hyperplasia | 3 |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|
| 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Inflammation, Chronic | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia | |
Necrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + I + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + +|
Fibrosis | 1|
Hyperplasia | 1 2 1 |
Mineralization | 1 |
Pigmentation | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + +|
Hemorrhage | 3 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Meninges, Vein, Cerebrum, Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Congestion | 1 1 |
Fibrosis, Multifocal | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|
| 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
15 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 1 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Alveolus, Pigmentation | |
Artery, Media, Hypertrophy | 2 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Autolysis | |
Foreign Body | 2|
Fungus | X X |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 3 4 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 |
Respiratory Epithelium, Hyperplasia, | |
Papillary | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Bilateral, Lens, Cataract | |
Lens, Cataract | 3|
Sclera, Mineralization, Focal | 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | |
Nephropathy | 2 4 3 2 3 4 3 3 3 3 3 4 3 4 3 4|
Cortex, Cyst | 2 2 |
Pelvis, Inflammation, Acute | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + | 52 |
Autolysis | 3 | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 52 |
Autolysis | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 52 |
Autolysis | 4 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 53 |
Angiectasis, Focal | 2 | 1 2.0|
Basophilic Focus | | 1 |
Basophilic Focus, Multiple | | 10 |
Clear Cell Focus | | 1 |
Congestion | | 2 1.5|
Cytoplasmic Alteration, Focal | | 3 1.7|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Focal | 1 | 1 1.0|
Inflammation, Chronic | 1 2 | 3 1.3|
Inflammation, Granulomatous, | | |
Multifocal | 1 | 3 1.0|
Necrosis, Acute, Focal | 2 | 1 2.0|
Thrombosis | X | 1 |
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 3 2 | 11 1.8|
Centrilobular, Fatty Change | 3 | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 3.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Focal | 1 1 1 1 3 1 2 1 | 20 1.3|
Congestion, Focal | 2 | 1 2.0|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Artery, Mineralization | | 1 2.0|
Duct, Ectasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute, Focal | | 3 1.0|
Inflammation, Chronic | | 1 2.0|
Duct, Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 52 |
Inflammation, Acute | 2 2 | 4 1.8|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 3.0|
Epithelium, Hyperplasia | 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 52 |
Infiltration Cellular, Lymphocyte | 2 | 4 1.8|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 1.5|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 2 | 4 2.5|
Necrosis, Focal | 1 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | 3 | 1 3.0|
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 3 2 2 1 1 2 2 2 1 1 1 1 | 45 1.8|
Mineralization | 2 | 3 2.3|
Atrium Left, Thrombosis | 1 | 4 2.3|
Valve, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + | 51 |
Cyst | | 1 1.0|
Hyperplasia, Focal | 1 2 2 | 8 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Hypertrophy, Focal | 1 | 5 1.0|
Necrosis, Focal | 1 1 | 2 1.0|
Vacuolization Cytoplasmic, Focal | 2 2 | 10 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + | 50 |
Hyperplasia, Focal | 1 | 6 1.2|
Thrombosis | 4 | 1 4.0|
Bilateral, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + | 47 |
Hyperplasia, Focal | | 1 1.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 52 |
Hemorrhage | 1 | 1 1.0|
Pars Distalis, Angiectasis | 2 1 | 3 1.7|
Pars Distalis, Cyst | 2 | 2 1.5|
Pars Distalis, Hyperplasia | 1 2 | 7 1.3|
Pars Intermedia, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 53 |
C-Cell, Hyperplasia | 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + M + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + | 52 |
Cyst | 1 | 1 1.0|
Hyperplasia | | 2 2.0|
Inflammation, Acute | | 7 2.1|
Inflammation, Chronic | 1 2 1 1 1 1 2 1 1 1 1 1 2 | 28 1.3|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + + + + + + + + | 52 |
Hyperplasia, Focal | 1 | 4 1.5|
Inflammation, Chronic | 2 1 1 | 5 1.2|
Inflammation, Chronic Active | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Testes | M + + M + + + + + + + + + + + + + | 51 |
Atrophy | 2 4 | 6 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 2 | 6 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + M + + + + + + + + + + + + | 52 |
Hyperplasia | 2 | 2 2.0|
Myelofibrosis | 2 | 2 1.5|
Myeloid Cell, Hyperplasia | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 52 |
Axillary, Hyperplasia | | 1 3.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Inflammation, Chronic | | 1 4.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 52 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 2 1.5|
Hyperplasia | 2 | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 53 |
