TR 396 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05705 MONOCHLOROACETIC ACID TIME: 21:26:01
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60231
CONT: 05700-05 CAS: 79-11-8
PATHOLOGIST: P. HILDEBRANDT
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05705 MONOCHLOROACETIC ACID TIME: 21:26:01
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60231
CONT: 05700-05 CAS: 79-11-8
PATHOLOGIST: P. HILDEBRANDT
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 25 CENSORED DEATHS 18 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 291 350 436 447 506 512 575 584 584 585 |
| 621 629 631 656 674 679 691 691 693 705 |
| 714 715 718 725 728 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 456 456 456 456 456 456 456 538 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 32 CENSORED DEATHS 17 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 284 364 411 427 448 556 557 557 569 588 |
| 599 602 611 625 633 633 644 647 647 647 |
| 668 686 687 696 706 706 718 718 718 725 |
| 728 728 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 35 CENSORED DEATHS 19 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 336 339 344 351 366 450 457 477 486 492 |
| 513 519 522 528 532 535 556 564 564 577 |
| 624 632 632 638 642 653 657 666 669 672 |
| 682 690 698 718 718 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 359 417 456 456 456 456 456 456 456 |
| |
==================================================================================
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 96.7 96.7 93.3 89.5 81.7 74.0 52.5 |
| | |
| | |
|15 MG/KG | 100.0 100.0 100.0 96.7 95.0 91.7 91.7 78.3 63.0 40.1 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 93.3 91.6 85.9 69.9 61.9 48.0 32.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.5% 40.1% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.011 P=0.287 P=0.015 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.6 610.4 557.1 |
|NATURAL DEATHS (C) | (24.2) (20.1) (19.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 576.9 569.5 528.0 |
|(STANDARD ERROR) | (23.4) (23.1) (22.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 16 CENSORED DEATHS 17 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 215 344 520 529 558 565 595 626 637 653 |
| 672 675 690 691 693 693 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 32 CENSORED DEATHS 19 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 243 243 427 494 504 535 539 550 568 575 |
| 584 588 596 600 610 624 630 637 639 639 |
| 644 644 647 652 662 672 674 677 679 702 |
| 706 725 |
| CENSORED DEATHS |
| 3 183 183 183 183 183 183 183 183 183 |
| 183 299 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 26 CENSORED DEATHS 18 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 253 257 283 294 331 340 351 458 497 512 |
| 539 568 582 593 597 599 616 647 662 679 |
| 682 682 703 717 722 724 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 270 456 456 456 456 456 456 456 |
| |
==================================================================================
MONOCHLOROACETIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.3 96.7 96.7 96.7 92.9 87.2 81.5 70.1 |
| | |
| | |
|15 MG/KG | 100.0 100.0 96.6 96.6 96.6 94.9 87.0 73.1 51.4 37.6 |
| | |
| | |
|30 MG/KG | 100.0 100.0 96.7 88.2 88.2 86.2 80.3 70.5 64.7 51.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 15 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.1% 37.6% 51.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.043 P=0.001 P=0.046 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 584.8 590.9 534.2 |
|NATURAL DEATHS (C) | (33.8) (19.9) (31.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 590.7 544.1 544.8 |
|(STANDARD ERROR) | (24.0) (24.2) (24.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MONOCHLOROACETIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15 MG/KG = 2
30 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 21 3
| 21 331 2 2 1
| 33 2 2 11
| 3 3 2 1 3 11 2
90 + 33 1 1
| 3 3 11
P | 333 2 2 2
E | 3 3 1 2 1
R 80 + 3 3 11
C | 2 2 11
E | 33 21 1 1
N | 33
T 70 + 3 3 222 1 1
| 33
S | 3 3 1 1
U | 3 3 2 2 11
R 60 + 33 2 22 11
V | 22 11
I | 33 22
V | 3 3 2 21 1
A 50 +
L | 3 3
| 22
| 3 3
40 + 33 2 2
| 33
| 3 3
| 3 3
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
MONOCHLOROACETIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
15 MG/KG = 2
30 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 3 3 1 2 1
| 33 2 2 11
| 3 33 22 1 1
90 + 3 3 2 2 11 1
| 3 3 2 2 1 1
P | 3 3 3 2 2 11
E | 3 3 22 1 1 1
R 80 + 3 322 11
C | 3 2 32 1 1
E | 33
N | 2 2
T 70 + 3 2 2 1 1
| 3 22 3 3
S | 22 3 3
U | 33
R 60 + 3 3
V | 22 3 3
I | 22 33
V | 2 22
A 50 + 22 3 3
L |
|
| 2 2
40 + 2 2
| 2 2
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.