Fibrosis | 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 1 3.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + I + + + + I + + + + + + | 48 |
Ectasia | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 52 |
Fibrosis | | 1 1.0|
Hyperplasia | 1 1 | 6 1.2|
Mineralization | | 1 1.0|
Pigmentation | 1 | 1 1.0|
Duct, Ectasia | 1 1 1 | 8 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + + + + + + + + | 51 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + + + + + + + + + + + + | 52 |
Fibrous Osteodystrophy | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 53 |
Hemorrhage, Focal | 2 | 1 2.0|
Meninges, Vein, Cerebrum, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 2 1 | 6 1.3|
Fibrosis, Multifocal | | 2 1.0|
Hemorrhage, Focal | 2 | 2 1.5|
Inflammation, Chronic | | 4 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 4 1.8|
Alveolus, Pigmentation | | 1 1.0|
Artery, Media, Hypertrophy | | 1 2.0|
Perivascular, Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 3 | 2 2.5|
Foreign Body | 2 | 3 2.0|
Fungus | X X X X X | 8 |
Mucosa, Inflammation, Acute | 2 | 4 1.8|
Mucosa, Inflammation, Chronic | 2 3 1 | 3 2.0|
Mucosa, Inflammation, Chronic Active | 3 3 4 2 | 8 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
Respiratory Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6| | |
DAY ON TEST | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6| | |
| 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
15 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Papillary | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Bilateral, Lens, Cataract | | 1 1.0|
Lens, Cataract | | 1 3.0|
Sclera, Mineralization, Focal | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 3 3 3 | 6 2.8|
Congestion | 2 | 1 2.0|
Nephropathy | 4 2 3 2 3 3 2 2 2 2 2 2 2 3 3 | 51 2.7|
Cortex, Cyst | | 2 2.0|
Pelvis, Inflammation, Acute | 2 | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 | 3 2.3|
Renal Tubule, Epithelium, | | |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + | 52 |
Hemorrhage | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|
DAY ON TEST | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|
| 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
Wall, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis, Acute, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | |
Basophilic Focus, Multiple | X |
Clear Cell Focus | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
Inflammation, Acute, Multifocal | 1 |
Necrosis, Acute, Focal | |
Vacuolization Cytoplasmic, Focal | 3 |
Bile Duct, Hyperplasia | 1 1 1 |
Centrilobular, Fatty Change | |
Hepatocyte, Degeneration, Cystic, | |
Focal | |
Hepatocyte, Hypertrophy, Focal | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 3 1 1|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Duct, Ectasia, Focal | |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Duct, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|
DAY ON TEST | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|
| 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Periductular, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Mineralization | |
Epithelium, Hyperplasia | 2 1 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic | |
Mineralization | |
Necrosis, Focal | 1 3 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 3 2 2 2 2 1 2 1 1|
Mineralization | |
Atrium Left, Thrombosis | 3 |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1|
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 |
Mineralization, Focal | |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + M + M I M|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|
DAY ON TEST | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|
| 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Acute | 3 2 1 2 |
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Mineralization | 2 |
__________________________________________________________________________|
Seminal Vesicle | + M M + M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Infarct, Diffuse | |
Interstitial Cell, Hyperplasia | 1 2 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + +|
Hypoplasia | 2 |
Myelofibrosis | 2 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 |
Pancreatic, Fibrosis, Focal | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|
DAY ON TEST | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|
| 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Congestion | |
Cyst, Multiple | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
Hyperplasia | 1 2 1|
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Face, Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hydrocephalus | |
Cerebellum, Pigmentation, Focal | |
Thalamus, Inflammation, Chronic, | |
Focal | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Inflammation, Chronic | 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Inflammation, Chronic | |
Active, Multifocal | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Perivascular, Inflammation, Chronic | |
Pleura, Fibrosis, Focal | 1 |
Pleura, Infiltration Cellular, Focal,| |
Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|
DAY ON TEST | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|
| 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Subpleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 2 |
Fungus | X |
Metaplasia, Squamous | |
Mucosa, Inflammation, Acute | 2|
Mucosa, Inflammation, Chronic Active | 4 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Vomeronasal Organ, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
Sclera, Mineralization, Focal | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 1 2 1 2 2 4 2 3 3 3 2 1 4 1 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia,| |
Focal, Papillary | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|
| 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + I + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + +|
Autolysis | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X |
Congestion | |
Cytoplasmic Alteration, Focal | 3 |
Inflammation, Acute, Multifocal | |
Necrosis, Acute, Focal | 1 1 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 3 2 1 1 3 1 |
Centrilobular, Fatty Change | |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2|
Hepatocyte, Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Duct, Ectasia, Focal | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Duct, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|
| 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Periductular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | 2 2 |
Epithelium, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Inflammation, Chronic | 2 |
Mineralization | 2 2 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + M + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 1 2 2 2 2 3 1 2 1 3 1 2 2|
Mineralization | 3 3 |
Atrium Left, Thrombosis | X 3 |
Perivascular, Inflammation, Chronic | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 1 2 |
Hypertrophy, Focal | 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 |
Mineralization, Focal | 3 |
Thrombosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + M + M M +|
Hyperplasia | 4 1 2 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|
| 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + +|
Ectasia | 3 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 1 1 1 1 1 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 |
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Testes | + + + + + + M + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 4 |
Infarct, Diffuse | |
Interstitial Cell, Hyperplasia | 2 1 2 |
Seminiferous Tubule, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 4 |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Pancreatic, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|
| 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + I + + +|
Congestion | 2 |
Cyst, Multiple | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 |
Hyperplasia | 1 2 1 2 1 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Face, Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 X 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hydrocephalus | 1 |
Cerebellum, Pigmentation, Focal | 2 |
Thalamus, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 1 2 |
Inflammation, Chronic | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Bronchiole, Inflammation, Chronic | |
Active, Multifocal | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Perivascular, Inflammation, Chronic | 1 1 |
Pleura, Fibrosis, Focal | |
Pleura, Infiltration Cellular, Focal,| |
Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
_____________________________________________________________________________________________________________________
| 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|
DAY ON TEST | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|
| 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Subpleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 2 |
Fungus | X X |
Metaplasia, Squamous | 2 2 2 2 2 |
Mucosa, Inflammation, Acute | 1 1 4 2 1 |
Mucosa, Inflammation, Chronic Active | 3 2 2 2 1 2 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1|
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 3 |
Lens, Cataract | |
Retina, Degeneration | |
Sclera, Mineralization, Focal | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 2 4 4 2 4 2 4 2 4 2 3 3 1 1 3 4 3 4|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 |
Renal Tubule, Epithelium, | |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal, Papillary | 3 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 53 |
Wall, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 53 |
Parasite Metazoan | X X X X | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 52 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 53 |
Perivascular, Inflammation, Chronic | 3 | 1 3.0|
Serosa, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 3 | 1 3.0|
Necrosis, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 51 |
Autolysis | 1 | 1 1.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 53 |
Basophilic Focus | X X X 1 | 5 1.0|
Basophilic Focus, Multiple | | 3 |
Clear Cell Focus | | 1 |
Congestion | 1 | 1 1.0|
Cytoplasmic Alteration, Focal | 2 2 | 4 2.3|
Inflammation, Acute, Multifocal | | 1 1.0|
Necrosis, Acute, Focal | 2 | 3 1.3|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.5|
Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 | 17 1.5|
Centrilobular, Fatty Change | 2 | 1 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 2 | 2 2.0|
Hepatocyte, Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + I + + + + + + + + | 52 |
Atrophy, Focal | 1 1 2 2 1 2 | 14 1.4|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Ectasia, Focal | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 3 1 | 2 2.0|
Duct, Inflammation, Chronic Active | | 1 1.0|
Periductular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 53 |
Perivascular, Inflammation, Chronic | 2 | 1 2.0|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | 3 | 3 2.7|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 2 2.0|
Epithelium, Hyperplasia | | 2 1.5|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 53 |
Hemorrhage, Focal | 1 | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 4 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 3 2.3|
Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Epithelium, Hyperplasia, Focal | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + | 52 |
Aorta, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 2 3 3 1 2 2 2 2 2 2 2 1 1 1 1 2 | 46 1.7|
Mineralization | | 2 3.0|
Atrium Left, Thrombosis | | 3 3.0|
Perivascular, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 53 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 1 1 2 2 2 2 2 2 | 12 1.8|
Hypertrophy, Focal | | 3 1.7|
Vacuolization Cytoplasmic, Focal | 1 2 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Focal | 2 | 7 1.7|
Mineralization, Focal | | 1 3.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + I + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + + + + M + + + M M + + | 37 |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 53 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 2 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 53 |
C-Cell, Hyperplasia | 1 2 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + | 52 |
Ectasia | | 1 3.0|
Inflammation, Acute | 3 3 | 8 2.3|
Inflammation, Chronic | 1 2 2 1 1 1 | 16 1.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Acute | 1 3 | 4 2.0|
Inflammation, Chronic | 1 | 2 2.0|
Mineralization | 1 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | M M M M M M M M M M + M M M M M M M | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + | 52 |
Atrophy | 3 | 1 3.0|
Hemorrhage | | 1 4.0|
Infarct, Diffuse | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 1 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 52 |
Hypoplasia | | 2 3.0|
Myelofibrosis | | 2 2.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 53 |
Mediastinal, Congestion | | 2 2.5|
Pancreatic, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 53 |
Congestion | | 1 1.0|
Hyperplasia, Re Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 3 | 2 2.5|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + I + + + + + + + + I + + + | 50 |
Congestion | 2 | 2 2.0|
Cyst, Multiple | 1 | 3 1.7|
Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 53 |
Hyperplasia, Cystic | | 2 1.5|
Hyperplasia | | 9 1.4|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic, Focal | | 1 3.0|
Face, Inflammation, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 52 |
Fibrous Osteodystrophy | | 3 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage, Focal | | 1 1.0|
Hydrocephalus | | 1 1.0|
Cerebellum, Pigmentation, Focal | | 1 2.0|
Thalamus, Inflammation, Chronic, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 53 |
Congestion | 2 2 2 | 10 2.0|
Inflammation, Chronic | | 4 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Bronchiole, Inflammation, Chronic | | |
Active, Multifocal | 2 | 1 2.0|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | | 2 1.0|
Pleura, Fibrosis, Focal | | 1 1.0|
Pleura, Infiltration Cellular, Focal,| | |
Histiocyte | | 1 2.0|
Subpleura, Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 | 3 2.7|
Congestion | | 2 2.0|
Fungus | X X | 5 |
Metaplasia, Squamous | 2 | 6 2.0|
Mucosa, Inflammation, Acute | 3 3 2 | 9 2.1|
Mucosa, Inflammation, Chronic Active | 3 3 3 2 3 3 3 | 15 2.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 2 1.5|
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Chronic | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05705-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 04/29/97
Route: GAVAGE Time: 11:37:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7| | |
DAY ON TEST | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2| | |
| 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Bilateral, Lens, Cataract | | 1 3.0|
Lens, Cataract | 4 | 2 4.0|
Retina, Degeneration | 4 | 2 4.0|
Sclera, Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 53 |
Congestion | 1 | 1 1.0|
Nephropathy | 2 4 4 4 1 2 3 3 3 4 4 1 2 2 3 | 48 2.6|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 2 2.0|
Renal Tubule, Epithelium, | | |
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 53 |
Inflammation, Acute | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Focal, Papillary | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------